Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: D0g is a fictional character in the Half-Life series of video games, first introduced in Half-Life 2 in 2004.

Output: What fictional work does D0g exist in?


Input: Consider Input: The dodo is among the most famous extinct creatures, and _ for human-caused extinction events. Despite its bad name, and the fact that the species was alive during recorded human history, little is actually known about how this animal lived, looked, and behaved. A new study of the only known complete skeleton from a single bird takes advantage of modern 3-D laser scanning technology to open a new window into the life of this famous extinct bird. The study was presented at the 74th Annual Meeting of the Society of Vertebrate Paleontology in Estrel, Berlin. Leon Claessens, Associate Professor at the College of the Holy Cross, and lead researcher on the study said that, "the 3-D laser surface scans we made of the fragile dodo skeletons enable us to reconstruct how the dodo walked, moved and lived to a level of detail that has never been possible before. There are so many outstanding questions about the dodo bird that we can answer with this new knowledge." A complete dodo skeleton, found by an amateur collector and barber, Etienne Thirioux, on the island of Mauritius between 1899 and 1917, has remained unstudied, even though it is the only complete dodo skeleton from a single individual bird known to exist. All other skeletons are incomplete combinations, meaning that they are gathered from more than one individual. In addition, Thirioux constructed a second, partially combined skeleton, which contains many bones that also belong to a single bird. "Being able to examine the skeleton of a single, individual dodo, which is not made up from as many individual birds as there are bones, as is the case in all those other combined skeletons, truly allows us to appreciate the way the dodo looked and see how tall or fat it really was," said Juilan Hume, of the Natural History Museum UK, a co-author on the study. The scans were performed on site in Durban, South Africa, and allow examination of the biology of this mysterious extinct bird in detail for the first time. Using the newest digital tools and techniques, the scans provide an insight into how the flightless dodo may have developed its giant size, and how it walked and lived in its forest home. According to Kenneth Rijsdijk, a biologist from University of Amsterdam, "the skull of the dodo is so large and its mouth so strong that it is easy to understand that the earliest naturalists thought it was related to sharks and other birds of prey , rather than the pigeon family."

Output: What is special about the dodo skeleton found by an amateur collector?


Input: Consider Input: To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. Male Lewis rats underwent MMT surgery and were treated weekly with tanezumab (0.1, 1 or 10mg/kg), isotype control or vehicle for 7, 14 or 28days. Gait deficiency was measured to assess weight-bearing on the operated limb. Joint damage was assessed via histopathology. A second arm, delayed onset of treatment (starting 3-8weeks after MMT surgery) was used to control for analgesia early in the disease process. A third arm, mid-tibial amputation, evaluated the dependency of the model on weight-bearing. Gait deficiency in untreated rats was present 3-7days after MMT surgery, with a return to normal weight-bearing by days 14-28. Prophylactic treatment with tanezumab prevented gait deficiency and resulted in more severe cartilage damage. When onset of treatment with tanezumab was delayed to 3-8weeks after MMT surgery, there was no increase in cartilage damage. Mid-tibial amputation completely prevented cartilage damage in untreated MMT rats. These data suggest that analgesia due to NGF inhibition during the acute injury phase is responsible for increased voluntary weight-bearing and subsequent cartilage damage in the rat MMT model. This model failed to replicate the hypotrophic bone response observed in tanezumab-treated patients with RPOA.


Output: What is the target of tanezumab?