This task is about reading the given passage and construct a question about the information present in the passage. Construct a question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) its answer is a continuous text span from the paragraph. Avoid creating questions that (i) can be answered correctly without actually understanding the paragraph and (ii) uses same words or phrases given in the passage.
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Question: TB infection begins when the mycobacteria reach the pulmonary alveoli, where they invade and replicate within endosomes of alveolar macrophages. Macrophages identify the bacterium as foreign and attempt to eliminate it by phagocytosis. During this process, the bacterium is enveloped by the macrophage and stored temporarily in a membrane-bound vesicle called a phagosome. The phagosome then combines with a lysosome to create a phagolysosome. In the phagolysosome, the cell attempts to use reactive oxygen species and acid to kill the bacterium. However, M. tuberculosis has a thick, waxy mycolic acid capsule that protects it from these toxic substances. M. tuberculosis is able to reproduce inside the macrophage and will eventually kill the immune cell.

Answer: What specific part of the lungs marks the start of tuberculosis infection?


Question: During the Cantonal Revolution of 1873, a cantonalist uprising that took place during the First Spanish Republic, the city was consolidated with most of the nearby cities in the Federal Canton of Valencia (proclaimed on 19 July and dissolved on 7 August). It did not have the revolutionary fervor of the movement in cities like Alcoy, as it was initiated by the bourgeoisie, but the Madrid government sent General Martinez-Campos to stifle the rebellion by force of arms and subjected Valencia to an intense bombardment. The city surrendered on 7 August; Alfonso XII was proclaimed king on 29 December 1874, and arrived in Valencia on 11 January 1875 on his way to Madrid, marking the end of the first republic. Despite the Bourbon restoration, the roughly even balance between conservatives and liberals in the government was sustained in Valencia until the granting of universal male suffrage in 1890, after which the Republicans, led by Vicente Blasco Ibáñez, gained considerably more of the popular vote.

Answer: In what year did the cantonalist uprising occur?


Question: The World Health Organization declared TB a "global health emergency" in 1993, and in 2006, the Stop TB Partnership developed a Global Plan to Stop Tuberculosis that aims to save 14 million lives between its launch and 2015. A number of targets they have set are not likely to be achieved by 2015, mostly due to the increase in HIV-associated tuberculosis and the emergence of multiple drug-resistant tuberculosis. A tuberculosis classification system developed by the American Thoracic Society is used primarily in public health programs.

Answer:
What group heads up the Global Plan to Stop Tuberculosis?