Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Ex Input:
About three weeks into the therapy regimen, he complained of severe retrosternal chest oppression.

Ex Output:
non-adverse drug event


Ex Input:
Her course, history and outcome are presented and the pharmacokinetics, the mechanism of action, signs and symptoms and treatment of strychnine poisoning are reviewed.

Ex Output:
non-adverse drug event


Ex Input:
The management of unresectable metastatic melanoma is a major clinical challenge because of the lack of reliably effective systemic therapies.

Ex Output:

non-adverse drug event