TASK DEFINITION: Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
PROBLEM: Context: Humans did not reach space until the second half of the 20th century. They needed somehow to break past Earths gravity. A rocket moves rapidly in one direction. The device is propelled by particles flying out of it at high speed in the other direction. There are records of the Chinese using rockets in war against the Mongols as early as the 13th century. The Mongols then used rockets to attack Eastern Europe. Early rockets were also used to launch fireworks. Rockets were used for centuries before anyone could explain how they worked. The theory came about in 1687. Isaac Newton (16431727) described three basic laws of motion, now referred to as Newtons Laws of Motion: 1. An object in motion will remain in motion unless acted upon by a force. 2. Force equals mass multiplied by acceleration. 3. To every action, there is an equal and opposite reaction. Which of these three best explains how a rocket works? Newtons third law of motion. When a rockets propulsion pushes in one direction, the rocket moves in the opposite direction, as seen in the Figure 23.12. For a long time, many people believed that a rocket wouldnt work in space. There would be nothing for the rocket to push against. But they do work! Fuel is ignited in a chamber. The gases in the chamber explode. The explosion creates pressure that forces the gases out of one side of the rocket. The rocket moves in the opposite direction, as shown in Figure 23.13. The force pushing the rocket is called thrust. For centuries, rockets were powered by gunpowder or other solid fuels. These rockets could travel only short distances. Around the turn of the 20th century, several breakthroughs took place. These breakthroughs led to rockets that could travel beyond Earth. Liquid fuel gave rockets enough power to escape Earths gravity (Figure 23.14). By using multiple stages, empty fuel containers could drop away. This reduced the mass of the rocket so that it could fly higher. Rockets were used during World War II. The V2 was the first human-made object to travel high enough to be considered in space (Figure 23.15). Its altitude was 176 km (109 miles) above Earths surface. Wernher von Braun was a German rocket scientist. After he fled Germany in WWII, he helped the United States develop missile weapons. After the war, von Braun worked for NASA. He designed the Saturn V rocket (Figure One of the first uses of rockets in space was to launch satellites. A satellite is an object that orbits a larger object. An orbit is a circular or elliptical path around an object. Natural objects in orbit are called natural satellites. The Moon is a natural satellite. Human-made objects in orbit are called artificial satellites. There are more and more artificial satellites orbiting Earth all the time. They all get into space using some sort of rocket. Why do satellites stay in orbit? Why dont they crash into Earth due to the planets gravity? Newtons law of universal gravitation describes what happens. Every object in the universe is attracted to every other object. Gravity makes an apple fall to the ground. Gravity also keeps you from floating away into the sky. Gravity holds the Moon in orbit around Earth. It keeps Earth in orbit around the Sun. Newton used an example to explain how gravity makes orbiting possible. Imagine a cannonball launched from a high mountain, as shown in Figure 23.17. If the cannonball is launched at a slow speed, it will fall back to Earth. This is shown as paths (A) and (B). Something different happens if the cannonball is launched at a fast speed. The Earth below curves away at the same rate that the cannonball falls. The cannonball then goes into a circular orbit, as in path (C). If the cannonball is launched even faster, it could go into an elliptical orbit (D). It might even leave Earths gravity and go into space (E). Unfortunately, Newtons idea would not work in real life. A cannonball launched at a fast speed from Mt. Everest would not go into orbit. 
 Question: The first rocket to travel into space was used during

SOLUTION: world war ii.

PROBLEM: Context: Spleen tyrosine kinase (SYK) has come into focus as a potential therapeutic target in chronic inflammatory diseases, such as rheumatoid arthritis and asthma, as well as in B-cell lymphomas. SYK has also been involved in the signaling of immunoreceptors, cytokine receptors, and integrins. We therefore hypothesized that inhibition of SYK attenuates the inflammatory process underlying atherosclerosis and reduces plaque development. Low-density lipoprotein receptor-deficient mice consuming a high-cholesterol diet supplemented with 2 doses of the orally available SYK inhibitor fostamatinib for 16 weeks showed a dose-dependent reduction in atherosclerotic lesion size by up to 596% compared with the respective controls. Lesions of fostamatinib-treated animals contained fewer macrophages but more smooth muscle cells and collagen-characteristics associated with more stable plaques in humans. Mechanistically, fostamatinib attenuated adhesion and migration of inflammatory cells and limited macrophage survival. Furthermore, fostamatinib normalized high-cholesterol diet -induced monocytosis and inflammatory gene expression. We present the novel finding that the SYK inhibitor fostamatinib attenuates atherogenesis in mice. Our data identify SYK inhibition as a potentially fruitful antiinflammatory therapeutic strategy in atherosclerosis. 
 Question: Which enzyme is inhibited by a drug fostamatinib?

SOLUTION: spleen tyrosine kinase

PROBLEM: Context: Peroxiredoxin 2 (Prx2) is an antioxidant enzyme that uses cysteine residues to decompose peroxides. Prx2 is the third most abundant protein in erythrocytes, and competes effectively with catalase and glutathione peroxidase to scavenge low levels of hydrogen peroxide, including that derived from hemoglobin autoxidation. Low thioredoxin reductase activity in the erythrocyte is able to keep up with this basal oxidation and maintain the Prx2 in its reduced form, but exposure to exogenous hydrogen peroxide causes accumulation of the disulfide-linked dimer. The high cellular concentration means that although turnover is slow, erythrocyte Prx2 can act as a noncatalytic scavenger of hydrogen peroxide and a sink for hydrogen peroxide before turnover becomes limiting. The consequences of Prx2 oxidation for the erythrocyte are not well characterized, but mice deficient in this protein develop severe hemolytic anemia associated with Heinz body formation. Prx2, also known as calpromotin, regulates ion transport by associating with the membrane and activating the Gardos channel. How Prx2 redox transformations are linked to membrane association and channel activation is yet to be established. In this review, we discuss the functional properties of Prx2 and its role as a major component of the erythrocyte antioxidant system. 
 Question: What type of enzyme is peroxiredoxin 2 (PRDX2)?

SOLUTION:
antioxidant