In this task, you are given a question and a context passage. You have to answer the question based on the given passage.

[Q]: Who were the Spanish monarchs that financed Christopher Columbus?, Context: The 1469 marriage of Isabella I of Castile and Ferdinand II of Aragon and the 1479 death of John II of Aragon led to the creation of modern-day Spain. In 1492, Granada was captured from the Moors, thereby completing the Reconquista. Portugal had during the 15th century – particularly under Henry the Navigator – gradually explored the coast of Africa, and in 1498, Vasco da Gama found the sea route to India. The Spanish monarchs met the Portuguese challenge by financing the expedition of Christopher Columbus to find a western sea route to India, leading to the discovery of the Americas in 1492.
[A]: Isabella I of Castile and Ferdinand II of Aragon


[Q]: Who, between Phillip Jackson and Vincent Harris, did NOT design the Gurkha Monument?, Context: The headquarters of the MoD are in Whitehall and are now known as Main Building. This structure is neoclassical in style and was originally built between 1938 and 1959 to designs by Vincent Harris to house the Air Ministry and the Board of Trade. The northern entrance in Horse Guards Avenue is flanked by two monumental statues, Earth and Water, by Charles Wheeler. Opposite stands the Gurkha Monument, sculpted by Philip Jackson and unveiled in 1997 by Queen Elizabeth II. Within it is the Victoria Cross and George Cross Memorial, and nearby are memorials to the Fleet Air Arm and RAF (to its east, facing the riverside). A major refurbishment of the building was completed under a PFI contract by Skanska in 2004.
[A]: Vincent Harris


[Q]: What can be caused when an antibiotic target is absent from a baterial genome?, Context: Several molecular mechanisms of antibacterial resistance exist. Intrinsic antibacterial resistance may be part of the genetic makeup of bacterial strains. For example, an antibiotic target may be absent from the bacterial genome. Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA. Antibacterial-producing bacteria have evolved resistance mechanisms that have been shown to be similar to, and may have been transferred to, antibacterial-resistant strains. The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange. For instance, antibacterial resistance genes can be exchanged between different bacterial strains or species via plasmids that carry these resistance genes. Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials. Cross-resistance to several antibacterials may also occur when a resistance mechanism encoded by a single gene conveys resistance to more than one antibacterial compound.
[A]:
Intrinsic antibacterial resistance