instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: The observations that Lymphopenia is common in severe acute respiratory syndrome (SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by SARS-CoV indicate that PBMC could be useful in identifying the gene expression profile in convalescent patients and tracing the host response to SARS-CoV infection. In this study, the altered genes expressions in the PBMC of convalescent SARS patients were investigated with suppression subtractive hybridization (SSH). We found that genes encoded by mitochondrial DNA (mtDNA) were obviously upregulated, while mitochondria were now found to be closely connected with antiviral immunity. The identification of a viral gene, M, in SSH cDNA library shows the long-term existence of SARS-CoV in vivo. In addition, some oxidative stress sensitive genes, heat shock proteins, transcription factors, and cytokines showed remarkable elevation. Thin-section electron microscope shows increased lysosome-like granule and mitochondria in PBMC of patients. These results provide important intracellular clue for tracing host response to SARS-CoV infection and suggest a role of mitochondria in that process. 
 Title: Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients
answer:
True


question:
Paragraph: Background: Porcine epidemic diarrhea virus (PEDV) is emerging as a pathogenic coronavirus that causes a huge economic burden to the swine industry. Interaction of the viral spike (S) surface glycoprotein with the host cell receptor is recognized as the first step of infection and is the main determinant of virus tropism. The mechanisms by which neutralizing antibodies inhibit PEDV have not been defined. Isolating PEDV neutralizing antibodies are crucial to identifying the receptor-binding domains of the viral spike and elucidating the mechanism of protection against PEDV infection. Methods: B cell hybridoma technique was used to generate hybridoma cells that secrete specific antibodies. E.coli prokaryotic expression system and Bac-to-Bac expression system were used to identify the target protein of each monoclonal antibody. qPCR was performed to analyze PEDV binding to Vero E6 cells with neutralizing antibody. Results: We identified 10 monoclonal antibodies using hybridoma technology. Remarkably, 4 mAbs (designed 2G8, 2B11, 3D9, 1E3) neutralized virus infection potently, of which 2B11 and 1E3 targeted the conformational epitope of the PEDV S protein. qPCR results showed that both 2B11 and 2G8 blocked virus entry into Vero cells. Conclusion: The data suggested that PEDV neutralizing antibody inhibited virus infection by binding to infectious virions, which could work as a tool to find the receptor-binding domains. 
 Title: Neutralizing antibodies against porcine epidemic diarrhea virus block virus attachment and internalization
answer:
False


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Paragraph: Literature review shows that little research has done so far to estimate how tourism indicators are affected by new High Speed Rail (HSR) lines. In 2012, a multivariate panel analysis developed by Chen and Haynes was applied to the Chinese regions to quantify the HSR impact on tourism output. The Chinese experience confirmed that, during the period 1999-2010, emerging high speed rail services did have significant positive impacts on boosting tourism in China. Since them, no similar empirical tool has ever been tested in Europe. The aim of this paper is to analyze and validate the suitability of this tool to assess empirically the effects of HSR on Spanish tourism during the period 1999-2014, and to enhance the abovementioned model with a tourism database. With more than 20 years' HSR experience, and operating the longest HSR network in Europe (2,900 km), Spain offers a good scenario for this model application because Spanish tourism sector represents 10.2% of its gross domestic product (GDP). Results clearly show that there is a direct linkage between the evolution of certain Spanish tourism outputs and the construction of the HSR network. However, authors´ recommendations include future new research on some variables limitations like the type of tourism output considered or the consideration of alternative explanatory indicators. 
 Title: ScienceDirect The assessment of the HSR impacts on Spanish tourism: an approach based on multivariate panel data analysis-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of the organizing committee of CIT 2016
answer:

True