In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Example Input: Question: The reovirus .: 
 Options:  <1> They are released from the cell by budding. <2> They replicate their genetic material in the cell nucleus. <3> They have a lipid envelope. <4> They form virions resistant to acid pH. <5> They are transmitted by blood.
Example Output: 4

Example Input: Question: A 5-year-old boy with symptoms of possible meningitis is seen in an emergency department. Gram-negative diplococci and abundant polymorphonuclear leukocytes are observed in the Gram stain of the cerebrospinal fluid sediment. What microorganism does it suggest as a possible cause of the infection ?: 
 Options:  <1> Haemophilus influenzae. <2> Streptococcus pneumoniae <3> Streptococcus agalactiae. <4> Neisseria meningitidis. <5> Listeria monocytogenes.
Example Output: 4

Example Input: Question: The simultaneous expression of IgM and IgD as membrane immunoglobulins occurs in: 
 Options:  <1> B cells that respond to thymoindependent antigens. <2> B cells that respond to thymus-dependent antigens. <3> Activated B cells stimulated by Interleukin 4 (IL-4). <4> Immature virgin B cells. <5> Mature virgin B cells.
Example Output:
5