Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: Notting hill is a small town west of London. Here lives shy William, a divorced man, who owns a little travel-book store. It was a Wednesday, when the poor shop keeper happened to meet Anna Scott ,a movie star who walked into his shop. They ran across each other in the street again. And they found themselves falling in love. But how could a poor man keep the love of a famous star? Their lives and their worlds were so different. Six months later, Anna was in London again for her new film. She came to William's thought ... Length :110 minutes Director:David Duning Cast:Julia Roberts(actress), Hugh Grant(actor)

A: What is the passage mainly discussing ?
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Q: In yeast, the macromolecular complex Set1/COMPASS is capable of methylating H3K4, a posttranslational modification associated with actively transcribed genes. There is only one Set1 in yeast; yet in mammalian cells there are multiple H3K4 methylases, including Set1A/B, forming human COMPASS complexes, and MLL1-4, forming human COMPASS-like complexes. We have shown that Wdr82, which associates with chromatin in a histone H2B ubiquitination-dependent manner, is a specific component of Set1 complexes but not that of MLL1-4 complexes. RNA interference-mediated knockdown of Wdr82 results in a reduction in the H3K4 trimethylation levels, although these cells still possess active MLL complexes. Comprehensive in vitro enzymatic studies with Set1 and MLL complexes demonstrated that the Set1 complex is a more robust H3K4 trimethylase in vitro than the MLL complexes. Given our in vivo and in vitro observations, it appears that the human Set1 complex plays a more widespread role in H3K4 trimethylation than do the MLL complexes in mammalian cells.

A: Which is the histone residue methylated by MLL1?
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Q: The Volme is a river in North Rhine-Westphalia, Germany, a left tributary of the Ruhr.

A:
Which river system contains Volme?
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