In this task, you are given a passage which has a question and the context. You have to generate an answer to the question based on the information present in the context.

Context: To investigate the effects of copper on permeability and P-glycoprotein (P-gp) of Caco-2 cell monolayers.', 'The differentiated Caco-2 cell model was used in this study. Permeability of cell monolayers was reflected by monitoring transepithelial electrical resistance (TEER); distribution of tight junctional protein ZO-1 was measured by immunofluorescent staining; F actin was measured by fluorescence staining; and Activity of P-gp was reflected by changes of transcellular transport and accumulation of Rho-123 in Caco-2 cells.', "Apical treatment with copper (30 - 100 micromol/L, Hanks' buffered salt solution, up to 3 hours) induced a time- and concentration-dependent increase in permeability reflected by progressive decrease of TEER of Caco-2 cell monolayers, accompanied by deorganization of F actin, but without significant effects on tight junctional protein ZO-1; at a dose without any adverse effects on viability and permeability of Caco-2 monolayers, copper treatment (300 micromol/L, complete medium, 24 hours) decreased Papp(BL-->AP) from 7.37 +/- 0.20 x 10(-6) cm/s (controls) to (6.43 +/- 0.27) x 10(-6) cm/s, the increased Papp(AP-->BL) from (1.23 +/- 0.05) x 10(-7) cm/s (controls) to (3.41 +/- 0.08) x 10(-7) cm/s, and enhanced the intracellular Rho-123 from (0.31 +/- 0.01) nmol/filter (controls) to (0.50 +/- 0.03) nmol/filter.\Question: Does [ Copper treatment alter the barrier functions of human intestinal Caco-2 cells ]?
Copper might alter the barrier functions of Caco-2 cells through increasing the permeability and inhibiting P-gp of Caco-2 cells.

Context: Little is known regarding the incidence rate of and factors associated with developing chronic kidney disease after continuous renal replacement therapy (CRRT) in acute kidney injury (AKI) patients. We investigated renal outcomes and the factors associated with incomplete renal recovery in AKI patients who received CRRT.', 'Between January 2011 and November 2013, 408 patients received CRRT in our intensive care unit. Of them, patients who had normal renal function before AKI and were discharged without maintenance renal replacement therapy (RRT) were included in this study. We examined the incidence of incomplete renal recovery with an estimated glomerular filtration rate < 60 mL/min/1.73 m(2) and factors that increased the risk of incomplete renal recovery after AKI.', 'In total, 56 AKI patients were discharged without further RRT and were followed for a mean of 8 months. Incomplete recovery of renal function was observed in 20 of the patients (35.7%). Multivariate analysis revealed old age and long duration of anuria as independent risk factors for incomplete renal recovery (odds ratio [OR], 1.231; 95% confidence interval [CI], 1.041 to 1.457; p = 0.015 and OR, 1.064; 95% CI, 1.001 to 1.131; p = 0.047, respectively). In a receiver operating characteristic curve analysis, a cut-off anuria duration of 24 hours could predict incomplete renal recovery after AKI with a sensitivity of 85.0% and a specificity of 66.7%.\Question: Does duration of anuria predict recovery of renal function after acute kidney injury requiring continuous renal replacement therapy?
The renal outcome of severe AKI requiring CRRT was poor even in patients without further RRT. Long-term monitoring of renal function is needed, especially in severe AKI patients who are old and have a long duration of anuria.

Context: The purpose of this study was to describe patient satisfaction in general practice among the Sámi monolingual population, as compared with the Norwegian population.', "The data was collected in 2002-2004 through a health survey in communities with Sámi and Norwegian population, SAMINOR. The analyses included 15,612 men and women between 36 and 79 years, with a response rate of 60.1%. The questionnaire included questions about patients' satisfaction with primary care and what language they spoke at home.", "The monolingual Sámi population was less satisfied with the primary health care than the Norwegian population, RR 2.4 (95% CI 2.1-2.7) and also less satisfied with the physicians' language skills, RR 5.8 (95% CI 4.8-7.0). Frequent misunderstandings between the physician and the patient based on language difficulty were also reported, RR 3.8 (95% CI 3.3-4.3). In addition, approximately one third of the Sámi did not want to have an interpreter in on the consultation.\Question: Is [ The monolingual Sámi population less satisfied with the primary health care ]?

These results indicated that physicians' knowledge of the Sámi language is important for patient satisfaction in this region.