Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
Chronic myeloid leukemia (CML) is arguably the best understood of all human malignancies. Its origins in the hematopoietic stem cell can be traced to a reciprocal translocation involving chromosomes 9 and 22, dubbed the Philadelphia chromosome, which is observed in essentially all patients. The resulting fusion gene, BCR/ABL, encodes an activated tyrosine kinase that can act alone to induce a CML-like syndrome in mouse models. These animal models have validated BCR/ABL as a target for the development of specific pharmaceutical inhibitors. The kinase inhibitor imatinib mesylate (Gleevec) is highly specific, effective, and minimally toxic, but may not effect cures as a single agent, particularly in patients with accelerated and blast-phase disease. Resistance to imatinib can confound therapy. Surprisingly, a high percentage of resistant cases manifest intact or augmented BCR/ABL signaling, suggesting that this oncoprotein, or signaling pathways emanating from it, remain viable targets. Combination chemotherapy is under active investigation, and among the most compelling strategies is dual treatment with agents that both target BCR/ABL signal transduction. BCR/ABL activates Ras, and compounds designed to antagonize Ras function called farnesyl transferase inhibitors (FTIs) have shown potent activity in vitro and in animal models of BCR/ABL-induced leukemia. Initial clinical trials in patients with refractory acute myeloid leukemia and CML in blast crisis have shown significant activity, suggesting that trials combining imatinib and FTIs are warranted.

Ex Output:
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Ex Input:
Elis Stromgren's son was the astronomer Bengt Stromgren, who succeeded his father in Copenhagen in 1940.

Ex Output:
Who is the offspring of Elis Strömgren?


Ex Input:
As was discussed in previous concepts, both infectious and noninfectious diseases of the reproductive system can be very serious. But there are ways to keep your reproductive system healthy. What can you do to keep your reproductive system healthy? You can start by making the right choices for overall good health. To be as healthy as you can be, you should: Eat a balanced diet that is high in fiber and low in fat. Drink plenty of water. Get regular exercise. Maintain a healthy weight. Get enough sleep. Avoid using tobacco, alcohol, or other drugs. Manage stress in healthy ways. Keeping your genitals clean is also very important. A daily shower or bath is all that it takes. Females do not need to use special feminine hygiene products. In fact, using them may do more harm than good because they can irritate the vagina or other reproductive structures. You should also avoid other behaviors that can put you at risk. Do not get into contact with another persons blood or other body fluids. For example, never get a tattoo or piercing unless you are sure that the needles have not been used before. This is one of the most important ways to prevent an STI. Of course, the only way to be fully protected against STIs is to refrain from sexual activity. If you are a boy, you should always wear a protective cup when you play contact sports. Contact sports include football, boxing, and hockey. Wearing a cup will help protect the testes from injury. You should also do a monthly self-exam to check for cancer of the testes. If you are a girl and use tampons, be sure to change them every four to six hours. Leaving tampons in for too long can put you at risk of toxic shock syndrome. This is a serious condition. Signs and symptoms of toxic shock syndrome develop suddenly, and the disease can be fatal. The disease involves fever, shock, and problems with the function of several body organs. Girls should also get in the habit of doing a monthly self-exam to check for breast cancer. Although breast cancer is rare in teens, its a good idea to start doing the exam when you are young. It will help you get to know what is normal for you.

Ex Output:

girls should perform monthly self-exams to check for