instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: Survivors of acute respiratory failure commonly experience long-term psychological sequelae and impaired quality of life. For researchers interested in general mental health, using multiple condition-specific instruments may be unnecessary and inefficient when using the Medical Outcomes Study Short Form (SF)-36, a recommended outcome measure, may suffice. However, relationships between the SF-36 scores and commonly used measures of psychological symptoms in acute survivors of respiratory failure are unknown. Our objective is to examine the relationship of the SF-36 mental health domain (MH) and mental health component summary (MCS) scores with symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD) evaluated using validated psychological instruments. We conducted a cross-sectional analysis of 1,229 participants at 6- and 12-month follow-up assessment using data from five studies from the United States, the United Kingdom, and Australia. Symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS), Depression Anxiety Stress Scales, the Davidson Trauma Scale, Impact of Event Scale (IES), and IES-Revised (IES-R). At 6-month assessment there were moderate to strong correlations of the SF-36 MH scores with HADS depression and anxiety symptoms (r=-0.74 and -0.79) and with IES-R PTSD symptoms (r=-0.60) in the pooled analyses. Using the normalized population mean of 50 on the SF-36 MH domain score as a cut-off, positive predictive values were 16 and 55% for substantial depression; 20 and 68% for substantial anxiety (Depression Anxiety Stress Scales and HADS, respectively); and 40, 44, and 67% for substantial PTSD symptoms (IES-R, IES, and Davidson Trauma Scale, respectively). Negative predictive values were high. The area under the receiver operating characteristics curve of the SF-36 MH score was high for depression, anxiety, and PTSD symptoms (0.88, 0.91, and 0.84, respectively). All results were consistent for the MCS, across the individual studies, and for the 12-month assessment. For researchers interested in general mental health status, the SF-36 MH or MCS offers a strong measure of psychological symptoms prevalent among survivors of acute respiratory failure. For researchers interested in specific conditions, validated psychological instruments should be considered. 
 Question: Symptoms of which disorder are evaluated with the Davidson Trauma Scale?
answer:
ptsd


question:
Context: Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia chromosome, which is associated with a balanced translocation involving chromosomes 9 and 22 to produce a fusion gene (bcr-abl) that gives rise to a constitutively activated Abl tyrosine kinase. This kinase led to the discovery of several small-molecule inhibitors, imatinib being the first and most successful of these. Resistance to imatinib results in some patients from Abl kinase point mutations. Overcoming imatinib resistance represents one of the biggest challenges facing clinicians in the modern management of CML. In this review, we discuss the current understanding of CML pathophysiology and mechanisms of imatinib resistance and how advancing this knowledge has led to the design of novel therapies in the area of blastic phase CML and Philadelphia chromosome-positive acute lymphoblastic leukemia with previous imatinib failure. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
answer:
bcr-abl


question:
Context: When you take a walk along a beach, what do you find there? Sand, the ocean, lots of sunlight. You may also find shells. The shells you find are most likely left by organisms in the phylum Mollusca. On the beach, you can find the shells of many different mollusks ( Figure 1.1), including clams, mussels, scallops, oysters, and snails. Mollusks are invertebrates that usually have a hard shell, a mantle, and a radula. Their glossy pearls, mother of pearl, and abalone shells are like pieces of jewelry. Some mollusks, such as squid and octopus, do not have shells. The Mollusks body is often divided into different parts ( Figure 1.2): On the beach, you can find a wide variety of mollusk shells. 1. A head with eyes or tentacles. 2. In most species, a muscular foot, which helps the mollusk move. Some mollusks use the foot for burrowing into the sand, and others use it for jet-propulsion. 3. A mantle, or fold of the outer skin lining the shell. The mantle often releases calcium carbonate, which creates an external shell, just like the ones you find on the beach. The shell is made of chitin, a tough, semitransparent substance. 4. A mass housing the organs. 5. A complete digestive tract that begins at the mouth and runs to the anus. 6. Most ocean mollusks have a gill or gills to absorb oxygen from the water. 7. Many species have a feeding structure, the radula, found only in mollusks. The radula can be thought of as a "tongue-like" structure. The radula is made mostly of chitin. Types of radulae range from structures used to scrape algae off of rocks to the beaks of squid and octopuses. This is the basic body plan of a mollusk. Note the mantle, gills, and radula. Keep in mind the basic body plan can differ slightly among the mollusks. Mollusks are probably most closely related to organisms in the phylum Annelida, also known as segmented worms. This phylum includes the earthworm and leech. Scientists believe these two groups are related because, when they are in the early stage of development, they look very similar. Mollusks also share features of their organ systems with segmented worms. Unlike segmented worms, however, mollusks do not have body segmentation. The basic mollusk body shape is usually quite different as well. 
 Question: what type of worms are most closely related to mollusks?
answer:

segmented worms