In this task, You are given an open-domain question that can be answered based on factual information. Your task is to provide \*short\* answer (in a few words only) for the given question. The short answer can be one or more entities or it can also be boolean \*yes\* or \*no\*.

[EX Q]: when was the first game of thrones made
[EX A]: 2009

[EX Q]: at the end of the hundred years war the english only held
[EX A]: Calais

[EX Q]: where does a substrate fit into an enzyme
[EX A]:
the active site