Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

Paragraph: Pfizer shares were up nearly 4 percent on positive findings for the oral treatment, called palbociclib, one of the company’s most important experimental drugs that some analysts believe could eventually claim annual sales of more than $5 billion, if approved. The trial tested the pill in post-menopausal patients with locally advanced or newly diagnosed breast cancer that had spread to other parts of the body. “We are delighted with the final data,” Pfizer said in a release, adding the company will discuss the successful data on progression-free survival with the U.S. Food and Drug Administration “to determine next steps” for palbociclib. A secondary goal of the study is to determine whether palbociclib can prolong overall survival. But Pfizer spokeswoman Sally Beatty said the company does not yet have such data, because it takes longer periods to follow patients and gauge survival trends. Although Pfizer is conducting two larger late-stage trials of palbociclib, ISI Group analyst Mark Schoenebaum noted the company has previously said it might discuss with the FDA the potential to seek approval of the medicine based upon mid-stage trial data, if the data warranted. Palbociclib, which blocks enzymes known as cyclin-dependent kinases (CDKs) 4 and 6, was taken in combination with a standard treatment called letrozole among women who were estrogen receptor positive - meaning tumors grow in response to estrogen - and HER2-negative, meaning that the HER2 protein is not causing the cancer. Such patients make up about 60 percent of advanced breast cancer cases. Letrozole is the chemical name of Femara, a Novartis AG drug that belongs to a class of treatments called aromatase inhibitors that block production of estrogen. Pfizer on Monday did not present detailed data from the trial results, saying they would be presented at a scientific meeting in San Diego in April. The success of the trial, called Paloma-1, follows highly favorable interim data that Pfizer unveiled in December 2012. At that point in the study, those taking both palbociclib and letrozole went an average of 26.1 months before tumors worsened. That compared with 7.5 months for those taking letrozole, but not palbociclib. The 18.6-month difference was considered statistically significant. Side effects from palbociclib were similar to those previously reported, Pfizer said on Monday. The earlier interim results had shown that patients taking the drug combination experienced anemia, fatigue and neutropenia - a decline in white blood cells called neutrophils that can put patients at higher risk of infection. Palbociclib was designated a “breakthrough” drug by the FDA last April based on initial data from the trial. The FDA grants “breakthrough” status to drugs that may offer substantial improvement over existing treatments for serious or life-threatening diseases. The status helps to speed up the approval process. Pfizer has started two late-stage trials of the drug - Paloma-2 and Paloma-3 - in patients with advanced breast cancer. Paloma-2 will test the same drug combination, palbociclib and letrozole, as an initial treatment for breast cancer. Paloma-3 will evaluate palbociclib in combination with another hormone therapy, fulvestrant, in women whose cancer has progressed after hormonal therapy. The drug, sold under the brand name Faslodex by AstraZeneca Plc, is called an estrogen receptor antagonist. Companies trying to develop treatments similar to palbociclib include Novartis and Eli Lilly & Co. Breast cancer killed more than 508,000 women worldwide in 2011, according to the World Health Organization. Pfizer shares were up 3.7 percent at $31.53 on Monday morning on the New York Stock Exchange. Claim: Pfizer breast cancer drug succeeds in mid-stage trial.
Pfizer Inc’s experimental breast cancer drug significantly delayed progression of symptoms in a mid-stage trial, meeting the study’s primary goal and keeping Pfizer in the forefront of a race for a new standard of care for the disease.

Paragraph: In March 2020, as cities around the world announced “shelter-in-place” or “self-quarantine” orders in an effort to reduce the spread of COVID-19, social media users started to circulate an image that supposedly showed a newspaper clipping from 1918 with a similar announcement in the town of Kelowna, British Columbia:  The clipping reads: Public Notice. Notice is hearby given that, in order to prevent the spread of Spanish Influenza, all Schools, public and private, Churches, Theaters, Moving Picture Halls, Pool Rooms and other places of amusement, and Lodge meetings, are to be closed until further notice. All public gatherings consisting of 10 or more are prohibited. D. W. Sutherland, Mayor. Kelowna, B.C., 19 October 1918. This is a genuine newspaper clipping that was published in the Kelowna Record in 1918 as this Canadian town, as well as the rest of the world, fought to prevent the spread of the H1N1 virus, commonly and misleadingly called the “Spanish Flu.” The clipping was archived by the University of British Columbia and can be viewed here. Kelowna, of course, was not the only city to issue such an order. We searched the archives of Newspapers.com and found several similar announcements in cities across the United States. On Oct. 10, 1918, for instance, Des Moines, Iowa, Mayor Thomas P. Fairweather announced that “in order to prevent the spread of Spanish Influenza and to protect the public health and safety,” he was directing “all public places of amusement, including theaters, moving pictures houses, dance halls and public dancing places, pool and billiard halls, skating rinks, outdoor athletic events, all public congregating places subject to unusual congestion, be closed.”  Thu, Oct 10, 1918 – Page 6 · The Des Moines Register (Des Moines, Iowa) · Newspapers.com Mobile, Alabama, took these closures one step further. In addition to closing restaurants and businesses, Mobile also asked people to refrain from kissing:  Tue, Oct 8, 1918 – 10 · Knoxville Sentinel (Knoxville, Tennessee) · Newspapers.com In 1918, just like today, individual cities and states made the decision to close schools, businesses, and public gathering places. According to a recent study from the Journal of the American Society of Cytopathology, cities that implemented strict social guidelines during the early days of the 1918 pandemic saw lower transmission rates and reduced total mortalities. Claim: "A newspaper clipping from 1918 documents a ""public notice"" from the city of Kelowna, British Columbia, announcing that schools, movie theaters, and other public places would be closed to prevent the spread of ""Spanish Influenza."" "
During the 1918-19 H1N1 “Spanish” influenza pandemic, which infected a fifth to a third of the world population, and during which 50 million people have died worldwide, including an estimated 675,000 Americans, the United States has adopted a range of nonpharmaceutical (public health) interventions. These measures, which were similar to those currently adopted, included closure of schools and churches, banning of mass gatherings, mandated mask wearing, case isolation, and disinfection/hygiene measures. However, these measures were not implemented at the same time or for the same duration in different cities, nor were they uniformly followed. A recent analysis concluded that in some cities (San Francisco, St. Louis, Milwaukee, and Kansas City), where the measures were implemented early, they reduced transmission rates by up to 30–50%. Cities that implemented such measures earlier had greater delays in reaching peak mortality, and had lower peak mortality rates and lower total mortality. The duration that these “social distancing” measures were kept in place correlated with a reduced total mortality burden. Although we still have no known effective therapy or vaccine prevention for this coronavirus, and the world is a quite different place than it was 100 years ago, the efficacy of the measures instituted during the 1918-19 pandemic gives us hope that the current measures will also limit the impact of the COVID-19 pandemic.

Paragraph: A senior administration official outlined the plan on condition of anonymity ahead of the release of Trump’s 2019 budget plan next week. Pharmaceutical companies now pay rebates to insurers and pharmacy benefit managers to help their medications gain a bigger slice of the market. Insurers apply savings from rebates to keep premiums more manageable. Under Trump’s proposal, seniors covered by Medicare’s popular “Part D” prescription benefit would be able to share in the rebates for individual drugs that they purchase at the pharmacy. Trump’s budget would also expand Medicare’s “catastrophic” drug benefit so that many seniors with very high costs would not face copayments. Seniors with high drug bills are currently still responsible for 5 percent of the cost of their medications. With some new drugs costing $100,000 a year or more, patient costs add up quickly. The White House proposal would put Trump in the middle of a tug-of-war between drug companies on one side and insurers and pharmacy benefit managers on the other, with billions of dollars at stake. Insurers and pharmacy benefit managers say the reason drug costs are so high is that drug companies are free to charge what the market will bear. The pharmaceutical industry says middlemen are the problem, because they keep rebates paid by drug makers instead of passing them on to patients. Insurers counter that rebates are passed on in the form of lower monthly premiums for everybody. The drug industry lobbying group, Pharmaceutical Research and Manufacturers of America, had no immediate reaction. The Trump administration’s new proposals come on top of a long list of Medicare changes in the congressional budget deal. Medicare is the government’s premier health insurance program, covering about 60 million seniors and disabled people. Lawmakers would shift a greater share of Medicare drug costs to the pharmaceutical industry. They also want to eliminate the drug coverage gap known as the “doughnut hole” one year earlier than currently scheduled, in 2019 instead of 2020. “On the whole, I think this is a good bill for people with Medicare,” said Joe Baker, president of the Medicare Rights Center, said of the congressional legislation. “This tilts toward getting a lot of good things done.” But his group opposes a provision that would raise premiums paid by the wealthiest retirees for coverage of outpatient services and prescription drugs. Here’s a look at some of the major Medicare provisions in the budget deal that Republican leaders are trying to push through Congress. Democrats are split over the overall measure, but the Medicare provisions appear to have support from both parties: — PRESCRIPTION DRUGS Originally, beneficiaries in the “doughnut hole” coverage gap were responsible for the full cost of their medications, but the Affordable Care Act passed under former President Barack Obama gradually closes the gap. The budget deal accelerates the timetable by one year, to 2019. Drug makers are already required to provide discounts to close the coverage gap, but the budget deal raises the level of company discounts, which in turn lowers the government’s costs. That should act as a brake on the monthly premiums paid by beneficiaries. “In theory when Medicare spending goes down, premiums would go down, too,” said Tricia Neuman, a Medicare expert with the nonpartisan Kaiser Family Foundation. The drug industry is criticizing the proposal, saying it will mainly benefit insurance companies that act as middlemen providing the benefit. The coverage gap starts when beneficiaries hit $3,750 in total drug costs. — CAPS REPEALED ON REHAB The budget deal permanently repeals limits on therapy services commonly used by stroke patients and people recovering from major surgeries. Those services include physical therapy, occupational therapy and speech therapy. In previous years, Congress had routinely held off on applying the caps. Groups including AARP were pressing for a full repeal. It takes effect this year. __HIGHER PREMIUMS FOR WEALTHIEST RETIREES Premiums for outpatient coverage and prescription drugs would rise for about 1 million wealthy seniors with annual incomes of at least $500,000 for an individual, or $750,000 for a couple filing jointly. Hiking premiums on the well-to-do is an idea that has bipartisan support among lawmakers, but advocates worry that Congress will ultimately start raising costs for middle-class seniors as well. __TELEMEDICINE AND CHRONIC CARE The budget deal expands Medicare’s ability to pay for telemedicine in a wide variety of situations, including for patients with stroke symptoms. It also incorporates a bipartisan Senate bill that is intended to improve care coordination for patients with chronic illnesses, such as heart disease, cancer, and diabetes. —COST CONTROL BOARD REPEALED The deal would repeal the Independent Payment Advisory Board, a Medicare cost-control agency authorized under the Affordable Care Act. It was controversial from the beginning, and the Obama White House did not move forward to set up the board. Claim: Trump aims to reduce drug costs under Medicare.

President Donald Trump will propose lowering prescription drug costs for Medicare beneficiaries by allowing them to share in rebates that drug companies pay to insurers and middlemen, an administration official said Thursday.