In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Q: Paragraph: Host-pathogen interactions provide a fascinating example of two or more active genomes directly exerting mutual influence upon each other. These encounters can lead to multiple outcomes from symbiotic homeostasis to mutual annihilation, undergo multiple cycles of latency and lysogeny, and lead to coevolution of the interacting genomes. Such systems pose numerous challenges but also some advantages to modeling, especially in terms of functional, mathematical genome representations. The main challenges for the modeling process start with the conceptual definition of a genome for instance in the case of hostintegrated viral genomes. Furthermore, hardly understood influences of the activity of either genome on the other(s) via direct and indirect mechanisms amplify the needs for a coherent description of genome activity. Finally, genetic and local environmental heterogeneities in both the host's cellular and the pathogen populations need to be considered in multiscale modeling efforts. We will review here two prominent examples of host-pathogen interactions at the genome level, discuss the current modeling efforts and their shortcomings, and explore novel ideas of representing active genomes which promise being particularly adapted to dealing with the modeling challenges posed by host-pathogen interactions. 
 Title: Critical Dynamics in Host-Pathogen Systems

A: True
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Q: Paragraph: The Mediterranean diet is rich in fruits and vegetables, monounsaturated fatty acids from olive oil, and is complemented with the traditional use of culinary and medicinal herbs and spices. An important feature of this diet is the negative association with the incidence of metabolic syndrome, which is characterized by increased risk of cardiovascular disease. Conformity to the Mediterranean diet has also been linked to a decreased risk of cardiovascular disease and cancer in US populations. Plants that originated in the Mediterranean basin have been used for centuries in botanical therapies. Many of these plants are believed to prevent and/or cure a wide spectrum of ailments based on their content in bioactive components that exert anti-oxidant, anti-infl ammatory, anticarcinogenic, anti-diabetic, and anti-thrombotic functions. This chapter underlines the health benefi ts that may derive from utilization through dietary assumption or medicinal applications of a selected group of plant products including extracts and specifi c bioactive components found in rosemary, licorice, chamomile, and olive oil. Each section provides a scientifi c analysis of the most recent literature and attempts to highlight the mechanisms of action and molecular targets of bioactive components derived from these plants. 
 Title: Health Benefi ts of Traditional Culinary and Medicinal Mediterranean Plants

A: False
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Q: Paragraph: is not known whether they edit RNA genomes through cytidine deamination. Here, we investigated APOBEC3-mediated restriction of Coronaviridae. In experiments in vitro, three human APOBEC3 proteins (A3C, A3F and A3H) inhibited HCoV-NL63 infection and limited production of progeny virus, but did not cause hypermutation of the coronaviral genome. APOBEC3-mediated restriction was partially dependent on enzyme activity, and was reduced by the use of enzymatically inactive APOBEC3. Moreover, APOBEC3 proteins bound to the coronaviral nucleoprotein, and this interaction also affected viral replication. Although the precise molecular mechanism of deaminasedependent inhibition of coronavirus replication remains elusive, our results further our understanding of APOBEC-mediated restriction of RNA virus infections. Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like type 3 (APOBEC3) proteins are Zn 2+dependent cytidine deaminases that belong to the APOBEC superfamily. APOBEC3 enzymes are considered to be part of the intrinsic defense system in eukaryotic cells, and can inhibit replication of some viruses and restrict mobile genetic elements. All APOBEC3 proteins share a cytidine-deaminase domain, which is identifiable by the primary amino acid motif His-Xaa-Glu-Xaa 23-28 -Pro-Cys-Xaa 2-4 -Cys, in which Zn 2+ is coordinated. Deamination of cytidine results in its conversion to uridine. During this process, the ammonium group on C 4 of cytidine undergoes nucleophilic attack by an activated water molecule and the APOBEC3 glutamate residue. A single copy of a gene encoding APOBEC3 is found in the genomes of rodents, cats, pigs and sheeps, with two genes in the genomes of cows, three the genomes of dogs and horses and seven genes in the human genome, encoding A3A, A3B, A3C, A3D, A3F, A3G and A3H 1 . The mechanisms and selective pressures that led to the APOBEC3 gene expansion in humans are unclear, but it is believed that all the genes originated from duplication of a single-copy primordial APOBEC3 gene. This multiplication may have provided protection from genomic instability caused by human endogenous retroviruses and retrotransposons 2 . The best-studied protein within the human APOBEC3 family is A3G. Its function as an antiviral factor was discovered in 2002 through cDNA-transfer experiments that were designed to identify a cellular suppressor of an HIV-1 accessory protein, the virion infectivity factor (Vif). The primary antiretroviral activity of A3G requires its encapsidation into HIV-1 particles, and involves cytidine deamination of the reverse-transcribed first viral DNA strand, with mutations becoming fixed as G to A changes upon second-strand synthesis. Mutational frequencies can exceed 10% of all G residues (hypermutation), and may result in inhibition of viral replication. This activity is blocked by Vif protein, which specifically binds to and ubiquitinates A3G, directing it for degradation in the Published: xx xx xxxx OPEN www.nature.com/scientificreports/ 2 ScIentIFIc REPORts | (2018) 8:5960 | 
 Title: APOBEC3-mediated restriction of RNA virus replication OPEN

A:
False
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