instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Penobscot tribal chiefs expressed a willingness to enter peace talks with Lieutenant Governor Dummer in December 1724. They were opposed in this by French authorities, who continued to encourage the conflict, but Massachusetts Lieutenant Governor Dummer announced a cessation of hostilities on 31 July 1725 following negotiations in March.:83 The terms of this preliminary agreement were negotiated by Dummer and Chiefs Loron and Wenemouet and applied only to the Penobscots at first. They were allowed to retain Jesuit priests, but the two parties were in disagreement concerning land titles and British sovereignty over the Wabanakis. The written agreement was translated into Abenaki by French Jesuit Etienne Lauverjat; Chief Loron immediately repudiated it, specifically rejecting claims of British sovereignty over him. Despite his disagreement, Loron pursued peace, sending wampum belts to other tribal leaders, although his envoys were unsuccessful in reaching Gray Lock, who continued his raiding expeditions. Peace treaties were signed in Maine on 15 December 1725 and in Nova Scotia on 15 June 1726, involving a large number of tribal chiefs. The peace was reconfirmed by all except Gray Lock at a major gathering at Falmouth in the summer of 1727; other tribal envoys claimed that they were not able to locate him. Gray Lock's activity came to an end in 1727, after which time he disappears from English records.
answer:
At what event was Gray Lock discovered to be missing?


question:
The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein tau. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds tau with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the tau-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10(-9) M MAP2c and 10(-8) M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and tau might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease.
answer:
Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?


question:
OUR KIDS ARE AMAZING-especially compared with everybody else's (who seem to cry all the time). How do you show your love for your kids this holiday season? With toys that are smooth and colorful, interactive and exciting. And with ones that have educational value-because you are the boss. 1. FLAX ART HOSPITAL PUZZLE AND PLAY SET Here is a toy that doesn't need power-and the bike have to put it together themselves. This 50 piece puzzle set is made of soft edged hardwood and makes a complete hospital, with an X ray room. It also includes eight patients, a car and a driver. $135; flaxart.com. 2. TINY LOVE ACTIVITY BALL Sure, it's cool, but this colorful baby toy also develops problem solving and motor skills. It has a head and legs, a magnetic hand and a tail. Suitable for little ones from 6 to 36 months. $19.95; tinylove.com. 3. ROBOSAPIEN This small, remote control robot is really powerful. It performs 67 preprogrammed functions , including throwing, kicking, picking up and dancing. You can even program your own function which, sadly, does not include doing windows. $99; robosapienonline.com. 4. MINI PEDAL CAR Want a Mini Cooper but can't fit the family inside? Get one for the kids. They can jump into this Mini car, which comes in hot orange with a single adjustable seat, and ride away. But it could spoil them for that used car they'll be driving when they turn 16.For ages 3 to 5.$189; minus A. com (click on "gear up," then "Mini motoring gear").
answer:

Which toy is said to have the special design for children's safety?