Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: The blockage of transcription elongation by RNA polymerase II (pol II) at a DNA damage site on the transcribed strand triggers a transcription-coupled DNA repair (TCR), which rapidly removes DNA damage on the transcribed strand of the expressed gene and allows the resumption of transcription. To analyze the effect of UV-induced DNA damage on transcription elongation, an in vitro transcription elongation system using pol II and oligo(dC)-tailed templates containing a cyclobutane pyrimidine dimer (CPD) or 6-4 photoproduct (6-4PP) at a specific site was employed. The results showed that pol II incorporated nucleotides opposite the CPD and 6-4PP and then stalled. Pol II formed a stable ternary complex consisting of pol II, the DNA damage template, and the nascent transcript. Furthermore, atomic force microscopy imaging revealed that pol II stalled at the damaged region. These findings may provide the basis for analysis of the initiation step of TCR.
[A]: Which gene strand is targeted by transcription-coupled repair (TCR)?


[Q]: Researchers from France and Italy discovered that Canadian parents are less strict with their children than mothers and fathers in France and Italy. "Our most important finding was the difference between Canadians and the others," said Professor Michel Claes,the lead author of the study."Canadians focus on independence and negotiation.On the other hand,Italians,for example,exercise more control.We found Canadians seem to focus on negotiation in case of a conflict." Claes said Canada,France and Italy were selected for the study because they share important cultural and social factors."We chose FrenchCanadians because they share the same language as France,and originally came from France and share certain values.Italy was included because it was considered to have similar,strong and important family values," he explained. The researchers examined the emotional ties between parents and their children by questioning 1,256 students aged 11 to 19 years old. Canadian students reported less control and more free actions,according to the study.Italian parents were stricter and French parents were somewhere in the middle. Claes explains that the differences lie in education in Canada,France and Italy. "North America has its own educational values,which promote individualization.Tolerance and comprehension are encouraged.Italy,on the other hand,promotes respect of authority,control,and the need for permission." he said. Children from all three countries described their mothers as warm and communicative.Italian and Canadian children had similar feelings about their fathers,and reported high levels of emotional ties.But French fathers were generally thought by their children to be more distant and cold. "We were surprised by this," Claes admitted."It seems as though the relationships between French mothers and their children were becoming closer over time,while fathers maintain a form of distance and coldness,which is more of a source of conflict in France than in the other countries."
[A]: According to Michel Claes,what mainly leads to the differences in parentchildren relationships among Canada,France and Italy?


[Q]: Neurofibromatosis type 1 (NF1) is a common disorder of dysregulated tissue growth secondary to mutations in the tumor suppressor gene NF1. Pulmonary arterial hypertension (PAH) in patients with NF1 is hypothesized to be secondary to an underlying vasculopathy. We describe the entity we term NF1-associated PAH (NF1-PAH) in four new patients and update the data on four previously published reports of patients with PAH and NF1. We performed genetic testing of the bone morphogenic protein receptor 2 (BMPR2) gene, which mutated in 70% of patients with familial PAH and approximately 25% of patients with idiopathic PAH. We report, for the first time, pathologic findings in the autopsy-obtained lung of one patient with NF1-PAH. Patients with NF1-PAH have a generally poor long-term prognosis. In four patients, we observed the mosaic pattern of lung attenuation on a CT scan of the chest, a radiographic finding that can be consistent with an underlying vasculopathy. No mutations or rearrangements in the BMPR2 gene were found. We observed complex plexiform lesions in the one available autopsy specimen. Similar lesions are a hallmark of plexogenic pulmonary arteriopathy and are associated with several severe types of PAH. (Plexiform lesions should not be confused with plexiform neurofibromas, which are distinctive tumors seen in NF1.) Our findings suggest that NF1 should be considered as being "associated with PAH as outlined in the Revised Clinical Classification of Pulmonary Hypertension. Understanding the mechanism of PAH in NF1 may inform the pathogenesis of PAH, NF1-PAH itself, and other NF1-associated vasculopathies. The pulmonary vasculature should now be included among the arterial beds affected by NF1 vasculopathy.
[A]:
Which is the gene mutated in type 1 neurofibromatosis?