Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: The Linth (pronounced (lnt) ''lint'') is a Swiss river that rises near the village of Linthal in the mountains of the canton of Glarus, and eventually flows into the Obersee section of Lake Zurich.

A: What river does Linth turn into?
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Q: The Rebellion was the career highlight for both leaders; Cumberland resigned from the Army in 1757 and died of a stroke in 1765. Charles was initially treated as a hero on his return to Paris but the Stuarts were once again barred from France by the 1748 Treaty of Aix-la-Chapelle. Henry Stuart's entry into the Catholic Church in June 1747 was seen as tacit acceptance the Jacobites were finished and Charles never forgave him. He continued attempts to reignite the cause, including a secret visit to London in 1750 but habitual heavy drinking made him argumentative and hard to work with. In 1759, he met French Chief Minister de Choiseul to discuss another invasion attempt but Choiseul dismissed him as incapable through drink. When his father James died in 1766, Pope Clement XIII refused to recognise him as Charles III, despite the strong objections of his brother Henry. Charles never visited Britain again and died in Rome in January 1788, a disappointed and embittered man.

A: Which happened first, Charles secret visit to London or his meeting with French Chief Minister de Choiseul?
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Q: The ubiquitously expressed iron storage protein ferritin plays a central role in maintaining cellular iron homeostasis. Cytosolic ferritins are composed of heavy (H) and light (L) subunits that co-assemble into a hollow spherical shell with an internal cavity where iron is stored. The ferroxidase activity of the ferritin H chain is critical to store iron in its Fe3+ oxidation state, while the L chain shows iron nucleation properties. We describe a unique case of a 23-yr-old female patient affected by a homozygous loss of function mutation in the L-ferritin gene, idiopathic generalized seizures, and atypical restless leg syndrome (RLS). We show that L chain ferritin is undetectable in primary fibroblasts from the patient, and thus ferritin consists only of H chains. Increased iron incorporation into the FtH homopolymer leads to reduced cellular iron availability, diminished levels of cytosolic catalase, SOD1 protein levels, enhanced ROS production and higher levels of oxidized proteins. Importantly, key phenotypic features observed in fibroblasts are also mirrored in reprogrammed neurons from the patient's fibroblasts. Our results demonstrate for the first time the pathophysiological consequences of L-ferritin deficiency in a human and help to define the concept for a new disease entity hallmarked by idiopathic generalized seizure and atypical RLS.

A:
Which deficiency is the cause of restless leg syndrome?
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