Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: Ashley and Chris work in the same department designing postcards. Chris had a college degree in art and deeply felt that the degree of his designs was excellent. His last postcard showed the depth of a desert's beauty and delights. "It's just a picture of the desert," Ashley said. "Not deep at all." "Some people desire seeing beauty," Chris replied. "Mine delivers that". Ashley laughed and said, "well, that depends on what you think beauty is." Days later, someone delivered a letter to Ashley. The letter said, "You are worthy of the bad things that will come your way. You will know the taste of defeat, and I will destroy you." Ashley suddenly felt very cold. It was as if the room temperature had dropped 30 degrees. "Who would do such a shocking deed?" she wondered. "I will not let a simple letter defeat me." Just then, Chris came into the room and offered Ashley a piece of his sandwich. "Try some," he smiled widely. "It's delicious." "Are you trying to poison me?" Ashley asked. Chris's answer was delayed from confusion. "What's your problem?" he asked. The next day, Ashley brought a bat to use to defend herself. When Chris saw her bat, he joked, "Defend and win one for the team." Ashley took no notice of him. She spent the whole day reading self-defending books and placed her work on delay. "You can't delay your work. Our job demands us to do our work on time," Chris said. "We must meet the demands of our job." "You're not the boss," Ashley replied. "Don't make demands of me." Because Ashley failed to do her work, she was fired. Chris glanced at Ashley's empty desk and smiled.
[EX A]: What kind of work did Chris and Ashley do?

[EX Q]: Some minerals are very useful. An ore is a rock that contains minerals with useful elements. Aluminum in bauxite ore (Figure 1.1) is extracted from the ground and refined to be used in aluminum foil and many other products. The cost of creating a product from a mineral depends on how abundant the mineral is and how much the extraction and refining processes cost. Environmental damage from these processes is often not figured into a products cost. It is important to use mineral resources wisely. Geologic processes create and concentrate minerals that are valuable natural resources. Geologists study geological formations and then test the physical and chemical properties of soil and rocks to locate possible ores and determine their size and concentration. A mineral deposit will only be mined if it is profitable. A concentration of minerals is only called an ore deposit if it is profitable to mine. There are many ways to mine ores. Aluminum is made from the aluminum- bearing minerals in bauxite. Surface mining allows extraction of ores that are close to Earths surface. Overlying rock is blasted and the rock that contains the valuable minerals is placed in a truck and taken to a refinery. As pictured in Figure 1.2, surface mining includes open-pit mining and mountaintop removal. Other methods of surface mining include strip mining, placer mining, and dredging. Strip mining is like open pit mining but with material removed along a strip. These different forms of surface mining are methods of extracting ores close to Earths surface. Placers are valuable minerals found in stream gravels. Californias nickname, the Golden State, can be traced back to the discovery of placer deposits of gold in 1848. The gold weathered out of hard metamorphic rock in the western Sierra Nevada, which also contains deposits of copper, lead, zinc, silver, chromite, and other valuable minerals. The Underground mining is used to recover ores that are deeper into Earths surface. Miners blast and tunnel into rock to gain access to the ores. How underground mining is approached from above, below, or sideways depends on the placement of the ore body, its depth, the concentration of ore, and the strength of the surrounding rock. Underground mining is very expensive and dangerous. Fresh air and lights must also be brought into the tunnels for the miners, and accidents are far too common. The ores journey to becoming a useable material is only just beginning when the ore leaves the mine (Figure separated out of the ore. A few methods for extracting ore are: heap leaching: the addition of chemicals, such as cyanide or acid, to remove ore. flotation: the addition of a compound that attaches to the valuable mineral and floats. smelting: roasting rock, causing it to segregate into layers so the mineral can be extracted. To extract the metal from the ore, the rock is melted at a temperature greater than 900o C, which requires a lot of energy. Extracting metal from rock is so energy-intensive that if you recycle just 40 aluminum cans, you will save the energy equivalent of one gallon of gasoline.
[EX A]: when valuable minerals are taken from stream gravels, this is called

[EX Q]: Recent evidence suggests that abnormal activation of cyclin-dependent kinase 5 (cdk5) is a critical prodeath signal in stroke. However, the mechanism(s) by which cdk5 promotes death is unclear. Complicating the role of cdk5 are the observations that cdk5 can exist in multiple cellular regions and possess both prosurvival and prodeath characteristics. In particular, the critical role of cytoplasmic or nuclear cdk5 in neuronal jury, in vivo, is unclear. Therefore, we determined where cdk5 was activated in models of ischemia and how manipulation of cdk5 in differing compartments may affect neuronal death. Here, we show a critical function for cytoplasmic cdk5 in both focal and global models of stroke, in vivo. Cdk5 is activated in the cytoplasm and expression of DNcdk5 localized to the cytoplasm is protective. Importantly, we also demonstrate the antioxidant enzyme Prx2 (peroxiredoxin 2) as a critical cytoplasmic target of cdk5. In contrast, the role of cdk5 in the nucleus is context-dependent. Following focal ischemia, nuclear cdk5 is activated and functionally relevant while there is no evidence for such activation following global ischemia. Importantly, myocyte enhancer factor 2D (MEF2D), a previously described nuclear target of cdk5 in vitro, is also phosphorylated by cdk5 following focal ischemia. In addition, MEF2D expression in this paradigm ameliorates death. Together, our results address the critical issue of cdk5 activity compartmentalization, as well as define critical substrates for both cytoplasmic and nuclear cdk5 activity in adult models of stroke.
[EX A]:
What type of enzyme is peroxiredoxin 2 (PRDX2)?