TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Three isoforms of human plasma apolipoprotein E (apoE) are ligands to lipoprotein receptors and influence in different manner the synthesis and catabolism of pro-atherogenic triglyceride-rich lipoproteins. Among three isoforms, the apoE4 isoform is associated with increased frequency of atherosclerosis and Alzheimer's disease (AD). The conformational transitions of beta-amyloid (Abeta) influenced by apoE and serum amyloid P (SAP) component are key events in AD development, the accumulation of intermediate diffusible and soluble oligomers of Abeta being of particular significance. SAP and apoE, in a different manner for the three isoforms, serve as "pathological" chaperones during the aggregation of Abeta considered as a conformation-prone process. In turn, apoE consisting of two domains self-associates in solution and intermediate structures differently populated for the three isoforms exist. The different structures of the three isoforms determine their different distribution among various plasma lipoproteins. The structural and metabolic consideration of the common apoE pathway(s) in two pathologies assumes four molecular targets for AD correction: (i) inhibition of the accumulation of diffusible soluble Abeta oligomers; (ii) inhibition of apoE synthesis and secretion by astrocytes, in particular, under lipid-lowering therapy; (iii) inhibition of the binding of apoE and/or SAP to Abeta; (iv) stimulation of the expression of cholesterol transporter ABCA1.

SOLUTION: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?

PROBLEM: The deflated Giants traveled to Minnesota to take on the Vikings. Already eliminated from the playoffs due to Washington beating Philadelphia the night before to secure the NFC East for the first time since 2012, they were without their star wide receiver Odell Beckham Jr. as he was suspended for his actions in a Week 15 loss against Carolina. The Vikings stingy defense put pressure on Eli Manning all game, forcing Tom Coughlin to bench Manning after three interceptions. The Giants defense was not a factor as they failed to contain the Vikings rushing attack all game long. Linebacker JT Thomas was ejected from the game in the 4th quarter for throwing a punch. The loss of Beckham was too steep to overcome and the Giants wound up losing 49-17, dropping to 6-9.

SOLUTION: Which team won the game?

PROBLEM: We have dreams almost every night. Do you ever notice the colors of your dreams? Do you dream in black and white or do you dream in yellow, red and green? New research suggests that the type of television you watched as a child has a great effect on the color of your dreams. While almost all people under 25 dream in color, thousands of people over 55, all of whom were brought up with black and white TV sets, often dream in monochrome . "It suggests there could be a critical period in our childhood when watching films has a big impact on the way dreams are formed", said Eva Murzyn, a psychology student at Dundee University in Britain who carried out the study. Research from 1915 through the 1950s suggested that the vast majority of dreams are in black and white. But the tide turned in the sixties, and later results suggested that up to 83 percent of dreams contain some color. Since this period also marked the transition between black-and-white film and TV and Technicolor ,an obvious explanation was that the media had been painting people's dreams. However, there weren't any firm conclusions. But now Miss Murzyn believes she has proven the link. She made a survey of more than 60 people, half of whom were over 55 and half of whom were under 25. She asked the volunteers to answer a questionnaire on the color of their dreams and their childhood exposure to film and TV. She then analyzed her own data. Only 4.4 percent of the under-25s' dreams were black and white. The over-55s who had had access to color TV and film during their childhood also reported a very low proportion of just 7.3 percent. But the over-55s who only had access to black-and -white media reported dreaming in black and white about a quarter of the time. Even though they would have spent only a few hours a day watching TV or films, their attention and emotion would have been heightened during this time, leaving a deeper imprint on their mind, Miss Murzyn told the New Scientist. "The crucial time is between three and ten when we all begin to have the ability to dream", she said.

SOLUTION:
In which magazine can you find the article?