instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
The 1980 film Magnificent 72 and the 2011 film 72 Heroes focus on the uprising. Events of the uprising open the 2011 film 1911.
answer:
Which film cam out first, in 1980 Magnificent 72 or 2011 72 Heroes?


question:
In cancer research, background models for mutation rates have been extensively calibrated in coding regions, leading to the identification of many driver genes, recurrently mutated more than expected. Noncoding regions are also associated with disease; however, background models for them have not been investigated in as much detail. This is partially due to limited noncoding functional annotation. Also, great mutation heterogeneity and potential correlations between neighboring sites give rise to substantial overdispersion in mutation count, resulting in problematic background rate estimation. Here, we address these issues with a new computational framework called LARVA. It integrates variants with a comprehensive set of noncoding functional elements, modeling the mutation counts of the elements with a -binomial distribution to handle overdispersion. LARVA, moreover, uses regional genomic features such as replication timing to better estimate local mutation rates and mutational hotspots. We demonstrate LARVA's effectiveness on 760 whole-genome tumor sequences, showing that it identifies well-known noncoding drivers, such as mutations in the TERT promoter. Furthermore, LARVA highlights several novel highly mutated regulatory sites that could potentially be noncoding drivers. We make LARVA available as a software tool and release our highly mutated annotations as an online resource (larva.gersteinlab.org).
answer:
Which tool is used for the identification of recurrent variants in noncoding regions?


question:
The Black Camel (1929) is the fourth of the Charlie Chan novels by Earl Derr Biggers.
answer:

To which series does The Black Camel belong?