Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

Q: Question: Does the presence of high-grade prostatic intraepithelial neoplasia or atypia on prostate biopsy adversely affect prostatectomy outcomes for patients otherwise eligible for active surveillance?
Answer: The presence of HGPIN or ASAP does not increase the risk of upgrading, upstaging, or adverse pathology at the time of prostatectomy for patients who meet the AS criteria. If otherwise suitable, HGPIN and ASAP should not impact the decision to choose AS. However, analysis of prospective AS trials is required to determine if HGPIN or ASAP impacts tumor progression once on AS.

A: no
****
Q: Question: Is kREX2 essential for either procyclic or bloodstream form Trypanosoma brucei?
Answer: KREX2 is a U-specific exonuclease that is dispensable for RNA editing in vivo in T. brucei BFs and PFs. This result suggests that the U deletion activity, which is required for RNA editing, is primarily mediated in vivo by KREX1 which is normally found associated with only one type of editosome. The retention of the KREX2 gene implies a non-essential role or a role that is essential in other life cycle stages or conditions.

A: no
****
Q: Question: Do beta-blockers before percutaneous coronary intervention attenuate postprocedural creatine kinase isoenzyme rise?
Answer: The results of this large observation study do not support the contention that BB use before PCI decreases myocardial injury.

A:
no
****