TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: In this phase 2 proof-of-concept study we examined the safety and efficacy of selexipag, an orally available, selective prostacyclin receptor (IP receptor) agonist, as a treatment for pulmonary arterial hypertension (PAH). 43 adult patients with symptomatic PAH (receiving stable endothelin receptor antagonist and/or a phosphodiesterase type-5 inhibitor therapy) were randomised three to one to receive either selexipag or placebo. Dosage was up-titrated in 200-g increments from 200 g twice daily on day 1 to the maximum tolerated dose by day 35 (maximum allowed dose of 800 g twice daily). Change in pulmonary vascular resistance at week 17 expressed as a percentage of the baseline value was the primary efficacy end-point, and was analysed in the per protocol set first and then in the all-treated set to assess robustness of results. A statistically significant 30.3% reduction in geometric mean pulmonary vascular resistance was observed after 17 weeks' treatment with selexipag compared with placebo (95% confidence limits -44.7- -12.2; p=0.0045, Wilcoxon rank sum test). This was supported by a similar result from the all-treated set. Selexipag was well tolerated with a safety profile in line with the expected pharmacological effect. Our results encourage the further investigation of selexipag for the treatment of PAH.

SOLUTION: Selexipag is used for which disease?

PROBLEM: Temperature is a measure of how fast the atoms in a material are vibrating. High temperature particles vibrate faster than low temperature particles. Rapidly vibrating atoms smash together, which generates heat. As a material cools down, the atoms vibrate more slowly and collide less frequently. As a result, they emit less heat. What is the difference between heat and temperature? Temperature measures how fast a materials atoms are vibrating. Heat measures the materials total energy. Heat energy is transferred between physical entities. Heat is taken in or released when an object changes state, or changes from a gas to a liquid, or a liquid to a solid. This heat is called latent heat. When a substance changes state, latent heat is released or absorbed. A substance that is changing its state of matter does not change temperature. All of the energy that is released or absorbed goes toward changing the materials state. For example, imagine a pot of boiling water on a stove burner: that water is at 100o C (212o F). If you increase the temperature of the burner, more heat enters the water. The water remains at its boiling temperature, but the additional energy goes into changing the water from liquid to gas. With more heat the water evaporates more rapidly. When water changes from a liquid to a gas it takes in heat. Since evaporation takes in heat, this is called evaporative cooling. Evaporative cooling is an inexpensive way to cool homes in hot, dry areas. Substances also differ in their specific heat, the amount of energy needed to raise the temperature of one gram of the material by 1.0o C (1.8o F). Water has a very high specific heat, which means it takes a lot of energy to change the temperature of water. Lets compare a puddle and asphalt, for example. If you are walking barefoot on a sunny day, which would you rather walk across, the shallow puddle or an asphalt parking lot? Because of its high specific heat, the water stays cooler than the asphalt, even though it receives the same amount of solar radiation.

SOLUTION: the amount of energy needed to raise the temperature of one gram of material by 1.0oc.

PROBLEM: Puyi's last surviving younger half-brother Puren (b. 1918) has adopted the Chinese name Jin Youzhi and lived in China until his death in 2015.

SOLUTION:
What is Puyi's brothers name?