This task is about reading the given passage and construct a question about the information present in the passage. Construct a question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) its answer is a continuous text span from the paragraph. Avoid creating questions that (i) can be answered correctly without actually understanding the paragraph and (ii) uses same words or phrases given in the passage.

[EX Q]: Wound colonization refers to nonreplicating microorganisms within the wound, while in infected wounds, replicating organisms exist and tissue is injured. All multicellular organisms are colonized to some degree by extrinsic organisms, and the vast majority of these exist in either a mutualistic or commensal relationship with the host. An example of the former is the anaerobic bacteria species, which colonizes the mammalian colon, and an example of the latter is various species of staphylococcus that exist on human skin. Neither of these colonizations are considered infections. The difference between an infection and a colonization is often only a matter of circumstance. Non-pathogenic organisms can become pathogenic given specific conditions, and even the most virulent organism requires certain circumstances to cause a compromising infection. Some colonizing bacteria, such as Corynebacteria sp. and viridans streptococci, prevent the adhesion and colonization of pathogenic bacteria and thus have a symbiotic relationship with the host, preventing infection and speeding wound healing.
[EX A]: What does wound colonization refer to?

[EX Q]: The inhabitants of the British Isles have been drinking ale since the Bronze Age, but it was with the arrival of the Roman Empire in its shores in the 1st Century, and the construction of the Roman road networks that the first inns, called tabernae, in which travellers could obtain refreshment began to appear. After the departure of Roman authority in the 5th Century and the fall of the Romano-British kingdoms, the Anglo-Saxons established alehouses that grew out of domestic dwellings, the Anglo-Saxon alewife would put a green bush up on a pole to let people know her brew was ready. These alehouses quickly evolved into meeting houses for the folk to socially congregate, gossip and arrange mutual help within their communities. Herein lies the origin of the modern public house, or "Pub" as it is colloquially called in England. They rapidly spread across the Kingdom, becoming so commonplace that in 965 King Edgar decreed that there should be no more than one alehouse per village.
[EX A]: When did the inhabitants of the British Isles begin drinking ale?

[EX Q]: Ehrlich’s approach of systematically varying the chemical structure of synthetic compounds and measuring the effects of these changes on biological activity was pursued broadly by industrial scientists, including Bayer scientists Josef Klarer, Fritz Mietzsch, and Gerhard Domagk. This work, also based in the testing of compounds available from the German dye industry, led to the development of Prontosil, the first representative of the sulfonamide class of antibiotics. Compared to arsphenamine, the sulfonamides had a broader spectrum of activity and were far less toxic, rendering them useful for infections caused by pathogens such as streptococci. In 1939, Domagk received the Nobel Prize in Medicine for this discovery. Nonetheless, the dramatic decrease in deaths from infectious diseases that occurred prior to World War II was primarily the result of improved public health measures such as clean water and less crowded housing, and the impact of anti-infective drugs and vaccines was significant mainly after World War II.
[EX A]:
Who received the Nobel Prize in Medicine in 1939?