In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
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Question: ARTICLES We synthesized three overlapping 19-amino-acid peptides spanning the F binding domain of RhoA (amino acids 67-110) and used these to study the effect of peptides on virus-induced syncytium formation. Pretreatment of virus inoculum with the RhoA 77-95 peptide completely blocked plaque formation, whereas pretreatment with RhoA 87-105 did not have any effect on the plaque formation relative to media-treated controls (Fig. 1) . The RhoA 67-85 peptide did not block RSV-induced syncytium forma- by reduction of peak titer by 2 log 10 in RSV-infected mice. These findings indicate that the interaction between these two paramyxovirus fusion proteins and RhoA is an important target for new antiviral strategies.

Answer: A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3


Question: Background: Avian leukosis virus (ALV) is a major infectious disease that impacts the poultry industry worldwide. Despite intensive efforts, no effective vaccine has been developed against ALV because of mutations that lead to resistant forms. Therefore, there is a dire need to develop antiviral agents for the treatment of ALV infections and RNA interference (RNAi) is considered an effective antiviral strategy. Results: In this study, the avian leukosis virus subgroup J (ALV-J) proviral genome, including the gag genes, were treated as targets for RNAi. Four pairs of miRNA sequences were designed and synthesized that targeted different regions of the gag gene. The screened target (i.e., the gag genes) was shown to effectively suppress the replication of ALV-J by 19.0-77.3%. To avoid the generation of escape variants during virus infection, expression vectors of multi-target miRNAs were constructed using the multi-target serial strategy (against different regions of the gag, pol, and env genes). Multi-target miRNAs were shown to play a synergistic role in the inhibition of ALV-J replication, with an inhibition efficiency of viral replication ranging from 85.0-91.2%. Conclusion: The strategy of multi-target miRNAs might be an effective method for inhibiting ALV replication and the acquisition of resistant mutations.

Answer: Enhanced inhibition of Avian leukosis virus subgroup J replication by multi-target miRNAs


Question: 1. Data collection. Epidemiological data were collected from a variety of online sources. If we were able to find reports listing numbers of confirmed and suspected cases, we used that information. If the epidemiological curve was available online as a graph, which is the case for data obtained from the CDC (Centers for Disease Control and Prevention) and Eurosurveillance sites, we estimated numbers from the graph and matched the plot of the estimated data with the online source. This can conveniently be done in Excel by plotting our estimated numbers on a graph with a transparent background and superimposing the resulting plot on a copy of the epidemiological curve posted online. The data we used are available online at github.com/ JocelineLega/EpiGro. • Data for the 2014-15 chikungunya outbreak in the PAHO countries and territories were extracted from weekly reports published on the PAHO website (1), for the 71-week period from January 3, 2014 to May 8, 2015. Confirmed (autochthonous + imported) and suspected cases are included in this analysis. Not all countries provided weekly revisions of the total number of reported cases, leading to groups of consecutive data points with equal value. In the calculation of the outbreak growth rate, we use a time unit of one week. We do not compensate for the fact that the 53 rd week of 2014 has only 4 days; since the data are first smoothed and then interpolated, such a variation leads to a change in the instantaneous growth rate that is comparable to the size of uncertainties due to fluctuations in the number of reported cases, and is therefore negligible. Excel files with these data are provided for the Dominican Republic (CHIK Dom Rep.xlsx), Guadeloupe (CHIK Guadeloupe.xlsx), and Dominica (CHIK Dominica.xlsx).

Answer:
DATA-DRIVEN OUTBREAK FORECASTING WITH A SIMPLE NONLINEAR GROWTH MODEL TECHNICAL APPENDICES