In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Ex Input:
Question: A plasmid contains necessarily: 
 Options:  <1> Genes of resistance to antibiotics. <2> Origin of replication. <3> Integrons <4> Genes of transfer by conjugation. <5> Transposons.

Ex Output:
2


Ex Input:
Question: In the receptor-mediated endocytosis intervenes: 
 Options:  <1> Only the clathrin. <2> Only the adaptin. <3> Adaptine and clathrin. <4> Chaperones <5> Only the proteins of the membrane.

Ex Output:
3


Ex Input:
Question: The carcinogenic action of Benzo (a) pyrene: 
 Options:  <1> It is due to the production of oxygen free radicals. <2> It is due to its biotransformation in a dihydrodiol. <3> It is due to its biotransformation in an epoxide. <4> It increases in tissues rich in epoxide hydrolase. <5> It diminishes in tissues rich in cytochrome P450.

Ex Output:

3