In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

[Q]: Even though coronavirus infection of humans is not normally associated with severe diseases, the identification of the coronavirus responsible for the outbreak of severe acute respiratory syndrome showed that highly pathogenic coronaviruses can enter the human population. Shortly thereafter, in Holland in 2004, another novel human coronavirus (HCoV-NL63) was isolated from a seven-month old infant suffering from respiratory symptoms. This virus has subsequently been identified in various countries, indicating a worldwide distribution. HCoV-NL63 has been shown to infect mainly children and the immunocommpromised, who presented with either mild upper respiratory symptoms (cough, fever and rhinorrhoea) or more serious lower respiratory tract involvement such as bronchiolitis and croup, which was observed mainly in younger children. In fact, HCoV-NL63 is the aetiological agent for up to 10% of all respiratory diseases. This review summarizes recent findings of human coronavirus HCoV-NL63 infections, including isolation and identification, phylogeny and taxonomy, genome structure and transcriptional regulation, transmission and pathogenesis, and detection and diagnosis.
[A]: Understanding Human Coronavirus HCoV-NL63


[Q]: Infection of BALB/c mice with mouse hepatitis virus, strain JHM (MHV-JHM), at any of several intervals relative to ovalbumin (OVA) administration resulted in elevated OVA-specific IgG 2 a titers. Since gamma interferon (IFN) has been implicated as an up-regulator of IgG 2 a production, attempts were made to determine whether levels of this cytokine were modified in sera of infected mice. Serum IFN-y was not detected, but treatment of MHV-JHMinfected mice with monoclonal anti-IFN-? antibody resulted in high mortality with decreased survival times, enhanced virus titers in liver and spleen, and more severe virus-associated pathology, compared to mock-treated, infected mice. Immunotherapy with recombinant IFN-7 ameliorated disease as reflected by mortality rates and virus titers in target organs.
[A]: The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM


[Q]: In many systems transfer between the endoplasmic reticulum and the Golgi apparatus is blocked at temperatures below 16°C. In virus-infected cells in culture, a special membrane compartment is seen to accumulate. Our studies with rat liver show a similar response to temperature both in situ with slices and in vitro with isolated transitional endoplasmie reticulum fractions. With isolated transitional endoplasmic reticulum fractions, when incubated in the presence of nucleoside tripbosphate and a cytosol fraction, temperature dependent formation of vesicles occurred with a Ql0 of "2 but was apparent only at temperatures greater than 12°C. A similar response was seen in situ at 12°C and 16°C where fusion of transition vesicles with cis Golgi apparatus, but not their formation, was blocked and transition vesicles accumulated in large numbers. At 18°C and below and especially at 8°C and 12°C, the cells responded by accumulating smooth tubular transitional membranes near the cis Golgi apparatus face. With cells and tissue slices at 20°C neither transition vesicles nor the smooth tubular elements accumulated. Those transition vesicles which formed at 3"/°C were of a greater diameter than those formed at 4°C both in situ and in vitro. The findings show parallel responses between the temperature dependency of transition vesicle formation in vitro and in situ and suggest that a subP0Pulation of the transitional endoplasmic reticulum may be morphologically and functionally homologous to the 16°C compartment observed in vitally-infected cell lines grown at low temperatures. transition vesicle --endoplasmie reticulum --temperature --rat liver
[A]:
Identification of the 16°C compartment of the endoplasmic reticulum in rat liver and cultured hamster kidney cells