Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Heavily in debt, Clinton lobbied the Duke of Newcastle for profitable employment as an American governor: he was appointed Governor of the Province of New York in July 1741 and arrived in New York in September 1743 to take up his position. Promoted to rear-admiral on 10 December 1743 and vice-admiral on 23 June 1744, he sought to protect New York's Northern border from attack by the French: however liberal members of the New York assembly resisted his proposals as they wanted to maintain trade links with the French and with the Native Americans who were under French influence. James De Lancey, who had initially been his main adviser, turned against him and sought to block the governor's salary. Clinton therefore invited Sir William Johnson to take over responsibility for Native American affairs in 1746 and appointed Cadwallader Colden to be his advisor. Clinton was promoted to full admiral on 15 July 1747. Working with the Mohawk chief Hendrick Theyanoguin, Johnson was able to recruit Mohawk warriors to fight on the side of the British in 1747 during King George's War. After continuing disputes with the assembly over military expenditure and payment of the governor's salary, Clinton resigned as governor in October 1753.

Answer: What happened second: Clinton was appointed Governor or promoted to rear-admiral?


Question: Tumors of the nervous system most often occur in both children and adults as sporadic events with no family history of the disease, but they are also among the clinical manifestations of a significant number of familial cancer syndromes, including familial retinoblastoma, neurofibromatosis 1 and 2, tuberous sclerosis, and Cowden, Turcot, Li-Fraumeni and nevoid basal cell carcinoma (Gorlin) syndromes. All of these syndromes involve transmissible genetic risk resulting from loss of a functional allele, or inheritance of a structurally defective allele, of a specific gene. These genes include RB1, NF1, NF2, TSC1, TSC2, TP53, PTEN, APC, hMLH1, hPSM2, and PTCH, most of which function as tumor suppressor genes. The same genes are also observed in mutated and inactive forms, or are deleted, in tumor cells in sporadic cases of the same tumors. The nature of the mutational events that give rise to these inactivated alleles suggests a possible role of environmental mutagens in their causation. However, only external ionizing radiation at high doses is clearly established as an environmental cause of brain, nerve and meningeal tumors in humans. Transplacental carcinogenesis studies in rodents and other species emphasize the extraordinary susceptibility of the developing mammalian nervous system to carcinogenesis, but the inverse relationship of latency to dose suggests that low transplacental exposures to genotoxicants are more likely to result in brain tumors late in life, rather than in childhood. While not all neurogenic tumor-related genes in humans have similar effects in experimental rodents, genetically engineered mice (GEM) increasingly provide useful insights into the combined effects of multiple tumor suppressor genes and of gene-environment interactions in the genesis of brain tumors, especially pediatric brain tumors such as medulloblastoma.

Answer: Which is the gene mutated in type 1 neurofibromatosis?


Question: Athole Shearer (November 20, 1900 -- March 17, 1985) was an actress most noted as the sister of motion picture star Norma Shearer and film sound engineer Douglas Shearer.

Answer:
Who is Athole Shearer's sister?