In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

[Q]: One sentence summary: CmpA is an OmpA-like protein in Legionella pneumophila that is required for efficient intracellular replication in both primary macrophages and in the environmental host Acanthamoeba castellanii. Editor: Akio Nakane The OmpA-like protein domain has been associated with peptidoglycan-binding proteins, and is often found in virulence factors of bacterial pathogens. The intracellular pathogen Legionella pneumophila encodes for six proteins that contain the OmpA-like domain, among them the highly conserved uncharacterized protein we named CmpA. Here we set out to characterize the CmpA protein and determine its contribution to intracellular survival of L. pneumophila. Secondary structure analysis suggests that CmpA is an inner membrane protein with a peptidoglycan-binding domain at the C-teminus. A cmpA mutant was able to replicate normally in broth, but failed to compete with an isogenic wild-type strain in an intracellular growth competition assay. The cmpA mutant also displayed significant intracellular growth defects in both the protozoan host Acanthamoeba castellanii and in primary bone marrow-derived macrophages, where uptake into the cells was also impaired. The cmpA phenotypes were completely restored upon expression of CmpA in trans. The data presented here establish CmpA as a novel virulence factor of L. pneumophila that is required for efficient intracellular replication in both mammalian and protozoan hosts.
[A]: A conserved OmpA-like protein in Legionella pneumophila required for efficient intracellular replication


[Q]: The requirement for negative pressure isolation procedures has been an accepted component of pediatric care to protect patients and staff from highly infectious respiratory agents. Surveys regarding airborne isolation were distributed to 43 pediatric emergency departments at US children's hospitals with 26 responses. There was a median of 5 airborne isolation rooms, a median of 4 of those with negative pressure, and 61% without an ante-room. Capacity to manage pediatric patients infected with a highly pathogenic airborne-transmitted organism during an epidemic is limited.
[A]: Airborne pathogen isolation capability in emergency departments of US children's hospitals


[Q]: Cut-off Cut-off Supplementary Figure 1 | Setting cut-off to identify links and hidden source. (a) Coarse-grained distribution of element values ln(1 − λ i )a ij times −1 in the reconstructed vector X of all nodes in a Newman-Watts small-world network (NW), where bin accumulation is implemented for the original distribution. The peak centered at zero corresponds to null connections and the other corresponds to actual links. A cut-off value can be set within the gap between the two peaks. (b) The values of ln(1 − λ i )a ij times -1 in the reconstructed vector X for Erdös-Rényi random networks (ER), Watts-Strogatz small-world networks (WS), NW and Barabási-Albert scale-free networks (BA), where green and yellow points correspond to existent links and null connections, respectively. All the networks share the same cut-off value of about 0.13. (c) Coarse-grained distribution of the structural variance σ in the NW network, where bin accumulation is exercised on the original distribution. The largest peak centered close zero corresponds to nodes of indirect neighbors of the hidden source and the large positive values of σ are associated with the immediate neighbors of the hidden source. A cut-off can be set within the largest gap. (d) The variance σ * i of element values in the reconstructed vector x of all nodes in the presence of a hidden source for ER, WS, NW and BA networks, where green and yellow points correspond to immediate neighbors and indirect neighbors of the hidden source, respectively. All the networks share the same cut-off values of about σ * i = 0.9. The network size in a,b is 200 and in c,d is 50, Θ = 0.25, ∆ = 0.45, λ i and δ i are uniformly distributed in the ranges (0.2, 0.4) and (0.4, 0.6), respectively. SIS dynamics are used for the illustration. Panels a and c correspond to Fig. 2a with nt = 0.4 and Fig. 5 in the main text, respectively.
[A]:
Supplementary Figures