Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

[EX Q]: Pleiotropic effects causes symptoms associated with sickle-cell disease.
[EX A]: What causes symptoms associated with sickle-cell disease?

[EX Q]: The amniotic egg first evolved in reptiles.
[EX A]: The amniotic egg first evolved in what species?

[EX Q]: Living organisms are made up of biochemical type of carbon-based compounds.
[EX A]:
Living organisms are made up of what type of carbon-based compounds?