Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: Imatinib mesylate is a new drug that can inhibit the tyrosine kinase activity of Bcr-Abl, the receptors for platelet-derived growth factor receptor(PDGF) and stem cell factor, or c-kit. Chronic myeloid leukemia (CML) is distinguished by the presence of a reciprocal translocation between chromosomes 9 and 22 that results in a shortened chromosome 22, termed the Philadelphia(Ph) chromosome. As a result of the translocation, a fusion gene called the Bcr-Abl gene is created from two normal cellular genes, encoding a chimeric Bcr-Abl protein with a deregulated tyrosine kinase activity. The expression of Bcr-Abl tyrosine kinase has been shown to be necessary and sufficient for the transformed phenotype of CML cells. Imatinib can block the kinase activity of Bcr-Abl, thus inhibiting the proliferation of Ph-positive progenitors, and has shown activity against all phases of CML, though responses are most substantial and durable in patients in the chronic phase. An international phase III study which compared the efficacy of imatinib with that of interferon alpha combined with low-dose cytarabine in newly diagnosed chronic-phase CML showed the rate of major cytogenetic response at 24 months was 90%, including 82% of complete cytogenetic response. These results indicated that imatinib was superior to interferon-containing treatment as a first-line therapy. More than 10,000 patients worldwide, including those in Japan, have been treated with imatinib in clinical trials, and a lot of information has been accumulated on the use of this drug. The aim of this article is to review the use of this drug and the practical management of patients with chronic myeloid leukemia.
Example Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

Example Input: You're in your office when you learn there's someone with a gun wandering outside. You can hear gunshots and screams. What do you do? That's the challenge for users of a new virtual reality program called SurviVR, designed to train employees how to deal with an active shooter situation in the workplace. The program works with HTC Vive, the virtual reality headset released earlier this year. An active shooter situation is when an armed person or people actively shoot in a small, populated area with the intention to kill. There were 20 such situations in the United States last year and 20 the year before, according to FBI statistics, resulting in a total of 231 deaths. This year saw the deadliest active shooter situation in US history , with 49 people killed in a nightclub in Orlando. In the training situation, users have four choices. They can lock themselves in the office. They can hide, perhaps in the office closet. They can run for an exit. Or they can use something in the office--a computer or a cup a pair of scissors-as a weapon to fight the shooter. This is an improvement on standard active shooter training. Gallo says, which typically teachers people to lock themselves in place and hide. The "lock down" method is often ineffective, he says, and has resulted in many deaths in recent years. In the training's basic level, no one gets killed. But as the trainings become more advanced, players who make a wrong choice be shot. There's no blood; the screen simply turns black slowly. If this sounds terrifying, that's the point, says Gallo. There are plenty of training programs to teach employees how to deal with workplace violence, sometimes involving role play with toy guns. But these trainings are basically games. Gallo says, with employees relaxed and even enjoying themselves. To teach people what they really need to know for an active shooter situation, they need to be scared. "SurviVR will take the fear and turn it into confidence." Gallo says.
Example Output: What does Gallo think of the training programs involving role play with toy guns?

Example Input: Private investigator Patrick Kenzie (Casey Affleck) and his partner/girlfriend Angie Gennaro (Michelle Monaghan) witness a televised plea by a woman named Helene McCready (Amy Ryan) for the return of her missing daughter Amanda, who was abducted with her favorite doll "Mirabelle". Patrick and Angie are then hired by the child's aunt Beatrice (Amy Madigan) to find Amanda and discover that Helene and her boyfriend "Skinny Ray" (Sean Malone) had recently stolen money from Cheese (Edi Gathegi), a local Haitian drug lord. After Ray is murdered, Patrick and Angie join the police detectives Remy Bressant (Ed Harris) and Nick Poole (John Ashton) with investigating the case and assist in arranging the trade of money for the return of Amanda. Captain Jack Doyle (Morgan Freeman) reads Patrick a telephone transcript of the drug lord setting up an exchange for Amanda. The exchange at a nearby quarry in Quincy is botched and it is believed Amanda drowned; her doll is found in the quarry and returned to Helene. Doyle, whose own daughter was killed years before, takes responsibility for the death and goes into early retirement. Two months later, a seven year old boy is abducted in Everett and Patrick receives information that the boy was taken by a known child molester. After entering the suspect's house and finding evidence of the abducted boy, Patrick returns with Remy and Nick to rescue him. They are seen by the residents and Nick is shot. Patrick enters the house during the shootout and finds one of the residents dead. He retreats into the child molester's room, where he finds the boy's dead body; he then shoots the child molester in the back of the head in a fit of rage. Nick later dies of his wounds. Trying to alleviate Patrick's guilt over the events at the house, Remy unthinkingly confides that he once planted evidence on someone with the help of "Skinny Ray" whom he had initially told Patrick he didn't know. After Nick's funeral, Patrick speaks to a police officer, who tells him that Remy had been asking about the drug lord's stolen money before the drug lord knew it was missing. Patrick then questions Beatrice's husband Lionel (Titus Welliver) in a bar and pieces together that Lionel and Remy had conspired to stage a fake kidnapping in order to take the drug money for themselves and to take Amanda from her neglectful mother's care. At that point, Remy (trying to cover for his earlier mistake) enters the bar, while wearing a latex mask and holding a shotgun, and stages a robbery. He points the shotgun at Lionel's head, but the bartender shoots Remy twice in the back. Remy flees and is pursued by Patrick to the rooftop of a nearby building, where he dies. Patrick is questioned by the police about Remy's death and learns that the police never had a phone transcript like the one that Doyle had read to him prior to the botched exchange. Patrick and Angie drive to Doyle's home, where Patrick finds Amanda living with Doyle and his wife; Doyle was part of the phony kidnapping all along. Patrick threatens to call the authorities, but Doyle attempts to convince him that Amanda is better off living with them than with her mother, and that is reason enough not to get involved. Patrick leaves and discusses the choices with Angie, who says she will leave him if he calls the police, since she also believes Amanda is much better off with the Doyles. In the next scene, the police arrive, Doyle is arrested, Amanda is returned to her mother amidst heavy publicity, and Patrick and Angie break up. Patrick later visits Amanda as Helene is about to leave on a date with someone she met during the publicity over her daughter's disappearance. Helene informs Patrick that Beatrice has been forbidden to visit and is upset about her husband's arrest. Helene has no babysitter for Amanda and when asked, she tells Patrick that Helene's friend, Dottie (Jill Quigg) will watch her, even though she has yet to ask Dottie herself. Patrick volunteers to watch Amanda, who is holding her
Example Output:
Where was Amanda found?