instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Schimke immuno-osseous dysplasia (OMIM 242900) is an uncommon autosomal-recessive multisystem disease caused by mutations in SMARCAL1 (swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1), a gene encoding a putative chromatin remodeling protein. Neurologic manifestations identified to date relate to enhanced atherosclerosis and cerebrovascular disease. Based on a clinical survey, we determined that half of Schimke immuno-osseous dysplasia patients have a small head circumference, and 15% have social, language, motor, or cognitive abnormalities. Postmortem examination of 2 Schimke immuno-osseous dysplasia patients showed low brain weights and subtle brain histologic abnormalities suggestive of perturbed neuron-glial migration such as heterotopia, irregular cortical thickness, incomplete gyral formation, and poor definition of cortical layers. We found that SMARCAL1 is highly expressed in the developing and adult mouse and human brain, including neural precursors and neuronal lineage cells. These observations suggest that SMARCAL1 deficiency may influence brain development and function in addition to its previously recognized effect on cerebral circulation.
answer:
Mutations in which gene cause Schimke immune-osseous dysplasia?


question:
The susceptibility to arbekacin (ABK) of methicillin-resistant Staphylococcus aureus (MRSA) was investigated to find out how it related to aac(6')/aph(2") gene. In 49 isolates of MRSA for which MIC of ABK ranged from 0.125 to 64 micrograms/ml, the MICs of ABK for 38 strains carrying aac(6')/aph(2") gene were widely distributed from 0.25 to 64, whereas those for 11 strains without that gene were all < or = 0.5 microgram/ml. Residual rate of ABK activity was higher than that of gentamicin after the reaction with each crude enzyme preparation extracted from 3 isolates of MRSA, carrying aac(6')/aph(2") and aad(4',4") genes. Furthermore, 97 strains of MRSA isolated at Kanagawa prefecture in Japan in 1999 were all sensitive to ABK, although 28 strains of them carried aac(6')/aph(2") gene. These results showed that ABK resistance was not necessarily related to carrying aac(6')/aph(2") gene in clinical isolates of MRSA.
answer:
What is MRSA?


question:
You must have been troubled by when to say "I love you" because it is one of the greatest puzzles in our life. What if you say it first and your partner doesn't love you back? Or if they do say it but you don't feel they mean it? Being the first to declare your love can be never racking and risky and can leave you feeling as vulnerable as a turtle with no shell. But is the person who says it first really in a position of weakness? Doesn't it pay to hold back, play it cool and wait until the other half has shown their hand faster? "A really good relationship should be about being fair and being equal," says psychologist Sidney Crown. "But love is seldom equal." "All relationships go through power struggles but," he says, "if a love imbalance continues for years, the rot will set in." That feeling of "I've always loved you more" may be subverted (,) for a time, but it never goes away completely and it often emerges in squabbling . In love, at least, the silent, withholding type is not always the most powerful. "The strongest one in a relationship is often the person who feels confident enough to talk about their feelings," says educational psychologist Ingrid Collins. Psychosexual therapist Paula Hall agrees. "The one with the upper hand is often the person who takes the initiative." In fact, the person who says "I love you" first may also be the one who says "I'm bored with you' first." Hall believes that much depends on how "I love you" is said and the motivation of the person saying it. Is it said when they're drunk? Is it said before their partner flies off on holiday, and what it really means is "Please don' t be unfaithful to me" ? By saying "I love you", they are really saying "Do you love me?" If so, wouldn't it just be more honest to say that. Collins agrees that intention is everything. "It's not what is said, but how it's said. What it comes down to is the sincerity of the speaker."
answer:

What is the most important for you to consider when somebody say "I love you" to you?