In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Example Input: Paragraph: The novel coronavirus 2019-nCoV/SARS-CoV-2 infection has shown discernible variability across the globe. While in some countries people are recovering relatively quicker, in others, recovery times have been comparatively longer and numbers of those succumbing to it high. In this study, we aimed to evaluate the likely association between an individual's ancestry and the extent of COVID-19 manifestation employing Europeans as the case study. We employed 10,215 ancient and modern genomes across the globe assessing 597,573 single nucleotide polymorphisms (SNPs). Pearson's correlation coefficient (r) between various ancestry proportions of European genomes and COVID-19 death/recovery ratio was calculated and its significance was statistically evaluated. We found significant positive correlation (p=0.03) between European Mesolithic hunter gatherers (WHG) ancestral fractions and COVID-19 death/recovery ratio and a marginally significant negative correlation (p=0.06) between Neolithic Iranian ancestry fractions and COVID-19 death/recovery ratio. We further identified 404 immune response related single nucleotide polymorphisms (SNPs) by comparing publicly available 753 genomes from various European countries against 838 genomes from various Eastern Asian countries in a genome wide association study (GWAS). Prominently we identified that SNPs associated with Interferon stimulated antiviral response, Interferon-stimulated gene 15 mediated antiviral mechanism and 2′-5′ oligoadenylate synthase mediated antiviral response show large differences in allele frequencies between Europeans and East Asians. Overall, to the best of our knowledge, this is the first study evaluating the likely association between genetic ancestry and COVID-19 manifestation. While our current findings improve our overall understanding of the COVID-19, we note that the development of effective therapeutics will benefit immensely from a more detailed analyses of individual genomic sequence data from COVID-19 patients of varied ancestries. 
 Title: Investigating the likely association between genetic ancestry and COVID-19 manifestation
Example Output: True

Example Input: Paragraph: The avian influenza virus H5N1 and the 2009 swine flu H1N1 are potentially serious pandemic threats to human health, and air travel readily facilitates the spread of infectious diseases. However, past studies have not yet incorporated the effects of air travel on the transmission of influenza in the construction of mathematical epidemic models. Therefore, this paper focused on the human-to-human transmission of influenza, and investigated the effects of air travel activities on an influenza pandemic in a small-world network. These activities of air travel include passengers' consolidation, conveyance and distribution in airports and flights. Dynamic transmission models were developed to assess the expected burdens of the pandemic, with and without control measures. This study also investigated how the small-world properties of an air transportation network facilitate the spread of influenza around the globe. The results show that, as soon as the influenza is spread to the top 50 global airports, the transmission is greatly accelerated. Under the constraint of limited resources, a strategy that first applies control measures to the top 50 airports after day 13 and then soon afterwards to all other airports may result in remarkable containment effectiveness. As the infectiousness of the disease increases, it will expand the scale of the pandemic, and move the start time of the pandemic ahead. 
 Title: Transmission and control of an emerging influenza pandemic in a small-world airline network
Example Output: False

Example Input: Paragraph: In light of the pathogenic mechanism of feline coronavirus that relies on endosomal acidification for cytoplasmic entry, a novel vacuolar ATPase blocker, diphyllin, and its nanoformulation are herein investigated for their antiviral activity against the type II feline infectious peritonitis virus (FIPV). Experimental results show that diphyllin dose-dependently inhibits endosomal acidification in fcwf-4 cells, alters the cellular susceptibility to FIPV, and inhibits the downstream virus replication. In addition, diphyllin delivered by polymeric nanoparticles consisting of poly(ethylene glycol)-block-poly(lactide-coglycolide) (PEG-PLGA) further demonstrates an improved safety profile and enhanced inhibitory activity against FIPV. In an in vitro model of antibody-dependent enhancement of FIPV infection, diphyllin nanoparticles showed a prominent antiviral effect against the feline coronavirus. In addition, the diphyllin nanoparticles were well tolerated in mice following high-dose intravenous administration. This study highlights the therapeutic potential of diphyllin and its nanoformulation for the treatment of FIP. Feline coronaviruses (FCoVs) belong to the genus alphacoronavirus in the family Coronaviridae. As a ubiquitous viral pathogen among domestic and wild feline populations, FCoV can be horizontally transmitted via the fecal-oral route with persistent infection, and the prevalence and seropositivity in multi-cat households or shelters may achieve 90% 1,2 . With regard to pathogenicity, FCoV exists as two biotypes, namely feline enteric coronavirus (FECV) and feline infectious peritonitis virus (FIPV) 3 . Genetic mutations occurred in FECV within a persistently infected cat allow it to acquire macrophage tropism and change the virus into the virulent FIPV 4 . Infections caused by the former show no clinically apparent or mild, self-limiting gastroenteritis in kittens. In contrast, FIPV infections develop high fatality and progressive, multi-systemic disorders in young cat populations. Feline infectious peritonitis remains one of the most devastating and lethal viral diseases among Felidae, not only because of the high mortality rate, but also because of the lack of effective options in diagnosis, prevention, and treatment 5 . The disease is further complicated by antibody-dependent enhancement (ADE), which can exacerbate disease symptoms 4 . Virus fusion with host cell endosomal membranes, facilitated by a low pH, is a major event for certain virus infection cascade 6 . Vacuolar ATPase (V-ATPase) activity, which is responsible for pumping protons into endosomal compartments, has been identified as a requirement for feline coronavirus replication in previous studies 7 . The endosomal acidification process is also necessary for the establishment of ADE in FIPV infection 8 . Therefore, the endosomal V-ATPase presents an attractive target for antiviral intervention. In the past decades, abundant studies indicated that V-ATPase inhibitors could be applied to treat viral infections as well as other diseases including osteoporosis, lytic bone disease, renal acidosis, and cancer 9,10 . For example, the most commonly used V-ATPase inhibitor, bafilomycin, showed a broad-spectrum antiviral effect against several pathogens. However, Published: xx xx xxxx OPEN www.nature.com/scientificreports/ 2 Scientific RepoRts | 7: 13043 | 
 Title: Nanoparticulate vacuolar ATPase blocker exhibits potent host- targeted antiviral activity against feline coronavirus OPEN
Example Output:
False