instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
It was 1:30 a.m. Monday at London's Savoy Hotel and, with autograph books and cameras, a group of brighteyed tennis fans of all ages were waiting for just a glimpse of Maria Sharapova . The 17-year-old girl defeated champion Serena Williams 6-1 6-4 in the Wimbledon final on Saturday in London to become the first Russian to win a single title at the championships. A silver lining to a depressing, rain-hit Wimbledon, she has raised heated passion. Nobody was complaining, though, for the 1.83-metre Sharapova has created a welcome wave of interest in tennis, something missing in recent years. Not even Anna Kournikova evoked such passion when she broke on to the scene. To look good on court is one thing, but Sharapova can actually play the game too. Extremely well. She proved it over 13 days at the world's most prestigious tournament. Playing tennis of the highest quality throughout, the Russian's triumph not only lifted the tournament from fits of rain-induced depression but also salvaged(;) the season for the woman's tour. Sharapova was given no easy ride in the tournament, having to beat 1999 champion Lindsay Davenport in the semifinals and twice-champion Serena Williams for the title. Neither caused her much concern. "I don't remember too much about the final," Sharapova giggled. "I was in my own place." She will find it increasingly hard to find any place to call her own from now on after advertisers identified her as the most marketable woman in sport. In Russia she is sensational news. She headlined the news bulletins and was telephoned by former Russian President Boris Yeltsin after her triumph. Sharapova will return to her adoptive Florida home knowing life will never be the same again. But the girl who arrived in the US aged seven with her father and just US$700 is determined not to let fame and riches detract from her number one love, tennis. "I know things will start coming up and that many more things will want to get involved, but I want to keep my head cool and play tennis," she said.
answer:
Who has won the most times in Wimbledon?


question:
Restless legs syndrome is a neurological disorder characterized by an urgency to move the legs during periods of rest. Data from a variety of sources provide a compelling argument that the amount of iron in the brain is lower in individuals with restless legs syndrome compared with neurologically normal individuals. Moreover, a significant percentage of patients with restless legs syndrome are responsive to intravenous iron therapy. The mechanism underlying the decreased iron concentrations in restless legs syndrome brains is unknown. We hypothesize that the source of the brain iron deficit is at the blood-brain interface. Thus we analysed the expression of iron management proteins in the epithelial cells of the choroid plexus and the brain microvasculature in post-mortem tissues. The choroid plexus, obtained at autopsy, from 18 neurologically normal controls and 14 individuals who had primary restless legs syndrome was subjected to histochemical staining for iron and immunostaining for iron management proteins. Iron and heavy chain ferritin staining was reduced in the epithelial cells of choroid plexus in restless legs syndrome. Divalent metal transporter, ferroportin, transferrin and its receptor were upregulated in the choroid plexus in restless legs syndrome. Microvessels were isolated from the motor cortex of 11 restless legs syndrome and 14 control brains obtained at autopsy and quantitative immunoblot analyses was performed. Expression of heavy chain ferritin, transferrin and its receptor in the microvessels from restless legs syndrome was significantly decreased compared with the controls but divalent metal protein 1, ferroportin, prohepcidin, mitochondrial ferritin and light-chain ferritin remained unchanged. The presence of an iron regulatory protein was demonstrated in the brain microvasculature and the activity of this protein is decreased in restless legs syndrome; a finding similar to our earlier report in neuromelanin cells from the substantia nigra of restless legs syndrome brains. This study reveals that there are alterations in the iron management protein profile in restless legs syndrome compared with controls at the site of blood-brain interface suggesting fundamental differences in brain iron acquisition in individuals with restless legs syndrome. Furthermore, the decrease in transferrin receptor expression in the microvasculature in the presence of relative brain iron deficiency reported in restless legs syndrome brains may underlie the problems associated with brain iron acquisition in restless legs syndrome. The consistent finding of loss of iron regulatory protein activity in restless legs syndrome brain tissue further implicates this protein as a factor in the underlying cause of the iron deficiency in the restless legs syndrome brain. The data herein provide evidence for regulation of iron uptake and storage within brain microvessels that challenge the existing paradigm that the blood-brain barrier is merely a transport system.
answer:
Which deficiency is the cause of restless leg syndrome?


question:
Clay gets up from his trailer at the beach and drives to Mr. Jimmy's lush house, where he mows the lawn.Mr. Jimmy has a visit from David, who is concerned about his health. He then goes out to chat with Clay, his new gardener, and invites him to swim in the pool after he is done working. Clay says he needs to do another lawn later.An academic named Edmund Kay comes to visit Mr. Jimmy, and expresses his deep enthusiasm for his films. Jimmy takes him out back to the pool, and recalls his youth in London, and then his movement into movies and on to Hollywood.Mr. Jimmy becomes bored with Kay's questions, and suggests that Kay begin removing clothing in exchange for his answers. Kay begins disrobing to each of Jimmy's tales about homosexuals in Hollywood and making Frankenstein.Jimmy then gets lightheaded and needs Kay's help to get inside and lie down. His maid Hanna scolds him for chasing boys after just returning from the hospital.Jimmy goes to a doctor who explains that he had a stroke which has left his brain somewhat impaired.Jimmy sees Clay working out in the garden and invites him to talk over iced tea in his painting studio. Jimmy tells him he directed the first two Frankenstein movies, and they talk about his paintings. Jimmy tells Clay he has an expressive head and asks him to model for pay; Clay agrees.Clay arrives at Jimmy's house and Hanna asks if he is going to hurt him. Clay is confused, and she withdraws the question. Clay sits down in the studio to model for Jimmy, who asks him to remove his shirt, even though he only plans to draw his face. Jimmy begins to draw, telling Clay of a memory he has about eating fat drippings as a poor child. He explains how different he was from his family, more talented, more intelligent.Clay goes to a bar and boasts that a famous director is drawing him. Betty the bartender, whom Clay has slept with, turns on The Bride of Frankenstein on TV; meanwhile, Jimmy watches at home with Hanna. The others at the bar criticize the film for not being scary. Clay seems to understand the monster's feelings of loneliness.Flashback: Jimmy directs the performers on the set of Bride of Frankenstein.Clay and Betty talk outside the bar, and he gets upset that she does not want to sleep with him again.Clay calls his parents from a payphone but does not want to talk much.Jimmy dreams that Clay is Dr. Frankenstein, replacing his brain and electrifying him.Hanna tells Clay that Jimmy would like him to have lunch. The two talk as she cooks, and Hanna tells him he should be married. Hanna tells Clay that Jimmy commits unspeakable sins of the flesh, buggery. She is surprised that Clay did not know.Jimmy and Clay have a rather fancy lunch. Jimmy tells Clay that he had hoped Bride of Frankenstein would be seen as a comedy. Jimmy asks Clay to pose for an hour after lunch, and he declines. Jimmy explains that he had a "husband" named David, and Clay asks about his homosexuality. They smoke cigars, and Clay agrees to pose.During the sitting, Jimmy talks about how he made the successful Show Boat and then tried to make his WWI masterpiece The Road Back but the studio butchered it. He says he always wanted to go back to movies, but that was the end. He also broke up with David thereafter. Jimmy begins to describe how he used to have many male models, all naked, which upsets Clay so much he gets mad and storms out.Clay goes to Betty's bar but she is not there. He finds another woman and has sex with her in the parking lot.Clay returns to Jimmy's house and says he will sit for him again if he eases up on the locker room talk. Jimmy is curious that Clay has never known any gay men before, not even when he was in the Marines. Jimmy recalls a young soldier from WWI he mentored in the trenches, then becomes quite upset, looking at Clay intensely
answer:

Who is befriend with handsome gardener and former Marine?