Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

The translocation (9;22) gives rise to the p190(Bcr-Abl) and p210(Bcr-Abl) tyrosine kinase proteins, considered sufficient for leukemic transformation. Philadelphia-positive (Ph(+)) acute leukemia patients failing to respond to initial induction therapy have a poor prognosis with few effective treatment options. Imatinib is an orally administered, potent inhibitor of the Bcr-Abl tyrosine kinase. We conducted a clinical trial in 56 patients with relapsed or refractory Ph(+) acute lymphoblastic leukemia (ALL; 48 patients) or chronic myelogenous leukemia in lymphoid blast crisis (LyBC; 8 patients). Imatinib was given once daily at 400 mg or 600 mg. Imatinib induced complete hematologic responses (CHRs) and complete marrow responses (marrow-CRs) in 29% of ALL patients (CHR, 19%; marrow-CR, 10%), which were sustained for at least 4 weeks in 6% of patients. Median estimated time to progression and overall survival for ALL patients were 2.2 and 4.9 months, respectively. CHRs were reported for 3 (38%) of the patients with LyBC (one sustained CHR). Grade 3 or 4 treatment-related nonhematologic toxicity was reported for 9% of patients; none of the patients discontinued therapy because of nonhematologic adverse reactions. Grade 4 neutropenia and thrombocytopenia occurred in 54% and 27% of patients, respectively. Imatinib therapy resulted in a clinically relevant hematologic response rate in relapsed or refractory Ph(+) acute lymphoid leukemia patients, but development of resistance and subsequent disease progression were rapid. Further studies are warranted to test the effects of imatinib in combination with other agents and to define the mechanisms of resistance to imatinib.
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

Transcription factors of the NFAT (nuclear factor of activated T cells) family are expressed in most immune system cells and in a range of other cell types. Signaling through NFAT is implicated in the regulation of transcription for the immune response and other processes, including differentiation and apoptosis. NFAT normally resides in the cytoplasm, and a key aspect of the NFAT activation pathway is the regulation of its nuclear import by the Ca(2+)/calmodulin-dependent phosphatase calcineurin. In a cell line stably expressing green fluorescent protein (GFP)-NFAT, this import can be triggered by elevation of intracellular calcium and visualized in live cells. Here we show that the inducible nuclear import of GFP-NFAT is efficiently blocked at early stages of herpes simplex virus (HSV) infection. This is a specific effect, since we observed abundant nuclear accumulation of a test viral protein and no impediment to general nuclear localization signal-dependent nuclear import and retention in infected cells. We show that virus binding at the cell surface is not itself sufficient to inhibit the signaling that induces NFAT nuclear translocation. Since the block occurs following infection in the presence of phosphonoacetic acid but not cycloheximide, we infer that the entry of the virion and early gene transcription are required but the effect is independent of DNA replication or late virus gene expression. A consequence of the block to GFP-NFAT import is a reduction in NFAT-dependent transcriptional activation from the interleukin-2 promoter in infected cells. This HSV-mediated repression of the NFAT pathway may constitute an immune evasion strategy or subversion of other NFAT-dependent cellular processes to promote viral replication.
Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)?

The ability to see is called vision. It depends on both the eyes and the brain. The eyes sense light and form images. The brain interprets the images formed by the eyes and tells us what we are seeing. For a fascinating account of how the brain helps us see, watch this short video: . MEDIA Click image to the left or use the URL below. URL: Did you ever use 3-D glasses to watch a movie, like the teens in Figure 20.11? If you did, then you know that the glasses make images on the flat screen seem more realistic by giving them depth. The images seem to jump right out of the screen toward you. Unlike many other animals, human beings and other primates normally see the world around them in three dimen- sions. Thats because we have two eyes that face the same direction but are a few inches apart. Both eyes focus on the same object at the same time but from slightly different angles. The brain uses the different images from the two eyes to determine the distance to the object. Human beings and other primates also have the ability to see in color. We have special cells inside our eyes that can distinguish different wavelengths of visible light. Visible light is light in the range of wavelengths that the human eye can sense. The exact wavelength of visible light determines its color. The function of the eye is to focus light and form images. We see some objects, such as stars and light bulbs, because they give off their own light. However, we see most objects because they reflect light from another source such as the sun. We form images of the objects when some of the reflected light enters our eyes. Look at the parts of the eye in Figure 20.12. Follow the path of light through the eye as you read about it below. 1. Light from an object passes first through the cornea. This is a clear, protective covering on the outside of the eye. 2. Then light passes through the pupil, an opening in the center of the eye. The pupil, which looks black, is surrounded by the colored part of the eye, called the iris. 3. Light entering through the pupil next passes through the lens. The lens is a clear, curved structure, like the lens of a magnifying glass. Along with the cornea, the lens focuses the light on the back of the eye. 4. The back of the eye is covered by a thin layer called the retina. This is where the image of the object normally forms. The retina consists of special light-sensing cells called rods and cones. Rods sense dim light. Cones sense different colors of light. 5. Nerve impulses from rods and cones travel to the optic nerve. It carries the nerve impulses to the brain. You probably know people who need eyeglasses or contact lenses to see clearly. Maybe you need them yourself. Lenses are used to correct vision problems. Two of the most common vision problems in young people are myopia and hyperopia. You can compare myopia and hyperopia in Figure 20.13. To learn about astigmatism, another common vision problem, watch this very short video: . MEDIA Click image to the left or use the URL below. URL: Myopia is commonly called nearsightedness. People with myopia can see nearby objects clearly, but distant objects appear blurry. Myopia occurs when images focus in front of the retina because the eyeball is too long. This vision problem can be corrected with concave lenses, which curve inward. The lenses focus images correctly on the retina. Hyperopia is commonly called farsightedness. People with hyperopia can see distant objects clearly, but nearby objects appear blurry. Hyperopia occurs when images focus in back of the retina because the eyeball is too short. This vision problem can be corrected with convex lenses, which curve outward. The lenses focus images correctly on the retina. Vision is just one of several human senses. Other human senses include hearing, touch, taste, and smell. Imagine shopping at the fruit market in Figure 20.14. It would stimulate all of these senses. You would hear the

__vision problem in which nearby objects can be seen clearly but distant objects appear blurry