In this task, you are given a question and a context passage. You have to answer the question based on the given passage.

Input: Consider Input: What needs to decrease before pituitary growth hormone can increase in the blood?, Context: In addition to the negative consequences of sleep deprivation, sleep and the intertwined circadian system have been shown to have strong regulatory effects on immunological functions affecting both the innate and the adaptive immunity. First, during the early slow-wave-sleep stage, a sudden drop in blood levels of cortisol, epinephrine, and norepinephrine induce increased blood levels of the hormones leptin, pituitary growth hormone, and prolactin. These signals induce a pro-inflammatory state through the production of the pro-inflammatory cytokines interleukin-1, interleukin-12, TNF-alpha and IFN-gamma. These cytokines then stimulate immune functions such as immune cells activation, proliferation, and differentiation. It is during this time that undifferentiated, or less differentiated, like naïve and central memory T cells, peak (i.e. during a time of a slowly evolving adaptive immune response). In addition to these effects, the milieu of hormones produced at this time (leptin, pituitary growth hormone, and prolactin) support the interactions between APCs and T-cells, a shift of the Th1/Th2 cytokine balance towards one that supports Th1, an increase in overall Th cell proliferation, and naïve T cell migration to lymph nodes. This milieu is also thought to support the formation of long-lasting immune memory through the initiation of Th1 immune responses.

Output: cortisol, epinephrine, and norepinephrine


Input: Consider Input: Which time had higher temperatures in England, the Medieval Warm Period or 2007?, Context: The third assessment report (TAR) prominently featured a graph labeled "Millennial Northern Hemisphere temperature reconstruction" based on a 1999 paper by Michael E. Mann, Raymond S. Bradley and Malcolm K. Hughes (MBH99), which has been referred to as the "hockey stick graph". This graph extended the similar graph in Figure 3.20 from the IPCC Second Assessment Report of 1995, and differed from a schematic in the first assessment report that lacked temperature units, but appeared to depict larger global temperature variations over the past 1000 years, and higher temperatures during the Medieval Warm Period than the mid 20th century. The schematic was not an actual plot of data, and was based on a diagram of temperatures in central England, with temperatures increased on the basis of documentary evidence of Medieval vineyards in England. Even with this increase, the maximum it showed for the Medieval Warm Period did not reach temperatures recorded in central England in 2007. The MBH99 finding was supported by cited reconstructions by Jones et al. 1998, Pollack, Huang & Shen 1998, Crowley & Lowery 2000 and Briffa 2000, using differing data and methods. The Jones et al. and Briffa reconstructions were overlaid with the MBH99 reconstruction in Figure 2.21 of the IPCC report.

Output: 2007


Input: Consider Input: What service was ceased about a year before Newcastle was added as a departure port?, Context: From Newcastle International Ferry Terminal, at North Shields, Danish DFDS Seaways run a service to IJmuiden (near Amsterdam). The DFDS ferry service to Gothenburg, Sweden, ceased at the end of October 2006 – the company cited high fuel prices and new competition from low-cost air services as the cause – and their service to Bergen and Stavanger, Norway was terminated late 2008. Since summer 2007, Thomson cruise lines have included Newcastle as a departure port on its Norwegian and Fjords cruise.


Output: Gothenburg, Sweden