instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: Mutations in the solute carrier family 9, subfamily A member 6 (SLC9A6) gene, encoding the endosomal Na+/H+ exchanger 6 (NHE6) are associated with Christianson syndrome, a syndromic form of X-linked intellectual disability characterized by microcephaly, severe global developmental delay, autistic behavior, early onset seizures and ataxia. In a 7-year-old boy with characteristic clinical and neuroimaging features of Christianson syndrome and epileptic encephalopathy with continuous spikes and waves during sleep, we identified a novel splice site mutation (IVS10-1G>A) in SLC9A6. These findings expand the clinical spectrum of the syndrome and indicate NHE6 dysfunction as a new cause of electrical status epilepticus during slow-wave sleep (ESES). 
 Question: Mutation of which gene is implicated in the Christianson syndrome?
answer:
slc9a6


question:
Context: Sven Gerich The information up to 2007 was retrieved from Die Wiesbadener Oberburgermeister seit dem Bau des neuen Rathauses (1886) (The Wiesbaden Mayors since the construction of the new town mayor hall (1886) ) 
 Question: Who became the leader of Wiesbaden?
answer:
sven gerich


question:
Context: Parkinson's disease is the most common neurodegenerative movement disorder. -Synuclein is a small synaptic protein that has been linked to familial Parkinson's disease (PD) and is also the primary component of Lewy bodies, the hallmark neuropathology found in the brain of sporadic and familial PD patients. The function of -synuclein is currently unknown, although it has been implicated in the regulation of synaptic vesicle localization or fusion. Recently, overexpression of -synuclein was shown to cause cytoplasmic vesicle accumulation in a yeast model of -synuclein toxicity, but the exact role -synuclein played in mediating this vesicle aggregation is unclear. Here, we show that -synuclein induces aggregation of many yeast Rab GTPase proteins, that -synuclein aggregation is enhanced in yeast mutants that produce high levels of acidic phospholipids, and that -synuclein colocalizes with yeast membranes that are enriched for phosphatidic acid. Significantly, we demonstrate that -synuclein expression induces vulnerability to perturbations of Ypt6 and other proteins involved in retrograde endosome-Golgi transport, linking a specific trafficking defect to -synuclein phospholipid binding. These data suggest new pathogenic mechanisms for -synuclein neurotoxicity. 
 Question: Which is the primary protein component of Lewy bodies?
answer:

αsyn