instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: They Met in Argentina is a 1941 American film, directed by Leslie Goodwins and Jack Hively for RKO Pictures, Hively had to come in and finish the picture after Goodwins was hospitalized for pneumonia. 
 Question: What was the name of the director for They Met in Argentina?
answer:
leslie goodwins


question:
Context: The selective degradation of cytosolic proteins in lysosomes by chaperone-mediated autophagy depends, at least in part, on the levels of a substrate receptor at the lysosomal membrane. We have previously identified this receptor as the lysosome-associated membrane protein type 2a (lamp2a) and showed that levels of lamp2a at the lysosomal membrane directly correlate with the activity of the proteolytic pathway. Here we show that levels of lamp2a at the lysosomal membrane are mainly controlled by changes in its half-life and its distribution between the lysosomal membrane and the matrix. The lysosomal degradation of lamp2a requires the combined action of at least two different proteolytic activities at the lysosomal membrane. Lamp2a is released from the membrane by the action of these proteases, and then the truncated lamp2a is rapidly degraded within the lysosomal matrix. Membrane degradation of lamp2a is a regulated process that is inhibited in the presence of substrates for chaperone-mediated autophagy and under conditions that activate that type of autophagy. Uptake of substrate proteins also results in transport of some intact lamp2a from the lysosomal membrane into the matrix. This fraction of lamp2a can be reinserted back into the lysosomal membrane. The traffic of lamp2a through the lysosomal matrix is not mediated by vesicles, and lamp2a reinsertion requires the lysosomal membrane potential and protein components of the lysosomal membrane. The distribution of lamp2a between the lysosomal membrane and matrix is a dynamic process that contributes to the regulation of lysosomal membrane levels of lamp2a and consequently to the activity of the chaperone-mediated autophagic pathway. 
 Question: Which is the receptor for substrates of Chaperone Mediated Autophagy?
answer:
lamp2a


question:
Context: In previous concepts, you learned about B and T cells, special types of white blood cells that help your body to fight off a specific pathogen. They are necessary when the body is fighting off an infection. But what happens to them after the pathogen has been destroyed? Most B and T cells die after an infection has been brought under control. But some of them survive for many years. They may even survive for a persons lifetime. These long-lasting B and T cells are called memory cells. They allow the immune system to remember the pathogen after the infection is over. If the pathogen invades the body again, the memory cells will start dividing in order to fight the pathogen or disease. These dividing cells will quickly produce a new army of B or T cells to fight the pathogen. They will begin a faster, stronger attack than the first time the pathogen invaded the body. As a result, the immune system will be able to destroy the pathogen before it can cause an infection. Being able to attack the pathogen in this way is called immunity. Immunity can also be caused by vaccination. Vaccination is the process of exposing a person to a pathogen on purpose in order to develop immunity. In vaccination, a modified pathogen is usually injected under the skin by a shot. Only part of the pathogen is injected, or a weak or dead pathogen is used. It sounds dangerous, but the shot prepares your body for fighting the pathogen without causing the actual illness. Vaccination triggers an immune response against the injected antigen. The body prepares "memory" cells for use at a later time, in case the antigen is ever encountered again. Essentially, a vaccine imitates an infection, triggering an immune response, without making a person sick. In many countries, children receive their first vaccination at birth with the Hepatitis B shot, which protects infants from Hepatitis B, a serious liver disease. Before vaccines, many children died from diseases that vaccines now prevent, such as whooping cough, measles, and polio. Those same germs exist today, but because babies are now protected by vaccines, we do not see these diseases nearly as often. Diseases you have probably been vaccinated against include measles, mumps, and chicken pox. How does a vaccine work? See How a Vaccine Works at and The History of Vaccines at . Click image to the left or use the URL below. URL: 
 Question: what is the first vaccination for many children?
answer:

hepatitis b