Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Input: Consider Input: Context: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. Despite significant progresses in the last decades, the origin of this cancer remains unclear and no efficient therapy exists. PDAC does not arise de novo: three remarkable different types of pancreatic lesions can evolve towards pancreatic cancer. These precursor lesions include: Pancreatic intraepithelial neoplasia (PanIN) that are microscopic lesions of the pancreas, Intraductal Papillary Mucinous Neoplasms (IPMN) and Mucinous Cystic Neoplasms (MCN) that are both macroscopic lesions. However, the cellular origin of these lesions is still a matter of debate. Classically, neoplasm initiation or progression is driven by several genetic and epigenetic alterations. The aim of this review is to assemble the current information on genetic mutations and epigenetic disorders that affect genes during pancreatic carcinogenesis. We will further discuss the interest of the genetic and epigenetic alterations for the diagnosis and prognosis of PDAC. Large genetic alterations (chromosomal deletion/amplification) and single point mutations are well described for carcinogenesis inducers. Mutations classically occur within key regions of the genome. Consequences are various and include activation of mitogenic pathways or silencing of apoptotic processes. Alterations of K-RAS, P16 and DPC4 genes are frequently observed in PDAC samples and have been described to arise gradually during carcinogenesis. DNA methylation is an epigenetic process involved in imprinting and X chromosome inactivation. Alteration of DNA methylation patterns leads to deregulation of gene expression, in the absence of mutation. Both genetic and epigenetic events influence genes and non-coding RNA expression, with dramatic effects on proliferation, survival and invasion. Besides improvement in our fundamental understanding of PDAC development, highlighting the molecular alterations that occur in pancreatic carcinogenesis could provide new clinical tools for early diagnosis of PDAC and the molecular basis for the development of new effective therapies. 
 Question: Which is the molecular mechanism underlying K-ras alterations in carcinomas?

Output: point mutations


Input: Consider Input: Context: Earth formed at the same time as the other planets. The history of Earth is part of the history of the Solar System. Earth came together (accreted) from the cloud of dust and gas known as the solar nebula nearly 4.6 billion years ago, the same time the Sun and the rest of the solar system formed. Gravity caused small bodies of rock and metal orbiting the proto-Sun to smash together to create larger bodies. Over time, the planetoids got larger and larger until they became planets. When Earth first came together it was really hot, hot enough to melt the metal elements that it contained. Earth was so hot for three reasons: Gravitational contraction: As small bodies of rock and metal accreted, the planet grew larger and more massive. Gravity within such an enormous body squeezes the material in its interior so hard that the pressure swells. As Earths internal pressure grew, its temperature also rose. Radioactive decay: Radioactive decay releases heat, and early in the planets history there were many ra- dioactive elements with short half lives. These elements long ago decayed into stable materials, but they were responsible for the release of enormous amounts of heat in the beginning. Bombardment: Ancient impact craters found on the Moon and inner planets indicate that asteroid impacts were common in the early solar system. Earth was struck so much in its first 500 million years that the heat was intense. Very few large objects have struck the planet in the past many hundreds of millions of year. When Earth was entirely molten, gravity drew denser elements to the center and lighter elements rose to the surface. The separation of Earth into layers based on density is known as differentiation. The densest material moved to the center to create the planets dense metallic core. Materials that are intermediate in density became part of the mantle (Figure 1.1). Lighter materials accumulated at the surface of the mantle to become the earliest crust. The first crust was probably basaltic, like the oceanic crust is today. Intense heat from the early core drove rapid and vigorous mantle convection so that crust quickly recycled into the mantle. The recycling of basaltic crust was so effective that no remnants of it are found today. There is not much material to let us know about the earliest days of our planet Earth. What there is comes from three sources: (1) zircon crystals, the oldest materials found on Earth, which show that the age of the earliest crust formed at least 4.4 billion years ago; (2) meteorites that date from the beginning of the solar system, to nearly 4.6 billion years ago (Figure 1.2); and (3) lunar rocks, which represent the early days of the Earth-Moon system as far back as 4.5 billion years ago. 
 Question: which is not a reason why earth was molten in its early days?

Output: the sun


Input: Consider Input: Context: The current President of Krakow, re-elected for his fourth term in 2014, is Jacek Majchrowski. 
 Question: Who was in charge of Krakow?


Output: jacek majchrowski