TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Brian Cohen is born in a stable next door to the one in which Jesus is born, which initially confuses the three wise men who come to praise the future King of the Jews. Brian grows up an idealistic young man who resents the continuing Roman occupation of Judea. While attending Jesus' Sermon on the Mount, Brian becomes infatuated with an attractive young rebel, Judith. His desire for her and hatred for the Romans lead him to join the "People's Front of Judea", one of many fractious and bickering independence movements, who spend more time fighting each other than the Romans. After several misadventures, and escaping from Pontius Pilate, Brian winds up in a line-up of would-be mystics and prophets who harangue the passing crowd in a plaza. Forced to come up with something plausible in order to blend in and keep the guards off his back, Brian repeats some of what he had heard Jesus say, and quickly attracts a small but intrigued audience. Once the guards have left, Brian tries to put the episode behind him, but he has unintentionally inspired a movement. He grows frantic when he finds that some people have started to follow him around, with even the slightest unusual occurrence being hailed as a miracle. Each of their responses ever growing in fervor and intensity making it harder and harder for him to get away from them. Yet because of the mob's excitement, they end up leaving Brian alone. After which he sees Judith is one who didn't leave, and they then spend the night together. In the morning, Brian, completely naked, opens the curtains to discover an enormous crowd outside his mother's house who proclaim him to be the Messiah. Brian's mother protests, "He's not the Messiah, he's a very naughty boy."; and, "There's no Messiah in here. There's a mess all right, but no Messiah." Yet all of her attempts at dispersing the crowd are rebuffed. Furthermore, once Brian addresses them, he also finds that he is unable to change their minds. His followers are completely committed to their beliefs in and of Brian's divinity. They immediately seize upon everything he says and does as points of doctrine. The hapless Brian finds no solace as people have even mobbed his mother's house. They fling their afflicted bodies at him demanding miracle cures and divine secrets. After sneaking out the back, Brian is then finally captured and scheduled to be crucified. Meanwhile, a huge crowd has assembled outside the palace. Pilate (together with the visiting Biggus Dickus) tries to quell the feeling of revolution by granting them the choice of one person to be pardoned. The crowd, however, shouts out names containing the letter "r", mocking Pilate's rhotacistic speech impediment. Eventually, Judith appears in the crowd and calls for the release of Brian, which the crowd echoes since the name also contains an "r". Pilate agrees to "welease Bwian". His order is eventually relayed to the guards, but in a scene that parodies the climax of the film Spartacus, various crucified people all claim to be "Brian of Nazareth" and the wrong man is released. Various other opportunities for a reprieve for Brian are denied as, one by one, his "allies" (including Judith and his mother) step forward to explain why they are leaving the "noble freedom fighter" hanging in the hot sun. Hope is renewed when a crack suicide squad from the "Judean People's Front" (not to be confused with the People's Front of Judea) come charging towards the Romans, but rather than fighting to release Brian or the other prisoners, they commit mass suicide as a political protest. Condemned to a long and painful death, Brian finds his spirits lifted by his fellow sufferers, who break into song with "Always Look on the Bright Side of Life."[6]

SOLUTION: Where is Brian Cohen born ?

PROBLEM: Nuclear receptor co-repressor (N-CoR) plays important role in transcriptional control mediated by several tumor suppressor proteins. Recently, we reported a role of misfolded-conformation dependent loss (MCDL) of N-CoR in the activation of oncogenic survival pathway in acute promyelocytic leukemia (APL). Since N-CoR plays important role in cellular homeostasis in various tissues, therefore, we hypothesized that an APL like MCDL of N-CoR might also be involved in other malignancy. Indeed, our initial screening of N-CoR status in various leukemia and solid tumor cells revealed an APL like MCDL of N-CoR in primary and secondary tumor cells derived from non-small cell lung cancer (NSCLC). The NSCLC cell specific N-CoR loss could be blocked by Kaletra, a clinical grade protease inhibitor and by genistein, an inhibitor of N-CoR misfolding previously characterized by us. The misfolded N-CoR presented in NSCLC cells was linked to the amplification of ER stress and was subjected to degradation by NSCLC cell specific aberrant protease activity. In NSCLC cells, misfolded N-CoR was found to be associated with Hsc70, a molecular chaperone involved in chaperone mediated autophagy (CMA). Genetic and chemical inhibition of Lamp2A, a rate limiting factor of CMA, significantly blocked the loss of N-CoR in NSCLC cells, suggesting a crucial role of CMA in N-CoR degradation. These findings identify an important role of CMA-induced degradation of misfolded N-CoR in the neutralization of ER stress and suggest a possible role of misfolded N-CoR protein in the activation of oncogenic survival pathway in NSCLC cells.

SOLUTION: Which is the receptor for substrates of Chaperone Mediated Autophagy?

PROBLEM: After a discussion last week. "Do SCHOOL Libraries Need Books?" the comments from readers included some first-hand views from students. Below are excerpts from their observations on how studying has changed and how they use libraries. It makes little difference whether the books you are reading is electronic or paper. But if you want a place to read, a library is still the place to go. As a kid in school, I often avoid the study hall noises and go to the quiet school library. The library is a place. A learning place. Modern technology won't change the library as long as things are learned. -Scott Being a student I am aware that many of us seldom look at the books in the library unless told to do so by a teacher as a requirement for an assignment. It takes time to find the very book you want at the library, and it may not be necessary to do so. More and more students, such as myself, use the internet for nearly every assignment. There are countless online resources for us to use with a click of the mouse. What's more, books are very expensive and schools could put that money towards charities. -Hayley H I hope schools continue to have libraries. As a student, I know there is a difference between reading something on a screen and something printed. When I read something in a book that I do not understand or want to look further into. I record it and will research later or discuss with someone. With a screen (especially online) I will instantly access the information and look into the question at hand, which interrupts my reading and especially my imagination. -Allie To me, it depends on the purpose of the books. As a student, I prefer to do research online. Online research is faster and more efficient. But when I'm reading for pleasure, I ly refuse to give up a real book. The tactile sensation and freedom that real books give you really makes the reading experience more enjoyable. So my suggestion is that schools have more digital collections for research and scholarly work, and a good selection of interesting and age-appropriate fiction and nonfiction for pleasure reading. -CM

SOLUTION:
Who prefers printed books when reading for fun?