Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Q: Laboratory investigations confirmed a metabolic acidosis (pH 7.15) and hyperchloremia.

A: non-adverse drug event
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Q: The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the problem of methamphetamine-related keratitis.

A: adverse drug event
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Q: Co-trimoxazole red cell aplasia in leukaemia.

A:
adverse drug event
****