In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Q: Paragraph: Immaturity of the neonatal immune system is causative for high morbidity in calves and colostrum intake is crucial for acquiring passive immunity. Pathogenesis is promoted by reactive oxygen species accumulating at birth if counter-regulation is inadequate. The flavonol quercetin exerts antioxidative and anti-inflammatory effects that may enhance neonatal health. The aim of this work was to study effects of quercetin feeding on metabolic, antioxidative and inflammatory parameters in neonatal calves to investigate whether quercetin could compensate for insufficient colostrum supply. Twenty-eight newborn calves were assigned to two dietary groups fed colostrum or milk-based formula on day 1 and 2 and milk replacer thereafter. From day 2 onwards, 7 calves per diet group were additionally fed quercetin aglycone (50 mg/(kg body weight × day)). Blood samples were taken repeatedly to measure plasma concentrations of flavonols, glucose, lactate, total protein, albumin, urea, non-esterified fatty acids, triglycerides, cholesterol, insulin, glucagon, cortisol, immunoglobulins, fibrinogen, haptoglobin and serum amyloid A. Trolox equivalent antioxidative capacity, ferric reducing ability of plasma, thiobarbituric acid reactive species and F2isoprostanes were analyzed to evaluate plasma antioxidative status. Expression of tumor necrosis factor, interleukin-1α, interleukin-1β, serum amyloid A, haptoglobin, fibrinogen, Creactive protein, catalase, glutathione peroxidase and superoxide dismutase mRNA were measured in liver tissue on day 8. Plasma flavonol concentrations were detectable only after quercetin-feeding without differences between colostrum and formula feeding. Plasma glucose, lactate, total protein, immunoglobulins, triglycerides, cholesterol, trolox equivalent antioxidative capacity and thiobarbituric acid reactive species were higher after colostrum feeding. Body temperature, fecal fluidity and plasma concentrations of cortisol and PLOS ONE | Competing Interests: The authors have declared that no competing interests exist. haptoglobin were higher in formula-than in colostrum-fed groups. Hepatic mRNA expression of tumor necrosis factor was higher after quercetin feeding and expression of C-reactive protein was higher after formula feeding. Data confirm that colostrum improves neonatal health and indicate that quercetin feeding cannot compensate for insufficient colostrum supply. Quercetin Supplementation in Neonatal Calves with Respect to Different Diet PLOS ONE | 
 Title: Quercetin Feeding in Newborn Dairy Calves Cannot Compensate Colostrum Deprivation: Study on Metabolic, Antioxidative and Inflammatory Traits

A: True
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Q: Paragraph: Nurses are the largest group of healthcare providers and are often the first line responders to a disaster event. Nurses' disaster competence, motivation for disaster engagement, and factors that impact their motivation to respond to disaster events need to be understood. The purposes of the study were to determine the predictive relationships between Taiwanese nurses' disaster competence, anticipatory disaster stress, and motivation for disaster engagement. A cross-sectional design was used to analyze data collected between August 2017 and December 2017 from eight hospitals in southern Taiwan. Ninety participants who met the recruitment criteria completed and returned questionnaires with an 88.24% response rate. Data collection involved administering the Disaster Nursing Competence Questionnaire, Anticipatory Disaster Stress Questionnaire, and the Motivation of Disaster Engagement Questionnaire. The results indicated that anticipatory disaster stress was positively correlated with disaster competence and motivation for disaster engagement. Disaster competence and willingness to join a hospital disaster rescue predicts an individuals' motivation for disaster engagement. The results of the study add to the understanding of factors that correlate with nurses' motivation to participate in disaster events. By understanding these factors, the government and healthcare administrators can design disaster education plans and other strategies to improve Taiwanese nurses' motivation to engage in disaster events. 
 Title: 101545 and Technology

A: True
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Q: Paragraph: IAV and the host Crm1-dependent nuclear export machinery requires further exploration. Recently, Chase and collaborators showed that the interaction between vRNPs and the nuclear export machinery takes place in dense chromatin domains that allow IAV to "snatch" Crm1-RanGTP nuclear export complexes to the detriment of cellular substrates 13 . These results, together with other observations, highlight the involvement of host nuclear compartmentalization and chromatin territories in regulating nuclear traffic of IAV vRNPs [14] [15] [16] [17] . Several investigations, including ours, have revealed that IAV induce a strong remodeling of nuclear architecture with marked modifications of the nucleoli ultrastructure and compartments 3,17-20 . The nucleolus, known as the site of ribosome biogenesis, is also a sensor of cellular stresses and is involved in several cellular pathways, such as cell-cycle regulation or apoptosis 21-23 . Several DNA and RNA viruses, including cytoplasmic viruses are known to induce nucleolar alterations that contribute towards optimal infection 24-26 . In the context of IAV, their interplay with nucleolus and selective interactions with several nucleolar components appears to be decisive in the outcome of infection 17, 20 . Ozawa and colleagues demonstrated that dynamic nucleolar localization of NP is functionally significant by contributing to efficient viral replication and transcription 27 . Moreover, different studies have demonstrated a subtype dependent interaction between viral non-structural protein (NS1) and cellular nucleolin, suggesting a role of the nucleolar targeting functions of NS1 in IAV pathogenesis 28, 29 . Proteomics-based approaches have revealed changes in the nucleolar proteome of IAV infected cells 5,30 and identified several nucleolar components, such as nucleolin, nucleophosmin (B23) and ribosomal proteins, as putative interactants of reconstituted IAV vRNPs 7 . In addition, high-throughput RNAi approaches have highlighted the functional requirement of several of these nucleolar components in viral replication 31-33 . Nucleolin is a multifunctional protein that contributes extensively to DNA and RNA regulatory mechanisms, including ribosome biogenesis, chromatin remodeling, mRNA stability and translation, nuclear export of RNA and protein complexes, and microRNA processing 34, 35 . In this way, nucleolin takes part in several cellular functions, such as gene silencing, senescence, cell proliferation and growth 23,35-37 , and continuously shuttles between nucleolar/nuclear compartments and the cytoplasm up to the cell surface 38,39 . Moreover, through its ability to associate with diverse target RNAs, nucleolin is implicated in various pathological processes, particularly cancer and viral infection 40 . In this context, different functional interactions with nucleolin have been described for several DNA viruses, such as poliovirus 41 , adenovirus 42 , HSV 43, 44 or CMV 45, 46 , and several RNA viruses, such as hepatitis C and delta viruses 47,48 , coronavirus 49 , hPIV-3 50 , papillomavirus HPV9 51 , Crimean-Congo hemorrhagic fever virus 52 , HIV1 53 , noroviruses 54 and notably the infectious salmon anemia virus (ISAV) which belongs to the family Orthomyxoviridae, as IAV 55 . Altogether, these studies highlight nucleolin as a key interacting factor that is crucial, in some cases, for viral replication and involved in nucleo-cytoplasmic export of viral genome or viral egress 44 . At first, we observed the dynamic redistribution of nucleolin from a nucleolar to a very specific nuclear polarized pattern during infection. The aim of this study was therefore to investigate the functional relationship between IAV and nucleolin with regards to the nuclear traffic of vRNPs and their targeting to the dense chromatin compartment 13 and in the context of the viral remodeling of the host nuclear architectures 17,20 . We first characterized NP, the main component of IAV vRNP, as co-localizing and interacting with endogenous nucleolin during infection. Moreover, using cell fractionation and RNAi approaches, we suggest that nucleolin contributes to efficient vRNP trafficking and viral replication. Based on our results, we propose nucleolin as an essential host factor for the chromatin targeting of the nucleocytoplasmic export complex of vRNPs during infection. 
 Title: Nucleolin interacts with influenza A nucleoprotein and contributes to viral ribonucleoprotein complexes nuclear trafficking and efficient influenza viral replication OPEN

A:
False
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