Given a passage, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.
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Question: To ascertain whether inoculation of lipopolysaccharide (LPS) into the mouse cochlea might induce enhancement of DNA binding activity of NK-kappa B and to establish a positive model of NF-kappa B activation in the cochlea.', 'Two groups of CBA mice were transtympanically injected either with 10 micrograms of LPS or an equal volume of saline. The nuclear proteins of the cochlea were extracted, quantitated and bound with 32P-radiolabeled oligonucleotide probe for NF-kappa B. The bound and free probes were separated by electrophoresis on a 4.5% native polyacrylamide gel. Supershift assays were carried out using the antibodies against NF-kappa B subunit P65 and P50.', 'The radiolabeled probe bound differently to nuclear extracts from the LPS-treated and the saline-treated mouse cochleae, showing that LPS inoculation significantly increased NF-kappa B binding activity. Supershift analysis demonstrated that the enhancement of DNA binding activity was related to both P65 and P50 subunits.

Answer: Does [ Lipopolysaccharide enhance DNA binding activity of nuclear factor-kappa B in the mouse cochlea ]?


Question: Endometrial cancers (ECs) are the most common form of gynecologic malignancy. Recent studies have reported that ECs reveal distinct markers for molecular pathogenesis, which in turn is linked to the various histological types of ECs. To understand further the molecular events contributing to ECs and endometrial tumorigenesis in general, a more precise identification of cancer-associated molecules and signaling networks would be useful for the detection and monitoring of malignancy, improving clinical cancer therapy, and personalization of treatments.', 'ECs-specific gene co-expression networks were constructed by differential expression analysis and weighted gene co-expression network analysis (WGCNA). Important pathways and putative cancer hub genes contribution to tumorigenesis of ECs were identified. An elastic-net regularized classification model was built using the cancer hub gene signatures to predict the phenotypic characteristics of ECs. The 19 cancer hub gene signatures had high predictive power to distinguish among three key principal features of ECs: grade, type, and stage. Intriguingly, these hub gene networks seem to contribute to ECs progression and malignancy via cell-cycle regulation, antigen processing and the citric acid (TCA) cycle.

Answer: Does visual gene-network analysis reveal the cancer gene co-expression in human endometrial cancer?


Question: Limited studies have examined ethnic variation in breastfeeding and complementary feeding practices in developing countries. This study investigated ethnic variation in feeding practices in mothers with children 0-23 months old in Vietnam.', 'We used data on 1875 women who came from the ethnic majority, Kinh (n\u2009=\u2009989, randomly sampled from 9875 surveyed Kinh mothers, 10\xa0% from each province) and three ethnic minorities: E De-Mnong (n\u2009=\u2009309), Thai-Muong (n\u2009=\u2009229) and Tay-Nung (n\u2009=\u2009348). Ethnic minorities were compared with the Kinh group using logistic regression model.', 'Prevalence of breastfeeding initiation within an hour of birth was 69\xa0% in Thai-Muong, but ~50\xa0% in other ethnicities. In logistic regression, the prevalence of breastfeeding within one hour was lower in Tay-Nung (OR: 0.54; 95\xa0% CI: 0.38, 0.77) than the majority Kinh. Prevalence of exclusive breastfeeding under 6\xa0months was 18, 10, 17, and 33\xa0% in Kinh, Thai-Muong, Tay-Nung, and E De-Mnong, respectively; compared to the majority Kinh, the prevalence was lower in Thai-Muong (OR: 0.42; 95\xa0% CI: 0.25, 0.71) and higher in E De-Mnong (OR: 1.99; 95\xa0% CI: 1.04, 3.82). Overall prevalence of bottle feeding in Thai-Muong and E De-Mnong (~20\xa0%) was lower than in Kinh (~33\xa0%): Thai-Muong (OR: 0.50; 95\xa0% CI: 0.37, 0.68) and E De-Mnong (OR: 0.69; 95\xa0% CI: 0.50, 0.95). Compared with Kinh (75\xa0%), fewer ethnic minority children received minimum acceptable diets (33\xa0% in Thai-Muong, 46\xa0% in E De-Mnong, and 52\xa0% in Tay-Nung; P\u2009<\u20090.05). Prevalence of minimum acceptable diet (met both dietary frequency and diversity) was lower in Thai-Muong (OR: 0.23; 95\xa0% CI: 0.11, 0.46), Tay-Nung (OR: 0.52; 95\xa0% CI: 0.39, 0.69), and E De-Mnong (OR: 0.55; 95\xa0% CI: 0.33, 0.89) than the majority Kinh.

Answer:
Do infant and young child feeding practices differ by ethnicity of Vietnamese mothers?