Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

Question: Does the tissue Doppler imaging derived post-systolic velocity notch originate at the aortic annulus?
Answer: The AA represents the site of the earliest onset and maximal amplitude of the PSN on the longitudinal velocity curve suggesting its mechanism to be that of an energy release at the instant of the aortic valve closure causing an apically directed acceleration of the myocardium. A substantial number of healthy subjects exhibit a second PSN spike predominantly at the level of the AA. Its mechanism remains to be elucidated.
yes

Question: Does cYP3A5 genotype influence everolimus in vitro metabolism and clinical pharmacokinetics in renal transplant recipients?
Answer: This study provides direct and indirect evidence that CYP3A5 genotyping cannot help improve everolimus therapy.
no

Question: Is tertiary peritonitis ( recurrent diffuse or localized disease ) an independent predictor of mortality in surgical patients with intraabdominal infection?
Answer: We were unable to demonstrate, when compared to secondary peritonitis, that tertiary peritonitis is a significant independent predictor of mortality when other variables are taken into account. This suggests that the high mortality associated with tertiary peritonitis is more a function of the patient population in which it occurs than the severity of the pathologic process itself.

no