TASK DEFINITION: In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
PROBLEM: Paragraph: Background: The detrimental role of viruses has been well described in CF, although the pattern of virus infections has not been investigated in a longitudinal study. The primary aim was to determine the feasibility of fortnightly parent collected swabs in young children with CF. Methods: Children under three years with CF were recruited. Nasal swabs were collected by parents every fortnight and during periods of symptoms over 12 months. Nasal swabs were posted and virus detected using real-time PCR. Results: Only 27% of the patients completed the study to 10 months, although 98% of the swabs returned were adequate for analysis. Mould was observed growing on 23% of the returned swabs. There was no evidence to demonstrate relationships with symptoms and viruses, prolonged symptoms, prolonged shedding or patterns of virus infections. Conclusions: This study highlights the need to further investigate the role of viruses in children with CF using a robust method of frequent collection in children for a longitudinal study, with appropriate storage and shipping techniques to avoid mould growth or other potential contaminants. 
 Title: Original Article

SOLUTION: False

PROBLEM: Paragraph: Inspired by bioactive biaryl-containing natural products found in plants and the marine 19 environment, a series of synthetic compounds belonging to the azaBINOL chiral ligand family 20 was evaluated for antiviral activity against HIV-1. Testing of 39 unique azaBINOLs in a single-21 round infectivity assay resulted in the identification of three promising antiviral compounds, 22 including 7-isopropoxy-8-(naphth-1-yl)quinoline (azaBINOL B#24), which exhibited low-23 micromolar activity. The active compounds and several close structural analogues were further 24 tested against three different HIV-1 envelope pseudotyped viruses as well as in a full-virus 25 replication system (EASY-HIT). Mode-of-action studies using a time-of-addition assay indicated 26 that azaBINOL B#24 acts after viral entry but before viral assembly and budding. HIV-1 reverse 27 transcriptase (RT) assays that individually test for polymerase and RNase H activity were used to 28 demonstrate that B#24 inhibits RNase H activity, most likely allosterically. Further binding 29 analysis using bio-layer interferometry (BLI) showed that B#24 interacts with HIV-1 RT in a 30 highly specific manner. These results indicate that azaBINOL B#24 is a potentially viable, novel 31 
 Title: Biological Evaluation of Molecules of the azaBINOL Class as Antiviral Agents: 1 Specific Inhibition of HIV-1 RNase H Activity by 7-Isopropoxy-8-(naphth-1-yl)quinoline 2 3 4 5

SOLUTION: False

PROBLEM: Paragraph: Supplementary Text 1: Details of specimen collection, processing, polymerase chain reaction 34 assays, quality control measures, and assay parameters used to identify respiratory viruses. Specimen collection 36 All swabs were collected using a plastic-shaft, rayon-budded swab in a transport tube with a foam 37 pad reservoir soaked with viral transport medium (Virocult MW950, Medical Wire & Equipment, 38 Wiltshire, England). A single swab was used to sample both nostrils. 39 Quality Control measures 40 A known amount of whole equine herpesvirus (EHV) spiked into each sample assessed nucleic 41 acid extraction quality and presence of polymerase chain reaction (PCR) inhibitors. 1 Any extract 42 having a >3 cycle-threshold (Ct) difference to that of the expected value by EHV real-time PCR 43 assays was considered to have failed quality control and the sample was re-extracted. Specimen quality was assessed by testing for a marker of human genomic DNA, endogenous 46 retrovirus-3 (ERV-3). 2 We have demonstrated previously that among specimens with an ERV-3 Ct a adjusted for clustering using sandwich estimators to account for within-infant correlation between observations; b Individual rhinovirus species do not add up to 'All rhinovirus' detections because of a combination of more than one rhinovirus species detected within the same ARI episode, or single new virus detection episodes where HRV positive specimens could not be sequenced. 
 Title: Viruses causing lower respiratory symptoms in children younger than 2-years of age: 1 findings from the ORChID birth cohort. 2

SOLUTION:
True