instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Missense mutations in ubiquilin 2 (UBQLN2) cause ALS with frontotemporal dementia (ALS-FTD). Animal models of ALS are useful for understanding the mechanisms of pathogenesis and for preclinical investigations. However, previous rodent models carrying UBQLN2 mutations failed to manifest any sign of motor neuron disease. Here, we show that lines of mice expressing either the ALS-FTD-linked P497S or P506T UBQLN2 mutations have cognitive deficits, shortened lifespans, and develop motor neuron disease, mimicking the human disease. Neuropathologic analysis of the mice with end-stage disease revealed the accumulation of ubiquitinated inclusions in the brain and spinal cord, astrocytosis, a reduction in the number of hippocampal neurons, and reduced staining of TAR-DNA binding protein 43 in the nucleus, with concomitant formation of ubiquitin
answer:
Which human disease is associated with mutated UBQLN2


question:
It was 1:30 a.m. Monday at London's Savoy Hotel and, with autograph books and cameras, a group of brighteyed tennis fans of all ages were waiting for just a glimpse of Maria Sharapova . The 17-year-old girl defeated champion Serena Williams 6-1 6-4 in the Wimbledon final on Saturday in London to become the first Russian to win a single title at the championships. A silver lining to a depressing, rain-hit Wimbledon, she has raised heated passion. Nobody was complaining, though, for the 1.83-metre Sharapova has created a welcome wave of interest in tennis, something missing in recent years. Not even Anna Kournikova evoked such passion when she broke on to the scene. To look good on court is one thing, but Sharapova can actually play the game too. Extremely well. She proved it over 13 days at the world's most prestigious tournament. Playing tennis of the highest quality throughout, the Russian's triumph not only lifted the tournament from fits of rain-induced depression but also salvaged(;) the season for the woman's tour. Sharapova was given no easy ride in the tournament, having to beat 1999 champion Lindsay Davenport in the semifinals and twice-champion Serena Williams for the title. Neither caused her much concern. "I don't remember too much about the final," Sharapova giggled. "I was in my own place." She will find it increasingly hard to find any place to call her own from now on after advertisers identified her as the most marketable woman in sport. In Russia she is sensational news. She headlined the news bulletins and was telephoned by former Russian President Boris Yeltsin after her triumph. Sharapova will return to her adoptive Florida home knowing life will never be the same again. But the girl who arrived in the US aged seven with her father and just US$700 is determined not to let fame and riches detract from her number one love, tennis. "I know things will start coming up and that many more things will want to get involved, but I want to keep my head cool and play tennis," she said.
answer:
Who has won the most times in Wimbledon?


question:
The officials of a city unveil a new statue, only to find The Tramp sleeping on it. They shoo him away and he wanders the streets, destitute and homeless, and is soon tormented by two newsboys. He happens upon a beautiful Flower Girl (Virginia Cherrill), not realizing at first that she is blind, and buys a flower. Just when she is about to give him his change, a man gets into a nearby luxury car and is driven away, making her think that the Tramp has departed. The Tramp tiptoes away. That evening, the Tramp runs into a drunken Millionaire (Harry Myers) who is attempting suicide on the waterfront. (It is later mentioned that his wife has sent for her bags.) The Tramp eventually convinces The Millionaire he should live. He takes the Tramp back to his mansion and gives him a change of clothes. They go out for a night on the town, where the Tramp inadvertently causes much havoc. Early the next morning, they return to the mansion and encounter the Flower Girl en route to her vending spot. The Tramp asks The Millionaire for some money, which he uses to buy all the girl's flowers and then drives her home in the Millionaire's Rolls-Royce.After he leaves, the Flower Girl tells her Grandmother (Florence Lee) about her wealthy acquaintance. When the Tramp returns to the mansion, the Millionaire has sobered and does not remember him, so has the butler order him out. Later that day, the Millionaire meets the Tramp again while intoxicated, and invites him home for a lavish party. The next morning, having sobered again and planning to leave for a cruise, the Millionaire again has the Tramp tossed out.Returning to the Flower Girl's apartment, the Tramp spies her being attended by a doctor. Deciding to take a job to earn money for her, he becomes a street sweeper. Meanwhile, the Grandmother receives a notice that she and the girl will be evicted if they cannot pay their back rent by the next day, but hides it. The Tramp visits the girl on his lunch break, and sees a newspaper story about a Viennese doctor who has devised an operation that cures blindness. He then finds the eviction notice and reads it aloud at the girl's request. He reassures her that he will pay the rent. But he returns to work late and is fired.As he is walking away, a boxer persuades him to stage a fake fight, promising to split the $50 prize money. Just before the bout, however, the man receives a telegram warning him that the police are after him. He flees, leaving the Tramp a no-nonsense replacement opponent. Despite a valiant effort, the Tramp is knocked out.Some time later, he meets the drunken Millionaire who has just returned from Europe. The Millionaire takes him to the mansion and after he hears the girl's plight, gives the Tramp $1,000. Unbeknownst to the Millionaire and the Tramp, two burglars were hiding in the house when they entered. Upon hearing about the cash, they knock out the millionaire and take the rest of his money. The Tramp telephones for the police, but the robbers flee before they arrive, and the butler assumes he stole the money. The Millionaire cannot remember the Tramp or giving him the $1,000. The Tramp narrowly escapes and gives the money to the girl saying he will be going away for a while. Later, he is arrested in front of the newsboys who taunted him earlier, and jailed.Months later, the Tramp is released. Searching for the girl, he returns to her customary street corner but does not find her. With her sight restored, the girl has opened up a flourishing flower shop with her Grandmother. When a rich customer comes into the shop, the girl briefly wonders if he is her mysterious benefactor. But when he leaves with no acknowledgement, she realizes again she is wrong. While retrieving a flower from the gutter outside the shop, the Tramp is again tormented by the two newsboys. As he turns to leave, he finds himself staring at the girl
answer:

Who knocks out the Millionaire?