In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Ex Input:
Question: 78-year-old man with poorly controlled rheumatoid arthritis (RA). A history of 2 admissions for heart failure and atrial fibrillation in the last 6 months. In current treatment with infliximab, prednisone, furosemide, enalapril, carvedilol and acenocoumarol. Enter again for biventricular heart failure clinic. The ECG showed atrial fibrillation at 102 bpm and advanced left bundle branch block. An echocardiogram shows biatrial dilation, thickening of the left ventricular wall with ejection fraction of 45% and restrictive pattern. The analytical highlights: Hb 10 gr / dL, creatinine 2.1 mg / dL (FG 20 mL / min), CRP 124 mg / L, rheumatoid factor 240 U / L, BNP 980 ng / L, proteinuria 4.8 g / 24h. What is the most likely diagnosis? 
 Options:  <1> Cardio-renal syndrome type 2. <2> Amyloidosis AA. <3> Myocarditis of giant cells. <4> Toxicity due to infliximab. <5> Membranous glomerulonephritis associated with RA.

Ex Output:
2


Ex Input:
Question: The hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C generates the following second messengers: 
 Options:  <1> Inositol 1,4,5-trisphosphate and triacylglycerol. <2> Inositol 1,4, 5-trisphosphate and glycerol. <3> Inositol 1,4, 5-trisphosphate and diacylglycerol. <4> Inositol 4,5-bisphosphate and diacylglycerol. <5> Inositol 4,5-bisphosphate and glycerol.

Ex Output:
3


Ex Input:
Question: Pyruvate carboxylase is allosterically activated by one of the following compounds, what is it? 
 Options:  <1> Pyruvate. <2> Acetyl-CoA. <3> Malate. <4> Oxalacetate. <5> NAD +.

Ex Output:

2