In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
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Question: Objectives. To critically appraise the efficacy and safety of Kangfuxinye enema combined with mesalamine for the ulcerative colitis (UC) patients and in addition to grade the quality of evidence by using the GRADE (grading of recommendations, assessment, development, and evaluation) approach. Methods. A literature search was performed in the Cochrane Library, MEDLINE, EMBASE, CBM, CNKI, VIP, and WanFang Databases. The search restrictions were patients with UC and RCTs. Studies including other treatments except Kangfuxinye with mesalamine were excluded. Results. Nineteen studies met the inclusion criteria. We found significant benefits of Kangfuxinye combined with mesalamine against mesalamine alone in improving response rate as well as reducing the recurrence rate and inflammation rate; meanwhile, the increase of the adverse events rate was not observed. Furthermore, the symptoms remission rate and the cure time were insignificant statistically. Additionally, GRADE results indicated that the quality of evidence regarding the above 6 outcomes was rated from very low to moderate quality. Conclusions. Although Kangfuxinye enema seems effective and safe for treating UC patients in this systematic review, Kangfuxinye enema combined with mesalamine was weakly recommended due to very low to moderate quality of available evidence by the GRADE approach.

Answer: Kangfuxinye Enema Combined with Mesalamine for Ulcerative Colitis: A Systematic Review and GRADE Approach


Question: The isolation of neutralizing monoclonal antibodies (nmAbs) against the Zika virus (ZIKV) might lead to novel preventative strategies for infections in at-risk individuals, primarily pregnant women. Here we describe the characterization of human mAbs from the plasmablasts of an acutely infected patient. One of the 18 mAbs had the unusual feature of binding to and neutralizing ZIKV despite not appearing to have been diversified by affinity maturation. This mAb neutralized ZIKV (Neut 50~2 μg/ml) but did not react with any of the four dengue virus serotypes. Except for the expected junctional diversity created by the joining of the V-(D)-J genes, there was no deviation from immunoglobulin germline genes. This is a rare example of a human mAb with neutralizing activity in the absence of detectable somatic hypermutation. Importantly, binding of this mAb to ZIKV was specifically inhibited by human plasma from ZIKV-exposed individuals, suggesting that it may be of value in a diagnostic setting.

Answer: A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus


Question: Molecular techniques have enabled major advances in the speed and sensitivity of the laboratory diagnosis of respiratory infections. Although the polymerase chain reaction is the most commonly used, there are several other methods available, which have applicability across the range of microbial pathogens. This review does not intend to be a comprehensive treatise on the rapid diagnosis of respiratory infections. There are several excellent textbooks that cover the field in detail 1,2 . It will, instead, focus on recent and future trends. Laboratory diagnosis is essential in the overwhelming majority of clinical conditions that require specific therapy. It is a misconception, for example, that streptococcal pharyngitis can be reliably differentiated on clinical grounds from viral pharyngitis in an individual patient. Probability estimates can be made (for instance common cold symptoms have an 80% negative predictive value for the diagnosis of bacterial pharyngitis), but confirmation is only after laboratory examination. Most diagnostic advances in the last decade have focused on detection technologies. It should not be forgotten, however, that sampling inadequacies are the prime reason for failure to identify aetiology. It is well recognised that, for most respiratory viruses, the delay in transport of the specimen to the laboratory is usually the major factor in both slowness of the process and a failure to make a diagnosis. There has been some success in applying near-patient testing. This has, in general, made the diagnosis of respiratory tract virus infection more reliable and speedier. It has had particular use in differentiating respiratory syncytial virus cases who might need admission from other causes of viral respiratory tract infection. Another important consideration is the type of specimen used. For lower respiratory tract bacterial infections, sputum is the gold standard specimen, but the quality of the specimen is key because oral and gastrointestinal secretions may contaminate it. Ideally, there should be fewer than 10 squamous cells and greater than 25 leukocytes in a low power (x100

Answer:
Recent advances in the rapid diagnosis of respiratory tract infection