Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: On 1 January 2013, Saint-Germain-sur-l'Arbresle and Nuelles merged becoming one commune called Saint-Germain-Nuelles.

Output: What was replaced Saint-Germain-sur-l'Arbresle?


Input: Consider Input: The Spiritual Exercises of Ignatius of Loyola (Latin original: Exercitia spiritualia) (composed 1522--1524) are a set of Christian meditations, prayers and mental exercises, written by Saint Ignatius of Loyola, a 16th-century Spanish priest, theologian, and founder of the Society of Jesus (Jesuits).

Output: What group was Spiritual Exercises of Ignatius of Loyola a member of?


Input: Consider Input: During active transport, molecules move from an area of low concentration to an area of high concentration. This is the opposite of diffusion, and these molecules are said to flow against their concentration gradient. Active transport is called "active" because this type of transport requires energy to move molecules. ATP is the most common source of energy for active transport. As molecules are moving against their concentration gradients, active transport cannot occur without assistance. A carrier protein is always required in this process. Like facilitated diffusion, a protein in the membrane carries the molecules across the membrane, except this protein moves the molecules from a low concentration to a high concentration. These proteins are often called "pumps" because they use energy to pump the molecules across the membrane. There are many cells in your body that use pumps to move molecules. For example, your nerve cells (neurons) would not send messages to your brain unless you had protein pumps moving molecules by active transport. The sodium-potassium pump ( Figure 1.1) is an example of an active transport pump. The sodium-potassium pump uses ATP to move three sodium (Na+ ) ions and two potassium (K+ ) ions to where they are already highly concentrated. Sodium ions move out of the cell, and potassium ions move into the cell. How do these ions then return to their original positions? As the ions now can flow down their concentration gradients, facilitated diffusion returns the ions to their original positions either inside or outside the cell.


Output: complete the following sentence. as molecules are moving against their concentration gradients, active transport cannot occur without __________.