Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

[Q]: Paragraph: The death toll increased by 683 on Wednesday. That was lower than a spike of 743 on Tuesday but more than the totals of the previous two days and the third highest daily tally since the outbreak emerged in northern regions on Feb. 21. Italy has seen more fatalities than any other country, with latest figures showing that 7,503 people have died from the infection in barely a month. The northern region of Lombardy, by far the hardest-hit, showed a steep decline in the number of deaths and new infections on Wednesday, raising hopes that the epidemic may be slowing at its original epicentre. However, optimism was tempered by warnings from the south, where contagion and deaths are far less widespread but are rising steadily, and could overwhelm a health service which is much less well equipped than in the rich north. “At this point there is the real prospect that Lombardy’s tragedy is about to become the south’s tragedy,” Vincenzo De Luca, president of the Campania region around Naples, wrote in an open letter to Prime Minister Giuseppe Conte. “We are on the eve of a major expansion of infections which may not be sustainable,” he said, complaining that the central government had failed to provide Campania with promised ventilators and other life-saving equipment. So far there have been 74 deaths in Campania, the worst affected southern region. The central region of Lazio, around the capital Rome, has registered 95 fatalities. The total number of confirmed cases in Italy rose to 74,386 from a previous 69,176, the Civil Protection Agency said. The rise of 7.5% was the lowest since the outbreak began, but only severely ill people are being tested and the head of the agency, Angelo Borrelli, said this week that the true number of infections was probably 10 times those officially recorded. Borrelli was not present at the customary news conference to illustrate the latest figures because he came down with a fever on Wednesday and was himself being tested for coronavirus. With Italy in lockdown for the last two weeks and its economy on its knees, Conte on Wednesday promised a second stimulus package in April worth at least as much as the 25 billion euro ($27.17 billion) one he adopted in March. With his approval ratings at record highs, the prime minister appealed to the opposition to get behind the government’s efforts and halt its attacks on his handling of the crisis until it is over. “There will be a time for everything, but now is the time for action and responsibility,” he told the Chamber of Deputies. One source of potential conflict for Conte was defused on Wednesday when the government reached an agreement with trade unions who had threatened strikes because they wanted more companies shuttered to protect workers’ health. Conte agreed to extend the production sectors that will be  temporarily closed because they are not deemed essential to the country’s supply chain. Claim: Italy coronavirus deaths pass 7,500 amid fears of spread to south.
[A]: More than 680 people have died from coronavirus in Italy in the last 24 hours, the Civil Protection Agency said on Wednesday, as concerns grew that the disease was spreading more towards the south of the country.


[Q]: Paragraph: True, the news hit hard last month that the so-called “Boston patients” - two men who received bone marrow transplants that appeared to rid them completely of the AIDS-causing virus - had relapsed and gone back onto antiretroviral treatment. But experts say the disappointment could lay the basis for important leaps forward in the search for a cure. “It’s a setback for the patients, of course, but an advance for the field because the field has now gained a lot more knowledge,” said Steven Deeks, a professor and HIV expert at the University of California, San Francisco. He and other experts say the primary practical message is that current tests designed to detect even very low levels of HIV present in the body are simply not sensitive enough. As well as having the human immunodeficiency virus (HIV), the Boston patients both also had a type of blood cancer called lymphoma, for which they were treated using bone marrow transplants - one man in 2008 and the other in 2010. They continued taking the antiretroviral AIDS drugs, but eight months after each patient’s transplant, doctors found they could not detect any sign of HIV in their blood. In the early part of 2013, both patients decided to stop taking their AIDS drugs and both appeared to remain HIV-free - prompting their doctors, Timothy Henrich and Daniel Kuritzkes from Boston’s Brigham and Women’s Hospital, to announce at a conference in July that they may have been cured. Yet in December came news that one of the men had begun to show signs of an HIV rebound by August, while the second patient had a relapse in November. Henrich said the virus’ comeback underlined how ingenious HIV can be in finding hiding places in the body to evade attack efforts by the immune system and by drug treatment. “Through this research we have discovered the HIV reservoir is deeper and more persistent than previously known and that our current standards of probing for HIV may not be sufficient,” he said, adding that both patients were “currently in good health” and back on antiretroviral therapy. Barely a decade ago, few HIV scientists would have dared put the words HIV and cure in the same sentence. Yet some intriguing and inspiring cases in recent years mean many now believe it is just a question of time before a cure is found. First was the now famous case of Timothy Ray Brown, the so-called “Berlin patient,” whose HIV was eradicated by a complex treatment for leukemia in 2007 involving the destruction of his immune system and a stem cell transplant from a donor with a rare genetic mutation that resists HIV infection. Such an elaborate, expensive and life-threatening procedure could never be used as a broad-spectrum approach for the world’s 34 million HIV patients. But the results in Brown focused scientific attention on a genetic mutation known as ‘CCR5 delta 32’ as a target for possible gene therapy treatment. Then last March, French scientists who followed 14 HIV-positive people known as the “Visconti patients”, who were treated very swiftly with HIV drugs but then stopped treatment, said that even after seven years off therapy, they were still showing no signs of the virus rebounding. That announcement came only weeks after news of the “functional cure” of an HIV-positive baby in Mississippi who received antiretroviral treatment for 18 months from the day she was born. By the time she was two this appeared to have stopped the virus replicating and spreading. A “functional cure” is when HIV is reduced to such low levels that it is kept at bay even without treatment, though the virus can still be detected in the body. Sharon Lewin, an HIV expert at Monash University in Australia, said all these developments, as well as the setback suffered by the Boston patients, inspired scientists to investigate many different approaches in the search for a cure. “We’ve learnt many things here - and one of the most important is that a tiny, tiny amount of virus can get the whole thing going again,” she told Reuters. “It’s a clear message that we need better ways to pick up the virus.”  Scientists are now more convinced than ever that a two-pronged approach which aims to firmly suppress the virus while bolstering the immune system provides the best way forward. “We need to attack in two ways - reduce the virus to very low levels and also to boost the immune response. We can’t do one without the other,” said Lewin. “So we still have to think of other creative ways to control HIV. And it’s still early days... before we can say which approach is likely to be the winner.” Claim: Relapse of 'cured' HIV patients spurs AIDS science on.
[A]: Scientists seeking a cure for AIDS say they have been inspired, not crushed, by a major setback in which two HIV positive patients believed to have been cured found the virus re-invading their bodies once more.


[Q]: Paragraph: Despite being used both recreationally and medicinally for millennia, the mechanisms by which cannabis affects the human body have only recently come to light. The most significant development in this body of work is the discovery of what scientists term the “endocannabinoid system,” a collection of chemical pathways found in mammals whose existence wasn’t demonstrated until the 1990s. The endocannabinoid system is made up of specific receptors that are primarily affected by chemicals already in your body — endocannabinoids. As it turns out, many of the chemicals in cannabis, termed “phytocannabinoids”, are nearly identical to the endocannabinoids already present and can therefore also affect these receptors as well if they make their way into your bloodstream. The most famous of these chemicals is tetrahydrocannabinol (commonly known as THC), which produces the psychoactive “high” people seek when they use the drug recreationally. Later research has yielded the discovery of a plethora of other phytocannabinoids that do not produce a psychoactive effect, but do demonstrate therapeutic potential. The most notable of these “other” chemicals is cannabidiol (referred to as CBD), which studies suggest has strong pain-relieving and anti-inflammatory properties, and has been shown essentially to halt seizures caused by the neurologic condition Dravet’s Syndrome. A 2008 paper published in Proceedings of the National Academy of Sciences suggested that CBD acted on a previously undescribed endocannabinoid receptor, GPR55, and that this receptor likely plays a role in the regulation of bone mass by inhibiting the growth of cells — osteoclasts — that promote the resorption of bone minerals: Our observations also suggest that CBD can inhibit bone resorption in vivo via modulation of GPR55 signaling. They go on to suggest, however, that because THC has the opposite effect on this receptor, that this interaction may negate the positive effects on bone density caused by CBD: Our observations suggest that blocking GPR55 also may have direct beneficial effects on bone turnover in arthritic or metabolic bone diseases. Finally, although CBD is a major constituent of cannabis, it remains to be determined whether cannabis smoking may increase bone density, because [THC], another constituent, also is thought to be a GPR55 ligand and may oppose the effects of CBD. In this context, two studies took a closer look at the possible mechanisms by which CBD, specifically, might help bones heal from a fracture. A 2014 study published in Biochemical Pharmacology that utilized isolated cells suggested that CBD may activate a receptor in the endocannabinoid system (CB2) that enhances the migration of mesenchymal stem cells (which play a role in creating calcified bones) to the site of the fracture. A 2015 study published in the Journal of Bone and Mineral Research reaffirmed the possibility that CBD can help with healing fractures: Here we report that the major non-psychoactive cannabis constituent, cannabidiol (CBD), enhances the biomechanical properties of healing rat mid-femoral fractures. The maximal load and work-to-failure, but not the stiffness, of femurs from rats given a mixture of CBD and Δ9-tetrahydrocannabinol (THC) for 8 weeks were markedly increased by CBD. They found that, indeed, CBD increased the strength of the healed broken femurs of laboratory rats. The authors noted that CBD, with all other constituents removed, was more effective. They suggest a different mechanism for this effect: CBD increases the expression of a gene that codes for a series of reactions that results in the production of collagen, which is then transformed into harder bone material, a process termed collagen cross-linking. Each of these three mechanisms that link CBD to bone physiology has support in the scientific community, as attested to by their inclusion in a September 2016 review of phytocannabinoid pharmacology in the journal Physiological Reviews. It is important to note, however, that CBD specifically, and not the cannabis plant as a whole, is implicated in the therapeutic effects on bones. As such, consuming just any cannabis would not necessarily be effective. Any treatment would require an effort to isolate or increase the concentration of CBD and remove or reduce THC. Claim: Scientific studies support the conclusion that marijuana can play a role in healing broken bones.
[A]:
It is also important to note that this is an ongoing area of investigation hampered by legal restrictions on research, that few large-scale studies have been performed, and that these studies are dominantly on laboratory animals or isolated cells, not on humans.