Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

Q: Paragraph: Although Pfizer continues to test the drug, called dacomitinib, in another Phase III study, hopes for its success have now largely faded, according to ISI Group analyst Mark Schoenebaum. “We believe consensus expectations (for the drug) will be close to zero given today’s readout” of unsuccessful trial results, Schoenebaum said in a research note. In one of the failed trials, called ARCHER 1009, patients given Pfizer’s once-daily pill did not show improved survival without the cancer worsening, compared with Roche Holding AG’s widely used Tarceva (erlotinib). Tarceva is the current standard of care in patients with mutated forms of a protein called Epidermal Growth Factor Receptor (EGFR). The protein plays a role in normal regulation of cell growth, but when mutated is believed to cause cells to proliferate and thereby help spur various types of cancer. Dacomitinib is designed to block several types of Epidermal Growth Factor receptors, while Tarceva and similar treatments for lung cancer target only one type of receptor. Cowen and Co had forecast annual sales of $500 million by 2020 for dacomitinib, if it were approved for lung cancer. That would make it a moderate-sized product for Pfizer, the largest U.S. drugmaker, which has annual revenue of $50 billion. Schoenebaum said there has been little investor interest in the drug and that Wall Street had expected it to generate annual sales of only $300 million by 2018. The second failed trial, named BR.26, involved patients that previously had failed to benefit from chemotherapy as well as from treatment with an EGFR inhibitor. Overall survival of patients taking the Pfizer drug was not prolonged in the study, compared with patients given a placebo. Pfizer said adverse events seen with dacomitinib were consistent with those seen in smaller earlier studies. In the meantime, Pfizer said dacomitinib is also being tested in a third late-stage trial, called ARCHER 1050, among patients with advanced non-small cell lung cancer who have not received prior treatment. The study will compare dacomitinib with Iressa (gefitinib), an EGFR inhibitor sold by AstraZeneca Plc. Results from that study are expected in 2015. Pfizer shares were little changed in morning trading on the New York Stock Exchange. Claim: Pfizer lung cancer drug fails in two large studies.

A: Pfizer Inc on Monday said one of its experimental drugs had failed to meet its goals in two late-stage studies among patients who had received prior treatment for advanced non-small cell lung cancer, the most common form of the disease.
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Q: Paragraph: "Major industries in Wisconsin have sustained significant economic losses during the coronavirus pandemic, and nowhere is that more apparent than in the tourism sector. Wisconsin plays host to about 112 million tourists in a year, according to the WorldAtlas website, and 2019 was ""a record setting year, and the largest year for Wisconsin in at least a decade"" said Wisconsin Secretary of Tourism-designee Sara Meaney. However, the loss of revenue in 2020 is massive, she said. In a May 24, 2020, appearance on the WISN-TV (Channel 12) show ""UpFront,"" she said, ""Unemployment in our state in general is at about a quarter of our population. It’s actually over 50% of travel and tourism-related jobs that are now facing unemployment."" Meaney went on to say that just in the weeks since the pandemic hit, the state has lost more than a billion dollars in tourism dollars. ""Since the week ending March 14, Wisconsin actually saw a drop in tourism spending compared to last year of $1.7 billion,"" she said. Wisconsin’s tourism industry should come back a bit this summer. Some northern resorts have opened and state campgrounds reopened June 10, according to the Wisconsin Department of Natural Resources. But that tourism recovery could be an uphill climb if Meaney is correct that year-over-year weekly travel spending in the state has dropped $1.7 billion since March. Let’s take a look. Craig Trost, Wisconsin Department of Tourism communications director, pointed PolitiFact Wisconsin to the U.S. Travel Association, which commissioned a study by Tourism Economics, the firm the department uses for its economic impact data. The U.S. Travel Association is a national, non-profit organization representing the travel industry, with various sectors — including transportation, lodging, retail, recreation, leisure and entertainment and food service, meetings and trade shows. Adam Sacks, president of Tourism Economics, in an email to PolitiFact Wisconsin, explained that the analysis is based on a combination of factors: daily hotel data (nights and revenue) from STR, a research company that tracks the hospitality industry; flight data (seats and passengers) from Airline Data Inc. and the Transportation Security Administration; and drive travel data (outside 50 mile radius) from Arrivalist based on mobile device data. Trost said the week ending March 14 was significant because that is when COVID-19 began significantly impacting tourism spending. ""Since the beginning of March, the COVID-19 pandemic has resulted in over $176 billion in losses for the U.S. travel economy,"" the report states. According to the report, Wisconsin’s  year-over-year net change in weekly travel spending from the week ending March 28 to the week ending May 16 was down about $200 million each week. When going back earlier in March, the report notes losses for the week ending March 14 at $17 million and the week ending March 21 of $50 million. That brings the total to $1.775 billion. Romy Snyder, CEO/President of the Wisconsin Dells Visitor and Convention Bureau, said it will take time to correctly analyze and know the  financial impact of COVID-19 on Wisconsin Dells. ""We do know the loss of visitors has been detrimental to the local tourism economy,"" Snyder said in an email. ""According to 2019 numbers, the spring and summer seasons account for 66% of direct visitor spending in Wisconsin Dells."" Snyder said area businesses are ready to welcome visitors. ""Wisconsin Dells’ businesses are working to accommodate current visitors to the area in a safe manner by increasing sanitation procedures and limiting capacities and hours of operation,"" Snyder said. ""We know Wisconsin Dells has strong brand awareness in the Midwest, which will help our area when people are ready to travel and are looking for an accessible vacation destination with a diversity of activities."" Jon Jarosh of Destination Door County said area businesses have been getting ready and opening up. ""Everybody has a little different protocol in terms of what they’re going to allow at their particular business,"" Jarosh said on the same ""UpFront"" program where Meaney appeared via remote. ""We’re asking our visitors and residents that are out and about to just respect the individual businesses and what they are asking for. But by and large most businesses are going to be asking that their customers do wear a face covering of some sort and also just practice social distancing guidelines."" A major Dells attraction, Noah’s Ark water park, set its opening date for June 20, the first day of summer. The water park plans a number of precautions in line with recommendations from the Centers for Disease Control and Prevention. Those precautions include social distancing and limiting capacity not only in the park itself but also on specific attractions and in buildings. The park is requiring guests to RSVP for the day they want to visit, and visitors must buy tickets in advance online. Walk-up tickets will not be sold. Meaney said the state’s tourism losses have topped $1.7 billion since March. Data from weekly studies commissioned by the U.S. Travel Association, an organization with over 1,100 members nationwide, found that beginning the week ending March 14, when the COVID-19 crisis first began to significantly impact tourism spending, Wisconsin was down $17 million compared to a year earlier. The drop in year-over-year travel spending in the state mounted weekly, with the latest available report reporting a drop of $214 million for the week ending May 16. That brings the state tourism sector drop to $1.775 billion since the week ending March 14. Claim: “Since the week ending March 14, Wisconsin actually saw a drop in tourism spending compared to last year of $1.7 billion.”

A: Decrease in tourism dollars became apparent the week of March 14, with a year-over-year drop of $17 million. Year-over-year decreases continued to mount, with drops of about $200 million per week statewide. A study commissioned by the U.S. Travel Association found year-over-year decreases totaled $1.775 billion from March 14 to May 16.
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Q: Paragraph: “There’s a little snobbery about running on a treadmill,” said David Siik, a track and field sprinter turned treadmill class fitness instructor at Equinox, the upscale chain of fitness centers. “Most racers are a little ashamed of running indoors.”  Siik, who is now based in Los Angeles, turned reluctantly to treadmill running after a post-college stint in New York City. “I was sick of running into cars trying to get to Central Park,” he explained, “and New York in January is not always the friendliest place to run.”  Now the humble treadmill has him hooked. “I still really enjoy running outside, but there is nothing better than the ability to calculate and monitor your goals on a treadmill,” he said. “You’re running on this computer.”  Siik, 33, believes too many people get on the treadmill without knowing what to do. “They hit ‘on’ and then they’re clueless,” said Siik, who tries to bring the energy of a spin class to his 45-minute treadmill workout class, which includes three runs, each progressively harder, after an initial warm-up. The treadmill is by far the most popular cardio machine, accounting for 58 percent of home fitness sales in 2012, according to the National Sporting Goods Association, a percentage that has stayed consistent over the past years. The elliptical trainer, at eight per cent, is a distant second. Melanie Douglass, a Utah-based dietitian and trainer with ICON Health and Fitness, whose products include cardio equipment, has also taught classes on the treadmill, which she calls her preferred piece of equipment. “People always work more efficiently (on the treadmill), because the motor and belt help you maintain a consistent pace,” said Douglass. She said people err when they go too slow, or do the same thing day after day. “Exercise is not supposed to be comfortable,” she explained. “You have to challenge your body.”  Dr. Michele Olson, professor of exercise physiology at Auburn University at Montgomery in Alabama, said besides teaching proper running and walking form, classes help the exerciser learn “the bells and whistles” of the modern machine. And unlike outdoor running, training on a treadmill ensures you are running at your intended pace, she said. Simply varying the grade, or incline, every minute will push up the calorie burning. But that’s just the beginning. “We’ve researched and studied walking and running on treadmills in all directions,” Olson said. “You burn more calories moving sideways and backwards, particularly at walking speeds.”  She even likes to see people with their feet on the floor behind the treadmill walking on it with their hands. “After a set of push-ups, treadmill walk with your hands,” she suggests. “Your shoulder girdle will become a beast providing you with both upper body strength and endurance in those under-aerobically used upper body muscles.”  Siik said using a treadmill is the best 30 to 45 minutes of cardio anyone can get inside a gym. “The beautiful thing about a treadmill is that it will never lie to you. It’s a brutally honest machine,” he added. Claim: Treadmill classes mix it up with workhorse of the gym.

A:
For many outdoor runners the idea of pounding a treadmill means trading daylight for drudgery but as the air chills, fitness experts say treadmill classes can hone efficiency and form and add a dash of glamour to indoor running.
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