instruction:
Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
question:
Question: Does dll1 haploinsufficiency in adult mice lead to a complex phenotype affecting metabolic and immunological processes?
Answer: In conclusion, slight alterations in one player of Notch signaling alter the entire organism, emphasizing the fine-tuning character of this pathway in a high number of processes.
answer:
yes


question:
Question: Does cYP3A5 genotype influence everolimus in vitro metabolism and clinical pharmacokinetics in renal transplant recipients?
Answer: This study provides direct and indirect evidence that CYP3A5 genotyping cannot help improve everolimus therapy.
answer:
no


question:
Question: Is a globally occurring indel polymorphism in the promoter of the IFNA2 gene associated with severity of malaria but with the positivity rate of HCV?
Answer: Polymorphisms in genes involved in the interferon pathway have been implicated in the resistance or susceptibility against cerebral malaria and HBV. Here we show that an indel polymorphism, which mediates a disadvantageous effect in HBV patients, may also play a disadvantageous role in HCV infections stressing the importance of a fully functional interferon pathway.
answer:

no