In this task, you are given a passage which has a question and the context. You have to generate an answer to the question based on the information present in the context.

[Q]: Context: We studied the weight of decision-making on clinical assessment of melanocytic lesions judging benign, atypical, and malignant lesions; common mistakes; and total removal rates, comparing dermatologists with nondermatologists.', 'Of 11,246 histopathology specimens, 3,768 had a clinical assessment of melanocytic lesions. Histopathologic diagnosis served as the gold standard.', 'Benign nevi were assessed most accurately (77%). Dermatologists assessed benign nevi better (p < .0001). The accuracy of clinical assessment in atypical nevi and melanoma was lower (23% and 42%, respectively). Seborrheic keratosis was the most common mistaken diagnosis. Complete removal of clinically benign nevi, atypical nevi, and melanoma was 84%, 90%, and 89%. Decision-making impaired clinical assessement of melanocytic lesions by 5% for dermatologists and 9% for nondermatologists.\Question: Does weight of decision-making impair clinical assessment of melanocytic lesions?
[A]: The accuracy of clinical assessment of melanocytic lesions is high for benign nevi, with dermatologists outperforming nondermatologists. Clinicians overestimated malignant potential. Complete removal was more frequent in suspicious lesions. Clinical decision-making impaired assessment by 5 to 9%.


[Q]: Context: Human protectin (CD59) is a regulator of complement activation that inhibits complement-mediated cell lysis, and thus might confer immune resistance to tumor cells. CD59 expression has been described in a variety of human malignancies, including breast cancer. Since a comprehensive investigation of CD59 expression in prostate cancer has not been conducted yet, we aimed to determine the significance of CD59 expression in prostate cancer.', 'Eighty-six primary adenocarcinomas of the prostate were immunostained using a monoclonal CD59 antibody (clone MEM-43) and a standard detection system. The immunoreactivity of the tumor was evaluated as low versus high for statistical analysis. Additionally, CD59 mRNA levels were determined by real-time PCR in matched (tumor/normal) microdissected tissues from 26 cases.', 'Cytoplasmic CD59 immunoreactivity was found in epithelia of prostate cancer, prostatic intraepithelial neoplasia, benign hyperplasia, atrophic, and normal glands. High rates of CD59 expression were noted in 36% of prostate cancer cases and were significantly associated with tumor pT stage (P = 0.043), Gleason grade (P = 0.013) and earlier biochemical (PSA) relapse in Kaplan-Meier analysis (P = 0.0013). On RNA level, we found an upregulation in 19.2% (five cases), although the general rate of CD59 transcript was significantly lower in tumor tissue (P = 0.03).\Question: Does increased CD59 protein expression predict a PSA relapse in patients after radical prostatectomy?
[A]: CD59 protein is strongly expressed in 36% of adenocarcinomas of the prostate and and is associated with disease progression and adverse patient prognosis.


[Q]: Context: To determine the effects of supplemental fiber on plasma p-cresol, stool frequency, and quality of life (QoL) in chronic kidney disease (CKD) patients.', 'In a 12-week single-blind study, participants were provided with control muffins and supplements (5.5\xa0g sucrose/day) for 2\xa0weeks, muffins containing 10\xa0g/day pea hull fiber and control supplements for 4\xa0weeks, and muffins with 10\xa0g/day pea hull fiber and 15\xa0g/day inulin as a supplement for 6\xa0weeks.', 'Individuals with CKD (n\xa0=\xa013; 6 males, 7 females; aged 65\xa0±\xa03\xa0years; estimated glomerular filtration rate <50\xa0mL/minute/1.73(2)) completed the study.', 'Plasma p-cresol was determined by gas chromatography-mass spectrometry, stool frequency by 5-day journals, and QoL by the KDQOL-36™.', 'Plasma p-cresol decreased from 7.25\xa0±\xa01.74\xa0mg/L during week 1 to 5.82\xa0±\xa01.72\xa0mg/L during week 12 (P\xa0<\xa0.05), and in participants with high compliance (>70% inulin intake), from 6.71\xa0±\xa01.98\xa0mg/L to 4.22\xa0±\xa01.16\xa0mg/L (P\xa0<\xa0.05). Total fiber intake increased from 16.6\xa0±\xa01.7\xa0g/day during control to 26.5\xa0±\xa02.4\xa0g/day (P\xa0<\xa0.0001) with the added pea hull and to 34.5\xa0±\xa02.2\xa0g/day with pea hull and inulin (P\xa0<\xa0.0001). Stool frequency increased from 1.4\xa0±\xa00.2 stools/day during control to 1.9\xa0±\xa00.3 stools/day during both fiber periods (P\xa0<\xa0.05). No change in overall QoL was observed.\Question: Does fiber supplementation lower plasma p-cresol in chronic kidney disease patients?
[A]:
Supplementing the diet of CKD patients with fiber may be a dietary therapy to reduce p-cresol and improve stool frequency.