Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.

Input: Consider Input: The test examines more than 2 million spots in a person’s genetic code, seeking variants that individually nudge a person’s obesity risk up by a tiny amount. The researchers drew on previously published data about those variants to create a risk score. A high score didn’t guarantee obesity, nor a low score rule it out. But middle-aged people with scores in the top 10 percent were 25 times as likely to be severely obese as those in the bottom 10 percent, scientists reported in a paper released Thursday by the journal Cell. Those two groups were separated by an average weight difference of about 29 pounds (13 kilograms), researchers said. Analysis showed the genetic propensity to obesity began having an effect on weight around age 3. Up to about age 8, “you might be able to make a difference in the kids who are born susceptible to obesity,” said one author of the study, Dr. Sekar Kathiresan of Massachusetts General Hospital in Boston and the Broad Institute of MIT and Harvard. But it will take further research to see whether intervening would work, Kathiresan said. The results for middle age came from a study of about 288,000 people. Overall, the risk-score research included data from more than 300,000 people at various ages. Severe obesity was defined as a body mass index of 40 or more. Results show genetic inheritance “plays a large role in how heavy one gets,” Kathiresan said. The risk score probably takes about half of a person’s genetic propensity into account, he said, and it shows similar accuracy in predicting ordinary obesity, defined as a BMI of 30 or more. Even if one inherits a propensity for obesity, he said, “you still have control over your fate. You’re not fated to be obese, but it’s very clear those individuals who’ve inherited susceptibility have to work that much harder to keep the weight off.” Among study participants with the highest scores, he noted, 17 percent were of normal weight. Other analyses show that people who remain lean despite an inherited propensity for obesity tend to eat better and have more physical activity than others with a high score who got fat. “So you can do something about it,” he said. Ruth Loos, a professor of environmental medicine and public health who did not participate in the study, said the risk score explains more of people’s genetic tendency than previous studies did. But she doubted it would be useful in a doctor’s office. It is “never going to be a good predictor,” said Loos, of the Icahn School of Medicine at Mt. Sinai in New York. She noted that in one test of the score’s predictive power, only 58 of the 371 subjects scoring in the top 10 percent ended up severely obese. And many other severely obese people didn’t score in the top 10 percent, she said. Simply asking about family history of obesity would probably work better, she said. The large role of lifestyle in obesity means a purely gene-based predictor will never be perfect, she said. Kathiresan, a cardiologist, said the risk score is best seen as a risk indicator, like high cholesterol. Most people with high cholesterol don’t get heart attacks, he said, but they do run a higher risk than others. Jason Boardman of the University of Colorado Boulder said genetic variants might affect body size indirectly, through an impact on lifestyles or other social and behavioral traits. Other research suggests the effect of genes on size depends on what kind of social and physical environment a person lives in, including such factors as access to unhealthy foods, he said in an email. ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.

Output: Study: Genetic test predicts middle-aged obesity risk.


Input: Consider Input: The committee is also seeking the indictment of Vale and dam stability auditor TÜV SÜD for environmental damages and corporate responsibility for actions of their employees in the late-January disaster that killed nearly 250 people. The 400-page report recommended that a total of 15 individuals, including the two executives, be indicted for murder, wrongful bodily injury, environmental damages and pollution. Fabio Schvartsman stepped down as Vale’s CEO under pressure from prosecutors in March. Luciano Siani, also targeted by the committee, continues to serve as CFO. The committee’s initial report recommended manslaughter charges but at a hearing it approved an amendment to upgrade the charges to murder and add a 15th individual to its list for recommended indictments. Vale, a formerly state-owned Brazilian “national champion” which is a leading exporter and employer, said it “respectfully disagrees” with the indictment recommendations. A “forensic, technical and scientific conclusion about the causes of the dam burst” should be arrived at before holding certain people responsible, the company asserted in a statement. TÜV SÜD said it was cooperating in full but declined to comment further, citing ongoing investigations. Vale shares, which early in the session touched their highest since before the Brumadinho disaster, closed down 4.2%. The nonbinding recommendations could influence prosecutors in their ongoing probe of Vale and its executives for negligence regarding the disaster. “Vale’s tragedy is a series of tragedies,” the committee said in its report. “The immeasurable human loss; the countless dead animals; the environment destroyed for years, perhaps decades; the dreams and heritage of a lifetime buried by the carelessness, neglect, greed, usury, irresponsibility, indifference and sloppiness of a company that used to be a role model.”  Brazil must take action to ensure that “never again” will such a disaster occur, it said, recommending three laws that would require congressional approval. One would outlaw all tailings dams for mining and industrial waste. That would go far beyond a ban instituted in February on the specific type of “upstream” dam that ruptured. It would allow for 10 years to decommission the hundreds of existing tailings dams around the country, a costly move for miners. A separate bill would hike taxes calculated on mineral production, with a tax of up to 40% on more profitable or larger scale mines. The investment banking unit of Brazil’s Bradesco said such a tax is unlikely to be implemented given that comparable taxes in Australia and Mexico are up to 7.5%. But the bank said the rate is likely to rise for Brazilian miners from the current 3.5%. A third proposed law would expand the list of environmental crimes. Barclays analyst Amos Fletcher said he doubted that Congress would follow through on shutting down all types of tailings dams, a move that would halt a significant amount of mineral production, which Brazil counts on for a large portion of its GDP, he said. The recommendations may be depressing Vale’s stock price more than the indictments because of worries that such changes “would lead to more supply being squeezed,” he said. Vale’s tailings dam ruptured in the city of Brumadinho in the mining state of Minas Gerais in late January, releasing a torrent of mud that buried hundreds of people, including a cafeteria full of workers at lunchtime. In the following months, investigators and regulators pointed toward a risky “upstream” style of dam construction, improper maintenance and negligence. TÜV SÜD certified the dam as stable in 2018 despite pointing out concerns about drainage and monitoring systems. Vale has argued that it followed all the required safety measures. While authorities have yet to conclude the cause of the rupture, a Minas Gerais state official and other experts suspect liquefaction, in which solid materials such as sand lose strength and become more like liquid. That was the same cause of a 2015 rupture of another upstream Vale dam that killed 19.

Output: Brazil Senate panel says Vale CFO, ex-CEO should be indicted for murder.


Input: Consider Input: Scientists dubbed the startling findings “immune amnesia.” The body can rebuild those defenses — but it could take years. And with measles on the rise, “it should be a scary phenomenon,” said Dr. Michael Mina of Harvard’s school of public health, lead author of research published Thursday in the journal Science. “This goes under the radar” because doctors wouldn’t necessarily connect a child’s pneumonia to measles they suffered a year earlier, Mina explained. “But would they have gotten it if they hadn’t gotten measles?” The Harvard team analyzed blood samples taken from 77 children before and after a measles outbreak in an unvaccinated community in the Netherlands. They looked for antibodies, which remember viruses and bacteria they encounter to guard against a repeat infection. After recovering from measles, the youngsters were left with plenty of antibodies against that virus — but ones they’d previously harbored against other germs had plummeted. In the most severe cases, “they’re just as vulnerable as if they were infants,” said study senior author Stephen Elledge, a Harvard geneticist. Elledge is paid by the Howard Hughes Medical Institute, which also supports AP’s Health & Science Department. A separate study, published Thursday in Science Immunology, supported the findings. Researchers from Britain’s Wellcome Sanger Institute used the Dutch blood samples to genetically test antibody-producing cells, and concluded measles is eliminating enough to re-set the immune system to a baby-like state. If protection against the misery — and sometimes life-threatening effects — of measles isn’t enough reason to vaccinate children, specialists said the two studies offer a powerful new rationale. “There really are profound gaps and holes” in someone’s immunity after measles, said Dr. Anthony Fauci of the U.S. National Institutes of Health, which helped fund the Harvard work. “You ultimately recover but after a year or two or sometimes more.” “It’s doubly important to vaccinate children,” agreed Dr. Mark Mulligan of NYU Langone Health, who wasn’t involved with the new research. “It’s a vaccine that protects against the specific target, measles virus, but also against immune suppression.” Measles is one of the world’s most contagious viruses, able to spread through coughs and sneezes for four days before someone develops the characteristic rash. It sometimes leaves children with brain damage or hearing loss, and while deaths are rare in the U.S., measles killed 110,000 people globally in 2017. The vaccine offers powerful protection but a lack of access means measles remains rampant in many lower-income countries. Even the U.S., where most children are immunized, has seen a resurgence fueled by outbreaks in unvaccinated communities that in turn threaten people too young or sick to be immunized. So far this year, the Centers for Disease Control and Prevention has counted more than 1,200 U.S. measles cases, the most since 1992. Doctors have long known that people temporarily experience weakened immunity after measles. Using decades of health records, Mina previously reported that child deaths from other infections jumped after a measles outbreak, increases that lasted two or three years. But no one knew why, until the new study. The Dutch children started out pretty healthy: Technology developed in Elledge’s lab found antibodies in their blood against typical childhood germs. But two months after recovering from measles, the children had lost on average 20 percent of their usual antibody mix. Some lost up to 70 percent of protection against specific bugs, limiting their ability to respond if they encounter that germ again. Importantly, researchers didn’t find loss of antibodies in “control” populations that didn’t get infected with measles — or in children after they received the measles vaccine. ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.


Output: Measles saps kids’ ability to fight other germs.