Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: A common challenge in pathogen discovery by deep sequencing approaches is to recognize viral or subviral pathogens in samples of diseased tissue that share no significant homology with a known pathogen. Here we report a homology-independent approach for discovering viroids, a distinct class of free circular RNA subviral pathogens that encode no protein and are known to infect plants only. Our approach involves analyzing the sequences of the total small RNAs of the infected plants obtained by deep sequencing with a unique computational algorithm, progressive filtering of overlapping small RNAs (PFOR). Viroid infection triggers production of viroid-derived overlapping siRNAs that cover the entire genome with high densities. PFOR retains viroid-specific siRNAs for genome assembly by progressively eliminating nonoverlapping small RNAs and those that overlap but cannot be assembled into a direct repeat RNA, which is synthesized from circular or multimeric repeated-sequence templates during viroid replication. We show that viroids from the two known families are readily identified and their full-length sequences assembled by PFOR from small RNAs sequenced from infected plants. PFOR analysis of a grapevine library further identified a viroid-like circular RNA 375 nt long that shared no significant sequence homology with known molecules and encoded active hammerhead ribozymes in RNAs of both plus and minus polarities, which presumably self-cleave to release monomer from multimeric replicative intermediates. A potential application of the homology-independent approach for viroid discovery in plant and animal species where RNA replication triggers the biogenesis of siRNAs is discussed.
Example Output: Which are the smallest known subviral pathogens of plants?

Example Input: The first year after birth is called infancy. Infancy is a period when the baby grows very fast. During infancy, the baby doubles in length and triples in weight. Other important changes also happen during infancy: The babys teeth start to come in, usually at about six months of age ( Figure 1.1). The baby starts smiling, paying attention to other people, and grabbing toys. The baby begins making babbling sounds. By the end of the first year, the baby is starting to say a few words, such as mama and dada. The baby learns to sit, crawl, and stand. By the end of the first year, the baby may be starting to walk. Childhood begins after the babys first birthday and continues until the teen years. Between one and three years of age, a child is called a toddler. During the toddler stage, growth is still fast, but not as fast as it was during infancy. A toddler learns many new words. The child even starts putting together words in simple sentences. Motor skills also develop quickly during this stage. By age three, most children can run and climb steps. They can hold crayons and scribble with them. They can also feed themselves and use the toilet. From age three until the teens, growth is slower. The body also changes shape. The arms and legs get longer compared to the trunk. Children continue to develop new motor skills. For example, many young children learn how to ride a tricycle and then a bicycle. Most also learn how to play games and sports ( Figure 1.2). By age six, children start losing their baby teeth. Their permanent teeth begin coming in to replace them. They also start school and learn how to read and write. They develop friendships and become less dependent on their parents. There are numerous milestones that occur during the first few years of childhood. These include the use of language, walking and running, understanding simple concepts, pretend play, the development of fine motor skills, the development of independence, Children develop better motor skills as they get older. having temper tantrums, demonstrating separation anxiety, becoming fully potty-trained, showing natural curiosity.
Example Output: during infancy, a baby

Example Input: Isova is a ruined Frankish monastery in the Peloponnese, Greece, which was built after the Fourth Crusade and inhabited by Cistercian monks.
Example Output:
To which religious order did Isova belong?