Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
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Question: Context: A machine is any device that makes work easier by changing a force. When you use a machine, you apply force to the machine. This force is called the input force. The machine, in turn, applies force to an object. This force is called the output force. Recall that work equals force multiplied by distance: Work = Force Distance The force you apply to a machine is applied over a given distance, called the input distance. The force applied by the machine to the object is also applied over a distance, called the output distance. The output distance may or may not be the same as the input distance. Machines make work easier by increasing the amount of force that is applied, increasing the distance over which the force is applied, or changing the direction in which the force is applied. Contrary to popular belief, machines do not increase the amount of work that is done. They just change how the work is done. So if a machine increases the force applied, it must apply the force over a shorter distance. Similarly, if a machine increases the distance over which the force is applied, it must apply less force. Examples of machines that increase force are doorknobs and nutcrackers. Figure 16.8 explains how these machines work. In each case, the force applied by the user is less than the force applied by the machine, but the machine applies the force over a shorter distance. Examples of machines that increase the distance over which force is applied are paddles and hammers. Figure 16.9 explains how these machines work. In each case, the machine increases the distance over which the force is applied, but it reduces the strength of the applied force. Some machines change the direction of the force applied by the user. They may or may not also change the strength of the force or the distance over which it is applied. Two examples of machines that work in this way are claw hammers and the rope systems (pulleys) that raise or lower flags on flagpoles. Figure 16.10 explains how these machines work. In each case, the direction of the force applied by the user is reversed by the machine. How does this make it easier to do the job? An exoskeleton suit may seem like science fiction, turning ordinary humans into super heroes. But wearable robots are moving forward into reality. And for paraplegics, the ability to stand and walk that these machines provide is a super power. QUEST meets Austin Whitney and Tamara Mena, two "Exoskeleton Test Pilots" who are now putting this new technology through its paces. For more information on exoskeleton suits, see [Link] MEDIA Click image to the left or use the URL below. URL: You read above that machines do not increase the work done on an object. In other words, you cant get more work out of a machine than you put into it. In fact, machines always do less work on the object than the user does on the machine. Thats because all machines must use some of the work put into them to overcome friction. How much work? It depends on the efficiency of the machine. Efficiency is the percent of input work that becomes output work. It is a measure of how well a machine reduces friction. Consider the ramp in Figure 16.11. Its easier to push the heavy piece of furniture up the ramp to the truck than to lift it straight up off the ground. However, pushing the furniture over the surface of the ramp creates a lot of friction. Some of the force applied to moving the furniture must be used to overcome the friction. It would be more efficient to use a dolly on wheels to roll the furniture up the ramp. Thats because rolling friction is much less than sliding friction. As a result, the efficiency of the ramp would be greater with a dolly. Efficiency can be calculated with the equation: Efficiency = Output work 100% Input work Consider a machine that puts out 6000 joules of work. To produce that much work from the machine requires the user to put in 8000 joules of work. To find the efficiency of the machine, 
 Question: force applied by a machine

Answer: output force


Question: Context: Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy. We enrolled 457 patients who had active rheumatoid arthritis despite long-term methotrexate therapy in a 6-month, double-blind, placebo-controlled trial. The primary outcome was the American College of Rheumatology (ACR) 20 response (which indicates at least a 20% reduction in the number of both tender and swollen joints and improvement in at least three of five other criteria) at month 6. R788, at a dose of 100 mg twice daily and at a dose of 150 mg once daily, was significantly superior to placebo at month 6 (ACR 20 response rates of 67% and 57%, respectively, vs. 35%; P<0.001 for the comparison of both doses with placebo). It was also significantly superior with respect to ACR 50, which indicates at least a 50% improvement (43% and 32% vs. 19%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.007 for the comparison of the 150-mg dose with placebo) and ACR 70 (28% and 14% vs. 10%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.34 for the comparison of the 150-mg dose with placebo). A clinically significant effect was noted by the end of the first week of treatment. Adverse effects included diarrhea (in 19% of subjects taking the 100-mg dose of R788 vs. 3% of those taking placebo), upper respiratory infections (14% vs. 7%), and neutropenia (6% vs. 1%). R788 was associated with an increase in systolic blood pressure of approximately 3 mm Hg between baseline and month 1, as compared with a decrease of 2 mm Hg with placebo; 23% of the patients taking R788 vs. 7% of the patients receiving placebo required the initiation of or a change in antihypertensive therapy. In this phase 2 study, a Syk inhibitor reduced disease activity in patients with rheumatoid arthritis; adverse events included diarrhea, hypertension, and neutropenia. Additional studies will be needed to further assess the safety and efficacy of Syk-inhibition therapy in patients with rheumatoid arthritis. (Funded by Rigel; ClinicalTrials.gov number, NCT00665925.) 
 Question: Which enzyme is inhibited by a drug fostamatinib?

Answer: spleen tyrosine kinase


Question: Context: After a tough loss at home to the Lions, the Eagles traveled down south to New Orleans to take on the Saints in the Mercedes-Benz Superdome. The Saints scored first with Patrick Robinson returning a Michael Vick interception 99 yards for a touchdown and a 7-0 lead for the only score of the game. The Eagles got on the board in the 2nd quarter as Alex Henery kicked a 22-yard field goal to cut the lead to 7-3 not long before Chris Ivory ran for a 22-yard touchdown to move the Saints ahead by 11 with a 14-3 lead and then they would score again with Drew Brees finding Marques Coltson on a 1-yard touchdown pass for a 21-3 halftime lead. The Eagles scored 10 unanswered points in the 3rd quarter with Vick hooking up with DeSean Jackson on a 77-yard touchdown pass for a score of 21-10 and then Henery kicked a 37-yard field goal for a score of 21-13. But the Saints scored one last time as Brees found Jimmy Graham on a 6-yard touchdown pass for a 28-13 lead which would be the final score of the game as neither team scored in the 4th quarter. 
 Question: Which quarterback had 2 touchdown passes?

Answer:
drew brees