Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: To evaluate the role of apoptosis in the pathogenesis of brain lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary microangiopathy leading to cognitive decline and dementia, caused by mutations in the NOTCH3 gene. Detection of apoptotic nuclei in temporal lobe, brain stem, medulla oblongata, hippocampus and basal ganglia from one young CADASIL patient was performed by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling (TUNEL). Our results showed a great involvement of glial cells in apoptotic cell death in the majority of the brain regions examined; neuronal apoptosis was significantly present only in the brain stem region. We hypothesized that in the early stages of the disease neuronal involvement of apoptosis is limited to the cells of the brain stem, sparing the cortical area which is involved in neuronal apoptosis and cognitive decline later.

Answer: Which gene is involved in CADASIL?


Question: One Shell Square is a 51-story, 697-foot (212 m) skyscraper designed in the International style by Skidmore, Owings and Merrill, located at 701 Poydras Street in the Central Business District of New Orleans, Louisiana.

Answer: The designer for One Shell Square was?


Question: SAN FRANCISCO--The "Reading Wizard", an 11 - year - old - boy, whose offer to read to children without being paid at a local library was refused by libraries, will get to read to younger kids after all. Mayor Willie Brown last Wednesday ordered San Francisco Public Library officials to allow John O'Connor to read to preschool children to get them interested in books and stop them from watching television and video games. "I didn't expect this kind of attention. " John said, "It's just shocking." John has chosen his first book, "The King's Giraffe", and made up fliers inviting neighborhood children, aged from three to six, to the Presidio Branch every Wednesday afternoon. He planned to call himself the "Reading Wizard" and wear a special hat, fake glasses and a black coat. But his idea was refused - on the phone, in person and finally with a letter from Toni Bernardi, the chief of the library's children and youth services. Using terms like "age appropriate material" ,she wrote that only library workers are allowed to read to children. John then went to a member of the city board of supervisors , who advised him to write letters to the library officials. "Our libraries are supposed to turn kids on, not to turn them off." Brown said he enjoyed "the creative idea, the sense of civic duty and the caring for others that John clearly showed us."

Answer:
Who is the "Reading Wizard"?