TASK DEFINITION: Given a document, generate a short title of the document. The title should convey the main idea/event/topic about which the document is being written. Note that URLs in the text have been replaced with [Link].
PROBLEM: A few years ago he began working with Dr. Jenny Chang  medical director of the Lester and Sue Smith Breast Center at Baylor College of Medicine.
 Chang had performed a number of biopsies on breast cancer patients  both on those whose cancers were confined to the breast and on those whose cancers had metastasized to the brain.
 From those biopsies  Chang said she had identified a number of genetic pathways ways in which gene mutations affected the ability of the cancer to spread unique to patients who developed metastatic breast cancer.
 "But I had a lot of trouble with the data and trying to translate it into clinical practice " she said. She couldn't find her way out from beneath the avalanche of data.
 So she turned to Wong.
 Using his mathematical modeling  Wong sifted through Chang's data and the large databases of genome and clinical trial data. Out of that  he identified several candidate drugs to impair the genetic pathways that helped the cancer spread.
Chang's data and the large databases of genome and clinical trial data. Out of that  he identified several candidate drugs to impair the genetic pathways that helped the cancer spread.
 One of them  a drug named sunitinib  which treats a kidney cancer called renal cell carcinoma  emerged as the best bet. Chang then tested the drug in mice  and the study showed it prevented breast cancer from spreading to the brain.
 She has already begun a Phase II clinical trial of the drug  enrolling nine patients with metastatic breast cancer  and she is looking for more.
 "The drug is very well-tolerated by patients  and so far the trial is going very well " Chang said.
 But by using an existing drug  Chang and Wong could skip the lengthy Phase I  during which a drug is checked for safety. If Chang's tests go well  sunitinib could be on the market within a few years for metastatic breast cancer.

SOLUTION: IN OLD DRUGS RESEARCHER LOOKS FOR NEW TREATMENTS

PROBLEM: Actor John Bradley  who plays Sam  Tarly  told TV Guide that characters are going to keep being pushed by new elements and traveling the seven kingdoms deeper and faster than ever before.
"Each of the characters this year is placed in a completely alien environment at some point in the season that they've never been placed in before "  Bradley  said. "The thrill is seeing how they react to it and how they respond... This season  I think  more than any other is stretching these characters."
But  Bradley 's comments are intriguing from a character perspective. An alien environment isn't necessarily a physical place; it's an unfamiliar situation (Arya  no longer sniffing out traitors)  an important task (Cersei trying to play nice with others)  or a new threat (White! Walkers!).
"The stakes definitely feel ramped up  " Bradley  told TV Guide. "We know that we've got a real job to do. This has been a part of people's lives for so many years. This is our eighth season  and we are kind of feeling the pressure to get it right because we want to satisfy people...we just kind of want to give them an ending that they deserve."

SOLUTION: 'Game of Thrones' characters will keep traveling in Season 8

PROBLEM: Choi Soon-sil  a longtime friend of former President Park Geun-hye  was convicted Tuesday for abusing her close ties with Park to gain personal profit and for receiving bribes from Samsung  Lotte and other big South Korean businesses.
The court also sentenced Choi Soon-sil  the former President Park Geun-hye's confidante to 20 years in prison.
Lotte was one of many major companies that donated money to non-profit foundations controlled by  Choi .
The Seoul Central District Court said Tuesday that Choi Soon-sil was convicted on abuse of power  bribery and other charges. The court also imposed 18 billion won ($17 million) fine on her.
The court said  Choi  abused  her  close tie with the former president to take personal profit. Among  her  crime was coercing businesses to donate a huge amount of money to foundations under  her  control and receiving bribes from Samsung and Lotte.
It said  her  crime was grave given how  she  triggered an unprecedented impeachment of the president and disappointed the public.
 Choi Soon-sil  emerged Tuesday from a police bus with flashing lights and entered the court in Seoul. She has been jailed during her trial.
 Choi  is charged with abuse of power and eight other charges stemming from her role in nonprofit foundations and a winter sports center that solicited funds from top South Korean companies.
The Seoul Central District Court says it will issue a verdict Tuesday afternoon. Choi Soon-sil  a confidante of former President Park Geun-hye  was tried on abuse of power and eight other charges.

SOLUTION:
The Latest: Confidante of ex