Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
The 80-string koto (or hachijugen) was an invention of Japanese composer Michio Miyagi which appeared In 1923.

Ex Output:
By whom was 80-string koto discovered?


Ex Input:
Chronic myeloid leukaemia (CML) is characterised by the occurrence of the Philadelphia (Ph) chromosome (9/22 translocation) and the formation of a fusion protein--the BCR-ABL transcript with constitutive activation of the BCR-ABL tyrosine kinase and consequent changes in the intracellular signal transduction, which is responsible for the deregulated myeloid cell proliferation. STI571 (signal transduction inhibition number 571) is a potent and selective inhibitor of the BCR-ABL tyrosine kinase. In the chronic phase of the disease, normal peripheral blood values are achieved within the first month of treatment in the large majority of patients and in many patients also a cytogenic response within the following months. The results in the advanced phase are far less favourable, which is explained by the development of resistance owing to reactivation of the BCR-ABL signal transduction. Side effects are primarily nausea, vomiting, various rashes, oedema, most often in the periorbital region, and musculoskeletal symptoms, including muscle cramps. Perspectives for treatment with STI571 are described, as are combinations with alpha-interferon and other cytostatics with a synergistic profile.

Ex Output:
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Ex Input:
A persons genome is all of his or her genetic information. In other words, the human genome is all the information that makes us human. And unless you have an identical twin, your genome is unique. No one else has a genome just like yours, though all our genomes are similar. The Human Genome Project ( Figure 1.1) was an international effort to sequence all 3 billion bases that make up our DNA and to identify within this code more than 20,000 human genes. Scientists also completed a chromosome map, identifying where the genes are located on each of the chromosomes. The Human Genome Project was completed in 2003. Though the Human Genome Project is finished, analysis of the data will continue for many years. To say the Human Genome Project has been beneficial to mankind would be an understatement. Exciting applications of the Human Genome Project include the following: The genetic basis for many diseases can be more easily determined. Now there are tests for over 1,000 genetic disorders. The technologies developed during this effort, and since the completion of this project, will reduce the cost of sequencing a persons genome. This may eventually allow many people to sequence their individual genome. Analysis of your own genome could determine if you are at risk for specific diseases. Knowing you might be genetically prone to a certain disease would allow you to make preventive lifestyle changes or have medical screenings. To complete the Human Genome Project, all 23 pairs of chromosomes in the human body were sequenced. Each chromo- some contains thousands of genes. This is a karyotype, a visual representation of an individuals chromosomes lined up by size. The video Our Molecular Selves discusses the human genome, and is available at or . Genome, Unlocking Lifes Code is the Smithsonian National Museum of Natural Historys exhibit on the human genome. See [Link] to visit the exhibit. Click image to the left or use the URL below. URL:

Ex Output:

analysis of your own genome