Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein tau. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds tau with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the tau-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10(-9) M MAP2c and 10(-8) M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and tau might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease.

A: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?
****
Q: There are records of fingerprints taken many centuries ago. The ancient Babylonians pressed the tips of their fingerprints into clay to record business trade. The Chinese used ink-on-paper finger impressions for business. However, fingerprinting wasn't used as a method for identifying criminals until the 19th century. In 1858, Sir William Herschel was working as an official of the Hooghly district in Jungipoor, India.In order to reduce fraud , he had people living in the district record their fingerprints when signing business documents. A few years later, Scottish doctor Henry Faulds was working in Japan when he discovered fingerprints left by artists on ancient pieces of clay.This finding inspired him to begin investigating fingerprints.In 1880, Faulds wrote to his cousin, the famous naturalist Charles Darwin, and asked for help with developing a fingerprint classification system.Darwin refused, but sent the letter to his cousin, Sir Francis Gallon, who was an eugenicist . Gallon began collecting fingerprints and eventually gathered some 8, 000 different samples to analyze. In 1892, he published a book called "Fingerprints", in which he outlined a fingerprint classification system--the first existence. Around the same time, Juan Vucetich, a police officer in Buenos Aires, Argentina, was developing his own version of a fingerprinting system.In 1892, Vucetich was called in to assist with the investigation of the two boys murdered in Necoche, a village near Buenos Aires. Their mother, Francisca Rojas, accused a neighbour named Velasquez. But when Vucetich compared the fingerprints found at the murder scene to those of both Velasquez and Rojas, _ matched Rojas' exactly.She admitted her crime. This was the first time fingerprints had been used in a criminal investigation.Vucetich called his system comparative dactyloscopy . It's still used in many Spanish-speaking countries. Sir Edward Henry, in charge of the Metropolitan Police of London, soon became interested in using fingerprints to catch criminals. In 1896, he added to Gallon's technique, creating his own classification system, the Henry Classification System. It is the primary method of fingerprint classification throughout most of the world.

A: Who first came up with the idea of creating a fingerprint classification system?
****
Q: Cellular respiration is the process of extracting energy in the form of ATP from the glucose in the food you eat. How does cellular respiration happen inside of the cell? Cellular respiration is a three step process. Briefly: 1. In stage one, glucose is broken down in the cytoplasm of the cell in a process called glycolysis. 2. In stage two, the pyruvate molecules are transported into the mitochondria. The mitochondria are the organelles known as the energy "powerhouses" of the cells (Figure 1.1). In the mitochondria, the pyruvate, which have been converted into a 2-carbon molecule, enter the Krebs cycle. Notice that mitochondria have an inner membrane with many folds, called cristae. These cristae greatly increase the membrane surface area where many of the cellular respiration reactions take place. 3. In stage three, the energy in the energy carriers enters an electron transport chain. During this step, this energy is used to produce ATP. Oxygen is needed to help the process of turning glucose into ATP. The initial step releases just two molecules of ATP for each glucose. The later steps release much more ATP. Most of the reactions of cellular respira- tion are carried out in the mitochondria. What goes into the cell? Oxygen and glucose are both reactants of cellular respiration. Oxygen enters the body when an organism breathes. Glucose enters the body when an organism eats. What does the cell produce? The products of cellular respiration are carbon dioxide and water. Carbon dioxide is transported from your mitochondria out of your cell, to your red blood cells, and back to your lungs to be exhaled. ATP is generated in the process. When one molecule of glucose is broken down, it can be converted to a net total of 36 or 38 molecules of ATP. This only occurs in the presence of oxygen. The overall chemical reaction for cellular respiration is one molecule of glucose (C6 H12 O6 ) and six molecules of oxygen (O2 ) yields six molecules of carbon dioxide (CO2 ) and six molecules of water (H2 O). Using chemical symbols the equation is represented as follows: C6 H12 O6 + 6O2 6CO2 + 6H2 O ATP is generated during the process. Though this equation may not seem that complicated, cellular respiration is a series of chemical reactions divided into three stages: glycolysis, the Krebs cycle, and the electron transport chain. Stage one of cellular respiration is glycolysis. Glycolysis is the splitting, or lysis of glucose. Glycolysis converts the 6-carbon glucose into two 3-carbon pyruvate molecules. This process occurs in the cytoplasm of the cell, and it occurs in the presence or absence of oxygen. During glycolysis a small amount of NADH is made as are four ATP. Two ATP are used during this process, leaving a net gain of two ATP from glycolysis. The NADH temporarily holds energy, which will be used in stage three. In the presence of oxygen, under aerobic conditions, pyruvate enters the mitochondria to proceed into the Krebs cycle. The second stage of cellular respiration is the transfer of the energy in pyruvate, which is the energy initially in glucose, into two energy carriers, NADH and FADH2 . A small amount of ATP is also made during this process. This process occurs in a continuous cycle, named after its discover, Hans Krebs. The Krebs cycle uses a 2-carbon molecule (acetyl-CoA) derived from pyruvate and produces carbon dioxide. Stage three of cellular respiration is the use of NADH and FADH2 to generate ATP. This occurs in two parts. First, the NADH and FADH2 enter an electron transport chain, where their energy is used to pump, by active transport, protons (H+ ) into the intermembrane space of mitochondria. This establishes a proton gradient across the inner membrane. These protons then flow down their concentration gradient, moving back into the matrix by facilitated diffusion. During this process, ATP is made by adding inorganic phosphate to ADP. Most of the ATP produced during cellular respiration is made during this stage. For each glucose that starts cellular respiration, in the presence of oxygen (aerobic conditions), 36-38 ATP are generated. Without oxygen, under

A:
how is atp made during the electron transport chain?
****