Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: Lack of the yeast Rrm3p DNA helicase causes replication defects at multiple sites within ribosomal DNA (rDNA), including at the replication fork barrier (RFB). These defects were unaltered in rrm3 sir2 cells. When the RFB binding Fob1p was deleted, rrm3-generated defects at the RFB were eliminated, but defects at other rDNA sites were not affected. Thus, specific protein-DNA complexes make replication Rrm3p-dependent. Because rrm3-induced increases in recombination and cell cycle length were only partially suppressed in rrm3 fob1 cells, which still required checkpoint and fork restart activities for viability, non-RFB rrm3-induced defects contribute to rDNA fragility and genome instability.
Example Output: What is the effect of the absence of Saccharomyces cerevisiae Rrm3p?

Example Input: Chronic myeloid leukemia (CML) is arguably the best understood of all human malignancies. Its origins in the hematopoietic stem cell can be traced to a reciprocal translocation involving chromosomes 9 and 22, dubbed the Philadelphia chromosome, which is observed in essentially all patients. The resulting fusion gene, BCR/ABL, encodes an activated tyrosine kinase that can act alone to induce a CML-like syndrome in mouse models. These animal models have validated BCR/ABL as a target for the development of specific pharmaceutical inhibitors. The kinase inhibitor imatinib mesylate (Gleevec) is highly specific, effective, and minimally toxic, but may not effect cures as a single agent, particularly in patients with accelerated and blast-phase disease. Resistance to imatinib can confound therapy. Surprisingly, a high percentage of resistant cases manifest intact or augmented BCR/ABL signaling, suggesting that this oncoprotein, or signaling pathways emanating from it, remain viable targets. Combination chemotherapy is under active investigation, and among the most compelling strategies is dual treatment with agents that both target BCR/ABL signal transduction. BCR/ABL activates Ras, and compounds designed to antagonize Ras function called farnesyl transferase inhibitors (FTIs) have shown potent activity in vitro and in animal models of BCR/ABL-induced leukemia. Initial clinical trials in patients with refractory acute myeloid leukemia and CML in blast crisis have shown significant activity, suggesting that trials combining imatinib and FTIs are warranted.
Example Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

Example Input: English is an important global language, but that doesn't mean it's easy to learn. Many experts have tried to make English easier for students to learn--but they weren't always successful. In 1930, Professor CK Ogden of Cambridge University invented Basic English. It had only 850 words (and just eighteen verbs) and Ogden said most people could learn it in just thirty hours. The problem was that people who learned Basic English could write and say simple messages, but they couldn't understand the answers in "real" English! It was also impossible to explain a word if it wasn't in the Basic English word list. For example, if you wanted a watermelon, you asked for "a large green fruit with the form of an egg, which has a sweet red inside and a good taste"! RE Zachrisson, a university professor in Sweden, decided that the biggest problem for learners of English was spelling, so he invented a language called Anglic. Anglic was similar to English, but with much simpler spelling. "Father" became "faadher", "new" became "nue' and "years" became "yeerz". Unfortunately for some students of English, Anglic never became popular. Even easier is the language which ships' captains use: it's called "Seaspeak". Seaspeak uses a few simple phrases for every possible situation. In Seaspeak, for example, you don't say, "I'm sorry what did you say?" or "I didn't understand, can you repeat that?" It's just "Say again." No more grammar! In the age of international communication through the Internet who knows? ... a new form of English might appear. A large number of the world's e-mails are in English and include examples of "NetLingo" like OIC (Oh, I see) and TTYL (Talk to you later). In another fifty years, English might not exist ... we will probably all speak fluent Internetish!
Example Output:
According to Professor Zachrisson, what was the biggest problem for learners of English?