In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Example Input: Question: In a determination of the activity of an enzyme, the depletion of the substrate: 
 Options:  <1> It is essential for most trials. <2> It may give falsely low results in sera with high enzymatic activity. <3> It occurs when the reagent is finished. <4> It occurs due to a defect in the spectrophotometer. <5> It can lead to falsely elevated results in sera with high enzymatic activity.
Example Output: 2

Example Input: Question: One of the characteristics of the primary delirium experience is: 
 Options:  <1> Its greater modifiability, compared with the secondary one. <2> The primary obsessive concern of the patient to control reality. <3> That does not have its origin in a previous anomalous experience. <4> That is not maintained with intense conviction. <5> Which is plausible
Example Output: 3

Example Input: Question: A 75-year-old man who reported decreased visual acuity in his right eye of two weeks of evolution. In the fundus examination, soft drusen and serous detachment at the level of the macula are seen. What treatment is currently the most indicated for this disease? 
 Options:  <1> Focal photocoagulation with laser. <2> Photodynamic therapy. <3> Intravitreal injections of anti-angiogenic drugs. <4> Posterior vitrectomy. <5> Observation.
Example Output:
3