In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Background: One of the most commonly applied protectotype vaccination protocol against infectious bronchitis (IB) in broiler chickens in the EU is simultaneous or alternate use of Ma5 and 4/91 vaccine strains. After IB vaccination and infection, systemic and upper respiratory tract (URT), humoral and cell-mediated immunity (CMI), are stimulated. The level of this stimulation correlates with the level of protection against IB. Results: We've investigated the development of URT and systemic, cell-mediated and humoral immunity in commercial broiler chickens vaccinated with Ma5 and/or 4/91 strains at hatch day. We've demonstrated that the group vaccinated with Ma5 and 4/91 strain simultaneously developed the most desirable immunity which reflects the level of CD8 + T cells stimulation in spleen and Harderian gland, as well as the level of IgA and IgY in URT washings and serum and their cross-reactivity with 7 IBV strains. Conclusions: Although we did not demonstrate directly why Ma5 + 4/91 protocol is so efficient it seems that it combines the benefits of monovalent vaccination with either Ma5 or 4/91 and while Ma5 seems to stimulate CMI more efficiently, the 4/91 strain generates a wider spectrum of immune system cross-reactivity and higher URT IgA production.
Immunological aspects of the efficiency of protectotype vaccination strategy against chicken infectious bronchitis

Coronaviruses strains 229E and OC43 have been associated with various respiratory illnesses ranging from the self-resolving common cold to severe pneumonia. Although chronic underlying conditions are major determinants of severe respiratory virus infections, few data about coronavirus-related pneumonia in immunocompromised patients are available. Here we report 2 well-documented cases of pneumonia related to coronavirus 229E, each with a different clinical presentation. Diagnosis was made on the basis of viral culture and electron microscopy findings that exhibited typical crown-like particles and through amplification of the viral genome by reverse transcriptase-polymerase chain reaction. On the basis of this report, coronaviruses should be considered as potential causative microorganisms of pneumonia in immunocompromised patients.
Coronavirus 229E-Related Pneumonia in Immunocompromised Patients

journal homepage: www.elsevier.com/locate/u clim different scales have been widely studied by wind engineers and meteorologists. Concerns on the negative effects of urbanization on the environment recently make the topic increasingly important for urban planners and architects (Ng, 2009; Bottema, 1995) . Tall and compact building blocks seriously worsens the natural ventilation performance at the metropolitan areas, even though there is a large wind potential in the urban atmosphere boundary layer, such as Hong Kong which is a high-density coastal city. The natural ventilation is an important contributing factor to outdoor thermal comfort, especially in subtropical cities. Cheng et al. (2012) indicated that, taking the Physiologically Equivalent Temperature (PET) thermal comfort as a standard, wind speed decreasing from 1.0 to 0.3 m/s is equal to 1.9°C air temperature increase in the subtropical summer. Good planning and design which include the wind knowledge can mitigate negative effects of urbanization, particularly urban heat island intensity (Oke, 1987) . Furthermore, these planning and design make compact urban living environments more comfortable for residents and consequently aid in the restriction of uncontrolled urban spreading (European Environment Agency, 2006; Garreau, 1992) . This study aims to change the traditional experience-based design way toward a scientific windenvironment-sensitive architectural design, and ensures that the surrounding environment of the proposed buildings could be adequately considered. To mitigate the undesirable effects of the proposed buildings on the surrounding natural ventilation performance, four steps for knowledge-based decision making are significantly important in the design process. The first step is the analysis and simplification of local wind availability. Local wind availability is important for initial wind assessment at the urban scale. Furthermore, local wind data is necessary for the settings of the boundary condition for wind environment modeling at the city and building scales. The second step involves the modeling of the surrounding pedestrian airflow. The modeling results make detailed wind data available to all of wind engineers, urban planners, and architects for better understandings. The third step is the wind data collection. Both unbiased descriptions of the surrounding wind environment and critical windrelated design issue identification depend on an appropriate data collection process. Based on the robust application of the above three steps, the fourth step, the data interpretation can be confidently conducted. This step is critical in the decision-making process for building design implementation. A sufficient statistical analysis is necessary to summarize the collected wind data and correlate the modeling results with architectural design strategies. Then, knowledge-based decisions can be made by architects and urban planners. However, the methods used to follow the aforementioned steps in the research work, such as simplification of the input wind availability, analysis of the grid dependence, the influence of iterative convergence, data collection and analysis methods, are unsuitable for the real application because of the characteristics of the practical CFD application in the architectural design process. Compared with the modeling in the research work, the input conditions and proposed building morphologies are much more complicated in the real application. Requirements of architects in the data analysis are also very different with wind engineers and researchers. Thus, the current study focuses on the practical application of CFD simulation and aims to answer the questions that are often encountered by practicing wind consultants, architects, and planners: (1) how to set the appropriate boundary conditions, (2) how to verify the CFD simulation results in practical applications, and (3) how to collect and evaluate the simulation results to efficiently and accurately identify the important wind-related design issue for implementation. A procedural framework and methodologies for the practical application of CFD simulations in real architectural design process are provided in this study to make the CFD simulation more practical and dependable, as well as to make the results more helpful in architectural design. A case study in Hong Kong is conducted to illustrate how the proposed framework and methodologies can be used. The boundary condition is the local wind availability at the surrounding areas of the proposed new projects. Before the advent of modeling, wind data at the urban areas can be collected by using field measurement. However, given the limitations and difficulties in applying field measurement at urban areas (Oke, 2004 (Oke, , 2006 , the large scale modeling became a popular approach for the reproduction and

Practical application of CFD on environmentally sensitive architectural design at high density cities: A case study in Hong Kong