TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Penobscot tribal chiefs expressed a willingness to enter peace talks with Lieutenant Governor Dummer in December 1724. They were opposed in this by French authorities, who continued to encourage the conflict, but Massachusetts Lieutenant Governor Dummer announced a cessation of hostilities on 31 July 1725 following negotiations in March.:83 The terms of this preliminary agreement were negotiated by Dummer and Chiefs Loron and Wenemouet and applied only to the Penobscots at first. They were allowed to retain Jesuit priests, but the two parties were in disagreement concerning land titles and British sovereignty over the Wabanakis. The written agreement was translated into Abenaki by French Jesuit Etienne Lauverjat; Chief Loron immediately repudiated it, specifically rejecting claims of British sovereignty over him. Despite his disagreement, Loron pursued peace, sending wampum belts to other tribal leaders, although his envoys were unsuccessful in reaching Gray Lock, who continued his raiding expeditions. Peace treaties were signed in Maine on 15 December 1725 and in Nova Scotia on 15 June 1726, involving a large number of tribal chiefs. The peace was reconfirmed by all except Gray Lock at a major gathering at Falmouth in the summer of 1727; other tribal envoys claimed that they were not able to locate him. Gray Lock's activity came to an end in 1727, after which time he disappears from English records.

SOLUTION: At what event was Gray Lock discovered to be missing?

PROBLEM: In chronic lymphocytic leukemia (CLL) signals from the B cell receptor (BCR) play a major role in disease development and progression. In this light, new therapies that specifically target signaling molecules downstream of the BCR continue to be developed. While first studies on the selective small molecule inhibitor of Bruton's tyrosine kinase (Btk), Ibrutinib (PCI-32765), demonstrated that Btk inhibition sensitizes CLL cells to apoptosis and alters their migratory behavior, these studies however did not address whether Btk-mediated signaling is involved in the process of CLL leukemogenesis. To investigate the requirement of Btk signaling for CLL development, we modulated Btk expression in the IgH.ET CLL mouse model, which is based on sporadic expression of the simian oncovirus SV40 T-antigen in mature B cells. To this end, we crossed IgH.ET mice on a Btk-deficient background or introduced a human Btk transgene (CD19-hBtk). Here we show that Btk deficiency fully abrogates CLL formation in IgH.ET mice, and that leukemias formed in Btk haplo-insufficient mice selectively expressed the wild-type Btk allele on their active X chromosome. Conversely, Btk overexpression accelerated CLL onset, increased mortality, and was associated with selection of non-stereotypical BCRs into CLL clones. Taken together, these data show that Btk expression represents an absolute prerequisite for CLL development and that Btk mediated signaling enhances leukemogenesis in mice. We therefore conclude that in CLL Btk expression levels set the threshold for malignant transformation.

SOLUTION: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?

PROBLEM: Copper of Kargaly origin was distributed during Bronze Age over a vast territory within the steppe and forest-steppe of Eastern Europe.

SOLUTION:
What is the product of Kargaly?