Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
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Question: Context: NADPH oxidase (Nox) family enzymes are one of the main sources of cellular reactive oxygen species (ROS), which have been shown to function as second messenger molecules. To date, seven members of this family have been reported, including Nox1-5 and Duox1 and -2. With the exception of Nox2, the regulation of the Nox enzymes is still poorly understood. Nox1 is highly expressed in the colon, and it requires two cytosolic regulators, NoxO1 and NoxA1, as well as the binding of Rac1 GTPase, for its activity. In this study, we investigate the role of the tyrosine kinase c-Src in the regulation of ROS formation by Nox1. We show that c-Src induces Nox1-mediated ROS generation in the HT29 human colon carcinoma cell line through a Rac-dependent mechanism. Treatment of HT29 cells with the Src inhibitor PP2, expression of a kinase-inactive form of c-Src, and c-Src depletion by small interfering RNA (siRNA) reduce both ROS generation and the levels of active Rac1. This is associated with decreased Src-mediated phosphorylation and activation of the Rac1-guanine nucleotide exchange factor Vav2. Consistent with this, Vav2 siRNA that specifically reduces endogenous Vav2 protein is able to dramatically decrease Nox1-dependent ROS generation and abolish c-Src-induced Nox1 activity. Together, these results establish c-Src as an important regulator of Nox1 activity, and they may provide insight into the mechanisms of tumor formation in colon cancers. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?

Answer: nadph oxidase 1


Question: Context: This article's plot summary may be too long or excessively detailed. Please help improve it by removing unnecessary details and making it more concise. (April 2015) (Learn how and when to remove this template message) Part 1 Alice in Wonderland[edit] The first part opens with Alice helping Mother set the table for tea time. Although thankful for her daughter's help, Mother tells Alice that she is still not grown-up enough to join the adults at tea. Alice goes outside to see her sister (played by Natalie's real-life older sister Sharee Gregory), but gets bored of reading a book with no pictures. Her sister tells her that she will understand when she grows up, but Alice thinks she is already grown up (after all, she's seven and a half). While playing with her kitten, Dinah, the White Rabbit comes running by, saying he's late. Wondering where he is going, Alice follows him and tumbles into his rabbit hole. (Unlike the book and most movie versions, this rabbit hole appears to be dark and spooky.) Alice finds herself in a hall with many doors, and all of them locked. On a table is a key which she can use to open one small door. Yet the door is far too small to even fit her head in. A small bottle appears labeled "Drink Me". She comes back to the table and puts it to her lips. Doing this, she shrinks to the right size for the door, but can no longer reach the key to open it. She then sees a small box which she opens and finds a little cake with the words "Eat Me" on it. She then grows to over nine feet tall. Frustrated with the thought of being stuck at nine feet tall, she begins to cry. Her tears fall on the floor and flow under the cracks. The White Rabbit appears, but frightened of the giant Alice runs away dropping his fan and gloves. Using the fan makes Alice shrink again to a size small enough to crawl into one of the cracks, which takes her diving in her pool of tears. While swimming in the pool of her own tears, she meets The Lory Bird, The Dodo Bird and the Mouse, who tells her why he hates dogs and cats ("I Hate Dogs and Cats"). Alice catches up with the White Rabbit. He mistakes Alice for his housemaid Mary Ann and orders her to go get his fan and gloves from his house. While searching his house, Alice curiously finds another "Drink Me" bottle and it makes her sprout to her full nine-foot character once again. Angry at Alice, the rabbit and his friend Pat the Pig try to employ Bill the Lizard to remove Alice by pulling her out the chimney. Having tried unsuccessfully the White Rabbit and Pat begin throwing berries at her which turn into little cakes. She eats one and shrinks to back to size. After running away she meets the Caterpillar who tells her the story ("You are Old, Father William"). She then goes to the house of The Duchess and her pepper loving, plate throwing cook. Finding the house too violent and hateful, she takes the Duchess' baby away, but then it turns into a pig. She meets the Cheshire Cat, who tells her that she can't get out of this land ("There's No Way Home"). He then gives her directions to see either the March Hare or the Mad Hatter, but warns Alice that they, along with everyone else, are mad. Alice finds the Mad Hatter, March Hare, and the Dormouse having an outdoor tea party, and sits down to join them. As tea time entertainment the Mad Hatter, who does not like her version of twinkle, twinkle little star, sings Alice a song of his own ("Laugh"). Upset by the rudeness of the Mad Tea Party, Alice runs off back on her quest for the White Rabbit, and meets a baby fawn in the forest, the only normal thing she's seen so 
 Question: Who plays a prank on the queen?

Answer: the deck of cards


Question: Context: Two functions of the female reproductive system are similar to the functions of the male reproductive system: producing gametes and secreting a major sex hormone. In the case of females, however, the gametes are eggs, and they are produced by the ovaries. The hormone is estrogen, which is the main sex hormone in females. Estrogen has two major roles: During adolescence, estrogen causes the changes of puberty. It causes the reproductive organs to mature. It also causes other female traits to develop. For example, it causes the breasts to grow and the hips to widen. During adulthood, estrogen is needed for a woman to release eggs from the ovaries. The female reproductive system has another important function, which is not found in males. It supports a baby as it develops before birth. It also gives birth to the baby at the end of pregnancy. The female reproductive organs include the ovaries, fallopian tubes, uterus, and vagina. These organs are shown in Figure 22.3, along with some other structures of the female reproductive system. Find each organ in the drawing as you read about it below. For a cartoon about the female reproductive system, watch this video: [Link] The two ovaries are small, oval organs on either side of the abdomen. Each ovary contains thousands of eggs. However, the eggs do not develop fully until a female has gone through puberty. Then, about once a month, an egg is released by one of the ovaries. The ovaries also secrete estrogen. The two fallopian tubes are thin tubes that are connected to the uterus and extend almost to the ovaries. The upper end of each fallopian tube has fingers (called fimbriae) that sweep an egg into the fallopian tube when it is released by the ovary. The egg then passes through the fallopian tube to the uterus. If an egg is fertilized, this occurs in the fallopian tube. The uterus is a hollow organ with muscular walls. The uterus is where a baby develops until birth. The walls of the uterus stretch to accommodate the growing fetus. The muscles in the walls contract to push the baby out during birth. The uterus is connected to the vagina by a small opening called the cervix. The vagina is a cylinder-shaped organ that opens to the outside of the body. The other end joins with the uterus. Sperm deposited in the vagina swim up through the cervix, into the uterus, and from there into a When a baby girl is born, her ovaries contain all of the eggs they will ever produce. But these eggs are not fully developed. They develop only after the female reaches puberty at about age 12 or 13. Then, just one egg develops each month until she reaches her 40s or early 50s. Human eggs are very large cells. In fact, they are the largest of all human cells. You can even see an egg without a microscope. Its almost as big as the period at the end of this sentence. Like a sperm cell, an egg cell is a haploid cell with half the number of chromosomes of other cells in the body. Unlike a sperm cell, the egg lacks a tail and contains a lot of cytoplasm. Egg production takes place in the ovaries. It occurs in several steps: 1. Before birth, special cells in the ovaries go through mitosis to make identical daughter cells. 2. The daughter cells then start to divide by meiosis. However, they go though only the first of the two cell divisions of meiosis at this time. They remain in that stage until the girl goes through puberty. 3. After puberty, an egg develops in an ovary about once a month. As you can see in Figure 22.4, the egg rests in a nest of cells called a follicle. The follicle and egg grow larger and go through other changes. 4. After a couple of weeks, the egg bursts out of the follicle and through the wall of the ovary. This is called ovulation. After ovulation occurs, the moving fingers of the nearby fallopian tube sweep the egg into the tube. Fertilization may occur if sperm reach the egg while it is 
 Question: For fertilization to take place, sperm generally must be deposited in the

Answer:
vagina.