Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Polycomb gene silencing requires histone methyltransferase activity of Polycomb repressive complex 2 (PRC2), which methylates lysine 27 of histone H3. Information on how PRC2 works is limited by lack of structural data on the catalytic subunit, Enhancer of zeste (E(Z)), and the paucity of E(z) mutant alleles that alter its SET domain. Here we analyze missense alleles of Drosophila E(z), selected for molecular study because of their dominant genetic effects. Four missense alleles identify key E(Z) SET domain residues, and a fifth is located in the adjacent CXC domain. Analysis of mutant PRC2 complexes in vitro, and H3-K27 methylation in vivo, shows that each SET domain mutation disrupts PRC2 histone methyltransferase. Based on known SET domain structures, the mutations likely affect either the lysine-substrate binding pocket, the binding site for the adenosylmethionine methyl donor, or a critical tyrosine predicted to interact with the substrate lysine epsilon-amino group. In contrast, the CXC mutant retains catalytic activity, Lys-27 specificity, and trimethylation capacity. Deletion analysis also reveals a functional requirement for a conserved E(Z) domain N-terminal to CXC and SET. These results identify critical SET domain residues needed for PRC2 enzyme function, and they also emphasize functional inputs from outside the SET domain.
What is the characteristic domain of histone methyltransferases?

Anna Foster (Mandy Moore) is the daughter of the President of the United States, James (Mark Harmon) and First Lady Michelle Foster (Caroline Goodall).When a hassle of Secret Service agents ruins a first date, Anna demands some freedom. Her dad agrees to send only two agents with Anna and Gabrielle La Clare (Beatrice Rosen) to a concert when Anna goes to Prague with her parents. A sexy new look for Anna causes her father to renege. When Anna discovers the concert is filled with agents and that her father has broken his promise, Gabrielle helps Anna elude her protectors. Outside the concert, Anna meets Ben Calder (Matthew Goode), and asks him to drive her to escape the agents. Anna goes to a bar with Ben and proceeds to get drunk. Unbeknownst to Anna, Ben is with the Secret Service, and tells agents Alan Weiss (Jeremy Piven) and Cynthia Morales (Annabella Sciorra) where Anna is. The President orders the three agents to have Ben guard Anna without telling her who he really is, to give her an illusion of freedom with a guarantee of safety. Believing herself free of her guards for the first time in years, Anna jumps into the Vltava River naked, mistaking it for the Danube, and Ben has to fish her out (he stays clothed). Weiss and Morales buy the camera from someone taking pictures of the skinny-dipping Anna. Anna and Ben climb a rooftop to watch an opera being shown in a plaza, where Anna eventually falls asleep with Ben guarding her, and Weiss and Morales watching from another roof.The next morning, Anna calls her parents to avoid getting into further trouble with them. Knowing she is safe, her father is initially indulgent, and Anna is about to return, but his tone changes when he is shown the photos of her nude in the river. The First Lady, however, asks, "What happened to 'let freedom ring?'" (That had been his earlier line when he had decided to let her stay out with Ben.) Anna is outraged at both her dad's sudden imperious tone and finding out that he traced her call. She decides to meet Gabrielle at the Love Parade in Berlin and return to her parents right before the plane trip home. Ben goes with her on the train, where they meet Scotty McGruff (Martin Hancock), a flighty romantic obsessed with Six Million Dollar Man stickers and the interconnectivity of the world, he gives them a stack of stickers and tells them to stick them up in random places, then one day when they are unhappy, they will see one and it will make them smile. Through him, the two learn that they have boarded a Venice-bound train. When they arrive in Venice, Ben calls the other agents to tell them where they are but has to leave the phone dangling when he realizes he can no longer see Anna. He finds her and McGruff getting new clothes, and the three explore Venice - until McGruff steals their wallets. Ben is about to tell the cafe they cannot pay when Anna is recognized and races off to avoid being identified as the First Daughter. Ben follows, and they tell a story of marrying, against the wishes of Anna's parents, to get a gondola ride from a kind-hearted gondolier, Eugenio (Joseph Long). Ben kisses Anna during the ride to hide her from the cafe staff's sight. Since they have no place to stay, Eugenio invites them to his and his mother Maria's (Miriam Margolyes) house. That night, thinking the kiss meant that Ben cares for her, Anna offers herself to him. To dissuade her, Ben is disingenuous and harsh. Anna finally gets in the bed alone, while Ben lies on the floor.The next day, Eugenio drives them to the Austrian border, as Weiss and Morales show up at Maria's looking for the gondolier with whom Anna and Ben were last seen. Maria tells them that Anna and Ben are married, which is reported to Anna's parents. Upset that Ben rejected her, Anna gets a ride on a truck, leaving Ben to
What is Anna's dad occupation?

Linda Westinghouse [Ewa Stromberg], a lawyer with the Istanbul firm of Simpson & Sons, is sent to Anatolia to handle the inheritance of Countess Nadine Carody, recipient of the entire estate of Count Dracula of Hungary. To Linda's surprise, Nadine [Soledad Miranda] is the strange woman who has been haunting her dreams for the past several weeks. Nadine is also a vampire and, after sharing a swim, a glass of wine, and some kisses, Nadine bites Linda's neck and drinks some of her blood. When Linda comes to and goes in search of Nadine, she finds her floating in the swimming pool, apparently dead. The next thing Linda knows, she is being treated at Dr Aldon Seward's clinic, bewildered as to how she got there and amnesic as to her name and address. Dr Seward [Dennis Price] puts a notice in the newspaper, which brings Linda's boyfriend Omar [Andres Monales] looking for her. Linda remembers Omar but still remembers nothing that went on at Countess Carody's beachhouse. Her only memory is of the Countess lying dead in the swimming pool and then being alone at sea. She wonders if it was all a dream.However, Nadine is not dead. She is languishing on a couch, telling her renfield Morpho [Jose Martinez Blanco] how she became a vampire (Dracula saved her from being raped and initiated her into the secret of the vampires) and how she now hates men and is so infatuated with Linda that she must make Linda into a vampire, too. Hearing Nadine calling to her, Linda goes. Nadine drinks a bit more of Linda's blood. Later, Linda consults with Dr Seward who tells her that, if she wishes to extract herself from the spell of the vampire, she must either split the vampire's head with an axe or pierce it with a pole.Meanwhile, one of Dr Seward's patients, Agra [Heidrun Kussin], who has been alternately babbling about the Queen of the Night (Nadine) coming to see her and then abandoning her, now suddenly announces that the Queen is going to come to the sanitarium to meet Seward. Nadine shows up at the sanitarium, angry with Seward for trying to take Linda away from her. Seward admits that he only did it to get Nadine to come to him. He wants to become initiated into the world of the vampires. When Nadine refuses and Seward starts shouting Latin at her, Nadine gets Morpho to kill Seward while she pays a visit with Agra in order to tell her that she's going to leave her again.Meanwhile, Linda goes missing. Omar enlists the help of Linda's shrink, Dr Steiner [Paul Muller], in tracking down Nadine in hopes of finding Linda. Actually, Linda is being held by Memmet [Jesus Franco], the bellboy at her hotel. Turns out Memmet was Agra's husband before she became bewitched by Nadine. Memmet has fallen for Linda and wants to kill her, but Linda kills him first and then escapes. Steiner and Omar go to Nadine's house in Istanbul, but she and Morpho have returned to their beachhouse in Anatolia. Linda goes there, too. She finds Nadine lying in bed, dying. Nadine begs Linda for some blood, but Linda doesn't want to be under Nadine's power and stabs her through the eye. Nadine's body disappears. Morpho kills himself. Omar and Steiner arrive on a boat. Omar tries to convince Linda that it was all a dream, but Linda knows better. [Original Synopsis by bj_kuehl.]

Who begins having dreams about Nadine?