TASK DEFINITION: Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
PROBLEM: Context: As elderly people go about their day in Manhattan, Harry walks along a sidewalk with his tabby cat Tonto on a leash, quoting Shakespeare's "King Lear" as he goes. Harry stops in at a grocer, buys some good food for his cat, and jokes that his sexual days are over.Next Harry meets his old friend Jacob on a bench, and tells him that his apartment building is being torn down to build a parking lot. Jacob complains about capitalists, and reassures Harry that he could always move in with him.On the way home, a kid tries to steal Harry's groceries and knocks him down. Harry is helped up by Leroy, his building super.Harry gets into his apartment and talks to Tonto, lamenting that he's been mugged four times in the past year, and that the whole city is getting run down.Some time later, police show up to forcibly remove Harry and his furniture from the building. Harry continues to spout "King Lear" while his son Burt arrives to pick him up.Harry goes to live with Burt and his wife and two grown sons in the suburbs. His younger grandson, Norman, has taken a vow of silence, leading to obvious tension with his brother and parents. Harry later asks Norman for the books that explain his beliefs.Harry goes back to his familiar bench to talk with Jacob, and they both agree it's been a long time since either has been with a woman. Jacob reminisces about his first sexual encounter with a servant girl when he was 14.Harry invites Leroy to dinner at Burt's house, and he plays the piano while Leroy dances to the tune. Leroy later comments that he lives with his 90-year-old mother and can't find a new job, which leads Burt's wife to question why Harry is not getting help from his two other kids.Knowing that he is a burden to Burt, Harry goes to look for his own apartment, but finds that the place he wants will not take cats. He then tells Burt he is going to Chicago to visit Shirley, Burt's sister, but before he leaves he stops at a city morgue to identify the body of Jacob, who has died with no relatives. Harry cries after recalling Jacob's story of losing his virginity.Burt takes Harry to the airport, but Harry soon learns that he can't go through security with Tonto, so he takes a cab to get a bus. Along the route, Harry asks the bus driver to stop so that Tonto can relieve himself, whereupon the cat runs away across a cemetery. The bus driver leaves Harry behind with his luggage, and when Tonto returns, Harry scolds him.Harry walks to a used car lot and buys an old Chevy for $250. He then checks into a motel and calls Burt to tell him what has happened, realizing in the process that his driver's license expired in 1958.Harry drives west rather slowly, with Tonto on the dashboard, recalling how he wanted to drive across the country when he was younger, but his wife and kids came along. He remembers they had many good times though. He confesses to Tonto that he has a great fear of pain, and that when he dies he would like to go quickly rather than the slow way his wife Annie died.Harry picks up two young hitchhikers, one of whom soon gets another ride, while the other a girl named Ginger continues west with Harry. She claims she is 16, and is running away from home to a commune in Boulder.Harry and Ginger get a motel for the night, and after she comes out of the bathroom half-naked, Harry is prompted to recall the first girl he loved, Jessie, whom he has not seen in 50 years. Ginger suggests that they go to see her, even though it's out of their way, and they eventually find her in a nursing home.At first Harry thinks Jessie remembers him, but her thoughts are marked by senility; she calls him Alex yet remembers his wife Annie. Then she suddenly asks Harry to dance, which they do while Ginger looks on.Harry 
 Question: Who is Harry's travelling companion?

SOLUTION: tonto

PROBLEM: Context: The film depicts the construction and ultimate demolition of a metaphorical wall. Though the film's symbolism is open to interpretation, the wall itself clearly reflects a sense of isolation and alienation.Pink (Bob Geldof), the protagonist (and unreliable narrator) of the film, is a rock star, one of several reasons behind his apparent depressive and detached emotional state. He is first seen in a quiet hotel room, having trashed it. The opening music is not by Pink Floyd, but is the Vera Lynn recording of "The Little Boy that Santa Claus Forgot". During the following scenes, it is revealed that Pink's father, a British soldier, was killed in action during World War II during Pink's infancy. The reference is almost certainly to the death of Roger Waters' real-life father, Eric Fletcher Waters, who died in combat in Italy during Operation Shingle (the Battle of Anzio) in February 1944.The movie then flashes back to Pink as a young English boy growing up in the early 1950s. Throughout his childhood, Pink longs for a father figure after he learns his father died in the war. At school, he is humiliated by his mean and stern teacher for writing poems in class. The poems that the teacher seizes from him and reads aloud are lyrics from "Money" from the Pink Floyd album Dark Side of the Moon. Pink is also affected by his overprotective mother who spoils him by giving him whatever he wants.As an adult, Pink eventually gets married as his fame as a rock star grows, but he and his wife grow apart and she has an affair while Pink is on tour. When Pink learns of the affair, he compensates with expensive materialistic possessions and turns to a willing groupie (Jenny Wright), whom he brings back to his hotel room only to trash it in a fit of violence, causing her to flee the room in terror.Pink slowly begins to lose his mind to metaphorical "worms". He shaves off all of his body hair (an incident inspired by former bandmate Syd Barrett, who appeared at a 1975 recording session of Wish You Were Here, having shaved his eyebrows and body hair) and, while watching The Dam Busters on television, morphs into his neo-Nazi alter-ego. Pink's manager (Bob Hoskins), along with the hotel manager (Michael Ensign) and some paramedics, break into the hotel room and discover Pink. They take him away into a waiting limousine outside the hotel and inject him with drugs to enable him to perform.The drugs cause Pink to hallucinate and he fantasises that he is a neo-Nazi dictator, his concert is a rally. His followers proceed to attack ethnic minorities and rape the white girlfriend of a black man. Later, Pink holds a rally in suburban London, singing "Waiting for the Worms". The scene is inter-cut by images of animated marching hammers that goose-step across ruins.Pink screams "Stop!" and takes refuge in a bathroom stall at the concert venue, reciting poems which would later be used as lyrics on Pink Floyd's "Your Possible Pasts" from The Final Cut album and "5:11 AM (The Moment Of Clarity)" from Roger Waters' The Pros and Cons of Hitch Hiking.In a climatic animated sequence, Pink puts himself on trial. He is depicted as a small, pink rag doll that rarely moves. The judge is a giant pair of buttocks, with two backward facing legs, an anus for a mouth and a scrotum for a chin. The lawyer is a tall, menacing, vulturelike man and the schoolmaster is an abusive, hateful marionette. After hearing from the parties and witnesses (Pink's wife and mother), the judge orders the wall to be torn down. The wall explodes and shows a montage of events from the entire film.The film concludes with three children cleaning up a pile of debris after an earlier riot. It is unknown whatever has happened to Pink, leaving the viewer to decide. 
 Question: What kind of doll is Pink depicted as?

SOLUTION: small pink rag doll that rarely moves

PROBLEM: Context: Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor B ligand (RANKL) has been identified as a pivotal paracrine mediator of progesterone function in mouse mammary gland development and mammary carcinogenesis. Whether the factor has the same role in humans is of clinical interest because an inhibitor for RANKL, denosumab, is already used for the treatment of bone disease and might benefit breast cancer patients. We show that progesterone receptor (PR) signaling failed to induce RANKL in PR(+) breast cancer cell lines and in dissociated, cultured breast epithelial cells. In clinical specimens from healthy donors and intact breast tissue microstructures, hormone response was maintained and RANKL expression was under progesterone control, which increased RNA stability. RANKL was sufficient to trigger cell proliferation and was required for progesterone-induced proliferation. The findings were validated in vivo where RANKL protein expression in the breast epithelium correlated with serum progesterone levels and the protein was expressed in a subset of luminal cells that express PR. Thus, important hormonal control mechanisms are conserved across species, making RANKL a potential target in breast cancer treatment and prevention. 
 Question: To the ligand of which receptors does Denosumab (Prolia) bind?

SOLUTION:
rankl