Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
Chronic myeloid leukaemia (CML) is characterised by the occurrence of the Philadelphia (Ph) chromosome (9/22 translocation) and the formation of a fusion protein--the BCR-ABL transcript with constitutive activation of the BCR-ABL tyrosine kinase and consequent changes in the intracellular signal transduction, which is responsible for the deregulated myeloid cell proliferation. STI571 (signal transduction inhibition number 571) is a potent and selective inhibitor of the BCR-ABL tyrosine kinase. In the chronic phase of the disease, normal peripheral blood values are achieved within the first month of treatment in the large majority of patients and in many patients also a cytogenic response within the following months. The results in the advanced phase are far less favourable, which is explained by the development of resistance owing to reactivation of the BCR-ABL signal transduction. Side effects are primarily nausea, vomiting, various rashes, oedema, most often in the periorbital region, and musculoskeletal symptoms, including muscle cramps. Perspectives for treatment with STI571 are described, as are combinations with alpha-interferon and other cytostatics with a synergistic profile.

Ex Output:
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Ex Input:
"When I grow up, I want to be..." Almost all of us have thought about, or been asked to think about, our future careers. Our answers may differ greatly. Even now your aspirations may have changed from when you were in primary school. However, it seems career options aren't only based on personal taste. In a survey carried out by Teens, doctors, lawyers, and bankers were some of most popular careers that people said they hoped to follow. This is in line with a similar survey carried out in the UK in May 2011 by job website monster. Co.uk, in which medicine was the top choice among UK teenagers aged between 13 and 17. Medicine and law are two of the oldest and best known professions. Their prestige may come from the fact that doctors and lawyers are some of the most esteemed members of society, and they make good money. Joining these high-profile professions is often seen as a sign of upward social mobility. It is equally unsurprising that banking is now one of the most common career choices. Youngsters worldwide think of banking and see the money rolling in. Wealth is increasingly becoming one of the most important indicators of a successful career. British young men list the UK tycoon Alan Sugar, Microsoft founder Bill Gates and Facebook chief Mark Zuckerberg as their top role models "for their wealth". Just as Chinese teenagers see being a banker as a good and fun pathway to "wealth". However, not every child has the makings of doctor, lawyer, or banker. They are those who see fulfillment and happiness in other areas, and many teenagers dare to ink more individuality into their career options. As the Teens' survey discovered, a variety of unconventional jobs---coffee shop owner, gourmet ,waiter at a fast food restaurant---are among teenagers' career choices. They can be equally interesting and rewarding jobs. With every choice comes responsibility and challenge, and all career paths require specific education and training, you have to learn to balance optimism and confidence with being realistic about your particular talents and skills.

Ex Output:
What is the top career choice among UK teenagers aged between 13 and 17 according to the article?


Ex Input:
Did you know that blood is a tissue? Blood is a fluid connective tissue that is made up of red blood cells, white blood cells, platelets, and plasma. The cells that make up blood are pictured below ( Figure 1.1). The different parts of blood have different roles. A scanning electron microscope (SEM) image of human blood cells. Red blood cells are the flat, bowl-shaped cells, the tiny disc-shaped pieces are platelets, and white blood cells are the round cells shown in the center. If you were to filter out all the cells in blood, a golden-yellow liquid would be left behind. Plasma is this fluid part of the blood. Plasma is about 90% water and about 10% dissolved proteins, glucose, ions, hormones, and gases. Blood is made up mostly of plasma. Red blood cells (RBCs) are flattened, disk-shaped cells that carry oxygen. They are the most common blood cell in the blood. There are about 4 to 6 million RBCs per cubic millimeter of blood. Each RBC has about 200 million molecules of hemoglobin. Hemoglobin is the protein that carries oxygen. Hemoglobin also gives the red blood cells their red color. Red blood cells ( Figure 1.2) are made in the red marrow of long bones, rib bones, the skull, and vertebrae. Each red blood cell lives for only 120 days (about four months). After this time, they are destroyed in the liver and spleen. Mature red blood cells do not have a nucleus or other organelles. Lacking these components allows the cells to have more hemoglobin and carry more oxygen. The flattened shape of red blood cells helps them carry more oxygen than if they were rounded. White blood cells (WBCs) are usually larger than red blood cells. They do not have hemoglobin and do not carry oxygen. White blood cells make up less than one percent of the bloods volume. Most WBCs are made in the bone marrow, and some mature in the lymphatic system. There are different WBCs with different jobs. WBCs defend the body against infection by bacteria, viruses, and other pathogens. WBCs do have a nucleus and other organelles. Neutrophils are WBCs that can squeeze through capillary walls and swallow particles such as bacteria and parasites. Macrophages are large WBCs that can also swallow and destroy old and dying cells, bacteria, or viruses. Below, a macrophage is attacking and swallowing two particles, possibly disease-causing pathogens ( Figure Lymphocytes are WBCs that fight infections caused by viruses and bacteria. Some lymphocytes attack and kill cancer cells. Lymphocytes called B-cells make antibodies. A type of white blood cell, called a macrophage, is attacking a cancer cell. Platelets ( Figure 1.4) are very small, but they are very important in blood clotting. Platelets are not cells. They are sticky little pieces of larger cells. Platelets bud off large cells that stay in the bone marrow. When a blood vessel gets cut, platelets stick to the injured areas. They release chemicals called clotting factors, which cause proteins to form over the wound. This web of proteins catches red blood cells and forms a clot. This clot stops more blood from leaving the body through the cut blood vessel. The clot also stops bacteria from entering the body. Platelets survive in the blood for ten days before they are removed by the liver and spleen.

Ex Output:

which is the most common blood cell in the blood?