Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

The blockage of transcription elongation by RNA polymerase II (pol II) at a DNA damage site on the transcribed strand triggers a transcription-coupled DNA repair (TCR), which rapidly removes DNA damage on the transcribed strand of the expressed gene and allows the resumption of transcription. To analyze the effect of UV-induced DNA damage on transcription elongation, an in vitro transcription elongation system using pol II and oligo(dC)-tailed templates containing a cyclobutane pyrimidine dimer (CPD) or 6-4 photoproduct (6-4PP) at a specific site was employed. The results showed that pol II incorporated nucleotides opposite the CPD and 6-4PP and then stalled. Pol II formed a stable ternary complex consisting of pol II, the DNA damage template, and the nascent transcript. Furthermore, atomic force microscopy imaging revealed that pol II stalled at the damaged region. These findings may provide the basis for analysis of the initiation step of TCR.
Which gene strand is targeted by transcription-coupled repair (TCR)?

The Godfather Part II presents two parallel storylines. One involves Mafia chief Michael Corleone in 1958/1959 after the events of the first movie; the other is a series of flashbacks following his father, Vito Corleone from 1917 to 1925, from his youth in Sicily (1901) to the founding of the Corleone family in New York.The film begins in 1901, in the town of Corleone, Sicily, at the funeral of young Vito's father, Antonio Andolini, who has been murdered for an insult to the local Mafia lord, Don Ciccio. During the procession, Vito's older brother is murdered because he swore revenge on the Don. Vito's mother goes to Ciccio to beg for mercy, but he refuses, knowing that nine-year-old Vito will seek revenge later in life. The mother takes Ciccio hostage at knifepoint, allowing her son to escape, and Ciccio's men kill her. They search the town for the boy, but he is aided in his escape by the townspeople. Vito finds his way by ship to New York, and at Ellis Island an immigration agent chooses Vito's hometown of Corleone as his surname, and he is registered as "Vito Corleone".In 1958 in a scene similar to the opening of the first film, Michael Corleone (Al Pacino), Godfather of the Corleone family, deals with various business and family problems during an elaborate party at his Lake Tahoe, Nevada compound to celebrate his son's First Communion. In his office, Michael meets with corrupt Nevada Senator Pat Geary (G. D. Spradlin) to discuss the price of the gaming licenses for the hotel/casinos the Family is buying. Geary, who has obvious contempt for Michael and other Italian businessmen who are moving into his state to take advantage of gambling opportunities, promises to make Michael's acquisition of his gaming license a difficult process. Michael ends his conversation with Geary when he refuses to pay the outrageous fee Geary demands, telling the senator he'll get nothing.Michael also deals with his self-indulgent younger sister Connie (Talia Shire), who, although recently divorced from her second husband, is planning to marry a man named Merl Johnson (Troy Donahue) with no obvious means of support and of whom Michael disapproves. He also talks with Johnny Ola (Dominic Chianese), the right hand man of Jewish gangster Hyman Roth (Lee Strasberg), who is supporting Michael's move into the gambling industry. Belatedly, Michael deals with Frank "Five Angels" Pentangeli (Michael V. Gazzo), a business associate who took over Corleone caporegime Peter Clemenza's territory in New York City after his death, and now has problems with the Rosato Brothers, who are backed by Roth. Pentangeli leaves abruptly, after telling Michael "your father did business with Hyman Roth, your father respected Hyman Roth, but your father never trusted Hyman Roth."Later that night, Michael barely escapes an assassination attempt when his wife Kay (Diane Keaton) notices the bedroom window drapes are inexplicably open, which allows two unseen hitmen to spray the bedroom with bullets. The two hitman are found dead having been killed by a "mole" within the compound. Afterwards, Michael tells his lawyer and associate Tom Hagen (Robert Duvall) that the hit was made with the help of someone close, and that he must leave, entrusting all his power to Hagen to protect his family.Flashback: In 1917 New York City, the adult Vito Corleone (Robert De Niro) works in a grocery store in the Lower East side with his friend Genco Abbandando. The neighborhood is controlled by a member of the "The Black Hand," Don Fanucci (Gastone Moschin), who extorts protection payments from local businesses. One night, Vito's neighbor Clemenza (Bruno Kirby) asks him to hide a stash of guns for him, and later, to repay the favor, takes him to a fancy apartment where they commit their first felony together, stealing an elegant rug.The film flash-forwards to Michael's time. Michael meets with poushal Hyman Roth in Miami, Florida who tells Michael that he believes Frank Pentangeli was responsible for the assassination attempt, and that Pentangeli will pay for it
who  denies  previous statements ?

High circulating levels of group IIA secretory phospholipase A2 (sPLA2-IIA) activity and mass are independent cardiovascular risk factors. Therefore, inhibition of sPLA2-IIA may be a target for the treatment of atherosclerotic cardiovascular disease. The present study evaluated the effects of sPLA2-IIA inhibition with varespladib acid in a novel mouse model, human apolipoprotein B (apoB)/human cholesteryl ester transfer protein (CETP)/human sPLA2-IIA triple transgenic mice (TTT) fed a Western-type diet. sPLA2-IIA expression increased atherosclerotic lesion formation in TTT compared with human apoB/human CETP double transgenic mice (P<0.01). Varespladib acid effectively inhibited plasma sPLA2-IIA activity. Surprisingly, however, administration of varespladib acid to TTT had no impact on atherosclerosis, which could be attributed to a proatherogenic plasma lipoprotein profile that appears in response to sPLA2-IIA inhibition because of increased plasma CETP activity. In the TTT model, sPLA2-IIA decreased CETP activity by reducing the acceptor properties of sPLA2-IIA-modified very low-density lipoproteins specifically because of a significantly lower apoE content. Increasing very low-density lipoprotein-apoE content by means of adenovirus-mediated gene transfer in sPLA2-IIA transgenic mice restored the acceptor properties for CETP. These data show that in a humanized triple transgenic mouse model with hypercholesterolemia, sPLA2-IIA inhibition increases CETP activity via increasing the very low-density lipoprotein-apoE content, resulting in a proatherogenic lipoprotein profile.

Which enzyme is inhibited by Varespladib?