instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: Imatinib mesylate is a new drug that can inhibit the tyrosine kinase activity of Bcr-Abl, the receptors for platelet-derived growth factor receptor(PDGF) and stem cell factor, or c-kit. Chronic myeloid leukemia (CML) is distinguished by the presence of a reciprocal translocation between chromosomes 9 and 22 that results in a shortened chromosome 22, termed the Philadelphia(Ph) chromosome. As a result of the translocation, a fusion gene called the Bcr-Abl gene is created from two normal cellular genes, encoding a chimeric Bcr-Abl protein with a deregulated tyrosine kinase activity. The expression of Bcr-Abl tyrosine kinase has been shown to be necessary and sufficient for the transformed phenotype of CML cells. Imatinib can block the kinase activity of Bcr-Abl, thus inhibiting the proliferation of Ph-positive progenitors, and has shown activity against all phases of CML, though responses are most substantial and durable in patients in the chronic phase. An international phase III study which compared the efficacy of imatinib with that of interferon alpha combined with low-dose cytarabine in newly diagnosed chronic-phase CML showed the rate of major cytogenetic response at 24 months was 90%, including 82% of complete cytogenetic response. These results indicated that imatinib was superior to interferon-containing treatment as a first-line therapy. More than 10,000 patients worldwide, including those in Japan, have been treated with imatinib in clinical trials, and a lot of information has been accumulated on the use of this drug. The aim of this article is to review the use of this drug and the practical management of patients with chronic myeloid leukemia. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
answer:
bcr-abl


question:
Context: People all over the world today are beginning to hear and learn more and more about the problem of pollution.Pollution is caused either by man's release of completely new artificial substances into the environment,or by releasing greatly increased amounts of a natural substance,such as oil from oil tankers into the sea. The whole industrial process which makes many of the goods and machines we need and use in our daily lives,is bound to create a number of waste products which upset the environmental balance,or the ecological balance as is also known.Many of these waste products can be prevented or disposed of.But while more and more new and complex goods are produced,there will be new,dangerous waste to be disposed of,for example,the waste products from nuclear power stations.Many people,therefore,see pollution as only part of a larger and more complex problem,that is,the whole process of industrial production and consumption of goods.Others again see the problem mainly in connection with agriculture,where new methods are helping farmers grow more and more on their land to feed our ever-increasing population.However,the land itself is gradually becoming worn out as it is being used,in some cases,too heavily,and artificial fertilizers can not restore the balance. Whatever its underlying reasons are,there is no doubt that much of the pollution caused could be controlled if only companies,individuals and governments would make more efforts.In the home there is an obvious need to control litter and waste.Food comes wrapped up three or four times in packages that all have to be disposed of;drinks are increasingly sold in bottles or tins which can not be reused.This not only causes a litter problem,but also is a great waste of resources,in terms of glass,metals and paper.Advertising has helped this process by persuading many of us not only to buy things we neither want nor need,but also to throw away much of what we do buy.Pollution and waste combine to be a problem everyone can help to solve by cutting out unnecessary buying,excessive consumption and careless disposal of the products we use in our daily lives. 
 Question: Many people see pollution as only part of .
answer:
the whole process of industrial production and consumption of goods


question:
Context: Coming off their win over the Browns, the Bears stayed at home for a Week 9 duel with the Arizona Cardinals. Chicago would trail early in the first quarter as Cardinals quarterback Kurt Warner hooked up with wide receiver Larry Fitzgerald on an 11-yard touchdown pass. The Bears would answer as quarterback Jay Cutler competed a 33-yard touchdown pass to tight end Greg Olsen, but Arizona came right back as Warner hooked up with tight end Ben Patrick on a 6-yard touchdown pass. Chicago would find themselves in a huge deficit in the second quarter as Warner completed a 17-yard touchdown pass to Fitzpatrick and a 15-yard touchdown pass to tight end Anthony Becht, followed by kicker Neil Rackers nailing a 43-yard field goal. The Cardinals would add onto their lead as Rackers booted a 30-yard field goal in the third quarter. The Bears tried to rally in the fourth quarter as Cutler connected with Olsen on a 3-yard and a 20-yard touchdown pass, but Arizona pulled away with Warner completing a 4-yard touchdown pass to wide receiver Steve Breaston. 
 Question: Who threw the longest touchdown pass?
answer:

jay cutler