Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Input: Consider Input: BACKGROUND: Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy.

Output: adverse drug event


Input: Consider Input: However, other factors or drugs (e.g. cresol) are thought to induce MH.

Output: adverse drug event


Input: Consider Input: Both infants continued on medical therapy until they reached 1 month of age.


Output: non-adverse drug event