Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Ex Input:
Context: Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, demonstrated efficacy and safety in moderate-to-severe plaque psoriasis when administered via subcutaneous injection. Self-administration by pre-filled syringe (PFS) can offer patients clinical benefits of a drug, with increased convenience. To assess efficacy, safety and usability of secukinumab administration via PFS in subjects with moderate-to-severe plaque psoriasis. Subjects in this phase 3 trial were randomized 1:1:1 to secukinumab 300 or 150mg or matching placebo. Results to week 12 are presented here. Each treatment was delivered using a PFS once weekly to week 4, and again at week 8. Co-primary endpoints were secukinumab superiority over placebo for week 12 PASI 75 (75% reduction in Psoriasis Area and Severity Index) and IGA mod 2011 (2011 modified Investigator's Global Assessment) 0/1 response rates. Secondary endpoints included PFS usability, determined by observer rating of successful, hazard-free self-injection and subject rating of acceptability by the Self-Injection Assessment Questionnaire (SIAQ). Co-primary endpoints were met, with demonstration of superiority for each secukinumab dose vs. placebo at week 12 (PASI 75: 759%, 695% and 0% for secukinumab 300mg, 150mg and placebo; IGA mod 2011 0/1: 690%, 525% and 0%, respectively; P<00001 for all comparisons vs. placebo). PFS usability was high: 100% of subjects successfully self-administered treatment at week 1, and subjects reported high SIAQ-assessed acceptability of the PFS throughout the trial. No new/unexpected safety signals were observed. Secukinumab administration by PFS was effective, with an acceptable safety profile and high usability. The PFS provides a reliable, convenient form of secukinumab administration in subjects with moderate-to-severe plaque psoriasis. 
 Question: Which molecule is targeted by a monoclonal antibody Secukinumab?

Ex Output:
interleukin-17a


Ex Input:
Context: The Texans' ninth match was an AFC South rivalry match against the Jaguars at EverBank Field. In the first quarter the Texans trailed early as kicker Josh Scobee hit a 38-yard field goal. They replied after kicker Neil Rackers made a 24-yard field goal. They trailed again in the 2nd quarter with RB Maurice Jones-Drew getting a 3 and a 9-yard TD run. However, the lead didn't last long after RB Arian Foster got a 1-yard TD run, and QB Matt Schaub threw a 9-yard TD pass to WR Andre Johnson. The Jaguars stayed in the lead when QB David Garrard completed a 52-yard TD pass to TE Zach Miller, but the Texans replied again with Schaub finding WR Kevin Walter on an 18-yard TD pass. Suddenly, the Texans' defense broke through with only a few seconds remaining after Garrard made a 50-yard TD pass to WR Mike Thomas. The ball was batted into his hands by Texans Defensive back Glover Quin, who made an attempt to bat the ball to the ground. 
 Question: In what quarter did both teams score a field goal?

Ex Output:
first quarter


Ex Input:
Context: The film is split into three acts, and narrated by one of the protagonists Kari Kamiya who has a role in the first and third act of the film. Kari gives a brief introduction to the world of Digimon, explaining the existence of Digimon, monsters that were created from computer data, and live in another dimension called the Digital World. She continues, explaining she is part of a team called the Digidestined, who are partnered with Digimon to protect the world from evil. There were only a small handful of members at first, but it is added a few members introducing a new character for the film, named Willis, who lives in Colorado. Willis has two twin Digimon named Gummymon and Kokomon, but had no other friends to rely on. This takes us into the first act, on the night in 1995 when Kari and her big brother Tai encountered their first Digimon. Kari also reveals that Willis met his Digimon on the same night.In Highton View Terrace, Tokyo, Japan, Tai awakens in the night and finds Kari observing their fathers computer, where a large Digiegg emerges. The next day, Tai and Kari witness the egg hatch into Botamon, who quickly bonds with Kari. Tai goes to answer the telephone but the call is interrupted. Returning to the bedroom, Tai discovers Botamon has transformed into Koromon, a pink ball-like Digimon resembling a space hopper. This is a process Kari later explains as digivolving, which allows a Digimon to turn into a stronger form, which affects electrical equipment. Kari steals food from the family cat Miko, causing her to attack and scratch both Tai and Koromon. At sunset, Tai and Kari discover Koromon can speak, and he calls them his best friends.That night, another electrical surge causes Koromon to digivolve into Agumon, an enormous but simple-minded dinosaur, who leaps out the window with Kari on his back. Tai pursues them into the night as Agumon wanders the street, scaring Kari when he starts blowing things up with fireballs. A second, enormous Digiegg appears in the sky, hatching to unleash Parrotmon, a large bird-like Digimon able to fire electrical blasts. As Tai reaches Kari, Parrotmon destroys an overpass, burying Agumon under rubble. However, Agumon digivolves into Greymon and battles Parrotmon. Parrotmon knocks Greymon out, but Tai uses Karis whistle to awaken him. Greymon leaps up and obliterates Parrotmon with a fire blast, but the attack destroys him in the process.In narration, Kari explains that she, Tai, and six other children were amongst those who witnessed the battle and were chosen to become the Digidestined. Karis narration about the team acts as a segway into the second act, set in 2000, a year after the events of the television series Digimon Adventure.Koushiro Izzy Izumi, a computer whiz and member of Digidestined, spots a computer virus has somehow appeared on the internet and is attacking something. Getting an image of its target, Izzy amongst thousands of others across the world, witness the virus mutate a Digiegg, causing it to hatch and become a Digimon, which addresses the world with Hello!. Across town, Tai tries to compose an apology letter to his friend Sora Takenouchi after they had a falling out, but he has difficulty deciding whether or not to end the e-mail with love or from. Kari appears, off to a birthday party, sending the e-mail to Sora behind Tais back, but Tai discovers the e-mail was not delivered.A montage follows, showing what the eight Digidestined are up to Sora wanders the streets and checks her hair in a shop window but fails to notice the virus Digimon on a large screen, Joe Kido, the oldest of the group and voice of reason misses a train to an exam for summer school, Matt Ishida and his little brother T.K. are visiting their grandmother in the countryside, Kari attends a friends birthday, and Izzy races for Tais apartment. The eighth member Mimi is absent from home. Tai bemoans to his mother that Kari gets to eat cake and their fridge is empty, so Tais eccentric mother suggests she attempt to make a cake. Izzy appears, informing Tai of 
 Question: What emerges from Tai and Kari Kamiya's computer?

Ex Output:

botumon