Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Ex Input:
Acute myeloid leukemia and lung cancer occurring in a chronic lymphocytic leukemia patient treated with fludarabine and autologous peripheral blood stem-cell transplantation.

Ex Output:
adverse drug event


Ex Input:
Fatal interstitial lung disease after erlotinib administration in a patient with radiation fibrosis.

Ex Output:
adverse drug event


Ex Input:
Occasionally, despite good therapeutic response, clozapine must be stopped due to dangerous side effects such as agranulocytosis.

Ex Output:

adverse drug event