instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: When is a person considered an adult? That depends. Most teens become physically mature by the age of 16 or so. But they are not adults in a legal sense until they are older. For example, in the U.S., you must be 18 to vote. Once adulthood begins, it can be divided into three stages: (1) early, (2) middle, and (3) late adulthood. Early adulthood starts at age 18 or 21. It continues until the mid-30s. During early adulthood, people are at their physical peak. They are also usually in good health. The ability to have children is greatest during early adulthood, as well. This is the stage of life when most people complete their education. They are likely to begin a career or take a full-time job. Many people also marry and start a family during early adulthood. Middle adulthood begins in the mid-30s. It continues until the mid-60s. During middle adulthood, people start to show signs of aging. Their hair slowly turns gray. Their skin develops wrinkles. The risk of health problems also increases during middle adulthood. For example, heart disease, cancer, and diabetes become more common during this time. This is the stage of life when people are most likely to achieve career goals. Their children also grow up and may leave home during this stage. Late adulthood begins in the mid-60s. It continues until death. This is the stage of life when most people retire from work. They are also likely to reflect on their life. They may focus on their grandchildren. During late adulthood, people are not as physically able. For example, they usually have less muscle and slower reflexes. Their immune system also doesnt work as well as it used to. As a result, they have a harder time fighting diseases like the flu. The risk of developing diseases such as heart disease and cancer continues to rise. Arthritis is also common. In arthritis, joints wear out and become stiff and painful. As many as one in four late adults may develop Alzheimers disease. In this disease, brain changes cause mental abilities to decrease. This family picture shows females in each of the three stages of life. Which stage does each represent? Despite problems such as these, many people remain healthy and active into their 80s or even 90s. Do you want to be one of them? Then adopt a healthy lifestyle now and follow it for life. Doing so will increase your chances of staying healthy and active to an old age. Exercising the body and brain help prevent the physical and mental effects of aging. 
 Question: during this time, brain changes cause mental abilities to decrease.
answer:
late adulthood


question:
Context: NADPH oxidase (Nox) family enzymes are one of the main sources of cellular reactive oxygen species (ROS), which have been shown to function as second messenger molecules. To date, seven members of this family have been reported, including Nox1-5 and Duox1 and -2. With the exception of Nox2, the regulation of the Nox enzymes is still poorly understood. Nox1 is highly expressed in the colon, and it requires two cytosolic regulators, NoxO1 and NoxA1, as well as the binding of Rac1 GTPase, for its activity. In this study, we investigate the role of the tyrosine kinase c-Src in the regulation of ROS formation by Nox1. We show that c-Src induces Nox1-mediated ROS generation in the HT29 human colon carcinoma cell line through a Rac-dependent mechanism. Treatment of HT29 cells with the Src inhibitor PP2, expression of a kinase-inactive form of c-Src, and c-Src depletion by small interfering RNA (siRNA) reduce both ROS generation and the levels of active Rac1. This is associated with decreased Src-mediated phosphorylation and activation of the Rac1-guanine nucleotide exchange factor Vav2. Consistent with this, Vav2 siRNA that specifically reduces endogenous Vav2 protein is able to dramatically decrease Nox1-dependent ROS generation and abolish c-Src-induced Nox1 activity. Together, these results establish c-Src as an important regulator of Nox1 activity, and they may provide insight into the mechanisms of tumor formation in colon cancers. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
answer:
nadph oxidase 1


question:
Context: Ten-year-old Chihiro (voice: Daveigh Chase in the 2002 English dub) and her parents (voices: Lauren Holly and Michael Chiklis) drive to their new home. Chihiro is whiny and unhappy about the move, especially when she notices that the bouquet her friend gave her as a good-bye gift is wilting. In sight of their new house, they take a wrong turn and follow a bumpy, decayed old road through the woods; Chihiro sees an odd old statue through the trees as they drive by. The road ends at a tunnel leading to an abandoned theme park. It gives Chihiro the creeps, but her parents persuade her to go in with them and look around.After wandering across a grassy landscape and a dry riverbed, they climb a stone staircase and come to a street lined with restaurants and shops. Most are deserted, but the aroma of cooking leads them to the one restaurant that's well stocked with food -- though it's mysteriously deserted. Mom and Dad are hungry and start eating, despite Chihiro's objections. The food is delicious, and Chihiro wanders away to explore while they eat. She finds a towering, ornate building that she recognizes as a bathhouse (a spa resort); there's a train track running under it. She meets a boy (voice: Jason Marsden) in traditional dress who is alarmed to see her; he tells her to leave and get back across the river before it gets dark. Chihiro runs back to her parents, but they're still eating -- and they've turned into pigs. Strange, dark, ghostly figures appear in all the shops and streets, frightening Chihiro and separating her from the pigs that were her parents. Chihiro runs back to the river, which was nearly dry when they came over but is now full and large, and she doesn't even recognize the buildings on the far side. As a riverboat approaches, she notices that her body has become transparent.The riverboat lands a big crowd of people in costume -- or maybe they're not people; at first they're only visible as paper masks. Chihiro thinks shes dreaming, but can't wake up. The boy who warned her away finds her and tells her she must eat some food from his world or she'll fade away. He assures her that she won't turn into a pig. She swallows the morsel he gives her and becomes solid, but finds that she's stuck to the ground until he recites an incantation to release her. A bird with a woman's head flies above them and he hides her, saying the bird is looking for her. They run through alleys and the pig barn to the big bathhouse, which is accessed by a bridge; the boy says she has to hold her breath as they cross the bridge or the spell that makes her invisible will be broken. Customers -- fantastically varied gods and spirits -- are crossing the bridge and being greeted by bathhouse staff. Chihiro makes it almost all the way across, but a frog (voice: Bob Bergen) that speaks to her companion (calling him Haku) startles her and she takes a breath. Luckily only the frog seems to see her, and Haku uses magic to encase it in a bubble to shut it up.Haku tells her to find Kamajii (voice: David Ogden Stiers), the boiler man, and make him give her a job; she must have a job to stay at the bathhouse, or else Yubaba (voice: Suzanne Pleshette), the old witch who rules the bathhouse, will turn her into an animal. And Haku says she has to stay if she wants to find and help her parents, who are still pigs, wherever they are. He knows her name and says he's known her since she was very small.Chihiro descends a steep, winding, rail-less wooden stairway in search of Kamajii and the boiler room. When she finds them, she sees a weird set-up in which the boiler is fed by creatures like spiders (delivering coal one lump at a time) and the machinery is controlled by a bearded, bald man 
 Question: Who used the black slug to control Haku?
answer:

yubaba