Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: Michael Jackson is one of the world's best singers. Michael Jackson was born in the middle west of the city of Gary, Indiana, in 1958. He began singing with his four brothers. They called the group "The Jackson Five". The group became very popular after appearing on a television program. They started singing in 1965, and became popular soon. In 1970 the group made their first record with the name of "I Want You Back". It was very popular. One of their hit records was "Never Say Goodbye". Michael was good at dancing as well as singing, such as his dance moves and moon walking. He was asked to act in a film in 1978 for the first time, and in the same year he made a record on his own, which sold eight million _ all over the world. Michael nearly didn't go out because he was too famous. Once his fans went off in a faint when they saw him at the concert. No one can do it by now. He lived in a large house and kept lots of animals. He never ate meat. He often raised money for Charity. This made him win the Guinness World Records in 2006. He died on June 25th, 2009, but he would live in our heart forever.
[EX A]: What's the name of their first record?

[EX Q]: The 49ers meet the Ravens for the first time since Super Bowl XLVII, in which the Ravens won 34-31. In the second quarter, Colin Kaepernick threw a 76-yard pass to ex-Raven Torrey Smith to lead San Francisco 13-3. In the fourth quarter, Kaepernick threw another touchdown, this time to Quinton Patton, for 11-yard pass to lead the 49ers 25-13. This was Patton's first NFL touchdown. With the win, the 49ers have avenged their Super Bowl loss and broke their 4-game losing streak, and they go to 2-4.
[EX A]: Who threw the longest touchdown pass of the game?

[EX Q]: Alzheimer's disease (AD) is the most common cause of dementia in humans. A pathological hallmark in the brain of an AD patient is extracellular amyloid plaques formed by accumulated beta-amyloid protein (Abeta), a metabolic product of amyloid precursor protein (APP). Studies have revealed a strong genetic linkage in the early-onset familial form (<60 years old) of AD. For example, some mutant APPs are transmitted dominantly and are segregated with inheritance of early onset AD. These mutants facilitate Abeta production. The "Swedish" mutations (APP(SW)) and the "London" mutation (APP(LON)) are examples of these mutants. Selective silencing of these mutant alleles holds therapeutic promise for AD. Here we show that the expression of the mutant APPs was selectively inhibited by RNA interference. The best selectivity was obtained when the mismatches were centrally placed in the antisense strand of small interfering RNAs. Introducing an additional mismatch in the antisense strand may improve the selectivity. The addition of a G at 5' end of the antisense strand may enhance the efficacy of gene silencing by RNA interference. Our results illustrate the guiding principles for selection of targeted sequences to achieve allele-specific silencing. The sequences that are effective to silence APP(SW) and APP(LON) as identified in this study may be useful in both in vivo and in vitro studies to investigate the pathophysiological role of APP(SW) and APP(LON) in AD development.
[EX A]:
Which disease the London mutation involved in?