instruction:
In this task, you are given a sentence. You are expected to recognize the name of gene or protein. Although there might be several correct answers, you need to write one of them.
question:
 Further , we find that HEB driven by the endogenous E2A promoter can functionally replace E2A in supporting B - cell commitment and differentiation toward completion .
answer:
endogenous E2A promoter


question:
 Nevertheless , inhibitors of these pathways clearly reduced the TNF - alpha - induced cell growth , indicating that TNF - alpha - proliferative cells produced a growth factor that induced proliferation upon stimulation of the above pathways .
answer:
TNF - alpha


question:
 To study the mechanism by which protein tyrosine phosphatases ( PTPs ) regulate CD3 - induced tyrosine phosphorylation , we investigated the distribution of PTPs in subdomains of plasma membrane .
answer:

protein tyrosine phosphatases