Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: Imatinib was the first BCR-ABL tyrosine kinase inhibitor to become clinically available. In this study, we retrospectively evaluated the long-term efficacy of low-dose imatinib (final maintenance dose <300mg per day) due to intolerance, in comparison to optimal-dose imatinib (300mg per day) in patients with Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase. The Kaplan-Meier estimates of the median time to complete cytogenetic response, major molecular response, and complete molecular response were longer for 31 patients receiving low-dose imatinib (360, 1360, and 1420days, respectively) than 74 patients receiving optimal-dose imatinib (170, 420, and 720days, respectively). However, the differences in response shrank over time and progression-free survival were comparable between the two groups. These findings suggest that long-term treatment with low-dose imatinib is an acceptable alternative for patients with intolerance to the optimal dose.
[EX A]: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

[EX Q]: Mr. Flip is a 1909 American silent comedy film made by Essanay Studios, directed by Gilbert M. 'Broncho Billy' Anderson and starring Ben Turpin.
[EX A]: What production company was involved in Mr. Flip?

[EX Q]: The Saudades do Brasil (1920), Op. 67, are a suite of twelve dances for piano by Darius Milhaud.
[EX A]:
What type of instrument is Saudades do Brasil designed for?