Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: Lewy bodies and coarse Lewy neurites are the pathological hallmarks of degenerating neurons in the brains of patients suffering from Parkinson's disease (PD). Recently, the presynaptic protein alpha-synuclein was shown to be a major component of Lewy bodies and Lewy neurites. This study demonstrates for the first time that extensive and thin alpha-synuclein-immunoreactive inclusions are present in the axonal processes of neurons.
Example Output: Which is the primary protein component of Lewy bodies?

Example Input: With an ageing population and improving cancer therapies, the two most common benign and malignant bone diseases, osteoporosis and bone metastases, will continue to affect an increasing number of patients. Our expanding knowledge of the molecular processes underlying these conditions has resulted in novel bone targets that are currently being explored in clinical trials. Clearly, the approval of denosumab, a monoclonal antibody directed against RANKL, has just marked the beginning of a new era for bone therapy with several additional new therapies lining up for clinical approval in the coming years. Potential agents targeting the osteoclast include cathepsin K, currently in phase 3 trials, and src inhibitors. Amongst anabolic agents, inhibitors of the Wnt-inhibitor sclerostin and dickkopf-1 are promising in clinical trials. Here, we will provide a comprehensive overview of the most promising agents currently explored for the treatment of bone diseases.
Example Output: To the ligand of which receptors does Denosumab (Prolia) bind?

Example Input: Work is defined differently in physics than in everyday language. In physics, work means the use of force to move an object. The teens who are playing basketball in the picture above are using force to move their bodies and the basketball, so they are doing work. The teen who is studying isnt moving anything, so she isnt doing work. Not all force that is used to move an object does work. For work to be done, the force must be applied in the same direction that the object moves. If a force is applied in a different direction than the object moves, no work is done. The Figure 1.1 illustrates this point. Q: If the box the man is carrying is very heavy, does he do any work as he walks across the room with it? A: Regardless of the weight of the box, the man does no work on it as he holds it while walking across the room. However, he does more work when he first lifts a heavier box to chest height. Work is directly related to both the force applied to an object and the distance the object moves. It can be represented by the equation: Work = Force Distance This equation shows that the greater the force that is used to move an object or the farther the object is moved, the more work that is done. To see the effects of force and distance on work, compare the weight lifters in the Figure 1.2. The two weight lifters on the left are lifting the same amount of weight, but the one on the bottom is lifting the weight a greater distance. Therefore, this weight lifter is doing more work. The two weight lifters on the bottom right are both lifting the weight the same distance, but the weight lifter on the left is lifting a heavier weight, so she is doing more work.
Example Output:
you do more work lifting an object if the object is