Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Input: Consider Input: Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.

Output: adverse drug event


Input: Consider Input: Short cardiopulmonary resuscitation restored spontaneous circulation and the patient recovered completely.

Output: non-adverse drug event


Input: Consider Input: Myoglobinuria and acute renal failure associated with intravenous vasopressin infusion.


Output: adverse drug event