In this task, you are given a sentence. You are expected to recognize the name of gene or protein. Although there might be several correct answers, you need to write one of them.

[EX Q]:  Using the specific pharmacological inhibitors of PI 3 - kinase , Wortmannin and LY294002 , we demonstrate that PI 3 - kinase activity is vital for BCR - induced NF - kappaB DNA - binding activity .
[EX A]: NF - kappaB

[EX Q]:  The differential timing of CD4 and HLA - A2 downmodulation may have implications for HIV pathogenesis and immune evasion .
[EX A]: HLA - A2

[EX Q]:  In contrast , mutations at these two sites do not affect heterodimerization of p65 with p50 or its functional interaction with I kappa B alpha .
[EX A]:
I kappa B