Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

[EX Q]: Paragraph: In recent decades, laughter has been touted as a possible cure for many ills, including cancer and heart trouble. But could mirth also be deadly, making the phrase “I just about died laughing” as much about accuracy as it is hyperbole? On 24 March 1975, 50-year-old bricklayer Alex Mitchell of King’s Lynn in Norfolk, England, kicked the bucket while roaring with laughter at one of his favorite television shows, the comedy program The Goodies. The skit that precipitated Mitchell’s fatal fit of glee involved a kilted Scotsman’s flailing away with his bagpipe at a vicious black pudding intent upon attacking him. Mitchell was unable to stop laughing, and after twenty-five minutes of uproar gave one last “tremendous belly laugh, slumped on the settee, and died,” said his widow, who witnessed his passing. While Mitchell had expired from heart failure, what felled him was not a classic heart attack, but rather the result of an unusual inheritable heart rhythm disorder that routinely takes the lives of even apparently robust 20-somethings. Mitchell had Long QT syndrome, an affliction in which the heart is prone to experiencing long pauses between heart beats, especially after instances of excitement or exertion. After such an incident, the heart resets itself after a few beats, but in some cases (such as this) the person is not so fortunate. An odder account of a “dying laughing” incident was reported in Bangkok in 2003:  An ice cream truck driver in Thailand died while laughing in his sleep. Damnoen Saen-um, 52, laughed for about two minutes yesterday and then stopped breathing, The Nation newspaper reported. Damnoen’s wife tried to wake him up but he kept laughing. An autopsy suggested that he might have had a heart attack. “I have never seen a case like this. But it is possible that a person could have heart seizure while laughing or crying too hard in their sleep,” said Dr Somchai Chakrabhand, deputy director-general of the Mental Health Department. On the anecdotal side, Schott’s Original Miscellany attributes the death of Burmese king Nandabayin in 1599 to his having “laughed to death when informed, by a visiting Italian merchant, that Venice was a free state without a king.”  And on the fictional front, one version of the demise of Pecos Bill, the legendary cowboy hero of American folklore, has him dying from laughter after an encounter with a Boston dude:  When Bill was gettin’ on in years, a Boston man came down to New Mexico for a visit. He fancied himself a bit of a cowboy. Got himself one of them mail-order suits, don’t ya know. The ones with the lizard skin boots, a shiny brass belt buckle, a new pair of blue jeans and a huge ten gallon hat with not a speck of dust on it. Well, when Pecos Bill saw him trying to swagger into a bar, he jest lay down on the sidewalk and laughed himself to death! Not enough information was given in the (real) cases cited above to know whether laughter was a coincidental, contributory, or causal element of the deaths, but linguistically we’ve been tossing about “dying laughing” expressions for centuries; the Oxford English Dictionary records a use of this phrase as far back as 1596 (“Went they not quickly, I should die with laughing”). We also employ similar phrases to indicate intense feelings of humiliation (“I almost died of embarrassment”), and in a more generic sense we use ‘dying’ to indicate great longing (“I’m just dying to see you”) or excellence (“It’s to die for”). It therefore comes as a bit of a shocker to realize that there might be at least a smidgen of truth buried deep beneath all this overblown emoting. Claim: People have died laughing.
[EX A]: Yet even if there may have been an occasional death from guffawing, it’s still possible merriment is far more healthy than harmful (at least for the ones who survive). Some studies assert laughing produces beneficial effects on physical health, including decreasing the secretion of serum cortisol (a stress hormone) and boosting the blood levels of immunoglobulin A, an antibody that fights bacterial and viral infections in the upper respiratory and gastrointestinal tracts. However, not everyone in the scientific community has jumped on this bandwagon: in a study reported upon in 2002 in Current Directions in Psychological Science (“Is Laughter the Best Medicine? Humor, Laughter, and Physical Health)  researchers reported that the connection between humor and wellness was “less conclusive than commonly believed” and that “future research in this area needs to be more theoretically driven and methodologically rigorous.”

[EX Q]: Paragraph: The Food and Drug Administration approved Medtronic’s CoreValve system based on U.S. clinical trials in which it was shown to be safe and effective while demonstrating low rates of stroke and valve leakage, the company said. CoreValve, in which the replacement valve is threaded into place through an artery using a catheter, spares patients chest-cracking surgery. The system has been available since 2007 in Europe, where it is not uncommon for medical devices to win approval several years ahead of the United States. Claim: U.S. FDA approves Medtronic heart valve replacement system.
[EX A]: Medtronic Inc’s non-invasive systems for replacing diseased heart valves won U.S. approval for use in patients deemed too frail to endure traditional open heart surgery, the U.S. medical device maker said on Friday.

[EX Q]: Paragraph: Scientists said on Wednesday many Tibetans possess a rare variant of a gene involved in carrying oxygen in the blood that they likely inherited from an enigmatic group of extinct humans who interbred with our species tens of thousands of years ago. It enables Tibetans to function well in low oxygen levels at elevations upwards of 15,000 feet (4,500 meters) like the vast high plateau of southwestern China. People without this variant would be apt to develop thick blood, leading to high blood pressure, heart attacks, strokes, low-birth-weight babies and higher infant mortality. This version of the EPAS1 gene is nearly identical to one found in Denisovans, a lineage related to Neanderthals - but is very different from other people today. Denisovans are known from a single finger bone and two teeth found in a Siberian cave. DNA testing on the 41,000-year-old bone indicated Denisovans were distinct from our species and Neanderthals. “Our finding may suggest that the exchange of genes through mating with extinct species may be more important in human evolution than previously thought,” said Rasmus Nielsen, a computational biology professor at the University of California, Berkeley and the University of Copenhagen, whose study appears in the journal Nature. Our genome contains residual genetic fragments from other organisms like viruses as well as species like Neanderthals with which early modern humans interbred. The researchers called their study the first to show that a gene from an archaic human species has helped modern humans adjust to different living conditions. “Such exchange of genes with other species may in fact have helped humans adapt to new environments encountered as they spread out of Africa and into the rest of the world,” said  Nielsen. Asan Ciren, a researcher with China’s BGI genomics center, added, “The genetic relationship or blood relationship between modern humans and archaic hominins is a hot topic of the current paleoanthropology.”  The researchers said early modern humans trekking out of Africa interbred with Denisovans in Eurasia en route to China. Their descendants harbor a tiny percentage of Denisovan DNA. Genetic studies show nearly 90 percent of Tibetans have the high-altitude gene variant, along with a small percentage of Han Chinese, who share a common ancestor with Tibetans. It is seen in no other people. The researchers conducted genetic studies on 40 Tibetans and 40 Han Chinese and performed a statistical analysis showing that the gene variant almost certainly was inherited from the Denisovans. The gene regulates production of hemoglobin, a protein in red blood cells that carries oxygen. It is turned on when blood oxygen levels drop, stimulating more hemoglobin production. At elevations above 13,000 feet (4,000 meters), the common form of the gene boosts hemoglobin and red blood cell production, causing dangerous side effects. The Tibetans’ variant increases hemoglobin and red blood cell levels only modestly, sparing them these effects. Claim: Gene from extinct human species fortifies high-altitude Tibetans.
[EX A]:
How do Tibetans thrive in high-altitude, low-oxygen conditions that would make others wither? Well, they may have received some help from an unexpected source.