Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Empagliflozin is an orally available, potent and highly selective inhibitor of the sodium glucose cotransporter 2 (SGLT2). This study was undertaken to investigate the effect of food on the pharmacokinetics of 25 mg empagliflozin and to assess dose proportionality between 10 mg and 25 mg empagliflozin under fasted conditions. In this open-label, 3-way, cross-over study, 18 healthy volunteers received 3 single doses of empagliflozin in a randomized sequence (25 mg empagliflozin under fasted conditions, 25 mg empagliflozin after a high-fat, high-calorie breakfast and 10 mg empagliflozin under fasted conditions), each separated by a washout period of at least 7 days. Serial plasma samples were collected at selected time points over a period of 72 hours. Administration with food had no clinically relevant effect on the area under the plasma concentration-time curve (AUC0-) of empagliflozin (geometric mean ratio (GMR): 84.04, 90% confidence interval (CI): 80.86 - 87.34). The decrease observed in the maximum plasma concentrations (Cmax) of empagliflozin (GMR: 63.22, 90% CI: 56.74 - 70.44) when administered with food was not considered clinically meaningful. The increases in AUC0- and Cmax for 10 mg vs. 25 mg empagliflozin administered under fasting conditions were roughly dose-proportional, as demonstrated by the slope of the regression lines being slightly less than 1 (slope for AUC0-: 0.94, 95% CI: 0.90 - 0.97; slope for Cmax: 0.91, 95% CI: 0.80 - 1.01). Empagliflozin was well tolerated under fed and fasting conditions. The results support administration of empagliflozin tablets independently of food. Increases in empagliflozin exposure under fasting conditions were roughly dose-proportional between 10 mg and 25 mg empagliflozin.

Answer: Which protein does empagliflozin inhibit?


Question: After tough losses at home, the Raiders traveled to Cleveland to take on the Browns. The Browns scored 9 straight points leading into the 2nd quarter when Billy Cundiff kicked 3 field goals from: 52 (in the 1st quarter), 33, and 26 yards out (in the 2nd quarter) for leads of 3-0, 6-0, and 9-0. The Raiders got on the board when Sebastian Janikowski kicked 2 field goals before halftime from 46 and 38 yards out for a 9-3 and then 9-6 game at halftime. After a scoreless 3rd quarter, the Browns got back to work in the 4th when Brian Hoyer found Andrew Hawkins on a 4-yard touchdown pass for a 16-6 lead followed by Ben Tate running in the end zone for a 5-yard touchdown for a 23-6 game. The Raiders wrapped up the scoring of the game later on when Derek Carr found Andre Holmes 10-yard touchdown pass for the final score: 23-13.

Answer: Which kicker had more total yards, Cundiff or Janikowski?


Question: Focusing on three Anglo-American outbreaks of industrial anthrax, this essay engages the question of how local circumstances influenced the transmission of scientific knowledge in the late nineteenth century. Walpole (Massachusetts), Glasgow, and Bradford (Yorkshire) served as important nodes of transnational investigation into anthrax. Knowledge about the morphology and behavior of Bacillus anthracis changed little while in transit between these nodes, even during complex debates about the nature of bacterial morphology, disease causation, and spontaneous generation. Working independently of their more famous counterparts (Robert Koch and Louis Pasteur), Anglo-American anthrax investigators used visual representations of anthrax bacilli to persuade their peers that a specific, identifiable cause produced all forms of anthrax-malignant pustule (cutaneous anthrax), intestinal anthrax, and woolsorter's disease (pneumonic anthrax). By the late 1870s, this point of view also supported what we would today call an ecological notion of the disease's origins in the interactions of people, animals, and microorganisms in the context of global commerce.

Answer:
What organism causes woolsorter's disease