TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Protein kinases (PKs) and lipid kinases (LKs) are good choices for targets of signal transduction therapy as these enzymes are involved in signaling pathways, and are often related to the pathogenesis of lymphoid malignancies. The attractiveness of PKs and LKs as drug able targets is enhanced by the fact that they are enzymes whose biological activity can be turned off by drugs that block their catalytic site. In the last few years small molecular kinase inhibitors (KIs) have been synthesized and become available for preclinical studies and clinical trials. The first KI, introduced into clinical practice in 1998, was imatinib mesylate, which became the first choice drug in chronic myeloid leukemia. More recently, several KIs have been developed to target the proximal B-cell receptor (BCR) signaling pathway including spleen tyrosine kinase inhibitor (Fostamatinib) and Bruton's tyrosine kinase inhibitors (Ibrutinib, AVL-263). These agents are currently evaluated in early clinical trials in chronic lymphocytic leukemia (CLL) and other diseases. Cyclin-dependent kinase (Cdk) inhibitors, flavopiridol (alvocidib), BMS-387032 (SNS-032), sunitinib and sorafenib are currently under evaluation in clinical trials for relapsed/refractory CLL. Multi-tyrosine kinase inhibitors including vandetanib (ZD6474) bosutinib (SKI-606), TKI258 (CHIR-258), pazopanib (GW786034) and axitinib (AG013736) have been also developed for the treatment of lymphoid malignancies. Phosphatidylinositol 3-kinases (PI3K ) are a family of lipid kinases that mediate signals from cell surface receptors. CAL-101 (GS-1101) is an oral PI3K-specific inhibitor which has shown preclinical and clinical activity against CLL. This article summarizes recent achievements in the mechanism of action, pharmacological properties and clinical activity and toxicity of PK and LK inhibitors in CLL.

SOLUTION: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?

PROBLEM: Phoebe Campbell (c. 1847 -- 20 June 1872) was a Canadian woman who was hanged for the murder of her husband.

SOLUTION: Which crime Phoebe Campbell is considered to have commited?

PROBLEM: The Royal Mint has chosen Beatrix Potter's thieving Peter Rabbit as the first character from children's literature ever to appear on a UK coin. Peter, pictured in the blue jacket that he is forced to abandon in the garden of Mr McGregor when he is caught stealing vegetables, is captured on a special, coloured edition of a 50p coin available from now. The Royal Mint, which described Peter as "the most recognizable of Potter's creations, and one of the most cherished from children's literature", will release uncoloured versions of the coin in change later this year. Three more of Potter's characters will also be committed to currency later this year, as part of celebrations marking 150 years since the children's author's birth. The images have been created by coin designer Emma Noble, who said it was "amazing to be given the opportunity to work with such famous and treasured literary characters". Potter's The Tale of Peter Rabbit, featuring Peter and his better-behaved siblings Flopsy, Mopsy and Cottontail, was the first of her stories to be published, released in 1902 by Frederick Warne & Co. Potter would go on to follow it with a series of much-loved stories which remain popular today, from The Tale of Squirrel Nutkin to The Tale of Jemima Puddle-Duck.

SOLUTION:
Which character from children's literature can be found on the UK coin?