instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: Immunization of pigs with a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine initially elicits a weak interferon (IFN)-g response. To improve the immune response, an adjuvant consisting of plasmid encoding either porcine interleukin (IL)-12 or IFN-a was co-administered during vaccination. In the presence of either adjuvant, at least a threefold increase in the primary virus-specific IFN-g response was observed. While this enhancement was only transient (1 week) when the IL-12 expressing plasmid was used, the effect was not only still apparent at 6 weeks after vaccination in the presence of the IFN-a expressing plasmid but even after challenge with a virulent genetically divergent PRRSV. In contrast, no effect of either adjuvant on the production of anti-virus antibodies was noticed throughout the study. Despite the apparent augmentation of a T helper (Th) 1 type response by the inclusion of IFN-a or IL-12 during vaccination, this modulation did not necessarily correlate with a reduction in viremia. Since a similar increase in the degree of the IFN-g response to the PRRSV vaccine could be achieved by substituting polyinosinic-polycytidylic acid in lieu of either cytokine, exposure to PRRSV in the presence of a variety of Th 1 polarizing molecules can positively influence the development of the cell-mediated immune response of swine to this pathogen. Conceivably, such intervention could be applied to improve the formulation of anti-PRRSV vaccines. # 
 Title: Cytokines and synthetic double-stranded RNA augment the T helper 1 immune response of swine to porcine reproductive and respiratory syndrome virus
answer:
True


question:
Paragraph: Objectives. To critically appraise the efficacy and safety of Kangfuxinye enema combined with mesalamine for the ulcerative colitis (UC) patients and in addition to grade the quality of evidence by using the GRADE (grading of recommendations, assessment, development, and evaluation) approach. Methods. A literature search was performed in the Cochrane Library, MEDLINE, EMBASE, CBM, CNKI, VIP, and WanFang Databases. The search restrictions were patients with UC and RCTs. Studies including other treatments except Kangfuxinye with mesalamine were excluded. Results. Nineteen studies met the inclusion criteria. We found significant benefits of Kangfuxinye combined with mesalamine against mesalamine alone in improving response rate as well as reducing the recurrence rate and inflammation rate; meanwhile, the increase of the adverse events rate was not observed. Furthermore, the symptoms remission rate and the cure time were insignificant statistically. Additionally, GRADE results indicated that the quality of evidence regarding the above 6 outcomes was rated from very low to moderate quality. Conclusions. Although Kangfuxinye enema seems effective and safe for treating UC patients in this systematic review, Kangfuxinye enema combined with mesalamine was weakly recommended due to very low to moderate quality of available evidence by the GRADE approach. 
 Title: Kangfuxinye Enema Combined with Mesalamine for Ulcerative Colitis: A Systematic Review and GRADE Approach
answer:
True


question:
Paragraph: Ebolaviruses are non-segmented, negative-sense RNA viruses (NNSVs) within the order 19 Mononegavirales that possess the multifunctional virion protein 35 (VP35), a major determinant 20 of virulence and pathogenesis that is indispensable for viral replication and host innate immune 21 evasion. VP35 is functionally equivalent to the phosphoprotein (P) of other mononegaviruses 22 such as rhabdoviruses and paramyxoviruses. Phosphorylation of the P protein is universally 23 regarded as functionally important however, a regulatory role(s) of phosphorylation on VP35 24 function remains unexplored. Here, we identified a highly conserved Ser129 residue near the 25 homo-oligomerization coiled coil motif, which is essential for VP35 functions. Affinity-purification 26 MS followed by post-translational modification (PTM) analysis predicted phosphorylation of 27 Ser129. Co-immunoprecipitation, cross-linking, and biochemical characterization studies 28 revealed a moderately decreased capacity of VP35-S129A to oligomerize. Functional analysis 29 showed that Ser-to-Ala substitution of Ebola virus (EBOV) VP35 did not affect IFN inhibitory 30 activity but nearly abolished EBOV minigenome activity. Further coimmunoprecipitation studies 31 demonstrated a lost interaction between VP35-S129A and the amino terminus of the viral 32 polymerase but not between viral nucleoprotein (NP) or VP35-WT. Taken together, our findings 33 provide evidence that phosphorylation modulates VP35 function, supporting VP35 as a NNSV P 34 protein and providing a potentially valuable therapeutic target. 35 Importance 36 Ebola virus (EBOV) can cause severe disease in humans. The 2013-2016 West African 37 epidemic and the two recent outbreaks in the Democratic Republic of the Congo underscore the 38 urgent need for effective countermeasures, which remain lacking. A better understanding of 39 EBOV biology and the modulation of multifunctional viral proteins is desperately needed to 40 develop improved therapeutics. We provide evidence here that function of virion protein 35 41 (VP35) is modulated by phosphorylation of Ser129, a conserved residue among other 42 ebolavirus species. These findings shed light on EBOV biology and present a potential target for 43 broad acting anti-ebolavirus therapeutics. 44 45 46 47 48 49 
 Title: Mutation of Ebola virus VP35 Ser129 uncouples interferon antagonist and replication functions
answer:

True