In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
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Question: Protein microarrays are powerful tools that are widely used in systems biology research. For infectious diseases, proteome microarrays assembled from proteins of pathogens will play an increasingly important role in discovery of diagnostic markers, vaccines, and therapeutics. Distinct formats of protein microarrays have been developed for different applications, including abundance-based and function-based methods. Depending on the application, design issues should be considered, such as the need for multiplexing and label or label free detection methods. New developments, challenges, and future demands in infectious disease research will impact the application of protein microarrays for discovery and validation of biomarkers.

Answer: Protein Microarrays and Biomarkers of Infectious Disease


Question: The family Potyviridae encompasses~30% of plant viruses and is responsible for significant economic losses worldwide. Recently, a small overlapping coding sequence, termed pipo, was found to be conserved in the genomes of all potyvirids. PIPO is expressed as part of a frameshift protein, P3N-PIPO, which is essential for virus cell-to-cell movement. However, the frameshift expression mechanism has hitherto remained unknown. Here, we demonstrate that transcriptional slippage, specific to the viral RNA polymerase, results in a population of transcripts with an additional "A" inserted within a highly conserved GAAAAAA sequence, thus enabling expression of P3N-PIPO. The slippage efficiency is~2% in Turnip mosaic virus and slippage is inhibited by mutations in the GAAAAAA sequence. While utilization of transcriptional slippage is well known in negative-sense RNA viruses such as Ebola, mumps and measles, to our knowledge this is the first report of its widespread utilization for gene expression in positive-sense RNA viruses.

Answer: Transcriptional slippage in the positive-sense RNA virus family Potyviridae


Question: Journal Pre-proof 1 such as ventilators in limited supply, preparations should be made ahead of time on how to allocate these finite resources. More information about COVID-19 can be found in [2], [3], and [7] . The best course of action to "flatten the curve" is to follow WHO guidelines. The best way to keep hospitals under capacity is social distancing: limiting or cancelling large gatherings, only travelling when necessary, and keeping a distance from others all help to prevent the spread. The presented heuristic is based on the exponential growth of the data collected Journal Pre-proof J o u r n a l P r e -p r o o f 4 WWK, MAM, WP, AW-D, PFZ, DS, TA, AHZ, MD, AND JM by WHO situation reports for days 31 to 57. As pointed out in [4] the predictability could be improved by pairwise comparisons based on abductive reasoning [5]. Abduction is frequently used in diagnostic expert systems. The abductive reasoning (or inference) process was used for this study. It is a type of logical inference which starts with a set of observations and then searches for Journal Pre-proof J o u r n a l P r e -p r o o f 1,000,000 COVID-19 CASES X Journal Pre-proof J o u r n a l P r e -p r o o f

Answer:
Journal Pre-proof 1000,000 cases of COVID-19 outside of China: The date predicted by a simple heuristic 1,000,000 CASES OF COVID-19 OUTSIDE OF CHINA: THE DATE PREDICTED BY A SIMPLE HEURISTIC