Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy. We enrolled 457 patients who had active rheumatoid arthritis despite long-term methotrexate therapy in a 6-month, double-blind, placebo-controlled trial. The primary outcome was the American College of Rheumatology (ACR) 20 response (which indicates at least a 20% reduction in the number of both tender and swollen joints and improvement in at least three of five other criteria) at month 6. R788, at a dose of 100 mg twice daily and at a dose of 150 mg once daily, was significantly superior to placebo at month 6 (ACR 20 response rates of 67% and 57%, respectively, vs. 35%; P<0.001 for the comparison of both doses with placebo). It was also significantly superior with respect to ACR 50, which indicates at least a 50% improvement (43% and 32% vs. 19%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.007 for the comparison of the 150-mg dose with placebo) and ACR 70 (28% and 14% vs. 10%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.34 for the comparison of the 150-mg dose with placebo). A clinically significant effect was noted by the end of the first week of treatment. Adverse effects included diarrhea (in 19% of subjects taking the 100-mg dose of R788 vs. 3% of those taking placebo), upper respiratory infections (14% vs. 7%), and neutropenia (6% vs. 1%). R788 was associated with an increase in systolic blood pressure of approximately 3 mm Hg between baseline and month 1, as compared with a decrease of 2 mm Hg with placebo; 23% of the patients taking R788 vs. 7% of the patients receiving placebo required the initiation of or a change in antihypertensive therapy. In this phase 2 study, a Syk inhibitor reduced disease activity in patients with rheumatoid arthritis; adverse events included diarrhea, hypertension, and neutropenia. Additional studies will be needed to further assess the safety and efficacy of Syk-inhibition therapy in patients with rheumatoid arthritis. (Funded by Rigel; ClinicalTrials.gov number, NCT00665925.) 
 Question: Which enzyme is inhibited by a drug fostamatinib?
spleen tyrosine kinase

Context: Finally, in 2001, SV Nord-Nordstern and SC Wedding-Rapide came together to form SV Nord Wedding 1893. 
 Question: What year did SV Nord Wedding 1893 dissolve?
2001

Context: The Caste War of Yucatan was a conflict that lasted from 1847 to 1901. It began with the revolt of native Maya people led by Maya chiefs Jacinto Pat and Cecilio Chi, against the population of European descent called "Yucatecos", who had political and economic control. A lengthy war ensued between the Yucateco forces in the north-west of the Yucatan and the independent Maya in the south-east. It officially ended with the occupation of the Maya capital of Chan Santa Cruz by the Mexican army in 1901, although skirmishes with villages and small settlements that refused to acknowledge Mexican control continued for over another decade. Adam Jones wrote: "This ferocious race war featured genocidal atrocities on both sides, with up to 200,000 killed." Because of the conflict, on November 24, 1902, Yucatan had a second territorial division when Porfirio Diaz decreed the creation of the Federal Territory of Quintana Roo, with capital in the port of Payo Obispo . In little more than half a century, Yucatan lost more than two thirds of its original territory. 
 Question: What happened first, the revolt of native Maya people, or the occupation of Chan Santa Cruz?

revolt of native maya people