Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy. We enrolled 457 patients who had active rheumatoid arthritis despite long-term methotrexate therapy in a 6-month, double-blind, placebo-controlled trial. The primary outcome was the American College of Rheumatology (ACR) 20 response (which indicates at least a 20% reduction in the number of both tender and swollen joints and improvement in at least three of five other criteria) at month 6. R788, at a dose of 100 mg twice daily and at a dose of 150 mg once daily, was significantly superior to placebo at month 6 (ACR 20 response rates of 67% and 57%, respectively, vs. 35%; P<0.001 for the comparison of both doses with placebo). It was also significantly superior with respect to ACR 50, which indicates at least a 50% improvement (43% and 32% vs. 19%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.007 for the comparison of the 150-mg dose with placebo) and ACR 70 (28% and 14% vs. 10%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.34 for the comparison of the 150-mg dose with placebo). A clinically significant effect was noted by the end of the first week of treatment. Adverse effects included diarrhea (in 19% of subjects taking the 100-mg dose of R788 vs. 3% of those taking placebo), upper respiratory infections (14% vs. 7%), and neutropenia (6% vs. 1%). R788 was associated with an increase in systolic blood pressure of approximately 3 mm Hg between baseline and month 1, as compared with a decrease of 2 mm Hg with placebo; 23% of the patients taking R788 vs. 7% of the patients receiving placebo required the initiation of or a change in antihypertensive therapy. In this phase 2 study, a Syk inhibitor reduced disease activity in patients with rheumatoid arthritis; adverse events included diarrhea, hypertension, and neutropenia. Additional studies will be needed to further assess the safety and efficacy of Syk-inhibition therapy in patients with rheumatoid arthritis. (Funded by Rigel; ClinicalTrials.gov number, NCT00665925.) 
 Question: Which enzyme is inhibited by a drug fostamatinib?
spleen tyrosine kinase

Context: In a New York City residence, Pierre Delacroix (Damon Wayans) rises to begin his daily routine. Brushing his teeth, he gives us by voice over a definition of satire. He tells us that with the rise of the Internet, video and interactive games, his field as a television writer has seen a drop in popularity. Meanwhile, in a dilapidated building, squatter Womack (Tommy Davidson) wakes up his friend Manray (Savion Glover) for a day of work. This consists of travelling to the CNS (Continental Network System) building where Delacroix works, and Manray tap dancing to entertain the workers. They then collect money from the workers. The men see Delacroix walk by, and ask him for monetary help in the form of work of some kind.Delacroix walks into a staff meeting late and is immediately castigated by his boss, Thomas Dunwitty (Michael Rapaport). Dunwitty informs the staff that CNS has poor ratings. He says he wants them to write funnier material, and ends the meeting. In the privacy of his office, Dunwitty tells Delacroix that the material Delacroix's been writing for him seems like it's about white people with black faces. Dunwitty asserts that Delacroix is an "oreo" with his Harvard education, because he won't write a "n----r show."The next day, Delacroix and his assistant Sloan Hopkins (Jada Pinkett Smith) talk. They've decided that Manray is the solution to his problem. Delacroix plans to write a show that will be so "offensive and racist," it will prove his point that the network only wants to see black buffoons on the air. Delacroix simply hopes to be fired, so he can be let go of his contract with CNS. Manray and Womack ask at the receptionist's desk for a "Delapoint" and the men working there tell them to step outside. However, Sloan steps into the lobby, sees what's happening, and escorts Manray and Womack to Delacroix's office. Delacroix explains to them that he has an idea for a television pilot, and they can make money with it. His main request is that Manray changes his name to Mantan, in an apparent homage to black character actor Mantan Moreland.On Sloan's walk home, she runs into her big brother Big Blak Afrika F/K/A Julius (Yasiin Bey). In Sloan's apartment, Julius and Sloan argue about his values, and he tells her to introduce him and his political hip-hop crew, the Mau Maus, to Delacroix.Delacroix has another meeting with Dunwitty. Delacroix proposes that the network start a variety show called "Mantan: The New Millenium Minstrel Show." Delacroix says that new faces are needed for the show, and has Sloan bring in Manray and Womack. The two men, respectively renamed "Mantan" and "Sleep'n Eat," will exhibit a range of stereotypical traits, Delacroix explains. Sloan is opposed to the proceedings, and suggests that there will be protest of the show they are planning. To seal the package, Manray dances atop a table in front of Dunwitty -- who immediately leaves to try to sell the show's concept to his executive bosses.Delacroix, Sloan and another woman hold auditions for the show. The first group of people (The Roots) audition to be the show's house band, The Alabama Porch Monkeys. After they perform, a dancer, a vulgar man shouting "I be smackin' my hoes," and a didgeridoo player all audition. The next hopeful is Honeycutt (Thomas Jefferson Byrd), an actor who bungles Shakespearean quotes and proclaims "N----s is a beautiful thing." Sloan's brother's group, the Mau Maus then do a fiery, confrontational performance; Pierre states via voice over that there is no place for them in his plan.Delacroix looks over a revised script for the show and confronts Dunwitty and his co-writer, Jukka about their alterations to it that even he finds racially offensive. Delacroix says that he won't be responsible for their changes, which Dunwitty says are to make the show funnier. Dunwitty says he knows black people better than Delacroix does, telling him, "Look 
 Question: The jokes and puns are extremely what?
racist

Context: The median age in the city was 35.1 years. 24.2% of residents were under the age of 18; 7.9% were between the ages of 18 and 24; 33.8% were from 25 to 44; 24.6% were from 45 to 64; and 9.5% were 65 years of age or older. The gender makeup of the city was 48.6% male and 51.4% females. 
 Question: Which age group is smaller: 25 to 44 or 45 to 64?

45 to 64