Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

Q: Paragraph: Shares of the company traded marginally down at $132.47, after having closed up 1.7% on Monday. (bit.ly/2ZkZGze)    J&J said that the FTC had issued a “civil investigative demand,” or CID, the equivalent of a subpoena to determine if the contracting practices were legal. Pfizer Inc filed a lawsuit against J&J in 2017, saying its rival’s contracts with health insurers for blockbuster rheumatoid arthritis drug, Remicade, were anticompetitive and aimed at blocking sales of Pfizer’s biosimilar called Inflectra. Pfizer said in the lawsuit that J&J had contracted with many insurers to give discounts in exchange for giving preference to Remicade, and to only pay for Inflectra in cases where Remicade proved to be ineffective. Inflectra was approved in 2016 while Remicade went on the market in 1998. Remicade is an infused treatment for chronic autoimmune disorders and costs about $4,000 per dose, or $26,000 a year, Pfizer said in the lawsuit. J&J has denied any wrongdoing and is fighting the Pfizer lawsuit. Pfizer said in a statement that it had received a CID in June. “As Pfizer’s complaint alleges, J&J’s unlawful conduct is designed to prevent Inflectra from being able to compete on its primary point of differentiation – price. Today, Inflectra has an average selling price (ASP) that is more than 22% lower than Remicade,” the company said in a statement. “Despite these facts, J&J has not lost substantial volume or share of sales – counter to what should occur in a competitive market.”  Biosimilars are intended to be lower-cost alternatives to expensive biotech medicines. But since they are made from living cells and it is not possible to make an exact copy of the branded medicine, they are not automatically substituted for the existing branded drug the way a generic drug would be. The drugs treat ailments like rheumatoid arthritis, Crohn’s disease and ulcerative colitis. Claim: J&J says FTC probing efforts to protect arthritis drug Remicade.

A: The Federal Trade Commission issued civil subpoenas to Johnson and Johnson in June as part of an investigation into whether contracting practices for its blockbuster rheumatoid arthritis drug, Remicade, violated antitrust laws, the company said in a regulatory filing on Monday.
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Q: Paragraph: Limiting the quantity per dosage unit will reduce the risk of inadvertent overdose, which can lead to liver failure, liver transplant and death, the Food and Drug Administration said. It cited the fact that no available data showed that taking more than the recommended dose provided benefits that outweighed the added risks. (link.reuters.com/nen95v)  Inadvertent overdose from combination drugs containing acetaminophen, also known as paracetamol in most countries outside the United States, accounts for nearly half of all cases of acetaminophen-related liver failure in the United States, the agency said. Combination acetaminophen products are commonly prescribed to patients to treat pain from acute injuries, post-operative pain, or pain following dental procedures. In January 2011, the FDA asked manufacturers of combination drugs containing acetaminophen, sold globally under trade names such as Tylenol and Panadol, to limit acetaminophen doses to no more than 325 mg in each tablet or capsule by January 14, 2014. (link.reuters.com/hyn95v)  Some of these products still remain available, the agency said. The FDA also suggested that pharmacists who receive a prescription for a combination product with more than the recommended dose contact the prescriber to discuss using a lower dose. In the near future, the FDA plans to institute proceedings to withdraw approval for combination drugs that remain on the market, it said in a statement. Acetaminophen, one of the most commonly used drugs in the United States, is widely used in both prescription and over-the-counter products to reduce pain and fever. Claim: FDA asks doctors to limit acetaminophen in combination drugs.

A: U.S. health regulators recommended on Tuesday that healthcare professionals stop prescribing combination drugs that contain more than 325 milligrams of acetaminophen per tablet, capsule, or other dosage unit, citing the risk of liver damage.
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Q: Paragraph: The former Montana congressman also said he quit President Donald Trump’s cabinet on his own terms, despite indications he was pressured by the White House to resign effective Wednesday. During almost two years overseeing an agency responsible for managing 500 million acres of public lands, Zinke’s broad rollbacks of restrictions on oil and gas drilling were cheered by industry. But they brought a scathing backlash from environmental groups and Democratic lawmakers who accused him of putting corporate profits ahead of preservation. In his first interview since stepping down, Zinke said the changes he instituted meshed with Roosevelt’s belief in balance between nature and industry. He added that they were needed in part to unfetter energy companies bound by unreasonable curbs on drilling that were largely imposed under former President Barack Obama. “Teddy Roosevelt said conservation is as much development as it is preservation,” Zinke said, referencing a 1910 speech by the Republican president. “Much of our work returned the American conservation ethic to best science, best practices ... rather than an elitist view of non-management that lets nature take its course.” Zinke mentioned Roosevelt often during his almost two-year tenure, and historian Patricia Limerick said it’s accurate that the former president talked of development as a component of conservation. But Limerick noted Zinke’s recommendations to Trump to reduce the size of national monuments in the West and elsewhere was in direct contrast to Roosevelt’s embrace of the law that allowed their creation, the Antiquities Act of 1906. “You don’t get to call yourself a follower of Roosevelt if you’re really chiseling away at one of his principal heritages,” said Limerick, who chairs the board of the Center of the American West at the University of Colorado, where she’s a history professor. House Democrats plan to put Zinke’s policies under the spotlight with oversight hearings beginning next month, said Adam Sarvana, a spokesman for Rep. Raul Grijalva of Arizona, the Democrat in line to lead the House Natural Resources Committee. The hearings initially will focus on policy changes such as “giveaways” to the oil and gas industry under the leadership of Zinke, Sarvana said. He added they later could be expanded to include the various ethics investigations pending against Zinke, a former Navy SEAL and avowed Trump loyalist. The investigations have ranged from a probe into a land deal involving Zinke and the chairman of energy services giant Halliburton, to questions about his decision to reject a casino in Connecticut sought by two tribes. During his interview with the AP, Zinke denied a Washington Post report that Interior Department investigators believe he may have lied to them, which has reportedly prompted an examination of potential criminal violations by the U.S. Justice Department’s public integrity section. Several other investigations into Zinke concluded with no findings of wrongdoing. In one case he was faulted by investigators for violating a department policy by allowing his wife to ride in government vehicles with him. That report also said the Interior Department spent more than $25,000 to provide security for the couple during a vacation to Turkey and Greece. For the energy industry, Zinke brought relief from rules imposed under Obama that were meant to limit drilling in sensitive wildlife habitat, curb emissions of the greenhouse gas carbon monoxide and protect water supplies. Despite the Democrats’ newfound power in Washington after taking control of the House of Representatives, industry representatives said Zinke’s impact will be lasting. That’s because they involved agency regulations rather than congressional action and came at the order of Trump, said Dan Naatz, vice president of government relations for the Independent Petroleum Association of America. “Although Secretary Zinke was effective at what he was doing, the policy really came from the president,” Naatz said. Until Trump nominates and the Senate confirms a permanent replacement, Zinke’s shoes will be filled on an acting basis by his deputy, David Bernhardt, a former lobbyist for the oil and gas industry. Left-leaning groups that campaigned against Zinke already have turned their attention to Bernhardt with claims that his prior work leaves him compromised. “David Bernhardt is too conflicted to serve him in any position, whether it’s deputy, acting or full Interior secretary,” said Aaron Weiss with the Center for Western Priorities. Weiss also suggested the pending investigations against Zinke are likely to continue and said the former secretary “can’t make his trouble go away by simply walking away.” Wyoming Sen. John Barrasso, who chairs the Senate Environment and Public Works Committee, said Zinke worked closely with western states and respected their priorities. Barrasso said it was important for the next secretary to likewise pursue Trump’s American “energy dominance” agenda while following sound environmental practices. In his resignation letter, Zinke said he was compelled to stop down because the political attacks against him had created a distraction from Trump’s drive to boost U.S. energy production. He told the AP that the allegations fit into a “playbook” used by the administration’s critics to stifle Trump’s energy agenda, smear Zinke’s name and undercut any future bid he might make for public office. He said he won’t run for Montana governor in 2020, but did not rule out a future run. In the weeks leading up to his resignation, the White House concluded Zinke was likely the Cabinet member most vulnerable to investigations led by newly empowered Democrats in Congress, according to an administration official not authorized to publicly discuss personnel matters who spoke on condition of anonymity. In Zinke’s telling of events, Trump remained fully supportive to the end and it was the secretary himself who made the decision to go. His departure comes amid a partial government shutdown in which Zinke ordered many national parks to stay open, saying visitors shouldn’t be penalized for the political feud centered on Trump’s proposed border wall with Mexico. With reports of overflowing trash bins spurring calls for the parks to be closed until the shutdown ends, Zinke offered some parting advice as he prepared to head back to his hometown of Whitefish, Montana, just outside Glacier National Park: “I would encourage everyone that visits their parks to help pitch in, grab a trash bag and take some trash out with you,” he said. “Pack it in, pack it out.” ___ Follow Matthew Brown at https://twitter.com/matthewbrownap . Claim: Outgoing US Interior secretary defends legacy as he leaves.

A:
As former U.S. Interior Secretary Ryan Zinke exits Washington chased by ethics investigations and criticism of his actions favoring industry, he told The Associated Press he’s lived up to the conservation ideals of Theodore Roosevelt and insisted the myriad allegations against him will be proven untrue.
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