Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Newspaper columnist John Klein (Richard Gere) and his wife Mary (Debra Messing) are involved in an accident when Mary swerves to avoid a black, flying figure. John survives the crash unscathed, but Mary is hospitalized. After Mary dies of an unrelated brain tumor, John discovers mysterious drawings of the creature that she had created prior to the night of the accident. Two years later, John becomes lost in West Virginia and inexplicably finds himself in Point Pleasant, hundreds of miles off his route. Driving in the middle of the night, his car breaks down; and he walks to a nearby house to get help. The owner, Gordon Smallwood (Will Patton), reacts violently to John's appearance and holds him at gunpoint. Local police officer Connie Mills (Laura Linney) defuses the situation while Gordon explains that this is the third consecutive night John has knocked on his door asking to use a phone, much to John's confusion. John stays at a local motel and considers how he ended up so far from his original destination. Officer Mills mentions to John that many strange things have been occurring in the past few weeks and that people report seeing a large winged creature like a giant moth with red eyes. She also tells John about a strange dream she had, in which the words "Wake up, Number 37" were spoken to her. While conversing with Gordon one day, it is revealed to John that he had heard voices from his sink telling him that, in Denver, "99 will die". While discussing the day's events at a local diner, John notices that the news is showing a story on an airplane crash in Denver that killed all 99 passengers aboard. The next night, Gordon frantically explains that he had met the voices in his head, a being named Indrid Cold Later that night, Gordon calls John and says that he is standing with a character named Indrid Cold. While John keeps Cold on the line, Officer Mills checks on Gordon. Cold answers John's questions, convincing him that he is a supernatural being. This episode starts a string of supernatural calls to John's motel room. One tells him that there will be a great tragedy on the Ohio River. Later, John receives a call from Gordon and rushes to his home to check on him. He finds Gordon outside, dead from exposure. John becomes obsessed with the being, dubbed Mothman. He meets an expert on the subject, Alexander Leek (Alan Bates), who explains its nature and discourages John from becoming further involved. However, when John learns the governor (Murphy Dunne) plans to tour a chemical plant located on the Ohio River the following day, he becomes convinced the tragedy will occur there. Officer Mills and the governor ignore his warnings, and nothing happens during the tour. Soon afterwards, John receives a mysterious message that instructs him to await a call from his deceased wife Mary back in Georgetown, and he returns home. On Christmas Eve, Officer Mills calls and convinces him to ignore the phone call from "Mary", return to Point Pleasant, and join her. Though anguished, John agrees. As John reaches the Silver Bridge, a malfunctioning traffic light causes traffic congestion. As John walks onto the bridge to investigate, the bolts and supports of the bridge strain. The bridge comes apart, and John realizes that the prophesied tragedy on the Ohio River was about the bridge. As the bridge collapses, Officer Mills's car falls into the water. John jumps in after her and pulls her from the river and up to safety. As the two sit on the back of an ambulance, they see that 36 people have been killed, making Connie the "number 37" from her dream. The epilogue displays a series of graphics that state the cause of the bridge collapse was never fully determined. It also states that, although the Mothman has been sighted in other parts of the world, it was never seen again in Point Pleasant.

Answer: Who is John's wife?


Question: Ian Lafferty (Josh Zuckerman) is an 18-year-old recent high school graduate. He searches for a girl online making it seem as if he is attractive and strong, although he's sweet and unassuming. He soon meets "Ms. Tasty" (Katrina Bowden) and agrees to meet her in person. She lives in Knoxville, Tennessee, while he lives in Chicago, Illinois. With his best friends Lance Nesbitt (Clark Duke) and Felicia Alpine (Amanda Crew), he goes to Knoxville in a 1969 Pontiac GTO Judge borrowed without permission from Ian's arrogant homophobic older brother Rex (James Marsden). On the way to Knoxville, they come across a hitchhiker (David Koechner), as the radiator in the Judge overheats. They attempt urinating in the radiator, which only works briefly as they try to leave the hitchhiker in the dust. The hitchhiker, frustrated at Ian's lack of concern for his well being, leaves, but not before urinating on the car window. As Ian and Felicia wander to find help, Lance is waiting with the car as Ezekiel (Seth Green) happens to pass by in his horse-drawn buggy. Ezekiel and his Amish buddies repair the car while they join a Rumspringa party where Fall Out Boy are playing a concert, and at which Lance meets an attractive Amish girl, Mary (Alice Greczyn). The three promise to come again on the way back to do some work in return for fixing the car. They go to jail due to Ian throwing a tire iron into a state trooper car, due to his increasing frustration after trying to put a possum he hit out of its misery, and are released after Mary pays the bail. Upon arriving at Knoxville, they find a hotel that sports a wide variety of role playing rooms. Rex, who has discovered the Judge gone missing, arrives angrily and insists that they go back and that Ian cannot visit Ms. Tasty. After Ian pretends to be gay, Rex allows him to see Ms. Tasty, hoping this encounter will change Ian's mind. Ian finally meets Ms. Tasty. However, when he tells her about Felicia, her seduction for Ian to take off his clothes becomes a threat as her psychotic boyfriend Bobby Jo (Dave Sheridan) puts a gun to Ian's head. It becomes apparent that they work at a chop shop and attempt to steal the Judge. Lance and Mary arrive after having sex, as well as a redneck named Rick (Michael Cudlitz) whose girlfriend Brandy (Andrea Anders) slept with Lance earlier. Felicia, however, is hiding in the car when Bobby Jo tries to steal it. Soon, a green car that has been continuously drag-racing with the Judge throughout the movie arrives. Ian manages to save Felicia, who then is able to run off and report to the police. Ms. Tasty tries to escape, but is stopped by the green car, whose drivers turn out to be Andy and Randy (Charlie McDermott and Mark L. Young), two dim-witted self-declared "womanizers" from Ian's school, who Ms. Tasty tried to manipulate into giving her the car. Bobby Jo is treated after being shot by Ian in self-defense. Felicia tells the police about the chop shop location and the couple is arrested. Upon finding out that if Mary leaves the Amish community, she will be shunned, Lance refuses to come back home and stays behind to marry Mary, while Ian and Felicia realize their love for each other. Ian and Felicia drive to a tree where Ian throws his shoes up into the tree. A few weeks later Ian is Felicia's date to her cousin's wedding. At Thanksgiving dinner, Rex tells his family that he's gay. On New Year's Eve Ian and Felicia finally have sex, in Ian's basement under a blanket on the sofa. In the final frame of the film, a picture is shown of Lance and Mary getting married, accompanied by Ian. Lance is shown sporting a beard exactly like Ezekiel's. During the credits, a short scene is shown of Ezekiel and Fall Out Boy arguing over the fact that the

Answer: Who does Ian shoot?


Question: Deletions of the proximal long arm of chromosome 15 (bands 15q11q13) are found in the majority of patients with two distinct genetic disorders, Angelman syndrome (AS) and Prader-Willi syndrome (PWS). The deleted regions in the two syndromes, defined cytogenetically and by using cloned DNA probes, are similar. However, deletions in AS occur on the maternally inherited chromosome 15, and deletions in PWS occur on the paternally derived chromosome 15. This observation has led to the suggestion that one or more genes in this region show differential expression dependent on parental origin (genetic imprinting). No genes of known function have previously been mapped to this region. We show here that the gene encoding the GABAA (gamma-aminobutyric acid) receptor beta 3 subunit maps to the AS/PWS region. Deletion of this gene (GABRB3) was found in AS and PWS patients with interstitial cytogenetic deletions. Evidence of beta 3 gene deletion was also found in an AS patient with an unbalanced 13;15 translocation but not in a PWS patient with an unbalanced 9;15 translocation. The localization of this receptor gene to the AS/PWS region suggests a possible role of the inhibitory neurotransmitter GABA in the pathogenesis of one or both of these syndromes.

Answer:
Angelman syndrome is associated with deletion of a part of Chromosome 15 but if the deletion occurs in the paternally inherited chromosome 15, what is the disease?