Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

[Q]: Context: The war had three phases. Initially it was a localized feud between supporters of Gebhard and those of the Catholic core of the Cathedral Chapter. With the election of Ernst of Bavaria as a competing archbishop, what had been a local conflict expanded in scale: Ernst's election guaranteed the military, diplomatic, and financial interest of the Wittelsbach family in the Electorate of Cologne's local affairs. After the deaths of Louis VI, Elector Palatine in 1583and William the Silent in 1584, the conflict shifted gears again, as the two evenly matched combatants sought outside assistance to break the stalemate. Finally, the intervention of Alexander Farnese, Duke of Parma, who had at his command the Spanish Army of Flanders, threw the balance of power in favor of the Catholic side. By 1588, Spanish forces had pushed Gebhard from the Electorate. In 1588 he took refuge in Strassburg, and the remaining Protestant strongholds of the Electorate fell to Parma's forces in 1589. 
 Question: After Louis VI, Elector Palatine, and Williant the Silent died, what set into motion the third phase of the war?
[A]: the intervention of alexander farnese


[Q]: Context: For travellers who want to experience some of the history and mystery of the ancient world, here is a list of cool destinations for your next holiday. Angkor Wat, Cambodia Built in the 12th century, Angkor Wat (meaning "capital monastery") was a temple in the ancient Khmer capital city of Angkor. It is Cambodia's best-known tourist attraction and is famed for its beautiful architecture and reliefs. You'll need at least three days to fully discover the delights of this magnificent site. Machu Picchu, Peru Machu Picchu was built high in the Andes Mountains of South America by the Inca in the 15th century. Although well preserved its exact purpose is unknown. It is famous throughout the world not only for its incredible design but also for the natural beauty that surrounds it. Give yourself a week to explore this magnificent site. Stonehenge, England The entire Stonehenge site was constructed over thousands of years. But why and how it was built remains a mystery. As the weather can be pretty bleak in winter and the crowds huge in summer, we suggest autumn should be the best time to visit these monster rocks. Pompeii, Italy When Mount Vesuvius erupted in 79 A.D., Pompeii was buried under many layers of ash, preserving the city exactly as it was when the volcano erupted. Because so many objects were preserved, scientists and visitors are able to better understand daily life in the ancient Roman Empire. 
 Question: Which location offers the most direct view into daily life in the ancient world?
[A]: pompeii.


[Q]: Context: Allele-specific gene silencing by RNA interference (RNAi) is therapeutically useful for specifically suppressing the expression of alleles associated with disease. To realize such allele-specific RNAi (ASPRNAi), the design and assessment of small interfering RNA (siRNA) duplexes conferring ASP-RNAi is vital, but is also difficult. Here, we show ASP-RNAi against the Swedish- and London-type amyloid precursor protein (APP) variants related to familial Alzheimer's disease using two reporter alleles encoding the Photinus and Renilla luciferase genes and carrying mutant and wild-type allelic sequences in their 3'-untranslated regions. We examined the effects of siRNA duplexes against the mutant alleles in allele-specific gene silencing and off-target silencing against the wild-type allele under heterozygous conditions, which were generated by cotransfecting the reporter alleles and siRNA duplexes into cultured human cells. Consistently, the siRNA duplexes determined to confer ASP-RNAi also inhibited the expression of the bona fide mutant APP and the production of either amyloid beta 40- or 42-peptide in Cos-7 cells expressing both the full-length Swedish- and wild-type APP alleles. The present data suggest that the system with reporter alleles may permit the preclinical assessment of siRNA duplexes conferring ASP-RNAi, and thus contribute to the design and selection of the most suitable of such siRNA duplexes. 
 Question: Which disease the London mutation involved in?
[A]:
alzheimer's disease