instruction:
This task is about creating an unanswerable question based on a given passage. Construct a question that looks relevant to the given context but is unanswerable. Following are a few suggestions about how to create unanswerable questions:
(i) create questions which require satisfying a constraint that is not mentioned in the passage
(ii) create questions which require information beyond what is provided in the passage in order to answer
(iii) replace an existing entity, number, date mentioned in the passage with other entity, number, date and use it in the question
(iv) create a question which is answerable from the passage and then replace one or two words by their antonyms or insert/remove negation words to make it unanswerable.
question:
Passage: Downtown San Diego is the central business district of San Diego, though the city is filled with business districts. These include Carmel Valley, Del Mar Heights, Mission Valley, Rancho Bernardo, Sorrento Mesa, and University City. Most of these districts are located in Northern San Diego and some within North County regions.
answer:
What is the central business district of downtown San Diego?


question:
Passage: The war had removed Bermuda's primary trading partners, the American colonies, from the empire, and dealt a harsh blow to Bermuda's merchant shipping trade. This also suffered due to the deforestation of Bermuda, as well as the advent of metal ships and steam propulsion, for which it did not have raw materials. During the course of the following War of 1812, the primary market for Bermuda's salt disappeared as the Americans developed their own sources. Control of the Turks had passed to the Bahamas in 1819.
answer:
What was the primary market for Bermuda following the War of 1812?


question:
Passage:  Among the vast varieties of microorganisms, relatively few cause disease in otherwise healthy individuals. Infectious disease results from the interplay between those few pathogens and the defenses of the hosts they infect. The appearance and severity of disease resulting from any pathogen, depends upon the ability of that pathogen to damage the host as well as the ability of the host to resist the pathogen. However a host's immune system can also cause damage to the host itself in an attempt to control the infection. Clinicians therefore classify infectious microorganisms or microbes according to the status of host defenses - either as primary pathogens or as opportunistic pathogens:
answer:

How many microorganisms cause repair in otherwise healthy individuals?