In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: For a drug to permeate through the cornea, you must: 
 Options:  <1> Be totally ionized. <2> Present a very high polarity. <3> Join the lysozyme that is present in the tear fluid. <4> Present a certain lipophilicity and a minimum degree of water solubility. <5> Have weak acid character.
4

Question: Among the strategies of Emotional Regulation, which of the following would be an acceptance strategy within cognitive-behavioral therapies? 
 Options:  <1> Distraction. <2> Behavioral Activation <3> Exposure with Prevention of Response. <4> Emotional Expression Adjusted. <5> Emotional Inhibition.
4

Question: A 24-year-old woman, asymptomatic, with a history of father and sister with medullary thyroid carcinoma. Incidentally, an adrenal mass measuring 5 cm in diameter was discovered on computed tomography (CT). Which of the following options should be the next clinical decision? 
 Options:  <1> Given that it is asymptomatic, semestral control is recommended with serial CT scans of said lesion. <2> The search for a possible medullary carcinoma of the thyroid is a priority. <3> A pre-clinical Cushing syndrome should be suspected in the context of multiple endocrine neoplasia. <4> Puncture-aspiration of said lesion should be performed to elucidate the nature of said lesion. <5> Catecholamines should be determined in urine to rule out a pheochromocytoma.

5