instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: The selective degradation of cytosolic proteins in lysosomes by chaperone-mediated autophagy depends, at least in part, on the levels of a substrate receptor at the lysosomal membrane. We have previously identified this receptor as the lysosome-associated membrane protein type 2a (lamp2a) and showed that levels of lamp2a at the lysosomal membrane directly correlate with the activity of the proteolytic pathway. Here we show that levels of lamp2a at the lysosomal membrane are mainly controlled by changes in its half-life and its distribution between the lysosomal membrane and the matrix. The lysosomal degradation of lamp2a requires the combined action of at least two different proteolytic activities at the lysosomal membrane. Lamp2a is released from the membrane by the action of these proteases, and then the truncated lamp2a is rapidly degraded within the lysosomal matrix. Membrane degradation of lamp2a is a regulated process that is inhibited in the presence of substrates for chaperone-mediated autophagy and under conditions that activate that type of autophagy. Uptake of substrate proteins also results in transport of some intact lamp2a from the lysosomal membrane into the matrix. This fraction of lamp2a can be reinserted back into the lysosomal membrane. The traffic of lamp2a through the lysosomal matrix is not mediated by vesicles, and lamp2a reinsertion requires the lysosomal membrane potential and protein components of the lysosomal membrane. The distribution of lamp2a between the lysosomal membrane and matrix is a dynamic process that contributes to the regulation of lysosomal membrane levels of lamp2a and consequently to the activity of the chaperone-mediated autophagic pathway. 
 Question: Which is the receptor for substrates of Chaperone Mediated Autophagy?
answer:
lamp2a


question:
Context: The Jack Sport was a French automobile manufactured from 1925 until 1930. 
 Question: What year was the end of Jack Sport?
answer:
1930


question:
Context: The War of the Spanish Succession ended with the Treaty of Utrecht in 1713. The colonial borders of northeastern North America were reshaped as a result, but the treaty did not account for Indian claims to the same area. French Acadia was ceded to Great Britain which established the province of Nova Scotia, although its borders were disputed. The area disputed by the European powers consisted of land between the Kennebec River and the Isthmus of Chignecto . This land was occupied by a number of Algonquian-speaking Indian tribes loosely allied in the Wabanaki Confederacy, which also claimed sovereignty over most of this territory and had occupancy preceding that of the Colonists. Massachusetts Governor Joseph Dudley organized a major peace conference at Portsmouth, New Hampshire. In negotiations there and at Casco Bay, the Wabanaki present orally objected to British assertions that the French had ceded their territory to Britain in eastern Maine and New Brunswick, and agreed to a confirmation of boundaries at the Kennebec River and the establishment of government-run trading posts in their territory.:162-163 The Treaty of Portsmouth was ratified on July 13, 1713 by eight representatives of the Wabanaki Confederacy, however, which asserted British sovereignty over their territory.:107-110 Over the next year, other Abenaki tribal leaders also signed the treaty, but no Mi'kmaq ever signed it or any other treaty until 1726.:97-98 
 Question: Which treaty established Nova Acotia?
answer:

treaty of utrecht