In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Example Input: Paragraph: The major biochemical and thermodynamic features of nucelocapsid protein of SARS coronavirus (SARS _ NP) were characterized by use of non-denatured gel electrophoresis, size-exclusion chromatographic and surface plasmon resonance (SPR) techniques. The results showed that SARS _ NP existed in vitro as oligomer, more probably dimer, as the basic functional unit. This protein shows its maximum conformational stability near pH 9.0, and it seems that its oligomer dissociation and protein unfolding occur simultaneously. Thermal-induced unfolding for SARS _ NP was totally irreversible. Both the thermal and chemical denaturant-induced denaturation analyses showed that oligomeric SARS _ NP unfolds and refolds through a two-state model, and the electrostatic interactions among the charge groups of SARS _ NP made a significant contribution to its conformational stability. D Abbreviations: SARS _ CoV, severe acute respiratory syndrome coronavirus; SARS _ NP, nucleocapsid protein of SARS; SPR, surface plasmon resonance; GuHCl, guanidine hydrochloride; CD, circular dichroism; T m and C m , transition midpoints of thermal and chemical denaturations; IPTG, isopropyl-h-d-thiogalasctopyranoside; N and U, native and unfolded states. 
 Title: In vitro biochemical and thermodynamic characterization of nucleocapsid protein of SARS
Example Output: False

Example Input: Paragraph: Dendritic cells are potent antigen-capture and -presenting cells that play a key role in the initiation and regulation of the adaptive immune response. This process of immune homeostasis, as maintained by dendritic cells, is susceptible to dysregulation by certain pathogens during chronic infections. Such dysregulation may lead to disease perpetuation with potentially severe systemic consequences. Here we discuss in detail how intracellular pathogens exploit dendritic cells and evade degradation by altering or evading autophagy. This novel mechanism explains in part the chronic, persistent nature observed in several immuno-inflammatory diseases, including periodontal disease. Also, here we propose a hypothetical model on the plausible role of autophagy in the context of periodontal disease. Promotion of autophagy may open new therapeutic strategies in the search for a "cure" for periodontal disease in humans. 
 Title: Dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease
Example Output: True

Example Input: Paragraph: Porcine deltacoronavirus (δ-CoV) is the object of extensive research in several countries including the United States. In contrast, the epidemiology of δ-CoVs in wild birds in the US is largely unknown. Our aim was to comparatively assess the prevalence of δand γ-CoVs in wild migratory terrestrial and aquatic birds in Arkansas, Illinois, Indiana, Maryland, Mississippi, Missouri, Ohio, Tennessee and Wisconsin. A total of 1236 cloacal/fecal swabs collected during the period 2015-2018 were tested for γand δ-CoVs using genus-specific reverse transcription-PCR assays. A total of 61 (4.99%) samples were γ-CoV positive, with up to 29 positive samples per state. In contrast, only 14 samples were positive for δ-CoV (1.14%) with only 1-4 originating from the same state. Thus, unlike previous reports from Asia, γ-CoVs are more prevalent than δ-CoVs in the US, suggesting that δ-CoVs may spread in birds with lower efficiency. This may indicate δ-CoV emerging status and incomplete adaptation to new host species limiting its spread. Phylogenetic analysis of the partial N gene revealed that the newly identified δ-CoV strains were most closely related to the HKU20 (wigeon) strain. Further studies are necessary to investigate the role of aquatic bird δ-CoVs in the epidemiology of δ-CoVs in swine and terrestrial birds. Viruses 2019, 11, 897 2 of 11 and mammals including pigs [4] . Porcine deltacoronavirus (PDCoV) emerged in the US in 2014 as a new enteropathogenic CoV causing diarrhea, vomiting, and mortality in neonatal piglets, resulting in economic losses to the swine industry [4, 5] . Its origin is unknown, but it is hypothesized that it may have spilled over from an avian host. δ-CoV and γ-CoV are co-circulating in wild avian species, but their epidemiology (prevalence and diversity) differ [6] [7] [8] [9] [10] [11] [12] [13] . In a screening study of 918 wild Australian birds, 141 of them tested positive for CoVs. After sequencing, δ-CoV was detected in pacific black ducks, curlew sandpiper, red-necked stints, ruddy turnstones, and pied herons [6] . However, γ-CoV (80% of sequenced samples) was identified more frequently than δ-CoV (20% of sequenced samples) [6] . γ-CoV was also detected in quails and pheasants in Italy [7] . RNA-dependent RNA polymerase (RdRp) analyses found that quail were also infected with δ-CoV [7]. Wild birds harbor genetically diverse δ-CoV with some of them potentially transmittable to pigs [8] . A previous report from Brazil showed that δ-CoVs were detected in two species of wild terrestrial birds, purple-breasted-parrot and plain parakeet. These avian CoVs were monophyletically related to CoVs from Sparrow (SPaCoV HKU19) and swine (PorCoV HKU15), which were also found to be δ-CoV. This information supports the hypothesis that δ-CoV can cross inter-species barriers, with the potential to transmit from birds to swine [8] . Previous studies of CoVs in Hong Kong reported three novel CoVs in bulbuls (BuCoV HKU11), thrushes (ThCoV HKU12) and munias (MuCoV HKU13), which were hypothesized to belong to the novel genus δ-CoV [9]. These three novel δ-CoVs clustered with a δ-CoV detected in Asian leopard cats [10]; however, further studies are necessary to understand interspecies transmission from birds [9]. In a surveillance study in Hong Kong and Cambodia, δ-CoVs were found in different wild aquatic birds: gray herons, pond herons, great cormorants, black-faced spoonbills, and several duck species [11] . δ-CoVs do not cause severe illness in birds, leading to their endemic nature in the avian population [11] . In a screening study for δ-CoVs in China, none were found in Asian leopard cats, bats, domestic cats, cattle, chickens, dogs, humans, monkeys, and rodents [12] . The investigators discovered seven novel δ-CoVs in pigs and wild birds (white-eye, sparrow, magpie robin, night heron, wigeon, and common moorhen) [12] . Genome sequencing and comparative genome analysis showed that avian and swine δ-CoVs had similar genome characteristics and structures [12] . Similarly, a recent study in the US described a novel sparrow δ-CoV that clustered together with PDCoV [13] and other terrestrial, but aquatic bird δ-CoVs. In Brazil, screening revealed the presence of CoVs in vinaceous-breasted amazon and plain parakeet, that were closely related to δ-CoVs from birds (SpaCoV HKU17) and swine (PorCoV). This emphasizes the increased risk for direct interspecies transmission and that in contrast to waterfowl, terrestrial birds may act as intermediate hosts and are commonly found in the sites of bird-swine co-mingling [8]. In Finland, two different avian δ-CoV strains from lesser black-backed gull and black-headed gull were detected which shared 83% and 85% nucleotide identity with avian and mammalian δ-CoVs, respectively [14] . In summary, recently identified δ-CoVs are emerging globally that possess high genetic and antigenic plasticity. Porcine δ-CoV is being studied extensively in the US and elsewhere [4, 5] . In contrast, the diversity and epidemiology of δ-CoVs in wild birds in the US are largely unknown. The association of porcine δ-CoV with enteric disease in pigs and its continuous spread underscore an urgent need to further investigate the mechanisms of its persistence and spread. Extensive epidemiological studies are needed to evaluate δ-CoV prevalence in avian species, swine farms, pig-bird comingling sites and high pig-traffic sites such as abattoirs, assembly yards and truck washes. In this study, we investigated the prevalence of δand γ-CoVs in wild migratory terrestrial and aquatic birds in Arkansas, Illinois, Indiana, Maryland, Mississippi, Missouri, Ohio, Tennessee, and Wisconsin. Author Contributions: Conceptualization, A.N.V.; methodology, F.C.P., L.M., B.J.F. and D.M.; software, F.C.P., A.N.V., L.M and D.M.; validation, A.N.V. and F.C.P.; formal analysis, A.N.V.; F.C.P.; investigation, F.C.P. and A.N.V.; resources, A.S.B. and A.N.V.; data curation, F.C.P. and A.N.V.; writing-original draft preparation, F.C.P.; writing-review and editing, F.C.P., A.N.V., L.J.S., A.S.B. and B.J.F.; visualization, A.N.V and F.C.P.; supervision, A.N.V. and L.J.S.; project administration, A.N.V. and L.J.S.; funding acquisition, A.N.V. and L.J.S. 
 Title: Epidemiology of Deltacoronaviruses (δ-CoV) and Gammacoronaviruses (γ-CoV) in Wild Birds in the United States
Example Output:
False