Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
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Question: In the second patient, acute renal failure necessitated hemodialysis.

Answer: non-adverse drug event


Question: Sweet's syndrome associated with sargramostim (granulocyte-macrophage colony stimulating factor) treatment.

Answer: adverse drug event


Question: Little inflammatory change was noted in either the epithelial or stromal layers of the failed graft.

Answer:
non-adverse drug event