TASK DEFINITION: Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
PROBLEM: Context: DNA must replicate (copy) itself so that each resulting cell after mitosis and cell division has the same DNA as the parent cell. All these cells, the parent cell and the two new daughter cells, are genetically identical. DNA replication occurs during the S phase (the Synthesis phase) of the cell cycle, before mitosis and cell division. The base pairing rules are crucial for the process of replication. DNA replication occurs when DNA is copied to form an identical molecule of DNA. The general steps involved in DNA replication are as follows: 1. The DNA helix unwinds like a zipper as the bonds between the base pairs are broken. The enzyme DNA Helicase is involved in breaking these bonds. 2. The two single strands of DNA then each serve as a template for a new stand to be created. Using DNA as a template means that on the new strand, the bases are placed in the correct order because of the base pairing rules. Recall that A and T are complementary bases, as are G and C. As a template strand is read, the new strand is created. If ATGCCA is on the "template strand," then TACGGT will be on the new DNA strand. The enzyme DNA Polymerase reads the template and builds the new strand of DNA. 3. The new set of nucleotides then join together to form a new strand of DNA. The process results in two DNA molecules, each with one old strand and one new strand of DNA. This process is known as semiconservative replication because one strand is conserved (kept the same) in each new DNA molecule ( Figure 1.1). DNA replication occurs when the DNA strands unzip, and the original strands of DNA serve as a template for new nucleotides to join and form a new strand. 
 Question: what is the first step in dna replication?

SOLUTION: the dna helix unwinds like a zipper.

PROBLEM: Context: September 1939. Mrs. Kay Miniver (Greer Garson) and her family live a comfortable life at a house called 'Starlings' in Belham, a fictional village outside London, England. The house has a large garden, with a private landing stage on the River Thames at which is moored a motorboat belonging to her devoted husband Clem (Walter Pidgeon), a successful architect. They have three children: the youngsters Toby and Judy (Christopher Severn and Clare Sandars) and an older son Vin (Richard Ney) at university. They have live-in staff: Gladys the housemaid (Brenda Forbes) and Ada the cook (Marie De Becker).As World War II looms, Vin comes down from university and meets Carol Beldon (Teresa Wright), granddaughter of Lady Beldon (Dame May Whitty) from nearby Beldon Hall. Despite initial disagreements (mainly contrasting Vin's idealistic attitude to class differences with Carol's practical altruism) they fall in love. Vin proposes to Carol in front of his family at home after his younger brother prods him to give a less romantic but more honest proposal.Several months later, as the war comes closer to home with the bombing of Great Brittan, Vin feels he must "do his bit" and enlists in the Royal Air Force, qualifying as a fighter pilot. He is posted to a base near to his parents' home and is able to signal his safe return from operations to his parents by cutting his engines briefly as he flies over the house. Together with other boat owners, Clem volunteers to take his motorboat to assist in the May-June 1940 Dunkirk evacuation.Early one morning, Kay unable to sleep as Clem is still away, wanders down to the landing stage. She is startled to discover a wounded German pilot (Helmut Dantine) hiding in her garden and he holds her at gunpoint. Demanding food and a coat, the pilot maniacally asserts that the Third Reich will mercilessly overcome its enemies. She feeds him, calmly disarms him and then calls the police. Soon after, Clem returns home, exhausted, from Dunkirk.Lady Beldon visits Kay to try and convince her to talk Vin out of marrying Carol on account of her granddaughter's comparative youth. Lady Beldon is unsuccessful and admits defeat when Kay reminds her that she, too, was young when she married her late husband. Lady Beldon concedes defeat and realises that she would be foolish to try and stop the marriage. Vin and Carol are married; Carol has now also become Mrs Miniver, and they return from their honeymoon in Scotland. A key theme is that she knows he is likely to be killed in action, but the short love will fill her life. Later, Kay and her family take refuge in their Anderson shelter in the garden during an air raid, and attempt to keep their minds off the frightening bombing by reading Alice's Adventures in Wonderland, which Clem refers to as a "lovely story" as they barely survive a bomb destroys parts of the house. They take the damage with nonchalance.At the annual village flower show, Lady Beldon silently disregards the judges' decision that her rose is the winner, instead announcing the entry of the local stationmaster, Mr. Ballard (Henry Travers), named the "Mrs. Miniver" rose, as the winner, with her own rose taking second prize. As air raid sirens sound and the villagers take refuge in the cellars of Beldon Hall, Kay and Carol drive Vin to join his squadron. On their journey home they witness fighter planes in a 'dogfight'. For safety, Kay stops the car and they see the German plane crash. Kay realises Carol has been wounded by shots from the plane and takes her back to 'Starlings'. She dies a few minutes after they reach home. Kay is devastated. When Vin returns from battle, he already knows the terrible news. Unexpectedly he is the survivor, and she the one who gives her life for England.The villagers assemble at the badly damaged church where their vicar (Henry Wilcoxon) affirms their determination in a powerful sermon:"We in this quiet corner of England have suffered the loss of friends very dear to us, some 
 Question: Where did the villagers take refuge from air sirens?

SOLUTION: anderson shelter in the garden

PROBLEM: Context: Facioscapulohumeral muscular dystrophy (FSHD) is a dominant disease linked to contraction of an array of tandem 3.3-kb repeats (D4Z4) at 4q35. Within each repeat unit is a gene, DUX4, that can encode a protein containing two homeodomains. A DUX4 transcript derived from the last repeat unit in a contracted array is associated with pathogenesis but it is unclear how. Using exon-based microarrays, the expression profiles of myogenic precursor cells were determined. Both undifferentiated myoblasts and myoblasts differentiated to myotubes derived from FSHD patients and controls were studied after immunocytochemical verification of the quality of the cultures. To further our understanding of FSHD and normal myogenesis, the expression profiles obtained were compared to those of 19 non-muscle cell types analyzed by identical methods. Many of the ~17,000 examined genes were differentially expressed (>2-fold, p<0.01) in control myoblasts or myotubes vs. non-muscle cells (2185 and 3006, respectively) or in FSHD vs. control myoblasts or myotubes (295 and 797, respectively). Surprisingly, despite the morphologically normal differentiation of FSHD myoblasts to myotubes, most of the disease-related dysregulation was seen as dampening of normal myogenesis-specific expression changes, including in genes for muscle structure, mitochondrial function, stress responses, and signal transduction. Other classes of genes, including those encoding extracellular matrix or pro-inflammatory proteins, were upregulated in FSHD myogenic cells independent of an inverse myogenesis association. Importantly, the disease-linked DUX4 RNA isoform was detected by RT-PCR in FSHD myoblast and myotube preparations only at extremely low levels. Unique insights into myogenesis-specific gene expression were also obtained. For example, all four Argonaute genes involved in RNA-silencing were significantly upregulated during normal (but not FSHD) myogenesis relative to non-muscle cell types. DUX4's pathogenic effect in FSHD may occur transiently at or before the stage of myoblast formation to establish a cascade of gene dysregulation. This contrasts with the current emphasis on toxic effects of experimentally upregulated DUX4 expression at the myoblast or myotube stages. Our model could explain why DUX4's inappropriate expression was barely detectable in myoblasts and myotubes but nonetheless linked to FSHD. 
 Question: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?

SOLUTION:
fshd