Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
Chronic myeloid leukemia (CML) is arguably the best understood of all human malignancies. Its origins in the hematopoietic stem cell can be traced to a reciprocal translocation involving chromosomes 9 and 22, dubbed the Philadelphia chromosome, which is observed in essentially all patients. The resulting fusion gene, BCR/ABL, encodes an activated tyrosine kinase that can act alone to induce a CML-like syndrome in mouse models. These animal models have validated BCR/ABL as a target for the development of specific pharmaceutical inhibitors. The kinase inhibitor imatinib mesylate (Gleevec) is highly specific, effective, and minimally toxic, but may not effect cures as a single agent, particularly in patients with accelerated and blast-phase disease. Resistance to imatinib can confound therapy. Surprisingly, a high percentage of resistant cases manifest intact or augmented BCR/ABL signaling, suggesting that this oncoprotein, or signaling pathways emanating from it, remain viable targets. Combination chemotherapy is under active investigation, and among the most compelling strategies is dual treatment with agents that both target BCR/ABL signal transduction. BCR/ABL activates Ras, and compounds designed to antagonize Ras function called farnesyl transferase inhibitors (FTIs) have shown potent activity in vitro and in animal models of BCR/ABL-induced leukemia. Initial clinical trials in patients with refractory acute myeloid leukemia and CML in blast crisis have shown significant activity, suggesting that trials combining imatinib and FTIs are warranted.

Ex Output:
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Ex Input:
"When I grow up, I want to be..." Almost all of us have thought about, or been asked to think about, our future careers. Our answers may differ greatly. Even now your aspirations may have changed from when you were in primary school. However, it seems career options aren't only based on personal taste. In a survey carried out by Teens, doctors, lawyers, and bankers were some of most popular careers that people said they hoped to follow. This is in line with a similar survey carried out in the UK in May 2011 by job website monster. Co.uk, in which medicine was the top choice among UK teenagers aged between 13 and 17. Medicine and law are two of the oldest and best known professions. Their prestige may come from the fact that doctors and lawyers are some of the most esteemed members of society, and they make good money. Joining these high-profile professions is often seen as a sign of upward social mobility. It is equally unsurprising that banking is now one of the most common career choices. Youngsters worldwide think of banking and see the money rolling in. Wealth is increasingly becoming one of the most important indicators of a successful career. British young men list the UK tycoon Alan Sugar, Microsoft founder Bill Gates and Facebook chief Mark Zuckerberg as their top role models "for their wealth". Just as Chinese teenagers see being a banker as a good and fun pathway to "wealth". However, not every child has the makings of doctor, lawyer, or banker. They are those who see fulfillment and happiness in other areas, and many teenagers dare to ink more individuality into their career options. As the Teens' survey discovered, a variety of unconventional jobs---coffee shop owner, gourmet ,waiter at a fast food restaurant---are among teenagers' career choices. They can be equally interesting and rewarding jobs. With every choice comes responsibility and challenge, and all career paths require specific education and training, you have to learn to balance optimism and confidence with being realistic about your particular talents and skills.

Ex Output:
What is the top career choice among UK teenagers aged between 13 and 17 according to the article?


Ex Input:
The opening crawl reveals that Han Solo's friends are engaged in a mission to rescue the smuggler from Jabba the Hutt and that the Galactic Empire is building a new armored space station which is even larger and more powerful than the first Death Star.Near the forest moon of Endor the new Death Star is being constructed in orbit, and a command star destroyer arrives and launches a shuttle with a fighter escort -- a shuttle bearing the Dark Lord of the Sith. Fearing his arrival, the commander of the new Death Star informs Darth Vader (David Prowse, voice: James Earl Jones) that the station will be operational on schedule, but when Vader challenges this "optimistic" appraisal of the situation, the commander admits that he needs more men to accelerate construction. Darth Vader, however, informs the commander that the Emperor (Ian McDiarmid) will be arriving soon, and that he is most displeased with the commander's progress. Shaken, the commander commits to redoubling construction efforts. Vader, pleased, remarks, "the Emperor is not as forgiving as I am."Jedi Knight Luke Skywalker (Mark Hamill), Chewbacca (Peter Mayhew), Lando Calrissian (Billy Dee Williams), Princess Leia Organa (Carrie Fisher), C-3PO (Anthony Daniels), and R2-D2 (Kenny Baker) return to Tatooine to rescue Han Solo (who was encased in carbonite at the end of Star Wars: Episode V - The Empire Strikes Back) from the gangster Jabba the Hutt (voice: Larry Ward). Luke sends C-3PO and R2-D2 to Jabba's desert palace to deliver a message: In a hologram projected by R2, Luke offers to bargain with Jabba for Solo himself -- if Jabba does not, he will be destroyed. Jabba laughs at the message and refuses to give up his "favorite decoration:" Han, frozen in carbonite, hangs on a wall in Jabba's court. The two droids are sent to EV-9D9's workshop where C-3P0 is given the job of Jabba's translator and R2 will be a drink-server on Jabba's sail barge.Disguised as a bounty hunter named Boushh, Leia arrives in Jabba's court with Chewbacca in cuffs. She offers him to Jabba for a sizable bounty. After Leia dickers with Jabba over the amount and threatens him with a small thermal detonator, Jabba happily agrees to pay, impressed with the bounty hunter's nerve, and Chewbacca is imprisoned.That night, Leia sneaks into Jabba's court and frees Han from the carbonite. However, she and Solo are both captured by Jabba. Solo is imprisoned with Chewbacca and Jabba keeps Leia on display in a metal bikini and chains. Luke arrives with a final ultimatum to release Solo. Jabba again refuses and drops Luke through a trap door into a pit below his throne that houses the rancor, a fearsome beast that Jabba keeps for executions. As Leia watches in horror, she sees Lando Calrissian disguised as a palace guard. After a brief battle, Luke defeats the rancor, enraging Jabba, who declares that Luke, Solo and Chewbacca will be slowly consumed by the sarlacc -- a huge, shark-toothed, tentacled maw at the bottom of the Great Pit of Carkoon.The group is taken to the pit on Jabba's sail barge fleet and prepared for execution: Luke is the first, pushed out onto a thin plank over the pit. Luke gives R2 a short salute and a small object, Luke's new lightsaber, is launched into his hand. A battle erupts, with Luke steadily taking the fight to Jabba's men. During the battle, Leia strangles Jabba with the chain around her neck and with R2-D2's help escapes from her bonds. Solo accidentally knocks Boba Fett (Jeremy Bulloch) into the sarlacc pit. Lando is also thrown off one of the skiffs, hanging by a few cables until he's rescued from the sarlacc itself by Han and Chewbacca. Luke, having fought his way onto Jabba's sail barge, has the escaping Leia aim the deck cannon at the vehicle and sets it on automatic fire; the sail barge soon blows apart. Our heroes manage to escape before it explodes, retrieve R2 and C-3PO and zip off into the desert.

Ex Output:

Who kills the Emperor?