instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Brian Cohen is born in a stable next door to the one in which Jesus is born, which initially confuses the three wise men who come to praise the future King of the Jews. Brian grows up an idealistic young man who resents the continuing Roman occupation of Judea. While attending Jesus' Sermon on the Mount, Brian becomes infatuated with an attractive young rebel, Judith. His desire for her and hatred for the Romans lead him to join the "People's Front of Judea", one of many fractious and bickering independence movements, who spend more time fighting each other than the Romans. After several misadventures, and escaping from Pontius Pilate, Brian winds up in a line-up of would-be mystics and prophets who harangue the passing crowd in a plaza. Forced to come up with something plausible in order to blend in and keep the guards off his back, Brian repeats some of what he had heard Jesus say, and quickly attracts a small but intrigued audience. Once the guards have left, Brian tries to put the episode behind him, but he has unintentionally inspired a movement. He grows frantic when he finds that some people have started to follow him around, with even the slightest unusual occurrence being hailed as a miracle. Each of their responses ever growing in fervor and intensity making it harder and harder for him to get away from them. Yet because of the mob's excitement, they end up leaving Brian alone. After which he sees Judith is one who didn't leave, and they then spend the night together. In the morning, Brian, completely naked, opens the curtains to discover an enormous crowd outside his mother's house who proclaim him to be the Messiah. Brian's mother protests, "He's not the Messiah, he's a very naughty boy."; and, "There's no Messiah in here. There's a mess all right, but no Messiah." Yet all of her attempts at dispersing the crowd are rebuffed. Furthermore, once Brian addresses them, he also finds that he is unable to change their minds. His followers are completely committed to their beliefs in and of Brian's divinity. They immediately seize upon everything he says and does as points of doctrine. The hapless Brian finds no solace as people have even mobbed his mother's house. They fling their afflicted bodies at him demanding miracle cures and divine secrets. After sneaking out the back, Brian is then finally captured and scheduled to be crucified. Meanwhile, a huge crowd has assembled outside the palace. Pilate (together with the visiting Biggus Dickus) tries to quell the feeling of revolution by granting them the choice of one person to be pardoned. The crowd, however, shouts out names containing the letter "r", mocking Pilate's rhotacistic speech impediment. Eventually, Judith appears in the crowd and calls for the release of Brian, which the crowd echoes since the name also contains an "r". Pilate agrees to "welease Bwian". His order is eventually relayed to the guards, but in a scene that parodies the climax of the film Spartacus, various crucified people all claim to be "Brian of Nazareth" and the wrong man is released. Various other opportunities for a reprieve for Brian are denied as, one by one, his "allies" (including Judith and his mother) step forward to explain why they are leaving the "noble freedom fighter" hanging in the hot sun. Hope is renewed when a crack suicide squad from the "Judean People's Front" (not to be confused with the People's Front of Judea) come charging towards the Romans, but rather than fighting to release Brian or the other prisoners, they commit mass suicide as a political protest. Condemned to a long and painful death, Brian finds his spirits lifted by his fellow sufferers, who break into song with "Always Look on the Bright Side of Life."[6]
answer:
Where is Brian Cohen born ?


question:
Spleen tyrosine kinase (Syk) is a cytoplasmic tyrosine kinase involved in signalling in many of the cells that drive immune inflammation. The development of small molecules that inhibit Syk kinase may change the way we treat disorders such as rheumatoid arthritis (RA), as well as a range of other inflammatory diseases. Fostamatinib (R-788) is an orally bioavailable small molecule. It is the prodrug of R406, which is a potent Syk inhibitor. Fostamatinib was developed because it has more favourable physiochemical properties. It is rapidly converted to R406 by intestinal enterocytes. It has been evaluated in experimental models of RA, such as collagen-induced arthritis. In these models, fostamatinib suppressed clinical arthritis, bone erosions, pannus formation and synovitis. A phase II programme with fostamatinib has largely been completed. Three key trials have been published, lasting 12-26 weeks and each enrolling 189-457 patients (875 in total). All these trials involved placebo therapy and patients continued to receive methotrexate in addition to active treatment with fostamatinib. The first dose-ranging trial evaluated three treatment doses in RA patients who had not fully responded to methotrexate therapy. The second trial compared two treatment doses in patients who had not responded to methotrexate therapy. The third trial compared a single treatment dose with placebo in patients who had not responded to biological therapy. The primary outcome measure was the number of patients achieving American College of Rheumatology (ACR) 20% (ACR20) responses. Placebo ACR20 response rates in all three trials were similar (35-38%). All three trials involved one treatment arm receiving fostamatinib 100 mg twice daily; ACR20 responses with this active treatment ranged from 38% to 67%. A meta-analysis of ACR responses in these trials, using responses to the highest dose in each trial for comparisons with placebo therapy in a random effects model, showed a borderline benefit with ACR20 responses. There were more significant differences with ACR50 and ACR70 responses. The reason that this meta-analysis was not more strongly positive is that the third trial, which evaluated patients who had failed to respond to biological treatments, gave negative results. Individual ACR response components, such as changes in swollen joint counts, showed significant differences in the first two trials, but there were no definite treatment benefits in the third trial. Overall, the differences were significant in a meta-analysis of all three trials. The most important adverse reactions were diarrhoea, neutropenia and raised ALT levels, which all showed significant excesses with active treatment compared with placebo. Too few patients have been studied for a definitive safety profile to be known. Overall, the results of the phase II trials were sufficiently encouraging for a phase III programme to be initiated. It will be some years before their definitive results are available.
answer:
Which enzyme is inhibited by a drug fostamatinib?


question:
A few years ago, Paul Gerner began to gather a group of architects in Las Vegas to ask them what it would take to design a public school that used 50 percent less energy, cost much less to build and obviously improved student learning. "I think half of them fell off their chairs," Gerner says. Gerner manages school facilities for Clark County, Nevada, a district roughly the size of Massachusetts. By 2018, 143,000 additional students will enter the already crowded public-education system. Gerner needs 73 new schools to house them. Four architecture teams have nearly finished designing primary school prototypes ; they plan to construct their schools starting in 2009. The district will then assess how well the schools perform, and three winners will copy those designs in 50 to 70 new buildings. Green schools are appearing all over, but in Clark County, which stands out for its vastness, such aggressive targets are difficult because design requirements like more natural light for students go against the realities of a desert climate. "One of the biggest challenges is getting the right site orientation ," Mark. McGinty, a director at SH Architecture, says. His firm recently completed a high school in Las Vegas. "You have the same building, same set of windows, but if its orientation is incorrect and it faces the sun, it will be really expensive to cool." Surprisingly, the man responsible for one of re most progressive green-design competitions has doubts about ideas of eco-friendly buildings. "I don't believe in the new green religion," Gerner says. "Some of the building technologies that you get are impractical. I'm interested in those that work." But he wouldn't mind if some green features inspire students. He says he hopes to set up green energy systems that allow them to learn about the process of harvesting wind and solar power. "You never know what's going to start the interest of a child to study math and science," he says.
answer:

What makes it difficult to build green schools in Clark County?