In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Example Input: A series of 4-aminoquinoline derivatives were synthesized by the reaction of 4-chloro-7-substituted-quinolines with the corresponding mono/ dialkyl amines. The structures of the synthesized compounds were confirmed by NMR and FAB-MS spectral and elemental analyses. Subsequently, the compounds were examined for their cytotoxic effects on two different human breast tumor cell lines: MCF7 and MDA-MB468. Although all compounds examined were quite effective on both cell lines, the compound N 0 -(7-chloro-quinolin-4-yl)-N,N-dimethyl-ethane-1,2-diamine emerged as the most active compound of the series. It was particularly potent against MDA-MB 468 cells when compared to chloroquine and amodiaquine. The compound butyl-(7-fluoro-quinolin-4-yl)-amine showed more potent effects on MCF-7 cells when compared to chloroquine. Therefore, 4-aminoquinoline can serve as the prototype molecule for further development of a new class of anticancer agents.
Example Output: Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives

Example Input: The primary objective of this randomized controlled trial was to determine whether anti-IL-10 egg yolk antibodies fed upon arrival to a calf ranch would lower the prevalence of Cryptosporidium parvum shedding in naturally challenged preweaned dairy calves. The secondary objectives included measuring the effect of anti-IL-10 antibodies on calf health, performance, and shedding of less common diarrheal pathogens. A total of 133 calves, enrolled at 24 to 72 h of age, received a daily dose of 0.96 g of egg yolk powder with anti-IL-10 antibodies (MAB, n = 71) or without anti-IL-10 antibodies (MEP, n = 62) split between 2 feedings for the first 11 d on feed at a calf ranch. Daily health evaluations were completed for 15 d after arrival and on d 56. Digital weights were collected at enrollment and d 56, and hipometer weights were collected at enrollment and d 7 and 56. Packed cell volume and serum total protein concentration were measured at enrollment and on d 7 and 14. Fecal pH was measured at enrollment and on d 5 and 14, and fecal pathogen (C. parvum, coronavirus, rotavirus, and Salmonella spp.) shedding was assessed at d 5 and 14. Continuous outcomes were compared between groups using a Student's t-test or Wilcoxon rank sum test. Fecal pathogen shedding at d 14, respiratory disease at d 56, and antibiotic usage were compared using relative risk (RR) and chi-squared test. Fecal pH (median and interquartile range) on d 14 was 6.65 (6.39-6.99) and 6.52 (5.97-6.81) for MAB and MEP, respectively. On d 56, the risk of respiratory disease was lower for MAB compared with MEP (RR = 0.40; confidence interval = 0.16-0.99). The risk for antibiotic treatment was lower for MAB-compared with MEP-treated calves (RR = 0.38; confidence interval = 0.17-0.88). The risk of shedding rotavirus was higher in MAB (RR = 1.38; confidence interval = 1.10-1.81) calves. After multivariable analyses, hipometer weights (least squares means ± standard error) were 1.7 ± 0.8 kg greater on d 56 in MAB compared with MEP; however, ADG was 0.04 ± 0.02 kg/d lower in MAB calves. Total health score, diarrhea days, average respiratory score, packed cell volume, and serum total protein were not affected by feeding anti-IL-10 egg antibodies. In summary, feeding anti-IL-10 antibodies was associated with increased fecal pH, reduced risk of respiratory disease later in the preweaning period, and decreased antibiotic usage despite higher rotavirus infection. These findings might be associated with improved mucosal immunity, enhanced host defenses, or reduced susceptibility and warrant further investigation.
Example Output: Health benefits of orally administered anti-IL-10 antibody in milk-fed dairy calves

Example Input: To analyze pathogenic species in bats from southeast coastal regions of China, we performed metagenomic sequencing technology for high throughput sequencing of six sentinels from southeast coastal area of China. We obtained 5,990,261 high quality reads from intestine and lung tissue of 235 bats, including 2,975,371 assembled sequences. 631,490 reads predicted overlapping sequences for the open reading frame (ORF), which accounts for 2.37% of all the sequences (15,012/631,490). Further, the acquired virus sequences were classified into 25 viral families, including 16 vertebrate viruses, four plant viruses and five insect viruses. All bat samples were screened by specific PCR and phylogenetic analysis. Using these techniques, we discovered many novel bat viruses and some bat viruses closelyrelated to known human/animal pathogens, including coronavirus, norovirus, adenovirus, bocavirus, astrovirus, and circovirus. In summary, this study extended our understanding of bats as the viral reservoirs. Additionally, it also provides a basis for furher studying the transmission of viruses from bats to humans. Bats belong to the order Chiroptera, and are the second largest order of mammals after rodents. This order includes 19 families and 962 species distributed across the globe 1 . More than 130 kinds of viruses have been detected in bats, including more than 60 species of zoonotic viruses which are highly pathogenic in humans 2 , such as severe acute respiratory syndrome (SARS)-like coronavirus (SL-CoV), Ebola virus, Nipah virus, and Hendra virus 3-6 . In 2002, SARS outbreak in China infected more than 8,000 people worldwide and killed at least 800 people. Chinese horseshoe bats were proved to be the natural reservoirs of SARS-CoV and that intermediate hosts may not be necessary for direct human infection by a bat hosting SL-CoV 7 . Similarly, Middle East respiratory syndrome (MERS)-associated coronavirus were detected in bats, and required dipeptidyl peptidase 4 cell receptors for its invasion into host cells 8 . It seems likely that bats might act as natural hosts which critical roles in viral iner-host transmission. In the last five years, the use of second-generation sequence technology allowed us to elucidate a flood of viruses, like SARS-CoV, hepatitis B virus, rotavirus and other important viruses 9-11 . In 2010, meta-genomic analysis was conducted for the first time, following the second generation sequencing of oral swab and faecal samples from 41 bats of three common North American bat species. The results showed that sample pools contained strong matches to at least three novel group of CoVs, and large numbers of insect and plant virus sequences were identified 12 . One bat virome analysis conducted by Ge et al. on fecal samples of bats from six locations in China 13 , and 97 contigs were found to be related to eukaryotic viruses, including coronavirus. Then, one bat virome analysis in Myanmar conducted by He et al. has identified many new mammalian viruses of Myanmar bats 14 , showing
Example Output:
Virome analysis for identification of novel mammalian viruses in bats from Southeast China OPEN