TASK DEFINITION: Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
PROBLEM: Context: Ana-Neda (Bulgarian and Serbian Cyrillic: -; fl. 1323-1324) was the Empress consort of Bulgaria briefly in 1323 - 1324 as the spouse of ''Despot of Vidin'' Michael Shishman who was elected as Emperor of Bulgaria in 1323. 
 Question: What was Ana-Neda's child's name?

SOLUTION: shishman

PROBLEM: Context: Chronic lymphocytic leukemia (CLL) cells depend on microenvironmental factors for proliferation and survival. In particular, the B-cell receptor (BCR) and nuclear factor- B (NF-B) pathways are activated in the lymph node (LN) microenvironment. Thus, model systems mimicking tumor-host interactions are important tools to study CLL biology and pathogenesis. We investigated whether the recently established NOD/scid/c(null) (NSG) mouse xenograft model can recapitulate the effects of the human microenvironment. We assessed, therefore, tumor characteristics previously defined in LN-resident CLL cells, including proliferation, and activation of the BCR and NF-B pathways. We found that the murine spleen (SP) microenvironment supported CLL cell proliferation and activation to a similar degree than the human LN, including induction of BCR and NF-B signaling in the xenografted cells. Next, we used this model to study ibrutinib, a Bruton's tyrosine kinase inhibitor in clinical development. Ibrutinib inhibited BCR and NF-B signaling induced by the microenvironment, decreased proliferation, induced apoptosis and reduced the tumor burden in vivo. Thus, our data demonstrate that the SP of xenografted NSG mice can, in part, recapitulate the role of the human LN for CLL cells. In addition, we show that ibrutinib effectively disrupts tumor-host interactions essential for CLL cell proliferation and survival in vivo. 
 Question: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?

SOLUTION: ibrutinib

PROBLEM: Context: The World's Largest Insect .This giant insect can be used as a toy. A child ties one end of a string to a stick and the other end around the "neck" of an insect. Holding the stick, the child lets the insect go. With a loud whirring sound, the insect takes off, pulling the string in a large curve over the child's head. The child laughs as the stick jumps around. The child is African, and the toy is the African Goliath beetle, the largest insect in the world. The Goliath is a true insect because it has six legs and a body that is divided into three parts. Like all beetles, it has two pairs of wings. The front pair are thick and stiff and protect the back pair, which are soft. It is these soft back wings that make the beetle fly forward. They also cause the loud whirring sound the beetle makes when it flies. To steer, the beetle twists and turns its legs the same way you steer a bike by turning its front wheel. African children often use the Goliath beetle as a toy. Although it is over 15 centimeters long, it is quite harmless. 
 Question: What do African children often use the Goliath beetle as?

SOLUTION:
a toy.