Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: Specific outcomes upon activation of the c-Jun N-terminal kinase (JNK) pathway critically depend on the intensity and duration of signal transmission. Dual-specificity phosphatases (DUSPs) play a very important role in these events by modulating the extent of JNK phosphorylation and activation and thus regulating cellular responses to stress. M3/6 (DUSP8) is one of the dual-specificity protein phosphatases with distinct specificity towards JNK. It has been shown that M3/6 itself is phosphorylated by JNK upon stimulation with arsenite, but the role of this phosphorylation has not been investigated. In this study, we mapped JNK-induced phosphorylation sites on M3/6 using mass spectrometry. Phosphorylated residues Ser 515, Thr 518 and Ser 520 were identified and site-directed mutagenesis was employed to investigate their role. Upon arsenite stimulation, M3/6 mutated at these sites exhibited decreased phosphorylation compared to the wild-type protein. No difference was observed in terms of the enzyme's in vitro phosphatase activity, its substrate specificity towards JNK isoforms, its interactions with JNK and the scaffold family of JNK-interacting proteins (JIPs), its stability or its subcellular localization. Interestingly, expression of M3/6 phosphorylation mutants delayed the time-course of JNK phosphorylation and activation by arsenite. We propose that phosphorylation of the M3/6 phosphatase by JNK in response to stress stimuli results in attenuation of phosphatase activity and acceleration of JNK activation.
Example Output: Which protein is affected by dusp8 activation?

Example Input: Anemone (born 9 August 1950) is a French actress, filmmaker and political activist.
Example Output: What is the native tongue of Anémone?

Example Input: Singapore's selection as the host of the 28th Southeast Asian Games of 2015 was announced in 2011 during the 26th Southeast Asian Games, held in Indonesian cities Palembang and Jakarta. Singapore had previously been nominated to host the event in 2007 and 2013, but turned down both opportunities citing costs associated with the construction of the new Singapore Sports Hub.
Example Output:
What happened first: 26th Southeast Asian Games or 28th Southeast Asian Games?