Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: Gregory A. Feest (born 1956) is a United States Air Force Air Force major general who is currently serving as the Chief of Safety of the United States Air Force, Headquarters U.S. Air Force, Washington, D.C., and Commander, Air Force Safety Center, Kirtland Air Force Base, New Mexico.
[EX A]: What military branch did Gregory A. Feest belong to?

[EX Q]: The following five destination shall never be missed *Blue Lagoon : Blue Lagoon geothermal spa is one of the most visited attractions in Iceland. The warm waters are rich in minerals and bathing in the Blue Lagoon is reputed to help some people suffering from skin diseases. The water temperature in the bathing and swimming area of the Lagoon averages 37degC - 39degC(99F -102F). The Blue Lagoon also operates a research and development facility to help find cures for skin diseases using the mineral-rich water. *Budapest: Budapest holds the title "City of Spas" since the year 1934, as it has more hot and medicinal water springs than any other capital city in the world. There are 118 springs in Budapest, providing over 70 million liters of hot water a day. The temperature of the waters is between 22degC and 40degC. *El Tatio: El Tatio is a geyser field located within the Andes Mountains of northern Chile at 4,320 meters above sea level. With over 80 active geysers, the site is the largest geyser field in the southern hemisphere and the third largest in the world. It is a major tourist attraction in Chile and is among the highest-elevation geyser fields in the world. The temperature of the waters goes between 70degC and 85degC. *Hokkaido: Visitors to the Japanese island of Hokkaido have plenty of options. These range from top resorts with thermal baths like the Spa Resort Hawaiians to small traditional inns that have their own small hot pools with water temperature comfortable to skin. Some bathing spots are outdoors and are not associated with any spa or inn. The classic forest and mountain landscapes of this nature-rich island make it a great choice for those seeking a science setting for their baths.
[EX A]: Which site of the spring has the greatest gap of water temperature?

[EX Q]: Recently mutations in the gene ZFHX1B (SIP1) were shown in patients with "syndromic Hirschsprung disease" with mental retardation (MR) and multiple congenital anomalies (MCA), but it was unclear if Hirschsprung disease is an obligate symptom of these mutations and if the distinct facial phenotype delineated by Mowat et al. [1998: J Med Genet 35: 617-623] is specific for ZFHX1B mutations. In order to address these open questions we analyzed the ZFHX1B gene in five patients, three of whom had "syndromic Hirschsprung disease" two with and one without the facial phenotype described by Mowat et al. [1998], and two of whom had the distinct facial gestalt without Hirschsprung disease. Analyses of microsatellite markers and newly identified SNPs, and/or FISH with BACs from the ZFHX1B region excluded large deletions in all five patients. Direct sequencing demonstrated truncating ZFHX1B mutations in all four patients with the characteristic facial phenotype, but not in the patient with syndromic Hirschsprung disease without the distinct facial appearance. We demonstrate that there is a specific clinical entity with a recognizable facial gestalt, mental retardation and variable MCAs which we propose be called the "Mowat-Wilson syndrome."
[EX A]:
Which gene is responsible for the development of the Mowat-Wilson syndrome?