Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: MicroRNAs (miRNAs) constitute a large family of noncoding RNAs that function as guide molecules in diverse gene silencing pathways. Current efforts are focused on the regulatory function of miRNAs, while little is known about how these unusual genes themselves are regulated. Here we present the first direct evidence that miRNA genes are transcribed by RNA polymerase II (pol II). The primary miRNA transcripts (pri-miRNAs) contain cap structures as well as poly(A) tails, which are the unique properties of class II gene transcripts. The treatment of human cells with alpha-amanitin decreased the level of pri-miRNAs at a concentration that selectively inhibits pol II activity. Furthermore, chromatin immunoprecipitation analyses show that pol II is physically associated with a miRNA promoter. We also describe, for the first time, the detailed structure of a miRNA gene by determining the promoter and the terminator of mir-23a approximately 27a approximately 24-2. These data indicate that pol II is the main, if not the only, RNA polymerase for miRNA gene transcription. Our study offers a basis for understanding the structure and regulation of miRNA genes.
[EX A]: Which polymerase transcribes pri-miRNAs?

[EX Q]: Jonas Valanciunas (Lithuanian pronunciation: (jons vntuns); born 6 May 1992) is a Lithuanian professional basketball player for the Toronto Raptors of the National Basketball Association (NBA).
[EX A]: What team is Jonas Valančiūnas on?

[EX Q]: In previous concepts, you learned about B and T cells, special types of white blood cells that help your body to fight off a specific pathogen. They are necessary when the body is fighting off an infection. But what happens to them after the pathogen has been destroyed? Most B and T cells die after an infection has been brought under control. But some of them survive for many years. They may even survive for a persons lifetime. These long-lasting B and T cells are called memory cells. They allow the immune system to remember the pathogen after the infection is over. If the pathogen invades the body again, the memory cells will start dividing in order to fight the pathogen or disease. These dividing cells will quickly produce a new army of B or T cells to fight the pathogen. They will begin a faster, stronger attack than the first time the pathogen invaded the body. As a result, the immune system will be able to destroy the pathogen before it can cause an infection. Being able to attack the pathogen in this way is called immunity. Immunity can also be caused by vaccination. Vaccination is the process of exposing a person to a pathogen on purpose in order to develop immunity. In vaccination, a modified pathogen is usually injected under the skin by a shot. Only part of the pathogen is injected, or a weak or dead pathogen is used. It sounds dangerous, but the shot prepares your body for fighting the pathogen without causing the actual illness. Vaccination triggers an immune response against the injected antigen. The body prepares "memory" cells for use at a later time, in case the antigen is ever encountered again. Essentially, a vaccine imitates an infection, triggering an immune response, without making a person sick. In many countries, children receive their first vaccination at birth with the Hepatitis B shot, which protects infants from Hepatitis B, a serious liver disease. Before vaccines, many children died from diseases that vaccines now prevent, such as whooping cough, measles, and polio. Those same germs exist today, but because babies are now protected by vaccines, we do not see these diseases nearly as often. Diseases you have probably been vaccinated against include measles, mumps, and chicken pox. How does a vaccine work? See How a Vaccine Works at and The History of Vaccines at . Click image to the left or use the URL below. URL:
[EX A]:
what is the first vaccination for many children?