Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
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Question: Unusual pigmentary changes associated with 5-fluorouracil therapy.

Answer: adverse drug event


Question: We report a case of acne fulminans occurring during treatment with 13-cis-retinoic acid for cystic acne.

Answer: adverse drug event


Question: Amiodarone was approved to treat recurrent ventricular fibrillation or sustained ventricular tachyarrhythmia that has been resistant to other medications since 1986.

Answer:
non-adverse drug event