Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: Ca2+ is a ubiquitous intracellular messenger responsible for controlling numerous cellular processes including fertilization, mitosis, neuronal transmission, contraction and relaxation of muscles, gene transcription, and cell death. At rest, the cytoplasmic Ca2+ concentration [Ca2+]i is approximately 100 nM, but this level rises to 500-1,000 nM upon activation. In osteoblasts, the elevation of [Ca2+]i is a result of an increase in the release of Ca2+ from endoplasmic reticulum and/or extracellular Ca2+ influx through voltage gated Ca2+ channels. Many of the cellular effects of Ca2+ are mediated by the Ca2+ binding protein, calmodulin (CaM). Upon binding up to four calcium ions, CaM undergoes a conformational change, which enables it to bind to specific proteins eliciting a specific response. Calmodulin kinase II (CaMKII) is a major target of the Ca(2+)/CaM second messenger system. Once bound to Ca(2+)/CaM, the multimeric CaMKII is released from its autoinhibitory status and maximally activated, which then leads to an intraholoenzyme autophosphorylation reaction. Calcineurin (Cn) is another major target protein that is activated by Ca(2+)/CaM. Cn is a serine-threonine phosphatase that consists of a heterodimeric protein complex composed of a catalytic subunit (CnA) and a regulatory subunit (CnB). Upon activation, Cn directly binds to, and dephosphorylates nuclear factor of activated T cells (NFAT) transcription factors within the cytoplasm allowing them to translocate to the nucleus and participate in the regulation of gene expression. This review will examine the potential mechanisms by which calcium, CaM, CaMKII, and Cn/NFAT control osteoblast proliferation and differentiation. 
 Question: Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)?
can

Context: FreeBSD is a free Unix-like operating system descended from Research Unix via the Berkeley Software Distribution (BSD). 
 Question: The FreeBSD is based upon what?
berkeley software distribution

Context: Shirley Temple Black, who lifted America's spirit as a bright-eyed child movie star during the Great Depression, peacefully passed away at her California home on Monday evening at 85, surrounded by her family and caregivers. Temple, born on April 23, 1928, started her entertainment career in the early 1930s and was famous by age 6. Temple was 3 when her mother put her in dance school, where a talent scout spotted her and got her in Baby Burlesks, a series of short movies with child actors playing in adult movies. Movie studio directors took notice of her and in 1934 she appeared in the film Stand Up and Cheer! and her song and dance caught people's attention. Movies such as Little Miss Marker and Bright Eyes featured her signature song. In 1935, she received a special Oscar for her "outstanding contribution to screen entertainment" in the movie Stand Up and Cheer! She made some 40 feature movies, including The Little Colonel, Poor Little Rich Girl, Heidi and Rebecca of Sunnybrook Farm, in 10 years, starring with big-name actors like Randolph Scott, Lionel Barrymore and Jimmy Durante. Temple was a superstar before the term was invented. She said she was about 8 when crowds shouting their love for her made her realize she was famous. "I wondered why," she recalled. "I asked my mother and she said, 'Because your films make them happy.' " Her child career came to an end at 12. She tried a few roles as a teenager--including opposite future president Ronald Reagan in That Hagen Girl - but retired from the screen in 1949 at 21. Temple was only 17 when she married for the first time to John Agar, who would eventually appear with her in two movies. Their five-year marriage produced a daughter. In 1950 she wed Charles Black in a marriage that lasted until his death in 2005. She and Black had two children. Temple's interest in politics was sparked in the early 1950s when her husband was called back into the Navy to work in Washington. 
 Question: For which movie did Shirley Temple win the Oscar?

stand up and cheer