Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
The translocation (9;22) gives rise to the p190(Bcr-Abl) and p210(Bcr-Abl) tyrosine kinase proteins, considered sufficient for leukemic transformation. Philadelphia-positive (Ph(+)) acute leukemia patients failing to respond to initial induction therapy have a poor prognosis with few effective treatment options. Imatinib is an orally administered, potent inhibitor of the Bcr-Abl tyrosine kinase. We conducted a clinical trial in 56 patients with relapsed or refractory Ph(+) acute lymphoblastic leukemia (ALL; 48 patients) or chronic myelogenous leukemia in lymphoid blast crisis (LyBC; 8 patients). Imatinib was given once daily at 400 mg or 600 mg. Imatinib induced complete hematologic responses (CHRs) and complete marrow responses (marrow-CRs) in 29% of ALL patients (CHR, 19%; marrow-CR, 10%), which were sustained for at least 4 weeks in 6% of patients. Median estimated time to progression and overall survival for ALL patients were 2.2 and 4.9 months, respectively. CHRs were reported for 3 (38%) of the patients with LyBC (one sustained CHR). Grade 3 or 4 treatment-related nonhematologic toxicity was reported for 9% of patients; none of the patients discontinued therapy because of nonhematologic adverse reactions. Grade 4 neutropenia and thrombocytopenia occurred in 54% and 27% of patients, respectively. Imatinib therapy resulted in a clinically relevant hematologic response rate in relapsed or refractory Ph(+) acute lymphoid leukemia patients, but development of resistance and subsequent disease progression were rapid. Further studies are warranted to test the effects of imatinib in combination with other agents and to define the mechanisms of resistance to imatinib.

Ex Output:
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Ex Input:
Founded in Paris by Marco Tinelli in 1998 under the name Grey Interactive, over the past 15 years the digital agency has become an integrated communications group composed of 20 agencies around Europe and in 8 different countries (France, Spain, Portugal, Italy, United Kingdom, Germany, U.S. and China) FullSIX Group has 10 agency networks:

Ex Output:
In what city is FullSIX based?


Ex Input:
Lighter and cheaper than high-quality video cameras, today's best smartphones can shoot and edit high-definition (HD) videos. With lower-quality lenses and image sensors, smartphones probably won't replace professional video cameras anytime soon. Still, some creative filmmakers are extending the borders of smartphone moviemaking by shooting professional-quality films using only smartphones. Soon after Apple's iPhone 4 was released, two filmmakers decided to make a short film using only their iPhone 4s. Michael Koerbel and Anna Elizabeth James shot and edited the one-and-a-half-minute film Apple of My Eye in only 48 hours. Audiences were fascinated with the film, in which a man and his grandfather connect emotionally while admiring a model train set in a store window. The filmmakers followed up their success with Goldilocks, an extraordinary spy novel told over nine, three-minute films. Many filmmakers are convinced that smartphone films are here to stay. One sign is their inclusion in major film festivals. In February 2012, organizers of the Berkshire International Film Festival staged the 10 X 10 On North Festival. Entries included Oliver by Hooman Khalili, an award-winning film about a girl whose special powers enable her to brighten the lives of three lonely people. Another entry was Yearlapse'11, a 365-second film by Zsolt Haraszti that describes an actual journey he made from New York to London. During the festival, which ran from February 16 to 26, these and many other smartphone films were shown at the Beacon Cinema in Pittsfield, Massachusetts. Similar festivals in Canada and South Korea have given smartphone filmmakers opportunities to show off their creative work.

Ex Output:

Which film is about secret agents?