instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder resulting in the growth of a variety of tumours, and is inherited in an autosomal dominant pattern. Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours that commonly harbour oncogenic mutations in KIT or PDGFRA and are thought to arise from the interstitial cells of Cajal (ICC; the pacemaker cells of the gut). To characterise two patients with NF1 and GISTs. Two patients were genotyped for germline mutations in NF1. GISTs from both patients were genotyped for somatic mutations in KIT and PDGFRA. Loss of heterozygosity (LOH) of NF1 in one GIST was assessed by genotyping seven microsatellite markers spanning 2.39 Mb of the NF1 locus in the tumour and in genomic DNA. The known germline mutation in NF1 was confirmed in GIST DNA by sequencing. The copy number of the mutated NF1 allele was determined by multiplex ligand-dependent probe amplification. GISTs from both patients were of wild type for mutations in KIT and PDGFRA. In the GIST with adequate DNA, all seven markers were informative and showed LOH at the NF1 locus; sequencing of NF1 from that GIST showed no wild-type sequence, suggesting that it was lost in the tumour. Multiplex ligand-dependent probe amplification analysis showed that two copies of all NF1 exons were present. This is the first evidence of mitotic recombination resulting in a reduction to homozygosity of a germline NF1 mutation in an NF1-associated GIST. We hypothesise that the LOH of NF1 and lack of KIT and PDGFRA mutations are evidence of an alternative pathogenesis in NF1-associated GISTs.
answer:
Which is the gene mutated in type 1 neurofibromatosis?


question:
Fafhrd and the Gray Mouser are two sword-and-sorcery heroes appearing in stories written by American author Fritz Leiber.
answer:
Who is the author of Fafhrd and the Gray Mouser?


question:
An alloy is a mixture of a metal with one or more other elements. The other elements may be metals, nonmetals, or both. An alloy is formed by melting a metal and dissolving the other elements in it. The molten solution is then allowed to cool and harden. Alloys generally have more useful properties than pure metals. Several examples of alloys are described and pictured below. If you have braces on your teeth, you might even have this alloy in your mouth! Click image to the left or use the URL below. URL: Most metal objects are made of alloys rather than pure metals. Objects made of four different alloys are shown in the Figure 1.1. Brass saxophone: Brass is an alloy of copper and zinc. It is softer than bronze and easier to shape. Its also very shiny. Notice the curved pieces in this shiny brass saxophone. Brass is used for shap- ing many other curved objects, such as doorknobs and plumbing fixtures. Stain- less steel sink: Stainless steel is a type of steel that contains nickel and chromium in addition to carbon and iron. It is shiny, strong, and resistant to rusting. This makes it useful for sinks, eating utensils, and other objects that are exposed to wa- ter. "Gold" bracelet: Pure gold is relatively soft, so it is rarely used for jewelry. Most "gold" jewelry is actually made of an alloy of gold, copper and silver. Bronze statue: Bronze was the first alloy ever made. The earliest bronze dates back many thou- sands of years. Bronze is a mixture of copper and tin. Both copper and tin are relatively soft metals, but mixed together in bronze they are much harder. Bronze has been used for statues, coins, and other objects. Q: Sterling silver is an alloy that is used to make fine jewelry. What elements do you think sterling silver contains? What properties might sterling silver have that make it more useful than pure silver? A: Most sterling silver is about 93 percent silver and about 7 percent copper. Sterling silver is harder and stronger than pure silver, while retaining the malleability and luster of pure silver.
answer:

the first alloy ever made was