In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Input: Consider Input: Question: Enzymatic regulation by phosphorylation: 
 Options:  <1> It is reversible. <2> It requires enzymes that directly introduce the Pi. <3> Introduce the Pi into acidic and basic amino acids. <4> Always activate enzymes. <5> It is carried out by phosphatases.

Output: 1


Input: Consider Input: Question: Under the name of xanthines are grouped: 
 Options:  <1> The coca leaf, cocaine and crack. <2> Methadone and heroin <3> The MDA and the MDMA. <4> Nicotine and inhalants. <5> Caffeine and theophylline.

Output: 5


Input: Consider Input: Question: The reaction conditions for the preparation of 2-methyl-1-methoxypropan-2-ol from 2,2-dimethyloxirane are: 
 Options:  <1> The reaction with methanol in an acid medium. <2> There is no effective synthetic route. <3> The reaction with methylmagnesium bromide and subsequent hydrolysis. <4> The reaction with sodium methoxide in methanol. <5> The reaction with triphenylphosphine.


Output: 4