Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Example Input: The anti-epileptic agent trimethadione was given orally to 30 outpatients at a dose of 0.9-1.5 g daily.
Example Output: non-adverse drug event

Example Input: A 54-year-old man, treated with amiodarone, developed thyrotoxicosis.
Example Output: adverse drug event

Example Input: Rapid identification of speech loss linked to FK506 may be important because reduction or cessation of the drug may be associated with reverse of speech loss.
Example Output:
adverse drug event