TASK DEFINITION: Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.
PROBLEM: The U.S. Food and Drug Administration questioned the differences in size and formulation of the patch used in trials and the to-be-marketed patch. The generic drugs maker, which received a “complete response letter” from the FDA, said it planned to work closely with the agency to address the questions. Such letters typically lay out FDA concerns that need to be addressed before a treatment is approved. Actavis’ contraceptive skin patch is designed to provide continuous delivery of the hormone norethindrone, a type of progestin, during a once-weekly, seven-day dosing regimen. Progestin, the synthetic form of female sex hormone progestogen, inhibits ovulation and thickens the layer of mucus at the cervix so sperm cannot enter the uterus. The treatment will compete with Johnson and Johnson’s Ortho Evra, an estrogen/progestin combination contraceptive patch. Estrogen is another female sex hormone. A progestin-only patch can be safer than combination patches as high levels of estrogen are often linked to blood clotting disorders and an increased risk of cancer. The company also filed on Tuesday an application to market the generic version of Merck & Co Inc’s NuvaRing, a estrogen/progestin combination hormonal contraceptive vaginal ring. Actavis said it may be the first applicant to file the application, which, if approved may entitle it to 180 days of generic market exclusivity. Shares of Dublin, Ireland-based Actavis were down 0.6 percent at $165.16 in early trading on the New York Stock Exchange on Tuesday.

SOLUTION: FDA rejects Actavis' contraceptive patch, seeks more data.

PROBLEM: Monsoon rains and rising rivers submerged a dozen districts in the greater Jakarta area starting Wednesday after extreme torrential rains hit on New Year’s Eve, causing landslides in hilly areas on the outskirts of the capital that buried scores of people. It’s the worst flooding in the area since 2007, when 80 people were killed over 10 days. More than a thousand soldiers and health workers sprayed disinfectant in hard-hit areas on Sunday to anticipate possible diseases spread by flooding, such as dengue and leptospirosis, a potentially fatal disease spread by rat’s urine, said Ridwan Carman, who is in charge of emergency response and recovery for the Indonesian Red Cross. About 11,000 health workers were deployed to provide medical care for people affected by the flooding, Health Minister Terawan Agus Putranto said in a statement. He said there had been no recorded cases of leptospirosis, tetanus or serious waterborne diseases. In Lebak, a district in neighboring Banten province, where flash floods and mudslides swept away more than 1,700 houses and destroyed several villages, rescuers were still searching for a 7-year-old boy reportedly dragged away by flash flooding that killed at least nine people, said Zainal Arifin, a local search and rescue agency chief. He said mudslides that covered much of the area, blackouts and lack of telecommunications were hampering the search efforts. Indonesian President Joko Widodo on Sunday failed to meet survivors in the devastated village of Sukajaya, where the highest number of deaths were reported, as his helicopter was unable to land due to bad weather, the presidential secretariat said in a statement. The village is in the hardest-hit district of Bogor, where 16 people were killed by flash floods and landslides. Waters have receded in most parts of greater Jakarta, allowing many residents to return and clean up, but scores of tightly packed settlements close to rivers that often suffer from floods during the rainy season remained inundated or covered in mud and debris. Tens of thousands of people remained crammed in damp shelters, mostly in western Jakarta and its satellite city of Bekasi. Government data on Sunday showed that some 92,200 people were still unable to return home as the filthy waters submerged their houses up to 1.5 meters (5 feet) high. In a cramped and damp emergency shelter at a sports center in south Jakarta, mothers breast fed their babies near piles of smelly wet garbage. “My baby is not sleeping as the rain comes in, the wind comes in,” Yuyun Yuniarti said while holding her 7-month-old baby in a sling. “It is disgusting here, but we are stuck.” Yuniarti said food and medicine appeared to be sufficient, with most shelters visited in recent days by authorities and private organizations delivering regular supplies of food. A temporary clinic was treating patients close to where Yuniarti was sleeping, including many suffering from respiratory illnesses. Save the Children, an international child rights organization, expressed its concern about the dire situation for children. At least six kids have died from the floods and tens of thousands have had to leave their homes in Jakarta. “We call on all involved to make sure children are kept safe and have a roof over their heads, and food to eat,” Dino Satria, Save the Children’s humanitarian director in Indonesia, said in a statement. He said his organization would provide school kits, tents and hygiene kits to prevent the outbreak of diseases. Indonesia’s Meteorology, Climatology and Geophysics Agency said that more downpours were forecast for the capital in the coming days, and that the potential for extreme rainfall would continue until next month across the vast archipelago nation. The government on Friday started cloud seeding in an attempt to divert rain clouds from reaching greater Jakarta to prevent possible flooding, the agency said. Indonesia is hit by deadly floods each year, and Jakarta, the capital of Southeast Asia’s largest economy, is not immune. But this year’s floods have been particularly bad, with nearly 400,000 people seeking refuge in some 270 shelters across the greater metropolitan area as floodwaters reached up to 6 meters (19 feet) in some places.

SOLUTION: Indonesia’s flooded capital disinfected to fend off disease.

PROBLEM: Surgeons performed the transplant on 11-year-old Sofia Sanchez on Monday at Chicago’s Lurie Children’s Hospital. The Canadian rapper visited Sofia there after seeing a video of her dancing in a hospital hallway to his song, “In My Feelings.” The video inspired a viral dance craze. Cardiovascular surgeon Carl Backer says Sofia’s nine-hour surgery went extremely well, although the first 48 hours after are critical. A Facebook video shows Sofia being told of the transplant on Sunday and then exclaiming “I’m getting a heart, Mom? Oh my God!” ___ This story has been corrected to show that the surgery took nine, not 12 hours.

SOLUTION:
11-year-old girl gets heart transplant after visit by Drake.