Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
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Question: Ulcer became worse after tobramycin and gentamycin treatment for 2 days.

Answer: adverse drug event


Question: Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitor.

Answer: adverse drug event


Question: In this article, four patient reports of a specific interaction--the serotonin syndrome--are presented.

Answer:
non-adverse drug event