Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

Ex Input:
Paragraph: The analysis suggests the potentially harmful effect of Celebrex dosage is most pronounced in higher-risk patients, researchers said at the American College of Cardiology scientific meeting. “Patients at low cardiovascular risk should take some level of comfort,” said Dr. Scott Solomon, lead researcher of the National Cancer Institute-sponsored analysis. “That wasn’t so clear previously.”   Doctors should exercise caution in prescribing the drug, generally known as celecoxib, in high-risk patients, said Solomon, whose analysis was also published online in the journal Circulation. Celebrex belongs to a class of pain drugs known as cox-2 inhibitors and is the only such drug still on the market in the United States. Merck and Co Inc withdrew its widely used cox-2 drug, Vioxx, from the market in 2004 after a study showed it doubled the risk of heart attack and stroke in long- term users. Another cox-2 inhibitor from Pfizer called Bextra was also pulled from the U.S. market due to safety concerns. While the analysis sheds light on how the drug should be used, Solomon said he could not judge whether the data lift the cloud over this class of drugs. The six trials involving a total of 7,950 patients all studied Celebrex against a placebo for uses other than arthritis. Patients received either 400 milligrams once a day, 200 mg twice a day, or 400 mg twice a day. The primary goal of the pooled analysis was an assessment of the combined risk of cardiovascular death, heart attack, stroke, heart failure or events involving blood clots. Researchers found the heart risk was lowest at the 400 mg daily dose. They found nearly a two-fold risk of adverse heart events with the 200 mg twice daily dose and that jumped to about a three-fold risk at the 400 mg twice daily dose. “Even 400 mg once a day showed elevated risk” in the high-risk population, Solomon said, adding he could not extrapolate whether doses lower than 400 mg cut risk further. The increased risk was not affected by aspirin use, researchers said. “Most of the data used in this pooled analysis have previously been published and are consistent with what we already know about the cardiovascular risks of Celebrex and other prescription arthritis pain relievers,” said Gail Cawkwell, Pfizer’s executive medical director. “The analysis doesn’t provide any new conclusions on the FDA-approved doses of Celebrex, including the most commonly prescribed dose of 200 mg daily,” she said. Dr. Steven Nissen of the Cleveland Clinic, who has a study on lower doses underway, added: “There aren’t long-term randomized placebo-controlled trials for that dose, The only way we’re ever going to answer these questions is with good randomized prospective data,” he said. “We’ll tell it like it is when the data is in.” Claim: Celebrex risky in high-risk patients, study finds.

Ex Output:
Doctors should prescribe the lowest doses of Celebrex possible in patients at high risk of heart problems, researchers who did a combined analysis of six studies of the Pfizer Inc pain drug said on Monday.


Ex Input:
Paragraph: Boise television station KTVB reports that Idaho residents fighting serious diseases like lymphoma, multiple myeloma and leukemia previously had to leave the state to get the potentially life-saving treatment, which involves transplanting stem cells or bone marrow from a donor into the patient’s body. On Thursday doctors at St. Luke’s Mountain States Tumor Institute in Boise performed the procedure on Patricia Edwards to treat her myeloid leukemia. Edwards was diagnosed in January and told that an allogeneic transplant was the best option. “I said, ‘What are my chances without going this route?’ And (my doctor) said four to six months,” Edwards said. Edwards was happy she didn’t need to travel out of state for the highly complicated procedure. “One of the things that bothered me the most was that I’d have to be there for three months. And I’m a homebody so I like to be home” she said. Edwards’ sister was a perfect match and donated her stem cells. The treatment means staying in the hospital for a month, followed by months more of recovery and treatment. “If it saves my life, it’s well worth it, isn’t it?” Edwards said. Dr. Finn Petersen joined St. Luke’s from Utah as the new MSTI Blood and Transplant Program director. “I think she’s done really well,” Petersen, said. He says the procedure is typically available only at university hospitals because it’s so complicated; the patient is getting a whole new immune system. “Where the trick then is to get this new healthy donor immune system to fight the patient’s cancer,” he said. “We are more and more coming to the understanding that the key to curing the patient is to get the donor immune cells to do the job.” ___ Information from: KTVB-TV, http://www.ktvb.com/ Claim: Boise woman receives first allogeneic transplant in Idaho.

Ex Output:
Doctors have performed Idaho’s first allogeneic stem cell transplant.


Ex Input:
Paragraph: "The sight of the moon’s shadow passing directly in front of the sun, blotting out all but the halo-like solar corona, may draw the largest live audience for a celestial event in human history. When those watching via broadcast and online media are factored into the mix, the spectacle will likely smash records. “It will certainly be the most observed total eclipse in history,” astronomer Rick Fienberg of the American Astronomical Society (AAS) said last week. The eclipse begins its cross-country trajectory over the Pacific Coast of Oregon in late morning. It will reach South Carolina’s Atlantic shore some 90 minutes later. The total eclipse of the sun is considered one of the most spell-binding phenomena in nature but it rarely occurs over a wide swath of land, let alone one of the world’s most heavily populated countries at the height of summer. In terms of audience potential, it is hard to top the United States, with its mobile and affluent population, even though the direct path is mostly over rural areas, towns and small cities. The largest is Nashville, Tennessee, a city of 660,000 residents. Even so the advent of social media and inexpensive high-tech optics have boosted public awareness, assuring what many U.S. experts predict will be unprecedented viewership for the so-called “Great American Eclipse.”   Some might take issue with that prediction, citing a solar eclipse visible over parts of India, Nepal, Bangladesh and central China in July 2009. National Geographic estimated 30 million people in Shanghai and Hangzhou alone were in its path that day. On Monday, the deepest part of the shadow, or umbra, cast by the moon will fall over a 70-mile-wide (113-km-wide), 2,500-mile-long (4,000-km-long) ""path of totality"" traversing 14 states. The 12 million people who live there can view the eclipse at its fullest merely by walking outside and looking up, weather permitting. (tmsnrt.rs/2fNQHFb)  LIVESTREAMING AND PRICE-GOUGING  Some 200 million Americans reside within a day’s drive of the totality zone, and as many as 7 million, experts say, are expected to converge on towns and campgrounds along the narrow corridor for the event. Many are attending multiday festivals featuring music, yoga and astronomy lectures. Millions more could potentially watch in real time as the eclipse is captured by video cameras mounted on 50 high-altitude balloons and streamed online in a joint project between NASA and Montana State University. A partial eclipse will appear throughout North America. Adding further to the excitement is the wide availability of affordable solar-safe sunglasses produced by the millions and selling so fast that suppliers were running out of stock. The owner of one leading manufacturer reported price gouging by second-hand dealers who were buying up large supplies and reselling them over the internet at a huge mark-up. Not all the hoopla will unfold on dry land. Welsh pop singer Bonnie Tyler is slated to perform her 1983s hit single “Total Eclipse of the Heart” aboard a cruise liner as the vessel sails into the path of totality from Florida on Monday. Back on the ground, forest rangers, police and city managers in the total eclipse zone are bracing for a crush of travelers they fear will cause epic traffic jams and heighten wildfire hazards. “Imagine 20 Woodstock festivals occurring simultaneously across the nation,” Michael Zeiler, an AAS advisory panel member wrote on his website, GreatAmericanEclipse.com, referring to the famously chaotic 1969 outdoor rock extravaganza in upstate New York. Hundreds of residents in a prime-viewing area in Oregon had to evacuate on Saturday under threat from a wildfire raging in the Deschutes National Forest, according to InciWeb fire-tracking website. The so-called Milli Fire, which has scorched more than 7,8OO acres (3,162 hectare), is one of seven burning in Oregon, Montana and Idaho, three of the states crossed by the totality path. Zeiler, an avowed “eclipse chaser” who made the 650-mile (1,046-km) drive from his New Mexico home to Wyoming for a choice view, said South Carolina is likely to see the greatest influx as the destination state closest to the entire U.S. Eastern seaboard. Monday’s event will be the first total solar eclipse spanning the entire continental United States since 1918 and the first visible anywhere in the Lower 48 states in 38 years. The next one over North America is due in just seven years, in April 2024." Claim: Millions of Americans to gaze upon Monday's once-in-a-lifetime eclipse.

Ex Output:

Twilight will fall at midday on Monday, stars will glimmer and birds will roost in an eerie stillness as millions of Americans and visitors witness the first total solar eclipse to traverse the United States from coast to coast in 99 years.