Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.

[EX Q]: Luke Miels, who joined GSK in September 2017 after a contract dispute with his former employer AstraZeneca, said picking the most promising projects and developing them quickly now takes precedence over spreading the risk of failure. “In the past, 10 programs were chosen, a budget for eight was allocated. Usually what happened was that time was the trade off that was made,” he said in an interview. “Now what we do is we pick five or six programs, and concentrate investment there.”   GSK, like rivals, was in the habit of testing new drugs first on patients who had run out of other treatment options. If successful, it would try patients at an earlier stage of their disease, replacing older, established treatments. In today’s market, where rivals in the United States and China catch up fast if a new class of drug shows promise, GSK has to run costly drug tests on humans in several settings at the same time, even if it means dropping other drug candidates. “Rather than do things sequentially, you do them in parallel, or as close to parallel as possible,” Miels said. GSK, which is battling to return to profit growth, has taken this approach for instance with an experimental drug that for now goes by the code name of GSK’916 against multiple myeloma, a common and incurable type of blood cancer. Likewise, GSK doubled down on its quest to bring a drug known as GSK’165 to market as a rheumatoid arthritis treatment, even after initial results in a mid-stage drug trial did not show a clear enough reading. “This drug has very interesting effects on pain. That could potentially reduce the use of opioids and pain meds,” Miels said. More trials will be run to make the pain argument more clearly, he added. GSK expects a decline of 5%-9% in adjusted earnings per share this year, excluding exchange rate moves, as it suffers from generic competition to its inhalable lung drug Advair and pressure from rival Gilead in HIV treatments. Miels said a tougher stance on drug prices by U.S. lawmakers and medical insurers was one of the reasons for the need for speed in bringing drugs to market - to try to remain ahead of competitors for as long as possible. At the same time, rapid growth in the Chinese market was spurring a more sophisticated healthcare system there, with local biotech groups quick to catch up with Western pioneers in drug development, producing similar drugs for their home market.
[EX A]: GSK pharma head flags need for speed in high-pressure drug market.

[EX Q]: On 10 May 1991, a 14-year-old Boy Scout named David Hahn earned an Atomic Energy merit badge, the first (and likely only) person in the history of Troop 371 in Clinton Township, Michigan, to receive a badge in that discipline: David was awarded his Atomic Energy merit badge on May 10, 1991, five months shy of his fifteenth birthday. To earn it he made a drawing showing how nuclear fission occurs, visited a hospital radiology unit to learn about the medical uses of radioisotopes and built a model reactor using a juice can, coat hangers, soda straws, kitchen matches, and rubber bands. By now, though, David had far grander ambitions. Throughout his childhood, Hahn had been obsessed with chemistry, teaching himself everything he knew from encyclopedias, textbooks, and chemistry sets, while personal safety did not seem to be a concern of his. According to a 1998 Harper’s profile of Hahn written by Ken Silverstein, “He once appeared at a scout meeting with a bright orange face caused by an overdose of canthaxanthin, which he was taking to test methods of artificial tanning.” In another instance, he was held responsible for a blowing a large hole in the wall of a Boy Scout tent after accidentally igniting a stockpile of powdered magnesium he had brought along. His “laboratory” was eventually moved to the potting shed behind his mother’s house, after an incident in his father’s basement that did not go as planned: One night as [Hahn’s father and stepmother] were sitting in the living room watching TV, the house was rocked by an explosion in the basement. There they found David lying semiconscious on the floor, his eyebrows smoking. Unaware that red phosphorus is pyrophoric, David had been pounding it with a screwdriver and ignited it. After achieving the rank of Eagle Scout, Hahn decided he wanted to experiment with real radioactivity, not merely the models he had used to earn his badge. He created various radioactive devices, including two different “neutron guns” that emitted radioactive particles, and eventually decided he wanted to create a “breeder reactor” — an energy generating nuclear reactor that actually produces more fissile material than it consumes (by essentially turning material around it radioactive). The concept was popular in the 1970s but for the most part has been abandoned thanks to modern technology and geologic finds that make mining uranium more cost-efficient. The breeder reactor concept was described by the Department of Energy in 1971 as follows: A breeder is a reactor that produces more fuel than it consumes … If the breeder can be used in a nuclear power plant, it can provide the heat needed for the generation of electricity and simultaneously produce an excess of fissionable material that can be used to fuel other plants. The answer to this apparent contradiction is that breeder reactors do not give “something for nothing”, but produce usable fissionable material from comparatively useless fertile material at a greater rate than the original fuel in the reactor is consumed in the fissioning process. The obvious question is how would an adolescent working out of his mother’s potting shed acquire fissile material to play around with? This is where Hahn’s myopic focus and determination really shined: Many household products (and even more in the 1990s) contain radioactive material, but the problem is scale. Hahn exploited several commonly found products and used his knowledge of chemistry to extract and concentrate it to create radioactivity at levels “not found in nature.” Early on, one common source of Hahn’s radioactive material came from household smoke detectors, which contain extremely small amounts of the radioactive isotope americium-241 as part of the mechanism that detects smoke. He “contacted smoke-detector companies and claimed that he needed a large number of the devices for a school project.” To obtain the radioactive isotope thorium-232, Hahn recalled a fact he had learned as an Eagle Scout: that the mantle of gas lanterns contains traces of the radioactive material. So he purchased “thousands of lantern mantles from surplus stores and, using the blowtorch, reduced them into a pile of ash.” This method produced radiation levels “9,000 times the level found in nature and 170 times the level that requires [Nuclear Regulatory Commission] licensing.” Radium-226, he learned, was found in the paint of antique luminescent clocks. Hahn was able to find an antique can of the mildly radioactive paint in a clock at a nearby antique store, which he used to isolate the isotope for experiments. Tritium, he found, was used as a component of glow-in-the-dark gun and bow sights, which he repeatedly purchased and returned as part of a scheme to collect the material. Hahn “removed the tritium contained in a waxy substance inside the sights, and then, using a variety of pseudonyms, returned the sights to the store or manufacturer for repair—each time collecting another tiny quantity of tritium.” These purchases were not the only instances in which Hahn employed subterfuge to obtain radioactive material. Claiming to be a professor, he once wrote to a Czechoslovakian firm that sells uranium to commercial and university buyers, obtaining a few samples of material which contained uranium-235 and uranium-238. “Ignoring any thought of safety,” as Harper’s described it, he attempted to build a reactor using the radioactive material he had collected over the years, using a schematic in his father’s college chemistry textbook as his guide: [Hahn] took the highly radioactive radium and americium out of their respective lead casings and, after another round of filing and pulverizing, mixed those isotopes with beryllium and aluminum shavings, all of which he wrapped in aluminum foil. What were once the neutron sources for his guns became a makeshift “core” for his reactor. He surrounded this radioactive ball with a “blanket” composed of tiny foil-wrapped cubes of thorium ash and uranium powder, which were stacked in an alternating pattern with carbon cubes and tenuously held together with duct tape. While he never achieved the critical mass necessary for a self-sustaining reaction, Hahn certainly appeared to have accomplished the creation of some new fissile material: [Hahn] monitored his “breeder reactor” … with his Geiger counter. “It was radioactive as heck,” he says. “The level of radiation after a few weeks was far greater than it was at the time of assembly. I know I transformed some radioactive materials. Even though there was no critical pile, I know that some of the reactions that go on in a breeder reactor went on to a minute extent” … When his Geiger counter began picking up radiation five doors down from his mom’s house, David decided that he had “too much radioactive stuff in one place” and began to disassemble the reactor. He placed the thorium pellets in a shoebox that he hid in his mother’s house, left the radium and americium in the shed, and packed most of the rest of his equipment into the trunk of the Pontiac 6000. All of these events took place before the end of 1994, and perhaps they would have remained a secret to this day if Hahn had not stashed the remains of his nuclear reactor in that Pontiac. On 31 August 1994, police responded to complaints that Hahn was in a residential neighborhood “stealing tires from a car.” In their discussion with Hahn, the police ended up performing a search of the car and found: When they opened the trunk they discovered a toolbox shut with a padlock and sealed with duct tape for good measure. The trunk also contained over fifty foil-wrapped cubes of mysterious gray powder, small disks and cylindrical metal objects, lantern mantles, mercury switches, a clock face, ores, fireworks, vacuum tubes, and assorted chemicals and acids. The police were especially alarmed by the toolbox, which David warned them was radioactive and which they feared was an atomic bomb. The discovery of the radioactive contents of Hahn’s trunk “automatically triggered the Federal Radiological Emergency Response Plan, and state officials soon were embroiled in tense phone consultations with the DOE, EPA, FBI, and NRC.” After examining his mother’s property (which she had cleansed of the most radioactive material in advance of law enforcement searches of the property for fear she would lose her home), authorities decided that the site was to be an EPA clean-up operation: A Superfund cleanup took place between June 26 and 28 at a cost of about $60,000. After the moon-suited workers dismantled the potting shed with electric saws, they loaded the remains into thirty-nine sealed barrels placed aboard a semitrailer bound for Envirocare, a dump facility located in the middle of the Great Salt Lake Desert. There, the remains of [Hahn’s] experiments were entombed along with tons of low-level radioactive debris from the government’s atomic-bomb factories, plutonium-production facilities, and contaminated industrial sites. Hahn fell into a deep depression following this episode, according to Harper’s, which was likely exacerbated by his mother’s suicide in 1996. He enlisted in the armed forces and spent four years in the U.S. Navy followed by some time in the Marines Corps before returning to his home state of Michigan. In 2007 the FBI investigated claims that Hahn was storing radioactive material in his apartment. In an interview with the FBI, Hahn described his honorable discharge from the military and his struggles with paranoid schizophrenia in the years following his return home: Hahn advised that prior to joining the Navy in May, 1997, he got into trouble for stealing tires and rims from a vehicle. Hahn stated he was in the Navy for approximately five and a half years as a internal communication specialist as well as various other positions. Hahn said he then received his associates from Macomb Community College for Applied Science in Criminal Justice. Hahn advised that he then enlisted in the Marines in 2004. Hahn stated he was a truck driver for approximately a year and a half before he was honorably discharged. Hahn said after a few months living with his [REDACTED], Hahn moved to his current residence. Hahn advised that he does not currently have a job. Hahn stated he is on disability because he was diagnosed with paranoid schizophrenia. Hahn said he also has radiation poisoning from his prior contact with radioactive substances. Hahn advised that he is compliant with all his medications most of the time. Hahn stated he occasionally drinks while he is on his medications. Hahn ran into trouble with the law for stealing smoke detectors in 2007 as well, and he experienced repeated drug-related incidents in the years following. He died on 27 September 2016 at the age of 39, a death which was the result of alcohol poisoning, his father said: Citing a toxicology and autopsy report, Kenneth Hahn said his son was found with a dangerous level of blood alcohol content, 0.404, late in the evening on September 26, 2016 … Prior to his death, [Kenneth] Hahn accompanied his son to the Veterans Administration hospital for quarterly routine checkups. Medical staff there found no lingering ill effects from the earlier radiation exposure.
[EX A]: In 1994, a 17-year-old Eagle Scout built a nuclear reactor in his mother’s backyard, an act that ultimately necessitated a Superfund cleanup.

[EX Q]: Despite being used both recreationally and medicinally for millennia, the mechanisms by which cannabis affects the human body have only recently come to light. The most significant development in this body of work is the discovery of what scientists term the “endocannabinoid system,” a collection of chemical pathways found in mammals whose existence wasn’t demonstrated until the 1990s. The endocannabinoid system is made up of specific receptors that are primarily affected by chemicals already in your body — endocannabinoids. As it turns out, many of the chemicals in cannabis, termed “phytocannabinoids”, are nearly identical to the endocannabinoids already present and can therefore also affect these receptors as well if they make their way into your bloodstream. The most famous of these chemicals is tetrahydrocannabinol (commonly known as THC), which produces the psychoactive “high” people seek when they use the drug recreationally. Later research has yielded the discovery of a plethora of other phytocannabinoids that do not produce a psychoactive effect, but do demonstrate therapeutic potential. The most notable of these “other” chemicals is cannabidiol (referred to as CBD), which studies suggest has strong pain-relieving and anti-inflammatory properties, and has been shown essentially to halt seizures caused by the neurologic condition Dravet’s Syndrome. A 2008 paper published in Proceedings of the National Academy of Sciences suggested that CBD acted on a previously undescribed endocannabinoid receptor, GPR55, and that this receptor likely plays a role in the regulation of bone mass by inhibiting the growth of cells — osteoclasts — that promote the resorption of bone minerals: Our observations also suggest that CBD can inhibit bone resorption in vivo via modulation of GPR55 signaling. They go on to suggest, however, that because THC has the opposite effect on this receptor, that this interaction may negate the positive effects on bone density caused by CBD: Our observations suggest that blocking GPR55 also may have direct beneficial effects on bone turnover in arthritic or metabolic bone diseases. Finally, although CBD is a major constituent of cannabis, it remains to be determined whether cannabis smoking may increase bone density, because [THC], another constituent, also is thought to be a GPR55 ligand and may oppose the effects of CBD. In this context, two studies took a closer look at the possible mechanisms by which CBD, specifically, might help bones heal from a fracture. A 2014 study published in Biochemical Pharmacology that utilized isolated cells suggested that CBD may activate a receptor in the endocannabinoid system (CB2) that enhances the migration of mesenchymal stem cells (which play a role in creating calcified bones) to the site of the fracture. A 2015 study published in the Journal of Bone and Mineral Research reaffirmed the possibility that CBD can help with healing fractures: Here we report that the major non-psychoactive cannabis constituent, cannabidiol (CBD), enhances the biomechanical properties of healing rat mid-femoral fractures. The maximal load and work-to-failure, but not the stiffness, of femurs from rats given a mixture of CBD and Δ9-tetrahydrocannabinol (THC) for 8 weeks were markedly increased by CBD. They found that, indeed, CBD increased the strength of the healed broken femurs of laboratory rats. The authors noted that CBD, with all other constituents removed, was more effective. They suggest a different mechanism for this effect: CBD increases the expression of a gene that codes for a series of reactions that results in the production of collagen, which is then transformed into harder bone material, a process termed collagen cross-linking. Each of these three mechanisms that link CBD to bone physiology has support in the scientific community, as attested to by their inclusion in a September 2016 review of phytocannabinoid pharmacology in the journal Physiological Reviews. It is important to note, however, that CBD specifically, and not the cannabis plant as a whole, is implicated in the therapeutic effects on bones. As such, consuming just any cannabis would not necessarily be effective. Any treatment would require an effort to isolate or increase the concentration of CBD and remove or reduce THC.
[EX A]:
Scientific studies support the conclusion that marijuana can play a role in healing broken bones.