Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

Example Input: Paragraph: The measure, which was the last bill taken up by the chamber before a key floor deadline Wednesday, passed on a 28-21 vote. It now heads to the House for consideration. Several groups would be included in the work group, including the public, community health advocates, businesses, health care providers, and state officials. The group would be tasked with determining how best to implement universal health care, and studying options for increasing coverage and access, options to expand health care purchasing in collaboration with neighboring states, and options on how to pay for such a system. The group would report its recommendations to the Legislature by Nov. 15, 2020. Claim: Washington Senate approves universal health care work group.
Example Output: The Washington Senate has passed a bill that would create a work group to study how universal health care could work in the state.

Example Input: Paragraph: The vote — which prompted environmental activists still in council chambers after four hours to break into applause — approved an ordinance that bans the transport, handling and storage of coal and petroleum coke at bulk material facilities or terminals in Oakland. “We want jobs that people can have, and have a long life and they don’t have to rely upon a job of desperation,” said Council President Lynette Gibson McElhaney after the vote. “I just believe that we can do better in Oakland.” The ordinance requires a second vote. City leaders have wrestled with the issue for more than a year, as detractors and supporters of the proposed marine terminal argued over the environmental dangers of bringing millions of tons of coal through the area and the economic benefits of good-paying union jobs. The terminal is part of a larger makeover of an army base that closed in 1999, eliminating thousands of jobs. The proposed terminal is in West Oakland, a historically black neighborhood that’s among the poorest and most polluted in the region. The council approved the project before the coal proposal was made. It’s uncertain whether the terminal will continue without shipping coal. A lawyer for the Oregon Bulk and Oversized Terminal on Monday sent the council a letter detailing potential legal consequences. “Politically, no quantity of handling coal or petcoke under whatever extraordinary standard will be tolerated,” said David Smith. “While that may accomplish a political outcome, it is only the first steps towards an unfortunate legal outcome.” City leaders said they were confident they could overcome a legal challenge. More than 150 people on both sides rallied outside the building Monday before the evening meeting. They packed the council’s chamber, cheering and booing as speakers testified. At times, it was so hard to hear speakers that the council president had to ask security to remove some people from the room. Coal proponents railed at the council for what they saw as a pre-ordained vote. They argued that any environmental impact would be mitigated by transporting coal in covered rail cars that are unloaded underground. “We agree 1,000 percent that West Oakland is polluted,” said Ron Muhammad, a fourth-generation resident of West Oakland. “But the project has a plan to mitigate it, to address it, so since the public health portion is taken out of the picture, then it goes back to the jobs.” On the other side, coal opponents argued there was no way to keep coal dust from escaping into the air, and that rail shipment would worsen the health of children already disadvantaged by poverty and bad air. “This whole notion of coal-covered cars is rather ridiculous to say the least because it’s never been done before,” said Derrick Muhammad of the International Longshore and Warehouse Union, which opposes the shipment of coal. Among the speakers were residents of Utah who were furious that their state lawmakers had pumped more than $50 million in public money to build the facility, hoping to spur investment in the state’s rural counties. Claim: Oakland council bans coal shipments, citing health risks.
Example Output: The Oakland City Council voted unanimously Monday night to kill a plan to use a proposed marine terminal to transport Utah coal to Asia, calling such shipments public health and safety hazards. Backers argued the project would bring needed jobs to an impoverished part of town.

Example Input: Paragraph: Called “biosimilars,” they are near-copies of complex and expensive biologic drugs to treat cancer, rare diseases and autoimmune disorders like rheumatoid arthritis and colitis. But U.S. sales have been so limited that their future is in doubt. Already, one company has scrapped nearly all its biosimilar development projects. Worst-case scenario? Drugmakers could abandon biosimilar development, and makers of original biologic drugs could keep raising their six-figure-a-year prices indefinitely. Two years ago, the independent policy research group RAND Health predicted biosimilars would save the U.S. roughly $54 billion from 2017 through 2026. That’s looking optimistic. “This is a make-or-break period,” said Dr. Scott Gottlieb, who led the Food and Drug Administration until April. “My fear is that some of the biosimilar-makers ... will say, ‘We’ll just go back to doing other things,’” and other drugmakers won’t enter the niche. Leigh Purvis, AARP’s director of health services research, says the original biologic drugmakers “could kill this market before it ever takes off, and we desperately need it.” THE PROMISE Biosimilars are akin to generic drugs, but true generics aren’t possible with biologic drugs. Pills are easily duplicated by mixing chemicals. Getting a generic version of a brand-name pill approved requires spending about $2 million and two years to conduct lab tests and show it’s chemically equivalent to the original medication. Manufacturing costs just pennies a pill. Biologic drugs, on the other hand, are made by manipulating living cells to produce a specific protein. They treat disorders often caused by faulty genes or immune systems, and they must be injected or delivered by infusion. The complex process needed to grow and purify the proteins means a copycat biosimilar will never be identical to the original drug. But it also can’t have “clinically meaningful” differences. Getting approval can take five to nine years of lab and patient testing, and cost over $100 million. A decade ago, Congress passed a law meant to encourage development of cheaper biosimilars. But the makers of the original biologic drugs have fought hard to block the new rivals, with stacks of successive patents, lawsuits and rebates to insurers. The result? Even drugmakers with the expertise and resources to produce biosimilars are mostly thwarted. In the U.S., that is. In Europe, monopoly-protecting patents generally don’t last as long as in the U.S. and government-run health systems have favored biosimilars in exchange for steep discounts. Biosimilars hit Europe in 2006. Now 54 are available at discounts up to 80 percent. In the U.S., the FDA has approved 24 biosimilars, nearly all since 2015. Just 11 of them are actually for sale, generally at 15% to 35% below the original drug’s price. Those discounts are easily matched by original biologic makers who prefer insurers give them a smaller piece of the pie than nothing. Biosimilars have been approved in the U.S. for five biologic best-sellers on the market as long as 22 years: Humira and Enbrel, for rheumatoid arthritis, psoriasis and other autoimmune disorders, and the cancer drugs Herceptin, Rituxan and Avastin. However, their biosimilars can’t be sold in the U.S. due to litigation and multiple, monopoly-extending patents. The brands have monthly list prices of over $5,000 to nearly $13,000. Health plans pay much less, but even well-insured patients must pay a big portion — or the full price until they cover their plan deductible. HOW WE GOT HERE Drugmakers have been harnessing scientific advances to create targeted biologic drugs, many for cancer and rare conditions without good treatments. Their executives predicted insurers wouldn’t balk at high prices because the patient numbers aren’t big. But as more people took biologic drugs and companies increased prices 6% to 20% every year, insurers and middlemen called prescription benefit managers limited patients’ access. They also set high copayments for many patients. Biosimilars were seen as financial salvation. But given their limited sales to date, the FDA is trying to enable faster approval. In May, it issued guidelines to enable biosimilar-makers to show their products are interchangeable with an original biologic drug. Pharmacies then could substitute a biosimilar for a brand-name biologic, as happens routinely with generic pills. Cancer patient David Mitchell, who founded the advocacy group Patients for Affordable Drugs, says biologic drugmakers are exploiting the system, despite having at least 12 years of market exclusivity. “We have patients who say, ‘I’ve been taking this drug for 15 or 20 years and there’s still no generic,’” Mitchell notes. He says the group also hears frequently from patients on biologic drugs “who are struggling or can’t afford them.” Chuck Pope, a former machinist from Derry, Pennsylvania, has had rheumatoid arthritis since 2005 and took Enbrel for seven years. He said it prevented flare-ups of the joint-destroying autoimmune disorder, enabling him to keep working long hours. Then shoulder injuries forced him onto disability and cost Pope his employer’s “excellent insurance.” Pope said he can’t afford the thousands of dollars Enbrel would cost him under his Medicare plan. “My body’s just totally disintegrating because of the RA,” which causes irreversible damage, said Pope, 64. “Wouldn’t it be more logical to lower the price and have more people on the drug?” BIOSIMILAR BARRIERS Last year, the U.S. spent $126 billion on biologic drugs, only 2% of it on biosimilars, according to the health data firm IQVIA. Gottlieb, the recently departed FDA commissioner, blames the slow uptake partly on doctors hesitant to switch patients to unfamiliar alternatives. He also points to barriers erected by the companies behind name-brand biologic drugs. Their tactics include disparaging biosimilars as inferior, luring patients with coupons subsidizing their copayments, getting successive patents to extend their monopolies, and giving rebates to insurance plans which cover their biologic drugs but exclude rival biosimilars. A report released Wednesday by a biosimilars trade group estimated the U.S. health care system lost $7.6 billion in possible savings since 2015 due to patent walls delaying sales of approved biosimilars. Health plans are reluctant to take up biosimilars, because that would instantly end their big rebates, Gottlieb said. Such exclusionary contracts have stifled sales of Inflectra, Pfizer’s biosimilar of Johnson & Johnson’s $5 billion-a-year autoimmune disorder drug, Remicade. Since launching in November 2016, Inflectra’s U.S. sales totaled $438 million, though it’s priced 25% below Remicade’s $2,335-per-month list price. Pfizer is suing J&J for “unlawful conduct” that blocks competition. J&J says it simply offered rebate options health plans requested. In October, biosimilar versions of the world’s most lucrative drug, Humira, hit Europe. Humira, which treats psoriasis, rheumatoid arthritis and other autoimmune disorders, launched 17 years ago and brought maker AbbVie $20 billion in 2018 sales, two-thirds from the U.S. Seven drugmakers have Humira biosimilars approved or awaiting approval in the U.S., but none are expected soon. AbbVie sued each rival to block sales, claiming they would infringe Humira patents. All seven companies eventually settled, agreeing to pay AbbVie royalties so they can start selling biosimilar versions — in 2023. Boehringer Ingelheim, the last company to settle, had alleged AbbVie “improperly created a ‘patent thicket,’ comprising more than a hundred overlapping and non-inventive patents, for the sole purpose of extending its monopoly far beyond the expiration of its core patent for Humira in 2016.” AbbVie wouldn’t discuss Humira. But at a September conference, Chief Financial Officer William Chase said, “You’ve seen us execute very nicely with our legal strategy” to delay U.S. competition. Meanwhile, AbbVie has raised Humira’s U.S. monthly list price from $1,524 in 2009 to $5,174, according to figures from health data firm Elsevier. Makers of Avastin, Herceptin, Rituxan and Enbrel likewise raised their list prices 50% to 200% over that decade. DIM FUTURE? Drugmakers are obligated to maximize profits for shareholders, and hiking prices in the U.S., where they make the lion’s share of revenue, is a sure way of helping their bottom line. Price experts including Dr. Peter Bach of Memorial Sloan Kettering Cancer Center in New York recently proposed scrapping biosimilars, saying they can’t succeed due to biologic drugs’ complexity and the nation’s for-profit health care system. They suggest that after biologic drugs have enjoyed their 12-year monopoly, their makers then sell them at cost plus a reasonable profit, set by an independent agency. Analyst Steve Brozak, president of WBB Securities, believes it will take another recession and a surge of unemployed, uninsured patients for the government to enact major changes to boost biosimilar use. Even if biosimilar access improves, few patients will see big savings, predicts Michael Kleinrock, research director at IQVIA. Insurers and prescription benefit managers will get those. “Many people will still have to pay up to their deductible” or out-of-pocket maximum, he says. Kleinrock sees bigger problems: Only about 20 biologic drugs have the billions in annual sales making it worthwhile to develop biosimilar rivals. And biosimilars of drugs created years ago will lose favor as improved, next-generation biologic medicines arrive. “If there’s less reward, there’s less incentive,” he says. ___ Follow Linda A. Johnson at https://twitter.com/LindaJ_onPharma ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. Claim: Future is in doubt for cheaper versions of biologic drugs.
Example Output:
They were the drugs that were supposed to save the U.S. tens of billions of dollars.