Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

[EX Q]: Question: Does cognitive impairment in patients with multiple sclerosis predict worse caregiver 's health-related quality of life?
Answer: MS patients' caregivers' HRQoL is significantly influenced by information processing speed impairment of MS patients.
[EX A]: yes

[EX Q]: Question: Is the dorsal motor nucleus of the vagus an obligatory trigger site of Parkinson 's disease : a critical analysis of alpha-synuclein staging?
Answer: Our results demonstrate a predominant involvement of the SN and NBM in PD but do not support the existence of a medullary induction site of alpha Syn pathology in all PD brains.
[EX A]: no

[EX Q]: Question: Do mycobacterium tuberculosis secretory proteins downregulate T cell activation by interfering with proximal and downstream T cell signalling events?
Answer: To the best of our knowledge, this is the first study to investigate effect of Ag85A and ESAT-6 on TCR- and TCR/CD28- induced upstream and downstream signalling events of T-cell activation in TB patients. This study showed the effect of secretory antigens of M. tuberculosis in the modulation of T cell signalling pathways. This inflection is accomplished by altering the proximal and distal events of signalling cascade which could be involved in T-cell dysfunctioning during the progression of the disease.
[EX A]:
yes