instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Mowat-Wilson syndrome is a genetic condition characterized by a recognizable facial phenotype in addition to moderate to severe cognitive disability with severe speech impairment and variable multiple congenital anomalies. The anomalies may include Hirschsprung disease, heart defects, structural eye anomalies including microphthalmia, agenesis of the corpus callosum, and urogenital anomalies. Microcephaly, seizure disorder and constipation are common. All typical cases result from haploinsufficiency of the ZEB2 (also known as ZFHX1B or SIP-1) gene, with over 100 distinct mutations now described. Approximately 80% of patients have a nonsense or frameshift mutation detectable by sequencing, with the rest having gross deletions necessitating a dosage sensitive assay. Here we report on the results of comprehensive molecular testing for 27 patients testing positive for MWS. Twenty-one patients had a nonsense, frameshift, or splice site mutation identified by sequencing; 14 of which localized to exon 8 and 17 of which are novel. Six patients had deletions in the ZEB2 gene, including two novel partial gene deletions. This report, the first such analysis in North American patients, adds to the growing list of both novel pathogenic mutations associated with MWS, as well as other variants in the ZEB2 gene. In addition, we suggest an economical testing strategy.
answer:
Which gene is responsible for the development of the Mowat-Wilson syndrome?


question:
Lighter and cheaper than high-quality video cameras, today's best smartphones can shoot and edit high-definition (HD) videos. With lower-quality lenses and image sensors, smartphones probably won't replace professional video cameras anytime soon. Still, some creative filmmakers are extending the borders of smartphone moviemaking by shooting professional-quality films using only smartphones. Soon after Apple's iPhone 4 was released, two filmmakers decided to make a short film using only their iPhone 4s. Michael Koerbel and Anna Elizabeth James shot and edited the one-and-a-half-minute film Apple of My Eye in only 48 hours. Audiences were fascinated with the film, in which a man and his grandfather connect emotionally while admiring a model train set in a store window. The filmmakers followed up their success with Goldilocks, an extraordinary spy novel told over nine, three-minute films. Many filmmakers are convinced that smartphone films are here to stay. One sign is their inclusion in major film festivals. In February 2012, organizers of the Berkshire International Film Festival staged the 10 X 10 On North Festival. Entries included Oliver by Hooman Khalili, an award-winning film about a girl whose special powers enable her to brighten the lives of three lonely people. Another entry was Yearlapse'11, a 365-second film by Zsolt Haraszti that describes an actual journey he made from New York to London. During the festival, which ran from February 16 to 26, these and many other smartphone films were shown at the Beacon Cinema in Pittsfield, Massachusetts. Similar festivals in Canada and South Korea have given smartphone filmmakers opportunities to show off their creative work.
answer:
Which film is about secret agents?


question:
Children with chromosome 22q11.2 deletion syndrome (22q11.2DS), Fragile X syndrome (FXS), or Turner syndrome (TS) are considered to belong to distinct genetic groups, as each disorder is caused by separate genetic alterations. Even so, they have similar cognitive and behavioral dysfunctions, particularly in visuospatial and numerical abilities. To assess evidence for common underlying neural microstructural alterations, we set out to determine whether these groups have partially overlapping white matter abnormalities, relative to typically developing controls. We scanned 101 female children between 7 and 14years old: 25 with 22q11.2DS, 18 with FXS, 17 with TS, and 41 aged-matched controls using diffusion tensor imaging (DTI). Anisotropy and diffusivity measures were calculated and all brain scans were nonlinearly aligned to population and site-specific templates. We performed voxel-based statistical comparisons of the DTI-derived metrics between each disease group and the controls, while adjusting for age. Girls with 22q11.2DS showed lower fractional anisotropy (FA) than controls in the association fibers of the superior and inferior longitudinal fasciculi, the splenium of the corpus callosum, and the corticospinal tract. FA was abnormally lower in girls with FXS in the posterior limbs of the internal capsule, posterior thalami, and precentral gyrus. Girls with TS had lower FA in the inferior longitudinal fasciculus, right internal capsule and left cerebellar peduncle. Partially overlapping neurodevelopmental anomalies were detected in all three neurogenetic disorders. Altered white matter integrity in the superior and inferior longitudinal fasciculi and thalamic to frontal tracts may contribute to the behavioral characteristics of all of these disorders.
answer:

What chromosome is affected in Turner's syndrome?