Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Input: Consider Input: Coagulation parameters of 3 different time-points were assessed and compared: before administration of any blood product (time-point 1), before administration of the first dose of rFVIIa (time-point 2), and 4 hours after the administration of the last dose of rFVIIa (time-point 3).

Output: non-adverse drug event


Input: Consider Input: Possible relationships between the white matter lesions and extrinsic toxic agents are discussed.

Output: non-adverse drug event


Input: Consider Input: Further study revealed that all three patients had low plasma renin activity and nonsuppresible plasma aldosterone levels after saline infusion.


Output: non-adverse drug event