instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: Spleen tyrosine kinase (SYK) has come into focus as a potential therapeutic target in chronic inflammatory diseases, such as rheumatoid arthritis and asthma, as well as in B-cell lymphomas. SYK has also been involved in the signaling of immunoreceptors, cytokine receptors, and integrins. We therefore hypothesized that inhibition of SYK attenuates the inflammatory process underlying atherosclerosis and reduces plaque development. Low-density lipoprotein receptor-deficient mice consuming a high-cholesterol diet supplemented with 2 doses of the orally available SYK inhibitor fostamatinib for 16 weeks showed a dose-dependent reduction in atherosclerotic lesion size by up to 596% compared with the respective controls. Lesions of fostamatinib-treated animals contained fewer macrophages but more smooth muscle cells and collagen-characteristics associated with more stable plaques in humans. Mechanistically, fostamatinib attenuated adhesion and migration of inflammatory cells and limited macrophage survival. Furthermore, fostamatinib normalized high-cholesterol diet -induced monocytosis and inflammatory gene expression. We present the novel finding that the SYK inhibitor fostamatinib attenuates atherogenesis in mice. Our data identify SYK inhibition as a potentially fruitful antiinflammatory therapeutic strategy in atherosclerosis. 
 Question: Which enzyme is inhibited by a drug fostamatinib?
answer:
spleen tyrosine kinase


question:
Context: In America, when the eighth graders leave the middle school, they are often worried about moving to the high school. It is a hard time for them, but it can be an exciting one as well. To make it easier, students need to get familiar with their school. Even though they've done this already in the middle school, it's still important to find where their classrooms are. Most schools take students to the high school for a visit at the end of their eighth grade year. And, most schools also have a freshman speech for parents and students before the first year begins. Sometimes the main office will give away a map of the school. This can help students and parents to find different places in the school. One way to know your high school more and make new friends is to join a club or play a sport. Schools often offer chances to join different clubs and sports. Fall activities begin in August before the first day of school. If you are not interested in sports, there are clubs for any interest, such as drama, dance, chess, photography, community service, etc. These clubs allow students from different grades. By joining an activity, students can find new friendships, not to mention improving their chances in future college applications . The school office will have a list of activities offered at the school and information on how to join them. What's more, to have a great start to a high school year, students can write down some of their worries, and ask for help from teachers and school workers. 
 Question: When do many schools take students to visit their new high school?
answer:
at the end of their eighth grade year


question:
Context: Over the next year, however, the Polish forces were subject to attrition, as the Sejm again refused to raise taxes and pay the army, resulting in mass desertions of unpaid soldiery. The Polish problems were further aggravated by the incompetent leadership of hetman Micha Kazimierz Pac, who obstructed Sobieski's leadership, while the Ottomans continued to receive reinforcements. Nonetheless in 1674 the Commonwealth resumed the offensive, taking advantage of a new Muscovy-Ottoman conflict that year, and the Polish-Ottoman war remained undecided.:275 Sobieski's force of 6,000 defeated 20,000 Turks and Tatars under Ibrahim Shyshman in the battle of Lwow in August 1675.:653 Even after the Battle of Trembowla, the Sejm still refused his pleas for more funds and a larger army.:653 In 1676, after Sobieski's 16,000 withstood the two-week siege of Zurawno, by 100,000 men under Ibrahim Pasha, a new peace treaty was signed, the Treaty of Zurawno.:655 The peace treaty partially reversing those from Buczacz: the Ottomans kept approximately two thirds of the territories they gained in 1672, and the Commonwealth no longer was obliged to pay any kind of tribute to the Empire; a large number of Polish prisoners were released by the Ottomans. 
 Question: Which leader had fewer fighters in the battle of Lwow?
answer:

sobieski