TASK DEFINITION: Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
PROBLEM: Context: Lorenzo Ricci, S.J. (August 1, 1703 -- November 24, 1775) was an Italian Jesuit, elected the 18th Superior General of the Society of Jesus. 
 Question: What group was Lorenzo Ricci a member of?

SOLUTION: society of jesus

PROBLEM: Context: A rock is a naturally formed, non-living Earth material. Rocks are made of collections of mineral grains that are held together in a firm, solid mass (Figure 1.1). How is a rock different from a mineral? Rocks are made of minerals. The mineral grains in a rock may be so tiny that you can only see them with a microscope, or they may be as big as your fingernail or even your finger (Figure Rocks are identified primarily by the minerals they contain and by their texture. Each type of rock has a distinctive set of minerals. A rock may be made of grains of all one mineral type, such as quartzite. Much more commonly, rocks are made of a mixture of different minerals. Texture is a description of the size, shape, and arrangement of mineral grains. Are the two samples in Figure 1.3 the same rock type? Do they have the same minerals? The same texture? The different colors and textures seen in this rock are caused by the presence of different minerals. A pegmatite from South Dakota with crystals of lepidolite, tourmaline, and quartz (1 cm scale on the upper left). Sample 2 Crystals are tiny or microscopic Magma erupted and cooled quickly Andesite As seen in Table 1.1, these two rocks have the same chemical composition and contain mostly the same minerals, but they do not have the same texture. Sample 1 has visible mineral grains, but Sample 2 has very tiny or invisible grains. The two different textures indicate different histories. Sample 1 is a diorite, a rock that cooled slowly from magma (molten rock) underground. Sample 2 is an andesite, a rock that cooled rapidly from a very similar magma that erupted onto Earths surface. A few rocks are not made of minerals because the material they are made of does not fit the definition of a mineral. Coal, for example, is made of organic material, which is not a mineral. Can you think of other rocks that are not made of minerals? Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL: 
 Question: _______________________ is a naturally formed, non-living earth material.

SOLUTION: rock

PROBLEM: Context: The reactive oxygen-generating NADPH oxidases (Noxes) function in a variety of biological roles, and can be broadly classified into those that are regulated by subunit interactions and those that are regulated by calcium. The prototypical subunit-regulated Nox, Nox2, is the membrane-associated catalytic subunit of the phagocyte NADPH-oxidase. Nox2 forms a heterodimer with the integral membrane protein, p22phox, and this heterodimer binds to the regulatory subunits p47phox, p67phox, p40phox and the small GTPase Rac, triggering superoxide generation. Nox-organizer protein 1 (NOXO1) and Nox-activator 1 (NOXA1), respective homologs of p47phox and p67phox, together with p22phox and Rac, activate Nox1, a non-phagocytic homolog of Nox2. NOXO1 and p22phox also regulate Nox3, whereas Nox4 requires only p22phox. In this study, we have assembled and analyzed amino acid sequences of Nox regulatory subunit orthologs from vertebrates, a urochordate, an echinoderm, a mollusc, a cnidarian, a choanoflagellate, fungi and a slime mold amoeba to investigate the evolutionary history of these subunits. Ancestral p47phox, p67phox, and p22phox genes are broadly seen in the metazoa, except for the ecdysozoans. The choanoflagellate Monosiga brevicollis, the unicellular organism that is the closest relatives of multicellular animals, encodes early prototypes of p22phox, p47phox as well as the earliest known Nox2-like ancestor of the Nox1-3 subfamily. p67phox- and p47phox-like genes are seen in the sea urchin Strongylocentrotus purpuratus and the limpet Lottia gigantea that also possess Nox2-like co-orthologs of vertebrate Nox1-3. Duplication of primordial p47phox and p67phox genes occurred in vertebrates, with the duplicated branches evolving into NOXO1 and NOXA1. Analysis of characteristic domains of regulatory subunits suggests a novel view of the evolution of Nox: in fish, p40phox participated in regulating both Nox1 and Nox2, but after the appearance of mammals, Nox1 (but not Nox2) became independent of p40phox. In the fish Oryzias latipes, a NOXO1 ortholog retains an autoinhibitory region that is characteristic of mammalian p47phox, and this was subsequently lost from NOXO1 in later vertebrates. Detailed amino acid sequence comparisons identified both putative key residues conserved in characteristic domains and previously unidentified conserved regions. Also, candidate organizer/activator proteins in fungi and amoeba are identified and hypothetical activation models are suggested. This is the first report to provide the comprehensive view of the molecular evolution of regulatory subunits for Nox enzymes. This approach provides clues for understanding the evolution of biochemical and physiological functions for regulatory-subunit-dependent Nox enzymes. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?

SOLUTION:
nadph oxidase 1