Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.

Ex Input:
Not applicable. It’s understandable that costs wouldn’t be discussed at this early stage of research. Adequate explanation of results observed in study participants at different dosing levels. More importantly, the story simply explained: “Since it’s not completely clear what reductions in brain plaques mean for Alzheimer’s patients, the researchers are unable to say whether treatment with gantenerumab will bring improvement to patients with Alzheimer’s. They are currently involved in a new study that they hope will answer that question.” Better than its HealthDay competition in that WebMD actually told us how many people experienced harms in the study. The story allowed a Roche senior VP to say the results “went beyond our expectations” but countered that with “What is not entirely known is if these plaques cause Alzheimer’s…Therefore, it’s not known if reducing the amount of them will slow or stop the disease.” No disease mongering at play here. The story added an important independent perspective and identified the study co-author as being a senior VP of the drug company making the drug. We preferred how HealthDay explained:  “There are approximately one dozen therapies, including vaccines, that are currently in the pipeline….none are ready for prime time.” The story ends with an appropriate send-off:  “We need more studies to know if it is safe or effective.”  The early, experimental nature of the research is clear. The HealthDay competitor did a better job of explaining where this study fits in the history of research into beta-amyloid. There was clear evidence of independent reporting.

Ex Output:
Drug May Reduce Plaque in Brains of Alzheimer’s Patients


Ex Input:
The story makes clear the “big unknown” remains the price and “how much people are willing to spend to cut a day or so off of a bout of flu.” The story reports that Genentech, the drug’s manufacturer, said it’s too early to comment on the drug’s U.S. price. The story also notes that in Japan, where the drug was invented, it “sells for the equivalent of about $43.50.” The story uses terms like “a little more than a day” and “nearly a day” and “substantially” to describe the drug’s reduction in flu symptoms, fever, and coughing and sneezing, respectively. It does not explain, as the news release does, that: “Similar efficacy results were seen between baloxavir marboxil and [Tamiflu] in relation to duration of symptoms and fever reduction.” In other words, on the symptom front, both drugs were the same. According to the news release, a difference was seen in the length of time the virus was shed from the body (presumably through coughing and sneezing): 24 hours for baloxavir marboxil verses 72 hours for Tamiflu. The news release also states that there was also a difference seen in the level of virus in the nose and throat, but it provides no precise numbers. It is not known whether this benefit translates into less infection transmission, and the story should have made that clear. The news release issued by Genentech about the FDA’s decision to grant priority review describes baloxavir marboxil’s most common side effects: diarrhea, bronchitis, nausea and sinusitis. The news release also states that overall incidence of adverse events seen in patients taking baloxavir marboxil were lower than those seen in both the placebo group and the group taking Tamiflu. The STAT News story does not mention any potential harms. This evidence comes from the randomized phase III Capstone-1 study the FDA will review, which included 1,436 people in the US and Japan. It excluded people older than 64. The news story does not note this exclusion, nor does it state a key problem with this study: It has never been published in a peer-reviewed journal (instead, a study abstract was released as part of ID Week 2017). This means the full data analysis has never been seen by anyone other than the researchers. We explained why this is important in February 2018, when we discussed news coverage of the drug’s approval in Japan. The 2017-2018 flu season was the worst the US had experienced in nearly a decade. The flu impacted the entire country, and was responsible for 172 pediatric deaths. The news article did not use these or any other flu-related statistics to increase fear about the flu and, in turn, the need for this medication. The article includes two sources: Mark Eisner, Genentech’s VP of product development for immunology, infectious diseases and ophthalmology and Richard Webby, head of the World Health Organization’s influenza collaborating center at St. Jude Children’s Research Hospital in Memphis. Eisner’s affiliation with Genentech, the drug’s manufacturer, is clearly noted. Webby does not appear to have any conflicts of interest. The article would have been stronger if it had included a third source who commented on what–if anything–is known about whether reducing the duration of symptoms leads to reduced levels of transmission that result in fewer people contracting the flu and fewer deaths. The story explains that the only other drug approved to treat the flu is Tamiflu, which is not widely used. The writer explains that both drugs need to be taken within 48 hours of symptom onset and that baloxavir marboxil is a single one-time dose, while Tamiflu must be taken twice daily for five days. It is clear from the story that the FDA is expected to decide by the end of the year whether to approve this new flu medication. The story explains that it’s been more than 20 years since a new class of flu drug has been developed and marketed. (It is available in Japan.) The catalyst for the story was a news release issued by Genentech about the FDA granting priority review of baloxavir marboxil, but the story does not use direct quotes from the news release.

Ex Output:
A flu drug — shown to reduce the duration of symptoms — could upend treatment in U.S.


Ex Input:
Cyclone Idai smashed into Beira on March 14, unleashing catastrophic flooding and killing more than 700 people in Mozambique, Zimbabwe and Malawi. The aftermath may prove to be even deadlier with 1.85 million people displaced after entire villages were submerged and households swept away. “We’ve now registered one death from cholera. The person came here in a very critical condition. The deceased is the first to die from cholera inside our health facilities,” Mozambique’s National Director for Medical Assistance, Ussene Isse, said on public television channel TVN. Isse said 517 cases of the disease had been reported by Sunday, up from the figure of 271 announced on Saturday. Cholera is endemic to Mozambique, which has had regular outbreaks over the past five years. About 2,000 people were infected in the last outbreak, which ended in February 2018, according to the WHO. The scale of the damage to Beira’s water and sanitation infrastructure, coupled with its dense population, have raised fears that another epidemic would be difficult to put down.

Ex Output:

First cholera death recorded since cyclone hit Mozambique port, cases double.