Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.

Input: Consider Input: The story reports not only the cost of the blood test ($60), but the cost to detect one case (including follow-up), which the researchers calculated to be $28,600. This is excellent context. The story would have been better if it had noted that the people included in this study were at unusually high risk for developing this cancer. The 34 cases found after screening 20,000 people is almost 200 times the typical annual rate in the US and other countries (less than 1 per 100,000 people per year). The ultimate measure of cost is cost-effectiveness (cost per life-year saved) which requires survival data. These analyses can also be adjusted for quality of life. While most of this story is careful to note that this test has yet to show clinical effectiveness, that caution is trampled by the claim that this blood test “boosted patients’ chances of survival,” something that this type of study cannot determine. The claim that this test is more accurate than existing methods is also premature, since the study did not directly compare the blood test to existing methods. Finding more early-stage cancers is a necessary but hardly sufficient step in the pathway of demonstrating benefit for a new screening test. Clinical trials are needed to address issues of false positives, over diagnosis, over treatment, and survival. The story reports that developers of this blood test still need to show low rates of false positive or negative results. A low false negative rate means there are fewer missed cases of serious disease. The trade-off, though, is a higher false positive rate. All positive tests will need to be evaluated with a gold standard diagnostic test and the safety, acceptability, and costs of that gold standard test will profoundly affect the uptake of the new screening test. While the story reports that this study was a “proof-of-concept” experiment, it then says the test boosted survival, something that can only be known after directly comparing the new test to existing methods. Making treatment “dramatically more effective” can be proven only with randomized trials. All screening tests that can detect cancers at an earlier stage will be associated with an apparent increase in survival time, but as explained in more detail below, this does not necessarily mean that patients with screen-detected cancers actually live longer than they would have otherwise. Efficacy can be established only with an RCT. The story could have done a better job pointing out the many limitations in the work. For example, there was no follow-up testing for people who had negative blood test results. Even though the researchers surveyed participants a year after the testing, they didn’t produce any data on how many of the people with negative blood tests actually had cancer. What’s more, the researchers compared the survival rates of their patients to a different group of cancer patients from another study, which raises questions about how comparable the groups really are. There was also no discussion of the possibility that at least some of the tumors discovered through this screening might not have developed into dangerous cancers. The story does not address lead-time bias (that longer survival might be at least partly due to finding the tumor earlier in its natural course, rather than to just the effect of treatment). The researchers noted that the effect of lead time bias can only really be known through a randomized, controlled trial. We will rate the story satisfactory on this criterion because it is careful to note that this test is not ready for clinical use and that the study results apply to only one type of cancer. However, the story would have been better if it had pointed out just how rare this cancer is, less than one case per 100,000 people in the US per year. That is about 3,000 cases in the US per year — out of about 1.7 million cancers diagnosed annually. And the comment that the cancer “is prevalent” in southern China and Southeast Asia may be misleading. While it may occur more often in the region, rates are still on the order of 10 to 20 per 100,000 which is hardly widespread. The story squeaks by on this criterion because it includes a quote from an editorial in the journal that was written by an independent source. It would have been more useful to readers to include more comment and context from someone without financial ties to this study. The story is upfront about the financial interests of the researchers themselves and the company that owns the rights to their work, noting the keen interest in bringing this test to market. Although the story reports that “that nasopharyngeal carcinoma typically goes undetected until later on, when patients report symptoms such as recurring nosebleeds,” it does not tell readers anything about how often these cancers are found at an early stage. Readers are not given a sense of how patients typically fare with existing methods of diagnosis. The story clearly reports that the test is still experimental and that developers have yet to show that it could be practical and effective in clinical practice. The story highlights the desire for a new blood test that could be clinically useful. The story doesn’t appear to rely on a news release. It includes quotes from a telephone interview with an executive at the company developing this test.

Output: Silicon Valley Startup Grail Sees Hope for Cancer Blood Test


Input: Consider Input: Knox County’s proposed ordinance hasn’t been drafted yet, but County Attorney Yvette Kirchoff said the ordinance wouldn’t be retroactive so homeowners won’t have to remove existing plants. If the measure is approved, Knox County would be the first in Indiana to move forward with such an ordinance, Kirchoff told the Vincennes Sun-Commercial . Invasive species can take over and alter environments, said Will Drews, a natural resource specialist with the Knox County Soil and Water Conservation District. They can also disrupt pasture lands and agriculture. “We’ve introduced most of them, unfortunately, over time,” he said. “They’re mostly from other parts of the world, such as Europe or Asia, and the problem is that they have no natural predators, so they just kind of get out of control.” One major issue is that some invasive species — such as wintercreeper, Japanese honeysuckle and burning bush — can be found in local nurseries and are used by landscapers, Drews said. “These are plants that are literally destroying our forests,” Drews said. “That’s frustrating to a lot of the folks that I work with and those who are aware of the problem.” The state Department of Natural Resources and state lawmakers have been working on legislation that would attempt to regulate the spread of invasive species, but the process has been slow, Drews said. Drews and Kirchoff are drafting the ordinance and will present it to the county commissioners soon. ___ Information from: Vincennes Sun-Commercial, http://www.vincennes.com

Output: Indiana county working on invasive plants ordinance.


Input: Consider Input: Congo had been due on Sunday to mark an end to the second-deadliest outbreak of the virus on record, until a case was confirmed on Friday in the eastern city of Beni. The outbreak has killed more than 2,200 people since August 2018 in an area of the country where militia violence hobbled efforts to contain it. The latest victim was an 11-month-old girl, who was treated at the same health centre as the previous case, a 26-year-old electrician, said Boubacar Diallo, deputy incident manager for the WHO’s Ebola response. Officials say it is not yet clear how the electrician contracted Ebola. He had no known contacts with other Ebola patients and was not a survivor of the virus who could have relapsed, the government said on Friday. Flare-ups or one-off transmissions are common towards the end of Ebola outbreaks, and a new case does not necessarily mean that the virus will spread out of control again. Ebola causes fever, bleeding, vomiting and diarrhoea and spreads among humans through bodily fluids. During this outbreak it killed about two thirds of those it infected. The WHO has identified 215 people who came into contact with the electrician, including 53 health workers at three facilities the man visited before he died, Diallo said. All but one of the health workers had already been vaccinated, he said. Two new vaccines have helped contain the virus, though public mistrust and militia attacks prevented health workers from reaching some hard-hit areas. On Saturday, a group of angry young men threw stones at a team of WHO workers and Beni’s deputy mayor as they attempted to decontaminate the electrician’s home and trace his contacts, Diallo said. “For them Ebola is over,” he told Reuters. “People here have some problems understanding how this case just came two days before the declaration of the end,” Diallo said. The deputy mayor was forced to abandon his car and escape by motorbike taxi, said Kambale Sabuni, head of the police in Beni.


Output: Congo records second Ebola death in days: WHO.