In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Paragraph: Many new RNA pseudoknot structures have been detected and proposed in the past year. Although we are still waiting for the first detailed structure of a pseudoknot, their role in processes such as translational autoregulation or ribosomal frameshifting has been extensively studied and is now well established. Pseudoknot structures appear to play a pivotal role in small subunit ribosomal RNA and in the noncoding regions of viral RNAs. There are also strong indications that RNA pseudoknots are highly suitable structural motifs for the recognition and binding of proteins. 
 Title: RNA pseudoknots
False

Paragraph: Viral pathogens often generate strong CD4 + T cell responses that are best known for their ability to help B cell and CD8 + T cell responses. However, recent studies reveal additional roles for CD4 + T cells, some of which are independent of other lymphocytes, and indicate that memory cells are more effective in most functions than naïve CD4 T cells. Here, we review the full spectrum of antiviral functions of CD4 + T cells, including their helper activities, innate immune induction, and direct anti-viral roles, and suggest how these functions are integrated to provide highly protective responses against viral pathogens. 
 Title: Expanding roles for CD4 + T cells in immunity to viruses NIH Public Access
False

Paragraph: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the 34 ongoing pandemic of coronavirus disease 2019 (COVID-19), a public health emergency of 35 international concern declared by the World Health Organization (WHO). An immuno-36 informatics approach along with comparative genomic was applied to design a multi-epitope-37 based peptide vaccine against SARS-CoV-2 combining the antigenic epitopes of the S, M and E 38 proteins. The tertiary structure was predicted, refined and validated using advanced 39 bioinformatics tools. The candidate vaccine showed an average of ≥ 90.0% world population 40 coverage for different ethnic groups. Molecular docking of the chimeric vaccine peptide with the 41 immune receptors (TLR3 and TLR4) predicted efficient binding. Immune simulation predicted 42 significant primary immune response with increased IgM and secondary immune response with 43 high levels of both IgG1 and IgG2. It also increased the proliferation of T-helper cells and 44 cytotoxic T-cells along with the increased INF-γ and IL-2 cytokines. The codon optimization and 45 mRNA secondary structure prediction revealed the chimera is suitable for high-level expression 46 and cloning. Overall, the constructed recombinant chimeric vaccine candidate demonstrated 47 significant potential and can be considered for clinical validation to fight against this global 48 threat, COVID-19. 49 50 51 52 53 
 Title: Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2 1 etiologic agent of global pandemic COVID-19: an in silico approach 2 3

False