Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

[EX Q]: Context: Alpha-synuclein(-syn) is the main protein component of Lewy bodies (LBs), that together with nigrostriatal dopamine neuron loss constitute typical pathological hallmarks of Parkinson's disease (PD). Glutamate N-methyl-d-aspartate receptor (NMDAR) abnormalities, peculiarly involving NR2B-containing NMDAR, have been observed in the brain of PD patients and in several experimental models of the disease. Recent findings, indicating that -syn can modulate NMDAR trafficking and function, suggest that this protein may be a pivotal regulator of NMDAR activity. Prompted by these evidences, we used fluorescence immunocytochemistry, western blotting and ratiometric Ca(2+) measurements to investigate whether wild type (wt) or C-terminally truncated -syn can specifically modulate NR2B-containing NMDAR levels, subcellular trafficking and function. In addition, we evaluated whether the exposure of primary cortical neurons to increasing concentrations of rotenone could differentially regulate NR2B levels and cell viability in the presence or in the absence of -syn. Our results indicate that both wt and C-terminally truncated -syn negatively modulate NR2B-containing NMDAR levels, membrane translocation and function. Moreover, we found that absence of -syn abolishes the rotenone-dependent decrease of NR2B levels and reduces neuronal vulnerability in primary cortical neurons. These findings suggest that -syn can modulate neuronal resilience by regulating NR2B-containing NMDAR, whose specific alterations could connect -syn pathology to neuronal degeneration in PD. 
 Question: Which is the primary protein component of Lewy bodies?
[EX A]: αsyn

[EX Q]: Context: Ca2+ is a ubiquitous intracellular messenger responsible for controlling numerous cellular processes including fertilization, mitosis, neuronal transmission, contraction and relaxation of muscles, gene transcription, and cell death. At rest, the cytoplasmic Ca2+ concentration [Ca2+]i is approximately 100 nM, but this level rises to 500-1,000 nM upon activation. In osteoblasts, the elevation of [Ca2+]i is a result of an increase in the release of Ca2+ from endoplasmic reticulum and/or extracellular Ca2+ influx through voltage gated Ca2+ channels. Many of the cellular effects of Ca2+ are mediated by the Ca2+ binding protein, calmodulin (CaM). Upon binding up to four calcium ions, CaM undergoes a conformational change, which enables it to bind to specific proteins eliciting a specific response. Calmodulin kinase II (CaMKII) is a major target of the Ca(2+)/CaM second messenger system. Once bound to Ca(2+)/CaM, the multimeric CaMKII is released from its autoinhibitory status and maximally activated, which then leads to an intraholoenzyme autophosphorylation reaction. Calcineurin (Cn) is another major target protein that is activated by Ca(2+)/CaM. Cn is a serine-threonine phosphatase that consists of a heterodimeric protein complex composed of a catalytic subunit (CnA) and a regulatory subunit (CnB). Upon activation, Cn directly binds to, and dephosphorylates nuclear factor of activated T cells (NFAT) transcription factors within the cytoplasm allowing them to translocate to the nucleus and participate in the regulation of gene expression. This review will examine the potential mechanisms by which calcium, CaM, CaMKII, and Cn/NFAT control osteoblast proliferation and differentiation. 
 Question: Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)?
[EX A]: can

[EX Q]: Context: I travel a lot, and I find out different "styles" of directions every time I ask "How can I get to the post office?" Foreign tourists are often confused in Japan because most streets there don't have names; in Japan, people use landmarks in their directions instead of street names. For example, the Japanese will say to travelers,"Go straight down to the corner. Turn left at the big hotel and go past a fruit market. The post office is across from the bus stop. " In the countryside of the American Midwest, there are not usually many landmarks. There are no mountains, so the land is very flat; in many places there are no towns or buildings within miles. Instead of landmarks, people will tell you directions and distances. In Kansas or Iowa, for example, people will say," Go north two miles. Turn east, and then go another mile. " People in Los Angeles, California, have no idea of distance on the map; they measure distance in time, not miles. "How far away is the post office?" you ask. "Oh," they answer,"it's about five minutes from here. " You say," Yes, but how many miles away is it?"They don't know. It's true that a person doesn't know the answer to your question sometimes. What happens in such a situation? A New Yorker might say," Sorry, I have no idea. "But in Yucatan, Mexico, no one answers "I don't know." People in Yucatan believe that "I don't know. "is impolite. They usually give an answer, often a wrong one. A tourist can get very, very lost in Yucatan ! 
 Question: What is the place where people measure distance in time?
[EX A]:
los angeles