Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Example Input: To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.
Example Output: adverse drug event

Example Input: Type II heparin-induced thrombocytopenia (HIT) is an immunological disorder characterized by antibodies to heparin-platelet factor 4 complexes and a high risk of thrombotic complications.
Example Output: adverse drug event

Example Input: Another approach involves minimal debridement of the cartilage and letting the wound mature for 6 to 8 months.
Example Output:
non-adverse drug event