instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: Immune responses are a double-edged sword. Effective and appropriate immune responses capable of controlling viral infection while also largely preserving tissue integrity, are critical for host survival. Too strong immune responses might result in immune pathology, while too weak immune responses might cause viral persistence. Physiologic ageing is accompanied with a decline in the normal functioning of the immune system, which is termed as "immunosenescence". We show that aged mice (16-19 months old) are more resistant to influenza A virus (IAV) infection than the young mice. Strong immune responses in the young mice after IAV infection result in faster clearance of virus, but also cause severe lung injury and higher mortality rate. While in the aged mice, the delayed and milder immune responses contribute to reduced pulmonary damage, and are still capable to clear the infection even with a slower kinetics, displaying a more resistant phenotype during IAV infection. Hence, our work demonstrates that moderate immune responses as a decline with ageing in the aged mice balance the immune pathology and viral clearance, might be beneficial for the host during certain circumstances. Our results provide important insight to our basic knowledge of immunosenescence and immune defenses to invading pathogens. Further, our results indicate that age factors should be considered when investigating the vaccination and therapeutic strategies for severe IAV infection. 
 Title: Aged Mice are More Resistant to Influenza Virus Infection due to Reduced Inflammation and Lung Pathology
answer:
True


question:
Paragraph: The Mediterranean diet is rich in fruits and vegetables, monounsaturated fatty acids from olive oil, and is complemented with the traditional use of culinary and medicinal herbs and spices. An important feature of this diet is the negative association with the incidence of metabolic syndrome, which is characterized by increased risk of cardiovascular disease. Conformity to the Mediterranean diet has also been linked to a decreased risk of cardiovascular disease and cancer in US populations. Plants that originated in the Mediterranean basin have been used for centuries in botanical therapies. Many of these plants are believed to prevent and/or cure a wide spectrum of ailments based on their content in bioactive components that exert anti-oxidant, anti-infl ammatory, anticarcinogenic, anti-diabetic, and anti-thrombotic functions. This chapter underlines the health benefi ts that may derive from utilization through dietary assumption or medicinal applications of a selected group of plant products including extracts and specifi c bioactive components found in rosemary, licorice, chamomile, and olive oil. Each section provides a scientifi c analysis of the most recent literature and attempts to highlight the mechanisms of action and molecular targets of bioactive components derived from these plants. 
 Title: Health Benefi ts of Traditional Culinary and Medicinal Mediterranean Plants
answer:
False


question:
Paragraph: Several arenaviruses can cause viral hemorrhagic fever, a severe disease with case-fatality rates in hospitalized individuals ranging from 15-30%. Because of limited prophylaxis and treatment options, new medical countermeasures are needed for these viruses classified by the National Institutes of Allergy and Infectious Diseases (NIAID) as top priority biodefense Category A pathogens. Recombinant consensus interferon alpha (cIFN-a) is a licensed protein with broad clinical appeal. However, while cIFN-a has great therapeutic value, its utility for biodefense applications is hindered by its short in vivo half-life, mode and frequency of administration, and costly production. To address these limitations, we describe the use of DEF201, a replicationdeficient adenovirus vector that drives the expression of cIFN-a, for pre-and post-exposure prophylaxis of acute arenaviral infection modeled in hamsters. Intranasal administration of DEF201 24 h prior to challenge with Pichindé virus (PICV) was highly effective at protecting animals from mortality and preventing viral replication and liver-associated disease. A significant protective effect was still observed with a single dosing of DEF201 given two weeks prior to PICV challenge. DEF201 was also efficacious when administered as a treatment 24 to 48 h post-virus exposure. The protective effect of DEF201 was largely attributed to the expression of cIFN-a, as dosing with a control empty vector adenovirus did not protect hamsters from lethal PICV challenge. Effective countermeasures that are highly stable, easily administered, and elicit long lasting protective immunity are much needed for arena and other viral infections. The DEF201 technology has the potential to address all of these issues and may serve as a broad-spectrum antiviral to enhance host defense against a number of viral pathogens. Citation: Gowen BB, Ennis J, Russell A, Sefing EJ, Wong M-H, et al. (2011) Use of Recombinant Adenovirus Vectored Consensus IFN-a to Avert Severe Arenavirus Infection. PLoS ONE 6(10): e26072. 
 Title: Use of Recombinant Adenovirus Vectored Consensus IFN-a to Avert Severe Arenavirus Infection
answer:

True