TASK DEFINITION: In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
PROBLEM: Paragraph: One of the main tasks in biological sequence analysis is biological sequence comparison. Numerous efficient methods have been developed for sequence comparison. Traditional sequence comparison is based on sequence alignment. In this report, we propose a novel alignment-free method based on the relative Lempel-Ziv complexity to compare biological sequences. The vertebrate transferring genomes and the spike protein sequences are prepared and tested to evaluate the validity of the method. We use this method to build phylogenetic tree of two groups of the sequences. The result demonstrates that our method is powerful and efficient. 
 Title: A relative Lempel-Ziv complexity: Application to comparing biological sequences

SOLUTION: True

PROBLEM: Paragraph: Hepatitis C virus (HCV) infects more than 2 % of the world population with highest prevalence in parts of Africa and Asia. Past standard of care using interferon α and ribavirin had adverse effects and showed modest efficacy for some HCV genotypes spurring the development of direct acting antivirals (DAAs). Such DAAs target viral proteins and are thus better tolerated but they suffer from emergence of vial resistance. Furthermore, DAAs are often HCV genotype specific. Novel drug candidates targeting host factors required for HCV propagation, so called host-targeting antivirals (HTAs), promise to overcome both caveats. The genetic barrier to resistance is usually considered to be high for HTAs and all HCV genotypes presumably use the same host factors. Recent data, however, challenge these assumptions, at least for some HTAs. Here, we highlight the most important hosttargeting strategies against hepatitis C and critically discuss their opportunities and risks. 
 Title: Opportunities and Risks of Host-targeting Antiviral Strategies for Hepatitis C

SOLUTION: True

PROBLEM: Paragraph: Clinical patient profiles with H5N1 or SARS infection. The two cases of H5N1 infection have been reported previously (Uiprasertkul et al., 2005) . Briefly, the first case was a previously healthy 6year old boy who developed fever and shortness of breath. Despite antibiotic treatment he deteriorated and Chest X-Ray showed right lower lobe opacification. Nasopharyngeal aspirate was positive for influenza A and PCR showed positive result for H5 and negative for H1 and H3. He was started on oseltamivir 2 days before death. The second case was a 33 year old man with previous good health who was admitted with a 4-day history of fever, malaise, sore throat and cough with blood-stained sputum. Chest X-Ray showed right lower-lobe consolidation. Despite treatment with oseltamivir 2 days after admission his condition deteriorated and he developed ARDS. PCR for H5 was positive on day 6 of illness -the day on which he died. The clinical profiles of the nine SARS patients used in our study have been previously reported (Nicholls et al., 2006) . Human lung obtained from a patient who died of extra-pulmonary disease served as a normal control and was kindly provided by Prof. D. Kerjaschki, Department of Pathology, Medical University of Vienna, according to ethical guidelines. For mouse H5N1 infection experiment, female C57BL/6N mice (6-8 week of age) were used. Mice were anesthetized with isoflurane and infected intranasally with live H5N1 avian influenza virus (strain A/HK/483/97) at an equivalent TCID 50 dose of 10 2 and 10 1 . Mice were observed daily and euthanized for tissue sampling on day 4 after challenge. Lung tissues were collected and fixed in 10% formalin. The experiment was conducted in a biosafety level III laboratory. Lethal lung infections with Anthrax, Y. pestis, and monkey pox virus, as well as infections with Smallpox virus, Marburg virus, Western Equine Encephalitis virus (WEE), and Eastern Equine Encephalitis virus (EEE) and lung sampling were performed at the US Army Medical Research Institute of Infectious Diseases, Fort Detrick, according to institutional guidelines. The samples were obtained from USAMRIID's pathology archival collection. 
 Title: Supplemental Data Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury SUPPLEMENTAL EXPERIMENTAL PROCEDURES

SOLUTION:
False