Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Q: The clinical and histologic presentation of this side effect and possible biochemical mechanisms of pathogenesis are discussed.

A: non-adverse drug event
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Q: However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.

A: adverse drug event
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Q: Acute renal failure following intravenous immunoglobulin therapy in a HIV-infected patient.

A:
adverse drug event
****