Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: Three isoforms of human plasma apolipoprotein E (apoE) are ligands to lipoprotein receptors and influence in different manner the synthesis and catabolism of pro-atherogenic triglyceride-rich lipoproteins. Among three isoforms, the apoE4 isoform is associated with increased frequency of atherosclerosis and Alzheimer's disease (AD). The conformational transitions of beta-amyloid (Abeta) influenced by apoE and serum amyloid P (SAP) component are key events in AD development, the accumulation of intermediate diffusible and soluble oligomers of Abeta being of particular significance. SAP and apoE, in a different manner for the three isoforms, serve as "pathological" chaperones during the aggregation of Abeta considered as a conformation-prone process. In turn, apoE consisting of two domains self-associates in solution and intermediate structures differently populated for the three isoforms exist. The different structures of the three isoforms determine their different distribution among various plasma lipoproteins. The structural and metabolic consideration of the common apoE pathway(s) in two pathologies assumes four molecular targets for AD correction: (i) inhibition of the accumulation of diffusible soluble Abeta oligomers; (ii) inhibition of apoE synthesis and secretion by astrocytes, in particular, under lipid-lowering therapy; (iii) inhibition of the binding of apoE and/or SAP to Abeta; (iv) stimulation of the expression of cholesterol transporter ABCA1.

A: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?
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Q: The spin-off movie focuses on Matt Stifler (Tad Hilgenbrinck), the younger brother of Steve Stifler from the previous American Pie films. Matt is eager to enter the family business of making porno films, so he can prove to his older brother that he is "up to the standards of the Stifmeister." Stifler and his friends play a prank on the band students during the seniors' graduation ceremony by spraying pepper spray on the mouthpieces of the band's instruments. Matt narrowly escapes getting caught and stows the can of pepper spray in his front pocket, which subsequently leaks onto his genitals. The band members begin to play "Pomp and Circumstance", only to become too irritated by the pepper spray to continue. During the commotion, one of the students trips and pulls down the back curtain, which reveals Matt, who is washing his pepper-spray-soaked genitals in a drinking fountain, in front of the whole school.The band leader Elyse Houston (Arielle Kebbel) demands that Stifler be punished for ruining their performance, stating that he always gets away with his pranks because he is the school's star football player. The school's guidance counselor Chuck Sherman ("The Sherminator") (played by Chris Owen from the original American Pie films) decides that a worthwhile punishment would be for Stifler to attend band camp, in the hopes that he would make friends with the "bandies" and not follow in the footsteps of his much-hated brother.When first arriving, Matt is very disrespectful to the rules and also everyone at Tall Oaks and gets his band group in trouble. He is sent to the office of Noah Levenstein (Jim's father) (Eugene Levy), who works as the camp MACRO (Morale and Conflict Resolution Officer; he's filling in for Michelle as she is now pregnant), recommends that he try to fit in and earn the band's trust, which is the last thing that Matt wants to do. However, a phone call from a friend, who says that earning their trust will get him better footage for his video, inspires Matt to be much more respectful and humble towards the band.Matt finds out that his dorky roommate Ernie Kapolwitz (Jason Earles) has an extensive knowledge of spy cameras and technology, so Matt agrees to let him help with the filming, making his first friend at Tall Oaks. As Matt "is earning the band's trust" he gets into a big confrontation with their rival band leader, Brandon Van der Camp (Matt Barr), and even goes as far as to accept a duel challenge made by him, having no idea what a "duel" is.It turns out that a duel is the two performers showing off their music skills, with Brandon playing the snare drum, and Matt playing the triangle. Throughout the majority of the competition it seems that Brandon is the heavy favourite; during Brandon's second round of performing, Matt walks away humiliated. As Brandon is about to be declared the official winner, Matt comes back playing the bagpipes to the tune of 'Play That Funky Music' showing that he is actually a decent player, surprising everyone, including Elyse, who is pleasantly surprised by Matt's performance.As Matt is still recording the various happenings at the camp, he gradually becomes friends with some of the band members from his school. He gains some respect from Ernie after Matt sets him up on a date with tattooed bandmate Chloe (Crystle Lightning). Matt starts falling for Elyse, who is revealed to have been a friend of Matt's in 8th grade but had a falling out after Matt started hanging around with Steve and his friends and acting like The Stifmeister. Matt is eventually caught with his movies, and his once-friends want nothing more to do with him.After another talk with Jim's Dad, Matt comes to realize that his brother is not as great or cool as he once thought and that following in his footsteps is not a good idea, so he deletes all the videos he recorded at band camp. He even enlists the help of the band to help Elyse get the band scholarship that Stifler

A: Who is the younger brother of Steve Stifler?
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Q: The Zapruder film is a silent, color motion picture sequence shot by private citizen Abraham Zapruder with a home-movie camera, as U.S. President John F. Kennedy's motorcade passed through Dealey Plaza in Dallas, Texas on November 22, 1963, thereby unexpectedly capturing the President's assassination.

A:
When was Zapruder film in theaters?
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