Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Q: Adenomyosis confined to the broad ligament is extremely rare.

A: non-adverse drug event
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Q: We describe two patients in whom painful erosions of their psoriasis developed as the presenting sign of methotrexate toxicity and review the literature, emphasizing the risk factors associated with this manifestation.

A: adverse drug event
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Q: Temozolomide-induced desquamative skin rash in a patient with metastatic melanoma.

A:
adverse drug event
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