In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Q: Paragraph: CD133 (prominin-1), a 5-transmembrane glycoprotein, has recently been considered to be an important marker that represents the subset population of cancer stem-like cells. Herein we report the isolation of CD133-positive cells (LC-CD133 + ) and CD133-negative cells (LC-CD133 2 ) from tissue samples of ten patients with non-small cell lung cancer (LC) and five LC cell lines. LC-CD133 + displayed higher Oct-4 expressions with the ability to self-renew and may represent a reservoir with proliferative potential for generating lung cancer cells. Furthermore, LC-CD133 + , unlike LC-CD133 2 , highly coexpressed the multiple drug-resistant marker ABCG2 and showed significant resistance to chemotherapy agents (i.e., cisplatin, etoposide, doxorubicin, and paclitaxel) and radiotherapy. The treatment of Oct-4 siRNA with lentiviral vector can specifically block the capability of LC-CD133 + to form spheres and can further facilitate LC-CD133 + to differentiate into LC-CD133 2 . In addition, knock-down of Oct-4 expression in LC-CD133 + can significantly inhibit the abilities of tumor invasion and colony formation, and increase apoptotic activities of caspase 3 and poly (ADP-ribose) polymerase (PARP). Finally, in vitro and in vivo studies further confirm that the treatment effect of chemoradiotherapy for LC-CD133 + can be improved by the treatment of Oct-4 siRNA. In conclusion, we demonstrated that Oct-4 expression plays a crucial role in maintaining the self-renewing, cancer stem-like, and chemoradioresistant properties of LC-CD133 + . Future research is warranted regarding the up-regulated expression of Oct-4 in LC-CD133 + and malignant lung cancer. 
 Title: Oct-4 Expression Maintained Cancer Stem-Like Properties in Lung Cancer-Derived CD133-Positive Cells

A: True
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Q: Paragraph: Cape 7535, South Africa; E-Mails: rmcbride@uwc.ac.za (R.M.); 2917799@myuwc.ac.za (M.Z.) † These authors contributed equally to this work. Abstract: The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multifunctional protein. The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions of the protein. 
 Title: The Coronavirus Nucleocapsid Is a Multifunctional Protein

A: False
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Q: Paragraph: Potent effective antiviral drugs recently have been licensed for several viral diseases, ushering in a new era in the treatment of viral diseases. At the same time, we have seen widespread adoption of rapid diagnostic tests to identify specific viral etiologies. These developments bring us to a point where the diagnosis and effective treatment of many viral diseases are commonplace. Several antiviral agents and their targets will be examined in this review. Acyclovir is effective against herpes simplex virus and varicella zoster virus; ribavirin, recently introduced, is effective against respiratory syncytial virus; amantadine is effective against the influenza type A viruses. Anticytomegalovirus agents, antihuman immunodeficiency virus agents, and immunomodulators such as the interferons are under investigation. Older agents such as adenosine arabinoside and idoxuridine are being replaced by newer, more effective agents. It has taken us a long time to reach this point because rendering a virus inactive is a more formidable feat than killing a bacteria. Bacteria reproduce outside of human cells and have several unique features that distinguish them from human cells. Viruses, in contrast, reproduce within human cells and have fewer unique features that selectively can be inhibited. 36 In recent years, several unique features in the process of a viral infection have been identified as target points for interference or inhibition. These unique steps in the process and the interfering compounds are the subject of this review. Acyclovir (Zovirax) currently is the most effective agent against several herpesviruses. It is a synthetic acyclic purine (guanosine) nucleoside ana- 
 Title: Antiviral Agents

A:
True
****