Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: With an ageing population and improving cancer therapies, the two most common benign and malignant bone diseases, osteoporosis and bone metastases, will continue to affect an increasing number of patients. Our expanding knowledge of the molecular processes underlying these conditions has resulted in novel bone targets that are currently being explored in clinical trials. Clearly, the approval of denosumab, a monoclonal antibody directed against RANKL, has just marked the beginning of a new era for bone therapy with several additional new therapies lining up for clinical approval in the coming years. Potential agents targeting the osteoclast include cathepsin K, currently in phase 3 trials, and src inhibitors. Amongst anabolic agents, inhibitors of the Wnt-inhibitor sclerostin and dickkopf-1 are promising in clinical trials. Here, we will provide a comprehensive overview of the most promising agents currently explored for the treatment of bone diseases.

Answer: To the ligand of which receptors does Denosumab (Prolia) bind?


Question: It had been some time since Jack had seen the old man.Over the phone ,his mother told him,"Mr.Belser died last night ,The funeral is Wednesday."Memories flashed through his mind like an old newsreel as he sat quietly remembering his childhood days. When Jack was very young ,his father died.Mr Belser,who lived in the same neighborhood with them,spent as much time as he could to make sure Jack had a man's influence in his life.He spent a lot of time teachimg Jack he thought what was important in his following life.If Mr.Belser hadn' taught him how to weave,he wouldn't be in this business now.So he promised his mother he would attend Mr.Belser's funeral. "You'd better not drive your car.It's a long way."his mother warned him. Busy as he was,he kept his word.Though tired from the earliest flight,Jack tried his best to help.Mr.Belser's funeral was small because he had no children of his own and most of his s had passed away. The night before he had to return home,Jack and his mother stopped by to see the old house Mr.Belser once lived.Now it belonged to him.He bought the house from one of his s. The house was exactly as he remembered.Every step held memories.Every picture,every piece of furniture... Jadk stopped suddenly. The box on his desk was gone!He once asked the old man what was inside.He just smiled and said it was the most valuable thing to him,though it almost cost nothing to others.He figured that someone from the Belser family had taken it ."I will never know what was so valuable to him."Jack thought disappotntedly. Three days later returning home from work,Jack discovered a small package in his mailbox. The handwriting was difficult to read,but the return address caught his attention."Mr.Harold Belser"it read. Jack couldn't wait to open it .Inside lay the familiar small box.His heart racing,Jack unlocked the box.Inside he found a gold pocket watch with these words engraved:"Jack,Thanks for your time!Harold Belser." "The thing he valued most was my time."Jack held the watch before his chest,tears filling his eyes.

Answer: What did Mr.Belser teach Jack when he aws young?


Question: In a time when a dangerous number of people are overweight, many people seem to have forgotten the most important way to keep healthy and slim---exercise. And as a new study carried out on mice in the lab has shown, exercise done early in life can reward you in your adult years. A team of researchers at the University of California studied the effects of early exercise on adult physical activity, body mass and eating. They found that early-age exercise in mice has positive effects on adult levels of voluntary exercise in addition to reducing body mass. "These results may have an effect on the importance of regular physical education in elementary and middle schools," said Theodore Garland, a professor of biology, who led the research project. "If kids exercise regularly through their school years, then they may be more likely to exercise as adults, which could have far-reaching positive effects on human health and well-being." Although the positive effects of early-life exercise lasted for only one week, it is important to note that one week in the life of a mouse is the same as about nine months for humans. "Our results suggest that any positive effects of early-life exercise on adult exercise will need to be kept up if they are to be long-lasting." His team of researchers found, too, that all mice that had access to early exercise were lighter in weight than non-exercised mice. Garland explained that, in general, exercise will stimulate appetite sooner or later. However, it is possible that certain types of exercise, done for certain periods of time or at certain light levels, might not _ appetite much, if at all, at least in some individuals. "If we could understand what sorts of exercise these might be, then we might be able to tailor exercise recommendations in a way that would bring the benefits of exercise without increase in appetite, leading to a better chance of weight loss," he said.

Answer:
What is the article mainly about?