TASK DEFINITION: Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.
PROBLEM: The test examines more than 2 million spots in a person’s genetic code, seeking variants that individually nudge a person’s obesity risk up by a tiny amount. The researchers drew on previously published data about those variants to create a risk score. A high score didn’t guarantee obesity, nor a low score rule it out. But middle-aged people with scores in the top 10 percent were 25 times as likely to be severely obese as those in the bottom 10 percent, scientists reported in a paper released Thursday by the journal Cell. Those two groups were separated by an average weight difference of about 29 pounds (13 kilograms), researchers said. Analysis showed the genetic propensity to obesity began having an effect on weight around age 3. Up to about age 8, “you might be able to make a difference in the kids who are born susceptible to obesity,” said one author of the study, Dr. Sekar Kathiresan of Massachusetts General Hospital in Boston and the Broad Institute of MIT and Harvard. But it will take further research to see whether intervening would work, Kathiresan said. The results for middle age came from a study of about 288,000 people. Overall, the risk-score research included data from more than 300,000 people at various ages. Severe obesity was defined as a body mass index of 40 or more. Results show genetic inheritance “plays a large role in how heavy one gets,” Kathiresan said. The risk score probably takes about half of a person’s genetic propensity into account, he said, and it shows similar accuracy in predicting ordinary obesity, defined as a BMI of 30 or more. Even if one inherits a propensity for obesity, he said, “you still have control over your fate. You’re not fated to be obese, but it’s very clear those individuals who’ve inherited susceptibility have to work that much harder to keep the weight off.” Among study participants with the highest scores, he noted, 17 percent were of normal weight. Other analyses show that people who remain lean despite an inherited propensity for obesity tend to eat better and have more physical activity than others with a high score who got fat. “So you can do something about it,” he said. Ruth Loos, a professor of environmental medicine and public health who did not participate in the study, said the risk score explains more of people’s genetic tendency than previous studies did. But she doubted it would be useful in a doctor’s office. It is “never going to be a good predictor,” said Loos, of the Icahn School of Medicine at Mt. Sinai in New York. She noted that in one test of the score’s predictive power, only 58 of the 371 subjects scoring in the top 10 percent ended up severely obese. And many other severely obese people didn’t score in the top 10 percent, she said. Simply asking about family history of obesity would probably work better, she said. The large role of lifestyle in obesity means a purely gene-based predictor will never be perfect, she said. Kathiresan, a cardiologist, said the risk score is best seen as a risk indicator, like high cholesterol. Most people with high cholesterol don’t get heart attacks, he said, but they do run a higher risk than others. Jason Boardman of the University of Colorado Boulder said genetic variants might affect body size indirectly, through an impact on lifestyles or other social and behavioral traits. Other research suggests the effect of genes on size depends on what kind of social and physical environment a person lives in, including such factors as access to unhealthy foods, he said in an email. ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.

SOLUTION: Study: Genetic test predicts middle-aged obesity risk.

PROBLEM: Most cases are reported in the northern and eastern panhandles probably because of their proximity to the high-incidence states of Maryland, Pennsylvania, and Virginia, the Department of Health and Human Resources said. In an advisory Monday to health care providers, Health Commissioner Dr. Rahul Gupta wrote that the increase could be from increased reporting or from more ticks infected with the bacteria. Most cases appear between May and September, but ticks have become more active in winter months, he said. According to the department, 580 cases have been reported so far this year, up from 97 statewide in 2012. “Based on the change, West Virginia is considered a high incidence Lyme disease state,” Gupta wrote. Patients treated early with antibiotics usually recover quickly. He recommended a two-step blood test to confirm evidence of antibodies against the Lyme disease bacteria. Symptoms often include a circular rash around a tick bite and fever, headaches and fatigue, according to the U.S. Centers for Disease Control. If left untreated, the infection can spread to joints, the heart and the nervous system. The CDC says there were more than 36,000 probable cases in the U.S. last year, with 26,203 confirmed.

SOLUTION: West Virginia reports increasing Lyme disease cases.

PROBLEM: The Daily Mining Gazette of Houghton reports the Environmental Protection Agency is seeking public comment on the proposal by the Keweenaw Bay Indian Community’s application. If approved, the tribe would be allowed to develop and maintain its own water-quality standards for surface waters on its reservation. Concerns about water quality potentially affecting the Upper Peninsula reservation are linked to cattle farming; commercial logging, mining; runoff from road salt; illegal dumping; industrial discharge; septic systems; and lawn chemicals. The newspaper says the public comment period is open until May 23. Officials announced earlier this year that the EPA awarded a $195,000 grant to the tribe to modernize its environmental data reporting system. ___ Information from: The Daily Mining Gazette, http://www.mininggazette.com

SOLUTION:
Native American tribe seeks to set water quality standards.