In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Ex Input:
Paragraph: Rationale: Ex vivo, bronchial epithelial cells from people with asthma are more susceptible to rhinovirus infection caused by deficient induction of the antiviral protein, IFN-b. Exogenous IFN-b restores antiviral activity. Objectives: To compare the efficacy and safety of inhaled IFN-b with placebo administered to people with asthma after onset of cold symptoms to prevent or attenuate asthma symptoms caused by respiratory viruses. Methods: A total of 147 people with asthma on inhaled corticosteroids (British Thoracic Society Steps 2-5), with a history of virus-associated exacerbations, were randomized to 14-day treatment with inhaled IFN-b (n = 72) or placebo (n = 75) within 24 hours of developing cold symptoms and were assessed clinically, with relevant samples collected to assess virus infection and antiviral responses. Measurements and Main Results: A total of 91% of randomized patients developed a defined cold. In this modified intention-to-treat population, asthma symptoms did not get clinically significantly worse (mean change in six-item Asthma Control Questionnaire ,0.5) and IFN-b treatment had no significant effect on this primary endpoint, although it enhanced morning peak expiratory flow recovery (P = 0.033), reduced the need for additional treatment, and boosted innate immunity as assessed by blood and sputum biomarkers. In an exploratory analysis of the subset of more difficult-to-treat, Step 4-5 people with asthma (n = 27 IFN-b; n = 31 placebo), Asthma Control Questionnaire-6 increased significantly on placebo; this was prevented by IFN-b (P = 0.004). Conclusions: Although the trial did not meet its primary endpoint, it suggests that inhaled IFN-b is a potential treatment for virus-induced deteriorations of asthma in difficult-to-treat people with asthma and supports the need for further, adequately powered, trials in this population. Clinical trial registered with www.clinicaltrials.gov (NCT 01126177). 
 Title: The Effect of Inhaled IFN-b on Worsening of Asthma Symptoms Caused by Viral Infections A Randomized Trial

Ex Output:
True


Ex Input:
Paragraph: Rational design of proteins with novel binding specificities and increased affinity is one of the major goals of computational protein design. Epitope-scaffolds are a new class of antigens engineered by transplanting viral epitopes of pre-defined structure to protein scaffolds, or by building protein scaffolds around such epitopes. Epitope-scaffolds are of interest as vaccine components to attempt to elicit neutralizing antibodies targeting the specified epitope. In this study we developed a new computational protocol, MultiGraft Interface, that transplants epitopes but also designs additional scaffold features outside the epitope to enhance antibody-binding specificity and potentially influence the specificity of elicited antibodies. We employed MultiGraft Interface to engineer novel epitope-scaffolds that display the known epitope of HIV-1 neutralizing antibody 2F5 and that also interact with the functionally important CDR H3 antibody loop. MultiGraft Interface generated an epitope-scaffold that bound 2F5 with sub-nanomolar affinity (K D = 400 pM) and that interacted with the antibody CDR H3 loop through computationally designed contacts. Substantial structural modifications were necessary to engineer this antigen, with the 2F5 epitope replacing a helix in the native scaffold and with 15% of the native scaffold sequence being modified in the design stage. This epitope-scaffold represents a successful example of rational protein backbone engineering and protein-protein interface design and could prove useful in the field of HIV vaccine design. MultiGraft Interface can be generally applied to engineer novel binding partners with altered specificity and optimized affinity. § 
 Title: Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5 HHS Public Access

Ex Output:
False


Ex Input:
Paragraph: Background: Early administration of appropriate antimicrobials has been correlated with a better prognosis in bacteremic patients, but a research highlighting a comparison of the adverse impact of inappropriate empirical antibiotic therapy between patient with Gram-positive and Gram-negative bacteremia is insufficient. Methods: In a retrospective cohort study, adults with communityonset monomicrobial bacteremia during the 6-year period were enrolled. Clinical information was retrieved from medical records, using a predetermined case record form. Antimicrobial susceptibility was determined by the disk diffusion method, based on performance standards of the Clinical Laboratory Standard Institute in 2016. A propensity-score-matched analysis was performed to control for the baseline characteristics at bacteremia onset between the Gram-positive and Gram-negative groups. The propensity score was calculated by the independent predictors of 28-day crude mortality recognized by a multivariable logistic regression model. Results: The total 2,053 adults (Gram-positive, 566 patients and Gram-negative, 1,487) presenting with community-onset monomicrobial bacteremia between the six-year period were recruited. Bacteremia severity (a Pitt bacteremia score) at onset and initial manifestation was different between two groups. On the basis of seven independent predictors of 28-day mortality recognized by the multivariate regression.566 of the 1,487 patients in the Gramnegative group were matched to 566 patients in the Gram-positive group with the closest propensity scores. After appropriate propensity-score matching, no significant differences were observed in baseline characteristics and patient outcomes between the two groups, in terms of age, bacteremia severity, major comorbidities, comorbidity severity, and 28-day mortality. 
 Title: P1-BT01 Comparing the effects of inappropriate empirical antibiotic therapy on mortality in adults with community-onset gram- positive and gram-negative bacteremia

Ex Output:

False