Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Jan Muhlstein (born 3 July 1949 in Most, Czechoslovakia) is a journalist, German Jewish activist and the former chair of the Union of Progressive Jews in Germany.
Which language or languages is Jan Mühlstein fluent in?

Spleen tyrosine kinase (Syk) is a cytoplasmic tyrosine kinase involved in signalling in many of the cells that drive immune inflammation. The development of small molecules that inhibit Syk kinase may change the way we treat disorders such as rheumatoid arthritis (RA), as well as a range of other inflammatory diseases. Fostamatinib (R-788) is an orally bioavailable small molecule. It is the prodrug of R406, which is a potent Syk inhibitor. Fostamatinib was developed because it has more favourable physiochemical properties. It is rapidly converted to R406 by intestinal enterocytes. It has been evaluated in experimental models of RA, such as collagen-induced arthritis. In these models, fostamatinib suppressed clinical arthritis, bone erosions, pannus formation and synovitis. A phase II programme with fostamatinib has largely been completed. Three key trials have been published, lasting 12-26 weeks and each enrolling 189-457 patients (875 in total). All these trials involved placebo therapy and patients continued to receive methotrexate in addition to active treatment with fostamatinib. The first dose-ranging trial evaluated three treatment doses in RA patients who had not fully responded to methotrexate therapy. The second trial compared two treatment doses in patients who had not responded to methotrexate therapy. The third trial compared a single treatment dose with placebo in patients who had not responded to biological therapy. The primary outcome measure was the number of patients achieving American College of Rheumatology (ACR) 20% (ACR20) responses. Placebo ACR20 response rates in all three trials were similar (35-38%). All three trials involved one treatment arm receiving fostamatinib 100 mg twice daily; ACR20 responses with this active treatment ranged from 38% to 67%. A meta-analysis of ACR responses in these trials, using responses to the highest dose in each trial for comparisons with placebo therapy in a random effects model, showed a borderline benefit with ACR20 responses. There were more significant differences with ACR50 and ACR70 responses. The reason that this meta-analysis was not more strongly positive is that the third trial, which evaluated patients who had failed to respond to biological treatments, gave negative results. Individual ACR response components, such as changes in swollen joint counts, showed significant differences in the first two trials, but there were no definite treatment benefits in the third trial. Overall, the differences were significant in a meta-analysis of all three trials. The most important adverse reactions were diarrhoea, neutropenia and raised ALT levels, which all showed significant excesses with active treatment compared with placebo. Too few patients have been studied for a definitive safety profile to be known. Overall, the results of the phase II trials were sufficiently encouraging for a phase III programme to be initiated. It will be some years before their definitive results are available.
Which enzyme is inhibited by a drug fostamatinib?

On an October morning in 1951, Norman Dale (Gene Hackman) drives through the Indiana countryside. In the afternoon he arrives in the small rural town of Hickory and enters the high school. He notices, on a shelf in the hall, basketball trophies won in previous years. As the bell rings to end the school day, he encounters teacher Myra Fleener (Barbara Hershey). She realizes that Norman must be the new basketball coach and teacher of history and civics. She directs him to the office of principal Cletus Summers (Sheb Wooley), where the two men recall how they met many years ago at Buffalo State Teachers College. They had lost touch until recently, when Cletus tracked down Norman and asked him to come coach at Hickory. When Norman thanks Cletus for the opportunity, Cletus interrupts and says, "Your slate's clean here." They proceed to the gym, where student Jimmy Chitwood (Maris Valainis) is shooting baskets. Cletus introduces Norman, but Jimmy ignores the new coach and keeps shooting.That evening on his farm, Cletus explains to Norman that Jimmy has been strongly affected by the recent death of the previous coach, who was like a father to Jimmy. Now the young man has withdrawn from almost everything and everyone and has decided not to play basketball this season. Cletus adds that Jimmy is the best player he has ever seen. As they finish talking, Norman cryptically mentions that he hopes things will work out for him this time.That night, Norman meets some of the townsmen in the barbershop, who bombard him with questions. He tells them he last coached 12 years ago, in Ithaca, New York, and that he has been in the Navy for the past 10 years. The men voice their opinions on what Norman should do with the team. They all agree that Jimmy must rejoin the Huskers for them to have a winning season. Losing patience with all the questions and unwelcome advice, Norman cuts short the meet-and-greet and leaves.The next morning, before school begins, Myra tells Norman that Jimmy is her neighbor, and she has been looking out for him ever since his father died. She thinks it best that he stay off the team. After school, the Huskers are already practicing in the gym when Norman walks in. George Walker (Chelcie Ross), one of the townspeople Norman met in the barbershop, is leading the practice and assumes that Norman will continue allowing him to assist. When Norman brusquely makes it clear that he doesn't need any help, George storms off. As Norman gathers the seven Huskers and begins to introduce himself, Buddy (Brad Long) rudely whispers to his teammate Whit (Brad Boyle), who is standing next to him. Norman orders Buddy to leave, and Buddy convinces Whit to go with him. Jimmy is watching, unseen, at one of the far exits. Norman begins the practice and puts the Huskers through drills of passing, running in place, and dribbling while weaving between chairs; they never scrimmage. Norman explains, "There's more to the game than shooting. There's fundamentals and defense." He also wants them to be in top physical condition because, if they continue to have only five players, substitutions and rest during games will be impossible. On the second day of practice, several townspeople walk in to observe; they've heard about Norman's unusual drills. Rollin Butcher (Robert Swan), Whit's father, brings in his son and has him apologize for walking out the day before. Rollin then tells the other men to leave, because the coach doesn't want them there.One day, as Cletus and Norman eat pie at the diner downtown, in comes Wilbur "Shooter" Flatch (Dennis Hopper), stumbling a bit and wearing a worn-out coat. Shooter, a former basketball player, describes for Norman how he almost led his team to victory in the 1933 sectional game of the tournament on a last-second shot. When Shooter asks Cletus in a low voice if he can borrow some spare change, Shooter's son, Everett (David Neidorf), who

Who is to join him on the bench as a new assistant?