In this task, you are given the abstract of a research paper. Your task is to generate a summary of this abstract. Your summary should not be very short, but it's better if it's not more than 30 words.

Input: Consider Input: Profiling cellular phenotypes from microscopic imaging can provide meaningful biological information resulting from various factors affecting the cells. One motivating application is drug development: morphological cell features can be captured from images, from which similarities between different drugs applied at different dosages can be quantified. The general approach is to find a function mapping the images to an embedding space of manageable dimensionality whose geometry captures relevant features of the input images. An important known issue for such methods is separating relevant biological signal from nuisance variation. For example, the embedding vectors tend to be more correlated for cells that were cultured and imaged during the same week than for cells from a different week, despite having identical drug compounds applied in both cases. In this case, the particular batch a set of experiments were conducted in constitutes the domain of the data; an ideal set of image embeddings should contain only the relevant biological information (e.g. drug effects). We develop a general framework for adjusting the image embeddings in order to `forget' domain-specific information while preserving relevant biological information. To do this, we minimize a loss function based on distances between marginal distributions (such as the Wasserstein distance) of embeddings across domains for each replicated treatment. For the dataset presented, the replicated treatment is the negative control. We find that for our transformed embeddings (1) the underlying geometric structure is not only preserved but the embeddings also carry improved biological signal (2) less domain-specific information is present.

Output: We correct nuisance variation for image embeddings across different domains, preserving only relevant information.


Input: Consider Input: We revisit the Recurrent Attention Model (RAM, Mnih et al. (2014)), a recurrent neural network for visual attention, from an active information sampling perspective. 

 We borrow ideas from neuroscience research on the role of active information sampling in the context of visual attention and gaze (Gottlieb, 2018), where the author suggested three types of motives for active information sampling strategies. We find the original RAM model only implements one of them.

 We identify three key weakness of the original RAM and provide a simple solution by adding two extra terms on the objective function. The modified RAM 1) achieves faster convergence, 2) allows dynamic decision making per sample without loss of accuracy, and 3) generalizes much better on longer sequence of glimpses which is not trained for, compared with the original RAM. 


Output:  Inspired by neuroscience research, solve three key weakness of the widely-cited recurrent attention model by simply adding two terms on the objective function.


Input: Consider Input: Inspired by the combination of feedforward and iterative computations in the visual cortex, and taking advantage of the ability of denoising autoencoders to estimate the score of a joint distribution, we propose a novel approach to iterative inference for capturing and exploiting the complex joint distribution of output variables conditioned on some input variables. This approach is applied to image pixel-wise segmentation, with the estimated conditional score used to perform gradient ascent towards a mode of the estimated conditional distribution. This extends previous work on score estimation by denoising autoencoders to the case of a conditional distribution, with a novel use of a corrupted feedforward predictor replacing Gaussian corruption. An advantage of this approach over more classical ways to perform iterative inference for structured outputs, like conditional random fields (CRFs), is that it is not any more necessary to define an explicit energy function linking the output variables. To keep computations tractable, such energy function parametrizations are typically fairly constrained, involving only a few neighbors of each of the output variables in each clique. We experimentally find that the proposed iterative inference from conditional score estimation by conditional denoising autoencoders performs better than comparable models based on CRFs or those not using any explicit modeling of the conditional joint distribution of outputs.


Output: Refining segmentation proposals by performing iterative inference with conditional denoising autoencoders.