In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Q: Question: The denaturation of proteins: 
 Options:  <1> It is accompanied by the loss of their activity. <2> It supposes the rupture of peptide bonds. <3> It is always an irreversible process. <4> Alter its primary structure. <5> It is carried out by chaperone proteins.

A: 1
****
Q: Question: Which of these statements is NOT a characteristic of phase I clinical trials? 
 Options:  <1> They usually have non-therapeutic goals. <2> They can be done in healthy volunteers. <3> They can be done in patients. <4> They are usually randomized. <5> They are usually open.

A: 4
****
Q: Question: From a tissue to which oligomycin is added, it can be expected that: 
 Options:  <1> Consume oxygen and produce ATP. <2> Do not consume oxygen and produce ATP. <3> Consume oxygen and do not produce ATP. <4> Increase the production of ATP. <5> Neither consume oxygen nor produce ATP.

A:
5
****