Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
Empagliflozin is an orally available, potent and highly selective inhibitor of the sodium glucose cotransporter 2 (SGLT2). This study was undertaken to investigate the effect of food on the pharmacokinetics of 25 mg empagliflozin and to assess dose proportionality between 10 mg and 25 mg empagliflozin under fasted conditions. In this open-label, 3-way, cross-over study, 18 healthy volunteers received 3 single doses of empagliflozin in a randomized sequence (25 mg empagliflozin under fasted conditions, 25 mg empagliflozin after a high-fat, high-calorie breakfast and 10 mg empagliflozin under fasted conditions), each separated by a washout period of at least 7 days. Serial plasma samples were collected at selected time points over a period of 72 hours. Administration with food had no clinically relevant effect on the area under the plasma concentration-time curve (AUC0-) of empagliflozin (geometric mean ratio (GMR): 84.04, 90% confidence interval (CI): 80.86 - 87.34). The decrease observed in the maximum plasma concentrations (Cmax) of empagliflozin (GMR: 63.22, 90% CI: 56.74 - 70.44) when administered with food was not considered clinically meaningful. The increases in AUC0- and Cmax for 10 mg vs. 25 mg empagliflozin administered under fasting conditions were roughly dose-proportional, as demonstrated by the slope of the regression lines being slightly less than 1 (slope for AUC0-: 0.94, 95% CI: 0.90 - 0.97; slope for Cmax: 0.91, 95% CI: 0.80 - 1.01). Empagliflozin was well tolerated under fed and fasting conditions. The results support administration of empagliflozin tablets independently of food. Increases in empagliflozin exposure under fasting conditions were roughly dose-proportional between 10 mg and 25 mg empagliflozin.

Ex Output:
Which protein does empagliflozin inhibit?


Ex Input:
The first astronomer to record the Butterfly Cluster's existence was Giovanni Battista Hodierna in 1654.

Ex Output:
What year was Butterfly Cluster found?


Ex Input:
So that people in developed nations maintain a good lifestyle and people in developing nations have the ability to improve their lifestyles, natural resources must be conserved and protected (Figure 1.1). People are researching ways to find renewable alternatives to non-renewable resources. Here is a checklist of ways to conserve resources: Buy less stuff (use items as long as you can, and ask yourself if you really need something new). Reduce excess packaging (drink tap water instead of water from plastic bottles). Recycle materials such as metal cans, old cell phones, and plastic bottles. Purchase products made from recycled materials. Reduce pollution so that resources are maintained. Prevent soil erosion. Plant new trees to replace those that are cut down. Drive cars less, take public transportation, bicycle, or walk. Conserve energy at home (turn out lights when they are not needed). Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:

Ex Output:

which one of these can you not recycle