Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

Smaller size of ring will a summer drought cause in a tree.
What size of ring will a summer drought cause in a tree?

Interstitial fluid are all hormones secreted into before entering the circulatory system.
Where are all hormones secreted into before entering the circulatory system?

Downregulation helps cells reduce their reaction to excessive hormone levels.

What helps cells reduce their reaction to excessive hormone levels?