In this task, you are given a sentence. You are expected to recognize the name of gene or protein. Although there might be several correct answers, you need to write one of them.
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Question:  Since RIP140 generally down - regulates receptor activity in mammalian cells and specifically down - regulates coactivation mediated by SRC - 1 , we propose a model in which RIP140 indirectly regulates nuclear receptor AF - 2 activity by competition for coactivators such as SRC - 1 .

Answer: SRC - 1


Question:  The encoded 260 - amino - acid ( aa ) ( H1 - I ) and 240 - aa ( H1 - II ) polypeptides possess the typical tripartite organization of animal H1 histones , with variable N - and C - terminal domains flanking a conserved ' globular ' DNA - binding domain .

Answer: animal H1 histones


Question:  These observations demonstrate that KSR is capable of uncoupling the MAP kinase activation from its target phosphorylation , and thus provide a novel mechanism for modulating the Ras - MAP kinase signaling pathway .

Answer:
MAP kinase