Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: The Van Gogh Museum's Wheatfield with Crows was painted in July 1890, in the last weeks of van Gogh's life.

Output: What is the name of the place where Wheatfield with Crows can be found?


Input: Consider Input: The aim of this study was to elucidate the role of lysyl oxidase (LOX) and lysyl oxidase like (LOXL) 2 in pathologic wound healing after glaucoma surgery. We therefore investigated the expression of LOX and LOXL2 and evaluated the therapeutic potential of anti-LOX (GS-639556, formerly M64) and anti-LOXL2 (GS-607601, formerly AB0023) antibodies in a rabbit model of glaucoma trabeculectomy. Ocular expression of LOX and LOXL2 was investigated by immunohistologic staining at different time points after trabeculectomy. Treatment with GS-639556 or GS-607601 was initiated in rabbits immediately after trabeculectomy by giving both intracameral and subconjunctival injections. Thereafter, the antibodies were given twice a week subconjunctivally until day 30 after surgery (day of euthanization). Treatment outcome was studied by clinical investigation of the bleb and by immunohistochemical analysis of angiogenesis, inflammation, and collagen deposition. LOX and LOXL2 were both upregulated in Tenon's capsule and the conjunctiva after glaucoma surgery. Repeated administration of LOX- or LOXL2-targeting monoclonal antibodies increased bleb area and bleb survival. Analyses of immunohistologic stainings showed that both antibodies significantly decreased fibrosis, whereas the anti-LOXL2 antibody also significantly reduced blood vessel density and inflammation. Targeting LOXL2 with an inhibitory monoclonal antibody (GS-607601) reduced pathologic angiogenesis, inflammation, and fibrosis. These results suggest that LOXL2 could be an appealing target for treatment of scar formation after glaucoma surgery, and point to the potential therapeutic benefits of simtuzumab, a humanized monoclonal antibody derived from GS-607601.

Output: What is the drug target for Simtuzumab?


Input: Consider Input: Most musicians agree that the best violins were made in Cremona, Italy, about 200 years ago. They even sound better than violins made today. Violin makers and scientists try to make instruments like the old Italian violins. But they aren't the same. Why are these old Italian violins so special? Many people think they have an answer. Some people think it is the age of the violins. But there is a problem here. Not all old violins sound wonderful. Only those from Cremona are special. So age cannot be the answer. Other people think the secret to those violins is the wood. The wood of the violin is very important. It must be from certain kinds of trees. It must not be too young or too old. Perhaps the violin makers of Cremona knew something special about wood for violins. But the kind of wood may not be so important. It may be more important to cut the wood in a special way. Wood for a violin must be cut very carefully. It has to be the right size and shape. The smallest difference will change the sound of the violin. Musicians sometimes think that this is the secret of the Italians. Size and shape may not be the answer either. Scientists make new violins that are exactly the same size and shape. But the new violins still do not sound as good as the old one. Some scientists think the secret may be the varnish , which covers the wood of the violin and makes it look shiny. It also helps the sound of the instrument. Since no one knows what the Italian violin makers used in their varnish, no one can make the same varnish today. There may never be other violins like the violins of Cremona. And there are not many of the old violins left. So these old violins are becoming more and more precious.


Output: What is still unclear about Cremona violins according to the writer?