TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Many patients with restless legs syndrome (Willis-Ekbom disease) complain of burning sensations in their feet associated with the desire to move, such that they seek cooler environments. This pilot study aimed to characterise the microvascular skin changes in 12 patients with restless legs syndrome compared with 12 age- and sex-matched controls. Patients with moderate or severe restless legs syndrome and controls underwent detailed thermovascular assessment in a controlled temperature room at three different stages (normothermic phase 23C, hot phase 30C, cold phase 18C). Microvascular activity was recorded during all phases by bilateral great toe laser-Doppler flowmetry and also by whole-body thermography. Patient and control measurements were compared. The study protocol was well tolerated. Parameters extracted from the laser-Doppler flowmetry measurements were used to model a logistic function using binary logistic regression. This demonstrated a statistically significant difference between patients with restless legs syndrome and healthy controls (P<0.001). Visual inspection of the body thermography image sequences showed increased lower limb movement in patients with restless legs syndrome patients compared with controls. Thermography analysis also showed significant differences between foot temperatures in patients with restless legs syndrome compared with controls during the hot phase (P=0.011). Notably, patients with restless legs syndrome had more uniform foot temperatures, whereas controls had a wider variability in surface temperature across the feet. This novel study demonstrates impaired microvascular circulation in patients with restless legs syndrome in comparison to matched controls and a potential mechanism for the sensation of burning feet. The protocol also provides an experimental paradigm to test therapeutic interventions for the future.

SOLUTION: Willis-Ekbom disease is also known as?

PROBLEM: The first year after birth is called infancy. Infancy is a period when the baby grows very fast. During infancy, the baby doubles in length and triples in weight. Other important changes also happen during infancy: The babys teeth start to come in, usually at about six months of age ( Figure 1.1). The baby starts smiling, paying attention to other people, and grabbing toys. The baby begins making babbling sounds. By the end of the first year, the baby is starting to say a few words, such as mama and dada. The baby learns to sit, crawl, and stand. By the end of the first year, the baby may be starting to walk. Childhood begins after the babys first birthday and continues until the teen years. Between one and three years of age, a child is called a toddler. During the toddler stage, growth is still fast, but not as fast as it was during infancy. A toddler learns many new words. The child even starts putting together words in simple sentences. Motor skills also develop quickly during this stage. By age three, most children can run and climb steps. They can hold crayons and scribble with them. They can also feed themselves and use the toilet. From age three until the teens, growth is slower. The body also changes shape. The arms and legs get longer compared to the trunk. Children continue to develop new motor skills. For example, many young children learn how to ride a tricycle and then a bicycle. Most also learn how to play games and sports ( Figure 1.2). By age six, children start losing their baby teeth. Their permanent teeth begin coming in to replace them. They also start school and learn how to read and write. They develop friendships and become less dependent on their parents. There are numerous milestones that occur during the first few years of childhood. These include the use of language, walking and running, understanding simple concepts, pretend play, the development of fine motor skills, the development of independence, Children develop better motor skills as they get older. having temper tantrums, demonstrating separation anxiety, becoming fully potty-trained, showing natural curiosity.

SOLUTION: during infancy, a baby

PROBLEM: Its hard to grasp the vast amounts of time since Earth formed and life first appeared. It may help to think of Earths history as a 24-hour day. Figure 7.17 shows the history of Earth in a day. In this model, the planet forms at midnight. The first prokaryotes evolve around 3:00 am. Eukaryotes evolve at about 1:00 pm. Animals dont evolve until almost 8:00 pm. Humans appear only in the last minute of the day. Relating these major events in Earths history to a 24-hour day helps to put them in perspective. Another tool for understanding the history of Earth and its life is the geologic time scale. You can see this time scale in Figure 7.18. It divides Earths history into eons, eras, and periods. These divisions are based on major changes in geology, climate, and the evolution of life. The geologic time scale organizes Earths history on the basis of important events instead of time alone. It also puts more focus on recent events, about which we know the most. The Precambrian Supereon is the first major division of Earths history (see Figure 7.18). It covers the time from Earths formation 4.6 billion years ago to 544 million years ago. To see how life evolved during the Precambrian and beyond, watch this wonderful video. Its a good introduction to the rest of the lesson. MEDIA Click image to the left or use the URL below. URL: When Earth first formed, it was a fiery hot, barren ball. It had no oceans or atmosphere. Rivers of melted rock flowed over its surface. Gradually, the planet cooled and formed a solid crust. Gases from volcanoes formed an atmosphere, although it contained only a trace of oxygen. As the planet continued to cool, clouds formed and rain fell. Rainwater helped form oceans. The ancient atmosphere and oceans would be toxic to modern life, but they set the stage for life to begin. All living things consist of organic molecules. Many scientists think that organic molecules evolved before cells, perhaps as early as 4 billion years ago. Its possible that lightning sparked chemical reactions in Earths early atmosphere. This could have created a soup of organic molecules from inorganic chemicals. Some scientists think that RNA was the first organic molecule to evolve. RNA can not only encode genetic instructions. Some RNA molecules can carry out chemical reactions. All living things are made of one or more cells. How the first cells evolved is not known for certain. Scientists speculate that lipid membranes grew around RNA molecules. The earliest cells may have consisted of little more than RNA inside a lipid membrane. You can see a model of such a cell in Figure 7.19. The first cells probably evolved between 3.8 and 4 billion years ago. Scientists think that one cell, called the Last Universal Common Ancestor (LUCA), gave rise to all of the following life on Earth. LUCA may have existed around 3.5 billion years ago. The earliest cells were heterotrophs. They were unable to make food. Instead, they got energy by "eating" organic molecules in the soup around them. The earliest cells were also prokaryotes. They lacked a nucleus and other organelles. Gradually, these and other traits evolved. Photosynthesis evolved about 3 billion years ago. After that, certain cells could use sunlight to make food. These were the first autotrophs. They made food for themselves and other cells. They also added oxygen to the atmosphere. The oxygen was a waste product of photosynthesis. Oxygen was toxic to many cells. They had evolved in its absence. Many of them died out. The few that survived evolved a new way to use oxygen. They used it to get energy from food. This is the process of cellular respiration. The first eukaryotic cells probably evolved about 2 billion years ago. Thats when cells evolved organelles and a nucleus. Figure 7.20 shows one theory about the origin of organelles. According to this theory, a large cell engulfed small cells. The small cells took on special roles that helped the large cell function. In return, the small cells got nutrients from the large cell. Eventually, the large and small cells could

SOLUTION:
___first major division of Earths history