Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: Spleen tyrosine kinase (SYK) has come into focus as a potential therapeutic target in chronic inflammatory diseases, such as rheumatoid arthritis and asthma, as well as in B-cell lymphomas. SYK has also been involved in the signaling of immunoreceptors, cytokine receptors, and integrins. We therefore hypothesized that inhibition of SYK attenuates the inflammatory process underlying atherosclerosis and reduces plaque development. Low-density lipoprotein receptor-deficient mice consuming a high-cholesterol diet supplemented with 2 doses of the orally available SYK inhibitor fostamatinib for 16 weeks showed a dose-dependent reduction in atherosclerotic lesion size by up to 596% compared with the respective controls. Lesions of fostamatinib-treated animals contained fewer macrophages but more smooth muscle cells and collagen-characteristics associated with more stable plaques in humans. Mechanistically, fostamatinib attenuated adhesion and migration of inflammatory cells and limited macrophage survival. Furthermore, fostamatinib normalized high-cholesterol diet -induced monocytosis and inflammatory gene expression. We present the novel finding that the SYK inhibitor fostamatinib attenuates atherogenesis in mice. Our data identify SYK inhibition as a potentially fruitful antiinflammatory therapeutic strategy in atherosclerosis. 
 Question: Which enzyme is inhibited by a drug fostamatinib?
spleen tyrosine kinase

Context: After Alaungpaya's death, the new Burmese king Naungdawgyi was embroiled in several rebellions, including that of Gen. Minkhaung Nawrahta, and could not resume the war. The war was inconclusive. For all their work, the Burmese gained little of their original objectives. Siam very much remained a thorn to the stability of Burmese peripheral regions. In the following years, Siam continued to provide support to Mon rebels in the south who raised a major rebellion in 1762 as well as those in Lan Na in the north . The only lasting territorial gain the Burmese achieved was the upper Tenasserim coast, on which they previously had only a nominal claim. Although the Siamese troops no longer openly intruded the border, the Mon rebels continued to operate from the Siamese territory. In 1764, the Mon governor of Tavoy, who was made governor by Alaungpaya only four years earlier, revolted until it was put down in November 1764. Likewise, the instabilities in Lan Na resumed soon after the Burmese army left in February 1764, forcing the army to return again later in the year. The inconclusive nature of the war would lead to the next war in 1765. 
 Question: hich happened first, the nominal claim of the Burmese on the Tenasserim coast, or a territorial claim?
a nominal claim

Context: Rose Elliot (Irene Miracle), a poet living alone in New York City, discovers an ancient book called The Three Mothers. It tells of the existence of three evil sisters who rule the world with sorrow, tears, and darkness. The book, written by an architect named Varelli, reveals that the three dwell inside separate homes that had been specially designed and built for them by the architect in Rome, Freiburg, and New York. Rose suspects that she is living in one of the buildings and writes to her brother Mark (Leigh McCloskey), a music student in Rome, urging him to visit her. Using clues provided in Varelli's book as a guide, Rose searches the cellar of her building and discovers a hole in the floor which leads to a water-filled ballroom. After accidentally dropping her keys into the water, she enters the flooded room. Swimming under the surface, she sees a portrait bearing the words "Mater Tenebrarum" and is able to reclaim the keys. A putrid corpse suddenly rises from the depths, frightening her. She escapes, although a shadowy figure watches her leave the basement.In Rome, Mark attempts to read Rose's letter during class. He is distracted by the intense gaze of a beautiful student (Ania Pieroni). When the class ends she leaves suddenly; Mark follows, leaving the letter behind. His friend Sara (Eleonora Giorgi) picks up the letter, and eventually reads it. Horrified by the letter's contents, she takes a taxi to a library and locates a copy of The Three Mothers. While looking for an exit, Sara is attacked by a monstrous figure who recognizes the book. She throws the book to the ground and escapes. Later that night, she seeks the company of a neighbor named Carlo (Gabriele Lavia) and both are stabbed to death by a gloved killer. Mark discovers the bodies and two torn fragments from Rose's letter. After the police arrive, he walks out of Sara's apartment and sees a taxi slowly driving by. In it is the music student, staring at him intently once again.Mark telephones Rose but is unable to hear her clearly. He promises to visit just before the connection fails. Cut off, Rose sees two shadowy figures preparing to enter her apartment. She leaves through a back door, but is followed. In a decrepit room, she is grabbed from behind by a clawed assailant and brutally murdered.Upon arriving in New York, Mark meets some of the residents of Rose's building, including a nurse (Veronica Lazar) who is caring for the elderly Professor Arnold (Feodor Chaliapin, Jr.), a wheelchair-bound mute. Mark learns from the sickly Countess Elise (Daria Nicolodi) that Rose has disappeared. Elise explains how Rose had been acting strangely. After the two find blood on the carpet outside Rose's room, Mark follows the stains. He suddenly becomes ill and falls unconscious. Elise sees a black-robed figure dragging Mark away, but the figure suddenly stops and gives chase to Elise. She is attacked by dozens of cats, who bite and claw at her flesh. The hooded figure then stabs her to death. Mark staggers to the house's foyer where the nurse and caretaker (Alida Valli) put him to bed.The next day, Mark asks Kazanian (Sacha Pitoeff), the antique dealer who sold Rose the Three Mothers book, about Rose. However, the man provides no information. That night, Kazanian drowns several cats in a Central Park pond and accidentally falls into the water. Hundreds of rats from a nearby drain crawl all over him, gnawing his flesh. A hot dog vendor hears Kazanian's cries and rushes over. The man kills Kazanian with a knife.Carol, the caretaker, discovers the horribly mutilated corpse of Elise's butler (Leopoldo Mastelloni) in the Countess' apartment. Shocked, she drops a lit candle which starts a fire. Attempting to put out the flames, she becomes entangled in burning draperies and falls from a window to her death.Meanwhile, Mark uses a clue from Rose's letter to discover that beneath each floor is a secret 
 Question: Who is Rose's brother?

matthew, mark, luke, and bing.