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A few years ago he began working with Dr. Jenny Chang  medical director of the Lester and Sue Smith Breast Center at Baylor College of Medicine.
 Chang had performed a number of biopsies on breast cancer patients  both on those whose cancers were confined to the breast and on those whose cancers had metastasized to the brain.
 From those biopsies  Chang said she had identified a number of genetic pathways ways in which gene mutations affected the ability of the cancer to spread unique to patients who developed metastatic breast cancer.
 "But I had a lot of trouble with the data and trying to translate it into clinical practice " she said. She couldn't find her way out from beneath the avalanche of data.
 So she turned to Wong.
 Using his mathematical modeling  Wong sifted through Chang's data and the large databases of genome and clinical trial data. Out of that  he identified several candidate drugs to impair the genetic pathways that helped the cancer spread.
Chang's data and the large databases of genome and clinical trial data. Out of that  he identified several candidate drugs to impair the genetic pathways that helped the cancer spread.
 One of them  a drug named sunitinib  which treats a kidney cancer called renal cell carcinoma  emerged as the best bet. Chang then tested the drug in mice  and the study showed it prevented breast cancer from spreading to the brain.
 She has already begun a Phase II clinical trial of the drug  enrolling nine patients with metastatic breast cancer  and she is looking for more.
 "The drug is very well-tolerated by patients  and so far the trial is going very well " Chang said.
 But by using an existing drug  Chang and Wong could skip the lengthy Phase I  during which a drug is checked for safety. If Chang's tests go well  sunitinib could be on the market within a few years for metastatic breast cancer.
IN OLD DRUGS RESEARCHER LOOKS FOR NEW TREATMENTS

Matanga Hill offers the best Hampi vantage point.  Darshini Kandasamy
Chosen by King Harihara  as  his  capital in 1336  Hampi grew in grandeur  wealth and power until  its  fall to the Deccan sultanates confederacy in 1565  after which  it  was razed  plundered and eventually abandoned.
Hampi was part of the mighty Vijayanagara Empire in the 1300s. Darshini Kandasamy
The ride to Hampi is bumpy yet scenic. Darshini Kandasamy
Discovering the majesty of Hampi can easily take a few days. Darshini Kandasamy
Hampi guide M. D. Basava was born and raised in the area. Darshini Kandasamy
Hampi India: Ancient city of gods kings and ruins

We have some news now on how the Trump administration is pushing back against illegal immigration. The administration has for months talked about separating immigrant families at the border as a way of discouraging them from coming in the first place. A federal lawsuit filed on Monday says federal agents are increasingly doing that  and the idea has outraged activists. The plaintiff is an undocumented Congolese woman who's being detained in San Diego while her 7-year-old daughter is being held 2 000 miles away at a shelter in Chicago.  NPR's John Burnett  has the story.
 JOHN BURNETT   BYLINE: In recent years  the Department of Homeland Security has attempted to discourage asylum-seekers from coming to the U.S. Under Obama  they detained some unauthorized families in camps in South Texas rather than release them in the U.S. while their cases are heard. The Trump administration has gone even further. It has arrested immigrant parents in the U.S. who paid smugglers to bring their children across the border  and it wants to expand detention space. Now comes the most extreme measure yet  family separation.
 BURNETT : That's Lee Gelernt  deputy director of the ACLU's National Immigrant Rights Project. He's representing a 39-year-old mother who traveled from the Democratic Republic of Congo to Mexico with her 7-year-old daughter. They surrendered to immigration agents near San Diego in December. They said they were fleeing violence in Congo and asked for asylum. She's being held apart from her daughter. They're only able to speak by phone.
 BURNETT : A spokeswoman for Homeland Security declined to give a reason why the child was taken from her mother  saying only the agency does not comment on cases under litigation. The practice of separating undocumented families to discourage them from coming is not a formal stated policy of the administration  but immigrant activists say it's been quietly growing in frequency along the Southern border. Katharina Obser is with the Women's Refugee Commission.
 BURNETT : Lutheran Immigration and Refugee Services has documented 53 incidents of family separation in the last nine months  mostly Central Americans. They say they're fleeing rampant gang violence. But the administration believes most of them are gaming the system  and it wants to stop the flow  first  because the trek is dangerous for young children. And  second  Matt Al Bent's  an official with ICE removal operations  told NPR...
 BURNETT : Immigration lawyers say the strategy could work. Mothers may drop their cases and go home to be reunited with their children. But is that a reasonable way to curtail illegal immigration? Dr. Lisa Fortuna  director of Child and Adolescent Psychiatry at the Boston Medical Center  is an expert on the impact of trauma on immigrant families. She's submitting an amicus brief in the ACLU lawsuit.
 BURNETT : The lawsuit claims that immigration agents violated the Congolese woman's constitutional right to due process. It asks the government  if it's going to detain a mother and child during the asylum process  at least allow them to be together.  John Burnett   NPR News. Transcript provided by NPR  Copyright NPR.

To Curb Illegal Immigration DHS Separating Families At The Border