TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Oil is a liquid fossil fuel that is extremely useful because it can be transported easily and can be used in cars and other vehicles. Oil is currently the single largest source of energy in the world. Oil from the ground is called crude oil, which is a mixture of many different hydrocarbons. Crude oil is a thick dark brown or black liquid hydrocarbon. Oil also forms from buried dead organisms, but these are tiny organisms that live on the sea surface and then sink to the seafloor when they die. The dead organisms are kept away from oxygen by layers of other dead creatures and sediments. As the layers pile up, heat and pressure increase. Over millions of years, the dead organisms turn into liquid oil. In order to be collected, the oil must be located between a porous rock layer and an impermeable layer (Figure 1.1). Trapped above the porous rock layer and beneath the impermeable layer, the oil will remain between these layers until it is extracted from the rock. Oil (red) is found in the porous rock layer (yellow) and trapped by the impermeable layer (brown). The folded structure has allowed the oil to pool so a well can be drilled into the reservoir. To separate the different types of hydrocarbons in crude oil for different uses, the crude oil must be refined in refineries like the one shown in Figure 1.2. Refining is possible because each hydrocarbon in crude oil boils at a different temperature. When the oil is boiled in the refinery, separate equipment collects the different compounds. Most of the compounds that come out of the refining process are fuels, such as gasoline, diesel, and heating oil. Because these fuels are rich sources of energy and can be easily transported, oil provides about 90% of the energy used for transportation around the world. The rest of the compounds from crude oil are used for waxes, plastics, fertilizers, and other products. Gasoline is in a convenient form for use in cars and other transportation vehicles. In a car engine, the burned gasoline mostly turns into carbon dioxide and water vapor. The fuel releases most of its energy as heat, which causes the gases to expand. This creates enough force to move the pistons inside the engine and to power the car. Refineries like this one separate crude oil into many useful fuels and other chemi- cals. Click image to the left or use the URL below. URL: The United States does produce oil, but the amount produced is only about one-quarter as much as the nation uses. The United States has only about 1.5% of the worlds proven oil reserves, so most of the oil used by Americans must be imported from other nations. The main oil-producing regions in the United States are the Gulf of Mexico, Texas, Alaska, and California (Figure As in every type of mining, mining for oil has environmental consequences. Oil rigs are unsightly (Figure 1.4), and spills are too common (Figure 1.5). Click image to the left or use the URL below. URL: Offshore well locations in the Gulf of Mex- ico. Note that some wells are located in very deep water. Drill rigs at the San Ardo Oil Field in Monterey, California.

SOLUTION: crude oil is a mixture of many different

PROBLEM: It is generally accepted that the mitochondria play central roles in energy production of most eukaryotes. In contrast, it has been thought that Plasmodium spp., the causative agent of malaria, rely mainly on cytosolic glycolysis but not mitochondrial oxidative phosphorylation for energy production during blood stages. However, Plasmodium spp. possesses all genes necessary for the tricarboxylic acid (TCA) cycle and most of the genes for electron transport chain (ETC) enzymes. Therefore, it remains elusive whether oxidative phosphorylation is essential for the parasite survival. To elucidate the role of TCA metabolism and ETC in malaria parasites, we deleted the gene for flavoprotein (Fp) subunit, Pbsdha, one of four components of complex II, a catalytic subunit for succinate dehydrogenase activity. The Pbsdha(-) parasite grew normally at blood stages in mouse. In contrast, ookinete formation of Pbsdha(-) parasites in the mosquito stage was severely impaired. Finally, Pbsdha(-) ookinetes failed in oocyst formation, leading to complete malaria transmission blockade. These results suggest that malaria parasite may switch the energy metabolism from glycolysis to oxidative phosphorylation to adapt to the insect vector where glucose is not readily available for ATP production.

SOLUTION: Which is the causative agent of malaria?

PROBLEM: Throughout its history, chronic myeloid leukemia (CML) has set precedents for cancer research and therapy. These range from the identification of the first specific chromosomal abnormality associated with cancer to the development of imatinib as a specific, targeted therapy for the disease. The successful development of imatinib as a therapeutic agent for CML can be attributed directly to decades of scientific discoveries. These discoveries determined that the BCR-ABL tyrosine kinase is the critical pathogenetic event in CML and an ideal target for therapy. This was confirmed in clinical trials of imatinib, with imatinib significantly improving the long-term survival of patients with CML. Continuing in this tradition of scientific discoveries leading to improved therapies, the understanding of resistance to imatinib has rapidly led to strategies to circumvent resistance. Continued studies of hematologic malignancies will allow this paradigm of targeting molecular pathogenetic events to be applied to many additional hematologic cancers.

SOLUTION:
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?