In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: Pyruvate carboxylase is allosterically activated by one of the following compounds, what is it? 
 Options:  <1> Pyruvate. <2> Acetyl-CoA. <3> Malate. <4> Oxalacetate. <5> NAD +.
2

Question: 78-year-old man with poorly controlled rheumatoid arthritis (RA). A history of 2 admissions for heart failure and atrial fibrillation in the last 6 months. In current treatment with infliximab, prednisone, furosemide, enalapril, carvedilol and acenocoumarol. Enter again for biventricular heart failure clinic. The ECG showed atrial fibrillation at 102 bpm and advanced left bundle branch block. An echocardiogram shows biatrial dilation, thickening of the left ventricular wall with ejection fraction of 45% and restrictive pattern. The analytical highlights: Hb 10 gr / dL, creatinine 2.1 mg / dL (FG 20 mL / min), CRP 124 mg / L, rheumatoid factor 240 U / L, BNP 980 ng / L, proteinuria 4.8 g / 24h. What is the most likely diagnosis? 
 Options:  <1> Cardio-renal syndrome type 2. <2> Amyloidosis AA. <3> Myocarditis of giant cells. <4> Toxicity due to infliximab. <5> Membranous glomerulonephritis associated with RA.
2

Question: A 54-year-old man diagnosed with diabetes mellitus type 2 came to our clinic. He reported fever of 40ºC with chills and shivering, arthromyalgia and headache, which is why he started treatment with paracetamol. The painting began 24 hours before his return to Spain. After 3 days, he presented with a generalized maculo-papular rash that progressed to the formation of more intense petechiae in the lower limbs. It provides analytics where leukopenia stands out with 3,200 / mm3 and platelets 91,000 / mm3 and mild elevation of aminotransferases. Thickness, peripheral blood smear, polymerase chain reaction (PCR) and malaria antigen are negative. What is the most likely suspected diagnosis? 
 Options:  <1> Coronavirus infection. <2> Lymphocyte choriomeningitis. <3> Dengue. <4> Chikungunya virus infection. <5> Encephalitis of Saint Louis.

3