instruction:
In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
question:
Autophagy and autophagy-related processes are fundamentally important in human health and disease. These processes are viewed primarily as cellular degradative pathways that recycle macromolecules and dysfunctional or redundant organelles into amino acids, sugars and lipids, especially during starvation. However, the ubiquitin-like autophagy proteins and other components of the autophagic machinery additionally participate in cellular reprogramming. We highlight these non-autophagic roles of autophagy proteins with the aim of drawing attention to this growing, but unexplored, research topic. We focus on the non-autophagic functions of autophagy proteins in cell survival and apoptosis, modulation of cellular traffic, protein secretion, cell signalling, transcription, translation and membrane reorganization.
answer:
review review Non-autophagic roles of autophagy-related proteins


question:
The massive abundance of studies relating to tropical medicine and health has increased strikingly over the last few decades. In the field of tropical medicine and health, a well-conducted systematic review and meta-analysis (SR/MA) is considered a feasible solution for keeping clinicians abreast of current evidence-based medicine. Understanding of SR/MA steps is of paramount importance for its conduction. It is not easy to be done as there are obstacles that could face the researcher. To solve those hindrances, this methodology study aimed to provide a step-by-step approach mainly for beginners and junior researchers, in the field of tropical medicine and other health care fields, on how to properly conduct a SR/MA, in which all the steps here depicts our experience and expertise combined with the already well-known and accepted international guidance. We suggest that all steps of SR/MA should be done independently by 2-3 reviewers' discussion, to ensure data quality and accuracy. Conclusion: SR/MA steps include the development of research question, forming criteria, search strategy, searching databases, protocol registration, title, abstract, full-text screening, manual searching, extracting data, quality assessment, data checking, statistical analysis, double data checking, and manuscript writing.
answer:
A step by step guide for conducting a systematic review and meta-analysis with simulation data


question:
Bagaza virus is a mosquito-borne flavivirus, first isolated in 1966 in Central African Republic. It has currently been identified in mosquito pools collected in the field in West and Central Africa. Emergence in wild birds in Europe and serological evidence in encephalitis patients in India raise questions on its genetic evolution and the diversity of isolates circulating in Africa. To better understand genetic diversity and evolution of Bagaza virus, we describe the full-genome characterization of 11 West African isolates, sampled from 1988 to 2014. Parameters such as genetic distances, N-glycosylation patterns, recombination events, selective pressures, and its codon adaptation to human genes are assessed. Our study is noteworthy for the observation of N-glycosylation and recombination in Bagaza virus and provides insight into its Indian origin from the 13th century. Interestingly, evidence of Bagaza virus codon adaptation to human house-keeping genes is also observed to be higher than those of other flaviviruses well known in human infections. Genetic variations on genome of West African Bagaza virus could play an important role in generating diversity and may promote Bagaza virus adaptation to other vertebrates and become an important threat in human health. 2 of 26 meningoencephalitis virus (ITV), a pathogen affecting poultry (turkeys) and close to West Nile virus (WNV) in several genomic regions [3, 11] . Although diverse studies have contributed greatly to our understanding of the transmission modes of BAGV [8, 12] and the pathogenesis of BAGV infection [13] , only one study has addressed BAGV genetic diversity, reporting a high homology >90% between Central African Republic, Indian and Spanish BAGV isolates [9] . In West Africa, there is a lack of data on BAGV genetic diversity. To fill this gap and gain better insights into BAGV molecular evolution, we characterized the full-genome of 11 BAGV isolates, sampled from 1988 to 2014 in Senegal and Côte d'Ivoire. Firstly, we assessed genetic distances, phylogenetically informative sites found in more than one sequence contributing to branch ordering, N-glycosylation patterns, recombination events, selective pressures on West African BAGV sequences and their evolutionary phylogenetic relationships with previously available BAGV genomes. Secondly, to assess evidence of future BAGV codon adaptation to human house-keeping genes, a bio-informatics approach was used for analysis of codon adaptation biases.
answer:

Full-Genome Characterization and Genetic Evolution of West African Isolates of Bagaza Virus