Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Ex Input:
Pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia.

Ex Output:
adverse drug event


Ex Input:
DISCUSSION: Anaphylactoid reactions have been described previously with cisplatin administration.

Ex Output:
adverse drug event


Ex Input:
To avoid that toxicity, a new weekly schedule has been adopted in several Phase II studies.

Ex Output:

non-adverse drug event