In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

[EX Q]: Question: Acetylation of histones affects transcription: 
 Options:  <1> Blocking the incorporation of other components of the transcription machinery. <2> Preventing the remodeling of chromatin. <3> Facilitating the action of helicases. <4> Decreasing sensitivity to nuclear receptors. <5> Reducing the affinity of histones for DNA.
[EX A]: 5

[EX Q]: Question: What procedure is part of the cognitive-behavioral intervention program for hypochondria proposed by Warwick and Salkovskis ?: 
 Options:  <1> The systematic desensitization in imagination to extinguish the fear of interoceptive sensations. <2> The stopping of thought to block intrusive thoughts about the disease. <3> The training in mindfulness to reduce the appearance of annoying bodily sensations. <4> The prevention of response to reduce body checking behaviors and search for reassuring information. <5> The resolution of the underlying conflicts related to guilt and dependency needs.
[EX A]: 4

[EX Q]: Question: Raile and Marriner in their studies on the theoretical works in nursing, review different aspects among which are those referred to semantics and structure. This analysis of the concrete theoretical framework refers to: 
 Options:  <1> The simplicity <2> The generality <3> The empirical precision. <4> The deductible consequences. <5> The clarity.
[EX A]:
5