instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia chromosome, which is associated with a balanced translocation involving chromosomes 9 and 22 to produce a fusion gene (bcr-abl) that gives rise to a constitutively activated Abl tyrosine kinase. This kinase led to the discovery of several small-molecule inhibitors, imatinib being the first and most successful of these. Resistance to imatinib results in some patients from Abl kinase point mutations. Overcoming imatinib resistance represents one of the biggest challenges facing clinicians in the modern management of CML. In this review, we discuss the current understanding of CML pathophysiology and mechanisms of imatinib resistance and how advancing this knowledge has led to the design of novel therapies in the area of blastic phase CML and Philadelphia chromosome-positive acute lymphoblastic leukemia with previous imatinib failure. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
answer:
bcr-abl


question:
Context: Ceraunius Tholus is a volcano on Mars located in the Tharsis quadrangle at 24.25 north latitude and 262.75 east longitude, part of the Uranius group of volcanoes. 
 Question: On what moon or planet can Ceraunius Tholus be found?
answer:
mars


question:
Context: Superfast doubledecker trains will be taking passengers from London to six big cities in the UK by 2033. The first phase linking London to the West Midlands with a connection to HS1 is expected to open in 2026, and the second phase to Manchester and Leeds in 2032. The government set out a plan for the highspeed rail network in 2012. When the project is finished, it will take less time to get to London from major cities like Birmingham, Manchester and Leeds. Traveling at a speed of up to 250 mph, passengers will be able to come and go from Birmingham to London in 49 minutes, reducing the journey time by almost half from one hour and 24 minutes. A journey from Birmingham to Leeds will be reduced from two hours to 57 minutes and a journey from Manchester to London will be reduced from two hours and 8 minutes to one hour and 8 minutes. "HS2 is an important part of transport's lowcarbon future," Transport Secretary Justine Greening said. Some people aren't happy about the plan, though. HS2 will cost around PS33 billion. It will also be built near some towns and villages, disturbing the people that live there. But the Chancellor of the Exchequer George Osborne thinks it will help build the future for Britain. "It's a longterm decision," he said. HS2 is designed for everything around the needs of the passengers. It will provide a new and exciting travel experience. There will be plenty of room, intelligent ticketing, a good service and high quality comfort and access to trains. This is a transport network for the new century and beyond. 
 Question: How long does it usually take you to travel from Birmingham to London by the ordinary train?
answer:

one hour and 24 minutes.