In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Example Input: Paragraph: Despite the wide use of Caenorhabditis elegans as a model organism, the first virus naturally infecting this organism was not discovered until six years ago. The Orsay virus and its related nematode viruses have a positive-sense RNA genome, encoding three proteins: CP, RdRP, and a novel δ protein that shares no homology with any other proteins. δ can be expressed either as a free δ or a CP-δ fusion protein by ribosomal frameshift, but the structure and function of both δ and CP-δ remain unknown. Using a combination of electron microscopy, X-ray crystallography, computational and biophysical analyses, here we show that the Orsay δ protein forms a~420-Å long, pentameric fiber with an N-terminal α-helical bundle, a β-stranded filament in the middle, and a C-terminal head domain. The pentameric nature of the δ fiber has been independently confirmed by both mass spectrometry and analytical ultracentrifugation. Recombinant Orsay capsid containing CP-δ shows protruding long fibers with globular heads at the distal end. Mutant viruses with disrupted CP-δ fibers were generated by organism-based reverse genetics. These viruses were found to be either non-viable or with poor infectivity according to phenotypic and qRT-PCR analyses. Furthermore, addition of purified δ proteins to worm culture greatly reduced Orsay infectivity in a sequence-specific manner. Based on the structure resemblance between the Orsay CP-δ fiber and the fibers from reovirus and adenovirus, we propose that CP-δ functions as a cell attachment protein to mediate Orsay entry into worm intestine cells. Orsay, the only virus known to naturally infect the nematode Caenorhabditis elegans, expresses a capsid-δ fusion protein. We have demonstrated that the Orsay fusion protein is incorporated into Orsay capsid and forms a~420-Å long fiber protruding from the PLOS Pathogens | 
 Title: Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells
Example Output: False

Example Input: Paragraph: The mucus-dwelling parasite Ostertagia ostertagi is one of the most important gastrointestinal nematodes in cattle. Our group has previously demonstrated the protective capacity of a vaccine against this parasite based on a native activation-associated secreted protein ASP1 (nASP) in combination with the saponin adjuvant QuilA. The aim of the current study was to analyse the effect of both antigen and adjuvant on the cellular and humoral vaccine-induced immune responses by comparing the native ASP to a recombinant version expressed in Pichia pastoris (pASP) and replacing QuilA by Al(OH) 3 . Immunization of cattle with the protective nASP+QuilA vaccine was associated with antigen-induced proliferation of natural killer (NK) cells combined with IFN-γ secretion and the induction of a mixed IgG1/IgG2 antibody response. ASP-specific activation and proliferation of NK cells was also observed in mice following the same vaccination regime. Replacing QuilA by Al(OH) 3 or nASP by pASP significantly decreased the capacity of the vaccines to trigger both NK cell activation and antibody responses and failed to induce protection against a challenge infection. Reduction of the structurally anchoring disulphide bonds of the nASP completely abolished its ability to induce NK cell activation and antibody responses, highlighting the importance of protein conformation for the immunostimulatory activity. 
 Title: Host protective ASP-based vaccine against the parasitic nematode Ostertagia ostertagi triggers NK cell activation and mixed IgG1-IgG2 response
Example Output: True

Example Input: Paragraph: Background: Estimating the prevalence of severe or critical illness and case fatality of 19 outbreak in December, 2019 remains a challenge due to biases associated with surveillance, 25 data synthesis and reporting. We aimed to address this limitation in a systematic review and 26 meta-analysis and to examine the clinical, biochemical and radiological risk factors in a meta-27 regression. 28 Methods: PRISMA guidelines were followed. PubMed, Scopus and Web of Science were 29 searched using pre-specified keywords on March 07, 2020. Peer-reviewed empirical studies 30 examining rates of severe illness, critical illness and case fatality among COVID-19 patients 31 were examined. Numerators and denominators to compute the prevalence rates and risk factors 32 were extracted. Random-effects meta-analyses were performed. Results were corrected for 33 publication bias. Meta-regression analyses examined the moderator effects of potential risk 34 factors. 35 Results: The meta-analysis included 29 studies representing 2,090 individuals. Pooled rates of 36 severe illness, critical illness and case fatality among COVID-19 patients were 15%, 5% and 37 0.8% respectively. Adjusting for potential underreporting and publication bias, increased these 38 estimates to 26%, 16% and 7.4% respectively. Increasing age and elevated LDH consistently 39 predicted severe / critical disease and case fatality. Hypertension; fever and dyspnea at 40 presentation; and elevated CRP predicted increased severity. 41 Conclusions: Risk factors that emerged in our analyses predicting severity and case fatality 42 should inform clinicians to define endophenotypes possessing a greater risk. Estimated case 43 All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity. : medRxiv preprint 3 fatality rate of 7.4% after correcting for publication bias underscores the importance of strict 44 adherence to preventive measures, case detection, surveillance and reporting. 45 46 A novel corona virus, first identified in Wuhan, China in late 2019, resulted in a 64 pandemic by the first quarter of 2020, contributed by the prolonged survival of the virus in the 65 environment and extended length of pre-or post-symptomatic and potential asymptomatic 66 shedding. 1-4 While the virus is known to cause only a mild illness in a majority, severe illness 67 characterized by respiratory distress requiring hospital admission is not uncommon. 5 68 Furthermore, the virus has the potential to precipitate a life-threatening critical illness, 69 characterized by respiratory failure, circulatory shock, sepsis or other organ failure, requiring 70 intensive care. 6, 7 
 Title: Title Case fatality rate in COVID-19: a systematic review and meta-analysis
Example Output:
True