Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

Q: Question: Does long-term treatment with methotrexate or tumor necrosis factor alpha inhibitors increase epstein-barr virus load in patients with rheumatoid arthritis?
Answer: Long-term usage of methotrexate or TNFalpha inhibitors in patients with RA does not significantly influence EBV load in PBMCs.

A: no
****
Q: Question: Does interaction of programmed death-1 and programmed death-1 ligand-1 contribute to testicular immune privilege?
Answer: The constitutive expression of PD-L1 in the testis is an important mechanism underlying testicular immune privilege and long-term survival of intratesticular islet allografts.

A: yes
****
Q: Question: Is t-cell receptor diversity selectively skewed in T-cell populations of patients with Wiskott-Aldrich syndrome?
Answer: Our results indicate that WAS gene mutations selectively influence TCR repertoire development or expansion in CD45RO(+) (memory) CD4(+) T cells.

A:
yes
****