Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
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Question: Adriamycin-induced cardiomyopathy aggravated by cis-platinum nephrotoxicity requiring dialysis.

Answer: adverse drug event


Question: Niemann-Pick type C is an autosomal-recessive, neurovisceral storage disorder that results from defective cholesterol esterification.

Answer: non-adverse drug event


Question: No severe local side effects were observed.

Answer:
non-adverse drug event