Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

[Q]: Following prompt recognition and diagnosis, intravenous thrombolytic therapy was administered 2 hours after symptom onset.
[A]: non-adverse drug event


[Q]: This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to be a new entity.
[A]: adverse drug event


[Q]: The aim of this phase I study was to determine the toxicity profile and the optimal dosage of KW-2149.
[A]:
non-adverse drug event