You are given a background paragraph that describes one or more causal or qualitative relationships such as a relationship in economics or a scientific law and a story that makes use of the concepts or the relationship described in the provided paragraph. You need to come up with a question about the story that requires an understanding of the relationship described in the background paragraph. The generated question should not be answerable without both the background and story. Write a question about the story that requires a relationship in the background paragraph to answer. Check whether your question requires both the background paragraph and the story to answer. If your question can be answered by only one of these, try to rewrite your question so that it requires both. Note that "flipping" a word in the question can give rise to a new question where the answer will be different from the original question. Often, "flipping" a word gives rise to flipping the direction of the relationship, for example, from "increase" to "decrease."
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Question: Background Paragraph: When you go to the dentist to get a tooth pulled, you really don’t want to feel any pain. The dentist injects an anesthetic into your gum and it eventually becomes numb. One theory as to why anesthetics work deals with the movement of ions across the cell membrane. The anesthetic gets into the membrane structure and causes shifts in how ions move across the membrane. If ion movement is disrupted, nerve impulses will not be transmitted and you will not sense pain – at least not until the anesthetic wears off. 
Story: Two men, Sam and Frodo, go into the doctor's office to have the exact same procedure done to one of their arms. They won't need to be knocked out for this, but they will be given anesthetic to help with the pain. After the nurse administers the anesthetic to both men, the ions in Sam's arm continue moving across the membrane, but the ions in Frodo's arm stop moving. The doctor then comes in to begin the procedure.

Answer: Which man's nerve impulses are being transmitted?


Question: Background Paragraph: The example of someone having a positive experience with a drug is easy to see how drug dependence and the law of effect works. The tolerance for a drug goes up as one continues to use it after having a positive experience with a certain amount the first time.[38] It will take more and more to get that same feeling. This is when the controlled substance in an experiment would have to be modified and the experiment would really begin. The law of work for psychologist B. F. Skinner almost half a century later on the principles of operant conditioning, "a learning process by which the effect, or consequence, of a response influences the future rate of production of that response.[39]. 
Story: The Super Scoops met to discuss their experiences. They all said they always had a great experience using scoop and used the same amount each time. They told how many times they used scoop. Rosario used it 92 times, Sal used it 82 times, Bud used it 52 times, Hilario used it 42 times, Keven used it 32 times, Augustus used it 22 times, and Kory used it 12 times.

Answer: Who has a higher tolerance for scoop: Augustus or Rosario?


Question: Background Paragraph: Currently, millions of individuals with high cholesterol take a similar type of drug, known as a statin. The drug, an inhibitor of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis, decreases blood levels of cholesterol by induce the expression of low density lipoprotein (LDL) receptors in the liver. The increased levels of the LDL-receptors stimulate the catabolism of plasma LDL, removing cholesterol from plasma, which is an important determinant of atherosclerosis. You may know of people who take a statin to help with their cholesterol levels. However, these drugs probably work slightly differently in many of those people. In some, it lowers their cholesterol significantly; in others it may lower it only moderately; and in some, it may have no significant effect at all. (Luckily for those individuals, there are multiple versions of the statins, so different drugs can be tested to find the proper combination for that individual.) Why the difference? Because of the genetic background of all people; the different single nucleotide polymorphisms that make us all different. Pharmacogenomics, a combination of pharmacology and genomics (the study of the genome) that refers to the study of the relationship between pharmaceuticals and genetics, may explain and simplify this problem. 
Story: Uncle Tom and uncle Sam both have high cholesterol. Uncle Tom is on statin drugs and uncle Sam is not.

Answer:
Which uncle doesn't take a drug that works slightly differently in many people?