Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: It is unanimously accepted that there is an unmet need for pain medications that are both effective and safe. Unfortunately, no really novel analgesics have been approved over the past three decades. In view of both experimental and clinical evidence of a major role for nerve growth factor (NGF) in the generation and maintenance of a wide range of pain states, drug discovery efforts focusing on the development of anti-NGF agents have aroused particular interest. Several humanized anti-NGF monoclonal antibodies (mAbs) have entered clinical trials as potential analgesics. In this respect, tanezumab is at an advanced stage of clinical development while fulranumab, fasinumab and ABT-110, previously known as PG110, are in early phases of clinical development. This Current Opinion article aims at describing the rationale for targeting NGF for pain, reviewing the analgesic efficacy and safety of anti-NGF agents based on data from fully published studies, conference abstracts, and the US Food and Drug Administration (FDA) website, and discussing the possible future of these agents in managing chronic pain. Anti-NGF mAbs produced significant pain relief and functional improvement in patients with osteoarthritis of the knee and/or hip. Conversely, studies in non-specific lower back pain generated mixed results; overall, this condition appeared to be less responsive to anti-NGF agents than osteoarthritis. Finally, there was no conclusive evidence of the effectiveness of anti-NGF mAbs in some types of chronic visceral or neuropathic pain. Furthermore, these studies raised safety concerns about anti-NGF mAbs. As a class, these drugs may cause or worsen peripheral neuropathies. But the most problematic issue-which prompted the FDA to place studies of these compounds on clinical hold in 2010-was rapid joint destruction leading to joint replacement surgery. The aetiologies of these side effects have been much debated and their pathophysiology is poorly understood. After an Arthritis Advisory Committee meeting held in March 2012, pharmaceutical companies negotiated with the FDA on the conditions for restarting clinical studies. Although the FDA lifted its clinical hold, there remain many unresolved issues about the long-term efficacy and safety of anti-NGF mAbs. While acknowledging that the future of these drugs is unforeseeable, it appears that they may not be the safe and effective painkillers that have been awaited for decades.

Output: What is the target of tanezumab?


Input: Consider Input: If you are a high school senior graduating and looking to enter college in 2006, you will take the new exam. The biggest change to the SAT will be the introduction of a new writing section. The writing section will consist of two parts: an essay and a multiple-choice section. Students will be given 25 minutes to respond to a prompt and construct a well-organized essay that effectively deals with the task. The essay question may require students to complete a statement, to react to a quote, or to agree or disagree with a point of view. In any case, a good essay will support the chosen position with specific reasons and examples from literature, history, art, science, current affairs, or even a student's own experiences. Essays will be scored based on the procedures for the current SAT II: Writing Test. Essays will be graded by two independent readers On a scale of 1~6, and their two scores will be combined to form an essay subscore that ranges from 2 to 12. Should the readers' scores vary by more than 2 points, a third reader will score the essay; The readers will be high school teachers and college professors who teach composition. To ensure that essays will be scored in a timely manner, they will be scanned and made available to readers on the Internet for grading purpose. The writing section will also include multiple-choice grammar and usage questions. Some of these questions will call upon students to improve given sentences and paragraphs. Others will present students with sentences and require them to identify mistakes in diction , grammar, sentence construction, subject-verb agreement, proper word usage. The highest possible score on the new writing section will be 800. Scores on the essay and multiple-choice section will be combined to produce a single score. A writing subscore will also be assigned. The highest possible scores on the Critical Reading and Math sections will remain 800 each, making 2,400 a perfect score on the new SAT.

Output: Which parts are included in the writing section of SAT according to the passage?


Input: Consider Input: On April 20,2013, a big and powerful earthquake attacked Ya'an, Sichuan Province. A great many buildings and houses _ a lot of people were killed and even more people lost their homes in the earthquake . Death toll from the 7.0-magnitude earthquake that hit Ya'an in southwestern China's Sichuan Province has risen to 188 (as of 18:00 pm, April 22, ), according to latest calculations by local Civil Affairs Bureau. At least 11,826 were reportedly injured in the quake while 25 are still missing, the bureau said. Experts are anticipating much less casualties in the quake than that from the 8.0 magnitude quake hit Wenchuan on May 12, 2008, also in Sichuan Province, which killed more than 80,000 and injured over 300,000. Energy released from Wenchuan earthquake would be 30 times of that from Ya'an quake, according to Zhang Xiaonan, an expert with China's Geophysical Union. Dai Junwu with Harbin-based seismological bureau expects the death toll at less than 1,000, and economic losses from the quake could reach up to 100 billion yuan. Police and expert teams have already rushed for rescue in the quick stricken areas, and the State Council has banned unauthorized rescue efforts and individual vehicles from going to the quake zone to avoid congestion . Rescue efforts were carried "timely and orderly", said Chinese Premier Li Keqiang who flew to the quicken-stricken area on Sunday, the second day of the quake. He was quoted as saying that "the current priority is to save lives".


Output: When did Ya'an earthquake occur?