In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Q: C57 strain mice were inoculated intraperitoneally with denatured mouse hepatitis virus strain 3 particles and virus surface projection, membrane and ribonucleoprotein subeomponents, obtained from detergent treated purified virus preparations. All immunised animals developed high levels of serum antibody directed against the respective antigens, detectable by enzyme-linked immunosorbent assay. Mice that had been immunised with denatured virus particles or surface projections were protected against infection with mouse hepatitis virus strain 3, whereas immunisation with virus membrane or ribonucleoprotein subcomponents failed to protect mice against virus challenge.

A: Archives of Virology Antigenieity of Mouse Hepatitis Virus Strain 3 Subeomponents in C57 Strain Miee
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Q: Streptococcus pneumoniae is the main cause of diseases such as meningitis, pneumoniae and sepsis, especially in children and old people. Due to costly antibiotic treatment, and increasing resistance of pneumococcus, developing high-efficient protective vaccine against this pathogen is an urgent need. Although the pneumoniae polysaccharide vaccine (PPV) and pneumonia conjugate vaccines (PCV) are the efficient pneumococcal vaccine in children and adult groups, but the serotype replacement of S. pneumoniae strains causes the reduction in efficacy of such vaccines. For overcoming the aforesaid drawbacks epitope-based vaccines are introduced as the relevant alternative. In our previous research, the epitope vaccine was designed based on immunodominant epitopes from PspA, CbpA antigens as cellular stimulants and PhtD, PiuA as humoral stimulants. Because the low immunogenicity is the main disadvantage of epitope vaccine, in the current study, we applied coiled-coil selfassembled structures for developing our vaccine. Recently, self-assembled peptide nanoparticles (SAPNs) have gained much attention in the field of vaccine development due to their multivalency, self-adjuvanticity, biocompatibility, and size similarity to pathogen. In this regard, the final designed vaccine is comprised of cytotoxic T lymphocytes (CTL) epitopes from PspA and CbpA, helper T lymphocytes (HTL) epitopes from PhtD and PiuA, the pentamer and trimmer oligomeric domains form 5-stranded and 3-stranded coiled-coils as self-assembled scaffold, Diphtheria toxoids (DTD) as a universal T-helper, which fused to each other with appropriate linkers. The four different arrangements based on the order of above-mentioned compartments were constructed, and each of them were modeled, and validated to find the 3D structure. The structural, physicochemical, and immunoinformatics analyses of final vaccine construct represented that our vaccine could stimulate potent immune response against S. pneumoniae; however, the potency of that should be approved via various in vivo and in vitro immunological tests.

A: Designing self-assembled peptide nanovaccine against Streptococcus pneumoniae: An in silico strategy
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Q: A 26-year-old male with a past medical history of Crohn's disease, in remission for more than 10 years, presented to the Medical Intensive Care Unit (MICU) with diarrhea, hematuria, left-sided pulmonary infiltrates, transaminitis, and rapid-onset respiratory failure with acute kidney injury (AKI). The patient was well until 7 days prior to ICU admission, when he developed severe non-bloody diarrhea, approximately 20 times daily. Three days prior, he presented to an emergency department (ED) and was sent home after rehydration with normal saline with a reportedly normal chest x-ray (CXR). Two days prior, he presented to his primary care provider with continued diarrhea and fever to 39.4 °C, and he was sent home with anti-diarrheal medications. One day prior, he returned to the ED with chest tightness, shortness of breath, and cough productive of dark sputum, and he was found to have a new left-sided infiltrate on CXR, consistent with a pneumonia. He also reported dark urine and anorexia. He denied nausea, vomiting, abdominal pain, rash, or dysuria. In the ED, he was noted to be febrile with a temperature of 40.6 °C, tachycardic with a heart rate of 140 beats per minute, tachypneic with a respiratory rate of 29 breaths per minute and blood pressure of 115/65 mmHg, and hypoxic with an oxygen saturation of 93% on 4 L per minute of oxygen supplementation. He was transitioned to bilevel positive airway pressure (BIPAP) due to his increased work of breathing and hypoxia and received empiric antibiotic therapy and steroids, including intravenous (IV) ceftriaxone, azithromycin, and linezolid. He was then transferred to the University of Chicago Medicine MICU. His respiratory status worsened, and after about 5 h he was intubated. The patient had eaten no recent restaurant foods and had no known sick contacts. He worked as a pipe fitter. He denied having pets, unusual hobbies, or travel within the previous 6 months. On physical examination, his heart rate was 150 beats per minute, blood pressure 100/50 mmHg, temperature 39.1 °C, and respiratory rate 28 breaths per minute. He was intubated and sedated. He did not have any cervical adenopathy, and his conjunctivae were injected. His pulmonary exam demonstrated crackles bilaterally, and cardiovascular exam revealed a normal S1 and S2 with no murmurs. Pulses were equal, but capillary refill was slow, approximately 3 s. Abdominal exam showed normal liver and spleen to palpation and was nontender. He did not have any rashes. Initial serum laboratory results on transfer to the MICU included white blood cell (WBC) count of 11,900/μL (92% neutrophils, 3% lymphocytes), hemoglobin of 14.1 g/dL, and platelet count of 195,000/μL. The basic metabolic panel was within

A:
Diarrhea Leads to Pneumonia and Hematuria in the Intensive Care Unit
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