TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disease in adults. Classical ALS is characterized by the death of upper and lower motor neurons leading to progressive paralysis. Approximately 10% of ALS patients have familial form of the disease. Numerous different gene mutations have been found in familial cases of ALS, such as mutations in superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP-43), fused in sarcoma (FUS), C9ORF72, ubiquilin-2 (UBQLN2), optineurin (OPTN) and others. Multiple animal models were generated to mimic the disease and to test future treatments. However, no animal model fully replicates the spectrum of phenotypes in the human disease and it is difficult to assess how a therapeutic effect in disease models can predict efficacy in humans. Importantly, the genetic and phenotypic heterogeneity of ALS leads to a variety of responses to similar treatment regimens. From this has emerged the concept of personalized medicine (PM), which is a medical scheme that combines study of genetic, environmental and clinical diagnostic testing, including biomarkers, to individualized patient care. In this perspective, we used subgroups of specific ALS-linked gene mutations to go through existing animal models and to provide a comprehensive profile of the differences and similarities between animal models of disease and human disease. Finally, we reviewed application of biomarkers and gene therapies relevant in personalized medicine approach. For instance, this includes viral delivering of antisense oligonucleotide and small interfering RNA in SOD1, TDP-43 and C9orf72 mice models. Promising gene therapies raised possibilities for treating differently the major mutations in familial ALS cases.

SOLUTION: Which human disease is associated with mutated UBQLN2

PROBLEM: In 1991, the governments of the U.S. and China are on the verge of a major trade agreement, with the President of the United States due to visit China to seal the deal. The CIA learns that its asset Tom Bishop (Brad Pitt) has been captured trying to free a Briton, Elizabeth Hadley (Catherine McCormack), from a People's Liberation Army prison in Su Chou near Shanghai, China. Bishop is being questioned under torture and will be executed in 24 hours unless the U.S. government claims him. If the CIA claims Bishop as an agent, they risk jeopardizing the trade agreement. Exacerbating Bishop's situation is the fact that he was operating without permission from the Agency. Attempting to deal quickly with the situation, CIA executives call in Nathan Muir (Robert Redford), an aging mid-level case officer on his last day before retirement and the man who recruited Bishop. Although they tell Muir they simply need him to act as a "stop gap" to fill in some holes in their background files, the officials are hoping he will give them the pretext they need to justify letting Bishop die. The CIA executives are unaware that Muir had been tipped off about Bishop's capture prior to arriving at the CIA's headquarters, by fellow CIA veteran Harry Duncan (David Hemmings), for whom Bishop had been working an operation in Hong Kong before going rogue. Muir first attempts to save Bishop by leaking the story to CNN through a contact in Hong Kong, believing that public pressure would force the CIA to rescue Bishop. The tactic only stalls them, however, and is stymied when a phone call to the U.S. Federal Communications Commission from CIA Deputy Director Charles Harker (Stephen Dillane) results in CNN retracting the story. During the debriefing, Muir describes how he recruited Bishop for an operation when Bishop was a U.S. Marine scout sniper during the Vietnam War. Muir also discusses their 1976 tour of duty in Berlin, Germany, where Bishop was tasked with procuring East German assets, with Muir commanding, as well as Bishop's spy work in Beirut, Lebanon in 1985 during the War of the Camps, the latter being the last time the two saw each other. During the mission in Lebanon, Bishop met Hadley, and the two began developing romantic feelings for each other. However, it is revealed that Hadley was involved in a bombing of the Chinese embassy in Britain, causing her to flee the country. Fearing that Bishop's feelings for Hadley might compromise his cover and the mission, Muir tips off the Chinese to Hadley's location in return for freeing an arrested U.S. diplomat. Chinese agents kidnap Hadley, and Bishop cuts all ties to Muir when he discovers his involvement. After learning Hadley was the target of Bishop's rescue attempt, Muir finally realizes that he has greatly underestimated Bishop's feelings for her. Running out of time, Muir secretly creates a forged urgent operational directive from the CIA director to commence Operation Dinner Out, a rescue mission to be spearheaded by Commander Wiley's (Dale Dye) U.S. Navy SEAL team, for which Bishop had laid the groundwork as a "Plan B" for his own rescue attempt. Using US$282,000 of his life savings and a misappropriated file on Chinese coastline satellite imagery, Muir enlists Duncan's help in bribing a Chinese energy official to cut power to the prison for 30 minutes, during which time the SEAL rescue team retrieves Bishop and Hadley. Bishop, who is rescued at the end of the film 15 minutes before his scheduled execution, realizes Muir was behind his rescue when he recognizes the name of the plan to rescue him, Operation Dinner Out: a reference to a birthday gift that Bishop gave Muir while they were in Lebanon. When the CIA officials are belatedly informed of the rescue, Muir has already left the building and is seen driving off into the countryside.

SOLUTION: Whats the name of the English woman?

PROBLEM: Reflection is one of several ways that light can interact with matter. Light reflects off surfaces such as mirrors that do not transmit or absorb light. When light is reflected from a smooth surface, it may form an image. An image is a copy of an object that is formed by reflected (or refracted) light. Q: Is an image an actual object? If not, what is it? A: No, an image isnt an actual object. It is focused rays of light that make a copy of an object, like a picture projected on a screen. If a surface is extremely smooth, as it is in a mirror, then the image formed by reflection is sharp and clear. This is called regular reflection (also called specular reflection). However, if the surface is even slightly rough or bumpy, an image may not form, or if there is an image, it is blurry or fuzzy. This is called diffuse reflection. Q: Look at the boats and their images in the Figure 1.1. Which one represents regular reflection, and which one represents diffuse reflection? A: Reflection of the boat on the left is regular reflection. The water is smooth and the image is sharp and clear. Reflection of the boat on the right is diffuse reflection. The water has ripples and the image is blurry and wavy. In the Figure 1.2, you can see how both types of reflection occur. Waves of light are represented by arrows called rays. Rays that strike the surface are referred to as incident rays, and rays that reflect off the surface are known as reflected rays. In regular reflection, all the rays are reflected in the same direction. This explains why regular reflection forms a clear image. In diffuse reflection, the rays are reflected in many different directions. This is why diffuse reflection forms, at best, a blurry image. One thing is true of both regular and diffuse reflection. The angle at which the reflected rays leave the surface is equal to the angle at which the incident rays strike the surface. This is known as the law of reflection. The law is illustrated in the Figure 1.3.

SOLUTION:
rays of light are reflected in many different directions in