Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
--------
Question: Context: On July 15, 2009 Nucleosys was announced to be disbanding. 
 Question: What year was the end of Nucleosys?

Answer: 2009


Question: Context: Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia chromosome, which is associated with a balanced translocation involving chromosomes 9 and 22 to produce a fusion gene (bcr-abl) that gives rise to a constitutively activated Abl tyrosine kinase. This kinase led to the discovery of several small-molecule inhibitors, imatinib being the first and most successful of these. Resistance to imatinib results in some patients from Abl kinase point mutations. Overcoming imatinib resistance represents one of the biggest challenges facing clinicians in the modern management of CML. In this review, we discuss the current understanding of CML pathophysiology and mechanisms of imatinib resistance and how advancing this knowledge has led to the design of novel therapies in the area of blastic phase CML and Philadelphia chromosome-positive acute lymphoblastic leukemia with previous imatinib failure. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

Answer: bcr-abl


Question: Context: The Giants failed to capitalize on their win from the week before and once again were defeated by the Redskins for the season sweep. Washington never trailed in this game and forced Eli Manning into three interceptions. Although the Giants recorded two off of Rex Grossman, they never were able to get into any sort of offensive groove and lost 23-10. Washington led 17-3 at halftime and never looked back. Grossman threw for 185 yards and a touchdown to Santana Moss. Jabar Gaffney led the Redskins with 85 yards receiving while Hakeem Nicks recorded 73 for the Giants. Manning finished with 257 yards. 
 Question: Which quarterback threw for at least 200 yards?

Answer:
eli manning