Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
--------
Question: This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring.

Answer: adverse drug event


Question: DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy.

Answer: adverse drug event


Question: Under the suspicion of amiodarone-induced acute pancreatitis, amiodarone was substituted by propafenone.

Answer:
adverse drug event