Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
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Question: Question: Is haploinsufficiency the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease?
Answer: The detailed characterization of this animal model provides the first in vivo evidence that Elovl4 haploinsufficiency is not the underlying key disease mechanism in STGD3. The results are consistent with a dominant negative mechanism for the deletion mutation. The Elovl4 knockout mouse is one of three complementary animal models that will help elucidate the disease mechanism.

Answer: no


Question: Question: Does milrinone attenuate serotonin-induced pulmonary hypertension and bronchoconstriction in dogs?
Answer: We studied the effects of milrinone on serotonin-induced pulmonary hypertension and bronchoconstriction in dogs. Milrinone produces pulmonary vasodilation and bronchodilation, whose effects may not be caused by beta-adrenoceptor activation. In addition, this drug may be more sensitive to phosphodiesterase III in the airway smooth muscle than that in pulmonary vascular smooth muscle.

Answer: yes


Question: Question: Does hemodynamic disturbed flow induce differential DNA methylation of endothelial Kruppel-Like Factor 4 promoter in vitro and in vivo?
Answer: Hemodynamics influence endothelial KLF4 expression through DNMT enrichment/myocyte enhancer factor-2 inhibition mechanisms of KLF4 promoter CpG methylation with regional consequences for atherosusceptibility.

Answer:
yes