Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Example Input: Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.
Example Output: adverse drug event

Example Input: Physicians should be aware of the potentially lethal side effects of dapsone.
Example Output: adverse drug event

Example Input: Continuing the treatment with 13-cis-retinoic acid without systemic steroid eventually cleared the systemic manifestations and skin lesions.
Example Output:
non-adverse drug event