Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Mkuki na Nyota Publishers Ltd (MNP) is a book publishing company that was founded in 1991 in response to the general absence of independent scholarly publishing in Tanzania.

Answer: The year that Mkuki na Nyota was created was?


Question: The translocation (9;22) gives rise to the p190(Bcr-Abl) and p210(Bcr-Abl) tyrosine kinase proteins, considered sufficient for leukemic transformation. Philadelphia-positive (Ph(+)) acute leukemia patients failing to respond to initial induction therapy have a poor prognosis with few effective treatment options. Imatinib is an orally administered, potent inhibitor of the Bcr-Abl tyrosine kinase. We conducted a clinical trial in 56 patients with relapsed or refractory Ph(+) acute lymphoblastic leukemia (ALL; 48 patients) or chronic myelogenous leukemia in lymphoid blast crisis (LyBC; 8 patients). Imatinib was given once daily at 400 mg or 600 mg. Imatinib induced complete hematologic responses (CHRs) and complete marrow responses (marrow-CRs) in 29% of ALL patients (CHR, 19%; marrow-CR, 10%), which were sustained for at least 4 weeks in 6% of patients. Median estimated time to progression and overall survival for ALL patients were 2.2 and 4.9 months, respectively. CHRs were reported for 3 (38%) of the patients with LyBC (one sustained CHR). Grade 3 or 4 treatment-related nonhematologic toxicity was reported for 9% of patients; none of the patients discontinued therapy because of nonhematologic adverse reactions. Grade 4 neutropenia and thrombocytopenia occurred in 54% and 27% of patients, respectively. Imatinib therapy resulted in a clinically relevant hematologic response rate in relapsed or refractory Ph(+) acute lymphoid leukemia patients, but development of resistance and subsequent disease progression were rapid. Further studies are warranted to test the effects of imatinib in combination with other agents and to define the mechanisms of resistance to imatinib.

Answer: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Question: One day, a slave owner entered a local store and threatened a young boy who was his slave. At first, the slave refused to move and ran for the door. The slave owner reached for a heavy weight. He threw it at his slave. Instead, it hit Harriet on the head. Harriet almost died. For the rest of her life, she carried the mark of a deep wound on her head. Miser Brodas felt he never needed Harriet. He decided to sell her. Harriet thought of a way to prevent this. Each time she was shown to someone who might buy her, she acted as if she were falling asleep. After a while, Mister Brodas gave up the hope of selling Harriet. He sent her back to the fields. At 24 she married a free black man, John Tubman. By then, Harriet was sure she should escape. In 1849, Mister Brodas died. His slaves probably would be sold to further South. John Tubman tried to make Harriet forget about running away. Harriet decided she must end her marriage and that she needed to tell her family that she was leaving. Harriet escaped for Pennsylvania where slavery was banned there. Once she hid under hay that had been cut from the fields. Another time, she wore men's clothing. Finally, she arrived in Pennsylvania. Now that Harriet was free, she didn't forget other slaves in Maryland. During the next ten years, she freed her parents and other family members. She traveled back and forth eighteen times, helping about 300 slaves escape. She became an expert at hiding from slave hunters. At one time, anyone finding Harriet was promised 40,000dollars for catching her--dead or alive. The people she helped called her Moses. She had rescued them from slavery just as the biblical Moses rescued the Jews. After the Civil War began, Harriet started to spy for the North. She also served as a nurse. After four years of bloody fighting, the North won the war. Abraham Lincoln freed the slaves in 1863. There was no longer any need for Harriet to be Moses.

Answer:
We know from the passage that Harriet was Mister Brodas'    .