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Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.
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Paragraph: At issue are genes called BRCA1 and BRCA2. When they’re mutated, the body can’t repair damaged DNA as well, greatly increasing the chances of breast, ovarian and certain other cancers. Gene testing allows affected women to consider steps to lower their risk, such as when actress Angelina Jolie underwent a preventive mastectomy several years ago. Most cancer isn’t caused by BRCA mutations — they account for 5% to 10% of breast cancers and 15% of ovarian cancers — so the gene tests aren’t for everyone. But mutations cluster in families, and the U.S. Preventive Services Task Force has long recommended that doctors screen women who have relatives with BRCA-related cancers and refer those who might benefit from gene testing to a genetic counselor to help them decide. Tuesday, the task force expanded that advice, telling primary care doctors they should also assess women’s risk if: —they previously were treated for breast or other BRCA-related cancers including ovarian, fallopian tube or peritoneal cancers, and now are considered cancer-free. —their ancestry is prone to BRCA mutations, such as Ashkenazi Jewish women. Why screen breast cancer survivors? After all, they already know there’s a risk of recurrence. Take, for example, someone who had a tumor removed in one breast in their 40s a decade ago, when genetic testing wasn’t as common. Even this many years later, a BRCA test still could reveal if they’re at risk for ovarian cancer — or at higher than usual risk for another tumor in their remaining breast tissue, explained task force member Dr. Carol Mangione of the University of California, Los Angeles. And it could alert their daughters or other relatives to a potential shared risk. “It’s important to test those people now,” Mangione said. “We need to get the word out to primary care doctors to do this assessment and to make the referrals.” Private insurers follow task force recommendations on what preventive care to cover, some at no out-of-pocket cost under rules from former President Barack Obama’s health care law. The recommendations were published in the Journal of the American Medical Association. Cancer groups have similar recommendations for BRCA testing, and increasingly urge that the newly diagnosed be tested, too, because the inherited risk can impact choices about surgery and other treatment. Identifying BRCA mutation carriers “can be lifesaving, and should be a part of routine medical care,” Drs. Susan Domchek of the University of Pennsylvania and Mark Robson of Memorial Sloan Kettering Cancer Center, who weren’t involved with the new guidelines, wrote in an editorial accompanying them. But too few high-risk women ever learn if they harbor BRCA mutations, they wrote. For example, cancer groups have long recommended that all ovarian cancer patients be tested, but several studies have found testing is done in less than a third. Don’t skip the genetic counseling, said the task force’s Mangione. BRCA testing can cause anxiety and sometimes gives confusing results, finding mutations that might not be dangerous — things the counselors are trained to interpret. There’s a shortage of genetic counselors, particularly in rural areas, and she said counseling by phone can work. There’s a wide array of gene tests, some that search just for BRCA mutations and others that test dozens of additional genes at the same time. There’s even a direct-to-consumer kit sold by 23andMe — but Domchek and Robson warned it only detects the three mutations found most in women of Ashkenazi Jewish descent, not dozens of other mutations. ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. Claim: Guidelines say more women may need breast cancer gene test.
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More women may benefit from gene testing for hereditary breast or ovarian cancer, especially if they’ve already survived cancer once, an influential health group recommended Tuesday.


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Paragraph: On June 21 2020, the Facebook page “The Runic Witch” shared the following meme, which described a garden in England “dedicated entirely to plants that … can kill you”:At the bottom of the meme was a photograph of a black gate, the archway of which read “The Poison Garden.” Both doors featured a skull and crossbones symbol and the words “these plants can kill.” Text at the top read:There’s a garden in England dedicated entirely to plants that are deadly and can kill you. It’s the most dangerous garden in the world. It holds over 100 killers [such as hemlock], strychnine, and nightshade.The Alnwick Garden is a “complex of formal gardens” not far from the Scottish border. It contains a number of sub-sections, including a massive treehouse, a cherry orchard, a bamboo labyrinth, and water features:Number nine on the above “Map Key” is marked to the left of the center fountain, and a rendering of the iron gates seen in the meme is visible.The Poison Garden was added in 2005, and a page on the Garden’s visitor site says of the deadlier plant section:The Alnwick Garden plays host to the small but deadly Poison Garden—filled exclusively with around 100 toxic, intoxicating, and narcotic plants. The boundaries of the Poison Garden are kept behind black iron gates, only open on guided tours.Visitors are strictly prohibited from smelling, touching, or tasting any plants, although some people still occasionally faint from inhaling toxic fumes while walking in the garden.An archived version of the page shed a bit more light onto the garden’s creation:It’s not often that the Home Office becomes involved with plants in the setting of a public garden, but in this instance a number of the ‘inmates’ have to have their very own license in order to be there at all.Many of the plants are already well-known for their medicinal properties, but as its creator, the Duchess of Northumberland said:‘I wondered why so many gardens around the world focused on the healing power of plants rather than their ability to kill… I felt that most children I knew would be more interested in hearing how a plant killed, how long it would take you to die if you ate it and how gruesome and painful the death might be.’Another since updated section, titled “Intoxicating inhabitants,” described some of the plants growing in the garden as the ones mentioned in the meme:There are over 100 plants of varying deadliness grown in the Poison Garden. Some of the plants are beautiful despite being deadly, and other look so harmless it is hard to imagine their dangerous, even fatal, qualities.Nux vomica’s Latin name implies much, but it perhaps rings more bells as strychnine. Interestingly, hemlock, a poison in its own right, can be used as an antidote to Strychnine, but don’t tell Socrates, who was sent to his death with a cup of hemlock.Those of a certain age will be familiar with Castor Oil, which is made from the plant Ricinus communis, but a single seed from the same plant will kill an adult in the most horrible way. Ricin causes nausea, severe vomiting, convulsions and subsequent disintegration of the kidneys, liver and spleen…In 2014, Smithsonian Magazine profiled the Poison Garden and spoke to Jane Percy, the Duchess of Northumberland about the macabre project’s inspiration:The duchess thought she might want to include an apothecary garden, but a trip to Italy set her on a slightly different course. After visiting the infamous Medici poison garden, the duchess became enthralled with the idea of creating a garden of plants that could kill instead of heal. Another trip—this one to the archeological site of the largest hospital in medieval Scotland, where the duchess learned about soporific sponges soaked in henbane, opium and hemlock used to anesthetize amputees during 15th-century surgeries—reinforced her interest in creating a garden of lethal plants.“I thought, ‘This is a way to interest children,'” she says. “Children don’t care that aspirin comes from a bark of a tree. What’s really interesting is to know how a plant kills you, and how the patient dies, and what you feel like before you die.”[…]“What’s extraordinary about the plants is that it’s the most common ones that people don’t know are killers,” the duchess says. Visitors are often surprised to learn that the laurel hedge, nearly ubiquitous in English gardens, can be highly toxic. But some visitors have had experience with laurel’s sinister side—the duchess has heard a few talk about how, after loading up their cars with pruned laurel leaves to take to the dump, drivers have fallen asleep behind the wheel of their car from the toxic fumes the branches emit.In the meme, plants in the nightshade family (which also contains potatoes, tomatoes, and eggplant) were mentioned. In the article, a more specific explanation appeared alongside a detail about the garden’s other interesting inhabitants:As part of the Poison Garden’s educational mission, the duchess grows a variety of drugs, from cannabis to cocaine (derived from the leaves of the coca plant), which she and garden guides use as a jumping-off point for drug education. “It’s a way of educating children without having them realize they’re being educated,” she says.Other poisonous plants might be less well-known to visitors, but are no less potent. One of the duchess’s favorite plants is Brugmansia, or angel’s trumpet, a member of the Solanaceae family (which includes deadly nightshade) that grows in the wild in South America. “It’s an amazing aphrodisiac before it kills you,” she says, explaining that Victorian ladies would often keep a flower from the plant on their card tables and add small amounts of its pollen to their tea to incite an LSD-like trip. “[Angel’s trumpet] is an amazing way to die because it’s quite pain-free,” the duchess says. “A great killer is usually an incredible aphrodisiac.”As such, the “Poison Garden” meme was both popular and largely accurate. The Poison Garden is a sub-attraction as part of the larger Alnwick Garden, and it is grown behind the depicted, imposing iron gates. Among the deadly plants in it are hemlock, Nux vomica (strychnine), and Ricinus communis (ricin).Comments Claim: There's a garden in England dedicated entirely to plants that are deadly and can kill you. It's the most dangerous garden in the world. It holds over 100 killers [such as hemlock], strychnine, and nightshade.
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Is There a Garden in England Dedicated Solely to Deadly Plants Called the ‘Poison Garden’?


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Paragraph: The FDA’s Wednesday announcement of the visit, planned for February 10-18, comes less than two weeks after the FDA banned products from a fourth facility owned by Indian drugmaker Ranbaxy Laboratories Ltd due to manufacturing violations, effectively shutting the company out of the U.S. market for the foreseeable future. India is the second-largest exporter of drugs to the United States after Canada and the eighth-largest food exporter. Indian companies supply 40 percent of all drugs consumed in the United States, yet quality control problems have been rampant. Hamburg said the purpose of her visit is to “connect with my counterparts in the regulatory agencies as well as have a chance to talk with industry leaders who are important stakeholders in terms of our activities.”  She plans to visit Delhi, Mumbai and Cochin, where she will attend the World Spice Congress which runs from February 16-19. She will also visit a seafood processing facility and a spices facility. India accounted for 16 percent of U.S. spice imports by value in 2010 according to a recent FDA report, more than any other country. However, spice imports have been a source of food contamination. In October the FDA released figures showing that nearly 7 percent of all spice imports examined between 2007 and 2009 were contaminated with salmonella, while 12 percent of imported spices were contaminated with insects, hair and other filth. Mexico and India accounted for the highest percentage of contaminated shipments. Hamburg said she wants to build both professional relationships with her counterparts “and build the personal bonds as well.”  “We plan to sign a fairly broad memorandum of understanding to strengthen the ongoing working relationship,” she said. “It will be a fairly broad umbrella framework but will be important both practically and symbolically.”  She said she will not be visiting individual drug companies, but will have a round-table discussion with drug company chief executives. Part of the discussion will focus on quality control. “We have made it very clear that we have a set of quality standards that we will adhere to,” Hamburg said, adding that the message will be reiterated. “It needs to be a very clear message, but it is a message they will not be surprised by.”  In December Jubilant Life Sciences Ltd received a warning letter from the FDA over manufacturing practices at one of its U.S. facilities. In November the FDA effectively banned products from a second plant operated by Wockhardt Ltd.  “We have a responsibility to ensure quality, whether of drugs manufactured in this country or outside our borders,” Hamburg said. Claim: As quality control violations rise, FDA chief heads to India.
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The commissioner of the U.S. Food and Drug Administration, Dr. Margaret Hamburg, plans to visit India for the first time in an official capacity next week as the agency works to keep sub-standard food and drugs from entering the United States.