Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
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Question: Thiopurine methyltransferase deficiency occurs at a frequency of one in 300 and is associated with profound myelosuppression after a short course of azathioprine.

Answer: adverse drug event


Question: A challenge with clozapine was feasible and showed no clinical symptoms of eosinophilia.

Answer: non-adverse drug event


Question: Interstitial granulomatous dermatitis associated with darifenacin.

Answer:
adverse drug event