Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.
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Question: Evolocumab met the main goal of a late-stage trial titled RUTHERFORD-2 by lowering “bad” LDL cholesterol levels when tested against a placebo on 329 patients. Amgen, the world’s biggest biotechnology company, is testing evolocumab widely on a variety of subpopulations. The RUTHERFORD-2 study included patients with familial hypercholesterolemia, an inherited condition that causes high levels of “bad” LDL cholesterol starting at birth. Specifically, patients in the study had heterozygous familial hypercholesterolemia, which is one of the most common genetic disorders affecting about one out of every 300 to 500 people worldwide, according to Amgen. The company on Tuesday reported positive results from a fourth late-stage study of evolocumab, for which it plans to begin seeking approvals this year. The drug is intended for people who cannot tolerate widely used statins, or who are unable to get their LDL levels low enough despite using high potency statins, such as AstraZeneca’s Crestor. Amgen’s shares closed at $120.89 on the Nasdaq on Thursday.

Answer: Amgen's cholesterol fighter succeeds in fifth late-stage study.


Question: Trump even suggested Thursday that the release could have been intentional. The Office of the Director of National Intelligence, the clearinghouse for the web of U.S. spy agencies, said it had ruled out the virus being man-made but was still investigating the precise source of the global pandemic, which has killed more than 220,000 people worldwide. Though scientists suggest the likeliest origin of the pandemic remains natural, that it spread from an infected animal to a human, Trump claimed to have seen evidence to support the theory that the origin was an infectious disease lab in Wuhan, the epicenter of the Chinese outbreak. He said the U.S. now “is finding how it came out.” “It’s a terrible thing that happened,” the president said. “Whether they made a mistake or whether it started off as a mistake and then they made another one, or did somebody do something on purpose.” The intel statement said the federal agencies concur “with the wide scientific consensus that the COVID-19 virus was not manmade or genetically modified.” “The IC will continue to rigorously examine emerging information and intelligence to determine whether the outbreak began through contact with infected animals or if it was the result of an accident at a laboratory in Wuhan.” In recent days the Trump administration has sharpened its rhetoric on China, accusing the geopolitical foe and vital trading partner of failing to act swiftly enough to sound the alarm about the outbreak or to stop the spread of the virus that causes COVID-19. U.S. officials have said the Chinese government should “pay a price” for its handling of the pandemic. This all comes as the pace of Trump’s own original response continues to come under scrutiny, questioned as too meager and too slow. Earlier Thursday, before Trump’s comments, the Chinese government said that any claims that the coronavirus was released from a laboratory are “unfounded and purely fabricated out of nothing.” Foreign Ministry spokesman Geng Shuang cited the institute’s director, Yuan Zhiming, as saying the lab strictly implements bio-security procedures that would prevent the release of any pathogen. “I would like to point out again that the origin of the virus is a complex scientific issue, and it should be studied by scientists and professionals,” Geng said. He also criticized those in the U.S. who say China should be held accountable for the global pandemic, saying they should spend their time on “better controlling the epidemic situation at home.” At the White House, Trump repeatedly blamed China for its handling of the outbreak, criticizing the country for restricting domestic travel to slow the virus but not international travel to keep it from spreading abroad. “Certainly it could have been stopped,” Trump said during an event in the East Room on his administration’s efforts to aid seniors during the outbreak. “They either couldn’t do it from a competence standpoint, or they let it spread.” “It got loose, let’s say, and they could have capped it.” Earlier this month, Trump addressed the lab theory saying, “More and more, we’re hearing the story.” Secretary of State Mike Pompeo added at the time, “The mere fact that we don’t know the answers — that China hasn’t shared the answers — I think is very, very telling.” Pompeo also pressed China to let outside experts into the lab “so that we can determine precisely where this virus began.” While Trump and Pompeo have made their feelings clear, a U.S. intelligence official disputed the notion that there was pressure on agencies to bolster a particular theory. The intelligence official was not authorized to publicly discuss the issue and spoke only on condition of anonymity. Scientists say the virus arose naturally in bats. Even so, Pompeo and others have pointed fingers at an institute that is run by the Chinese Academy of Sciences. It has done groundbreaking research tracing the likely origins of the SARS virus, finding new bat viruses and discovering how they could jump to people. “We know that there is the Wuhan Institute of Virology just a handful of miles away from where the wet market was,” Pompeo said two weeks ago. The institute has an address 8 miles, or 13 kilometers, from the market that is considered a possible source. U.S. officials say the American Embassy in Beijing flagged concerns about potential safety issues at the lab in Wuhan in 2018, but they have yet to find any evidence the virus originated there nearly two years later. Scientists studying the virus for months have made clear they believe it wasn’t man-made but are still working to determine a point at which it may have jumped from animals to humans. Early attention focused on the live-animal market in Wuhan where the first cases were reported in December. But the first person identified with the disease had no known connection to that market. Kristian Andersen, who studies the virus at Scripps Research in La Jolla, California, puts the odds of it being accidentally released by the Wuhan lab at “a million to one,” far less likely than an infection in nature. But virus expert David O’Connor of the University of Wisconsin-Madison said he thinks too little is known to rule out any source, except the idea the virus was man-made. Finding the source is important, he said, because it may harbor the next pandemic virus. The U.S. was providing funding to the Wuhan lab for its research on coronaviruses, Michael Morell, former acting director and deputy director of the CIA, said Thursday. He said State Department cables indicate that there have been concerns in past years among U.S. officials about the safety protocols at that lab. If the virus did escape from a Chinese lab, it not only reflects negatively on China but also on the United States for providing research funding to a lab that has safety concerns, Morell said during an online forum hosted by the Michael V. Hayden Center for Intelligence, Policy and International Security at George Mason University. “So if it did escape, we’re all in this together,” Morell said. “This is not a gotcha for China. This is a gotcha for both of us.” ___ Associated Press writers Deb Riechmann in Washington and Malcolm Ritter in New York contributed to this report.

Answer: Trump speculates that China released virus in lab ‘mistake’.


Question: The committee is also seeking the indictment of Vale and dam stability auditor TÜV SÜD for environmental damages and corporate responsibility for actions of their employees in the late-January disaster that killed nearly 250 people. The 400-page report recommended that a total of 15 individuals, including the two executives, be indicted for murder, wrongful bodily injury, environmental damages and pollution. Fabio Schvartsman stepped down as Vale’s CEO under pressure from prosecutors in March. Luciano Siani, also targeted by the committee, continues to serve as CFO. The committee’s initial report recommended manslaughter charges but at a hearing it approved an amendment to upgrade the charges to murder and add a 15th individual to its list for recommended indictments. Vale, a formerly state-owned Brazilian “national champion” which is a leading exporter and employer, said it “respectfully disagrees” with the indictment recommendations. A “forensic, technical and scientific conclusion about the causes of the dam burst” should be arrived at before holding certain people responsible, the company asserted in a statement. TÜV SÜD said it was cooperating in full but declined to comment further, citing ongoing investigations. Vale shares, which early in the session touched their highest since before the Brumadinho disaster, closed down 4.2%. The nonbinding recommendations could influence prosecutors in their ongoing probe of Vale and its executives for negligence regarding the disaster. “Vale’s tragedy is a series of tragedies,” the committee said in its report. “The immeasurable human loss; the countless dead animals; the environment destroyed for years, perhaps decades; the dreams and heritage of a lifetime buried by the carelessness, neglect, greed, usury, irresponsibility, indifference and sloppiness of a company that used to be a role model.”  Brazil must take action to ensure that “never again” will such a disaster occur, it said, recommending three laws that would require congressional approval. One would outlaw all tailings dams for mining and industrial waste. That would go far beyond a ban instituted in February on the specific type of “upstream” dam that ruptured. It would allow for 10 years to decommission the hundreds of existing tailings dams around the country, a costly move for miners. A separate bill would hike taxes calculated on mineral production, with a tax of up to 40% on more profitable or larger scale mines. The investment banking unit of Brazil’s Bradesco said such a tax is unlikely to be implemented given that comparable taxes in Australia and Mexico are up to 7.5%. But the bank said the rate is likely to rise for Brazilian miners from the current 3.5%. A third proposed law would expand the list of environmental crimes. Barclays analyst Amos Fletcher said he doubted that Congress would follow through on shutting down all types of tailings dams, a move that would halt a significant amount of mineral production, which Brazil counts on for a large portion of its GDP, he said. The recommendations may be depressing Vale’s stock price more than the indictments because of worries that such changes “would lead to more supply being squeezed,” he said. Vale’s tailings dam ruptured in the city of Brumadinho in the mining state of Minas Gerais in late January, releasing a torrent of mud that buried hundreds of people, including a cafeteria full of workers at lunchtime. In the following months, investigators and regulators pointed toward a risky “upstream” style of dam construction, improper maintenance and negligence. TÜV SÜD certified the dam as stable in 2018 despite pointing out concerns about drainage and monitoring systems. Vale has argued that it followed all the required safety measures. While authorities have yet to conclude the cause of the rupture, a Minas Gerais state official and other experts suspect liquefaction, in which solid materials such as sand lose strength and become more like liquid. That was the same cause of a 2015 rupture of another upstream Vale dam that killed 19.

Answer:
Brazil Senate panel says Vale CFO, ex-CEO should be indicted for murder.