This task is about reading the given passage and construct a question about the information present in the passage. Construct a question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) its answer is a continuous text span from the paragraph. Avoid creating questions that (i) can be answered correctly without actually understanding the paragraph and (ii) uses same words or phrases given in the passage.

Input: Consider Input: TB infection begins when the mycobacteria reach the pulmonary alveoli, where they invade and replicate within endosomes of alveolar macrophages. Macrophages identify the bacterium as foreign and attempt to eliminate it by phagocytosis. During this process, the bacterium is enveloped by the macrophage and stored temporarily in a membrane-bound vesicle called a phagosome. The phagosome then combines with a lysosome to create a phagolysosome. In the phagolysosome, the cell attempts to use reactive oxygen species and acid to kill the bacterium. However, M. tuberculosis has a thick, waxy mycolic acid capsule that protects it from these toxic substances. M. tuberculosis is able to reproduce inside the macrophage and will eventually kill the immune cell.

Output: What specific part of the lungs marks the start of tuberculosis infection?


Input: Consider Input: In November 2012, a referendum resulted in 54 percent of respondents voting to reject the current status under the territorial clause of the U.S. Constitution, while a second question resulted in 61 percent of voters identifying statehood as the preferred alternative to the current territorial status. The 2012 referendum was by far the most successful referendum for statehood advocates and support for statehood has risen in each successive popular referendum. However, more than one in four voters abstained from answering the question on the preferred alternative status. Statehood opponents have argued that the statehood option garnered only 45 percent of the votes if abstentions are included. If abstentions are considered, the result of the referendum is much closer to 44 percent for statehood, a number that falls under the 50 percent majority mark.

Output: What percentage of voters rejected the status of territory?


Input: Consider Input: West of Fort Washington Avenue, 181st Street is largely residential, bordering Hudson Heights and having a few shops to serve the local residents. East of Fort Washington Avenue, the street becomes increasingly commercial, becoming dominated entirely by retail stores where the street reaches Broadway and continues as such until reaching the Harlem River. It is the area's major shopping district.


Output: In which direction is 181st Street largely residential?