TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: There are records of fingerprints taken many centuries ago. The ancient Babylonians pressed the tips of their fingerprints into clay to record business trade. The Chinese used ink-on-paper finger impressions for business. However, fingerprinting wasn't used as a method for identifying criminals until the 19th century. In 1858, Sir William Herschel was working as an official of the Hooghly district in Jungipoor, India.In order to reduce fraud , he had people living in the district record their fingerprints when signing business documents. A few years later, Scottish doctor Henry Faulds was working in Japan when he discovered fingerprints left by artists on ancient pieces of clay.This finding inspired him to begin investigating fingerprints.In 1880, Faulds wrote to his cousin, the famous naturalist Charles Darwin, and asked for help with developing a fingerprint classification system.Darwin refused, but sent the letter to his cousin, Sir Francis Gallon, who was an eugenicist . Gallon began collecting fingerprints and eventually gathered some 8, 000 different samples to analyze. In 1892, he published a book called "Fingerprints", in which he outlined a fingerprint classification system--the first existence. Around the same time, Juan Vucetich, a police officer in Buenos Aires, Argentina, was developing his own version of a fingerprinting system.In 1892, Vucetich was called in to assist with the investigation of the two boys murdered in Necoche, a village near Buenos Aires. Their mother, Francisca Rojas, accused a neighbour named Velasquez. But when Vucetich compared the fingerprints found at the murder scene to those of both Velasquez and Rojas, _ matched Rojas' exactly.She admitted her crime. This was the first time fingerprints had been used in a criminal investigation.Vucetich called his system comparative dactyloscopy . It's still used in many Spanish-speaking countries. Sir Edward Henry, in charge of the Metropolitan Police of London, soon became interested in using fingerprints to catch criminals. In 1896, he added to Gallon's technique, creating his own classification system, the Henry Classification System. It is the primary method of fingerprint classification throughout most of the world.

SOLUTION: Who first came up with the idea of creating a fingerprint classification system?

PROBLEM: Our previous work has shown that gene knockout of the sodium-glucose cotransporter SGLT2 modestly lowered blood glucose in streptozotocin-diabetic mice (BG; from 470 to 300 mg/dl) and prevented glomerular hyperfiltration but did not attenuate albuminuria or renal growth and inflammation. Here we determined effects of the SGLT2 inhibitor empagliflozin (300 mg/kg of diet for 15 wk; corresponding to 60-80 mgkg(-1)day(-1)) in type 1 diabetic Akita mice that, opposite to streptozotocin-diabetes, upregulate renal SGLT2 expression. Akita diabetes, empagliflozin, and Akita + empagliflozin similarly increased renal membrane SGLT2 expression (by 38-56%) and reduced the expression of SGLT1 (by 33-37%) vs. vehicle-treated wild-type controls (WT). The diabetes-induced changes in SGLT2/SGLT1 protein expression are expected to enhance the BG-lowering potential of SGLT2 inhibition, and empagliflozin strongly lowered BG in Akita (means of 187-237 vs. 517-535 mg/dl in vehicle group; 100-140 mg/dl in WT). Empagliflozin modestly reduced GFR in WT (250 vs. 306 l/min) and completely prevented the diabetes-induced increase in glomerular filtration rate (GFR) (255 vs. 397 l/min). Empagliflozin attenuated increases in kidney weight and urinary albumin/creatinine ratio in Akita in proportion to hyperglycemia. Empagliflozin did not increase urinary glucose/creatinine ratios in Akita, indicating the reduction in filtered glucose balanced the inhibition of glucose reabsorption. Empagliflozin attenuated/prevented the increase in systolic blood pressure, glomerular size, and molecular markers of kidney growth, inflammation, and gluconeogenesis in Akita. We propose that SGLT2 inhibition can lower GFR independent of reducing BG (consistent with the tubular hypothesis of diabetic glomerular hyperfiltration), while attenuation of albuminuria, kidney growth, and inflammation in the early diabetic kidney may mostly be secondary to lower BG.

SOLUTION: Which protein does empagliflozin inhibit?

PROBLEM: An old man was fishing by a river. A child was watching him. The old man was really good at fishing and it didn't take him much time to catch a basket of fish. The old man saw that the child was very cute, and he wanted to give her a whole basket of fish. But the child shook her head. The old man was surprised and asked "Why don't you want the fish?" The child replied,"I want the fishing rod in your hands." The old man asked, "Why do you want the rod?" "It won't take long to eat all the fish in the basket. But if I have the fishing rod, I can go fishing by myself and I won't be afraid of not having any fish to eat." I think you will certainly say that the girl is very smart. Wrong! If she doesn't know how to fish, she cannot have fish to eat, even though she has the fishing rod. It's useless to only have a fishing rod. Fishing skills are the most important, not the fishing rod. Too many people think that if they have a "fishing rod" in their life, they will no longer fear the difficulties in life. They are just like the child, who thought that if she had a fishing rod, she would have fish to eat.

SOLUTION:
Where did the old man put the fish?