Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Example Input: CONCLUSIONS: We report this case of the concomitant appearance of multiple skin cancers and nail changes associated with hydroxyurea use.
Example Output: adverse drug event

Example Input: Clinical and electrodiagnostic findings are discussed in detail and a brief review of the literature is presented.
Example Output: non-adverse drug event

Example Input: Methadone-induced myoclonus in advanced cancer.
Example Output:
adverse drug event