Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disease in adults. Classical ALS is characterized by the death of upper and lower motor neurons leading to progressive paralysis. Approximately 10% of ALS patients have familial form of the disease. Numerous different gene mutations have been found in familial cases of ALS, such as mutations in superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP-43), fused in sarcoma (FUS), C9ORF72, ubiquilin-2 (UBQLN2), optineurin (OPTN) and others. Multiple animal models were generated to mimic the disease and to test future treatments. However, no animal model fully replicates the spectrum of phenotypes in the human disease and it is difficult to assess how a therapeutic effect in disease models can predict efficacy in humans. Importantly, the genetic and phenotypic heterogeneity of ALS leads to a variety of responses to similar treatment regimens. From this has emerged the concept of personalized medicine (PM), which is a medical scheme that combines study of genetic, environmental and clinical diagnostic testing, including biomarkers, to individualized patient care. In this perspective, we used subgroups of specific ALS-linked gene mutations to go through existing animal models and to provide a comprehensive profile of the differences and similarities between animal models of disease and human disease. Finally, we reviewed application of biomarkers and gene therapies relevant in personalized medicine approach. For instance, this includes viral delivering of antisense oligonucleotide and small interfering RNA in SOD1, TDP-43 and C9orf72 mice models. Promising gene therapies raised possibilities for treating differently the major mutations in familial ALS cases.
Which human disease is associated with mutated UBQLN2

Australia has promised to introduce the most comprehensive carbon trading program outside Europe in 2010. The government in Canberra plans to cut greenhouse gas emissions by at least five percent by 2020, but it could make bigger reductions if other countries agree to tougher targets. The Australian government warns that without tough environmental measures the country could lose key industries and jobs. Climate Change Minister Penny Wong says the economy is under threat and decisive action is needed. Central to the government's climate change plan is a carbon emissions trading program that will be introduced within two years. It would involve one thousand of the nation's biggest companies and would cover about three-quarters of Australia's greenhouse gas emissions. Many scientists believe that greenhouse gases, such as carbon dioxide and methane, contribute to global warming. Many of them are released by burning fuels such as coal and oil. Companies will be required to buy permits for each ton of carbon they emit, although big polluting exporters will receive up to 90 percent of their carbon licenses free. Many business leaders want the government to delay the plan because of the current global financial crisis, which is slowing the Australian economy. Peter Anderson from the Australian Chamber of Commerce and Industry says it is irresponsible to bring in a carbon trading plan now. Environmentalists, on the other hand, say Prime Minister Kevin Rudd has not properly addressed the threat of climate change. Activists had sought a minimum emissions cut of 25 percent. Instead, the Rudd government aims to cuts carbon emissions by at least five percent of 2000 levels by 2020. That amount could rise to 15 percent, if future global agreements set such a target. Ray Nias of the environmental group WWF says Australia will pay the price for low targets. "This is a deeply, deeply disappointing target," Nias said. "It commits Australia to long-term climate change. It will make Australia's ability to negotiate global agreements very, very difficult. It is much lower than even we had imagined." Australia has one of the highest per-person greenhouse emissions rates in the world because of its reliance on coal for electricity. _
Who most probably agrees to a higher goal of carbon emissions?

Remember that H2 O is a polar molecule, so it can dissolve many substances (Figure 1.1). Salts, sugars, acids, bases, and organic molecules can all dissolve in water. Where does the salt in seawater come from? As water moves through rock and soil on land it picks up ions. This is the flip side of weathering. Salts comprise about 3.5% of the mass of ocean water, but the salt content, or salinity, is different in different locations. What would the salinity be like in an estuary? Where seawater mixes with fresh water, salinity is lower than average. What would the salinity be like where there is lots of evaporation? Where there is lots of evaporation but little circulation of water, salinity can be much higher. The Dead Sea has 30% salinity nearly nine times the average salinity of ocean water (Figure 1.2). Why do you think this water body is called the Dead Sea? In some areas, dense saltwater and less dense freshwater mix, and they form an immiscible layer, just like oil and water. One such place is a "cenote", or underground cave, very common in certain parts of Central America. Ocean water is composed of many sub- stances, many of them salts such as sodium, magnesium, and calcium chlo- ride. Because of the increased salinity, the wa- ter in the Dead Sea is very dense, it has such high salinity that people can easily float in it! With so many dissolved substances mixed in seawater, what is the density (mass per volume) of seawater relative to fresh water? Water density increases as: salinity increases temperature decreases pressure increases Differences in water density are responsible for deep ocean currents, as will be discussed in the "Deep Ocean Currents" concept. Click image to the left or use the URL below. URL:

water density increases when