instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
In this phase 2 proof-of-concept study we examined the safety and efficacy of selexipag, an orally available, selective prostacyclin receptor (IP receptor) agonist, as a treatment for pulmonary arterial hypertension (PAH). 43 adult patients with symptomatic PAH (receiving stable endothelin receptor antagonist and/or a phosphodiesterase type-5 inhibitor therapy) were randomised three to one to receive either selexipag or placebo. Dosage was up-titrated in 200-g increments from 200 g twice daily on day 1 to the maximum tolerated dose by day 35 (maximum allowed dose of 800 g twice daily). Change in pulmonary vascular resistance at week 17 expressed as a percentage of the baseline value was the primary efficacy end-point, and was analysed in the per protocol set first and then in the all-treated set to assess robustness of results. A statistically significant 30.3% reduction in geometric mean pulmonary vascular resistance was observed after 17 weeks' treatment with selexipag compared with placebo (95% confidence limits -44.7- -12.2; p=0.0045, Wilcoxon rank sum test). This was supported by a similar result from the all-treated set. Selexipag was well tolerated with a safety profile in line with the expected pharmacological effect. Our results encourage the further investigation of selexipag for the treatment of PAH.
answer:
Selexipag is used for which disease?


question:
HD 114837 is a star in the constellation Centaurus.
answer:
The star HD 114837 is part of the constellation known as what?


question:
The Battle of Milne Bay (25 August -- 7 September 1942), also known as Operation RE by the Japanese, was a battle of the Pacific campaign of World War II. Elite Japanese naval troops, known as Kaigun Rikusentai (Special Naval Landing Forces), with tank support attacked the Allied airfields at Milne Bay that had been established on the eastern tip of New Guinea.
answer:

On what date did Battle of Milne Bay end?