Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: Marjanovic took over Ciguli Miguli only after his proposal for Nikola Tesla, a biography of the famous engineer and inventor, had been rejected by Jadran Film.
[A]: What production company was involved in Ciguli Miguli?


[Q]: In chronic lymphocytic leukemia (CLL) signals from the B cell receptor (BCR) play a major role in disease development and progression. In this light, new therapies that specifically target signaling molecules downstream of the BCR continue to be developed. While first studies on the selective small molecule inhibitor of Bruton's tyrosine kinase (Btk), Ibrutinib (PCI-32765), demonstrated that Btk inhibition sensitizes CLL cells to apoptosis and alters their migratory behavior, these studies however did not address whether Btk-mediated signaling is involved in the process of CLL leukemogenesis. To investigate the requirement of Btk signaling for CLL development, we modulated Btk expression in the IgH.ET CLL mouse model, which is based on sporadic expression of the simian oncovirus SV40 T-antigen in mature B cells. To this end, we crossed IgH.ET mice on a Btk-deficient background or introduced a human Btk transgene (CD19-hBtk). Here we show that Btk deficiency fully abrogates CLL formation in IgH.ET mice, and that leukemias formed in Btk haplo-insufficient mice selectively expressed the wild-type Btk allele on their active X chromosome. Conversely, Btk overexpression accelerated CLL onset, increased mortality, and was associated with selection of non-stereotypical BCRs into CLL clones. Taken together, these data show that Btk expression represents an absolute prerequisite for CLL development and that Btk mediated signaling enhances leukemogenesis in mice. We therefore conclude that in CLL Btk expression levels set the threshold for malignant transformation.
[A]: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?


[Q]: As we all know , the language is a very important tool for people to communicate with each other. In most of the languages , people usually begin their conversations by a kind of small talk -a casual form of conversation that "breaks the ice" or fills an awkward silence between people . That is to say , small talk means the little things we talk about to start a conversation . In English-speaking countries such as Britain, people often make small talk about the weather. " Nice day, isn't it?" "Terrible weather , isn't it?" However, we still have something special about small talk. It must be about something which both people have the same opinion about. The purpose of small talk is to let both people agree on something. This makes meeting people easier and more comfortable . People usually agree about the weather, so it is a safe topic for small talk. But people often disagree about religion or politics so these are not suitable topics for small talk. The topics for small talk also depend on where the conversation is taking place. At basketball matches, people make small talk about the game they are watching. "Great game , isn't it?" At train stations, people may talk about the transport system . " The train service is terrible, isn't it?"
[A]:
What is the favorite topic of small talk for English people ?