TASK DEFINITION: Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
PROBLEM: Context: Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, demonstrated efficacy and safety in moderate-to-severe plaque psoriasis when administered via subcutaneous injection. Self-administration by pre-filled syringe (PFS) can offer patients clinical benefits of a drug, with increased convenience. To assess efficacy, safety and usability of secukinumab administration via PFS in subjects with moderate-to-severe plaque psoriasis. Subjects in this phase 3 trial were randomized 1:1:1 to secukinumab 300 or 150mg or matching placebo. Results to week 12 are presented here. Each treatment was delivered using a PFS once weekly to week 4, and again at week 8. Co-primary endpoints were secukinumab superiority over placebo for week 12 PASI 75 (75% reduction in Psoriasis Area and Severity Index) and IGA mod 2011 (2011 modified Investigator's Global Assessment) 0/1 response rates. Secondary endpoints included PFS usability, determined by observer rating of successful, hazard-free self-injection and subject rating of acceptability by the Self-Injection Assessment Questionnaire (SIAQ). Co-primary endpoints were met, with demonstration of superiority for each secukinumab dose vs. placebo at week 12 (PASI 75: 759%, 695% and 0% for secukinumab 300mg, 150mg and placebo; IGA mod 2011 0/1: 690%, 525% and 0%, respectively; P<00001 for all comparisons vs. placebo). PFS usability was high: 100% of subjects successfully self-administered treatment at week 1, and subjects reported high SIAQ-assessed acceptability of the PFS throughout the trial. No new/unexpected safety signals were observed. Secukinumab administration by PFS was effective, with an acceptable safety profile and high usability. The PFS provides a reliable, convenient form of secukinumab administration in subjects with moderate-to-severe plaque psoriasis. 
 Question: Which molecule is targeted by a monoclonal antibody Secukinumab?

SOLUTION: interleukin-17a

PROBLEM: Context: New Orleans narcotics detective Anthony Stowe (Jean-Claude Van Damme) is a heroin addict who is teetering on the edge of oblivion, and he couldn't care less.At the moment, Stowe is trying to bring down his former partner Gabriel Callahan (Stephen Rea), who has become a drug kingpin. Callahan is trying to, and slowly succeeding at, taking over the New Orleans underworld.Stowe botches a sting operation against Callahan, resulting in the death of fellow cop Maria Ronson (Rachel Grant), whose fiancee, fellow cop Van Huffel (Adam Leese), is furious at Stowe. Chief Mac Baylor (Gary Beadle) has a very blunt chat with Stowe about it. Stowe is approached by fellow cop Walter Curry (Trevor Cooper) to help his nephew beat a drug-dealing charge. Stowe instead turns him over to Baylor, who fires him. After barricading himself in the station bathroom, Walter confronts an unrepentant Stowe and condemns him for betraying his fellow officers.Later, Van Huffel berates Stowe for getting Maria killed. Stowe responds by attacking Van Huffel in front of several officers. Later, Stowe meets with his estranged wife Valerie (Selina Giles), who tells him that she's pregnant, but that he's not the father. Valerie, whose marriage with Stowe is on the rocks, has been seeing a man named Mark Rossini (Mark Dymond), the gym teacher at the school she is principle of. But he may not be the father either. Stowe brashly accuses Valerie of being impregnated by Callahan, and Valerie tells him she never wants to see him again.The only thing keeping Stowe from total collapse is his dogged pursuit of Callahan. But he drunkenly stumbles into an ambush masterminded by Callahan, and is shot in the head by Callahan's right-hand man Jimmy (Stephen Lord).Stowe undergoes emergency surgery, and ends up in a coma. Months later, he recovers to the point that he opens his eyes, and is transported to his and Valerie's house to recover properly.Seven months after getting shot, Stowe has recovered a lot, although he must learn to walk and speak again. He manages to survive an attempt on his life, by someone who appears to be a cop. He's recovered enough to try to get his job back, but that's the one thing that Chief Baylor doesn't want to give him. The coma has led to his decision to become a better man, and to right some wrongs. He reconciles with his wife, although awkwardly, and gives Walter a check for $40,000, part of his insurance money that compensated his time in a coma. Finally, he visits the grave of fellow police officer Serge (William Ash), who once saved Stowe's life but has been killed by an unknown attacker following another failed sting operation.Valerie packs up to move out of the house so she can live with Mark, but after realizing the change that Stowe has undergone, she later decides to leave Mark and come back home. Stowe is convinced by his friend Chad Mansen (Wes Robinson) not to let his wife go, and Stowe goes after her. They miss each other by a few minutes.Just after Valerie returns and meets Chad, some of Callahan's men show up. Jimmy kills Chad, and kidnaps Valerie. Stowe returns to the house, and finds Chad's body, along with Jimmy waiting for him.Van Damme promoting the film in 2007Jimmy takes Stowe to a warehouse where Callahan is waiting. Along the way, Stowe manages to overpower Jimmy and take his gun, but he finds that the odds against him are impossible- and Callahan has Valerie hostage. Van Huffel is revealed to be Callahan's mole on the police force, and the sting operation at the beginning of the film was a set-up. Walter suddenly arrives and saves Stowe. Together they kill all of Callahan's men, including Jimmy and Van Huffel, as Callahan tries to escape with Valerie to his helicopter. Just as Callahan is about to reach it, Stowe appears.In the European DVD ending, each fire a shot that kills the other. Valerie cries out 
 Question: Who does Valerie want to live with when she leaves the house?

SOLUTION: mark

PROBLEM: Context: England, 1694. Mrs Herbert (Janet Suzman) and her daughter Mrs Talmann (Anne-Louise Lambert) try to persuade Mr Neville (Anthony Higgins), an artist, to make a series of drawings of Mr and Mrs Herbert's house and estate. Mr Neville finally agrees when Mrs Herbert offers, in addition to paying for each drawing and giving him room and board while he draws, to sleep with him. (Oddly, she makes this offer in the presence of her husband's agent, Mr Noyes (Neil Cunningham), who is drawing up the contract.) Mrs Herbert intends the drawings to be a gift to her obnoxious and estranged husband, who dotes on his property and who is conveniently planning to be away from home while the drawings are created.Mr Neville inconveniences the entire household with detailed and stringent requirements for his 12 drawings. For specified periods every day, the views he has chosen must be kept clear of carriages, animals, smoking chimneys, and people -- except for the one that requires Mr Talmann (Hugh Fraser) to stand still and wear the same clothes for several days running.The atmosphere of the film is chilly; there's little indication that any of the characters like one another, and many of them are fairly hostile. Starting over the issue of Mr Talmann's wardrobe, Mr Talmann and Mr Neville snipe at one another continuously. Mr and Mrs Talmann have a bitter confrontation. It's hard to tell what the exaggerated costumes are meant to contribute: comically tall headpieces for the women, and for the men, very long, curly wigs -- waist-length, in some cases -- which, along with full-skirted coats, make them look like Edwardian schoolgirls.Mrs Herbert is distressed by the sexual part of her agreement and tries to break the contract; Mr Neville refuses. Mrs Talmann makes her own bargain for sexual favors with Mr Neville (which doesn't affect her mother's). Later, we learn that Mr Talmann is impotent -- and also that Mr Herbert doesn't believe that women should own property, so the inheritance of the estate depends on Mrs Talmann producing a son.Mr Herbert's injured horse turns up, and shortly thereafter his body is found in the moat. Mr Noyes, the agent, who as a young man wanted to marry Mrs Herbert, comes to her demanding assistance because he believes he will be suspected of murdering Mr Herbert. Mrs Herbert shows no interest in helping him, so Mr Noyes blackmails her: if she doesn't give him the drawings (why does he want the drawings?), he'll make the draughtsman's contract public, exposing her as an adulteress.Mrs Talmann observes that many of the drawings include objects that have no business being where they are: a ladder leading to Mrs Talmann's bedroom window; a pair of boots belonging to her husband; and several items of clothing belonging to Mr Herbert. Mrs Talmann implies that Mr Neville is planting clues related to the demise of Mr Herbert. But Mr Neville is clearly drawing what he sees, and we have no evidence that he's responsible for the presence of any of the misplaced objects.An odd feature of the landscape is a moving statue (Michael Feast), which turns up twined with vines against a wall, on the roof while Mrs Herbert and her guests are eating an outdoor meal in the foreground, and on a pedestal from which it first removes an obelisk.Having completed his contract and gone away, Mr Neville comes back for a visit. Mrs Herbert offers him one more tryst in exchange for one more drawing, and he agrees. He completes a view of an equestrian statue in the garden, though he draws the horse without its rider. It's not apparent whether this is because he can't see the rider -- the moving statue may not be visible to everyone -- or because Mr Neville is alluding to the death of Mr Herbert.Although his drawing is done, Mr Neville continues to sit by the statue. As it grows dark, he's surrounded by a group of masked gentlemen, most of whom are recognizable as members of the Herbert household or their 
 Question: Who's body is discovered in the moat of the house?

SOLUTION:
mr. herbert's