Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

[Q]: Paragraph: The analysis suggests the potentially harmful effect of Celebrex dosage is most pronounced in higher-risk patients, researchers said at the American College of Cardiology scientific meeting. “Patients at low cardiovascular risk should take some level of comfort,” said Dr. Scott Solomon, lead researcher of the National Cancer Institute-sponsored analysis. “That wasn’t so clear previously.”   Doctors should exercise caution in prescribing the drug, generally known as celecoxib, in high-risk patients, said Solomon, whose analysis was also published online in the journal Circulation. Celebrex belongs to a class of pain drugs known as cox-2 inhibitors and is the only such drug still on the market in the United States. Merck and Co Inc withdrew its widely used cox-2 drug, Vioxx, from the market in 2004 after a study showed it doubled the risk of heart attack and stroke in long- term users. Another cox-2 inhibitor from Pfizer called Bextra was also pulled from the U.S. market due to safety concerns. While the analysis sheds light on how the drug should be used, Solomon said he could not judge whether the data lift the cloud over this class of drugs. The six trials involving a total of 7,950 patients all studied Celebrex against a placebo for uses other than arthritis. Patients received either 400 milligrams once a day, 200 mg twice a day, or 400 mg twice a day. The primary goal of the pooled analysis was an assessment of the combined risk of cardiovascular death, heart attack, stroke, heart failure or events involving blood clots. Researchers found the heart risk was lowest at the 400 mg daily dose. They found nearly a two-fold risk of adverse heart events with the 200 mg twice daily dose and that jumped to about a three-fold risk at the 400 mg twice daily dose. “Even 400 mg once a day showed elevated risk” in the high-risk population, Solomon said, adding he could not extrapolate whether doses lower than 400 mg cut risk further. The increased risk was not affected by aspirin use, researchers said. “Most of the data used in this pooled analysis have previously been published and are consistent with what we already know about the cardiovascular risks of Celebrex and other prescription arthritis pain relievers,” said Gail Cawkwell, Pfizer’s executive medical director. “The analysis doesn’t provide any new conclusions on the FDA-approved doses of Celebrex, including the most commonly prescribed dose of 200 mg daily,” she said. Dr. Steven Nissen of the Cleveland Clinic, who has a study on lower doses underway, added: “There aren’t long-term randomized placebo-controlled trials for that dose, The only way we’re ever going to answer these questions is with good randomized prospective data,” he said. “We’ll tell it like it is when the data is in.” Claim: Celebrex risky in high-risk patients, study finds.
[A]: Doctors should prescribe the lowest doses of Celebrex possible in patients at high risk of heart problems, researchers who did a combined analysis of six studies of the Pfizer Inc pain drug said on Monday.


[Q]: Paragraph: "U.S. Sen. Marco Rubio used his first speech on the Senate floor, on June 14, 2011, to evoke the American dream. The so-called maiden speech is a ""big deal for a senator,"" said fellow Florida Sen. Bill Nelson — and Rubio went for big ideas. ""America is not perfect,"" said the freshman Republican, the child of Cuban immigrants. ""... But since her earliest days, America has inspired people from all over the world. Inspired them with the hope that one day their own countries would be one like this one. Many others decided they could not wait. And so they came here from everywhere, to pursue their dreams and to work to leave their children better off than themselves. And the result was the American miracle."" As he held the floor for nearly 15 minutes, Rubio highlighted rags-to-riches stories that he said happen ""only in America,"" describing the founders of Nordstrom, Mattel and eBay. When he finished, Sen. Mitch McConnell, R-Ky., commended him, saying, ""No one expresses American exceptionalism better than Sen. Rubio."" Rubio traced America’s role in the 20th century, from two world wars to the Cold War and the defeat of communism. Then he turned to other contributions:  While our military and foreign policy contributions helped save the world, it was our economic and cultural innovations that helped transform it. The fruits of the American miracle can be found in the daily lives of people everywhere. Anywhere in the world, when someone uses a mobile phone, e-mail, the Internet or GPS, they are enjoying the benefits of the American miracle. Anywhere in the world, when a bone marrow, lung or heart transplant saves a life, they are touched by the value of the American miracle. And on one night in July of 1969, the whole world witnessed the American miracle firsthand. For on that night an American walked on the surface of the moon, and it was clear to the whole world that these Americans… could do anything. We briefly considered wading into fringe conspiracy theories about whether astronauts actually walked on the moon, but got control of ourselves. We were more curious about his other technology claims. Were Americans truly the ones responsible for innovation of the mobile phone, e-mail, the Internet and the global positioning system? We dropped a line to Rubio spokesman Alex Burgos, who provided us with links about inventors of the mobile phone, e-mail, the Internet and GPS. Indeed, stories from The Telegraph (via Huffington Post), NPR, the Internet Society, PBS and MITnews identify American origins for all four technologies. But these are complex systems that have developed over time. We wondered: Was there more to the story? Mobile phone  A lot fits under the umbrella ""mobile phone"" -- including, say, early radio technology that led to car phones by the 1940s. But Rubio’s spokesman pointed to the inventor of the first portable cellular phone, which is fine by us. (Did you think of dawn-of-the-1900s ship-to-shore communication when Rubio said ""mobile phone""? We didn’t think so.) Martin Cooper worked for Illinois company Motorola as it developed the DynaTAC phone and the cellular network behind it in the early 1970s. The lead engineer for the team that developed the phone, Martin made the first wireless call from Manhattan in 1973. The FCC approved the phone -- the world’s first commercial portable cell phone -- for regular folks in 1983. Now, Japan and some European countries were quicker to deploy cellular networks, in the late ‘70s and very early ‘80s. But Paul Levinson, a Fordham University professor who wrote the 2004 book ""Cellphone: The Story of the World's Most Mobile Medium and How It Has Transformed Everything!"" says it’s the phone that matters. ""That was the breakthrough,"" he said ""There were several different companies and scientists working on it. … But no one believed that it could be done. … So everything that came afterwards was based on that first breakthrough."" An American breakthrough. Score one for Rubio. Internet & E-mail  We read the work from the Internet Society and PBS that Burgos sent our way, then exchanged messages with Stephen Stein, who teaches the history of technology at the University of Memphis. Computer networks that led to the Internet we know today include Arpanet , a 1970s project of the U.S. Department of Defense, and NSFnet, created by the National Science Foundation in the 1980s. These projects, with their indisputably American roots, provided two cornerstones of the modern-day Web: the TCP/IP protocol and a major communications backbone. But Stein pointed out that the way we interact with the Internet owes much to the work of Tim Berners-Lee, a British scientist who worked for CERN, the European Particle Physics Laboratory in Switzerland. It was there -- in the late ‘80s as NSFnet was being developed in the United States -- that Berners-Lee ""developed the whole concept of the World Wide Web,"" Stein said. (There’s more on this in a PBS article related to the one Burgos sent.) HTTP? HTML? Both Berners-Lee. ""So, yes, Americans developed the Internet, but Berners-Lee made it user-friendly,"" Stein said. Meanwhile, Virginia Tech scholar Janet Abbate says in her 1999 book ""Inventing the Internet,"" published by MIT Press, that even in the expansion of Arpanet , Americans enlisted the help of computer experts from England and France. She also points to Berners-Lee’s contributions, saying, ""The history of the Internet is not … a story of a few heroic inventors; it is a tale of collaboration and conflict among a remarkable variety of players."" The origins of e-mail, as you might expect, are entwined with the Internet. Electronic mail was part of the development of Arpanet in the early ‘70s, according to Stein, Abbate and others. American programmer Ray Tomlinson gets credit (and tongue-in-cheek blame) for the first working network mail program, picked up by users of Arpanet sites. Here's what Abbate told us when we asked her about Rubio's claim. ""I think it's an overstatement to call the Internet a purely American product. Certainly other countries were building their own computer networks (and inter-networks) in parallel with the U.S.; these other networks eventually became part of the Internet,"" Abbate said. ""Also, the Internet itself (as opposed to the earlier Apranet) was a collaborative effort with input from computer scientists in France and elsewhere, and I argue in my book that the diversity of input made the resulting system stronger. I do think the U.S. did a remarkably good job with the Internet design and expansion, maybe better than anyone else would or could have done. But if the resulting Internet hadn't suited other countries' needs, they were perfectly capable of creating their own networks (indeed, for a while there were a number of different competing network systems before TCP/IP eventually became the standard). ""And of course, the World Wide Web was invented at CERN, not in the US or by an American. So does that mean we in the U.S. are enjoying the benefits of the ""Swiss miracle"" every time we use the Web?"" GPS  The satellite technology that puts some of the smart in your smart phone and informs your car’s navigation system is a system of satellites funded by taxpayers and operated by the U.S. government. So calling the global positioning system an ""American miracle"" is no stretch. The technology was born at Aerospace Corp., a military research contractor in El Segundo, Calif. Its founding president was New York native Ivan Getting. That isn’t to say there aren’t foreign navigation satellites. The United States cooperates with Australia, China, the European Union, India, Japan and Russia on global navigation satellite systems, sometimes referred to as GNSS. But Rubio said GPS, and the history there is fairly clear -cut. The ruling  What to make of all of this? Rubio's basic point, that the technology behind mobile phones, e-mail, the Internet and GPS all have American roots, holds up. It’s true ""in a general sense,"" said Sherry Turkle, a professor at the Massachusetts Institute of Technology who writes on our relationship with technology. Or, as the University of Memphis professor, Stein, put it: ""The statement is superficially correct, but there is (as usual) more to the story."" Stein was most concerned about the non-American role in the development of the Internet, especially the substantial contribution of England's Berners-Lee. It’s also important to note in the context of Rubio’s ""only in America"" rhetoric that while the United States led, it wasn’t alone in its innovation. Other nations’ researchers contributed to the early Internet; commercial mobile phone networks were available overseas before they were in America; other nations operate satellite navigation systems. But in these areas and many others, Americans can claim primacy." Claim: Anywhere in the world, when someone uses a mobile phone, e-mail, the Internet or GPS, they are enjoying the benefits of the American miracle.
[A]: Rubio says mobile phone, e-mail, Internet, GPS stem from 'American miracle'


[Q]: Paragraph: Africa had until now largely been spared the rapid spread of COVID-19, which has infected at least 135,000 people and killed around 5,000 worldwide. Most of Africa’s reported cases were foreigners or people who had traveled abroad. Rapid testing and quarantines have been put in place to limit transmission. But concerns are growing about the continent’s ability to handle the disease. Cases have been reported in Morocco, Tunisia, Egypt, Algeria, Senegal, Togo, Cameroon, Burkina Faso, Democratic Republic of Congo, South Africa, Nigeria, Ivory Coast, Gabon, Ghana, Guinea, Sudan, Kenya and Ethiopia. Mauritania’s health ministry said late on Friday that its first coronavirus patient is a European man - nationality not specified - who had returned to Nouakchott on March 9 and had since been in quarantine. The numbers of cases in most of the countries are still in single figures. Senegal confirmed 11 new cases on Friday, raising the total in that West African nation to 21. Its health ministry said 16 had been infected by the same man who had returned from Italy. Among those confirming first cases on Friday, Kenya is the richest economy in East Africa and a hub for global companies and the United Nations, while Ethiopia is Africa’s second-most populous nation, with 109 million people. Addis Ababa and Nairobi are regional transit hubs. In Nairobi, the Kenyan authorities banned all major public events and said they would restrict foreign travel. The mayor of Addis Ababa urged citizens to avoid close personal contact but Ethiopia’s health minister said there were no plans to cancel flights. Kenyan Health Minister Mutahi Kagwe said the country’s first case, a 27-year-old Kenyan, was diagnosed on Thursday after traveling home via London on March 5. He said the government had traced most of the people she had been in contact with, including fellow passengers on her flight, and a government response team would monitor their temperatures for the next two weeks. The Ethiopian case was a 48-year old Japanese national who arrived in Ethiopia on March 4, the health ministry said. Guinea’s first case was an employee of the European Union delegation who had self-isolated after she felt ill upon returning from Europe, the EU delegation said. Sudan’s first confirmed coronavirus case was a man who died on Thursday in the Sudanese capital Khartoum, the Health Ministry said. He had visited the United Arab Emirates in the first week of March. Kenyan Health Minister Mutahi Kagwe said the government had suspended all public gatherings, sporting events, open-air religious meetings and events “of a huge public nature”. Schools will remain open but inter-school events were suspended. Public transport operators must install hand sanitizers in their vehicles and clean them regularly, Kagwe said, while foreign travel would be restricted. Soon after the announcement, shoppers in one Nairobi supermarket were buying up cart loads of staples such as maize flour and water, as well as hand sanitizers and soap. Kenya Airways suspended flights to China last month and on Thursday added Rome and Geneva to the list of suspended destinations. Kenya, which relies heavily on Asian imports, has seen disruptions to its supply chain and a decline in tourism, an important source of hard currency and jobs. “We are going to be hit badly,” Tourism Minister Najib Balala told journalists. The Nairobi Securities Exchange halted trading in the afternoon after the main NSE 20 share index   dropped by more than 5% following the news. Mauritius, an island nation off the coast of East Africa whose economy depends on tourism and financial services, has yet to report any COVID-19 cases but said it was offering liquidity to banks to support struggling firms hit by the impact of the virus and cutting banks’ cash reserve requirements. Claim: Kenya, Ethiopia join expanding list of African states with coronavirus.
[A]:
Kenya, Ethiopia, Sudan, Guinea and Mauritania all confirmed their first cases of the new coronavirus on Friday, giving the disease a foothold in 19 countries on the African continent.