In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Q: Paragraph: Very limited evidence has been reported on host T cell responses to the pandemic H1N1 swine-origin influenza A virus (S-OIV) infection in humans. Therefore, we investigated the proportions of peripheral T cell subsets and analyzed the relationship of T helper subset changes with T cell activation during this infection. We found that these S-OIV-infected patients exhibited rapid lymphopenia, T cell activation and preferential loss of Th17 subset at the early stage of acute infection. Statistical analysis indicated that CD4 depletion and loss of Th17 cells, rather than Th1 or Treg cells, were correlated with CD4 T cell activation. More importantly, upregulated IFN-α likely contributed to the functional loss of Th17 cells. Thus, rapidly generalized lymphopenia, preferential loss of Th17 population and T cell activation presented as characteristics of the early immune response in S-OIV-infected patients. These findings, therefore, may be helpful for an earlier diagnosis and further studies of immune pathogenesis of S-OIV infection. 
 Title: Preferential loss of Th17 cells is associated with CD4 T cell activation in patients with 2009 pandemic H1N1 swine-origin influenza A infection

A: True
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Q: Paragraph: Background 3 In silico bacterial, viral, and human truth datasets were generated to evaluate available metagenomics 4 algorithms. Sequenced datasets include background organisms, creating ambiguity in the true 5 source organism for each read. Bacterial and viral datasets were created with even and staggered 6 coverage to evaluate organism identification, read mapping, and gene identification capabilities of 7 available algorithms. These truth datasets are provided as a resource for the development and 8 refinement of metagenomic algorithms. Algorithm performance on these truth datasets can inform 9 decision makers on strengths and weaknesses of available algorithms and how the results may be best 10 leveraged for bacterial and viral organism identification and characterization. 11 12 Source organisms were selected to mirror communities described in the Human Microbiome Project as 13 well as the emerging pathogens listed by the National Institute of Allergy and Infectious Diseases. The 14 six in silico datasets were used to evaluate the performance of six leading metagenomics algorithms: 15 MetaScope, Kraken, LMAT, MetaPhlAn, MetaCV, and MetaPhyler. 16 Results Algorithms were evaluated on runtime, true positive organisms identified to the genus and species 19 levels, false positive organisms identified to genus and species level, read mapping, relative abundance 20 estimation, and gene calling. No algorithm out performed the others in all categories, and the 21 algorithm or algorithms of choice strongly depends on analysis goals. MetaPhlAn excels for bacteria 22 and LMAT for viruses. The algorithms were ranked by overall performance using a normalized 23 weighted sum of the above metrics, and MetaScope emerged as the overall winner, followed by Kraken 24 and LMAT. 25 Conclusions 27 Simulated FASTQ datasets with well--characterized truth data about microbial community composition 28 reveal numerous insights about the relative strengths and weaknesses of the metagenomics algorithms 29 evaluated. The simulated datasets are available to download from the Sequence Read Archive 30 (SRP062063). 31 32 
 Title: Evaluating performance of metagenomic characterization algorithms using in silico datasets generated with FASTQSim

A: False
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Q: Paragraph: study, we present the results of comprehensive bioinformatics analyses of the abundance and roles of intrinsic disorder in 3,411 ribosomal proteins from 32 species. We show that many ribosomal proteins are intrinsically disordered or hybrid proteins that contain ordered and disordered domains. Predicted globular domains of many ribosomal proteins contain noticeable regions of intrinsic disorder. We also show that disorder in ribosomal proteins has different characteristics compared to other proteins that interact with RNa and DNa including overall abundance, evolutionary conservation, and involvement in protein-protein interactions. Furthermore, intrinsic disorder is not only abundant in the ribosomal proteins, but we demonstrate that it is absolutely necessary for their various functions. Abstract Intrinsic disorder (i.e., lack of a unique 3-D structure) is a common phenomenon, and many biologically active proteins are disordered as a whole, or contain long disordered regions. these intrinsically disordered proteins/regions constitute a significant part of all proteomes, and their functional repertoire is complementary to functions of ordered proteins. In fact, intrinsic disorder represents an important driving force for many specific functions. an illustrative example of such disordercentric functional class is RNa-binding proteins. In this Z. Peng and C. J. Oldfield contributed equally to this study. Electronic supplementary material the online version of this article ( 
 Title: A creature with a hundred waggly tails: intrinsically disordered proteins in the ribosome

A:
False
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