TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Does cYP3A5 genotype influence everolimus in vitro metabolism and clinical pharmacokinetics in renal transplant recipients?
Answer: This study provides direct and indirect evidence that CYP3A5 genotyping cannot help improve everolimus therapy.

SOLUTION: no

PROBLEM: Question: Do interictal epileptiform discharges have an independent association with cognitive impairment in children with lesional epilepsy?
Answer: Overall, IED effects on cognition were of a magnitude similar to lesional influences or drug effects (topiramate use). This study demonstrates an association between IEDs and cognitive dysfunction, independent of the underlying focal brain pathology.

SOLUTION: yes

PROBLEM: Question: Does repeated freezing and thawing generally alter assay results for several commonly studied reproductive hormones?
Answer: There is no consistent or predictable alteration in the results of SHBG, or the glycoprotein and steroid hormones evaluated, as a function of repeated freeze/thaw or the storage temperature of human serum.

SOLUTION:
no