Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Researchers from France and Italy discovered that Canadian parents are less strict with their children than mothers and fathers in France and Italy. "Our most important finding was the difference between Canadians and the others," said Professor Michel Claes,the lead author of the study."Canadians focus on independence and negotiation.On the other hand,Italians,for example,exercise more control.We found Canadians seem to focus on negotiation in case of a conflict." Claes said Canada,France and Italy were selected for the study because they share important cultural and social factors."We chose FrenchCanadians because they share the same language as France,and originally came from France and share certain values.Italy was included because it was considered to have similar,strong and important family values," he explained. The researchers examined the emotional ties between parents and their children by questioning 1,256 students aged 11 to 19 years old. Canadian students reported less control and more free actions,according to the study.Italian parents were stricter and French parents were somewhere in the middle. Claes explains that the differences lie in education in Canada,France and Italy. "North America has its own educational values,which promote individualization.Tolerance and comprehension are encouraged.Italy,on the other hand,promotes respect of authority,control,and the need for permission." he said. Children from all three countries described their mothers as warm and communicative.Italian and Canadian children had similar feelings about their fathers,and reported high levels of emotional ties.But French fathers were generally thought by their children to be more distant and cold. "We were surprised by this," Claes admitted."It seems as though the relationships between French mothers and their children were becoming closer over time,while fathers maintain a form of distance and coldness,which is more of a source of conflict in France than in the other countries."

Answer: According to Michel Claes,what mainly leads to the differences in parentchildren relationships among Canada,France and Italy?


Question: Chronic myeloid leukemia (CML) is arguably the best understood of all human malignancies. Its origins in the hematopoietic stem cell can be traced to a reciprocal translocation involving chromosomes 9 and 22, dubbed the Philadelphia chromosome, which is observed in essentially all patients. The resulting fusion gene, BCR/ABL, encodes an activated tyrosine kinase that can act alone to induce a CML-like syndrome in mouse models. These animal models have validated BCR/ABL as a target for the development of specific pharmaceutical inhibitors. The kinase inhibitor imatinib mesylate (Gleevec) is highly specific, effective, and minimally toxic, but may not effect cures as a single agent, particularly in patients with accelerated and blast-phase disease. Resistance to imatinib can confound therapy. Surprisingly, a high percentage of resistant cases manifest intact or augmented BCR/ABL signaling, suggesting that this oncoprotein, or signaling pathways emanating from it, remain viable targets. Combination chemotherapy is under active investigation, and among the most compelling strategies is dual treatment with agents that both target BCR/ABL signal transduction. BCR/ABL activates Ras, and compounds designed to antagonize Ras function called farnesyl transferase inhibitors (FTIs) have shown potent activity in vitro and in animal models of BCR/ABL-induced leukemia. Initial clinical trials in patients with refractory acute myeloid leukemia and CML in blast crisis have shown significant activity, suggesting that trials combining imatinib and FTIs are warranted.

Answer: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Question: Phthiriasis palpebrarum is an uncommon cause of blepharoconjunctivitis in which Pthirus pubis infest the eyelashes. We report a case of unilateral phthiriasis palpebrarum with crab louse. A 45-year-old man presented with conjunctival hyperaemia and moderate itching associated with irritation, and crusty excretions of the eyelashes in the left eye. Careful slit-lamp examination revealed many lice and nits in left eye and mild conjunctival hyperaemia. No abnormality was found in the right eye. On dermatologic examination, only one louse was found at the pubic area. The patient was treated effectively with petrolatum jelly (Vaseline) and 1% permethrin shampoo (Kwellada 1% shampoo). At the end of the first week no louse or nit was present on eyelashes and pubic area.

Answer:
What is the cause of Phthiriasis Palpebrarum?