Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
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Question: Clozapine is the least likely anti-psychotic to induce extrapyramidal symptoms (EPS).

Answer: non-adverse drug event


Question: We believe that this is the first description of acute hepatitis caused by an idiosyncratic adverse reaction to gliclazide or to one of its metabolites.

Answer: adverse drug event


Question: Drug-induced fever should be considered in patients who have unexplained high temperatures during diltiazem therapy.

Answer:
adverse drug event