Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Q: Context: The immune system usually protects you from pathogens and other causes of disease. When the immune system is working properly, it keeps you from getting sick. But the immune system is like any other system of the body. It can break down or develop diseases. AIDS is an infectious disease of the immune system caused by a virus. Some diseases of the immune system are noninfectious. They include autoimmune diseases and allergies. Does it make sense for an immune system to attack the cells it is meant to protect? No, but an immune system that does not function properly will attack its own cells. An autoimmune disease is a disease in which the immune system attacks the bodys own cells. One example is type 1 diabetes. In this disease, the immune system attacks cells of the pancreas. Other examples are multiple sclerosis and rheumatoid arthritis. In multiple sclerosis, the immune system attacks nerve cells. This causes weakness and pain. In rheumatoid arthritis, the immune system attacks the cells of joints. This causes joint damage and pain. Autoimmune diseases cannot be cured. But they can be helped with medicines that weaken the immune systems attack on normal cells. Other autoimmune diseases include celiac disease (damages to the small intestine), inflam- matory bowel disease (damage to the digestive tract), psoriasis (damage to the skin), and lupus (damage to the joints, skin, kidneys, heart, and lungs). An allergy occurs when the immune system attacks a harmless substance that enters the body from the outside. A substance that causes an allergy is called an allergen. It is the immune system, not the allergen, that causes the symptoms of an allergy. Did you ever hear of hay fever? Its not really a fever at all. Its an allergy to plant pollens. People with this type of allergy have symptoms such as watery eyes, sneezing, and a runny nose. A common cause of hay fever is the pollen of ragweed. Many people are also allergic to poison ivy ( Figure 1.2). Skin contact with poison ivy leads to an itchy rash in people who are allergic to the plant. Ragweed is a common roadside weed found throughout the United States. Many people are allergic to its pollen. Some people are allergic to certain foods. Nuts and shellfish are common causes of food allergies. Other common causes of allergies include: Drugs, such as penicillin. Mold. Dust. The dead skin cells of dogs and cats, called dander. Stings of wasps and bees. Most allergies can be treated with medicines. Medicines used to treat allergies include antihistamines and corticos- teroids. These medicines help control the immune system when it attacks an allergen. Sometimes, allergies cause severe symptoms, a condition known as anaphylaxis. For example, they may cause the throat to swell so it is hard to breathe. Severe allergies may be life threatening. They require emergency medical care. 
 Question: autoimmune diseases can be cured with

A: autoimmune diseases cannot be cured.
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Q: Context: Imatinib mesylate is a new drug that can inhibit the tyrosine kinase activity of Bcr-Abl, the receptors for platelet-derived growth factor receptor(PDGF) and stem cell factor, or c-kit. Chronic myeloid leukemia (CML) is distinguished by the presence of a reciprocal translocation between chromosomes 9 and 22 that results in a shortened chromosome 22, termed the Philadelphia(Ph) chromosome. As a result of the translocation, a fusion gene called the Bcr-Abl gene is created from two normal cellular genes, encoding a chimeric Bcr-Abl protein with a deregulated tyrosine kinase activity. The expression of Bcr-Abl tyrosine kinase has been shown to be necessary and sufficient for the transformed phenotype of CML cells. Imatinib can block the kinase activity of Bcr-Abl, thus inhibiting the proliferation of Ph-positive progenitors, and has shown activity against all phases of CML, though responses are most substantial and durable in patients in the chronic phase. An international phase III study which compared the efficacy of imatinib with that of interferon alpha combined with low-dose cytarabine in newly diagnosed chronic-phase CML showed the rate of major cytogenetic response at 24 months was 90%, including 82% of complete cytogenetic response. These results indicated that imatinib was superior to interferon-containing treatment as a first-line therapy. More than 10,000 patients worldwide, including those in Japan, have been treated with imatinib in clinical trials, and a lot of information has been accumulated on the use of this drug. The aim of this article is to review the use of this drug and the practical management of patients with chronic myeloid leukemia. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

A: bcr-abl
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Q: Context: The police must investigate a series of robberies along a strip of land in the city. The new mayor of the city (Kenneth Mars) assigns Captain Harris (G.W. Bailey) and Lt. Proctor (Lance Kinsey) to the case, but while on stakeout the Wilson gang manages to slip through their fingers.The Mayor wants Harris and Proctor to work with Police Academy head Commandant Lassard (George Gaynes) on apprehending the gang. Lassard assembles a seven-man team consisting of Hightower (Bubba Smith), Tackleberry (David Graf), Jones (Michael Winslow), Hooks (Marion Ramsey), Callahan (Leslie Easterbrook), Fackler (Bruce Mahler), and Lassard's nephew, Nick (Matt McCoy) who transfers from Miami (in the previous film Police Acdemy 5) to the city to remain close to his friends and dull-witted uncle.After distributing flyers as to the information of the Wilson gang and getting nowhere, Nick McCoy stumbles upon a paper heading of an antique diamond heading to a museum, and gets an idea to use it as bait: however the robbers nab the diamond anyway by cutting a hole in the truck and escaping through the sewer system. McCoy then decides to go undercover to get information regarding a possible hideout, but Harris decides to go undercover to get a confession.It turns out that Harris goes undercover as a window washer at a tall building, for which he has a fear of heights, and gets a confession of himself on tape after his loyal but numb-skull lacky, Proctor, accidentally knocks him over the balcony.It is revealed here that the robberies are committed by a group of three dim-witted criminals who do not seem to be able to do this on their own, and it is revealed they are being guided by a literally shadow figure known as the "Mastermind", who speaks to the three behind a wall of glass and uses a voice distortion device. He devises a plan to get the cops out of the way.Commandant Lassard and his men are later suspended after stolen jewellery from the last robbery is planted in Lassard's locker, pending an investigation. The misfit cops decide to clear Lassard's name by nabbing the gang and the ringleader. Accessing data files from a computer, McCoy deduces that the robberies are occurring along a bus route, thus intentionally lowering property values in that part of the city. They also learn that someone must be 'leaking' information to the bad guys, which is why they are always one step ahead of the Police Academy.The Police Academy force finds and does battle with the Wilson gang, while Nick chases the leader. A pursuit follows, which leads to Commissioner Hurst's (George Robertson) office. It is revealed that the Mayor is the "Mastermind" and that Captain Harris has been unwittingly leaking information during his daily meetings with the Mayor. Hurst apologizes and reinstates the force, and a plaque is given to honor the officers' bravery the next day.As the movie closes, Harris is sitting in a chair when a string tying the balloon float is cut, lifting his chair and floating him up into the air as he shouts Proctor's name. 
 Question: who is guiding the group of three dimwitted criminals ?

A:
mastermind
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