In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

[EX Q]: Question: Which of these statements is NOT a characteristic of phase I clinical trials? 
 Options:  <1> They usually have non-therapeutic goals. <2> They can be done in healthy volunteers. <3> They can be done in patients. <4> They are usually randomized. <5> They are usually open.
[EX A]: 4

[EX Q]: Question: In the synthesis of DNA, the quinolones act: 
 Options:  <1> Joining the double helix and thus blocking the progress of the replication fork. <2> Interlacing in the double helix and thus causing errors in the transcription. <3> On DNA gyrase. <4> As nucleotide analogs that are incorporated into DNA. <5> About DNA polymerases.
[EX A]: 3

[EX Q]: Question: Pyridoxal phosphate is a prosthetic group of enzymes involved in reactions of: 
 Options:  <1> Acetylation <2> Desulfation. <3> Methylation <4> Reduction. <5> Transamination.
[EX A]:
5