Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
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Question: Successful treatment with partial resection of the posterior mitral valve leaflet and antibiotic therapy with cefazolin.

Answer: non-adverse drug event


Question: Sweet's syndrome associated with sargramostim (granulocyte-macrophage colony stimulating factor) treatment.

Answer: adverse drug event


Question: Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.

Answer:
adverse drug event