TASK DEFINITION: Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
PROBLEM: Context: Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, demonstrated efficacy and safety in moderate-to-severe plaque psoriasis when administered via subcutaneous injection. Self-administration by pre-filled syringe (PFS) can offer patients clinical benefits of a drug, with increased convenience. To assess efficacy, safety and usability of secukinumab administration via PFS in subjects with moderate-to-severe plaque psoriasis. Subjects in this phase 3 trial were randomized 1:1:1 to secukinumab 300 or 150mg or matching placebo. Results to week 12 are presented here. Each treatment was delivered using a PFS once weekly to week 4, and again at week 8. Co-primary endpoints were secukinumab superiority over placebo for week 12 PASI 75 (75% reduction in Psoriasis Area and Severity Index) and IGA mod 2011 (2011 modified Investigator's Global Assessment) 0/1 response rates. Secondary endpoints included PFS usability, determined by observer rating of successful, hazard-free self-injection and subject rating of acceptability by the Self-Injection Assessment Questionnaire (SIAQ). Co-primary endpoints were met, with demonstration of superiority for each secukinumab dose vs. placebo at week 12 (PASI 75: 759%, 695% and 0% for secukinumab 300mg, 150mg and placebo; IGA mod 2011 0/1: 690%, 525% and 0%, respectively; P<00001 for all comparisons vs. placebo). PFS usability was high: 100% of subjects successfully self-administered treatment at week 1, and subjects reported high SIAQ-assessed acceptability of the PFS throughout the trial. No new/unexpected safety signals were observed. Secukinumab administration by PFS was effective, with an acceptable safety profile and high usability. The PFS provides a reliable, convenient form of secukinumab administration in subjects with moderate-to-severe plaque psoriasis. 
 Question: Which molecule is targeted by a monoclonal antibody Secukinumab?

SOLUTION: interleukin-17a

PROBLEM: Context: The Conquest of Melilla occurred in September 1497, when a fleet sent by the Duke of Medina Sidonia seized the north African city of Melilla., as continuation of Reconquest of Mauritania Tingitana During the 15th century the mediterranean cities of the Sultanate of Fez fell in decadence in opposition to cities located in the Atlantic facade, which concentrated most of the economic activity. By the end of the 15th century, the port of Melilla, that had been often disputed between the rulers of Fez and Tlemcen, was nearly abandoned. Plans for the conquest occurred as soon as the Fall of Granada in 1492. Spanish captains Lezcano and Lorenzo Zafra visited the coast of Northern Africa to identify possible locations for the Spanish to overtake, and Melilla was identified as a prime candidate. Melilla was, however, in the Portuguese zone of influence under the terms of the 1479 Treaty of Alcacovaz. At Tordesillas in 1494, King John II of Portugal, the Portuguese ruler agreed to make an exception and permitted the Spanish to attempt the conquest of Melilla. The duke sent Pedro Estopinan who conquered the city virtually without a fight in 1497, as internal conflicts had depleted it of troops, and its defenses were weakened. The Wattasid ruler Muhammad al-Shaykh sent a detachment of cavalrymen to retake control of the city, but they were repulsed by the guns of the Spanish ships. 
 Question: Which happened first, the fleet being sent by the Duke of Medina, or the Conquest of Melilla?

SOLUTION: fleet sent by the duke

PROBLEM: Context: In the mid 1900s, people were startled to see the Cuyahoga River in Cleveland, Ohio, burst into flames! The river was so polluted with oil and other industrial wastes that it was flammable. Nothing could live in it. You can see the Cuyahoga River in Figure 21.16 Disasters such as rivers burning led to new U.S. laws to protect the water. For example, the Environmental Protection Agency (EPA) was established, and the Clean Water Act was passed. Now, water is routinely tested. Pollution is tracked to its source, and polluters are forced to fix the problem and clean up the pollution. They are also fined. These consequences have led industries, agriculture, and communities to pollute the water much less than before. Most water pollution comes from industry, agriculture, and municipal sources. Homes are part of the municipal source and the individuals and families that live in them can pollute the water supply. What can you do to reduce water pollution? Read the tips below. Properly dispose of motor oil and household chemicals. Never pour them down the drain. Also, dont let them spill on the ground. This keeps them out of storm sewers and bodies of water. Use fewer lawn and garden chemicals. Use natural products instead. For example, use compost instead of fertilizer. Or grow plants that can thrive on their own without any extra help. Repair engine oil leaks right away. A steady drip of oil from an engine can quickly add up to gallons. When the oil washes off driveways and streets it can end up in storm drains and pollute the water supply. Dont let pet litter or pet wastes get into the water supply (see Figure 21.17). The nitrogen they contain can cause overgrowth of algae. The wastes may also contain bacteria and other causes of disease. Water treatment is a series of processes that remove unwanted substances from water. The goal of water treatment is to make the water safe to return to the natural environment or to the human water supply. Treating water for other purposes may not include all the same steps. Thats because water used in agriculture or industry may not have to be as clean as drinking water. You can see how water for drinking is treated in Figure 21.18. Treating drinking water requires at least four processes: 1. Chemicals are added to untreated water. They cause solids in the water to clump together. This is called coagulation. 2. The water is moved to tanks. The clumped solids sink to the bottom of the water. This is called sedimentation. 3. The water is passed through filters that remove smaller particles from the water. This is called filtration. 4. Chlorine is added to the water to kill bacteria and other microbes. This is called disinfection. Finally, the water is pure enough to drink. Conserving water means using less of it. Of course, this mostly applies to people in the wealthy nations that have the most water and also waste the most. Irrigation is the single biggest use of water. Overhead irrigation wastes a lot of water. Drip irrigation wastes a lot less. Figure 21.19 shows a drip irrigation system. Water pipes run over the surface of the ground. Tiny holes in the pipes are placed close to each plant. Water slowly drips out of the holes and soaks into the soil around the plants. Very little of the water evaporates or runs off the ground. Some communities save water with rationing. Much rationing takes place only during times of drought. During rationing, water may not be used for certain things. For example, communities may ban lawn watering and car washing. People may be fined if they use water in these ways. You can do your part. Follow any bans where you live. Its easy to save water at home. If you save even a few gallons a day you can make a big difference over the long run. The best place to start saving water is in the bathroom. Toilet flushing is the single biggest use of water in the home. Showers and baths are the next biggest use. Follow the tips below to save water at home. Install 
 Question: The single biggest use of water in the home is

SOLUTION:
toilet flushing.