In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Human bocavirus (HBoV) was recently discovered in children with respiratory distress and/or diarrhea. To our knowledge, no previous study has reported the existence of bocavirus in Saudi Arabia. Swabs samples from 80 children with respiratory tract infections were examined for the presence of HBoV. Real-time polymerase chain reaction was used as a sensitive method to detect the HBoV. Direct gene sequencing was used to determine the genotype of the detected virus isolates. HBoV was detected in 22.5% of the examined patients. The NP1 partial gene sequence from all patients showed that the circulated strains were related to HBoV-1 genotype. Most of HBoV infected patients showed evidence of mixed coinfection with other viral pathogens. The current study clearly demonstrated that genetically conserved HBoV1 circulates in Saudi Arabia. Interestingly, most of the HBoV1 infected cases were associated with high rates of co-infections with other viruses.
Detection of Bocavirus in Children Suffering from Acute Respiratory Tract Infections in Saudi Arabia

Protein microarrays are powerful tools that are widely used in systems biology research. For infectious diseases, proteome microarrays assembled from proteins of pathogens will play an increasingly important role in discovery of diagnostic markers, vaccines, and therapeutics. Distinct formats of protein microarrays have been developed for different applications, including abundance-based and function-based methods. Depending on the application, design issues should be considered, such as the need for multiplexing and label or label free detection methods. New developments, challenges, and future demands in infectious disease research will impact the application of protein microarrays for discovery and validation of biomarkers.
Protein Microarrays and Biomarkers of Infectious Disease

Aim of this study was to de termine and furthe r characte rize the se rum aminope ptidase -M in childre n with live r dise ase s. Based on our ne w assay, we have shown two fractions of the e nzyme . Activity of the ® rst fraction is e xpre sse d in undilute d se rum at pH adjuste d from 8.5 (pH of storage d se rum) to 7.4. Activity of the se cond fraction (cryptic activity) appe ars in the serum (pH 7.4) as a result of dilution and/or addition of aniline naphthale ne sulfonic acid. In childre n with Alagille syndrome , e xtrahe patic biliary duct atre sia, Byle r's dise ase , and acute hepatitis due to he patitis B virus infection, activitie s of both fractions are highly elevate d as compare d to healthy childre n or those with chronic viral he patitis. More over, se rum aminopeptidase -M se ems to re¯e ct othe r aspe cts of the pathological proce ss than those re¯ected by the alanine aminotransfe rase and g -glutamyltranspe ptidase . Due to incre ase d activity and broad substrate speci® city, the e nzyme se e ms to be also a cofactor of chole stasis and he patitis.

Further Studies on Aminopeptidase-M in Blood in Children with Cholestatic Liver Diseases and Viral Hepatitis