Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Q: Context: When a new moon passes directly between the Earth and the Sun, it causes a solar eclipse (Figure 24.20). The Moon casts a shadow on the Earth and blocks our view of the Sun. This happens only all three are lined up and in the same plane. This plane is called the ecliptic. The ecliptic is the plane of Earths orbit around the Sun. The Moons shadow has two distinct parts. The umbra is the inner, cone-shaped part of the shadow. It is the part in which all of the light has been blocked. The penumbra is the outer part of Moons shadow. It is where the light is only partially blocked. When the Moons shadow completely blocks the Sun, it is a total solar eclipse (Figure 24.21). If only part of the Sun is out of view, it is a partial solar eclipse. Solar eclipses are rare events. They usually only last a few minutes. That is because the Moons shadow only covers a very small area on Earth and Earth is turning very rapidly. Solar eclipses are amazing to experience. It appears like night only strange. Birds may sing as they do at dusk. Stars become visible in the sky and it gets colder outside. Unlike at night, the Sun is out. So during a solar eclipse, its easy to see the Suns corona and solar prominences. This NASA page will inform you on when solar eclipses are expected: [Link] Sometimes a full moon moves through Earths shadow. This is a lunar eclipse (Figure 24.22). During a total lunar eclipse, the Moon travels completely in Earths umbra. During a partial lunar eclipse, only a portion of the Moon enters Earths umbra. When the Moon passes through Earths penumbra, it is a penumbral eclipse. Since Earths shadow is large, a lunar eclipse lasts for hours. Anyone with a view of the Moon can see a lunar eclipse. Partial lunar eclipses occur at least twice a year, but total lunar eclipses are less common. The Moon glows with a dull red coloring during a total lunar eclipse. The Moon does not produce any light of its own. It only reflects light from the Sun. As the Moon moves around the Earth, we see different parts of the Moon lit up by the Sun. This causes the phases of the Moon. As the Moon revolves around Earth, it changes from fully lit to completely dark and back again. A full moon occurs when the whole side facing Earth is lit. This happens when Earth is between the Moon and the Sun. About one week later, the Moon enters the quarter-moon phase. Only half of the Moons lit surface is visible from Earth, so it appears as a half circle. When the Moon moves between Earth and the Sun, the side facing Earth is completely dark. This is called the new moon phase. Sometimes you can just barely make out the outline of the new moon in the sky. This is because some sunlight reflects off the Earth and hits the Moon. Before and after the quarter-moon phases are the gibbous and crescent phases. During the crescent moon phase, the Moon is less than half lit. It is seen as only a sliver or crescent shape. During the gibbous moon phase, the Moon is more than half lit. It is not full. The Moon undergoes a complete cycle of phases about every 29.5 days. 
 Question: phase of the moon in which the entire side facing Earth is dark

A: new moon
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Q: Context: Humans did not reach space until the second half of the 20th century. They needed somehow to break past Earths gravity. A rocket moves rapidly in one direction. The device is propelled by particles flying out of it at high speed in the other direction. There are records of the Chinese using rockets in war against the Mongols as early as the 13th century. The Mongols then used rockets to attack Eastern Europe. Early rockets were also used to launch fireworks. Rockets were used for centuries before anyone could explain how they worked. The theory came about in 1687. Isaac Newton (16431727) described three basic laws of motion, now referred to as Newtons Laws of Motion: 1. An object in motion will remain in motion unless acted upon by a force. 2. Force equals mass multiplied by acceleration. 3. To every action, there is an equal and opposite reaction. Which of these three best explains how a rocket works? Newtons third law of motion. When a rockets propulsion pushes in one direction, the rocket moves in the opposite direction, as seen in the Figure 23.12. For a long time, many people believed that a rocket wouldnt work in space. There would be nothing for the rocket to push against. But they do work! Fuel is ignited in a chamber. The gases in the chamber explode. The explosion creates pressure that forces the gases out of one side of the rocket. The rocket moves in the opposite direction, as shown in Figure 23.13. The force pushing the rocket is called thrust. For centuries, rockets were powered by gunpowder or other solid fuels. These rockets could travel only short distances. Around the turn of the 20th century, several breakthroughs took place. These breakthroughs led to rockets that could travel beyond Earth. Liquid fuel gave rockets enough power to escape Earths gravity (Figure 23.14). By using multiple stages, empty fuel containers could drop away. This reduced the mass of the rocket so that it could fly higher. Rockets were used during World War II. The V2 was the first human-made object to travel high enough to be considered in space (Figure 23.15). Its altitude was 176 km (109 miles) above Earths surface. Wernher von Braun was a German rocket scientist. After he fled Germany in WWII, he helped the United States develop missile weapons. After the war, von Braun worked for NASA. He designed the Saturn V rocket (Figure One of the first uses of rockets in space was to launch satellites. A satellite is an object that orbits a larger object. An orbit is a circular or elliptical path around an object. Natural objects in orbit are called natural satellites. The Moon is a natural satellite. Human-made objects in orbit are called artificial satellites. There are more and more artificial satellites orbiting Earth all the time. They all get into space using some sort of rocket. Why do satellites stay in orbit? Why dont they crash into Earth due to the planets gravity? Newtons law of universal gravitation describes what happens. Every object in the universe is attracted to every other object. Gravity makes an apple fall to the ground. Gravity also keeps you from floating away into the sky. Gravity holds the Moon in orbit around Earth. It keeps Earth in orbit around the Sun. Newton used an example to explain how gravity makes orbiting possible. Imagine a cannonball launched from a high mountain, as shown in Figure 23.17. If the cannonball is launched at a slow speed, it will fall back to Earth. This is shown as paths (A) and (B). Something different happens if the cannonball is launched at a fast speed. The Earth below curves away at the same rate that the cannonball falls. The cannonball then goes into a circular orbit, as in path (C). If the cannonball is launched even faster, it could go into an elliptical orbit (D). It might even leave Earths gravity and go into space (E). Unfortunately, Newtons idea would not work in real life. A cannonball launched at a fast speed from Mt. Everest would not go into orbit. 
 Question: The first rocket to travel into space was used during

A: world war ii.
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Q: Context: Treatment of CLL patients with conventional cytotoxic agents is often combined with significant toxicity that prevents broad application especially in elderly patients. In addition, relapse frequently occurs after application of conventional chemotherapy in CLL. Recently several new chemo-free treatment options have been introduced within clinical trials. Among them are monoclonal antibodies, most of them targeting the CD20 molecule: besides the licensed drugs rituximab and ofatumumab obinutuzumab, although in combination with chemotherapy, has recently shown high clinical efficacy in front-line treatment of elderly patients with CLL. Lenalidomide as monotherapy has demonstrated clinical efficacy in patients with relapsed disease and first data within clinical trials have been generated in the front-line setting. A promising class of novel agents has been designed to block aberrant signaling from the B-cell receptor. Ibrutinib acts by inhibiting the Bruton's tyrosine kinase (BTK) while idelalisib represents a first-in-class specific inhibitor of the phosphoinositol-3 kinase (PI3K) delta isoform. Another class of drugs with potential impact for chemo-free treatment strategies in CLL are the BH3-mimetic inhibitors of the Bcl-2 family of pro-survival proteins. Other interesting candidate drugs that are currently explored for CLL patients include small modular immunopharmaceutical (SMIP) proteins (e. g. TRU-016), CDK inhibitors (e. g. dinaciclib), HDAC inhibitors and others. Given all these novel agents and targets, chemo-free or at least chemo-reduced concepts may become reality in the near future for our patients suffering from CLL. 
 Question: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?

A:
ibrutinib
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