In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Q: Question: Indinavir is a selective inhibitor of HIV protease because: 
 Options:  <1> By hydrolysis, the active drug is generated. <2> Rents irreversibly the active center of the enzyme. <3> Its structure mimics the transition state of the reaction catalyzed by the enzyme. <4> It is a suicide inhibitor. <5> Its symmetric structure interacts effectively with the active center of the enzyme.

A: 3
****
Q: Question: What quality criteria must a psychological assessment instrument meet? 
 Options:  <1> Validity, or degree to which the scores of a test are free of measurement error. <2> Reliability, or degree to which the scores of a test are free of measurement error. <3> Have a coefficient of internal consistency above 0.40. <4> To have a low proportion of the variance observed explained by the real variance. <5> Include a high error variance.

A: 2
****
Q: Question: Patients with liver cirrhosis may have ascites due to: 
 Options:  <1> Alteration of the coagulation factors. <2> Portal hypertension and serum hypoalbuminemia. <3> Decrease in hydrostatic pressure. <4> Irritation of the peritoneal membrane by bile salts. <5> Post-surgical and abdominal trauma.

A:
2
****