Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: ZFHX1B encodes Smad-interacting protein 1, a transcriptional corepressor involved in the transforming growth factors beta (TGFbeta) signaling pathway. ZFHX1B mutations cause a complex developmental phenotype characterized by severe mental retardation (MR) and multiple congenital defects. We compared the distribution of ZFHX1B transcripts during mouse and human embryogenesis as well as in adult mice and humans. This showed that this gene is strongly transcribed at an early stage in the developing peripheral and central nervous systems of both mice and humans, in all neuronal regions of the brains of 25-week human fetuses and adult mice, and at varying levels in numerous nonneural tissues. Northern blot analysis suggested that ZFHX1B undergoes tissue-specific alternative splicing in both species. These results strongly suggest that ZFHX1B determines the transcriptional levels of target genes in various tissues through the combinatorial interactions of its isoforms with different Smad proteins. Thus, as well as causing neural defects, ZFHX1B mutations may also cause other malformations.
[EX A]: Which gene is responsible for the development of the Mowat-Wilson syndrome?

[EX Q]: The Jinfeng Gold Mine (Chinese: ) is an combined open pit and underground gold mining operation in the Guizhou province, China.
[EX A]: The product of Jinfeng Gold Mine is what?

[EX Q]: The Fiji crested iguana or Fijian crested iguana (Brachylophus vitiensis) is a critically endangered species of iguana native to some of the northwestern islands of the Fijiian archipelago, where it is found in dry forest.
[EX A]:
What is the conservation status of Fiji crested iguana?