Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Q: Context: Telomeres may regulate human disease by at least two independent mechanisms. First, replicative senescence occurs once short telomeres generate DNA-damage signals that produce a barrier to tumor progression. Second, telomere position effects (TPE) could change gene expression at intermediate telomere lengths in cultured human cells. Here we report that telomere length may contribute to the pathogenesis of facioscapulohumeral muscular dystrophy (FSHD). FSHD is a late-onset disease genetically residing only 25-60 kilobases from the end of chromosome 4q. We used a floxable telomerase to generate isogenic clones with different telomere lengths from affected patients and their unaffected siblings. DUX4, the primary candidate for FSHD pathogenesis, is upregulated over ten-fold in FSHD myoblasts and myotubes with short telomeres, and its expression is inversely proportional to telomere length. FSHD may be the first known human disease in which TPE contributes to age-related phenotype. 
 Question: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?

A: fshd
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Q: Context: Lets explore the domain, the least specific category of classification. All of life can be divided into three domains, based on the type of cell of the organism: 1. Bacteria: cells do not contain a nucleus. 2. Archaea: cells do not contain a nucleus; they have a different cell wall from bacteria. 3. Eukarya: cells do contain a nucleus. The Archaea and Bacteria domains ( Figure 1.1) are both entirely composed of small, single-celled organisms and seem very similar, but they also have significant differences. Both are composed of prokaryotic cells, which are cells without a nucleus. In addition, both domains are composed of species that reproduce asexually ( asexual reproduction) by dividing in two. Both domains also have species with cells surrounded by a cell wall, however, the cell walls are made of different materials. Bacterial cell walls contain the polysaccharide peptidoglycan. Lastly, Archaea often live in extreme environments including hot springs, geysers, and salt flats. Bacteria do not live in these environments. The Group A Streptococcus organism (left) is in the domain Bacteria, one of the three domains of life. The Halobacterium (right) is in the domain Archaea, another one of the three domains. All of the cells in the domain Eukarya keep their genetic material, or DNA, inside the nucleus. The domain Eukarya is made up of four kingdoms: 1. Plantae: Plants, such as trees and grasses, survive by capturing energy from the sun, a process called photo- synthesis. 2. Fungi: Fungi, such as mushrooms and molds, survive by "eating" other organisms or the remains of other organisms. These organisms absorb their nutrients from other organisms. 3. Animalia: Animals also survive by eating other organisms or the remains of other organisms. Animals range from tiny ants to the largest whales, and include arthropods, fish, amphibians, reptiles, and mammals ( Figure 4. Protista: Protists are not all descended from a single common ancestor in the way that plants, animals, and fungi are. Protists are all the eukaryotic organisms that do not fit into one of the other three kingdoms. They include many kinds of microscopic one-celled (unicellular) organisms, such as algae and plankton, but also giant seaweeds that can grow to be 200 feet long. Plants, animals, fungi, and protists might seem very different, but remember that if you look through a microscope, you will find similar cells with a membrane-bound nucleus in all of them. These are eukaryotic cells. These cells also have membrane-bound organelles, which prokaryotic cells lack. The main characteristics of the three domains of life are summarized in Table 1.1. Multicelluar Cell wall Nucleus (Membrane- Enclosed DNA) Membrane-Bound Organelles Archaea No Yes, without peptidogly- can Bacteria No Yes, with peptidoglycan No No Eukarya Yes Varies. Plants and fungi have a cell wall; animals do not. Yes No No Yes Diversity of Animals. These photos give just an inkling of the diversity of organisms that belong to the animal kingdom. (A) Sponge, (B) Flatworm, (C) Flying Insect, (D) Frog, (E) Tiger, (F) Gorilla. 
 Question: if you find a single-celled organism living in a geyser, it probably belongs to which domain?

A: archaea
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Q: Context: The muscular system consists of all the muscles in the body. This is the body system that allows us to move. You also depend on many muscles to keep you alive. Your heart, which is mostly muscle, pumps blood around your body. Each muscle in the body is made up of cells called muscle fibers. Muscle fibers are long, thin cells that can do something that other cells cannot dothey are able to get shorter. Shortening of muscle fibers is called contraction. Muscle fibers can contract because they are made of proteins, called actin and myosin, that form long filaments (or fibers). When muscles contract, these protein filaments slide or glide past one another, shortening the length of the cell. When your muscles relax, the length extends back to the previous position. Nearly all movement in the body is the result of muscle contraction. You can control some muscle movements. However, certain muscle movements happen without you thinking about them. Muscles that are under your conscious control are called voluntary muscles. Muscles that are not under your conscious control are called involuntary muscles. Muscle tissue is one of the four types of tissue found in animals. There are three different types of muscle in the body ( Figure 1.1): 1. Skeletal muscle is made up of voluntary muscles, usually attached to the skeleton. Skeletal muscles move the body. They can also contract involuntarily by reflexes. For example, you can choose to move your arm, but your arm would move automatically if you were to burn your finger on a stove top. This voluntary contraction begins with a thought process. A signal from your brain tells your muscles to contract or relax. Quickly contract and relax the muscles in your fingers a few times. Think about how quickly these signals must travel throughout your body to make this happen. 2. Smooth muscle is composed of involuntary muscles found within the walls of organs and structures such as the esophagus, stomach, intestines, and blood vessels. These muscles push materials like food or blood through organs. Unlike skeletal muscle, smooth muscle can never be under your control. 3. Cardiac muscle is also an involuntary muscle, found only in the heart. The cardiac muscle fibers all contract together, generating enough force to push blood throughout the body. What would happen if this muscle was under conscious or voluntary control? There are three types of muscles in the body: cardiac, skeletal, and smooth. 
 Question: what muscle pushes food through your intestines?

A:
smooth muscle
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