In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Ex Input:
The isolation of neutralizing monoclonal antibodies (nmAbs) against the Zika virus (ZIKV) might lead to novel preventative strategies for infections in at-risk individuals, primarily pregnant women. Here we describe the characterization of human mAbs from the plasmablasts of an acutely infected patient. One of the 18 mAbs had the unusual feature of binding to and neutralizing ZIKV despite not appearing to have been diversified by affinity maturation. This mAb neutralized ZIKV (Neut 50~2 μg/ml) but did not react with any of the four dengue virus serotypes. Except for the expected junctional diversity created by the joining of the V-(D)-J genes, there was no deviation from immunoglobulin germline genes. This is a rare example of a human mAb with neutralizing activity in the absence of detectable somatic hypermutation. Importantly, binding of this mAb to ZIKV was specifically inhibited by human plasma from ZIKV-exposed individuals, suggesting that it may be of value in a diagnostic setting.

Ex Output:
A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus


Ex Input:
The novel coronavirus, COVID-19, has sparked an outflow of scientific research seeking to understand the virus, its spread, and best practices in prevention and treatment. If this international research effort is going to be as swift and effective as possible, it will need to rely on a principle of open science. When researchers share data, code, and software and generally make their work as transparent as possible, it allows other researchers to verify and expand upon their work. Furthermore, it allows public officials to make informed decisions. In this study, we analyzed 535 preprint articles related to COVID-19 for eight transparency criteria and recorded study location and funding information. We found that individual researchers have lined up to help during this crisis, quickly tackling important public health questions, often without funding or support from outside organizations. However, most authors could improve their data sharing and scientific reporting practices. The contrast between researchers' commitment to doing important research and their reporting practices reveals underlying weaknesses in the research community's reporting habits, but not necessarily their science.

Ex Output:
Reproducibility and reporting practices in COVID-19 preprint manuscripts


Ex Input:
The mechanism of systemic spread of H5N1 virus in patients with avian influenza is unknown. Here, H5N1 nucleoprotein and hemagglutinin were identified by immunohistochemistry in the nucleus and cytoplasm of neutrophils in the placental blood of a pregnant woman. Viral RNA was detected in neutrophils by in situ hybridization and enhanced realtime polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza. Human avian influenza (H5N1) infection possesses a great potential threat to human health. However, the pathogenesis of this emerging disease is poorly understood. A previous study demonstrated that extrapulmonary organs, including the placenta, trachea, intestine, and brain, can be infected with human avian influenza H5N1 virus [1] . This virus has been detected in serum [2], but the exact means of viral spread beyond the respiratory system is unclear. In the present study, we investigated organs obtained at autopsy from an H5N1 virus-infected pregnant woman and from her fetus in an attempt to study the mechanism of systemic dissemination of H5N1 virus. Neutrophils were abundant in the placenta, and therefore, we evaluated blood cells in the

Ex Output:

Neutrophils May Be a Vehicle for Viral Replication and Dissemination in Human H5N1 Avian Influenza