TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Judge Dan Haywood (Spencer Tracy) arrives in Nuremberg in 1948 to preside over the trial of four Nazi judges, each charged with having abused the court system to help cleanse Germany of the politically and socially undesirable, allegedly guilty of war crimes. The opening statement of the prosecuting attorney (Richard Widmark) is a vicious one, depicting the defendants as having been willing, evil, accomplices in Nazi atrocities, but Judge Haywood wonders if it is really that simple.Confounded at how one defendant, a renowned German champion of justice named Ernst Janning (Burt Lancaster), appears to have played the greatest role in molding Germany's Ministry of Justice into a destructive instrument of Nazism, Judge Haywood resolves to gain some perspective on the period in which the German legal system strayed from a course of entirely objective justice.Probing for the truth proves difficult, though, as nobody who lived in Germany during Nazism seems to admit to having much inside knowledge. He befriends Mrs. Bertholt (Marlene Dietrich), the widow of an executed Nazi army officer, but she offers few insights, more consumed by her personal experiences than the broader matters of Nazism. Mrs. Bertholt is focusing on being a catalyst for the cultural rebirth of Nuremberg, keen on remolding the image of a city that had become notorious as the site of the Nazi raliies. An attempt to discuss the period with his housekeepers, Mr. and Mrs. Halbestadt, who had lived near the Dachau concentration camp, proves equally fruitless for Judge Haywood, as they cannot help but focus on the loss of their child in the bombing and the fact that they nearly starved from poverty. Whether anyone knew anything mattered little, for Germans were looking forward, not backward, still grappling with, and recovering from, the hardships and losses that the war brought to them and their families.Only in the courtroom will Judge Haywood have the opportunity to gain insights into the realities of the period. First hand evidence of a) all German judges having sworn to a Nazi oath of allegiance, b) human sterilization orders signed by the defendants and carried out, and c) the execution of a Jew merely for having relations with a non-Jew, painted an evil picture of the ways in which the law had been applied by the defendants during Nazism. Still, Judge Haywood cannot fully come to grips with why these judges had been willing to enforce the law in such a horrific manner. Not, at least, until the defendant Ernst Janning feels compelled to make a statement, against the advice of his counsel (Maximilian Schell).In his statement made under oath, Janning speaks of how economically-stricken Germany had become a nation of fearful, desperate people, and how only such a people could submit to Nazism. Hitler's promises, Janning explained, in which he openly vowed the elimination of those accountable for Germany's hardships were, at first, soothing and reassuring to them. Janning then noted that, even once the complicit realized the unconscionability and inhumanity of Hitler's approach, they stayed at their posts to help things from getting even worse, but, predictably, failed to derail the atrocities of the times. He explained that national allegiance had motivated most of them to the point that they sacrificed their own personal senses of morality. In a deeply personal, yet self-damning, statement, he conceded that most of them should have known better, and that those that had gone along had betrayed Germany.At long last, the issue at the heart of the case becomes clear to Judge Haywood - the choice that the defendants had to make was between allegiance to their country and allegiance to their own senses of right and wrong. Understanding the times and context in which the actions of the defendants took place, Judge Haywood is ready to pass judgment on the defendants. He sentences each to life imprisonment, noting that their actions were illegal under both International law and German law, and further notes that they were men of sufficient intellect, prominence and credibility in Germany that their refusal to help transform the German court system into an institution that, systematically, denied justice to enemies of the Third Reich might have made a difference.As noted in

SOLUTION: how many defendants are found guilty and sentenced to life in prison?

PROBLEM: Claude Rains and James Stewart in Mr. Smith Goes to Washington Play media Trailer James Stewart and Jean Arthur in a taxicab The governor of an unnamed western state, Hubert "Happy" Hopper (Guy Kibbee), has to pick a replacement for recently deceased U.S. Senator Sam Foley. His corrupt political boss, Jim Taylor (Edward Arnold), pressures Hopper to choose his handpicked stooge, while popular committees want a reformer, Henry Hill. The governor's children want him to select Jefferson Smith (James Stewart), the head of the Boy Rangers. Unable to make up his mind between Taylor's stooge and the reformer, Hopper decides to flip a coin. When it lands on edge and next to a newspaper story on one of Smith's accomplishments he chooses Smith, calculating that his wholesome image will please the people while his naivete will make him easy to manipulate. Junior Senator Smith is taken under the wing of the publicly esteemed, but secretly crooked, Senator Joseph Paine (Claude Rains), who was Smith's late father's friend. Smith develops an immediate attraction to the senator's daughter, Susan (Astrid Allwyn). At Senator Paine's home, Smith has a conversation with Susan, fidgeting and bumbling, entranced by the young socialite. Smith's naive and honest nature allows the unforgiving Washington press to take advantage of him, quickly tarnishing Smith's reputation with ridiculous front page pictures and headlines branding him a bumpkin. To keep Smith busy, Paine suggests he propose a bill. With the help of his secretary, Clarissa Saunders (Jean Arthur), who was the aide to Smith's predecessor and had been around Washington and politics for years, Smith comes up with a bill to authorize a federal government loan to buy some land in his home state for a national boys' camp, to be paid back by youngsters across America. Donations pour in immediately. However, the proposed campsite is already part of a dam-building graft scheme included in an appropriations bill framed by the Taylor political machine and supported by Senator Paine. Unwilling to crucify the worshipful Smith so that their graft plan will go through, Paine tells Taylor he wants out, but Taylor reminds him that Paine is in power primarily through Taylor's influence. Through Paine, the machine in his state accuses Smith of trying to profit from his bill by producing fraudulent evidence that Smith already owns the land in question. Smith is too shocked by Paine's betrayal to defend himself, and runs away. Saunders, who looked down on Smith at first, but has come to believe in him, talks him into launching a filibuster to postpone the appropriations bill and prove his innocence on the Senate floor just before the vote to expel him. In his last chance to prove his innocence, he talks non-stop for about 24 hours, reaffirming the American ideals of freedom and disclosing the true motives of the dam scheme. Yet none of the Senators are convinced. The constituents try to rally around him, but the entrenched opposition is too powerful, and all attempts are crushed. Owing to the influence of Taylor's machine, newspapers and radio stations in Smith's home state, on Taylor's orders, refuse to report what Smith has to say and even distort the facts against the senator. An effort by the Boy Rangers to spread the news in support of Smith results in vicious attacks on the children by Taylor's minions. Although all hope seems lost, the senators begin to pay attention as Smith approaches utter exhaustion. Paine has one last card up his sleeve: he brings in bins of letters and telegrams from Smith's home state, purportedly from average people demanding his expulsion. Nearly broken by the news, Smith finds a small ray of hope in a friendly smile from the President of the Senate (Harry Carey). Smith vows to press on until people believe him, but immediately collapses in a faint. Overcome with guilt, Paine leaves the Senate chamber and attempts to commit suicide, but is stopped by other senators. When he is stopped, he bursts back into the Senate chamber, loudly confessing to the whole scheme;

SOLUTION: Who plays Hopper?

PROBLEM: Brown and beige adipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energy as heat. These cells likely possess alternative UCP1-independent thermogenic mechanisms. Here, we identify a secreted enzyme, peptidase M20 domain containing 1 (PM20D1), that is enriched in UCP1(+) versus UCP1(-) adipocytes. Wedemonstrate that PM20D1 is a bidirectional enzyme invitro, catalyzing both the condensation of fatty acids and amino acids to generate N-acyl amino acids and also the reverse hydrolytic reaction. N-acyl amino acids directly bind mitochondria and function as endogenous uncouplers of UCP1-independent respiration. Mice with increased circulating PM20D1 have augmented respiration and increased N-acyl amino acids in blood. Lastly, administration of N-acyl amino acids to mice improves glucose homeostasis and increases energy expenditure. These data identify an enzymatic node and a family of metabolites that regulate energy homeostasis. This pathway might be useful for treating obesity and associated disorders.

SOLUTION:
Where is the enzyme PM20D1 localized?