Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Input: Consider Input: Context: Mahjong, that favorite pastime of "old folks" in Shanghai, is finding a new audience among younger players, and many university students are becoming mad about this traditional Chinese game. Students at Fudan University have even formed a Mahjong club. This resurgence of the game, however, is not without its critics. Some people still associate the game with gambling and for many years Mahjong was banned in China. One critic, surnamed Meng, was quoted as saying, "Mahjong is a bad custom that will distract students from studies." But Yu Guangyuan, former vice-president of the Chinese Academy of Social Sciences , says Mahjong is a "healthy, scientific, friendly mind game." Mr. Yu's opinion seems to be shared by the majority of Chinese. They see the game as an activity that requires great concentration and intellectual skill. They also see the game as an important part of Chinese culture and a pastime that brings family and friends closer together. This Spring Festival many families will no doubt spend hours around the Mahjong table getting reacquainted with each other. For them, playing Mahjong is a way of spending quality family time. No one knows who invented Mahjong. Some say it was Confucius, others say the current form of the game was developed right here in Shanghai in the late19th century. It is certainly because of Shanghai that the game enjoys its worldwide popularity. It was brought to America in the 1920s and has since spread throughout Europe and other parts of Asia. There is now a World Championship of Mahjong which is held every year. This year's championship was held in Chongqing and attracted players from America, Europe and Russia, as well as students from Peking University, Tshinghua University and Nankai University. There was no prize money, but the players delighted in using their wits and their understanding of statistics and probability theory to defeat their clever opponents. Of course, Mahjong doesn't have to always be that intense. For young people it can be a way to relax and to socialize, a chance to get away from their computers and talk to other people face to face. So, this Spring Festival, why not get out the "old folks" tiles: it's good to be mad about Mahjong! 
 Question: What is the best title of the passage?

Output: mad about mahjong


Input: Consider Input: Context: Highly conserved sequences at the 5' splice site and branch site of U12-dependent introns are important determinants for splicing by U12-dependent spliceosomes. This study investigates the in vivo splicing phenotypes of mutations in the branch site consensus sequence of the U12-dependent intron F from a human NOL1 (P120) minigene. Intron F contains a fully consensus branch site sequence (UUCCUUAAC). Mutations at each position were analyzed for their effects on U12-dependent splicing in vivo. Mutations at most positions resulted in a significant reduction of correct U12-dependent splicing. Defects observed included increased unspliced RNA levels, the activation of cryptic U2-dependent 5' and 3' splice sites, and the activation of cryptic U12-dependent branch/3' splice sites. A strong correlation was observed between the predicted thermodynamic stability of the branch site: U12 snRNA interaction and correct U12-dependent splicing. The lack of a polypyrimidine tract between the branch site and 3' splice site of U12-dependent introns and the observed reliance on base-pairing interactions for correct U12-dependent splicing emphasize the importance of RNA/RNA interactions during U12-dependent intron recognition and proper splice site selection. 
 Question: Which is the branch site consensus sequence in U12-dependent introns?

Output: uuccuuaac


Input: Consider Input: Context: The acromelic dysplasia group includes three rare disorders: Weill-Marchesani syndrome (WMS), Geleophysic dysplasia (GD) and Acromicric dysplasia (AD) all characterized by short stature, short hands and stiff joints. The clinical overlap between the three disorders is striking. Indeed, in addition to the diagnostic criteria, they all share common features including delayed bone age, cone shaped epiphyses, thick skin and heart disease. In contrast, a microspherophakic lens seems to be a characteristic feature of WMS whereas hepatomegaly and a severe outcome are encountered only in the most severe forms of GD. Finally, WMS is transmitted either by an autosomal dominant or an autosomal recessive (AR) mode of inheritance, GD by an autosomal recessive mode of inheritance and AD by an autosomal dominant mode of inheritance. Using genetic approaches, we have identified the molecular basis of WMS and GD which both involved the same superfamily of proteins, the ADAMTS [A Disintegrin-like And Metalloproteinase domain (reprolysin type) with ThromboSpondin type 1 repeats (TSR)]. We have found ADAMTS10 mutations in the recessive form of WMS and Fibrillin 1 mutations in the dominant form of WMS. More recently, we have identified ADAMTSL2 mutations in GD. The function of ADAMTS1 0 and AD AMTSL 2 are unknown. But the findings of FBN1 and ADAMTS10 mutations in WMS suggest a direct link between the two proteins. Using a yeast double hybrid screen, we have identified LTBP1 (Latent TGFbeta Binding protein 1) as a partner of ADAMTSL2. The combination of these findings suggests that ADAMTS10 and ADAMTSL2 are both involved in the microfibrillar network. 
 Question: What is the mode of inheritance of Acromicric dysplasia?


Output: autosomal dominant