Given a passage classify if the passage has a definite objective/aim/goal or not. Output '1' if the passage has a defininte objective/aim/goal and output '0' if the passage does not have a definite objective/aim/goal.

Q: B-type natriuretic peptide (BNP)-natriuretic peptide receptor A (NPR-A) receptor signalling inhibits cardiac sympathetic neurotransmission, although C-type natriuretic peptide (CNP) is the predominant neuropeptide of the nervous system with expression in the heart and vasculature. We hypothesized that CNP acts similarly to BNP, and that transgenic rats (TGRs) with neuron-specific overexpression of a dominant negative NPR-B receptor would develop heightened sympathetic drive.', 'Mean arterial pressure and heart rate (HR) were significantly (P\u2009<\u20090.05) elevated in freely moving TGRs (n\u2009=\u20099) compared with Sprague Dawley (SD) controls (n\u2009=\u200910). TGR had impaired left ventricular systolic function and spectral analysis of HR variability suggested a shift towards sympathoexcitation. Immunohistochemistry demonstrated co-staining of NPR-B with tyrosine hydroxylase in stellate ganglia neurons. In SD rats, CNP (250\u2009nM, n\u2009=\u20098) significantly reduced the tachycardia during right stellate ganglion stimulation (1-7\u2009Hz) in vitro whereas the response to bath-applied norepinephrine (NE, 1\u2009μM, n\u2009=\u20096) remained intact. CNP (250\u2009nM, n\u2009=\u20098) significantly reduced the release of 

A: 1
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Q: Thromboembolic events represent a clinically significant cause of neurological morbidity during the endovascular management of cerebral aneurysms. We have implemented an anti-thromboembolic regimen consisting of pre- and postoperative dual antiplatelet therapy, as well as postoperative anticoagulation using heparin and dextran. The aims of our study were to examine the effect of this regimen on thromboembolic rates during elective aneurysm coiling, and to elucidate risk factors associated with the development of thromboembolic events in this setting.', 'We conducted a retrospective review of patients who underwent elective intracranial aneurysm coiling between January 2005 and February 2012. The primary outcome of interest was the occurrence of a clinically significant peri-procedural thromboembolic event. Secondary outcomes included the occurrence of a central nervous system (CNS) or systemic hemorrhage.', 'During the study period, 312 patients underwent elective aneurysm coiling and six (2\xa0%) thromboembolic events occurred; three (1\xa0%) occurred in the group that received the anti-thromboembolic regimen (261 patients) and three (6\xa0%) occurred in the group that did not receive the regimen (51 patients), resulting in a statistically significant difference (P\u2009=\u20090.024). Both the presence of a hypercoagulable state (P\u2009=\u20090.014) and the lack of the anti-thromboembolic regimen (P\u2009=\u20090.043) were significantly associated with the occurrence of a thromboembolic event.

A: 0
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Q: Patients undergoing cardiac surgery employing cardiopulmonary bypass frequently require transfusion of homologous blood products and, therefore, are exposed to the risk of transfusions. Autologous platelet-rich plasma administration may reduce homologous transfusion and attendant risks.', 'In a blinded, randomized fashion, patients undergoing repeat sternotomy and valvular surgery received either a sham product (n = 28) or autologous platelet-rich plasma (n = 28) at the conclusion of cardiopulmonary bypass. Perioperative blood loss, coagulation profiles, and transfusion requirements were compared between the two groups.', 'In the first 24 h postoperatively, both the platelet-rich plasma and sham groups received a median of 10.5 units of homologous blood products. Total median perioperative homologous transfusion requirements were 13 and 11.5 units for the platelet-rich plasma and sham groups, respectively. There was no significant difference in intraoperative or postoperative bleeding between the groups.

A:
0
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