instruction:
In this task, you are given a sentence. You are expected to recognize the name of gene or protein. Although there might be several correct answers, you need to write one of them.
question:
 We describe a novel and potentially important mechanism of nitric oxide signaling - through direct activation of guanine nucleotide - binding proteins ( G proteins ) .
answer:
G proteins


question:
 This approach has the potential advantage of suppressing the expression of various proinflammatory Th2 cytokines simultaneously rather than suppressing the activity of a single cytokine .
answer:
proinflammatory Th2 cytokines


question:
 Investigation of mast cell responsiveness toward retinoic acid ( RA ) revealed selective promotion of ICAM - 3 expression in the human mast cell line HMC - 1 .
answer:

ICAM - 3