Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
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Question: Following prompt recognition and diagnosis, intravenous thrombolytic therapy was administered 2 hours after symptom onset.

Answer: non-adverse drug event


Question: The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.

Answer: adverse drug event


Question: Unusual pigmentary changes associated with 5-fluorouracil therapy.

Answer:
adverse drug event