Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

Q: Neutrophils provide an early, rapid, and nonspecific defense against invading pathogens.

A: What provides an early, rapid, and nonspecific defense against invading pathogens?
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Q: Gastro-esophageal sphincter sphincter is located at the stomach end of the esophagus and opens to allow the bolus to enter the stomach.

A: Which sphincter is located at the stomach end of the esophagus and opens to allow the bolus to enter the stomach?
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Q: Insulin production is the main problem in both types of diabetes.

A:
What is the main problem in both types of diabetes?
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