Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: Imatinib was the first BCR-ABL tyrosine kinase inhibitor to become clinically available. In this study, we retrospectively evaluated the long-term efficacy of low-dose imatinib (final maintenance dose <300mg per day) due to intolerance, in comparison to optimal-dose imatinib (300mg per day) in patients with Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase. The Kaplan-Meier estimates of the median time to complete cytogenetic response, major molecular response, and complete molecular response were longer for 31 patients receiving low-dose imatinib (360, 1360, and 1420days, respectively) than 74 patients receiving optimal-dose imatinib (170, 420, and 720days, respectively). However, the differences in response shrank over time and progression-free survival were comparable between the two groups. These findings suggest that long-term treatment with low-dose imatinib is an acceptable alternative for patients with intolerance to the optimal dose.
Example Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

Example Input: The Men in Black are a secret law-enforcement agency that is responsible for policing the extraterrestrial life hidden on Earth, as well as protecting the world from any aliens who attempt to destroy/invade the planet.The film begins on LunarMax, a MiB prison situated on the moon. A one-armed criminal, a Boglodite named Boris the Animal, stages a jailbreak (along the way killing Obadiah Price, a fellow inmate he'd made a deal with). His intention is to rewrite history, with Agent K, the one who arrested and imprisoned him, being a major factor in his plan...On Earth, Agent K and his partner Agent J cover up an arrival of an alien spacecraft, and hear of the prison break. At a Chinese restaurant thats a local haunt for aliens, Agent K discovers Boris (who had previously gone to see Obadiah's son Jeffrey) and the two fight, with J joining in. K is upset that the alien he should have killed is out loose again; he deems it his own affair and forbids J to help him, suspending him. A puzzled J checks up on Boris: he appeared in 1969 to stop the prevention of the ArcNet Shield, a device that K deployed to protect the world from harm (but which killed off the Boglodites, as they can only survive by feeding off worlds). He managed to kill on 15 July 1969 an alien named Roman the Fabulous and on the following day... at this point O cuts him off and tells him not to investigate any further. That night, as K waits for Boris with a gun in his hand, he suddenly vanishes...The next morning, J discovers that he has a new partner, the liberated Agent AA, and that K has been dead for forty years (having been killed by Boris the Animal on 16th July 1969). O notices he is suffering from headaches and craves chocolate milk, which she explains are symptoms of time-fracture (aka the crime of interfering with history, which Obadiah Price was imprisoned for). At this point a Boglodite armada appears; J learns that there was nothing to hold them at bay, with no K to deploy the ArcNet. He theorizes that Boris went back in time to 1969 to kill K, thus changing history to what it was, and proposes to follow him; he heads to Jeffrey Price, who had provided Boris a time-jump device, and gets another one from him, and activates it by jumping off the Chrysler Building just as the Boglodites begin their assault...J arrives in 15 July 1969, with the intention to catch Boris as he is about to murder Roman the Fabulous. However, he is delayed from navigating the era of 1969 (most notably by an altercation with two racist cops), and gets there too late to stop Romans murder by 1969 Boris. He encounters 1969 Agent K, who subdues him and brings him to MiB headquarters. J tells K nothing, but when threatened with getting his memory erased he tells K part of the truth: he came from the future in pursuit of another time-traveler whos trying to change history.K and J follow a trail of clues to Andy Warhols Factory complex, where Warhol is revealed to be MiB Agent W. He notifies them of Griffin, an Arcanian being who has the ability to foresee all timelines and futures; Griffins planet was destroyed by the Boglodites, so he came to live on Earth and brought with him a device which will prevent the Boglodites from consuming the Earth. 1969 Boris arrives at the Factory in search of Griffin, who makes a quick exit with Boris in fast pursuit (to Js displeasure, although K doesnt seem to get too worried).J and K eventually track down Griffin at Shea Stadium, where he is foreseeing the future victory for the Mets baseball team. 1969 Boris appears and captures Griffin, but J and K are able to rescue Griffin, although Boris gets away. Griffin gives them the ArcNet and explains it can only work in zero gravity: K gets the idea to head to Cape Canaveral on 16th July 1969 (the day the Apollo 11 ship launched)
Example Output: Who attacks the agents as they climb up the tower?

Example Input: Alice de Toeni, Countess of Warwick (26 April 1284 -- 1 January 1324/25) was a wealthy English heiress and the second wife of Guy de Beauchamp, 10th Earl of Warwick (1272 -- 12 August 1315), an English nobleman in the reign of Kings Edward I and Edward II. He was one of the principal opponents of Piers Gaveston, a favourite of Edward II. Alice married three times;
Example Output:
What is Alice de Toeni, Countess of Warwick's spouse's name?