In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Input: Consider Input: Paragraph: The À1 ribosomal frameshifting requires the existence of an in cis RNA slippery sequence and is promoted by a downstream stimulator RNA. An atypical RNA pseudoknot with an extra stem formed by complementary sequences within loop 2 of an H-type pseudoknot is characterized in the severe acute respiratory syndrome coronavirus (SARS CoV) genome. This pseudoknot can serve as an efficient stimulator for À1 frameshifting in vitro. Mutational analysis of the extra stem suggests frameshift efficiency can be modulated via manipulation of the secondary structure within the loop 2 of an infectious bronchitis virus-type pseudoknot. More importantly, an upstream RNA sequence separated by a linker 5 0 to the slippery site is also identified to be capable of modulating the À1 frameshift efficiency. RNA sequence containing this attenuation element can downregulate À1 frameshifting promoted by an atypical pseudoknot of SARS CoV and two other pseudoknot stimulators. Furthermore, frameshift efficiency can be reduced to half in the presence of the attenuation signal in vivo. Therefore, this in cis RNA attenuator represents a novel negative determinant of general importance for the regulation of À1 frameshift efficiency, and is thus a potential antiviral target. 
 Title: An atypical RNA pseudoknot stimulator and an upstream attenuation signal for À1 ribosomal frameshifting of SARS coronavirus

Output: False


Input: Consider Input: Paragraph: Several French regions where COVID19 has been reported currently show a renewed increase in ILI cases in the general practice based Sentinelles network. Here we computed the number of excess cases by region and found correlation with the number of reported COVID19 cases so far. These data suggest larger circulation of SARS-CoV-2 in the French population than apparent from confirmed cases. 
 Title: Excess cases of Influenza like illnesses in France synchronous with COVID19 invasion. Pierre-Yves Boëlle 1 and the Sentinelles syndromic and viral surveillance group

Output: True


Input: Consider Input: Paragraph: Biomedical research in human beings is largely restricted to in vitro studies that lack complexity of a living organism. To overcome this limitation, humanized mouse models are developed based on immunodeficient characteristics of severe combined immunodeficiency (SCID) or recombination activating gene (Rag) null mice, which can accept xenografts. Peripheral constitution of human immunity in SCID or Rag null mice has been achieved by transplantation of mature human immune cells, foetal human thymus, bone marrow, liver tissues, lymph nodes or a combination of these, although efficiency needs to be improved. These mouse models with constituted human immunity (defined as humanized mice in the present text) have been widely used to investigate the basic principles of human immunobiology as well as complex pathomechanisms and potential therapies of human diseases. Here, elements of an ideal humanized mouse model are highlighted including genetic and non-genetic modification of recipient mice, transplantation strategies and proposals to improve engraftments. The applications of the humanized mice to study the development and response of human immune cells, human autoimmune diseases, virus infections, transplantation biology and tumour biology are reviewed as well. 
 Title: Mouse models with human immunity and their application in biomedical research Molecular Cell Biology • Introduction • Recipient mouse selection for engrafting xenogeneic human haematopoietic and immune cells • Pre-conditioning regimens for establishing humanized mice -Depletion of innate immune cells in recipient mice -Implication of human growth factors -Making 'space' for donor cells by irradiation or chemical agents • Transplantation strategies to establish humanized mice -Humanized mice achieved by directly implanting mature human immune cells -Humanized mice established by engrafting human HSCs -Humanized mice achieved by engrafting human thymus and HSCs • A proposed ideal humanized mouse model • Applications of humanized mouse models in biomedical research -Ontogeny of human HSCs and immunocell lineages -Autoimmune diseases -Virus infections -Immune response or tolerance to allografts or xenografts -Anti-tumour immune response • Conclusions and perspectives


Output: False