Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

The Bacillus anthracis toxin genes, cya, lef, and pag, can be viewed as a regulon, in which transcription of all three genes is activated in trans by the same regulatory gene, atxA, in response to the same signal, CO2. In atxA+ strains, toxin gene expression is increased 5- to 20-fold in cells grown in 5% CO2 relative to cells grown in air. CO2-enhanced toxin gene transcription is not observed in atx4-null mutants. Here, we used two independent techniques to obtain evidence for additional CO2-induced atxA-regulated genes. First, total protein preparations from atxA4+ and atxA isolates grown in 5% CO2 and in air were examined by two-dimensional electrophoresis. Comparison of the resulting protein patterns indicated that synthesis of non-toxin proteins is influenced by growth in elevated CO2 and the toxin gene regulator, atxA. Second, we generated random transcriptional lacZ fusions in B. anthracis with transposon Tn917-LTV3. Transposon-insertion libraries were screened for mutants expressing CO2-enhanced atxA-dependent beta-galactosidase activity. DNA sequence analysis of transposon insertion sites in 17 mutants carrying CO2- and atxA-regulated fusions revealed 10 mutants carrying independent insertions on the 185-kb toxin plasmid pXO1 which did not map to the toxin genes. The tcr-lacZ fusion mutants (tcr for toxin coregulated) were Tox+, indicating that these genes may not be involved in anthrax toxin gene activation. Our data indicate a clear association of atxA with CO2-enhanced gene expression in B. anthracis and provide evidence that atxA regulates genes other than the structural genes for the anthrax toxin proteins.
Which metabolite activates AtxA?

P&O European Ferries (formerly Townsend Thoresen), a division of P&O Ferries, was a ferry company which operated in the English Channel from 1987 after the Herald of Free Enterprise disaster, when Townsend Thoresen was renamed P&O European Ferries, until 1999 when the Portsmouth Operations became P&O Portsmouth and the Dover Operation where merged with Stena Line AB to make P&O Stena Line.
What is the ending year of P&O European Ferries?

How fast or slow something moves is its speed. Speed determines how far something travels in a given amount of time. The SI unit for speed is meters per second (m/s). Speed may be constant, but often it varies from moment to moment. Even if speed varies during the course of a trip, its easy to calculate the average speed by using this formula: speed = distance time For example, assume you go on a car trip with your family. The total distance you travel is 120 miles, and it takes 3 hours to travel that far. The average speed for the trip is: 120 mi 3h = 40 mi/h speed = Q: Terri rode her bike very slowly to the top of a big hill. Then she coasted back down the hill at a much faster speed. The distance from the bottom to the top of the hill is 3 kilometers. It took Terri 41 hour to make the round trip. What was her average speed for the entire trip? (Hint: The round-trip distance is 6 km.) A: Terris speed can be calculated as follows: 6 km 0.25 h = 24 km/h speed = When you travel by car, you usually dont move at a constant speed. Instead you go faster or slower depending on speed limits, traffic lights, the number of vehicles on the road, and other factors. For example, you might travel 65 miles per hour on a highway but only 20 miles per hour on a city street (see the pictures in the Figure 1.1.) You might come to a complete stop at traffic lights, slow down as you turn corners, and speed up to pass other cars. Therefore, your speed at any given instant, or your instantaneous speed, may be very different than your speed at other times. Instantaneous speed is much more difficult to calculate than average speed. Cars race by in a blur of motion on an open highway but crawl at a snails pace when they hit city traffic. If you know the average speed of a moving object, you can calculate the distance it will travel in a given period of time or the time it will take to travel a given distance. To calculate distance from speed and time, use this version of the average speed formula given above: distance = speed time For example, if a car travels at an average speed of 60 km/h for 5 hours, then the distance it travels is: distance = 60 km/h 5 h = 300 km To calculate time from speed and distance, use this version of the formula: time = distance speed Q: If you walk 6 km at an average speed of 3 km/h, how much time does it take? A: Use the formula for time as follows: distance speed 6 km = 3 km/h =2h time =

the si unit for speed is