Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

[Q]: Paragraph: The trial results on patients with a gene anomaly known as NTRK fusion, which occurs in less than 1 percent across a range of tumor types, were presented at the annual congress of the European Society for Medical Oncology (ESMO) in Munich on Sunday. Germany’s Bayer and U.S. partner Loxo, in turn, released data for their rival compound larotrectinib, which slightly improved on previous high-efficacy readings in an enlarged trial. Traditionally, oncologists have made treatment decisions based on where in the body a tumor started, increasingly helped by the growing knowledge of cancer’s complex genetic drivers. Under the tumor-agnostic approach, also known as pan-tumor, drugmakers skip the organ-of-origin perspective and regroup patients based only on signature genetic mutations, but success in real life will depend on the fast spread of comprehensive gene-sequencing tools for tissue samples. Individually, the mutations are so rare that cancer units are seen as unlikely to run dedicated tests for each. Roche’s Foundation Medicine supplies the comprehensive kits, competing with Thermo Fisher Scientific and Caris Life Sciences. “It’s one of the reasons we acquired Foundation Medicine, to make this comprehensive genomic profiling routine and upfront in the course of the disease,” said Daniel O’Day, the head of Roche’s Pharmaceuticals division. Loxo’s larotrectinib pill, co-developed with Bayer, was last year shown to shrink tumors in 75 percent of patients with the NTRK fusion gene anomaly, occurring in the lung, pancreas, or more than a dozen other organs. On Sunday, the response rate to larotrectinib within an enlarged group of 122 trial participants - up from 55 initially and now spanning 24 tumor types - was shown to be 81 percent. Roche said the readings from the two NTRK fusion trials were not comparable because they are made up of different patient types. Loxo’s study, for instance, included some cancers in children, while Roche plans to investigate those separately. The Roche compound is designed to tackle several oncogenic mutations and last month, it unveiled data here on entrectinib pushing back tumors in 77 percent of lung cancer patients with a mutation called ROS1. Merck & Co’s Keytruda in May last year became the first drug to win approval for pan-tumor use, though that remains a relatively small market for the mega-selling drug. Bayer and Loxo are testing a second pan-tumor drug, LOXO-195. Roche Pharmaceutical’s O’Day welcomed a wider field. “Both things have to happen: You need genomic profiling and you need enough targeted medicines to encourage physicians to make that diagnosis upfront very complete. This is the world we’re entering,” he said. Though response rates could encourage a race for more such drugs, the need for suitable gene mutations or fusions will be a tall order, said oncologist Ulrik Lassen of Copenhagen’s Rigshospitalet, who co-authored the larotrectinib study. “You need to screen a lot of patients to find the needle in the haystack and the method is complicated, costly and time-consuming. When we get better at using these technologies, we can find more oncogenic fusions and companies will be smart enough to find the agents that target them.”  Roche acquired entrectinib as part of its takeover deal with U.S. cancer drug specialist Ignyta Inc for $1.7 billion, agreed in December last year. Immuno-oncology remains another major business area for Roche, which also released positive results on using its Tecentriq drug in a group of breast cancer patients with a particularly poor prognosis. Claim: Roche takes on Loxo, Bayer in gene-defined cancer class.
[A]: Roche’s entrectinib cancer pill was shown to shrink tumors in 57 percent of patients within a group that can only be identified via genetic profiling, as the Swiss drugmaker challenges an alliance of Bayer and Loxo Oncology in a new targeted treatment area.


[Q]: Paragraph: "Raising backyard chickens has been satisfying some foodies’ affection for the uber-local egg and lower-fat meat in urban areas, including metro Atlanta, for about a decade. Now the Centers for Disease Control is warning of a downside to the popular trend: salmonella outbreaks traced to some backyard owners kissing and cuddling their flocks. The CDC findings drew some media attention last month, and a PolitiFact reader who heard the health alert on NPR’s ""Morning Edition"" on July 16 asked us to dig deeper. We went directly to the source, the CDC, which is headquartered in Atlanta and has been investigating four recent Salmonella outbreaks that, as of July 29, had infected 218 people in 41 states. Five of them were in Georgia, 19 were in Alabama, 5 were in North Carolina, 11 were in South Carolina and 6 were in Tennessee. Fifty of the 218 people have required hospitalization for Salmonella, the major symptoms of which are usually diarrhea, fever and abdominal pain. No deaths have been reported, CDC spokeswoman Kristen Nordlund said. So how exactly do CDC officials know that some of these cases are due to backyard breeders kissing and cuddling live poultry? Dr. Megin Nichols, a veterinarian with the CDC, told PolitiFact the agency has been tracking upward trends in both the number of outbreaks and people infected in the past five years and has been working to trace their causes. ""We’ve been trying to interview these people to find out how they are getting sick,"" Nichols said. ""We are finding a certain proportion that are due to very close contact -- something that surprised us here at the CDC."" Salmonella is a germ that lives naturally in the intestine of chickens, ducks and many other animals. It doesn’t typically make the birds sick, but they can transmit the germs in their droppings and on their feet, feathers and beaks, even when they look clean and healthy, the CDC says. The germs also can get on their cages, coops, feed, water dishes, hay, plants and the area where they live and roam. In addition, the bacteria can rest on the hands, shoes and clothes of those who work around the birds or play with them. And Nichols told us that among the people who became ill between 2008 and 2014 due to baby poultry exposure, 49 percent, or 196 out of 400, reported snuggling and holding baby birds. Another 13 percent, or about 53, reported kissing baby birds, she said. Those people, many of whom were young children, became sick through fecal oral contact, Nichols said. Those same interviews also showed that about 46 percent of backyard breeders are keeping live poultry in their homes, she said. Epidemiologic, laboratory, and traceback findings have linked the most recent four outbreaks of human Salmonella infections to contact with chicks, ducklings, and other live poultry from multiple hatcheries. Interviews have been conducted with 140 of those who were recently ill and, 117, or 84 percent, reported contact with live poultry in the week before their illness began, according to the CDC website. Additional interviews to determine whether that contact included snuggling and kissing have yet to be conducted, Nichols said. An increasing number of people around the country are choosing to keep live poultry - mostly chickens, ducks, turkeys and geese as part of a greener, healthier lifestyle. Local governments, including several in metro Atlanta, have changed their zoning ordinances in recent years to accommodate the trend, and groups of backyard poultry buffs meet regularly in the region to talk chicken. Backyard owners have told reporters at The Atlanta Journal-Constitution that the benefits include fresh eggs and meat, a built-in source of fertilizer for their gardens and ready-made bug-killers. Some say they give their chickens names, the freedom to roam the house and yard and cuddle and coddle them like family pets. The larger problem According to the CDC, salmonella, named for an American scientist who discovered the bacteria, is estimated to cause a million illnesses in the United States a year, with 19,000 hospitalizations and 380 deaths. Most people develop diarrhea and the other conditions within 12 to 72 hour after infection and recover without treatment in four to seven days. It has the potential to turn deadly if it spreads from the intestines to the bloodstream, and then to other body sites. Prompt treatment with antibiotics is critical, and the elderly, infants, and people with impaired immune systems are more likely to have a severe illness. In the largest recent outbreak, which occurred between March 2013 and July 2014, more than 600 people in 29 states and Puerto Rico were infected with seven outbreak strains. The outbreak was associated with one brand of chicken, which led to a company recall of more than 40,000 pounds of chicken products, according to the CDC. To prevent salmonella infections related to backyard farming, the CDC’s Nichols encourages several common-sense rules. These include thorough handwashing after contact with the chicken, keeping live poultry out of the home, and avoiding snuggling, close contact with the birds’ beaks or other close exposure that would allow ingestion of bacteria. She will be one of the experts featured in a webinar on the topic of practicing backyard bird biosecurity at 7p.m. Thursday. Our conclusion The CDC has issued a warning against kissing or snuggling backyard chickens. It follows four recent Salmonella outbreaks that, as of July 29, had infected 218 people in 41 states. Five of them were in Georgia. Interviews have been conducted with 140 of the ill and 117, or 84 percent, reported contact with live poultry in the week before their illness began, according to the CDC website. The CDC also has evidence from outbreaks between 2008 to 2014. In that period, they found that of the people who became infected with salmonella due to baby poultry exposure, 49 percent, or 196 out of 400 people, reported snuggling and holding baby birds. Another 13 percent, or about 53, reported kissing baby birds.. That’s cause to sound the alarm." Claim: Caution: Kissing and cuddling chickens can be hazardous to your health.
[A]: CDC: Kissing and cuddling backyard chickens linked to salmonella infections


[Q]: Paragraph: They found several creams caused skin cancer in the specially bred mice, which had been pre-treated with ultraviolet radiation. The cancers are not melanoma, the deadliest kind of skin cancer, they stressed in their report in the Journal of Investigative Dermatology, but another type called squamous cell carcinoma. Such tumours are slow growing, highly treatable and only fatal if patients fail to have them removed. Allan Conney and colleagues at Rutgers University in New Jersey said they discovered the risk while testing a theory that caffeine could prevent skin cancer. “We sort of got into this by accident,” Conney said in a telephone interview. “We wanted a safe cream that we could put the caffeine into.”   They were testing specially bred albino mice, which are prone to develop skin cancer. The mice are pre-treated with ultraviolet radiation to simulate the effects of a human who has had heavy sun exposure in the past but then stopped — something that may be happening in the population as people realize the risks of getting a tan. Conney’s team decided to test the creams first and found that all four they tested caused tumours to grow on the mice. He said he does not know why, but suspects two ingredients — mineral oil and sodium laurel sulphate. “We’d like to understand the mechanism. What is most important is to see whether these moisturizing creams are tumorigenic in people,” Conney said. He said his lab is not equipped to do this but someone should. But he added, “I don’t think that people should be scared because this is a mouse study and we don’t know whether or not it applies to humans.”   Other experts were sceptical about the study. “This is a pretty artificial situation with the mouse skin primed by a lot of UV light to develop cancer,” Karol Sikora, Medical Director of Cancer Partners U.K. in Britain, said in a statement. Dr. Jonathan Rees, an expert in dermatology at the University of Edinburgh in Scotland, said squamous cell carcinoma was not a big health worry. “Non-melanoma skin cancer in man is very, very common and is almost 100 percent curable with an operation usually simpler than a tooth filling,” Rees said in a statement. Conney said the mouse was a commonly used model in skin cancer but said he agreed that it does not perfectly replicate human skin and human behaviour. He said his team approached Johnson & Johnson to create a cream without the suspect products and they developed one using other readily available ingredients. “They are things that are commonly used in many moisturizing creams,” he said. This cream did not cause the tumours in the mice, they said. He said Rutgers and Johnson & Johnson had patented the new cream jointly but did not know whether it would be commercially developed. A spokesman at the company was not immediately available for comment. Claim: Skin creams seen to cause tumours on mice.
[A]:
Certain commonly available skin creams may cause skin tumours, at least in mice, and experts should be checking to see if they might cause growths in people as well, researchers reported on Thursday.