Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: Siltuximab, a chimeric monoclonal antibody with high affinity and specificity for interleukin-6, has been shown to enhance anti-multiple myeloma activity of bortezomib and corticosteroid in vitro. We evaluated the safety, pharmacokinetics, immunogenicity, and antitumor effect of siltuximab in combination with bortezomib and dexamethasone in Japanese patients with relapsed or refractory multiple myeloma. This open-label, phase 1, dose-escalating study used two doses of siltuximab: 5.5 and 11.0 mg/kg (administered on day 1 of each 21-day cycle). In total, nine patients were treated. The most common grade 3/4 adverse events, lymphopenia (89 %) and thrombocytopenia (44 %), occurred in patients receiving both doses of siltuximab; however, no dose-limiting toxicities (DLTs) were observed. Following intravenous administration of siltuximab at 5.5 and 11.0 mg/kg, the maximum serum concentration and the area under the curve from 0 to 21 days and from 0 to infinity increased in an approximately dose-proportional manner. Mean half-life, total systemic clearance, and volume of distribution were similar at doses of 5.5 and 11.0 mg/kg. Across both doses, six of the nine patients had complete or partial response (22 and 44 %, respectively). In conclusion, as no DLT was observed, the recommended dose for this combination is 11.0 mg/kg once every 3 weeks. The study is registered at [Link] as NCT01309412.
Example Output: Which interleukin is blocked by Siltuximab?

Example Input: Mowat-Wilson syndrome is a genetic condition characterized by a recognizable facial phenotype in addition to moderate to severe cognitive disability with severe speech impairment and variable multiple congenital anomalies. The anomalies may include Hirschsprung disease, heart defects, structural eye anomalies including microphthalmia, agenesis of the corpus callosum, and urogenital anomalies. Microcephaly, seizure disorder and constipation are common. All typical cases result from haploinsufficiency of the ZEB2 (also known as ZFHX1B or SIP-1) gene, with over 100 distinct mutations now described. Approximately 80% of patients have a nonsense or frameshift mutation detectable by sequencing, with the rest having gross deletions necessitating a dosage sensitive assay. Here we report on the results of comprehensive molecular testing for 27 patients testing positive for MWS. Twenty-one patients had a nonsense, frameshift, or splice site mutation identified by sequencing; 14 of which localized to exon 8 and 17 of which are novel. Six patients had deletions in the ZEB2 gene, including two novel partial gene deletions. This report, the first such analysis in North American patients, adds to the growing list of both novel pathogenic mutations associated with MWS, as well as other variants in the ZEB2 gene. In addition, we suggest an economical testing strategy.
Example Output: Which gene is responsible for the development of the Mowat-Wilson syndrome?

Example Input: In nuclear fusion, two or more small nuclei combine to form a single, larger nucleus. You can see an example in the Figure 1.1. In this example, nuclei of two hydrogen isotopes (tritium and deuterium) fuse to form a helium nucleus. A neutron and a tremendous amount of energy are also released. Nuclear fusion of hydrogen to form helium occurs naturally in the sun and other stars. It takes place only at extremely high temperatures. Thats because a great deal of energy is needed to overcome the force of repulsion between the positively charged nuclei. The suns energy comes from fusion in its core, shown in the Figure 1.2. In the core, temperatures reach millions of degrees Kelvin. Click image to the left or use the URL below. URL: The Sun Q: Why doesnt nuclear fusion occur naturally on Earth? A: Nuclear fusion doesnt occur naturally on Earth because it requires temperatures far higher than Earth tempera- tures. Scientists are searching for ways to create controlled nuclear fusion reactions on Earth. Their goal is develop nuclear fusion power plants, where the energy from fusion of hydrogen nuclei can be converted to electricity. You can see how this might work in the Figure 1.3. In the thermonuclear reactor, radiation from fusion is used to heat water and produce steam. The steam can then be used to turn a turbine and generate electricity. The use of nuclear fusion for energy has several pros. Unlike nuclear fission, which involves dangerous radioactive elements, nuclear fusion involves just hydrogen and helium. These elements are harmless. Hydrogen is also very plentiful. There is a huge amount of hydrogen in ocean water. The hydrogen in just a gallon of water could produce as much energy by nuclear fusion as burning 1,140 liters (300 gallons) of gasoline! The hydrogen in the oceans would generate enough energy to supply all the worlds people for a very long time. Unfortunately, using energy from nuclear fusion is far from a reality. Scientists are a long way from developing the necessary technology. One problem is raising temperatures high enough for fusion to take place. Another problem is that matter this hot exists only in the plasma state. There are no known materials that can contain plasma, although a magnet might be able to do it. Thats because plasma consists of ions and responds to magnetism. Click image to the left or use the URL below. URL:
Example Output:
nuclear fusion occurs inside