TASK DEFINITION: Convert a disfluent question to a proper question. A disfluent question is a question that has some interruptions in it while framing. A proper question is the correct form of the question without any disfluency.
PROBLEM: Where or no make that what happens when the immune system loses tolerance for tumor antigens?

SOLUTION: What happens when the immune system loses tolerance for tumor antigens?

PROBLEM: How no who does not define what constitutes a patient-doctor relationship?

SOLUTION: Who does not define what constitutes a patient-doctor relationship?

PROBLEM: What has it now become possible let me rephrase what is now possible regarding dating isotopes while using fossils?

SOLUTION:
What has it now become possible to do when dating isotopes while using fossils?