Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Q: Context: Lever House, designed by Gordon Bunshaft and Natalie de Blois (design coordinator) of Skidmore, Owings and Merrill and located at 390 Park Avenue in Midtown Manhattan, New York City, is a seminal glass-box skyscraper built in the International Style according to the design principles of Ludwig Mies van der Rohe. 
 Question: Who was the architect or designer of Lever House?

A: gordon bunshaft
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Q: Context: Louis Philippe I (6 October 1773 -- 26 August 1850) was King of the French from 1830 to 1848 as the leader of the Orleanist party. 
 Question: What nationality was Louis Philippe I?

A: french
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Q: Context: The phagocyte NADPH oxidase is dormant in resting cells but becomes activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants, thereby playing a crucial role in host defence. The catalytic core of this enzyme comprises the two membranous subunits gp91phox/Nox2 and p22phox. The oxidase activation requires the small GTPase Rac and the SH3 domain-containing proteins p47phox and p67phox; they normally exist in the cytoplasm and translocate upon cell stimulation to the membrane. The translocation depends on a stimulus-induced conformational change of p47phox, which leads to the SH3 domain-mediated interaction with p22phox, a binding required for the gp91phox/Nox2-dependent superoxide production. Activation of Nox1, an oxidase that is likely involved in host defence at the colon, requires novel proteins homologous to p47phox and p67phox, designated Noxo1 and Noxa1, respectively. Noxo1 and Noxa1, both expressed abundantly in the colon, are capable of constitutively activating Nox1. The constitutive activation may be due to the property of Noxo1: in contrast with p47phox, Noxo1 seems to normally associate with p22phox, which is required for the Nox1 activation. We will also describe the mechanism underlying regulation of the third oxidase Nox3, which exits in fetal kidney and inner ears. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?

A:
nadph oxidase 1
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