Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
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Question: Comparing baseline CGI with that obtained on the date of last evaluation for each patient, a significant improvement in clinical assessment of severity of illness was obtained for the total group (Wilcoxon signed rank test, p < 0.0001).

Answer: non-adverse drug event


Question: Ibuprofen-induced meningitis: detection of intrathecal IgG synthesis and immune complexes.

Answer: adverse drug event


Question: Bull's-eye maculopathy associated with quinacrine therapy for malaria.

Answer:
adverse drug event