In this task, you are given a question and a context passage. You have to answer the question based on the given passage.

What needs to decrease before pituitary growth hormone can increase in the blood?, Context: In addition to the negative consequences of sleep deprivation, sleep and the intertwined circadian system have been shown to have strong regulatory effects on immunological functions affecting both the innate and the adaptive immunity. First, during the early slow-wave-sleep stage, a sudden drop in blood levels of cortisol, epinephrine, and norepinephrine induce increased blood levels of the hormones leptin, pituitary growth hormone, and prolactin. These signals induce a pro-inflammatory state through the production of the pro-inflammatory cytokines interleukin-1, interleukin-12, TNF-alpha and IFN-gamma. These cytokines then stimulate immune functions such as immune cells activation, proliferation, and differentiation. It is during this time that undifferentiated, or less differentiated, like naïve and central memory T cells, peak (i.e. during a time of a slowly evolving adaptive immune response). In addition to these effects, the milieu of hormones produced at this time (leptin, pituitary growth hormone, and prolactin) support the interactions between APCs and T-cells, a shift of the Th1/Th2 cytokine balance towards one that supports Th1, an increase in overall Th cell proliferation, and naïve T cell migration to lymph nodes. This milieu is also thought to support the formation of long-lasting immune memory through the initiation of Th1 immune responses.
cortisol, epinephrine, and norepinephrine

What is Rayleigh scattering?, Context: In nature, the red color of blood comes from hemoglobin, the iron-containing protein found in the red blood cells of all vertebrates. The red color of the Grand Canyon and other geological features is caused by hematite or red ochre, both forms of iron oxide. It also causes the red color of the planet Mars. The red sky at sunset and sunrise is caused by an optical effect known as Rayleigh scattering, which, when the sun is low or below the horizon, increases the red-wavelength light that reaches the eye. The color of autumn leaves is caused by pigments called anthocyanins, which are produced towards the end of summer, when the green chlorophyll is no longer produced. One to two percent of the human population has red hair; the color is produced by high levels of the reddish pigment pheomelanin (which also accounts for the red color of the lips) and relatively low levels of the dark pigment eumelanin.
optical effect

What did French academic circles refer to the Ottoman Empire as?, Context: Near East (French: Proche-Orient) is a geographical term that roughly encompasses Western Asia. Despite having varying definitions within different academic circles, the term was originally applied to the maximum extent of the Ottoman Empire. The term has fallen into disuse in English, and has been replaced by the term Middle East.

Proche-Orient