instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Coming off their road win over the Packers, the Falcons went home for a Week 6 duel with the Chicago Bears. In the first quarter, Atlanta took flight as kicker Jason Elam got a 29-yard and a 48-yard field goal. In the second quarter, the Falcons increased their lead as Elam kicked a 32-yard field goal. The Bears would respond with kicker Robbie Gould getting a 36-yard field goal.Entering Sunday game with the Bears, the Falcons led the NFL in first quarter scoring with 48 points. After posting two field goals for a 6-0 lead following the first 15 minutes of play against Chicago, Atlanta has now outscored its opponent in the first quarter by a 54-14 margin. A chance at a touchdown came with 9:16 remaining in the first half after a curious turn of events near the goal line. A third-down run by Jerious Norwood came up short and ended with a fumble. Bears defensive tackle Tommie Harris recovered but lost the ball before he was touched down. Jason Snelling recovered the ball for the Falcons, who got a fresh set of downs. Following the first half of play, the Falcons defense held the Bears to 20 first half rushing yards. The 20 yards are the fewest given up in the first half of a game by Atlanta's defense since October 1, 2006, against Arizona (two yards). In the third quarter, the Falcons continued to add onto their lead as Elam got a 41-yard field goal, yet Chicago answered with RB Matt Forte getting a 3-yard TD run. In the fourth quarter, Atlanta replied with rookie quarterback Matt Ryan completing a 3-yard TD pass to WR Roddy White. Defensive end Jamaal Anderson paced a defense that fed off the crowd's energy. He finished with four tackles (two for loss) and the first sack of his two-year career. Anderson also had two pass deflections on the Bears' first drive of the second quarter.The Falcons offense started the second half with a no-huddle offense and added another Elam field goal to take a 12-3 lead. Chicago stuck with the running game and added a touchdown from Forte with 2:24 remaining in the third quarter. Chicago drove within inches of the end zone, but Matt Forte was stuffed on fourth down as he attempted to leap across the line. Michael Boley came in low to trip up the runner, then Lawyer Milloy and Keith Brooking finished him off.The Bears took the lead with Gould getting a 32-yard field goal, along with quarterback Kyle Orton completing a 17-yard TD pass to WR Rashied Davis. Fortunately, the Falcons got the last laugh as Elam nailed the game-winning 48-yard field goal.The 16-year veteran's celebration was interrupted by a swarm of teammates near midfield. It was his fifth successful kick of the day but just moments before he missed a kick that could have iced the game. Chicago came off the miscue with a 77-yard touchdown drive to take a 20-19 lead with 11 seconds to play. But a 9-yard return off a short kickoff by Harry Douglas and a 26-yard strike from rookie quarterback Matt Ryan to Michael Jenkins set Elam up for the game-winner with 1 second left. "I'm really happy that one went through", Elam said. "Our guys have been fighting so hard for so long. I hate to even mention what happened last year but to hear some of the stories I know the guys are really hungry to get some wins on the board and show our fans what we're all about." With time to throw Ryan thrived. The rookie found five different receivers and performed regular Houdini-like acts to find open players down the field for third-down conversions. Fellow rookie Douglas caught five passes for 96 yards including a 47-yard strike on third down that set up a 3-yard scoring toss to White with 13:25 remaining.Ryan opened the game 8-of-8 for 107 yards and captained nearly identical scoring drives in the first quarter, leading the team on 48- and 49-yard marches that ended with field goals."I think everybody is excited with the win", Ryan said. "I thought we played a very good Chicago Bears team today
answer:
Which distance did Elam kick two field goals from?


question:
Nuclear receptor co-repressor (N-CoR) plays important role in transcriptional control mediated by several tumor suppressor proteins. Recently, we reported a role of misfolded-conformation dependent loss (MCDL) of N-CoR in the activation of oncogenic survival pathway in acute promyelocytic leukemia (APL). Since N-CoR plays important role in cellular homeostasis in various tissues, therefore, we hypothesized that an APL like MCDL of N-CoR might also be involved in other malignancy. Indeed, our initial screening of N-CoR status in various leukemia and solid tumor cells revealed an APL like MCDL of N-CoR in primary and secondary tumor cells derived from non-small cell lung cancer (NSCLC). The NSCLC cell specific N-CoR loss could be blocked by Kaletra, a clinical grade protease inhibitor and by genistein, an inhibitor of N-CoR misfolding previously characterized by us. The misfolded N-CoR presented in NSCLC cells was linked to the amplification of ER stress and was subjected to degradation by NSCLC cell specific aberrant protease activity. In NSCLC cells, misfolded N-CoR was found to be associated with Hsc70, a molecular chaperone involved in chaperone mediated autophagy (CMA). Genetic and chemical inhibition of Lamp2A, a rate limiting factor of CMA, significantly blocked the loss of N-CoR in NSCLC cells, suggesting a crucial role of CMA in N-CoR degradation. These findings identify an important role of CMA-induced degradation of misfolded N-CoR in the neutralization of ER stress and suggest a possible role of misfolded N-CoR protein in the activation of oncogenic survival pathway in NSCLC cells.
answer:
Which is the receptor for substrates of Chaperone Mediated Autophagy?


question:
We have investigated the contribution of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) and mitogen-activated protein kinase (MAP kinase) in norepinephrine (NE)-induced arachidonic acid (AA) release in rabbit aortic vascular smooth muscle cells (VSMC). NE enhanced release of AA via activation of cytosolic phospholipase A2 (cPLA2) but not secretory PLA2 in VSMC prelabeled with [3H]AA. NE (10 microM) enhanced CaM kinase II and MAP kinase activity. In cells transiently transfected with antisense oligonucleotides complementary to the translation initiation sites of CaM kinase II and MAP kinase, NE-induced AA release was inhibited by 100 and 35% respectively. Treatment of cells with PD-098059, a MAP kinase kinase inhibitor, or with MAP kinase antisense oligonucleotide reduced NE-induced activation of MAP kinase and cPLA2. NE-induced MAP kinase and cPLA2 activation was also inhibited in cells treated with a CaM kinase II inhibitor, KN-93, or with CaM kinase II antisense oligonucleotide. On the other hand, inhibition of MAP kinase kinase with PD-098059 or of MAP kinase with antisense oligonucleotides did not alter the NE-induced increase in CaM kinase II activity. Phosphorylation of MAP kinase and CaM kinase II by NE, studied by 32P incorporation and immune complex kinase assays, was inhibited by KN-93. Collectively, these data suggest that CaM kinase II can activate MAP kinase, which in turn activates cPLA2 to release AA for prostacyclin synthesis in the rabbit VSMC. This novel pathway for activation of MAP kinase by CaM kinase II appears to be mediated through stimulation of MAP kinase kinase. Activation of adrenergic receptors with NE in VSMC caused translocation of CaM kinase II, MAP kinase, and cPLA2 to the nuclear envelope only in the presence of extracellular Ca2+. Okadaic acid, which increased phosphorylation and activity, did not translocate these enzymes. Therefore, it appears that in rabbit VSMC, NE, by promoting extracellular Ca2+ influx, increases CaM kinase II activity, leading to activation of MAP kinase and cPLA2 and translocation to the nuclear envelope, resulting in release of AA from the nuclear envelope for prostacyclin synthesis.
answer:

Which kinase is inhibited by the small molecule KN-93?