Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: We describe the clinical characteristics and epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in children with cystic fibrosis (CF) from the U.S. CF center with the highest MRSA prevalence. Medical records of children with CF were retrospectively reviewed from 1997-2009. MRSA clinical isolates from 2007-2009 were analyzed by polymerase chain reaction and pulsed field gel electrophoresis. The prevalence of MRSA was 1% in 1997 and 49% in 2009. Fifty-five children (26%) had persistent MRSA infection. Sixty-eight percent of MRSA isolates were hospital-associated (HA) MRSA, of which 52% were pulsed-field type USA 100. Ninety-three percent of HA MRSA isolates were clindamycin resistant. Twelve children acquired MRSA before 1 year of age, 83% of whom were hospitalized prior to acquisition of MRSA. Ten of 11 sibling pairs carried indistinguishable MRSA strains. Children with persistent MRSA were hospitalized more often (P=.01), required inhaled medications more frequently (P=.01), and had higher rates of Pseudomonas aeruginosa coinfection (P<.001). MRSA prevalence in children with CF is increasing, and most children are infected with HA MRSA. Exposure to health care facilities and gastrointestinal surgeries may facilitate early acquisition of MRSA. Siblings carry indistinguishable MRSA strains, indicating household transmission of MRSA. Children with persistent MRSA had worse pulmonary morbidity. Coinfection with MRSA and P aeruginosa is likely associated with further increased pulmonary morbidity.
Example Output: What is MRSA?

Example Input: Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disease in adults. Classical ALS is characterized by the death of upper and lower motor neurons leading to progressive paralysis. Approximately 10% of ALS patients have familial form of the disease. Numerous different gene mutations have been found in familial cases of ALS, such as mutations in superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP-43), fused in sarcoma (FUS), C9ORF72, ubiquilin-2 (UBQLN2), optineurin (OPTN) and others. Multiple animal models were generated to mimic the disease and to test future treatments. However, no animal model fully replicates the spectrum of phenotypes in the human disease and it is difficult to assess how a therapeutic effect in disease models can predict efficacy in humans. Importantly, the genetic and phenotypic heterogeneity of ALS leads to a variety of responses to similar treatment regimens. From this has emerged the concept of personalized medicine (PM), which is a medical scheme that combines study of genetic, environmental and clinical diagnostic testing, including biomarkers, to individualized patient care. In this perspective, we used subgroups of specific ALS-linked gene mutations to go through existing animal models and to provide a comprehensive profile of the differences and similarities between animal models of disease and human disease. Finally, we reviewed application of biomarkers and gene therapies relevant in personalized medicine approach. For instance, this includes viral delivering of antisense oligonucleotide and small interfering RNA in SOD1, TDP-43 and C9orf72 mice models. Promising gene therapies raised possibilities for treating differently the major mutations in familial ALS cases.
Example Output: Which human disease is associated with mutated UBQLN2

Example Input: In the computer age, most of us take a broadband Internet connection for granted. Whether cable or mobile broadband, today's connections are many times faster than those in the early days. Videos play smoothly, complex websites load quickly, and files download much faster than ten years ago. And the files are much bigger too. There's _ , of course: You have to live near enough to a major city to get broadband Internet. If you don't, it's slow dial-up access for you. And for those living really far out, there may be no Internet access at all. Technology experts often talk about the "last mile" problem, which refers to the difficulty of bringing Internet access to remote locations. In cities and suburbs, it's relatively easy to provide access for everyone. It is much more difficult to deliver access to those living far from cities, especially in developing countries. Internet service providers, for their part, have been reluctant to provide access to sparsely populated areas. The handful of Internet users they would reach wouldn't cover the expense. But every year, technological advancements allow of more and more Internet users. Most broadband connections today run over existing cable TV and telephone lines although these technologies aren't available everywhere. Some companies have delivered the Internet over standard power lines. Advancements in cheaper, more efficient fiber optics cables promise to bring extremely fast Internet connections to more users. Still, the "last mile" problem remains hard to deal with. There will always be somewhere that doesn't have an affordable broadband connection. But someday that might not matter. If the rapid progress in cell phone technology is any indication , it may not be too long before an Internet connection simply follows you wherever you go.
Example Output:
What may eventually settle the "last mile" problem?