Given scientific fact as input, generate the question from this fact such that it can be answered from the input.
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Question: How much is involved in the reaction does the coefficient in front of an element in a formula indicate.

Answer: What does the coefficient in front of an element in a formula indicate?


Question: Multiple genes mutations is usually necessary to develop cancer.

Answer: What is usually necessary to develop cancer?


Question: Yeast fermentation causes holes in bread.

Answer:
What causes holes in bread?