In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Q: Question: Which of these statements is NOT a characteristic of phase I clinical trials? 
 Options:  <1> They usually have non-therapeutic goals. <2> They can be done in healthy volunteers. <3> They can be done in patients. <4> They are usually randomized. <5> They are usually open.

A: 4
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Q: Question: In glycolysis: 
 Options:  <1> Hexokinase catalyzes the transfer of a phosphate group to different hexoses. <2> Phosphofructokinase-1 catalyzes a reaction that provides ATP. <3> All intermediates are phosphorylated compounds of six carbons. <4> It provides ATP, but it does not use it. <5> Fructose 2,6-bisphosphate is a potent inhibitor.

A: 1
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Q: Question: Woman, 63 years old, in treatment for bone cancer. He has intense pains so he uses morphine daily. Faced with complaints of constipation, it is proposed as a laxative of choice: 
 Options:  <1> Methylcellulose <2> Glycerin. <3> Loperamide. <4> Methylnaltrexone <5> Racecadotril.

A:
4
****