In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

[Q]: Paragraph: The SARS 3C-like proteinase (SARS-3CLpro), which is the main proteinase of the SARS coronavirus, is essential to the virus life cycle. This enzyme has been shown to be active as a dimer in which only one protomer is active. However, it remains unknown how the dimer structure maintains an active monomer conformation. It has been observed that the Ser139-Leu141 loop forms a short 3 10 -helix that disrupts the catalytic machinery in the inactive monomer structure. We have tried to disrupt this helical conformation by mutating L141 to T in the stable inactive monomer G11A/R298A/Q299A. The resulting tetra-mutant G11A/L141T/R298A/Q299A is indeed enzymatically active as a monomer. Molecular dynamics simulations revealed that the L141T mutation disrupts the 3 10 -helix and helps to stabilize the active conformation. The coil-3 10 -helix conformational transition of the Ser139-Leu141 loop serves as an enzyme activity switch. Our study therefore indicates that the dimer structure can stabilize the active conformation but is not a required structure in the evolution of the active enzyme, which can also arise through simple mutations. 
 Title: Conformational Flexibility of a Short Loop near the Active Site of the SARS-3CLpro is Essential to Maintain Catalytic Activity OPEN
[A]: True


[Q]: Paragraph: We evaluated if interventions aimed at air travellers can delay establishment of a SARS-CoV-2 outbreak in a previously unaffected country. Methods: For countries with no sustained SARS-CoV-2 transmission and with no shared border with affected regions we simulated arriving infected air travellers. We assessed the effectiveness of syndromic screening at departure and/or arrival & traveller sensitisation to the COVID-2019-like symptoms with the aim to trigger rapid self-isolation and reporting on symptom onset to enable contact tracing. We assumed that syndromic screening would reduce the number of infected arrivals and that traveller sensitisation reduce the average number of secondary cases. We report the minimal expected delay achievable in 50% (75% & 97.5%) of simulations. In the simulations we account for uncertainty in the number of secondary cases in the absence of air traveller targeted interventions and the arrival times of infected cases and also present sensitivity analyses on arrival rates of infected travellers and the effectiveness of traveller sensitisation. Results: Under baseline assumptions exit and entry screening combined with traveller sensitisation can delay a local SARS-CoV-2 outbreak by at least 83 (75% of simulations: at least 36, 97.5% 8) days while there is no more than 1 infected traveller per week. The benefit of entry screening is small if exit screening is effective: the combination of only exit screening and traveller sensitisation can delay an outbreak by at least 76 (75%: 33, 97.5%: 7) days. With increasing rates of infected travellers, less effective sensitisation or without screening these delays shrink rapidly to a week or less. Conclusion: Syndromic screening and traveller sensitisation in combination could delay outbreaks in yet unaffected countries and support local containment efforts, but only if infected traveller numbers are very low. . CC-BY 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity. is the (which was not peer-reviewed) The copyright holder for this preprint . 
 Title: Title: Interventions targeting air travellers early in the pandemic may delay local outbreaks of SARS-CoV-2
[A]: True


[Q]: Paragraph: Background: Coronavirus disease 2019 is pandemic and has caused illness to many people worldwide. This review aimed to summarize and analyze the herbal formulae provided by the guidelines for their pattern identifications (PIs) and compositions of herbs to treat patients with COVID-19. Methods: We searched 7 data sources for eligible traditional medicine guidelines up to March 6, 2020 and found a total of 28 traditional medicine guidelines that provide treatment measures for COVID-19. : Of the 28 guidelines, there were 26 government-issued Chinese guidelines and 2 Korean guidelines. After standardizing the terminology of the PIs and herbal formulae, there were 8 PIs and 23 herbal formulae for the mild stage, 11 PIs and 31 herbal formulae for the moderate stage, 8 PIs and 21 herbal formulae for the severe stage, and 6 PIs and 23 herbal formulae for the recovery stage in the Chinese guidelines. In the Korean guidelines, there were 4 PIs and 15 herbal formulae for the mild stage, 3 PIs and 3 herbal formulae for the severe stage, and 2 PIs and 2 herbal formulae for the recovery stage. In the frequency analysis of herbs, Glycyrrhizae Radix et Rhizoma was found to be the herb with the highest frequency of usage in the Chinese guidelines. Conclusion: This review can be used as guidance for the traditional medicine treatment of COVID-19. Clinical evidence is needed in the future to evaluate the efficacy of traditional medicine. Page 3 of 24 J o u r n a l P r e -p r o o f Ephedrae Herba 5-10g, Armeniacae Semen Amarum 5-10g, Gypsum Fibrosum 30-50g, Forsythiae Fructus 10-20g, Scutellariae Radix 5-10g, Bupleuri Radix 10-15g, Coicis Semen 10-15g, Magnoliae Officinalis Cortex 5-10g, Poria Sclerotium 10-15g, Glycyrrhizae Radix et Rhizoma 5-10g Ephedrae Herba 6g, Armeniacae Semen Amarum 15g, Amomi Tsao-ko Fructus 6g, Arecae Semen 10g, Cicadae Periostracum 10g, Forsythiae Fructus 20g, Atractylodis Rhizoma 10g, Platycodonis Radix 10g, Scutellariae Radix 15g, Coicis Semen 20g, Arctii Semen 15g, Moslae Herba 12g Huo Po Xia Ling Tang* + Yin Qiao San Agastachis Herba 15g, Perillae Folium 15g, Sojae Semen Preparatum 15g, Atractylodis Rhizoma 15g, Magnoliae Officinalis Cortex 10g, Angelicae Decursivae Radix 15g, Bupleuri Radix 15g, Scutellariae Radix 10g, Artemisiae Annuae Herba 20g, Armeniacae Semen Amarum 10g, Osterici seu Notopterygii Radix et Rhizoma 10g, Lonicerae Flos 15g, Forsythiae Fructus 15g Dampness Encumbering the Exterior and Interior Ephedrae Herba 6g, Armeniacae Semen Amarum 9g, Coicis Semen 18g, Amomi Fructus Rotundus 9g, Agastachis Herba 9g, Magnoliae Officinalis Cortex 12g, Pinelliae Rhizoma Praeparatum cum alumine 9g, Poria Sclerotium 12g, Polyporus 9g, Scutellariae Radix 9g, Forsythiae Fructus 12g, Glycyrrhizae Radix et Rhizoma 6g Pathogen Invading the Stomach and Intestines No specific PI Qingfei Paidu Tang Ephedrae Herba 9g, Glycyrrhizae Radix et Rhizoma 6g, Armeniacae Semen Amarum 9g, Gypsum Fibrosum 15~30g, Cinnamomi Ramulus 9g, Alismatis Rhizoma 9g, Polyporus 9g, Atractylodis Macrocephalae Rhizoma 9g, Poria Sclerotium 15g, Bupleuri Radix16g, Scutellariae Radix 6g, Pinelliae Rhizoma 9g, Zingiberis Rhizoma Recens 9g, Asteris Radix 9g, Farfare Flos 9g, Belamcandae Rhizoma 9g, Asari Herba 6g, Dioscoreae Rhizoma 12g, Aurantii Fructus 6g, Citri Unshius Pericarpium 6g, Agastachis Herba 9g 
 Title: Journal Pre-proof Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines
[A]:
False