In this task, you are given a passage which has a question and the context. You have to generate an answer to the question based on the information present in the context.

Ex Input:
Context: Breast cancer is a hormone-dependent cancer, and the presence of estrogen receptor alpha (ER-alpha) in tumors is used clinically to predict the likelihood of response to hormonal therapies. The clinical value of the second recently identified ER isoform, called ER-beta, is less clear, and there is currently conflicting data concerning its potential role as a prognostic or predictive factor.', 'To assess whether ER-beta expression is associated with clinical outcome, protein levels were measured by immunoblot analysis of a retrospective bank of tumor cell lysates from 305 axillary node-positive patients. A total of 119 received no adjuvant therapy, and 186 were treated with tamoxifen only. The median follow-up time was 65 months. Univariate and multivariate Cox regression modeling was done to assess the prognostic and predictive significance of ER-beta expression.', 'Expression of ER-beta protein did not correlate significantly with any other clinical variables, including ER and progesterone levels (as measured ligand binding assay), tumor size, age, or axillary nodal status. In the untreated population, those patients whose tumors who expressed both receptor isoforms exhibited the most favorable outcome as compared with those patients who had lost ER-alpha expression. However, there was no association between ER-beta levels alone and either disease-free or overall survival in the untreated patient population. In contrast, in both univariate and multivariate analyses, high levels of ER-beta predicted an improved disease-free and overall survival in patients treated with adjuvant tamoxifen therapy.\Question: Do low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer?

Ex Output:
These findings provide evidence that ER-beta may be an independent predictor of response to tamoxifen in breast cancer. Furthermore, these results suggest that ER-beta may influence tumor progression in ways different from those mediated by the ER-alpha isoform.


Ex Input:
Context: The majority of cancer chemotherapy can lead to bone marrow depression, which often affects clinical response as chemotherapy can not be carried out with enough dosage on time. The platelets decrease is one of the problems caused by bone marrow depression. Though the clinical response of hyodermic "IL-11" is affirmed to advance platelets presently, it is limited by expensive price. Other agents that can be taken orally with suitable price and equal authenticity are less reported. The author observed clinical response of platelets decrease adopting traditional Chinese medicine "Sheng Ban Recipe"(SBR).', 'Totally 103 patients with platelets decrease after chemotherapy from July 1994 to Jannary 2002. They were randomly divided into two groups: SBR plus common treatment group and common treatment alone group. The previous group take 1 package SBR for twice drink per day. Common treatment group give common therapy only. The follow-up period is 2 weeks.', 'Among the 55 cases in SBR group, noticeable efficiency 20%, efficiency 50.9%, total efficiency 70.9%, which is evidently superior to common group.\Question: Do [ Observation of clinical response of `` sheng ban recipe '' for platelets decrease after chemotherapy ]?

Ex Output:
"Sheng Ban Recipe" can effectively treat thrombocytopenia after chemotherapy, which helps to reduce the necessary of intravenous drip of platelets and the risk of hemorrhage.


Ex Input:
Context: During clinical electrophysiologic study, multiple clinical tachycardia morphologies often can be induced in the infarct border zone, and all morphologies must be targeted for ablation therapy to be successful. Analysis of sinus rhythm electrogram shape for localizing figure-of-eight reentrant circuits in cases of multiple morphologies is proposed.', 'Sinus rhythm activation maps were constructed from bipolar electrograms acquired at 196 to 312 sites in the epicardial border zone in 10 postinfarction canine hearts. In each heart, at least two distinct figure-of-eight reentrant ventricular tachycardia morphologies were inducible by premature electrical stimulation, as determined by activation maps of sustained tachycardias. Sinus rhythm maps were used to predict the location of the isthmus (central common pathway [CCP]), which is the protected region of the circuit bounded by arcs of block (mean accuracy 76.7 +/- 4%). Although reentrant circuits differed, the positions of the entrance point of each CCP were common. The location of the line that would span the CCP at its narrowest width also was estimated (mean accuracy 91.3 +/- 5%). Ablation at this line is expected to prevent reentry recurrence. In one test experiment, ablation prevented recurrence of both sustained reentrant tachycardia morphologies.\Question: Are sinus rhythm electrogram shape measurements predictive of the origins and characteristics of multiple reentrant ventricular tachycardia morphologies?

Ex Output:

Sinus rhythm electrogram analyses are useful for (1) localizing multiple reentrant circuits with differences in morphology that are inducible by premature stimulation in the infarct border zone, and (2) locating and orienting the position of a linear lesion for preventing recurrence of all morphologies with minimal damage to the heart.