Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

The translocation (9;22) gives rise to the p190(Bcr-Abl) and p210(Bcr-Abl) tyrosine kinase proteins, considered sufficient for leukemic transformation. Philadelphia-positive (Ph(+)) acute leukemia patients failing to respond to initial induction therapy have a poor prognosis with few effective treatment options. Imatinib is an orally administered, potent inhibitor of the Bcr-Abl tyrosine kinase. We conducted a clinical trial in 56 patients with relapsed or refractory Ph(+) acute lymphoblastic leukemia (ALL; 48 patients) or chronic myelogenous leukemia in lymphoid blast crisis (LyBC; 8 patients). Imatinib was given once daily at 400 mg or 600 mg. Imatinib induced complete hematologic responses (CHRs) and complete marrow responses (marrow-CRs) in 29% of ALL patients (CHR, 19%; marrow-CR, 10%), which were sustained for at least 4 weeks in 6% of patients. Median estimated time to progression and overall survival for ALL patients were 2.2 and 4.9 months, respectively. CHRs were reported for 3 (38%) of the patients with LyBC (one sustained CHR). Grade 3 or 4 treatment-related nonhematologic toxicity was reported for 9% of patients; none of the patients discontinued therapy because of nonhematologic adverse reactions. Grade 4 neutropenia and thrombocytopenia occurred in 54% and 27% of patients, respectively. Imatinib therapy resulted in a clinically relevant hematologic response rate in relapsed or refractory Ph(+) acute lymphoid leukemia patients, but development of resistance and subsequent disease progression were rapid. Further studies are warranted to test the effects of imatinib in combination with other agents and to define the mechanisms of resistance to imatinib.
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

Menpehtyre Ramesses I (traditional English: Ramesses or Ramses) was the founding pharaoh of ancient Egypt's 19th dynasty.
What is the position of Ramesses I?

Want to save money when travelling by train? Here are some ways. Day Returns This ticket can save you up to 45% on the standard fare . You have to travel after the rush hour period Mon.-Fri., but can travel at any time on Sat. or Sun. Big city Saves These are special low-priced tickets on certain trains. Yon have to book in advance----- at the latest by 16:00 the day before you travel. It's first come, first served. Weekend Returns Weekend Returns are available for most journeys over 60 miles. Go on Fri. Sat. or Sun, and return the same weekend on Sat. or Sun, and save up to 35% the standard fare. Monthly Returns There are available for most journeys over 65 miles. Go any day and return within a month. Monthly returns save you up to 25% on the standard fare. Family Returns For PS20 this railcard allows you to take a second adult and up to 4 children for only PS3 each when you buy single or return tickets. You can travel as often as you like until the card becomes out of date. (200 words.3min.)

Which is the best ticket to buy if you live in London and want to go to a small town 80miles away for four days?