In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Q: Background: Nurses leaving their jobs and the profession are an issue of international concern, with supplydemand gaps for nurses reported to be widening. There is a large body of existing literature, much of which is already in review form. In order to advance the usefulness of the literature for nurse and human resource managers, we undertook an overview (review of systematic reviews). The aim of the overview was to identify high quality evidence of the determinants and consequences of turnover in adult nursing. Methods: Reviews were identified which were published between 1990 and January 2015 in English using electronic databases (the Cochrane Database of Systematic Reviews, MEDLINE, EMBASE, Applied Social Sciences Index and Abstracts, CINAHL plus and SCOPUS) and forward searching. All stages of the review were conducted in parallel by two reviewers. Reviews were quality appraised using the Assessment of Multiple Systematic Reviews and their findings narratively synthesised. Results: Nine reviews were included. We found that the current evidence is incomplete and has a number of important limitations. However, a body of moderate quality review evidence does exist giving a picture of multiple determinants of turnover in adult nursing, with -at the individual level -nurse stress and dissatisfaction being important factors and -at the organisational level -managerial style and supervisory support factors holding most weight. The consequences of turnover are only described in economic terms, but are considered significant. In making a quality assessment of the review as well as considering the quality of the included primary studies and specificity in the outcomes they measure, the overview found that the evidence is not as definitive as previously presented from individual reviews. Further research is required, of rigorous research design, whether quantitative or qualitative, particularly against the outcome of actual turnover as opposed to intention to leave.

A: The determinants and consequences of adult nursing staff turnover: a systematic review of systematic reviews
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Q: Phenanthroquinolizidine alkaloids a b s t r a c t The stereoselective synthesis of epi-thieno analogues of the phenanthroquinolizidine bioactive alkaloids (À)-Cryptopleurine and (À)-(15R)-Hydroxycryptopleurine was achieved in five steps starting from easily available enantiopure (S)-2-aminoadipic acid used as chiral pool and nitrogen atom source. During these investigations, both p-cationic cyclization of chiral N-thienylmethyl-6-oxopipecolinic acids into pure (S)keto-lactams and theirs regioselective and diastereoselective reduction, considered as key steps of this sequence, were studied. Of particular interest, the FriedeleCrafts cyclization using (CF 3 CO) 2 O/BF 3 $Et 2 O show that near the expected keto-lactams, enamides and enamidones containing trifluoromethyl residue were isolated. A mechanism leading to the latter products with high synthetic potential was discussed.

A: Use of chiral-pool approach into epi-thieno analogues of the scarce bioactive phenanthroquinolizidine alkaloids
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Q: A facile one-pot two-enzyme chemoenzymatic approach has been established for gram (Neu4,5Ac 2 α3Lac, 1.33 g) and preparative-scale (Neu4,5Ac 2 α3LNnT) synthesis of monotreme milk oligosaccharides. Other O-acetyl-5-N-acetylneuraminic acid (Neu4,5Ac 2 )-or 4-O-acetyl-5-N-glycolylneuraminic acid (Neu4Ac5Gc)-containing α2-3-sialosides have also been synthesized in preparative scale. Used as an effective probe, Neu4,5Ac 2 α3GalβpNP was found to be a suitable substrate by human influenza A viruses but not bacterial sialidases. One-pot multienzyme (OPME) synthesis: Monotreme milk oligosaccharides and other sialosides containing a 4-O-acetyl-sialic acid were synthesized in gram (1.33 g for Neu4,5Ac 2 α3Lac) or preparative (10-56 mg) scales using a one-pot two-enzyme (OP2E) sialylation system containing a bacterial cytidine 5′-monophosphate (CMP)-sialic acid synthetase and Pasteurella multocida sialyltransferase 3 (PmST3). Neu4,5Ac 2 α3Galβ4GlcNAcβ3Galβ4GlcβProN 3 (34)-20 mg, yield 81%; white solid. 1 H NMR (800 MHz, D 2 O) δ 4.93 (m, 1H), 4.67 (d, J = 8.0 Hz, 1H), 4.54 (d, J = 8.0 Hz, 1H), 4.47 (d, J = 8.0 Hz, 1H), 4.41 (d, J = 8.0 Hz, 1H), 4.14 (d, J = 3.2 Hz, 1H), 4.11 (dd, J = 9.6 and 3.2 Hz, 1H), 4.07 (t, J = 10.4 Hz, 1H), 3.98-3.54 (m, 28H), 3.44 (t, J = 6.4 Yu et al.

A:
Effective one-pot multienzyme (OPME) synthesis of monotreme milk oligosaccharides and other sialosides containing a 4-O- acetyl sialic acid † HHS Public Access Author manuscript
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