Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Possible relationships between the white matter lesions and extrinsic toxic agents are discussed.
non-adverse drug event

There was no evidence of recurrent myeloma after the initial remission on cyclophosphamide therapy.
non-adverse drug event

A 77-year-old man developed ankle, hand, and facial swelling 2 weeks after starting rosiglitazone.

adverse drug event