Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: You must have been troubled by when to say "I love you" because it is one of the greatest puzzles in our life. What if you say it first and your partner doesn't love you back? Or if they do say it but you don't feel they mean it? Being the first to declare your love can be never racking and risky and can leave you feeling as vulnerable as a turtle with no shell. But is the person who says it first really in a position of weakness? Doesn't it pay to hold back, play it cool and wait until the other half has shown their hand faster? "A really good relationship should be about being fair and being equal," says psychologist Sidney Crown. "But love is seldom equal." "All relationships go through power struggles but," he says, "if a love imbalance continues for years, the rot will set in." That feeling of "I've always loved you more" may be subverted (,) for a time, but it never goes away completely and it often emerges in squabbling . In love, at least, the silent, withholding type is not always the most powerful. "The strongest one in a relationship is often the person who feels confident enough to talk about their feelings," says educational psychologist Ingrid Collins. Psychosexual therapist Paula Hall agrees. "The one with the upper hand is often the person who takes the initiative." In fact, the person who says "I love you" first may also be the one who says "I'm bored with you' first." Hall believes that much depends on how "I love you" is said and the motivation of the person saying it. Is it said when they're drunk? Is it said before their partner flies off on holiday, and what it really means is "Please don' t be unfaithful to me" ? By saying "I love you", they are really saying "Do you love me?" If so, wouldn't it just be more honest to say that. Collins agrees that intention is everything. "It's not what is said, but how it's said. What it comes down to is the sincerity of the speaker."

Answer: What is the most important for you to consider when somebody say "I love you" to you?


Question: A significant role for IFN in the pathogenesis of systemic lupus erythematosus is well supported, and clinical trials of anti-IFN monoclonal antibodies are in progress in this disease. In other autoimmune diseases characterized by substantial inflammation and tissue destruction, the role of type I interferons is less clear. Gene expression analysis of peripheral blood cells from patients with rheumatoid arthritis and multiple sclerosis demonstrate an interferon signature similar to but less intense than that seen in patients with lupus. In both of those diseases, presence of the interferon signature has been associated with more significant clinical manifestations. At the same time, evidence supports an anti-inflammatory and beneficial role of IFN locally in the joints of patients with rheumatoid arthritis and in murine arthritis models, and many patients with multiple sclerosis show a clinical response to recombinant IFN. As can also be proposed for type I diabetes mellitus, type I interferon appears to contribute to the development of autoimmunity and disease progression in multiple autoimmune diseases, while maintaining some capacity to control established disease - particularly at local sites of inflammation. Recent studies in both rheumatoid arthritis and multiple sclerosis suggest that quantification of type I interferon activity or target gene expression might be informative in predicting responses to distinct classes of therapeutic agents.

Answer: Which is the most common gene signature in Rheumatoid Arthritis patients?


Question: Nurith Aviv is Professor at La Femis (Paris), and was, in 1975, the first woman in France to be officially recognized as a Director of Photography by the CNC (Centre National de la cinematographie).

Answer:
What is Nurith Aviv's place of employment?