Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Ex Input:
Although radiation-induced laryngeal necrosis has become a rare complication, the combination of chemotherapy and radiation therapy may increase its incidence.

Ex Output:
non-adverse drug event


Ex Input:
A complete immunohistochemical study was performed on heart specimens.

Ex Output:
non-adverse drug event


Ex Input:
Approximately 5-6% of intravaginal clindamycin is absorbed in the bloodstream, making systemic effects possible.

Ex Output:

non-adverse drug event