Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
Rudolphe Cabanel (also Rudolph) (1763--1839) was a German architect, engineer and machinist, known for his work on British theatres.

Ex Output:
The date of birth for Rudolphe Cabanel is what?


Ex Input:
CC's (pronounced cee-cees) is a brand of flavoured tortilla chips produced since the early 1980s, originally by The Smith's Snackfood Company, and currently by Snack Brands Australia.

Ex Output:
The country for CC's was what?


Ex Input:
There are three major apolipoprotein E (apoE) isoforms. Although APOE-epsilon3 is considered a longevity gene, APOE-epsilon4 is a dual risk factor to atherosclerosis and Alzheimer disease. We have expressed full-length and N- and C-terminal truncated apoE3 and apoE4 tailored to eliminate helix and domain interactions to unveil structural and functional disturbances. The N-terminal truncated apoE4-(72-299) and C-terminal truncated apoE4-(1-231) showed more complicated or aggregated species than those of the corresponding apoE3 counterparts. This isoformic structural variation did not exist in the presence of dihexanoylphosphatidylcholine. The C-terminal truncated apoE-(1-191) and apoE-(1-231) proteins greatly lost lipid binding ability as illustrated by the dimyristoylphosphatidylcholine turbidity clearance. The low density lipoprotein (LDL) receptor binding ability, determined by a competition binding assay of 3H-LDL to the LDL receptor of HepG2 cells, showed that apoE4 proteins with N-terminal (apoE4-(72-299)), C-terminal (apoE4-(1-231)), or complete C-terminal truncation (apoE4-(1-191)) maintained greater receptor binding abilities than their apoE3 counterparts. The cholesterol-lowering abilities of apoE3-(72-299) and apoE3-(1-231) in apoE-deficient mice were decreased significantly. The structural preference of apoE4 to remain functional in solution may explain the enhanced opportunity of apoE4 isoform to display its pathophysiologic functions in atherosclerosis and Alzheimer disease.

Ex Output:

Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?