instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: The circumsporozoite protein (CS protein) on the malaria parasites in mosquitoes plays an important role in sporogony in mosquitoes. The RTS,S/AS01 malaria vaccine candidate, which has shown significant efficacy against clinical malaria in a large Phase 3 trial, targets the Plasmodium falciparum CS protein, but the ability of serum from vaccinated individuals to inhibit sporogony in mosquitoes has not been evaluated. Previously a double-blind, randomized trial of RTS,S/AS01 vaccine, as compared with rabies vaccine, in five- to 17-month old children in Tanzania was conducted. In this study, polyclonal human antibodies were purified from the pools of sera taken one month after the third vaccination. IgGs were purified from four pools of sera from 25 RTS,S/AS01 vaccinated children each, and two pools of sera from 25 children vaccinated with rabies vaccine each. The ability of antibodies to inhibit P. falciparum oocyst formation and/or sporogony in the mosquito host was evaluated by a standard membrane-feeding assay. The test antibodies were fed on day 0 (at the same time as the gametocyte feed), or on days 3 or 6 (serial-feed experiments). The oocyst and sporozoite counts were performed on days 8 and 16, respectively. In addition, two human anti-CS monoclonal antibodies (mAb) and a control mAb were also evaluated. Polyclonal anti-CS IgG preparations from RTS,S-vaccinated children tested at concentrations of 149-210 ELISA units (EU)/ml did not show significant inhibition in oocyst and sporozoite formation when the antibodies were fed with gametocytes at the same time, or later (serial-feed experiments). Similarly, anti-CS mAbs tested at 6,421 or 7,122 EU/ml did not show reduction in oocyst and sporozoite formation. This study does not support the concept that anti-CS antibodies induced by the RTS,S/AS01 vaccines in humans noticeably reduce malaria transmission by blocking P. falciparum sporozoite development or salivary gland invasion in mosquitoes when taken up during feeding. 
 Question: RTS S AS01 vaccine was developed to prevent which disease?
answer:
malaria


question:
Context: The photo above represents water in three common states of matter. States of matter are different phases in which any given type of matter can exist. There are actually four well-known states of matter: solid, liquid, gas, and plasma. Plasma isnt represented in the iceberg photo, but the other three states of matter are. The iceberg itself consists of water in the solid state, and the lake consists of water in the liquid state. Q: Where is water in the gaseous state in the above photo? A: You cant see the gaseous water, but its there. It exists as water vapor in the air. Q: Water is one of the few substances that commonly exist on Earth in more than one state. Many other substances typically exist only in the solid, liquid, or gaseous state. Can you think of examples of matter that usually exists in just one of these three states? A: Just look around you and you will see many examples of matter that usually exists in the solid state. They include soil, rock, wood, metal, glass, and plastic. Examples of matter that usually exist in the liquid state include cooking oil, gasoline, and mercury, which is the only metal that commonly exists as a liquid. Examples of matter that usually exists in the gaseous state include oxygen and nitrogen, which are the chief gases in Earths atmosphere. A given kind of matter has the same chemical makeup and the same chemical properties regardless of its state. Thats because state of matter is a physical property. As a result, when matter changes state, it doesnt become a different kind of substance. For example, water is still water whether it exists as ice, liquid water, or water vapor. The most common states of matter on Earth are solids, liquids, and gases. How do these states of matter differ? Their properties are contrasted in the Figure 1.1. Click image to the left or use the URL below. URL: Properties of matter in different states. Q: The Figure 1.2 shows that a liquid takes the shape of its container. How could you demonstrate this? A: You could put the same volume of liquid in containers with different shapes. This is illustrated below with a beaker (left) and a graduated cylinder (right). The shape of the liquid in the beaker is short and wide like the beaker, while the shape of the liquid in the graduated cylinder is tall and narrow like that container, but each container holds the same volume of liquid. Q: How could you show that a gas spreads out to take the volume as well as the shape of its container? A: You could pump air into a bicycle tire. The tire would become firm all over as air molecules spread out to take the shape of the tire and also to occupy the entire volume of the tire. 
 Question: the only state in which matter has a fixed shape is
answer:
solid.


question:
Context: Shigeri Sada (born 13 December 1954) is a former Japanese football player.He is the younger brother of singer Masashi Sada. 
 Question: Who was the brother of Shigeri Sada?
answer:

masashi sada