In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

[EX Q]: Question: The denaturation of proteins: 
 Options:  <1> It is accompanied by the loss of their activity. <2> It supposes the rupture of peptide bonds. <3> It is always an irreversible process. <4> Alter its primary structure. <5> It is carried out by chaperone proteins.
[EX A]: 1

[EX Q]: Question: 78-year-old man with poorly controlled rheumatoid arthritis (RA). A history of 2 admissions for heart failure and atrial fibrillation in the last 6 months. In current treatment with infliximab, prednisone, furosemide, enalapril, carvedilol and acenocoumarol. Enter again for biventricular heart failure clinic. The ECG showed atrial fibrillation at 102 bpm and advanced left bundle branch block. An echocardiogram shows biatrial dilation, thickening of the left ventricular wall with ejection fraction of 45% and restrictive pattern. The analytical highlights: Hb 10 gr / dL, creatinine 2.1 mg / dL (FG 20 mL / min), CRP 124 mg / L, rheumatoid factor 240 U / L, BNP 980 ng / L, proteinuria 4.8 g / 24h. What is the most likely diagnosis? 
 Options:  <1> Cardio-renal syndrome type 2. <2> Amyloidosis AA. <3> Myocarditis of giant cells. <4> Toxicity due to infliximab. <5> Membranous glomerulonephritis associated with RA.
[EX A]: 2

[EX Q]: Question: Clay-colored stools are indicative of a problem of: 
 Options:  <1> Obstruction of the bile ducts. <2> Severe and prolonged diarrhea. <3> Gastrointestinal bleeding. <4> Long fasting. <5> Enteral feeding
[EX A]:
1