In this task you will be given a text passage from a trivia quiz. You should choose the category this question belongs to from these categories: History, Science, Social Science, Fine Arts, Literature. You can only choose one category, so if in doubt, please choose the closest match.

[EX Q]: One disorder involving this organelle is caused by a mutation in E325K on the NAGA gene, called Schindler disease. One method of transporting molecules to it involves an hsc70-containing chaperone complex. Another disorder results in enzyme transport to the extracellular space rather than this organelle and is called I-cell disease. Proteins are marked for this structure with mannose-6-phosphate, and proton pump activity in this organelle maintains the acidic pH necessary for its primary function. One genetic defect results in ganglioside buildup in this organelle and thus causes Tay-Sachs disease. For 10 points, identify this cellular organelle that breaks down macromolecules with the aid of acid hydrolases.
[EX A]: Science

[EX Q]: The oxidation of one of these compounds with a Jones reagent yields carboxylic acid, and they are the product of the reaction of a ketone with a Grignard reagent. Esters are formed via a reaction of carboxylic acid and this compound in a process named for Fischer. Consisting of a hydroxyl group bonded to a carbon atom, they are given the formula R-OH. For 10 points, name this class of compounds exemplified by methanol and ethanol, the latter of which is found in hand sanitizer and beer.
[EX A]: Science

[EX Q]: The opinion on this case asked whether it could be classified as an instance of damnum absque injuria, and the Chief Justice wrote that "the Government of the United States has been emphatically termed a government of laws, and not of men." William Cushing and Alfred Moore did not take part in the ruling on this case, which found, in part, that the Supreme Court does not have the (*) original jurisdiction to issue writs of mandamus. The namesake of this case had been appointed justice of the peace in the District of Columbia, as one of John Adams' "Midnight Judges." It declared a clause of the Judiciary Act of 1789 unconstitutional, making it the first piece of legislation to be overturned by the Supreme Court. FTP, name this 1803 Supreme Court case which established the concept of judicial review.
[EX A]:
Social Science