instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: Human adenoviral (HAd) vectors have demonstrated great potential as vaccine vectors. Preclinical and clinical studies have demonstrated the feasibility of vector design, robust antigen expression and protective immunity using this system. However, clinical use of adenoviral vectors for vaccine purposes is anticipated to be limited by vector immunity that is either preexisting or develops rapidly following the first inoculation with adenoviral vectors. Vector immunity inactivates the vector particles and rapidly removes the transduced cells, thereby limiting the duration of transgene expression. Due to strong vector immunity, subsequent use of the same vector is usually less efficient. In order to circumvent this limitation, nonhuman adenoviral vectors have been proposed as alternative vectors. In addition to eluding HAd immunity, these vectors possess most of the attractive features of HAd vectors. Several replication-competent or replication-defective nonhuman adenoviral vectors have been developed and investigated for their potential as vaccine delivery vectors. Here, we review recent advances in the design and characterization of various nonhuman adenoviral vectors, and discuss their potential applications for human and animal vaccination. 
 Title: Development of nonhuman adenoviruses as vaccine vectors
answer:
False


question:
Paragraph: The severe acute respiratory syndrome (SARS) pandemic revealed that zoonotic transmission of animal coronaviruses (CoV) to humans poses a significant threat to public health and warrants surveillance and the development of countermeasures. The activity of host cell proteases, which cleave and activate the SARS-CoV spike (S) protein, is essential for viral infectivity and constitutes a target for intervention. However, the identities of the proteases involved have been unclear. Pioneer studies identified cathepsins and type II transmembrane serine proteases as cellular activators of SARS-CoV and demonstrated that several emerging viruses might exploit these enzymes to promote their spread. Here, we will review the proteolytic systems hijacked by SARS-CoV for S protein activation, we will discuss their contribution to viral spread in the host and we will outline antiviral strategies targeting these enzymes. This paper forms part of a series of invited articles in Antiviral Research on ''From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.'' Ó 
 Title: Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research
answer:
False


question:
Paragraph: As the world faces its first influenza pandemic in 40 years, it has been argued that we have never been better prepared. Concern about emerging infectious diseases has fuelled significant public health and political developments, such as the coming into force of the International Health Regulations (IHR). Since the turn of the century, the World Health Organization (WHO) has documented a historically unprecedented number of emerging infectious disease outbreaks, and lessons drawn from their management have confirmed the critical importance of effective communications, specifically through formal channels such as WHO and in the public domain. In concert with novel emerging infectious diseases, the communication landscape itself has also changed radically. We now live in an era of real-time electronic communications; consequently, approaches to surveillance are being transformed. Data sources, information messengers, mechanisms of data and information transfer and audiences are all changing. Instant and global transmission of information has become a powerful ally, along with peer pressure, for WHO in ensuring that member states comply with new obligations to swiftly declare outbreaks considered to be of public health importance. There is now significant global attention and accompanying investment which should, the authors suggest, be used as an opportunity to improve strategic and operational communication capacity to respond not only to pandemic influenza but also to other public health threats. There are many concepts of communication in relation to risk associated with outbreaks. As these are relatively new concepts, this article will consider approaches relating to highlighting public health threats and supporting operational management, addressing these as the communication of risk and subsequent risk management. Strategic considerations are critical to both, although information, messengers, communication tools and audiences may differ. The communication of risk refers to the process by which information regarding outbreaks is identified and shared with the purpose of increasing awareness amongst key stakeholders of the threat. Key stakeholders for public health threats include WHO, national governments and the public. Risk management, by contrast, refers to the management processes associated with response to the outbreak, for which communication is crucial at each stage. Three examples are used to explore the challenges and demands of communicating effectively and coherently given this changing landscape. This brief paper will attempt to show the progress made, draw lessons to be learned and outline the ways forward. 
 Title: Risk communication and management in public health crises
answer:

True