In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Input: Consider Input: Paragraph: So far, there has been scarce information about the status of immunoglobulins (Ig) and the gene expression of inflammatory cytokines in buffaloes showing digestive troubles. The purpose of the present study was to explore the modulation of gene expression of some immuneinflammatory markers in buffaloes suffered from various digestive disorders. For this reason, 50 native breed water buffaloes were studied. Forty of these buffaloes showed various symptoms of digestive disorders and were allocated into 4 groups of equal sizes (group 1: uncategorized stomatitis; group 2: acute traumatic reticuloperitonitis [TRR]; group 3: acute rumen impaction; and group 4: undifferentiated enteritis). Ten apparently healthy buffaloes were randomly selected and considered as a control group. RNA was firstly extracted from the whole blood then a reverse transcription kits was used to convert the RNA to cDNA. Real-time PCR was used to measure the expression of mRNAs of interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor (TNF)-α, IgG, and IgA, while glyceraldehyde-3-phosphate dehydrogenase (GAPDH) used as an internal reference. The results of realtime PCR revealed a significant (P ≤ 0.05) upregulation of the gene expression of IL-1β, IL-6, IL-10, and TNF-α in blood of diseased buffaloes compared with those of controls. Animals showing acute TRP had peak values of both IL-6 and IL-10; while those exhibiting enteritis and rumen impaction had the highest values of IL-1β and TNF-α, respectively. The results of qPCR also revealed a significant (P ≤ 0.05) downregulation of both IgG and IgA gene expression in blood of all diseased buffaloes compared with controls. The lowest values of both genes were recorded in buffaloes showing acute TRP. The results herein suggest that the tested genes could have a pivotal role in the pathophysiologic mechanism of the underlying diseases. 
 Title: Modulation of immunity and inflammatory gene expression in buffalo (Bubalus bubalis) with some digestive disorders

Output: True


Input: Consider Input: Paragraph: Recent results have provided increasing evidence for the existence of an intermediate membrane compartment between the rough endoplasmic reticulum and the Golgi complex which seems to function in protein sorting and the regulation of membrane traffic in the early part of the exocytic pathway . Localization of resident marker proteins has shown that this compartment consists of both peripheral and central elements . The aim of the present review is to combine the data on the pre-Golgi compartment with previous ideas of membrane traffic at the ER-Golgi interface . We propose a model which describes how mobile, endosome-like elements of the pre-Golgi compartment function in the generation of the compositional andfunctional boundary between the widely distributed ER and the more central4 located Golgi stacks . 
 Title: Pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the Golgi complex jaakko Saraste *t and Esa Kuismanent

Output: True


Input: Consider Input: Paragraph: A persistent infection by human coronavirus 229E (HCV/229E) was established in a human continuous cell line (L 132). Following the initial infection with stock HCV/229E, several cultures were established of which two (HV t and IIV4) have been maintained by continous passage for two years. These eultures have shed high titres of infectious virus continuously into the supernatant fluid since their initiation. The persistently infected ceils were resistant to homologous superinfection but supported polio virus replication to normal titres. Preliminary tests indicated that 50--100 percent of the cells contain virus. Neither interferon nor reverse transeriptase could be detected in these cultures and the presence of defective interfering particles could not be demonstrated. VH t and V H 4 coronaviruses, isolated from these persistently infected cultures (HV) and identified by 229E antiserum neutralization, were more eytoeidal than the parent virus as judged by plaque characteristics and CPE however, they were indistinguishable on the basis of density, EM morphology, a.nd genome size. Present evidence indicates that temperature plays an important but as yet undetermined role in the establishment and maintenance of stable 229 E persistently infected cell cultures. 0304-8608/81/0069/0117/$02.60 6, 128--132 (1975/76). 
 Title: Archives of Virology Establishment and Maintenance of a Persistent Infection of L 132 Cells by Human Coronavirus Strain 229E


Output: True