instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Hubble measured the distances to galaxies. He also studied the motions of galaxies. In doing these things, Hubble noticed a relationship. This is now called Hubbles Law: The farther away a galaxy is, the faster it is moving away from us. There was only one conclusion he could draw from this. The universe is expanding! Figure 26.15 shows a simple diagram of the expanding universe. Imagine a balloon covered with tiny dots. When you blow up the balloon, the rubber stretches. The dots slowly move away from each other as the space between them increases. In an expanding universe, the space between galaxies is expanding. We see this as the other galaxies moving away from us. We also see that galaxies farther away from us move away faster than nearby galaxies. About 13.7 billion years ago, the entire universe was packed together. Everything was squeezed into a tiny volume. Then there was an enormous explosion. After this big bang, the universe expanded rapidly (Figure 26.16). All of the matter and energy in the universe has been expanding ever since. Scientists have evidence this is how the universe formed. One piece of evidence is that we see galaxies moving away from us. If they are moving apart, they must once have been together. Also, there is energy left over from this explosion throughout the universe. The theory for the origin of the universe is called the Big Bang Theory. In the first few moments after the Big Bang, the universe was extremely hot and dense. As the universe expanded, it became less dense. It began to cool. First protons, neutrons, and electrons formed. From these particles came hydrogen. Nuclear fusion created helium atoms. Some parts of the universe had matter that was densely packed. Enormous clumps of matter were held together by gravity. Eventually this material became the gas clouds, stars, galaxies, and other structures that we see in the universe today. We see many objects out in space that emit light. This matter is contained in stars, and the stars are contained in galaxies. Scientists think that stars and galaxies make up only a small part of the matter in the universe. The rest of the matter is called dark matter. Dark matter doesnt emit light, so we cant see it. We know it is there because it affects the motion of objects around it. For example, astronomers measure how spiral galaxies rotate. The outside edges of a galaxy rotate at the same speed as parts closer to the center. This can only be explained if there is a lot more matter in the galaxy than we can see. What is dark matter? Actually, we dont really know. Dark matter could just be ordinary matter, like what makes up Earth. The universe could contain lots of objects that dont have enough mass to glow on their own. There might just be a lot of black holes. Another possibility is that the universe contains a lot of matter that is different from anything we know. If it doesnt interact much with ordinary matter, it would be very difficult or impossible to detect directly. Most scientists who study dark matter think it is a combination. Ordinary matter is part of it. That is mixed with some kind of matter that we havent discovered yet. Most scientists think that ordinary matter is less than half of the total matter in the universe. We know that the universe is expanding. Astronomers have wondered if it is expanding fast enough to escape the pull of gravity. Would the universe just expand forever? If it could not escape the pull of gravity, would it someday start to contract? This means it would eventually get squeezed together in a big crunch. This is the opposite of the Big Bang. Scientists may now have an answer. Recently, astronomers have discovered that the universe is expanding even faster than before. What is causing the expansion to accelerate? One hypothesis is that there is energy out in the universe that we cant see. Astronomers call this dark energy. We know even less about dark energy than we know about dark matter. Some scientists think that dark energy makes up
answer:
all the matter and energy that exists and all of space and time


question:
Restless legs syndrome is a neurological disorder characterized by an urgency to move the legs during periods of rest. Data from a variety of sources provide a compelling argument that the amount of iron in the brain is lower in individuals with restless legs syndrome compared with neurologically normal individuals. Moreover, a significant percentage of patients with restless legs syndrome are responsive to intravenous iron therapy. The mechanism underlying the decreased iron concentrations in restless legs syndrome brains is unknown. We hypothesize that the source of the brain iron deficit is at the blood-brain interface. Thus we analysed the expression of iron management proteins in the epithelial cells of the choroid plexus and the brain microvasculature in post-mortem tissues. The choroid plexus, obtained at autopsy, from 18 neurologically normal controls and 14 individuals who had primary restless legs syndrome was subjected to histochemical staining for iron and immunostaining for iron management proteins. Iron and heavy chain ferritin staining was reduced in the epithelial cells of choroid plexus in restless legs syndrome. Divalent metal transporter, ferroportin, transferrin and its receptor were upregulated in the choroid plexus in restless legs syndrome. Microvessels were isolated from the motor cortex of 11 restless legs syndrome and 14 control brains obtained at autopsy and quantitative immunoblot analyses was performed. Expression of heavy chain ferritin, transferrin and its receptor in the microvessels from restless legs syndrome was significantly decreased compared with the controls but divalent metal protein 1, ferroportin, prohepcidin, mitochondrial ferritin and light-chain ferritin remained unchanged. The presence of an iron regulatory protein was demonstrated in the brain microvasculature and the activity of this protein is decreased in restless legs syndrome; a finding similar to our earlier report in neuromelanin cells from the substantia nigra of restless legs syndrome brains. This study reveals that there are alterations in the iron management protein profile in restless legs syndrome compared with controls at the site of blood-brain interface suggesting fundamental differences in brain iron acquisition in individuals with restless legs syndrome. Furthermore, the decrease in transferrin receptor expression in the microvasculature in the presence of relative brain iron deficiency reported in restless legs syndrome brains may underlie the problems associated with brain iron acquisition in restless legs syndrome. The consistent finding of loss of iron regulatory protein activity in restless legs syndrome brain tissue further implicates this protein as a factor in the underlying cause of the iron deficiency in the restless legs syndrome brain. The data herein provide evidence for regulation of iron uptake and storage within brain microvessels that challenge the existing paradigm that the blood-brain barrier is merely a transport system.
answer:
Which deficiency is the cause of restless leg syndrome?


question:
La Paz F.C. plays its home matches at Estadio Hernando Siles.
answer:

Which is the stadium of La Paz F.C.?