Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
Aava Whistler Hotel Star Ratings: Location: Whistler Rooms:192 Stay at the Aava Whistler Hotel (formerly Coast Whistler Hotel) and experience a great vacation. The Aava Whistler Hotel is within minutes from over a hundred shopping malls and restaurants. It also has a great number of recreational facilities, including swimming, diving and even skiing. Hotel services include 24-hour reception, laundry and room service. Guests can stay in cozy rooms equipped with air-conditioning, bathroom and television. From CNY=496 per night. Best Western Cairn Croft Hotel Star Ratings: Location: East Lundy's Lane Room:l66 Relax and unwind at the Best Western Cairn Hotel. This resort-style hotel is located just minutes from the airport. At the Best Western Cairn Croft, guests can enjoy a large number of recreational facilities, including children's activities, sightseeing and a swimming pool. Business travelers can also take advantage of spacious meeting and banqueting facilities for hosting corporate events. All rooms come with basic amenities . From CNY=439 per night. Clarion Hotel&Suites Downtown Montreal Star Ratings: Location:Montreal Rooms:266 Conveniently located just 20 minutes from the airport, the Clarion Hotel&Suite Downtown Montreal is a moderately-priced three-star hotel that provides services to both business and leisure travelers. The Clarion has spacious meeting facilities and modern business centers for business travelers. It also has a sauna and whirlpool where guest can relax. All rooms come with basic amenities, including cable TV and a kitchenette. From CNY=553 per night. Delta Bow Valley Hotel Star Ratings: Location:Calgary Rooms:398 The Delta Bow Valley Hotel is located a couple of blocks north of Olympic Plaza, east of James Short Park, and north-east of the Petro-Canada Centre. Apart from business and recreational services such as a business centre, fitness centre and restaurant, all rooms in the Delta come with a mini-bar and in-house movies. From CNY=l, 227 per night.

Ex Output:
Which hotel offers facilities for children's activities?


Ex Input:
Ataxin-3 (AT3) is the protein that triggers the inherited neurodegenerative disorder spinocerebellar ataxia type 3 when its polyglutamine (polyQ) stretch close to the C-terminus exceeds a critical length. AT3 consists of the N-terminal globular Josephin domain (JD) and the C-terminal disordered one. It cleaves isopeptide bonds between ubiquitin monomers, an event involved in protein quality control mechanisms. AT3 has been implicated in the pathway that sorts aggregated protein to aggresomes via microtubules, in which dynein and histone deacetylase 6 (HDAC6) also seem to be involved. By taking advantage of small angle X-ray scattering (SAXS) and surface plasmon resonance (SPR), we have investigated the interaction of AT3 with tubulin and HDAC6. Based on SAXS results, the AT3 oligomer, consisting of 6-7 subunits, tightly binds to the tubulin hexameric oligomer in a "parallel" fashion. By SPR analysis we have demonstrated that AT3 binds to tubulin dimer with a 50nM affinity. Binding fits with a Langmuir 1:1 model and involves a single binding interface. Nevertheless, the interaction surface consists of three distinct, discontinuous tubulin-binding regions (TBR), one located in the JD, and the two others in the disordered domain, upstream and downstream of the polyQ stretch. In the absence of any of the three TBRs, the affinity is drastically reduced. By SPR we have also provided the first evidence of direct binding of AT3 to HDAC6, with affinity in the range 0.1-1M. These results shed light on the interactions among the components of the transport machinery that sorts aggregate protein to the aggresome, and pave the way to in vivo studies aimed at further clarifying their roles.

Ex Output:
Which is the protein implicated in Spinocerebellar ataxia type 3?


Ex Input:
The Philadelphia chromosome translocation (t(9;22)) results in the molecular juxtaposition of two genes, BCR and ABL, to form an aberrant BCR-ABL gene on chromosome 22. BCR-ABL is critical to the pathogenesis of chronic myelogenous leukemia and a subset of acute leukemias. The chimeric Bcr-Abl protein has constitutively elevated tyrosine phosphokinase activity. This abnormal enzymatic activation is critical to the oncogenic potential of Bcr-Abl. Initially, protein kinases were thought to be poor therapeutic targets because of their ubiquitous nature and crucial role in many normal physiologic processes. However, the advent of imatinib mesylate (Gleevec, Novartis Pharmaceuticals, Basel, Switzerland), formerly known as STI571 and CGP57148B, demonstrated that designer kinase inhibitors could be specific. This agent has shown striking activity in chronic myelogenous leukemia. It also inhibits phosphorylation of Kit (stem-cell factor receptor) and platelet-derived growth factor receptor. In addition, it has shown similar impressive responses, with little host toxicity, in gastrointestinal stromal tumors, which harbor activating Kit mutations, and in tumors with activated platelet-derived growth factor receptor. The studies of imatinib mesylate provide proof-of-principle for using aberrant kinases as a therapeutic target and are a model for the promise of molecular therapeutics. This paper reviews the current knowledge on the function of Bcr-Abl and its normal counterparts (Bcr and Abl), as well as the impact of this knowledge on the development of a remarkably successful targeted therapy approach.

Ex Output:

What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?