Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Q: Context: Stress is the force applied to an object. In geology, stress is the force per unit area that is placed on a rock. Four types of stresses act on materials. A deeply buried rock is pushed down by the weight of all the material above it. Since the rock cannot move, it cannot deform. This is called confining stress. Compression squeezes rocks together, causing rocks to fold or fracture (break) (Figure 1.1). Compression is the most common stress at convergent plate boundaries. Stress caused these rocks to fracture. Rocks that are pulled apart are under tension. Rocks under tension lengthen or break apart. Tension is the major type of stress at divergent plate boundaries. When forces are parallel but moving in opposite directions, the stress is called shear (Figure 1.2). Shear stress is the most common stress at transform plate boundaries. Shearing in rocks. The white quartz vein has been elongated by shear. When stress causes a material to change shape, it has undergone strain or deformation. Deformed rocks are common in geologically active areas. A rocks response to stress depends on the rock type, the surrounding temperature, the pressure conditions the rock is under, the length of time the rock is under stress, and the type of stress. Rocks have three possible responses to increasing stress (illustrated in Figure 1.3): elastic deformation: the rock returns to its original shape when the stress is removed. plastic deformation: the rock does not return to its original shape when the stress is removed. fracture: the rock breaks. Under what conditions do you think a rock is more likely to fracture? Is it more likely to break deep within Earths crust or at the surface? What if the stress applied is sharp rather than gradual? At the Earths surface, rocks usually break quite quickly, but deeper in the crust, where temperatures and pressures are higher, rocks are more likely to deform plastically. Sudden stress, such as a hit with a hammer, is more likely to make a rock break. Stress applied over time often leads to plastic deformation. Click image to the left or use the URL below. URL: 
 Question: rocks that are pulled apart are under

A: tension
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Q: Context: Common cellular and molecular mechanisms including protein aggregation and inclusion body formation are involved in many neurodegenerative diseases. -Synuclein is a major component of Lewy bodies in Parkinson's disease (PD) as well as in glial cytoplasmic inclusions in multiple system atrophy (MSA). Tau is a principal component of neurofibrillary and glial tangles in tauopathies. Recently, TDP-43 was identified as a component of ubiquitinated inclusions in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. PD is traditionally considered a movement disorder with hallmark lesions in the brainstem pigmented nuclei. However, pathological changes occur in widespread regions of the central and peripheral nervous systems in this disease. Furthermore, primary glial involvement ("gliodegeneration") can be observed in PD and MSA as well as in tauopathy. The present article reviews abnormal protein accumulation and inclusion body formation inside and outside the central nervous system. 
 Question: Which is the primary protein component of Lewy bodies?

A: αsyn
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Q: Context: Nerve growth factor (NGF) is an important mediator of pain and hyperalgesia and has become a target of novel analgesic therapeutics. Tanezumab is a humanized IgG(2) antibody that binds NGF with high affinity and specificity. In a study to assess the toxicity and pharmacokinetic properties of tanezumab in adult, male and female, cynomolgus monkeys following weekly intravenous administration of 1, 10, or 30 mg/kg for up to 26 weeks (followed by an 8-week recovery period), tanezumab was well tolerated with no macroscopic or microscopic effects on those brain, spinal cord, nerve, or ganglia sections evaluated. One fifth of tanezumab-treated monkeys developed an antibody response to tanezumab that prevented maintenance of tanezumab exposure between dosing. In the antibody-negative animals, accumulation of tanezumab was observed; steady state was achieved approximately 8 weeks after the first dose of study drug, and exposure to tanezumab was approximately dose proportional with no observed difference between male and female animals. One monkey died during the study; this monkey had findings suggestive of hypersensitivity reaction. The favorable toxicity and pharmacokinetic profile of tanezumab seen in this study supports its further evaluation for the treatment of pain in clinical practice. 
 Question: What is the target of tanezumab?

A:
ngf
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