TASK DEFINITION: Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
PROBLEM: Context: Looking to stop a three-game losing streak, the Raiders welcomed Derek Carr back after missing one week due to injury to face the Los Angeles Chargers. However, things did not start well for Carr as he threw an interception on his first pass of the day and the Chargers took over at the Raider 30-yard line. the defense held the Chargers to a field goal attempt from 48 yards out which was no good. The Raiders took advantage and moved the ball down the field before Carr hit Michael Crabtree from 23 yards out to give the Raiders a 7-0 lead. Neither team could muster much offense until midway through the second quarter when the Chargers moved 82 yards and scored on a Melvin Gordon touchdown run from one yard out to tie the game. With, 1:34 remaining in the half, the Raiders moved into Charger territory and connected on a Giorgio Tavecchio 44-yard field goal as time expired to give the Raiders a 10-7 lead at the half. On their first possession of the second half, the Raiders moved deep into Charger territory, but managed no points as Carr was intercepted for the second time in the game. The teams exchanged punts and fumbles as the game moved into the fourth quarter. The Chargers finally managed some offense as Philip Rivers hit Melvin Gordon for a six-yard touchdown pass to give the Charger at 14-10 lead. On their ensuing possession, Cordarrelle Patterson took the ball on an end around and scampered 47 yards for a touchdown. Giorgio Tavecchio would, however, miss the ensuing point after to leave the Raider lead at two points, 16-14. After exchanging punts, the Chargers took over with 4:09 remaining in the game. Rivers hit Hunter Henry for a 23-yard pass play to move the ball into Raider territory. with less than two minutes remaining, the Chargers moved the ball to the Raider 10 yard line and lined up for the game-winning field goal with three second left in the game. The field goal was good and the Raiders suffered their fourth straight loss, falling to 2-4 on the season. The four losses through six gamed equaled the number of losses they suffered the entire season the prior year. The Raider defense again struggled, giving up 343 total yards while the offense struggled as well, managing only 274 yards. Carr's two interceptions proved costly in his return. After the game, the team said his poor play was not due to his injury. 
 Question: Who is the Raiders field goal kicker?

SOLUTION: giorgio tavecchio

PROBLEM: Context: In the Caucasus region of Russia, nearly 50 out of every 100,000 people live to celebrate their 100th birthday, and many don't stop at 100! By comparison, in America only 3 people in 100,000 reach 100. But these Russian old people aren't alone. The Pakistanis, who live high in the Himalaya Mountains, and the Ecuadorans of the Andes Mountains seem to share the secret of long life, too. These people remain healthy in body and spirit despite the passage of time. While many older persons in industrial societies become weak and ill in their 60s and 70s, some Caucasians aged 100 to 140, work in the fields beside their great-great-grandchildren. Even the idea of aging is foreign to them. When asked "at what age does youth end?"most of these old people had no answer. Several replied, "Well, perhaps at age 80." What accounts for this ability to survive to such old age, and to survive so well?First of all, hard physical work is a way of life for all of these long-lived people. They begin their long days of physical labor as children and never seem to stop. For example, Mr . Rustam Mamedov is 142 years of age. His wife is 116 years old. They have been married for 90 years. Mr. Mamedov has no intention of retiring from his life as a farmer. "Why?What else would I do?"he asks. All these people get healthful rewards from the environment in which they work. They all come from mountainous regions. They live and work at elevations of 1,660 to 1,000 meters above sea level. The air has less oxygen and is pollution-free. This reduced-oxygen environment makes the heart and blood vessel system stronger. Another factor that may contribute to the good health of these people is their isolation. To a great extent, they are separated from the pressures and worries of industrial society. Inherited factors also play some role. Most of the longest-lived people had parents and grandparents who also reached very old ages. Good family genes may, therefore, be one factor in living longer. 
 Question: What is the main way of life for all of these long-lived people?

SOLUTION: hard physical work.

PROBLEM: Context: Autosomal-recessive hereditary spastic paraplegias (AR-HSP) consist of a genetically diverse group of neurodegenerative diseases characterised by pyramidal tracts dysfunction. The causative genes for many types of AR-HSP remain elusive. We tried to identify the gene mutation for AR-HSP with cerebellar ataxia and neuropathy. This study included two patients in a Japanese family with their parents who are first cousins. Neurological examination and gene analysis were conducted in the two patients and two normal family members. We undertook genome-wide linkage analysis employing single nucleotide polymorphism arrays using the two patients' DNAs and exome sequencing using one patient's sample. We detected a homozygous missense mutation (c.4189T>G, p.F1397V) in the lysosomal trafficking regulator (LYST) gene, which is described as the causative gene for Chediak-Higashi syndrome (CHS). CHS is a rare autosomal-recessive syndrome characterised by hypopigmentation, severe immune deficiency, a bleeding tendency and progressive neurological dysfunction. This mutation was co-segregated with the disease in the family and was located at well-conserved amino acid. This LYST mutation was not found in 200 Japanese control DNAs. Microscopic observation of peripheral blood in the two patients disclosed large peroxidase-positive granules in both patients' granulocytes, although they had no symptoms of immune deficiency or bleeding tendency. We diagnosed these patients as having adult CHS presenting spastic paraplegia with cerebellar ataxia and neuropathy. The clinical spectrum of CHS is broader than previously recognised. Adult CHS must be considered in the differential diagnosis of AR-HSP. 
 Question: Which mutated gene causes the ChediakHigashi Syndrome?

SOLUTION:
lysosomal trafficking regulator gene