In this task, you are given a passage which has a question and the context. You have to generate an answer to the question based on the information present in the context.

[EX Q]: Context: Galbeta1-4GlcNAcalpha2-6 sialyltransferase (ST6GalI) is an acute phase reactant whose release from cells can be induced by proinflammatory cytokines. Because patients with chronic renal failure have high circulating levels of proinflammatory cytokines, we hypothesized that patients on the renal transplant waiting list would have high circulating levels of ST6GalI, which might adversely affect post-transplant events.', 'Levels of ST6GalI were measured in the serum of 70 patients immediately before renal transplant; these were correlated with posttransplant events, such as delayed graft function and rejection.', 'The mean serum level of ST6GalI was significantly higher in the patients (3162+/-97 U) than in 19 controls (2569 +/- 125 U; P<0.003). Patients who required dialysis posttransplant for treatment of delayed graft function (n=20) had significantly higher levels of ST6GalI pretransplant (3735+/-228 U) than patients (n=50) who did not require dialysis (2933+/-83 U; P<0.0001). In a multivariate analysis the ST6GalI level and cold ischemic time were found to be independent risk factors for the development of delayed graft function.\Question: Do increased levels of GALbeta1-4GLCNACalpha2-6 sialyltransferase pretransplant predict delayed graft function in kidney transplant recipients?
[EX A]: ST6GalI levels are high in renal failure patients awaiting a renal transplant and may be a risk factor for the development of delayed graft function. The assessment and perhaps modulation of a potential transplant recipient's ST6GalI systemic level may be beneficial.

[EX Q]: Context: Mast cells play a central role in allergic and inflammatory diseases. Several reports indicated role of peroxisome proliferator-activated receptor gamma (PPARgamma) on mast cell function. However, there is no report about the role of PPARgamma on differentiation of mast cells from the progenitors. In this study, we investigated the role of PPARgamma in regulating bone marrow-derived mast cell maturation and the therapeutic implications for mast cell-related diseases such as atopic or contact dermatitis.', 'We used in vitro cell culture system for mast cell differentiation from bone marrow-progenitors using specific ligands and lentiviral-mediated short hairpin RNA of PPARgamma, and in vivo murine dermatitis models.', 'Activation of PPARgamma inhibited the maturation of bone marrow progenitors into connective tissue-type mast cells (CTMCs) through up-regulation of GATA-4 and GATA-6 resulting in a decrease in expression of histidine decarboxylase and mast cell histamine content. In comparison, the differentiation of bone marrow progenitors into CTMCs was significantly accelerated by the knockdown of PPARgamma expression by lentiviral-mediated short hairpin RNA. Peroxisome proliferator-activated receptor gamma ligand administration to mice inhibited the maturation of mast cells resulting in attenuation of atopic and contact dermatitis via diminishment of the number of mature mast cells.\Question: Does activation of peroxisome proliferator-activated receptor gamma suppress mast cell maturation involved in allergic diseases?
[EX A]: Our results indicate that PPARgamma is one of master regulators on mast cell maturation and potentially useful for the therapy in various disorders involving mast cell activation.

[EX Q]: Context: To investigate the feasibility of human dermal fibroblasts in vitro differentiation into chondrogenic phenotype with induction of cartilage-derived morphogenetic protein (CDMP) growth factor.', 'Human dermal fibroblasts were isolated from foreskin and cultured in monolayer ex vivo. Dermal fibroblasts of passage2 was plated at density of 1 x 10(4) cells/cm(2) and induced with CDMP1 (100 ng/ml) in medium of F12 + 10% FBS. After 7 days of induction, morphology of cells was observed under phase-contrast microscopy and the length:width ratio of cells was calculated by Image Plus software analysis. Expression of type I, II, III collagen was detected by immunofluorescence and observed with confocal microscopy. The method of Western-Blot was applied to detect secretion of collagen type II. mRNA expression of chondrogenic related Sox9, Aggrecan as well as collagen type II, IX was detected by RT-PCR. The osteogenic related expression of collagen type X, Alkaline Phosphatase (AKP) was also detected by RT-PCR. Pellet cultured dermal fibroblasts at a density of 2 x 10(7) cells/ml was observed respectively for proteoglycan and collagen type II expression with Alcian blue and immunohistochemistry staining.', 'With the induction of CDMP1, the morphology of cells changed from spindle fibroblastic appearance to that of typical chondrocyte-like polygon shape. By Image Plus software analysis, it was found that the length/width ratio changed significantly from 7.40 +/- 1.30 of preinduction to 1.40 +/- 0.15 of post-induction (P < 0.05). No significant difference was found between the postinduction and normal chondrocyte (1.29 +/- 0.24). By confocal microscope observation, expression of collagen type II was found intracellularly in CDMP1 treated fibroblasts. Western-Blot detection confirmed collagen type II expression by 7 days induction. RT-PCR gene expression analysis of characteristic chondrogenic related genes, such as Sox9, Aggrecan as well as collagen type II, IX, revealed induction of chondrocytic phenotype in monolayered culture upon stimulation with CDMP1 for 7 days. While osteogenic related gene expression of collagen type X, AKP was not detected by RT-PCR, which indicates that osteogenic differentiation was not initiated by CDMP1 in 7 days culture. Histological staining of proteoglycan with Alcian blue and immunohistochemical staining cartilage specific type II collagen revealed deposition of typical cartilage extracellular matrix deposition in pellet cultured fibroblasts.\Question: Does [ Cartilage-derived morphogenetic protein 1 initiate chondrogenic differentiation of human dermal fibroblasts in vitro ]?
[EX A]:
These results suggests human dermal derived fibroblast could be differentiated into chondrogenic phenotype with CDMP1 induction in vitro.