Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Spleen tyrosine kinase (Syk) is a cytoplasmic tyrosine kinase involved in signalling in many of the cells that drive immune inflammation. The development of small molecules that inhibit Syk kinase may change the way we treat disorders such as rheumatoid arthritis (RA), as well as a range of other inflammatory diseases. Fostamatinib (R-788) is an orally bioavailable small molecule. It is the prodrug of R406, which is a potent Syk inhibitor. Fostamatinib was developed because it has more favourable physiochemical properties. It is rapidly converted to R406 by intestinal enterocytes. It has been evaluated in experimental models of RA, such as collagen-induced arthritis. In these models, fostamatinib suppressed clinical arthritis, bone erosions, pannus formation and synovitis. A phase II programme with fostamatinib has largely been completed. Three key trials have been published, lasting 12-26 weeks and each enrolling 189-457 patients (875 in total). All these trials involved placebo therapy and patients continued to receive methotrexate in addition to active treatment with fostamatinib. The first dose-ranging trial evaluated three treatment doses in RA patients who had not fully responded to methotrexate therapy. The second trial compared two treatment doses in patients who had not responded to methotrexate therapy. The third trial compared a single treatment dose with placebo in patients who had not responded to biological therapy. The primary outcome measure was the number of patients achieving American College of Rheumatology (ACR) 20% (ACR20) responses. Placebo ACR20 response rates in all three trials were similar (35-38%). All three trials involved one treatment arm receiving fostamatinib 100 mg twice daily; ACR20 responses with this active treatment ranged from 38% to 67%. A meta-analysis of ACR responses in these trials, using responses to the highest dose in each trial for comparisons with placebo therapy in a random effects model, showed a borderline benefit with ACR20 responses. There were more significant differences with ACR50 and ACR70 responses. The reason that this meta-analysis was not more strongly positive is that the third trial, which evaluated patients who had failed to respond to biological treatments, gave negative results. Individual ACR response components, such as changes in swollen joint counts, showed significant differences in the first two trials, but there were no definite treatment benefits in the third trial. Overall, the differences were significant in a meta-analysis of all three trials. The most important adverse reactions were diarrhoea, neutropenia and raised ALT levels, which all showed significant excesses with active treatment compared with placebo. Too few patients have been studied for a definitive safety profile to be known. Overall, the results of the phase II trials were sufficiently encouraging for a phase III programme to be initiated. It will be some years before their definitive results are available.

Answer: Which enzyme is inhibited by a drug fostamatinib?


Question: Almost all surfaces reflect some of the light that strikes them. The still water of the lake in Figure 22.9 reflects almost all of the light that strikes it. The reflected light forms an image of nearby objects. An image is a copy of an object that is formed by reflected or refracted light. If a surface is extremely smooth, like very still water, then an image formed by reflection is sharp and clear. This is called regular reflection. If the surface is even slightly rough, an image may not form, or if there is an image, it is blurry or fuzzy. This is called diffuse reflection. Both types of reflection are represented in Figure 22.10. You can also see animations of both types of reflection at this URL: [Link] In Figure 22.10, the waves of light are represented by arrows called rays. Rays that strike the surface are referred to as incident rays, and rays that reflect off the surface are known as reflected rays. In regular reflection, all the rays are reflected in the same direction. This explains why regular reflection forms a clear image. In diffuse reflection, in contrast, the rays are reflected in many different directions. This is why diffuse reflection forms, at best, a blurry image. One thing is true of both regular and diffuse reflection. The angle at which the reflected rays bounce off the surface is equal to the angle at which the incident rays strike the surface. This is the law of reflection, and it applies to the reflection of all light. The law is illustrated in Figure 22.11 and in the animation at this URL: Mirrors are usually made of glass with a shiny metal backing that reflects all the light that strikes it. Mirrors may have flat or curved surfaces. The shape of a mirrors surface determines the type of image the mirror forms. For example, the image may be real or virtual. A real image forms in front of a mirror where reflected light rays actually meet. It is a true image that could be projected on a screen. A virtual image appears to be on the other side of the mirror. Of course, reflected rays dont actually go behind a mirror, so a virtual image doesnt really exist. It just appears to exist to the human eye and brain. Most mirrors are plane mirrors. A plane mirror has a flat reflective surface and forms only virtual images. The image formed by a plane mirror is also life sized. But something is different about the image compared with the real object in front of the mirror. Left and right are reversed. Look at the man shaving in Figure 22.12. He is using his right hand to hold the razor, but his image appears to be holding the razor in the left hand. Almost all plane mirrors reverse left and right in this way. Some mirrors have a curved rather than flat surface. Curved mirrors can be concave or convex. A concave mirror is shaped like the inside of a bowl. This type of mirror forms either real or virtual images, depending on where the object is placed relative to the focal point. The focal point is the point in front of the mirror where the reflected rays intersect. You can see how concave mirrors form images in Figure 22.13 and in the interactive animation at the URL below. The animation allows you to move an object to see how its position affects the image. Concave mirrors are used behind car headlights. They focus the light and make it brighter. They are also used in some telescopes. The other type of curved mirror, a convex mirror, is shaped like the outside of a bowl. This type of mirror forms only virtual images. The image is always right-side up and smaller than the actual object, which makes the object appear farther away than it really is. You can see how a convex mirror forms an image in Figure 22.14 and in the animation at the URL below. Because of their shape, convex mirrors can gather and reflect light from a wide area. This is why they are used as side mirrors on cars. They give the driver a wider view of the area around the vehicle

Answer: Concave mirrors are used


Question: Conker's Bad Fur Day is an action-platform video game developed by Rare for the Nintendo 64 video game console.

Answer:
Which company developed the videogame Conker's Bad Fur Day?