Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

[EX Q]: Context: Ca2+ is a ubiquitous intracellular messenger responsible for controlling numerous cellular processes including fertilization, mitosis, neuronal transmission, contraction and relaxation of muscles, gene transcription, and cell death. At rest, the cytoplasmic Ca2+ concentration [Ca2+]i is approximately 100 nM, but this level rises to 500-1,000 nM upon activation. In osteoblasts, the elevation of [Ca2+]i is a result of an increase in the release of Ca2+ from endoplasmic reticulum and/or extracellular Ca2+ influx through voltage gated Ca2+ channels. Many of the cellular effects of Ca2+ are mediated by the Ca2+ binding protein, calmodulin (CaM). Upon binding up to four calcium ions, CaM undergoes a conformational change, which enables it to bind to specific proteins eliciting a specific response. Calmodulin kinase II (CaMKII) is a major target of the Ca(2+)/CaM second messenger system. Once bound to Ca(2+)/CaM, the multimeric CaMKII is released from its autoinhibitory status and maximally activated, which then leads to an intraholoenzyme autophosphorylation reaction. Calcineurin (Cn) is another major target protein that is activated by Ca(2+)/CaM. Cn is a serine-threonine phosphatase that consists of a heterodimeric protein complex composed of a catalytic subunit (CnA) and a regulatory subunit (CnB). Upon activation, Cn directly binds to, and dephosphorylates nuclear factor of activated T cells (NFAT) transcription factors within the cytoplasm allowing them to translocate to the nucleus and participate in the regulation of gene expression. This review will examine the potential mechanisms by which calcium, CaM, CaMKII, and Cn/NFAT control osteoblast proliferation and differentiation. 
 Question: Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)?
[EX A]: can

[EX Q]: Context: Bazex syndrome, or acrokeratosis paraneoplastica, is a cutaneous paraneoplastic syndrome characterized by psoriasiform lesions associated with, usually, a squamous cell carcinoma of the upper aerodigestive tract. We present a case of Bazex syndrome associated with metastatic cervical squamous cell carcinoma with an unknown primary. The features of the condition are discussed in the light of current knowledge. 
 Question: Name synonym of Acrokeratosis paraneoplastica.
[EX A]: bazex syndrome

[EX Q]: Context: One day, a brave jackal came to the river to drink some water. He saw a lion looking weak and tired, and asked, "What is the matter, King of the Jungle?" The lion told the jackal his story. The jackal felt sorry for the lion. He pulled and pulled at the lion's tail until the lion became free. The lion was very happy and said, "Thank you so much for helping me. I thought I would die! You are my friend for life! I would like you to come and live with me. From now on, I will hunt and share my food with you." The jackal moved in with the lion's family and had a wonderful time. Soon, the lion had children of his own and so did the jackal. The lioness was not happy about the friendship. She complained to her children. Her children complained to the jackal's children; the jackal's children complained to their mother and their mother complained to the jackal. The jackal was upset and told the lion, "You told me to live with you. If you don't like it any more, you should have said so yourself." The lion was shocked and said, "This is not true. I've never complained about you. I still want you to continue staying with me." The jackal said, "We understand each other. But our families don't. Perhaps it is better for us to live apart, but continue meeting each other when we are free. We can even hunt together!" The two families parted, but the lion and the jackal met often and remained friends for the rest of their lives. From the above paragraphs, we can conclude that in order to keep our good friendship, we have to give something up or give in in some particular cases. However, we can never give up or destroy our families. What do you think of it? 
 Question: How was the lion when the jackal first met him?
[EX A]:
weak and tired.