TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: The dodo is among the most famous extinct creatures, and _ for human-caused extinction events. Despite its bad name, and the fact that the species was alive during recorded human history, little is actually known about how this animal lived, looked, and behaved. A new study of the only known complete skeleton from a single bird takes advantage of modern 3-D laser scanning technology to open a new window into the life of this famous extinct bird. The study was presented at the 74th Annual Meeting of the Society of Vertebrate Paleontology in Estrel, Berlin. Leon Claessens, Associate Professor at the College of the Holy Cross, and lead researcher on the study said that, "the 3-D laser surface scans we made of the fragile dodo skeletons enable us to reconstruct how the dodo walked, moved and lived to a level of detail that has never been possible before. There are so many outstanding questions about the dodo bird that we can answer with this new knowledge." A complete dodo skeleton, found by an amateur collector and barber, Etienne Thirioux, on the island of Mauritius between 1899 and 1917, has remained unstudied, even though it is the only complete dodo skeleton from a single individual bird known to exist. All other skeletons are incomplete combinations, meaning that they are gathered from more than one individual. In addition, Thirioux constructed a second, partially combined skeleton, which contains many bones that also belong to a single bird. "Being able to examine the skeleton of a single, individual dodo, which is not made up from as many individual birds as there are bones, as is the case in all those other combined skeletons, truly allows us to appreciate the way the dodo looked and see how tall or fat it really was," said Juilan Hume, of the Natural History Museum UK, a co-author on the study. The scans were performed on site in Durban, South Africa, and allow examination of the biology of this mysterious extinct bird in detail for the first time. Using the newest digital tools and techniques, the scans provide an insight into how the flightless dodo may have developed its giant size, and how it walked and lived in its forest home. According to Kenneth Rijsdijk, a biologist from University of Amsterdam, "the skull of the dodo is so large and its mouth so strong that it is easy to understand that the earliest naturalists thought it was related to sharks and other birds of prey , rather than the pigeon family."

SOLUTION: What is special about the dodo skeleton found by an amateur collector?

PROBLEM: Protein kinases (PKs) and lipid kinases (LKs) are good choices for targets of signal transduction therapy as these enzymes are involved in signaling pathways, and are often related to the pathogenesis of lymphoid malignancies. The attractiveness of PKs and LKs as drug able targets is enhanced by the fact that they are enzymes whose biological activity can be turned off by drugs that block their catalytic site. In the last few years small molecular kinase inhibitors (KIs) have been synthesized and become available for preclinical studies and clinical trials. The first KI, introduced into clinical practice in 1998, was imatinib mesylate, which became the first choice drug in chronic myeloid leukemia. More recently, several KIs have been developed to target the proximal B-cell receptor (BCR) signaling pathway including spleen tyrosine kinase inhibitor (Fostamatinib) and Bruton's tyrosine kinase inhibitors (Ibrutinib, AVL-263). These agents are currently evaluated in early clinical trials in chronic lymphocytic leukemia (CLL) and other diseases. Cyclin-dependent kinase (Cdk) inhibitors, flavopiridol (alvocidib), BMS-387032 (SNS-032), sunitinib and sorafenib are currently under evaluation in clinical trials for relapsed/refractory CLL. Multi-tyrosine kinase inhibitors including vandetanib (ZD6474) bosutinib (SKI-606), TKI258 (CHIR-258), pazopanib (GW786034) and axitinib (AG013736) have been also developed for the treatment of lymphoid malignancies. Phosphatidylinositol 3-kinases (PI3K ) are a family of lipid kinases that mediate signals from cell surface receptors. CAL-101 (GS-1101) is an oral PI3K-specific inhibitor which has shown preclinical and clinical activity against CLL. This article summarizes recent achievements in the mechanism of action, pharmacological properties and clinical activity and toxicity of PK and LK inhibitors in CLL.

SOLUTION: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?

PROBLEM: September 1939. Mrs. Kay Miniver (Greer Garson) and her family live a comfortable life at a house called 'Starlings' in Belham, a fictional village outside London, England. The house has a large garden, with a private landing stage on the River Thames at which is moored a motorboat belonging to her devoted husband Clem (Walter Pidgeon), a successful architect. They have three children: the youngsters Toby and Judy (Christopher Severn and Clare Sandars) and an older son Vin (Richard Ney) at university. They have live-in staff: Gladys the housemaid (Brenda Forbes) and Ada the cook (Marie De Becker).As World War II looms, Vin comes down from university and meets Carol Beldon (Teresa Wright), granddaughter of Lady Beldon (Dame May Whitty) from nearby Beldon Hall. Despite initial disagreements (mainly contrasting Vin's idealistic attitude to class differences with Carol's practical altruism) they fall in love. Vin proposes to Carol in front of his family at home after his younger brother prods him to give a less romantic but more honest proposal.Several months later, as the war comes closer to home with the bombing of Great Brittan, Vin feels he must "do his bit" and enlists in the Royal Air Force, qualifying as a fighter pilot. He is posted to a base near to his parents' home and is able to signal his safe return from operations to his parents by cutting his engines briefly as he flies over the house. Together with other boat owners, Clem volunteers to take his motorboat to assist in the May-June 1940 Dunkirk evacuation.Early one morning, Kay unable to sleep as Clem is still away, wanders down to the landing stage. She is startled to discover a wounded German pilot (Helmut Dantine) hiding in her garden and he holds her at gunpoint. Demanding food and a coat, the pilot maniacally asserts that the Third Reich will mercilessly overcome its enemies. She feeds him, calmly disarms him and then calls the police. Soon after, Clem returns home, exhausted, from Dunkirk.Lady Beldon visits Kay to try and convince her to talk Vin out of marrying Carol on account of her granddaughter's comparative youth. Lady Beldon is unsuccessful and admits defeat when Kay reminds her that she, too, was young when she married her late husband. Lady Beldon concedes defeat and realises that she would be foolish to try and stop the marriage. Vin and Carol are married; Carol has now also become Mrs Miniver, and they return from their honeymoon in Scotland. A key theme is that she knows he is likely to be killed in action, but the short love will fill her life. Later, Kay and her family take refuge in their Anderson shelter in the garden during an air raid, and attempt to keep their minds off the frightening bombing by reading Alice's Adventures in Wonderland, which Clem refers to as a "lovely story" as they barely survive a bomb destroys parts of the house. They take the damage with nonchalance.At the annual village flower show, Lady Beldon silently disregards the judges' decision that her rose is the winner, instead announcing the entry of the local stationmaster, Mr. Ballard (Henry Travers), named the "Mrs. Miniver" rose, as the winner, with her own rose taking second prize. As air raid sirens sound and the villagers take refuge in the cellars of Beldon Hall, Kay and Carol drive Vin to join his squadron. On their journey home they witness fighter planes in a 'dogfight'. For safety, Kay stops the car and they see the German plane crash. Kay realises Carol has been wounded by shots from the plane and takes her back to 'Starlings'. She dies a few minutes after they reach home. Kay is devastated. When Vin returns from battle, he already knows the terrible news. Unexpectedly he is the survivor, and she the one who gives her life for England.The villagers assemble at the badly damaged church where their vicar (Henry Wilcoxon) affirms their determination in a powerful sermon:"We in this quiet corner of England have suffered the loss of friends very dear to us, some

SOLUTION:
Who dies after sustaining wounds caused by the plane shots?