In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

[Q]: Question: Urine is hypoosmolar with respect to plasma in: 
 Options:  <1> Bowman's capsule. <2> Proximal tubule <3> Medulla area of ​​the loop of Henle. <4> Initial zone of the distal tubule. <5> Collecting tubule in the presence of ADH.
[A]: 4


[Q]: Question: With regard to pyrogens and biotechnological medicines, it is possible to say: 
 Options:  <1> They have no tendency to aggregate or form large units with high molecular weight. <2> Ion exchange chromatography procedures (using their positive charge) can reduce endotoxin levels. <3> Ion exchange chromatography procedures (using their negative charge) can reduce endotoxin levels. <4> Ion exchange chromatography procedures (regardless of their charge) can reduce endotoxin levels. <5> They are unstable under standard autoclaving conditions.
[A]: 3


[Q]: Question: Within the main phases of extrusion and spheronization we have: 
 Options:  <1> Dry mix, wet kneading and compaction. <2> Wet kneading, compaction and drying. <3> Wet mixing, compaction, and drying. <4> Wet kneading, drying and sieving. <5> Kneading dry, drying and sieving.
[A]:
4