In this task, you're given a passage, further information available on a particular linked term from the statement, and an answer term. Your job is to generate a question that can use the information provided to obtain the given answer. You should use the information on both passage and link information to create the question. Note that the answer to the question should be exactly the given answer, and if the answer is none, the answer to the question shouldn't be obtainable from the passage or linked information.

[EX Q]: Passage: Adam also co-wrote and co-starred in the movie Rats and Cats, which premiered to sell-out audiences and critical acclaim at the 2006 Melbourne International Film Festival and went on to screen at the SXSW Film Festival in 2009. From 2006 to 2010, he was head writer on the AFI Awards screened on the Nine Network, working alongside hosts Geoffrey Rush and Stephen Curry. Zwar's other acting credits include playing Martin Gero in Series 1 of 2 of the Network Ten crime drama Rush, as well as the SBS series Carla Cametti PD, the ABC television movie Valentine's Day, the crime drama Underbelly for Channel Nine. In 2016, Zwar joined the main cast of Foxtel's drama Top of the Lake.
 Link Information: none Answer: none
[EX A]: Who else co-starred in the movie that Zwar co-wrote that premiered to sell-out audiences at the 2006 Melbourne International Film Festival?

[EX Q]: Passage: The construction of the cathedral was approved in 1894 by the Ministry of Internal Affairs under Tsarist Russia. Groundbreaking was in 1899; construction work began in 1901 and was completed ten years later. Three-aisled and built from red brick, the cathedral is based on a design by architect Tomasz Bohdanowicz-Dworzecki. The style was influenced by Westminster Abbey and Milan Cathedral. With the help of funds from Catholic parishes in Russia and its neighbouring states, the church was consecrated as a chapel for Moscow's Polish parish in 1911. In the aftermath of the Russian Revolution in 1917, the Provisional Government was overthrown by the Bolsheviks and Russia eventually became part of the Soviet Union in 1922. Because the promotion of state atheism was a part of Marxist–Leninist ideology, the government ordered many churches closed; the cathedral was closed in 1938. During World War II, it was threatened with demolition, and was used after the war for civil purposes, as a warehouse and then a hostel. Following the fall of communism in 1991, it returned to being a church in 1996. In 2002 it was elevated to the status of cathedral. Following an extensive and costly programme of reconstruction and refurbishment, the cathedral was reconsecrated in 2005.
 Link Information: none Answer: none
[EX A]: Who was the ruler of the Russian Empire when the construction of the Cathedral of the Immaculate Conception was approved?

[EX Q]: Passage: AGRP has been demonstrated to be an inverse agonist of melanocortin receptors, to be specific MC3-R and MC4-R. The melanocortin receptors, MC3-R and MC4-R, are directly linked to metabolism and body weight control. These receptors are activated by the peptide hormone α-MSH (melanocyte-stimulating hormone) and antagonized by the agouti-related protein. Whereas α-MSH acts broadly on most members of the MCR family (with the exception of MC2-R), AGRP is highly specific for only MC3-R and MC4-R. This inverse agonism not only antagonizes the action of melanocortin agonists such as α-MSH but also further decreases the cAMP produced by the affected cells. The exact mechanism by which AgRP inhibits melanocortin-receptor signalling is not completely clear. It has been suggested that Agouti-related protein binds MSH receptors and acts as a competitive antagonist of ligand binding. Studies of Agouti protein in B16 melanoma cells supported this logic. The expression of AgRP in the adrenal gland is regulated by glucocorticoids. The protein blocks α-MSH-induced secretion of corticosterone.
 Link Information: Melanocortin receptor 3 is a protein that in humans is encoded by the MC3R gene. Answer: Melanocortin receptor 3 is a protein that in humans is encoded by the MC3R gene.


[EX A]:
What is the difference between the two melanocortin receptors?