Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
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Question: Context: The endocrine system is a system of glands that release chemical messenger molecules into the blood stream. The messenger molecules are called hormones. Hormones act slowly compared with the rapid transmission of electrical impulses of the nervous system. Endocrine hormones must travel through the bloodstream to the cells they control, and this takes time. On the other hand, because endocrine hormones are released into the bloodstream, they travel to cells everywhere in the body. For a good visual introduction to the endocrine system, watch this short video: http MEDIA Click image to the left or use the URL below. URL: An endocrine gland is a gland that secretes hormones into the bloodstream for transport around the body (instead of secreting hormones locally, like sweat glands in the skin). Major glands of the endocrine system are shown in Figure 20.17. The glands are the same in males and females except for the ovaries and testes. The hypothalamus is actually part of the brain, but it also secretes hormones. Some of its hormones go directly to the pituitary gland in the endocrine system. These hypothalamus hormones tell the pituitary to either secrete or stop secreting its hormones. In this way, the hypothalamus provides a link between the nervous and endocrine systems. The hypothalamus also produces hormones that directly regulate body processes. For example, it produces antid- iuretic hormone. This hormone travels to the kidneys and stimulates them to conserve water by producing more concentrated urine. The pea-sized pituitary gland is just below the hypothalamus and attached directly to it. The pituitary receives hormones from the hypothalamus. It also secretes its own hormones. Most pituitary hormones control other endocrine glands. Thats why the pituitary gland is called the master gland of the endocrine system. Table Pituitary Hormone Adrenocorticotropic (ACTH) hormone Target Glands/Cells adrenal glands Thyroid-stimulating (TSH) Growth hormone (GH) hormone thyroid gland Follicle-stimulating (FSH) hormone body cells ovaries or testes Luteinizing hormone (LH) ovaries or testes Prolactin (PRL) mammary glands Effects(s) Stimulates the cortex (outer layer) of the adrenal glands to secrete their hormones Stimulates the thyroid gland to se- crete its hormones Stimulates body cells to make pro- teins and grow Stimulates the ovaries to develop mature eggs; stimulates the testes to produce sperm Stimulates the ovaries or testes to secrete sex hormones; stimulates the ovaries to release eggs Stimulates the mammary glands to produce milk There are several other endocrine glands. Find them in Figure 20.17 as you read about them below. The thyroid gland is a relatively large gland in the neck. Hormones secreted by the thyroid gland include thyroxin. Thyroxin increases the rate of metabolism in cells throughout the body. The pancreas is a large gland located near the stomach. Hormones secreted by the pancreas include insulin. Insulin helps cells absorb glucose from the blood. It also stimulates the liver to take up and store excess glucose. The two adrenal glands are glands located just above the kidneys. Each adrenal gland has an outer layer (cortex) and inner layer (medulla) that secrete different hormones. The hormone adrenaline is secreted by the inner layer. It prepares the body to respond to emergencies. For example, it increases the amount of oxygen and glucose going to the muscles. The gonads are glands that secrete sex hormones. Male gonads are called testes. They secrete the male sex hormone testosterone. The female gonads are called ovaries. They secrete the female sex hormone estrogen. Sex hormones stimulate the changes of puberty. They also control the production of sperm or eggs by the gonads. Endocrine hormones travel throughout the body in the blood. However, each endocrine hormone affects only certain cells, called target cells. A target cell is the type of cell on which a given endocrine hormone has an effect. A target cell is affected by a given hormone because it has proteins on its surface to which the hormone can bind. When the hormone binds to target cell proteins, it causes changes inside the cell. For example, binding of the hormone might cause the release of enzymes inside the cell. The enzymes then influence cell processes. Endocrine hormones control many cell activities, so they are very important for homeostasis. 
 Question: Which gland secretes growth hormone?

Answer: pituitary gland


Question: Context: Chronic lymphocytic leukemia (CLL) cells depend on microenvironmental factors for proliferation and survival. In particular, the B-cell receptor (BCR) and nuclear factor- B (NF-B) pathways are activated in the lymph node (LN) microenvironment. Thus, model systems mimicking tumor-host interactions are important tools to study CLL biology and pathogenesis. We investigated whether the recently established NOD/scid/c(null) (NSG) mouse xenograft model can recapitulate the effects of the human microenvironment. We assessed, therefore, tumor characteristics previously defined in LN-resident CLL cells, including proliferation, and activation of the BCR and NF-B pathways. We found that the murine spleen (SP) microenvironment supported CLL cell proliferation and activation to a similar degree than the human LN, including induction of BCR and NF-B signaling in the xenografted cells. Next, we used this model to study ibrutinib, a Bruton's tyrosine kinase inhibitor in clinical development. Ibrutinib inhibited BCR and NF-B signaling induced by the microenvironment, decreased proliferation, induced apoptosis and reduced the tumor burden in vivo. Thus, our data demonstrate that the SP of xenografted NSG mice can, in part, recapitulate the role of the human LN for CLL cells. In addition, we show that ibrutinib effectively disrupts tumor-host interactions essential for CLL cell proliferation and survival in vivo. 
 Question: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?

Answer: ibrutinib


Question: Context: Josef von Halban (10 October 1870, Vienna -- 23 April 1937, Vienna) was an Austrian obstetrician and gynecologist. 
 Question: What city was Josef von Halban born in?

Answer:
vienna