instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
When you make a mistake, big or small, cherish it like it's the most precious thing in the world, because in some ways, it is. Most of us feel bad when we make mistakes, beat ourselves up about it, feel like failures, get mad at ourselves. And that's only natural. Most of us have been taught from a young age that mistakes are bad, and we should try to avoid mistakes. We've been scolded when we make mistakes--at home, school and work. Maybe not always, but probably enough times to make feeling bad about mistakes an unconscious reaction. Yet without mistakes, we could not learn or grow. If you think about it that way, mistakes should be cherished and celebrated for being one of the most amazing things in the world. They make learning possible; they make growth and improvement possible. By trial and error--trying things, making mistakes, and learning from those mistakes--we have figured out how to make electric light, to paint the ceiling of the Sistine Chapel, to fly. Mistakes make walking possible for the smallest _ , make speech possible, and make works of genius possible. Think about how we learn:We don't just consume information about something and instantly know it or know how to do it. You don't just read about painting,or writing,or computer programming,or baking, or playing the piano, and know how to do them right away. Instead, you get information about something, from reading or from another person or from observing usually...then you construct a model in your mind...then you test it out by trying it in the real world...then you make mistakes...then you revise the model based on the results of your real world experimentation...and repeat, making mistakes, learning from those mistakes, until you've pretty much learned how to do something. That's how we learn as babies and toddlers, and how we learn as adults. Mistakes are how we learn to do something new--because if you succeed at something, it's probably something you already knew how to do. You haven't really grown much from that success--at most it's the last step on your journey, not the whole journey. Most of the journey is made up of mistakes, if it's a good journey. So if you value learning,if you value growing and improving,then you should value mistakes. They are amazing things that make a world of brilliance possible.
answer:
What is the best title of this passage?


question:
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. Despite significant progresses in the last decades, the origin of this cancer remains unclear and no efficient therapy exists. PDAC does not arise de novo: three remarkable different types of pancreatic lesions can evolve towards pancreatic cancer. These precursor lesions include: Pancreatic intraepithelial neoplasia (PanIN) that are microscopic lesions of the pancreas, Intraductal Papillary Mucinous Neoplasms (IPMN) and Mucinous Cystic Neoplasms (MCN) that are both macroscopic lesions. However, the cellular origin of these lesions is still a matter of debate. Classically, neoplasm initiation or progression is driven by several genetic and epigenetic alterations. The aim of this review is to assemble the current information on genetic mutations and epigenetic disorders that affect genes during pancreatic carcinogenesis. We will further discuss the interest of the genetic and epigenetic alterations for the diagnosis and prognosis of PDAC. Large genetic alterations (chromosomal deletion/amplification) and single point mutations are well described for carcinogenesis inducers. Mutations classically occur within key regions of the genome. Consequences are various and include activation of mitogenic pathways or silencing of apoptotic processes. Alterations of K-RAS, P16 and DPC4 genes are frequently observed in PDAC samples and have been described to arise gradually during carcinogenesis. DNA methylation is an epigenetic process involved in imprinting and X chromosome inactivation. Alteration of DNA methylation patterns leads to deregulation of gene expression, in the absence of mutation. Both genetic and epigenetic events influence genes and non-coding RNA expression, with dramatic effects on proliferation, survival and invasion. Besides improvement in our fundamental understanding of PDAC development, highlighting the molecular alterations that occur in pancreatic carcinogenesis could provide new clinical tools for early diagnosis of PDAC and the molecular basis for the development of new effective therapies.
answer:
Which is the molecular mechanism underlying K-ras alterations in carcinomas?


question:
Jefte Betancor Sanchez (born 6 July 1993) is a Spanish footballer who plays for UD Las Palmas Atletico as a forward.
answer:

What is the date of birth for Jefté Betancor?