In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Q: Question: A 45-year-old patient who went to the emergency room for general malaise, headache and progressive tiredness in recent weeks. On physical examination, a slight icteric dye of the skin and mucous membranes was detected and a 2-cm splenomegaly was felt under the costal margin. The analytical presents hemoglobin 8.6 g / dL, VCM 100 fL. The number of reticulocytes is high and anisopoikilocytosis is observed in the blood smear. In the biochemistry highlights LDH 1300 IU / L, bilirubin 2.2 mg / dL and undetectable haptoglobin. Which test is the most appropriate to guide the diagnosis of the patient? 
 Options:  <1> Fecal occult blood test. <2> Test of Coombs. <3> Determination of iron, cobalamin and folic acid. <4> Abdominal ultrasound. <5> Bone marrow aspirate.

A: 2
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Q: Question: What element plays a physiological role in the prevention of gastroesophageal reflux? 
 Options:  <1> Upper esophageal sphincter <2> Angle of His. <3> Hernia of Hiato. <4> Purkinje angle. <5> Pyloric sphincter

A: 2
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Q: Question: Histidine and histamine are two compounds with biological importance that have in common as a structural unit: 
 Options:  <1> Pyridine <2> Piperidine <3> Triazine <4> Phenol. <5> Imidazole

A:
5
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