TASK DEFINITION: Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
PROBLEM: Context: Ion Assault is a multidirectional shooter video game developed by Coreplay and published by Black Inc. for the Xbox Live Arcade, PlayStation Network, and Microsoft Windows. 
 Question: Who worked on Ion Assault?

SOLUTION: coreplay

PROBLEM: Context: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. Despite significant progresses in the last decades, the origin of this cancer remains unclear and no efficient therapy exists. PDAC does not arise de novo: three remarkable different types of pancreatic lesions can evolve towards pancreatic cancer. These precursor lesions include: Pancreatic intraepithelial neoplasia (PanIN) that are microscopic lesions of the pancreas, Intraductal Papillary Mucinous Neoplasms (IPMN) and Mucinous Cystic Neoplasms (MCN) that are both macroscopic lesions. However, the cellular origin of these lesions is still a matter of debate. Classically, neoplasm initiation or progression is driven by several genetic and epigenetic alterations. The aim of this review is to assemble the current information on genetic mutations and epigenetic disorders that affect genes during pancreatic carcinogenesis. We will further discuss the interest of the genetic and epigenetic alterations for the diagnosis and prognosis of PDAC. Large genetic alterations (chromosomal deletion/amplification) and single point mutations are well described for carcinogenesis inducers. Mutations classically occur within key regions of the genome. Consequences are various and include activation of mitogenic pathways or silencing of apoptotic processes. Alterations of K-RAS, P16 and DPC4 genes are frequently observed in PDAC samples and have been described to arise gradually during carcinogenesis. DNA methylation is an epigenetic process involved in imprinting and X chromosome inactivation. Alteration of DNA methylation patterns leads to deregulation of gene expression, in the absence of mutation. Both genetic and epigenetic events influence genes and non-coding RNA expression, with dramatic effects on proliferation, survival and invasion. Besides improvement in our fundamental understanding of PDAC development, highlighting the molecular alterations that occur in pancreatic carcinogenesis could provide new clinical tools for early diagnosis of PDAC and the molecular basis for the development of new effective therapies. 
 Question: Which is the molecular mechanism underlying K-ras alterations in carcinomas?

SOLUTION: point mutations

PROBLEM: Context: Many French academics,teachers and parents complain because they feel that intellectual levels are falling rapidly!The figures prove it:young people visit museums less,spend their lives chatting on the Internet,read nothing but Stephen King,while watching American soaps such as Friends or reality shows like Star Academy on television,music player glued to their cars,and the games console handy. It is,however,easy to see these habits in a positive light.Music is the favorite leisure activity:86% of 14-to18-year-olds put it at the top of their activities,above the cinema(71%),clubbing(68%),sport(56%) and television(48%).For 90% of young people aged 14to 18,radio is also very popular:they listen to it every day without exception.International popular music has a strong showing,but songs in French are still in the majority(60%). Young people do,of course,watch a lot of television,but less than their elders,and if they tend to choose mostly soaps and reality TV shows,that is because these are the programs people talk about,which encourages social interaction.Do young people read less than they used to?Maybe,but that's also true of the elders.Young people still read more than their elders.When asked,"Do you like reading?",94% of 14-to-18-year-olds say they do,and 81% are convinced that computers will never replace books. Contrary to popular belief,reading continues to occupy an extremely important place in leisure-time activities,but the reading matter young people choose has changed considerably:there is a greater variety of media(computers and new technologies) and young people admit to taste they would perhaps have been ashamed of in the past.For example,comic strips,Stenphen King or other authors not recognized by mainstream culture,such as Betty Mahmoody (Not Without My Daughter),Mary Higgins Clark or Jostein Gaader (Sophie's World).As Beatrice Toulon,Editor in Chief of the magazine Phosphore,see it,"They don't read the same things as their parents did,but they are not afraid to admit it.They have their own culture,which they flaunt openly!" 
 Question: Which activity is the most popular with young French people?

SOLUTION:
music.