Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Is it time to kick Russia out of the BRICs ? If so, it may end up sounding like a famous ball-point pen maker-BIC. An argument is being made that Goldman Sach's famous marketing device ,the BRICs, should really be the BICs. "Is Russia really worth the name BRICs?" asks Anders Aslund, senior fellow at the Peterson Institute for International Economics, in an article for Foreigh Policy. Aslund, who is also co-author with Andrew Kuchins of "The Russian Balance Sheet", thinks the Russia of Putin and Medvedev is just not worthy of inclusion alongside Brazil, India and China in the list of future economic powerhouses. He writes: "The country's economic performance has fallen to such a weak level that one must ask whether it has any say at all on the global economy, compared with the other members of its group. I have just returned from Moscow, which is always dull around this season. For the last seven years, Russia has taken very few measures to improve its economy. Instead, the state has been living on oil and gas. " Economically, Aslund has the numbers on his side. The International Monetary Fund figures that the Russian economy will fall by 6.7 percent in 2009, while China will grow 8.5 percent and India 5.4 percent. There is less of a case for Brazil, with a fall of 0.7 percent, but it is still doing far better than Russia. But the BRICs are not just about economy. As is mentioned above, it is a marketing device to encourage investors to focus on the big promising players. From an investment standpoint, it could be argued that Russia is leading the BRICs. Its stock market is up 128 percent this year while around 80 percent is for the other three. At very least, however, Russia's economic underperformance and stock market outperfoumance does suggest it is indeed one of the group.

Answer: According to the passage, which country will enjoy the biggest increase in 2009?


Question: The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein tau. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds tau with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the tau-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10(-9) M MAP2c and 10(-8) M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and tau might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease.

Answer: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?


Question: During the 1920s, specifically In 1928, the components of the Dow were increased to 30 stocks near the economic height of that decade, which was nicknamed the Roaring Twenties. This period downplayed the influence of an early Depression of 192021 plus certain international conflicts such as the Polish-Soviet war, the Irish Civil War, the Turkish War of Independence and the initial phase of the Chinese Civil War. The Wall Street Crash of 1929 and the ensuing Great Depression over the next several years returned the average to its starting point, almost 90% below its peak. By July 8, 1932, following its intra-day low of 40.56, the Dow would end up closing the session at 41.22. The high of 381.17 on September 3, 1929, would not be surpassed until 1954, in inflation-adjusted numbers. However, the bottom of the 1929 Crash came just 2 months later on November 13, 1929, when intra-day it was at the 195.35 level, closing slightly higher at 198.69. For the decade, the Dow would end off with a healthy 131.7% gain, from 107.23 points at the beginning of 1920, to a level of 248.48 points at the end of 1929, just before the Crash of 1929.

Answer:
Which years of the Roaring Twenties were actually a depression?