Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: Mowat-Wilson syndrome is a genetic condition characterized by a recognizable facial phenotype in addition to moderate to severe cognitive disability with severe speech impairment and variable multiple congenital anomalies. The anomalies may include Hirschsprung disease, heart defects, structural eye anomalies including microphthalmia, agenesis of the corpus callosum, and urogenital anomalies. Microcephaly, seizure disorder and constipation are common. All typical cases result from haploinsufficiency of the ZEB2 (also known as ZFHX1B or SIP-1) gene, with over 100 distinct mutations now described. Approximately 80% of patients have a nonsense or frameshift mutation detectable by sequencing, with the rest having gross deletions necessitating a dosage sensitive assay. Here we report on the results of comprehensive molecular testing for 27 patients testing positive for MWS. Twenty-one patients had a nonsense, frameshift, or splice site mutation identified by sequencing; 14 of which localized to exon 8 and 17 of which are novel. Six patients had deletions in the ZEB2 gene, including two novel partial gene deletions. This report, the first such analysis in North American patients, adds to the growing list of both novel pathogenic mutations associated with MWS, as well as other variants in the ZEB2 gene. In addition, we suggest an economical testing strategy.

A: Which gene is responsible for the development of the Mowat-Wilson syndrome?
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Q: BEIJING - Astronomers have defended against rumors that the terrible earthquake and the following tsunami in Japan were closely related to or even caused by the "supermoon" that will appear in the sky on Saturday. The word "supermoon" was introduced in a report by the British newspaper Daily Mail on March 9, which said amateur scientists were warning that such an astronomical phenomenon could disturb the Earth's climate patterns and may even cause earthquakes and volcanic activity. The moon will be 356,577 kilometers from the Earth on Saturday, the closest in 19 years, and the closest point in its oval orbit coincides with a full moon, the report said. However, Saturday's moon is not actually the closest to Earth in 19 years, Tang Haiming, an astronomer with Shanghai Astronomical Observatory under the Chinese Academy of Sciences, told Xinhua News Agency. A shorter distance of 356,570 km between the two bodies was reached in January 2005, and a distance of 356,566 km was seen in December 2008. Yet some people suggest that previous supermoons have occurred prior to extreme weather events. In 1974 the phenomenon was followed by Cyclone Tracy in Darwin, Australia, and in 2005 it occurred shortly before a deadly tsunami in Indonesia. Coincidentally, two fresh disasters happened in Asia right before Saturday's supermoon. The public's concern about their connection with the moon boomed after Japan's terrible earthquake and tsunami and an earthquake in Southwest China's Yunnan province that killed 25 people on March 10. But astronomers are trying to _ people that such rumors are merely unreasonable. "A supermoon could cause high tides but has no direct relation with natural disasters such as earthquakes," Liu Jie, a researcher with the China Earthquake Network Center, told China Daily on Tuesday. "We can't find any necessary connection between previous supermoons and earthquakes. And the quake in Japan occurred because the Earth's inner energy had accumulated to some extent, and it's not related to the moon. " he said. James Garvin, chief scientist at the Goddard Space Flight Center under NASA, said in an article on NASA's website that "the effects on Earth from a supermoon are minor.""The combination of the moon being at its closest to Earth in its orbit, and being in its 'full moon' configuration ( to the Earth and sun), should not affect the inner energy balance of the Earth, since there are lunar tides every day. " Zhu Jin, curator of the Beijing Planetarium, said"the moon moves around the earth in a certain path, so each orbit has a perigee - its closest approach, and an apogee - its furthest distance.""A lunar perigee occurs once a month and there are very small differences in distances between perigees,"he said."Those tiny differences are far from enough to cause earthquakes or eruption of a volcano,"he added.

A: What's the real reason for the quake in Japan?
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Q: Apollo 440 (alternately known as Apollo Four Forty or @440) are an English band formed in Liverpool in 1990.

A:
What city is the band Apollo 440 from?
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