In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: The denaturation of proteins: 
 Options:  <1> It is accompanied by the loss of their activity. <2> It supposes the rupture of peptide bonds. <3> It is always an irreversible process. <4> Alter its primary structure. <5> It is carried out by chaperone proteins.
1

Question: In the oxaciclohexane-type conformer of sugar -D - (+) - glucopyranose: 
 Options:  <1> One of the OH- groups is axial, but the remaining substituents are equatorial. <2> The CH2OH group is axial but the remaining groups are equatorial. <3> All groups are axial. <4> All groups are equatorial. <5> The CH2OH group is equatorial but the remaining groups are axial.
4

Question: Question linked to the image nº6 A friend of his 37 years shows him the photograph of his own right hand that is shown in the image A. He had made a cold day in November and tells him that after a few minutes regained its normal color With a magnifying magnifying glass, look at the B image in the nail bed. What is the most likely diagnosis? 
 Options:  <1> Systemic sclerosis <2> Acrocyanosis <3> Livedo reticularis. <4> Raynaud's disease. <5> Cold agglutinin disease.

1