In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Q: Paragraph: Autoregressive distributed lag (ARDL) approach Economic growth Error correction model US air travel and freight demand a b s t r a c t This paper examines the short-and long-run effects of economic growth and market shocks (e.g., 9/11 terrorist attacks, Iraq war, SARS epidemic, and 2008 financial crisis) on air passenger and freight services using an autoregressive distributed lag (ARDL) approach to cointegration. Results show that, in the longrun, both air passenger and freight services tend to increase with economic growth. In the short-run, however, only air passenger service is responsive to economic growth. Finally, only the 9/11 terrorist attacks and the SARS have detrimental effects on air passenger demand both in the short-and long-run, and in the long-run, respectively. However, these market shocks are found to have little impact on air freight demand. 
 Title: Dynamic relationship between air transport demand and economic growth in the United States: A new look

A: False
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Q: Paragraph: Objectives: Cow and calf performance in a semi-confined cow-calf production system was compared with total confinement using summer-born calves. Material and Methods: The experiment was conducted over 3 yr in eastern Nebraska (ENREC) and 2 yr in western Nebraska (PREC) in a randomized complete block design. Lactating, crossbred beef cows (n = 127 at ENREC; n = 56 at PREC) with summer-born calves were used from November to April. Treatments were (1) drylot feeding or (2) cornstalk grazing with supplementation. Dry-lot pairs were limit fed a crop residue and distillersbased diet to meet energy requirements of a lactating cow. A dried distillers grain-based pellet was supplemented to pairs on cornstalks at a rate of 2.4 kg of DM/pair daily. Dry-lot cow-calf pairs were limit fed 12.1 kg of DM/d throughout the trial. Results and Discussion: At ENREC, cows wintered on cornstalks lost BW and had a 0.46-unit decrease in BCS (P < 0.01), whereas cows in the dry-lot gained BW and had a 0.24-unit increase in BCS. At PREC, BCS increased by 0.03 units for cows wintered in the dry-lot and decreased by 0.26 units for cows wintered on cornstalks (P < 0.04). At both locations, calves fed in a dry-lot had greater ADG and BW per day of age compared with calves offered cornstalk grazing with supplementation (P ≤ 0.03). Implications and Applications: A partial budget suggests that lower winter production inputs compensate for reduced performance of calves when cow-calf pairs are wintered on cornstalks, making residue grazing a viable option in partial confinement systems. 
 Title: Performance of cows and summer-born calves and economics in semi-confined and confined beef systems

A: False
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Q: Paragraph: We investigated whether circulating osteopontin (OPN) could be used as a biomarker for cervical cancer. We employed a monoclonal antibody (mAb 659) specific for the unique and intact thrombin-sensitive site in OPN using an inhibition ELISA. We found significantly higher levels of OPN in 33 cervical cancer patients in both the plasma (mean +/-SD, 612 +/-106 ng/ mL) and serum (424 +/-121 ng/mL) compared to healthy subjects [409 +/-56 ng/mL, from 31 plasma samples (P < 0.0001), and 314 +/-98 ng/mL, from 32 serum samples (P = 0.0002), respectively]. Similar results were obtained when the plasma from a bigger group (147 individuals) of cervical cancer patients (560 +/-211 ng/mL) were compared with the same plasma samples of the healthy individuals (P = 0.0014). More significantly, the OPN level was highest in stage III-IV disease (614 +/-210 ng/mL, from 52 individuals; P = 0.0001) and least and nondiscriminatory in stage I (473 +/-110 ng/mL, from 40 individuals; P = 0.5318). No such discrimination was found when a mAb of a different specificity (mAb 446) was used in a similar inhibition ELISA to compare the two groups in the first study; a commercial capture ELISA also failed. The possibility that the target epitope recognized by the antibody probe in these assays was absent from the circulating OPN due to protein truncation was supported by gel fractionation of the OPN found in patients' plasma: 60-64 kDa fragments were found instead of the presumably full-length OPN (68 kDa) seen in healthy people. How these fragments are generated and what possible role they play in cancer biology remain interesting questions. . As a member of the family of small integrin-binding ligand, N-linked glycophosphoproteins (SIBLINGs), OPN is highly conserved among mammals [3] . Human OPN has 314 amino acids, including a unique and conserved thrombin-sensitive site. Cleavage of this site by thrombin, which normally occurs in the circulation, fragments the protein roughly into two equal halves, each with different biological activities. The amino-terminal half of the protein binds to a variety of cell surface integrins, such as αvβ1, αvβ3, αvβ5, αvβ6, and α8β1, through the arginine-glycine-aspartate ( 159 RGD 161 ) motif in the protein, and also with α4β1 and α9β1 integrins, through the thrombin-generated site ( 162 SVVYGLR 168 ). The carboxy-terminal half interacts with the CD44 cell surface splice variants, CD44v6 and CD44v3 [4, 5] . Through these various extracellular interactions, thrombin-activated OPN plays pivotal roles in diverse physiological processes, such as bone remodeling, inflammation, and wound healing [6], as well as in various pathologies, including autoimmunity [7-9] and tumor metastasis [10] or progression [11, 12] . Thrombin-activated OPN has also been reported to inhibit the apoptosis in, or promote the survival and proliferation of, cancer cells [3] . More recently, OPN was shown to exert an intracellular function which can affect diverse cellular processes such as tumor progression [13] and interferon-α production in dendritic cells [14] . Here, too, these functions require the OPN protein to be appropriately cleaved, not by thrombin, but by various caspases [15] or produced as appropriate truncates from RNA splice variants [16] [17] [18] . Extracellularly, various metalloproteinases (MMPs) also cleave OPN into various types of fragments which have various tumorigenic or biological activities [19, 20] . Overexpression of OPN in the form of mRNA transcripts or intracellular proteins was observed in tumor tissues derived from breast or lung cancer [21, 22] , ovarian cancer [23] , and cervical cancer [24] [25] [26] [27] . Significantly increased levels of circulating OPN were also reported for several types of cancer including cervical cancer [26] , prostate cancer [28] , and colorectal cancer [29] . However, there were conflicting reports regarding head and neck squamous cell carcinoma [30, 31] . In addition, different diagnostic kits were found to yield quite different results from one another for the same patient samples [32] . We were interested to use this non-invasive method to examine our cervical cancer patients. This type of cancer is very common in Hong Kong [24]; it is highly invasive and lethal since the disease can progress rapidly and asymptomatically from preclinical-lesion to overt cancer. We were disappointed with the results obtained initially using a commercial OPN detection kit, and consequently decided to devise our own detection assays. We herein describe the development of such an assay based on the use of a unique monoclonal antibody and an assay format that is used infrequently-inhibition ELISA. 
 Title: Osteopontin Fragments with Intact Thrombin-Sensitive Site Circulate in Cervical Cancer Patients

A:
False
****