Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Q: Context: Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy. We enrolled 457 patients who had active rheumatoid arthritis despite long-term methotrexate therapy in a 6-month, double-blind, placebo-controlled trial. The primary outcome was the American College of Rheumatology (ACR) 20 response (which indicates at least a 20% reduction in the number of both tender and swollen joints and improvement in at least three of five other criteria) at month 6. R788, at a dose of 100 mg twice daily and at a dose of 150 mg once daily, was significantly superior to placebo at month 6 (ACR 20 response rates of 67% and 57%, respectively, vs. 35%; P<0.001 for the comparison of both doses with placebo). It was also significantly superior with respect to ACR 50, which indicates at least a 50% improvement (43% and 32% vs. 19%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.007 for the comparison of the 150-mg dose with placebo) and ACR 70 (28% and 14% vs. 10%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.34 for the comparison of the 150-mg dose with placebo). A clinically significant effect was noted by the end of the first week of treatment. Adverse effects included diarrhea (in 19% of subjects taking the 100-mg dose of R788 vs. 3% of those taking placebo), upper respiratory infections (14% vs. 7%), and neutropenia (6% vs. 1%). R788 was associated with an increase in systolic blood pressure of approximately 3 mm Hg between baseline and month 1, as compared with a decrease of 2 mm Hg with placebo; 23% of the patients taking R788 vs. 7% of the patients receiving placebo required the initiation of or a change in antihypertensive therapy. In this phase 2 study, a Syk inhibitor reduced disease activity in patients with rheumatoid arthritis; adverse events included diarrhea, hypertension, and neutropenia. Additional studies will be needed to further assess the safety and efficacy of Syk-inhibition therapy in patients with rheumatoid arthritis. (Funded by Rigel; ClinicalTrials.gov number, NCT00665925.) 
 Question: Which enzyme is inhibited by a drug fostamatinib?

A: spleen tyrosine kinase
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Q: Context: For travellers who want to experience some of the history and mystery of the ancient world, here is a list of cool destinations for your next holiday. Angkor Wat, Cambodia Built in the 12th century, Angkor Wat (meaning "capital monastery") was a temple in the ancient Khmer capital city of Angkor. It is Cambodia's best-known tourist attraction and is famed for its beautiful architecture and reliefs. You'll need at least three days to fully discover the delights of this magnificent site. Machu Picchu, Peru Machu Picchu was built high in the Andes Mountains of South America by the Inca in the 15th century. Although well preserved its exact purpose is unknown. It is famous throughout the world not only for its incredible design but also for the natural beauty that surrounds it. Give yourself a week to explore this magnificent site. Stonehenge, England The entire Stonehenge site was constructed over thousands of years. But why and how it was built remains a mystery. As the weather can be pretty bleak in winter and the crowds huge in summer, we suggest autumn should be the best time to visit these monster rocks. Pompeii, Italy When Mount Vesuvius erupted in 79 A.D., Pompeii was buried under many layers of ash, preserving the city exactly as it was when the volcano erupted. Because so many objects were preserved, scientists and visitors are able to better understand daily life in the ancient Roman Empire. 
 Question: Which location offers the most direct view into daily life in the ancient world?

A: pompeii.
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Q: Context: In the opening scene, private detective Sam Grunion (Groucho Marx) explains to the viewers that he has been searching for the extremely valuable Royal Romanoff diamonds for eleven years, and his investigation leads him to a troupe of struggling performers, led by Mike Johnson (Paul Valentine), who are trying to put on a musical revue called 'Love Happy'.Grunion notes that the impoverished young dancers would starve were it not for the sweet, silent Harpo (Harpo Marx), at Herbert & Herbert, a gourmet food shop that also trafficks in stolen diamonds. Harpo kindly helps ladies with their shopping bags, all the while pilfering their groceries and stuffing them in the pockets of his long trench coat. When the elegant Madame Egelichi (Ilona Massey) arrives, store manager Lefty Throckmorton (Melville Cooper) tells her that "the sardines" have come in. Harpo sneaks into the basement and watches as Lefty lovingly unpacks a sardine can marked with a Maltese cross, and swipes the can from Lefty's pocket, replacing it with an unmarked one. Madame Egelichi, who has gone through eight husbands in three months in her quest for the Romanoff diamonds, is furious when Lefty produces the wrong can. When Lefty remembers seeing Harpo in the basement, she orders him to call the police and offer a $1,000 reward for his capture.At the theater, meanwhile, unemployed entertainer Faustino the Great (Chico Marx) asks Mike for a job as a mind-reader, and when Faustino's clever improvisation stops the show's backer, Mr. Lyons (Leon Belasco), from repossessing the scenery, Mike gratefully hires him. Harpo, who is secretly in love with dancer Maggie Phillips (Vera-Ellen), Mike's girl friend, gives her the sardine can, and she says she will eat them tomorrow. A policeman sees Harpo inside the theater and brings him to Madame Egelichi, who turns Harpo over to her henchmen, Alphonse (Raymond Burr) and Hannibal (Bruce Gordon) Zoto. After three days of interrogation, Harpo still refuses to talk, and when he is left alone, he calls Faustino at the theater, using the bike horn he carries in his pocket to communicate. Madame Egelichi listens on the extension as Faustino declares that there are plenty of sardines at the theater, and she goes there at once.Meanwhile, Mike has just finished telling the troupe that they do not have enough money to open when Madame Egelichi arrives and offers to finance the show. Mike cancels his plans to take Maggie out for her birthday so that he and his new backer can discuss the arrangements. In the alley outside the theater, Harpo, having escaped from Madame Egelichi's suite, finds the diamonds in the sardine can which had been set out for a cat, and puts them in his pocket. When he finds Maggie crying in her dressing room, Harpo takes her to Central Park, where he plays the harp for her and gives her the diamonds as a birthday gift.On the opening night of the show, Grunion is visited by an agent of the Romanoff family, who threatens to kill him if he does not produce the diamonds in an hour. At the theater, Lefty and the Zoto brothers spy through a window as Maggie puts on the diamond necklace, but Mike asks her not to wear it, promising to buy her an engagement ring instead. As they kiss, Maggie removes the necklace and drops it on the piano strings. The curtain goes up, and when Harpo sees Lefty and the Zoto brothers menacing Maggie, he distracts them with a piece of costume jewelry and leads them up to the roof.Meanwhile, on stage, Faustino plays the piano, and when he strikes the keys forcefully, the diamond necklace flies into the air, drawing the attention of Madame Egelichi, who is watching from the audience. Faustino pockets the diamonds, then rushes to the roof to help Harpo. Madame Egelichi shows up with a gun and demands the necklace, but Faustino gives her the fake diamonds. After tying up Lefty and the Zotos and recovering the real diamonds, Harpo encounters Grunion, who has been hiding on the roof. Harpo drops the diamonds in Grunion 
 Question: Who puts on the diamond necklace?

A:
maggie
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