Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

[EX Q]: Paragraph: The N.C. Department of Health and Human Services said in a news release on Tuesday that it’s working with the Buncombe and Henderson County health departments to track down additional information. Legionella bacteria can become a health concern when they grow and spread in human-made water systems like hot water tanks, air conditioning systems and other sources that are not properly maintained. State Epidemiologist Dr. Zack Moore said it’s not yet known if people attending the fair might have been exposed to Legionella bacteria. Moore says people who attended the fair and are experiencing cough, fever or shortness of breath should call their health care provider right away. Claim: 2 health departments investigate Legionnaires’ disease.
[EX A]: Health departments in two North Carolina counties are looking into multiple cases of Legionnaires’ disease at the N.C. Mountain State Fair.

[EX Q]: Paragraph: Cancer patients increasingly are having their care guided by gene tumor boards, a new version of the hospital panels that traditionally decided whether surgery, radiation or chemotherapy would be best. These experts study the patient’s cancer genes and match treatments to mutations that seem to drive the disease. “We dissect the patient’s tumor with what I call the molecular microscope,” said Dr. Razelle Kurzrock, who started a board at the University of California, San Diego, where Cairnes is treated. It’s the kind of care many experts say we should aim for — precision medicine, the right drug for the right person at the right time, guided by genes. There are success stories, but also some failures and many questions: Will gene-guided care improve survival? Does it save money or cost more? What kind of gene testing is best, and who should get it? “I think every patient needs it,” especially if cancer is advanced, said Kurzrock, who consults for some gene-medicine companies. “Most people don’t agree with me — yet. In five years, it may be malpractice not to do genomics.” Few people get precision medicine today, said Dr. Eric Topol, head of the Scripps Translational Science Institute. “The only thing that’s gone mainstream are the words.” HOW IT WORKS NOW If you have a cancer that might be susceptible to a gene-targeting drug, you may be tested for mutations in that gene, such as HER2 for breast cancer. Some breast or prostate cancer patients also might get a multi-gene test to gauge how aggressive treatment should be. Then most patients get usual guideline-based treatments. If there’s no clear choice, or if the disease has spread or comes back, doctors may suggest tumor profiling — comprehensive tests to see what mutations dominate. That’s traditionally been done from a tissue sample, but newer tests that detect tumor DNA in blood — liquid biopsies — are making profiling more common. The tests cost about $6,000 and many insurers consider them experimental and won’t pay. Gene tumor boards analyze what the results suggest about treatment. They focus on oddball cases like a breast cancer mutation in a colon cancer patient, or cancers that have widely spread and are genetically complex. The only options may be experimental drugs or “off-label” treatments — medicines approved for different situations. But as tumor profiling grows, it’s revealing how genetically diverse many tumors are, and that oddball cases are not so rare, said Dr. John Marshall. He heads the virtual tumor board at Georgetown Lombardi Comprehensive Cancer Center that also serves cancer centers in Pennsylvania, North Carolina, Michigan and Tennessee. “There is a little bit of faith” that testing will show the right treatment, but it’s not a sure thing, said Dr. Lee Schwartzberg, who heads one participating center, the West Cancer Center in Memphis. Dr. Len Lichtenfeld, the American Cancer Society’s deputy chief medical officer, is optimistic yet wary. Drugs that target BRAF mutations work well for skin cancers called melanomas, but less well for lung or colon cancers. “Just because a mutation occurs it doesn’t mean that drug is going to work in that cancer,” he said. LUCKY CASES When it does, results can be dramatic. Cairnes’ cancer was between her stomach and esophagus, and had spread to her liver, lungs and lymph nodes. Tissue testing found 10 abnormal genes, but on the liquid biopsy only EGFR popped out as a good target. Two drugs aim at that gene but aren’t approved for her type of cancer. A tumor board advised trying both — Erbitux and Tarceva, the drug her husband also had taken. Within two weeks, she quit using pain medicines. After two months, her liver tumor had shrunk roughly by half. There are signs that cancer may remain, but it is under control. She feels well enough to travel and to take care of her granddaughter. “I’m very, very grateful to have a targeted therapy,” Cairnes said. “I cannot expect a better outcome than what we’re seeing right now,” said her doctor, Shumei Kato. WHAT STUDIES SHOW But is gene-guided treatment better than usual care? French doctors did the first big test, with disappointing results. About 200 patients with advanced cancer were given whatever their doctors thought best or off-label drugs based on tumor profiling. Survival was similar — about two months. Another French study, reported in June, was slightly more encouraging on survival but exposed another problem: No drugs exist for many gene flaws. Tests found treatable mutations in half of the 2,000 participants and only 143 got what a tumor board suggested. Some doctors worry that tumor boards’ recommending off-label treatments diverts patients from research that would benefit all cancer patients. For example, the American Society of Clinical Oncology’s TAPUR study tests off-label drugs and shares results with their makers and federal regulators. LETTING PATIENTS CHOOSE Ann Meffert, who lives on a dairy farm in Waunakee, Wisconsin, endured multiple standard treatments that didn’t defeat her bile duct cancer. “She was going to be referred to hospice; there was not much we could do,” said Dr. Nataliya Uboha, who took the case to a tumor board at the University of Wisconsin-Madison. The panel gave several options, including off-label treatment, and Meffert chose a study that matches patients to gene-targeting therapies and started on an experimental one last October. “Two weeks in, I started feeling better,” she said, and when she saw test results, “I couldn’t believe the difference.” Many lung spots disappeared and the liver tumor shrank 75 percent. She is not cured, though, and doctors are thinking about next steps. And that could involve a fresh look at her tumor genes. ___ Marilynn Marchione can be followed at @MMarchioneAP __ This Associated Press series was produced in partnership with the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. Claim: Ultra-personal therapy: Gene tumor boards guide cancer care.
[EX A]: Doctors were just guessing a decade ago when they gave Alison Cairnes’ husband a new drug they hoped would shrink his lung tumors. Now she takes it, but the choice was no guesswork. Sophisticated gene tests suggested it would fight her gastric cancer, and they were right.

[EX Q]: Paragraph: About 2 years ago my wife and I were on a cruise through the western Mediterranean aboard a Princess liner. At dinner we noticed an elderly lady sitting alone along the rail of the grand stairway in the main dining room. I also noticed that all the staff, ships officers, waiters, busboys, etc., all seemed very familiar with this lady. I asked our waiter who the lady was, expecting to be told she owned the line, but he said he only knew that she had been on board for the last four cruises, back to back. As we left the dining room one evening I caught her eye and stopped to say hello. We chatted and I said, “I understand you’ve been on this ship for the last four cruises.” She replied, “Yes, that’s true.” I stated, “I don’t understand” and she replied, without a pause, “It’s cheaper than a nursing home.” So, there will be no nursing home in my future. When I get old and feeble, I am going to get on a Princess Cruise Ship. The average cost for a nursing home is $200 per day. I have checked on reservations at Princess and I can get a long term discount and senior discount price of $135 per day. That leaves $65 a day for:  1. Gratuities which will only be $10 per day. 2. I will have as many as 10 meals a day (of fantastic food, not institutional food) if I can waddle to the restaurant, or I can have room service (which means I can have breakfast in bed every day of the week). 3. Princess has as many as three swimming pools, a workout room, free washers and dryers, and shows every night. 4. They have free toothpaste and razors, and free soap and shampoo. 5. They will even treat you like a customer, not a patient. An extra $5 worth of tips will have the entire staff scrambling to help you. 6. I will get to meet new people every 7 or 14 days! 7. TV broken? Light bulb need changing? Need to have the mattress replaced? No problem! They will fix everything and apologize for your inconvenience. 8. Clean sheets and towels every day, and you don’t even have to ask for them. 9. If you fall in the nursing home and break a hip you are on Medicare; if you fall and break a hip on the Princess ship they will upgrade you to a suite for the rest of your life. 10. There is always a doctor on board. Now hold on for the best! Do you want to see South America, the Panama Canal, Tahiti, Australia, New Zealand, Asia, or name where you want to go? Princess will have a ship ready to go. So don’t look for me in a nursing home, just call shore to ship. PS: And don’t forget, when you die, they just dump you over the side at no charge. Origins:   Although the “cruise ship” recounting has become the more widespread, the earlier form taken by this piece of e-lore featured not a luxury liner but a hotel. In 2003 this waggish diatribe against the cost of nursing home care had its writer swearing to check into a Holiday Inn when the grey hairs became too many. By 2004, some of the numbered items now found in the “cruise ship” tale were in place, albeit in a version that claimed Holiday Inn rather than Princess as substitute elder care housing (e.g., “TV broken? Light bulb need changing? Need to have the mattress replaced? No problem! They will fix everything and apologize for your inconvenience”). By 2005 more numbered items had been added, including some cruise-specific ones (e.g., “There is always a doctor on board” and “And don’t forget, when you die, they just dump you over the side at no charge”). Also by 2005, what had begun as one writer’s claim about his or her fanciful future plans had come to be presented as the actual remarks of an old woman living that life on a cruise ship. It is at this intersection that folklore and reality: while the account of the “elderly lady” has clearly evolved from earlier pieces about pie-in-the-sky retirement plans involving Holiday Inn, some people of advanced years have indeed made their homes on cruise ships. Bea Muller, an 86-year-old retiree, took up residence on Cunard’s Queen Elizabeth 2 on 5 January 2000. Her husband had passed away while the couple was on a world cruise eleven months earlier, and rather than opt for a retirement home, Mrs. Muller sold her house and possessions and booked herself onto the ship. Instead of submitting a monthly or yearly fee, in 2001 Muller was reported to be paying as she went, booking one cruise after another. Thanks to her frequent traveler discounts, her overall costs amounted to about $5,000 a month. (Cruise prices have increased since then, which is something those entertaining similar plans should keep in mind. Also, Muller’s accommodations were small and windowless: a 10×10 foot cabin that barely fits a bed, radio, and television, with a bathroom smaller than the average closet found in a typical home.) Its cramped quarters aside, Muller was happy with her life aboard a ship. “I’ve got full-time maid service, great dining rooms, doctors, medical center (where she volunteers), a spa, beauty salon, computer center, entertainment, cultural activities and, best of all, dancing and bridge.”  (Muller passed away in 2013, and the Queen Elizabeth 2 was retired from service in 2008.) Bea Muller was not the first long-time cruiser: Cunard had a previous guest, Clair MacBeth, who lived aboard ship for 14 years. As to whether living out one’s golden years aboard a cruise ship is a viable alternative to spending them in a retirement home, a geriatrician at Northwestern University says such a plan is a feasible and cost-effective alternative to assisted-living facilities. Dr. Lee Lindquist, an instructor at Northwestern’s Feinberg School of Medicine, compared the costs (over a 20-year life expectancy) of moving to an assisted-living facility, a nursing home and a cruise ship, including the expense of treating acute illnesses, Medicare reimbursement and other factors. She determined that the net cost of cruise-ship living was only about $2,000 more than the alternatives ($230,000 versus $228,000) and offered a higher quality of service. “Cruise ships offer such a range of amenities — such as three meals a day, often with escorts to meals if needed, room service, entertainment, accessible halls and cabins, housekeeping and laundry services and physicians on board — that they could actually be considered a floating assisted-living facility,” says Lindquist. Lindquist says the plan would work best for seniors who need a minimal amount of care. “Seniors who enjoy travel, have good or excellent cognitive function but require some assistance with activities of daily living are the ideal candidates for cruise-ship care. Just as with assisted living, if residents became acutely ill or got to the point that they needed a higher level of care, they would have to leave.” Although Lindquist’s findings would seem to support the premise of it being cheaper to live on a luxury liner than in a retirement home, we’d want to examine her research vis-a-vis the types of care facilities she looked at and the cruise-ship costs she factored in before we’d feel comfortable about offering an opinion on her assessment. (She might have compared only very expensive retirement homes against the cheapest accommodations offered on ships that are less than well thought of, for example.) However, whatever the validity of Lindquist’s findings, cost is but one of the elements to the choice of where to reside after retirement. Golden agers who decide to make their permanent homes on cruise ships sacrifice proximity to family and friends; their nearest and dearest are no longer just a short car ride away. Those devoted to their children and grandchildren might well deem that too high a price to pay, no matter what the spreadsheet says about the relative financial costs. Likewise, those who lack progeny but who are involved in their communities or who are part of a number of strong friendships may not want to opt for the vagabond life, because it would mean abandoning that which gives them joy. Claim: Some people have eschewed retirement homes in favor of living on cruise ships.
[EX A]:
Also, life on a cruise ship means one acquaintance after another, but no permanent ongoing connections of any depth. Fellow passengers disembark to return to their regular lives at the termination of their one- or two-week holidays, which means friendships struck up with them land in the “We’ll keep in touch” bin very quickly. As for staff, while serial cruisers can strike up deeply affable relationships with some of the line’s employees, these rapports are inherently limited by their very nature: no matter how close such associations appear to be, ships’ employees are required to be deferential to paying passengers, so the friendship-critical element of honesty can never be part of such dealings. Making a cruise ship one’s permanent address, therefore, will not be for everyone. While those at ease with a steady diet of the superficial will thrive, those who require the comfort of at least a few real friendships will likely feel lonely even though they live among crowds.