Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a small vessel disease of the brain caused by mutations in the NOTCH3 gene. CADASIL progresses, in some cases, to subcortical dementia with a particular cognitive impairment. Different diseases in the dementia spectrum share a central cholinergic and sensorimotor plasticity alteration. We aimed to study different intracortical circuits and sensorimotor plasticity in CADASIL patients using transcranial magnetic stimulation protocols, and to determine whether these characteristics correlated with the results of clinical neuropsychological evaluation. Ten CADASIL patients and 10 healthy subjects were included in the study. All subjects underwent a transcranial magnetic stimulation study examining different intracortical circuits. Sensorimotor plasticity was also assessed using a paired associative stimulation and extensive neuropsychological tests. CADASIL patients showed a lack of intracortical facilitation, short latency afferent inhibition and sensorimotor plasticity when compared with control subjects. CADASIL patients also showed an altered neuropsychological profile. Correlation between sensorimotor plasticity and neuropsychological alterations was observed in CADASIL patients. These results suggest that acetylcholine and glutamate could be involved in the dementia process in CADASIL and that abnormal sensorimotor plasticity correlates with the neuropsychological profile in CADASIL patients.

Answer: Which gene is involved in CADASIL?


Question: The Santer-Poos Ministry II was the government of Luxembourg between 14 July 1989 and 13 July 1994.

Answer: What year did Santer-Poos Ministry II start?


Question: When I was a baby, I entertained you and made you laugh.Whenever I was "bad", you'd shake your finger at me and ask, "How could you?"--but then you'd give up, and roll me over for a belly scratch and I believed that life could not be any more perfect. My housetraining was a long process, because you were terribly busy, but we worked on that together. We went for long walks, runs in the park and car rides. We stopped for ice cream. I took long naps in the sun waiting for you to come home at the end of the day. Gradually, you began spending more time at work and on your career, and more time searching for a human mate.Eventually, you fell in love.She, now your wife, is not a dog person, but I still welcomed her into our home.I was happy because you were happy.Then the human babies came along and I shared your excitement, I was fascinated by their pinkness, how they smelled, and I wanted to mother them too. Your wife was afraid I would bite them.But nevertheless, as they began to grow, I became their friend.Now, you have a new job in another city and you and they will be moving to an apartment that does not allow pets.You've made the right decision for your "family", but there was a time when I was your only family. I was excited about the car ride until we arrived at the dog pound.It smelled of dogs and cats, of fear, of hopelessness.You filled out the paperwork and said, "I know you will find a good home for her".They shrugged and gave you a pained look.The children were in tears as they waved me goodbye.And "How could you?" were the only three words that swept over my mind. Is it better to live with hope or without hope? At first, whenever anyone passed my pen , I rushed to the front, hoping it was you, that you had changed your mind and that this was all a bad dream. My beloved master, I will think of you and wait for you forever.I hope you receive more faithfulness from your family than you showed to me.

Answer:
Who tells this story?