TASK DEFINITION: Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.
PROBLEM: Paragraph: Such a test could initially be used to select patients for clinical trials of experimental treatments being developed to try to halt progression of Alzheimer’s, the researchers said, and may one day move into routine use in doctors’ clinics. “Alzheimer’s begins to affect the brain many years before patients are diagnosed (and) many of our drug trials fail because by the time patients are given the drugs the brain has already been too severely affected,” said Simon Lovestone of Oxford University, who led this work from King’s College London. “A simple blood test could help us identify patients at a much earlier stage to take part in new trials and hopefully develop treatments,” he said. Alzheimer’s is the most common form of dementia, a brain-wasting disease which in 2010 was estimated to be costing the world $604 billion a year. The fatal disease affects 44 million people worldwide, with the number set to triple by 2050, the campaign group Alzheimer’s Disease International says. Several big pharma firms including Roche, Eli Lilly, Merck & Co and Johnson & Johnson, are pursuing various approaches to get to the root cause of Alzheimer’s and try to find treatments to halt its progression. Yet over the past 15 years, more than 100 experimental Alzheimer’s drugs have failed in trial. Lovestone and other experts believe this may be because drug trials are conducted too late, in patients whose condition has already gone too far. A predictive test for use before people develop symptoms would help researchers select the right people for drug trials, and help show whether the experimental drugs are working. Previous studies have found that PET brain scans and tests of lumbar fluid can be used to predict the onset of dementia from people with a less severe condition known as mild cognitive impairment (MCI), but these tests are expensive and invasive, so scientists are keen to develop a cheaper, simpler blood test. MCI includes problems with day-to-day memory, language and attention. It can be an early sign of dementia, or a symptom of stress or anxiety. Around 10 percent of people diagnosed with MCI develop dementia within a year. Apart from regular assessments to measure memory decline, there is currently no accurate way of predicting who will or won’t develop dementia. For this study, published in the journal Alzheimer’s & Dementia, Lovestone’s team used blood samples from 1,148 people - 476 with Alzheimer’s, 220 with mild cognitive impairment and 452 elderly controls without dementia. They were analyzed for 26 proteins previously found to be linked with Alzheimer’s. The team found 16 of these 26 proteins to be strongly associated with brain shrinkage in either MCI or Alzheimer’s and then ran a second series of tests to see which of these could predict which patients would progress from MCI to Alzheimer’s. With this second series, they found a combination of 10 proteins capable of predicting with 87 percent accuracy whether people with MCI would develop Alzheimer’s disease within a year. Experts in the field welcomed the results but said they should be replicated in larger studies before an Alzheimer’s blood test could be rolled out for use in doctors’ clinics. “The results reported today are interesting, but as the authors point out there is still a very large amount of work remaining until a usable blood test for Alzheimer’s disease becomes available,” said Adrian Pini of the MRC Center for Developmental Neurobiology at King’s College London. James Pickett, head of research at the Alzheimer’s Society, said the research “does not mean that a blood test for dementia is just around the corner”. “These 10 proteins can predict conversion to dementia with less than 90 percent accuracy, meaning one in 10 people would get an incorrect result,” he said. “Accuracy would need to be improved before it could be a useful diagnostic test.” Claim: Study paves the way for a blood test to predict Alzheimer's.

SOLUTION: British scientists have identified a set of 10 proteins in the blood that can predict the onset of Alzheimer’s and call this an important step towards developing a test for the incurable brain-wasting disease.

PROBLEM: Paragraph: The National Park Service and the U.S. Public Health Service told the San Francisco Chronicle they launched an investigation after employees and visitors reported the problems this month. Federal officials said they haven’t identified the illness or the origin of the outbreak. Park officials said those who had gotten sick are getting better or already recovered. Federal officials were working with Aramark, the concessionaire that operates Yosemite’s restaurants, snack shops and hotels, to clean up and disinfect food service facilities in the park, including the famous Ahwahnee Hotel, Yosemite spokesman Scott Gediman said. “The park is reminding all employees and visitors to wash their hands frequently and stay home if they experience any symptoms of a gastrointestinal illness,” Gediman said in a statement. A message seeking comment from a spokesman for Aramark has not been returned. Aramark received numerous complaints from visitors about poor food quality, shuttle service and other services since it began managing Yosemite’s concessions four years ago. The Ahwahnee Hotel lost its prestigious four-diamond rating by AAA, a distinction the luxury hotel held since 1991, and is now listed as a three-diamond hotel. Visitors to the hotel at the foot of the iconic Half Dome have included Queen Elizabeth II and U.S. presidents. Claim: Stomach illness outbreak at Yosemite prompts major clean-up.

SOLUTION: Federal health officials are inspecting Yosemite National Park’s food service areas after at least a dozen people have fallen ill with stomach issues.

PROBLEM: Paragraph: In November 2018, the “Weird Facts” Facebook page posted a widely-shared meme which outlined the death of Joyce Carol Vincent, summarizing it as “In 2006, a woman (Joyce Carol Vincent) was found in her London flat, skeletonized, after 3 years of being dead — with the TV still running”:  Notwithstanding the somewhat crass imagery used in the meme, this was unfortunately a largely accurate description of the tragic circumstances surrounding the death of Joyce Carol Vincent, who did indeed remain undiscovered at home for around two years, dying around December 2003. According to material prepared for release to the news media by the Metropolitan Police, as well as reports by the BBC and the Press Association, the following are the known facts surrounding Vincent’s demise. Some readers might find the details disturbing. On 26 January 2006, Vincent’s remains were discovered at her apartment in Wood Green, north-east London. Workers from the Metropolitan Housing Trust, an organization which provides affordable housing and is now known as Metropolitan Thames Valley, had forced entry while attempting to inquire about thousands of pounds of unpaid rent arrears. Vincent had been placed in the small apartment as part of a scheme for victims of domestic violence. Vincent’s remains were badly decomposed, and pathologist Dr. Simon Poole later described them as being “largely skeletal,” which supports the claim made in the “Weird Facts” meme. According to evidence heard at a coroner’s inquest, Vincent was found lying on her back on the floor of her living room next to a shopping bag and Christmas presents which she had wrapped but never delivered. Her television was indeed still switched on when Vincent was found. She was identified by reference to dental records. Based on the expiration dates of food and medication found in Vincent’s flat, it was estimated that she had died around December 2003, some two years earlier — not three years earlier, as the “Weird Facts” meme and several news reports mistakenly stated. She was born in London to Grenadian immigrant parents in 1965, and was 38 years old at the time of her death. In the years after Vincent was discovered, the filmmaker Carol Morley tracked down her friends, colleagues and associates. In interviews which would ultimately form the basis of the 2011 documentary film Dreams of a Life, those who knew Vincent universally recalled their shock and disbelief at the circumstances of her death and discovery. In the film some friends recounted actually having read news accounts of her death in April 2006, but without an accompanying photograph, they did not connect the horrific circumstances of her discovery with the person they had known. According to those accounts, Vincent had for many years been a very social, popular professional young woman who worked in London’s fast-paced financial district in the 1980s and 1990s, was highly intelligent and charming, and was remarkably attractive and frequently the object of male attention. Vincent, who was at one time an aspiring singer, was acquainted with the soul vocalist Betty Wright, and had dinner with other iconic musical artists, including Gil Scott-Heron, Jimmy Cliff, and Ben E. King. In 1990, Vincent briefly met and conversed with Nelson Mandela backstage at a concert in London’s Wembley Stadium. Although she had many friends, Vincent’s friendships appear to have been somewhat fleeting, and despite the deep affection in which she was held, she was known for “drifting” in and out of social groups and relationships and sometimes appeared troubled. Her acquaintances recalled that she was distant towards her family members. According to Morley’s interviews with friends of Vincent, she became engaged to marry an unidentified man in the late 1990s, and the Metropolitan Police later noted that she had been involved in a “domestic incident” in 1998. In Morley’s documentary, Vincent’s friends observed that she was likely to have been in at least one abusive relationship during that time. By 2001, Vincent left her job at the accounting firm Ernst & Young and progressively lost contact with her family members, friends and former colleagues, working for a time as a cleaner. She changed addresses frequently but moved into her final apartment in Wood Green in February 2003, having been placed there as part of a women’s refuge program for victims of domestic violence. Her friends have speculated that she may have become isolated and withdrawn over time because she was ashamed of the abuse she had suffered and the shift in her professional and personal circumstances, and she may also have been avoiding detection by an abusive former partner. In November 2003, she was briefly hospitalized after vomiting blood and was diagnosed with a peptic ulcer. Although she is believed to have died around a month later, the coroner was unable to arrive at a cause of death due to the decomposition of her remains by January 2006. She also suffered from asthma, which was cited by her friends as a possible cause of death. Claim: In 2006, the skeletal remains of Joyce Carol Vincent were found in her home, with the television on, years after her death. 

SOLUTION:
Vincent did not take drugs or smoke and did not drink alcohol to excess. From the outset, the Metropolitan Police made it clear that they did not suspect foul play in her demise.