In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

[Q]: The high mutation rate of the human immunodeficiency virus type 1 (HIV-1) virus is a major problem since it evades the function of antibodies and chemical inhibitors. Here, we demonstrate a viral detection strategy based on synthetic biology principles to detect a specific viral function rather than a particular viral protein. The resistance caused by mutations can be circumvented since the mutations that cause the loss of function also incapacitate the virus. Many pathogens encode proteases that are essential for their replication and that have a defined substrate specificity. A genetically encoded sensor composed of a fused membrane anchor, viral protease target site, and an orthogonal transcriptional activator was engineered into a human cell line. The HIV-1 protease released the transcriptional activator from the membrane, thereby inducing transcription of the selected genes. The device was still strongly activated by clinically relevant protease mutants that are resistant to protease inhibitors. In the future, a similar principle could be applied to detect also other pathogens and functions.
[A]: Function-Based Mutation-Resistant Synthetic Signaling Device Activated by HIV-1 Proteolysis


[Q]: 2 The abbreviations used are: S, spike; SARS-CoV, severe acute respiratory syndrome coronavirus; MLV, murine leukemia virus; DC-SIGN, dendritic cell-specific intercellular adhesion molecule-3-gubbing non-integrin, ACE2, argiotensin I conserting enzyme 2. FIGURE 4. Introduction of alanine residues in the S2 region modulates elastase-induced virus entry mediated by SARS-CoV S. A and B, pseudotyped virion infections were performed as described for Fig. 2. Infection was induced by treatment with elastase (A) or trypsin (B). Results are presented as relative light units (RLU). Error bars represent the S.E. of three independent experiments. C, cleavage of SARS-CoV by elastase. HEK293T cells expressing the wild type (WT) or mutant SARS-CoV spike protein were treated with 50 g/ml elastase. Cell surface proteins were biotinylated and precipitated, and cleavage products of the SARS-CoV spike protein were analyzed in Western blot with an antibody recognizing the C9 tag at the C terminus of the protein.
[A]: Elastase-mediated Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein at Discrete Sites within the S2 Domain * □ S


[Q]: Traditionally, most of the proposed probabilistic models of decision under uncertainty rely on numerical measures and representations. Alternative proposals call for qualitative (non-numerical) treatment of uncertainty, based on preference relations and belief orders. The automation of both numerical and non-numerical frameworks surely represents a preliminary step in the development of inference engines of intelligent agents, expert systems, and decision-support tools. In this paper we exploit Answer Set Programming to formalize and reason about uncertainty expressed as belief orders. The availability of ASP-solvers supports the design of automated tools to handle such formalizations. Our proposal reveals particularly suitable whenever the domain of discernment is partial. We first illustrate how to automatically "classify ^^, according to the most well-known uncertainty frameworks, any given qualitative uncertainty assessment. Then, we show how to compute an enlargement of the assessment, to any other new inference target.
[A]:
Management of uncertainty orderings through ASP