Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

Example Input: In prokaryotes, a(n) genome is composed of a single, double-stranded dna molecule in the form of a loop or circle.
Example Output: In prokaryotes, what is composed of a single, double-stranded dna molecule in the form of a loop or circle?

Example Input: In machines that increase force, such as ramps and doorknobs and nutcrackers, output is greater is the relation between output and input force.
Example Output: In machines that increase force, such as ramps and doorknobs and nutcrackers, what is the relation between output and input force?

Example Input: Addiction affects the dopamine receptors within the brain.
Example Output:
Addiction affects what type of chemical receptors within the brain?