In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Q: Coronavirus-like particles were identified by electronmicroscopy in the feces of homosexual men. The particles banded at a density of 1.21 g/ml after cesium chloride density gradient centrifugation. To determine whether the presence of this virus might be related to clinical symptoms, several patient groups were studied prospectively. In 8 of 16 (50%) homosexual males with acquired immunodeficiency syndrome (AIDS) or unexplained lymphadenopathy syndrome (LAS), coronavirus particles were found. In contrast, such particles were found in none of 18 heterosexual controls and in only 3 of 20 homosexual males without AIDS or LAS. Thus, coronavirus excretion correlated significantly (2c~<0.01) with the clinical diagnosis of AIDS or with syndromes belonging to the AIDS-related complex. In addition, such particles identified in the serum of one patient with LAS and diarrhea suggest invasion and systemic spread of the agent and underline that this virus behaves differently from" common cold" human coronaviruses.

A: Kiinische Wochen- schrift Detection of Coronavirus-Like Particles in Homosexual Men with Acquired Immunodeficiency and Related Lymphadenopathy Syndrome
****
Q: Toxoplasma gondii is a worldwide spread protozoan and is able to infect almost all warm-blood animals. No effective drugs are available clinically on toxoplasmosis. Chinese traditional herbal medicines have provided remedies for many health problems. There exists a possibility that Chinese herbs may provide protection against T. gondii. This work aims to assess the protective efficacy of combined Chinese herbs against T. gondii. We screened five herbal medicines that have different pharmacological effects and combined them into a prescription according to the traditional Chinese medicine compatibility principle. The drug potential and protective efficacy were evaluated through a mouse model by determining the survival time, the parasite load in blood and tissues, the change of cell proportions in blood and histological detection. The results showed that the survival time of mice in the 500 mg Chinese herbs group and sulfadiazine group was significantly longer than that of the PBS control group. Also the parasite load in blood and tissues of 500 mg Chinese herbs and sulfadiazine groups was significantly lower than that of PBS group at 7 days post infection (dpi), which was in accordance with the result of histological detection. Monocyte and neutrophil of infected mice were remarkably increased while lymphocyte was dramatically decreased compared to that of blank group at 7 dpi. The results demonstrated that the 500 mg dosage of our Chinese herbs could slow down the replication of T. gondii and prolong the survival time of mice and could be considered as possible candidate drug against toxoplasmosis.

A: Evaluation of potential anti-toxoplasmosis efficiency of combined traditional herbs in a mouse model *
****
Q: Since the 1980s the epidemiology of Clostridium difficile infection (CDI) has been investigated by the application of many different typing or fingerprinting methods. To study the epidemiology of CDI, a typing method with a high discriminatory power, typeability, stability, power, reproducibility and epidemiological concordance is required. It should also have technical advantages, such as ease of performance, relative low cost, and high throughput. A growing number of molecular methods have been applied to C. difficile. For the early and rapid detection of outbreak situations, methods such as restriction enzyme analysis, arbitrary primed polymerase chain reaction (PCR), pulsed-field gel electrophoresis, and PCR ribotyping are commonly used. For long-term epidemiology, multilocus sequence typing, multilocus variable number of tandem repeats analysis (MLVA), and amplified fragment length polymorphism are of interest. Currently, the PCR-ribotyping method and the library of PCR ribotypes in Cardiff are the benchmarks to which most typing studies around the world are compared. Conventional agarose gel-based PCR ribotyping is easy to use and relatively cheap, but analysis of fragment lengths is hampered by poor resolution. Recently, a capillary gel electrophoresisbased PCR ribotyping assay has been developed that significantly reduces the hands-on time required for C. difficile PCR ribotyping. The results were highly reproducible, independent of reagent batches or brands used and allows inter-laboratory comparisons of typing results. The analysis of the sequenced C. difficile genome revealed a high percentage of DNA that consisted of a variable number of tandem repeats (VNTR). Recently, a new MLVA method was developed using smal short tandem repeats (2−9 bp) to facilitate automated fragment analysis with multicoloured capillary electrophoresis instead of sequencing. In a study using isolates from laboratories in Canada, the Netherlands, the United Kingdom, and the United States, seven C. difficile typing techniques were compared, but only REA and MLVA showed sufficient discrimination to distinguish strains from different outbreaks. MLVA has also been applied to study local outbreaks of C. difficile PCR ribotype 027 strains. MLVA is currently the most discriminative typing method and will contribute significantly to our understanding of the epidemiology of C. difficile. S3 New treatment aspects of CDI The need for new therapeutic alternatives in CDI is clear. Current recurrence rates are unacceptably high. The optimal treatment of severe CDI, infection caused by strains associated with poor outcome (e.g. C. difficile ribotype 027), and multiple recurrences is unclear. There are several potentially promising new CDI treatment approaches under investigation, including antibiotic, anti-toxin and bacterial interference options. Probiotic therapy remains of unproven benefit. As new options become available, prognostic data will be needed to guide on the most approriate therapeutic choices.

A:
Oral presentations New aspects of emerging Clostridium difficile infections (CDI) S2 Pros and cons of molecular fingerprinting for Clostridium difficile infections
****