Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Diabetic nephropathy is the leading cause of end-stage renal disease in humans in the Western world. The recent development of Na+-glucose cotransporter 2 (SGLT2) inhibitors offers a new antidiabetic therapy via enhanced glucose excretion. Whether this strategy exerts beneficial effects on the development of type 2 diabetic nephropathy is still largely unclear. We investigated the effects of the specific SGLT2 inhibitor empagliflozin in BTBR.Cg-Lep<ob>/WiscJ (BTBR ob/ob) mice, which spontaneously develop type 2 diabetic nephropathy. In the first experiment, BTBR ob/ob mice received either a diet containing 300 ppm empagliflozin or equicaloric placebo chow for 12 wk. In the second experiment, BTBR ob/ob mice received 1 gkg body wt(-1)day(-1) ANG II to induce arterial hypertension and were separated into the same two diet groups for 6 wk. In both experiments, empagliflozin treatment enhanced glucosuria, thereby lowering blood glucose. Independently of hypertension, empagliflozin reduced albuminuria in diabetic mice. However, empagliflozin treatment affected diabetes-related glomerular hypertrophy, markers of renal inflammation, and mesangial matrix expansion only in BTBR ob/ob mice without hypertension. In summary, empagliflozin demonstrated significant antihyperglycemic effects, differentially ameliorating early features of diabetic nephropathy in BTBR ob/ob mice with and without hypertension.

Answer: Which protein does empagliflozin inhibit?


Question: Community-acquired pneumonia (CAP) is a common cause of morbidity and mortality in adults worldwide, but its epidemiology varies markedly by region. Whilst in high-income countries, the predominant burden of CAP is in the elderly and those with chronic cardiovascular and pulmonary co-morbidity, CAP patients in low-income settings are often of working age and, in sub-Saharan Africa, frequently HIV-positive. Although region-specific aetiological data are limited, they are sufficient to highlight major trends: in high-burden settings, tuberculosis (TB) is a common cause of acute CAP; Gram-negative pathogens such as Klebsiella pneumoniae are regionally important; and HIV-associated opportunistic infections are common but difficult to diagnose. These differences in epidemiology and aetiological profile suggest that modified approaches to diagnosis, severity assessment and empirical antimicrobial therapy of CAP are necessary, but tailored individualized management approaches are constrained by limitations in the availability of radiological and laboratory diagnostic services, as well as medical expertise. The widespread introduction of the Xpert MTB/RIF platform represents a major advance for TB diagnosis, but innovations in rapid diagnostics for other opportunistic pathogens are urgently needed. Severity assessment tools (e.g. CURB65) that are used to guide early management decisions in CAP have not been widely validated in low-income settings and locally adapted tools are required. The optimal approach to initial antimicrobial therapy choices such as the need to provide early empirical cover for atypical bacteria and TB remain poorly defined. Improvements in supportive care such as correcting hypoxaemia and intravenous fluid management represent opportunities for substantial reductions in mortality.

Answer: CURB65 score is used for stratification of which disease?


Question: Love Canal gained worldwide attention in the late 1970s when the press started covering its story. The story is outlined below and illustrated in Figure 19.9. The Love Canal disaster actually began back in the mid 1900s. The disaster continues even today. Starting in the early 1940s, a big chemical company put thousands of barrels of chemical waste into an old canal. Over the next 10 years, the company dumped almost 22,000 tons of chemicals into the ground! In the early 1950s, the company covered over the barrels in the canal with soil. Then they sold the land to the city for just a dollar. The city needed the land in order to build an elementary school. The company warned the city that toxic waste was buried there. But they thought the waste was safe. The school and hundreds of homes were also built over the old canal. As it turned out, the cheap price was no bargain. Chemicals started leaking from the barrels. Chemicals seeped into basements. Chemicals bubbled up to the surface of the ground. In some places, plants wouldnt even grow on the soil. People noticed bad smells. Many got sick, especially the children. Residents wanted to know if the old chemicals were the cause. But they had a hard time getting officials to listen. So they demonstrated and demanded answers. Finally, the soil was tested and was found to be contaminated with harmful chemicals. For example, it contained a lot of lead and mercury. Both can cause permanent damage to the human nervous system. The school was closed. More than 200 homes were evacuated. Much of the Love Canal neighborhood was bulldozed away. The area had a massive clean-up effort. The cleanup cost millions of dollars. More than three decades later, much of Love Canal is still too contaminated to be safe for people. Love Canal opened peoples eyes to toxic waste burial. They realized there must be other Love Canals all over the country. Thousands of contaminated sites were found. The Superfund Act was passed in 1980. The law required that money be set aside for cleanup of toxic waste sites, like the Elizabeth Copper Mine in Vermont (see the far-right image in Figure 19.9). The law also required safer disposal of hazardous waste in the future. Love Canal highlighted the problem of pollution by hazardous waste. Hazardous waste is any waste that is dangerous to the health of people or the environment. It may be dangerous because it is toxic, corrosive, flammable, or explosive. Toxic waste is poisonous. Toxic waste may cause cancer or birth defects in people. It may also harm other living things. Corrosive waste is highly reactive with other substances. Corrosive waste may cause burns or destroy other materials that it touches. Flammable waste can burn easily. It may also give off harmful fumes when it burns. Explosive waste is likely to explode. The risk of explosion may be greater if the waste is mixed with other substances. Table 19.1 shows some examples of hazardous waste. Look closely. Are any of these examples lurking around your home? Example Description Cars contain toxic fluids such as brake fluid. The fluids may also be corrosive and flammable. This photo shows one way the fluids can end up in the ground. Cars use gas and oil. These materials are toxic and flammable. They pollute the land when they leak or spill. Batteries contain toxic and corrosive materials. People often toss them in the trash, but they should be disposed of properly. Electronics, such as old computers, contain toxic chem- icals. They may be sent to landfills where the toxic materials end up in the ground. Medical waste can contain many hazards: Human body fluids may cause disease; old thermometers may contain toxic mercury; and pharmaceuticals may be toxic to people and other living things. Example Description Paints can be both toxic and flammable. Paints may spill on the ground or be thrown improperly in the trash. Chemicals are applied to farm fields and lawns. They include fertilizers, herbicides, and pesticides. Many of these chemicals are toxic to people and other animals. The greatest source of hazardous waste is industry. Agriculture is another major

Answer:
Nations that produce the most hazardous waste have the most