Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: The discovery of the Hippo pathway can be traced back to two areas of research. Genetic screens in fruit flies led to the identification of the Hippo pathway kinases and scaffolding proteins that function together to suppress cell proliferation and tumor growth. Independent research, often in the context of muscle biology, described Tead (TEA domain) transcription factors, which bind CATTCC DNA motifs to regulate gene expression. These two research areas were joined by the finding that the Hippo pathway regulates the activity of Tead transcription factors mainly through phosphorylation of the transcriptional coactivators Yap and Taz, which bind to and activate Teads. Additionally, many other signal transduction proteins crosstalk to members of the Hippo pathway forming a Hippo signal transduction network. We discuss evidence that the Hippo signal transduction network plays important roles in myogenesis, regeneration, muscular dystrophy, and rhabdomyosarcoma in skeletal muscle, as well as in myogenesis, organ size control, and regeneration of the heart. Understanding the role of Hippo kinases in skeletal and heart muscle physiology could have important implications for translational research.

Answer: Which are the coactivators of the Yes-associated protein (yap)?


Question: Do you know of anyone who uses the truth to deceive ? When someone tells you something that is true, but leaves out important information that should be included, he can give you a false picture. For example, some might say, "I just won a hundred dollars on the lottery . It was great. I took that dollar ticket back to the store and turned it in for one hundred dollars!" This guy's a winner, right? Maybe, maybe not. We then discover that he bought $200 worth of tickets, and only one was a winner. He's really a big loser! www. .com He didn't say anything that was false, but he left out important information on purpose. That's called a half-truth. Half-truths are not technically lies, but they are just as dishonest. Some politicians often use this trick. Let's say that during Governor Smith's last term, her state lost one million jobs and gained three million jobs. Then she seeked another term. One of her opponents said, "During Governor Smith's term, the state lost one million jobs!" That's true. However, an honest statement would have been, "During Governor Smith's term, the state had a net gain of two million jobs." Advertisers will sometimes use half-truths. It's against the law to make false statements so they try to mislead you with the truth. An advertisement might say, "Nine out of ten doctors advised their patients to take Yucky Pills to cure toothache." It fails to mention that they only asked ten doctors and nine of them work for the Yucky Company. This kind of deception happens too often. Lies are lies, and sometimes the truth can lie as well, which is a sad fact of life.

Answer: How much did the lottery winner lose?


Question: A cell is the smallest structural and functional unit of an organism. Some organisms, like bacteria, consist of only one cell. Big organisms, like humans, consist of trillions of cells. Compare a human to a banana. On the outside, they look very different, but if you look close enough youll see that their cells are actually very similar. Most cells are so small that you cannot see them without the help of a microscope. It was not until 1665 that English scientist Robert Hooke invented a basic light microscope and observed cells for the first time, by looking at a piece of cork. You may use light microscopes in the classroom. You can use a light microscope to see cells ( Figure 1.1). But many structures in the cell are too small to see with a light microscope. So, what do you do if you want to see the tiny structures inside of cells? In the 1950s, scientists developed more powerful microscopes. A light microscope sends a beam of light through a specimen, or the object you are studying. A more powerful microscope, called an electron microscope, passes a beam of electrons through the specimen. Sending electrons through a cell allows us to see its smallest parts, even the parts inside the cell ( Figure 1.2). Without electron microscopes, we would not know what the inside of a cell looked like. The outline of onion cells are visible under a light microscope. In 1858, after using microscopes much better than Hookes first microscope, Rudolf Virchow developed the hypoth- esis that cells only come from other cells. For example, bacteria, which are single-celled organisms, divide in half (after they grow some) to make new bacteria. In the same way, your body makes new cells by dividing the cells you already have. In all cases, cells only come from cells that have existed before. This idea led to the development of one of the most important theories in biology, the cell theory. Cell theory states that: 1. All organisms are composed of cells. 2. Cells are alive and the basic living units of organization in all organisms. 3. All cells come from other cells. As with other scientific theories, many hundreds, if not thousands, of experiments support the cell theory. Since Virchow created the theory, no evidence has ever been identified to contradict it. Although cells share many of the same features and structures, they also can be very different ( Figure 1.3). Each cell in your body is designed for a specific task. In other words, the cells function is partly based on the cells structure. For example: Red blood cells are shaped with a pocket that traps oxygen and brings it to other body cells. Nerve cells are long and stringy in order to form a line of communication with other nerve cells, like a wire. Because of this shape, they can quickly send signals, such as the feeling of touching a hot stove, to your brain. Skin cells are flat and fit tightly together to protect your body. As you can see, cells are shaped in ways that help them do their jobs. Multicellular (many-celled) organisms have many types of specialized cells in their bodies. Red blood cells (left) are specialized to carry oxygen in the blood. Neurons (cen- ter ) are shaped to conduct electrical im- pulses to many other nerve cells. These epidermal cells (right) make up the skin of plants. Note how the cells fit tightly together. While cells are the basic units of an organism, groups of cells can perform a job together. These cells are called specialized because they have a special job. Specialized cells can be organized into tissues. For example, your liver cells are organized into liver tissue. Your liver tissue is further organized into an organ, your liver. Organs are formed from two or more specialized tissues working together to perform a job. All organs, from your heart to your liver, are made up of an organized group of tissues. These organs are part of a larger system, the organ systems. For example, your brain works

Answer:
who developed the idea that all cells come from other cells?