In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Ex Input:
Paragraph: The objectives of this study were to evaluate the effects of free-access acidified milk replacer feeding on the pre-and postweaning health of dairy and veal calves. Individually housed calves were systematically assigned at birth to 1 of 2 feeding programs: free-access feeding (ad libitum) of acidified milk replacer (ACD, n = 249) or traditional restricted feeding (3 L fed twice daily) of milk replacer (RES, n = 249). Calves were fed milk replacer containing 24% crude protein and 18% fat. Acidified milk replacer was prepared to a target pH between 4.0 and 4.5 using formic acid. Calves were weaned off milk replacer at approximately 6 wk of age. Weaning occurred over 5 d, and during this weaning period, ACD calves had access to milk replacer for 12 h/d and RES calves were offered only one feeding of milk replacer (3 L) daily. Calves were monitored daily for signs of disease. Fecal consistency scores were assigned each week from birth until weaning. A subset of calves was systematically selected for fecal sampling at 3 time points between 7 and 27 d of age. Fecal samples were analyzed for enterotoxigenic Escherichia coli F5, Cryptosporidium parvum, rotavirus, and coronavirus. Hip width, hip height, body length, heart girth, and body weight were measured at birth and weaning. Postweaning body weight measurements were collected from the heifers at approximately 8 mo of age. Postweaning body weight and carcass grading information was collected from the veal calves at slaughter once a live weight between 300 and 350 kg had been achieved. The odds of ACD calves being treated for a preweaning disease event tended to be lower than that of the RES calves (1.2 vs. 5.2%, respectively). Preweaning mortality, postweaning disease treatment, and postweaning mortality did not differ between feeding treatments. The ACD feeding treatment supported greater preweaning average daily gain (0.59 vs. 0.43 kg/d) and structural growth than RES feeding. Postweaning average daily gain and carcass characteristics were similar for ACD and RES calves. These results indicate that free-access acidified milk replacer feeding tended to support improved health, and greater body weight gain and structural growth during the preweaning period; these effects did not persist in the postweaning period. The growth advantage observed before weaning in the ACD calves likely disappeared due to the weaning methods used. 
 Title: Clinical trial on the effects of a free-access acidified milk replacer feeding program on the health and growth of dairy replacement heifers and veal calves

Ex Output:
True


Ex Input:
Paragraph: Delineation of the intricacies of protein function from macromolecular structure constitutes a continual obstacle in the study of cell and pathogen biology. Structure-based phylogenetic analysis has emerged as a powerful tool for addressing this challenge, allowing the detection and quantification of conserved architectural properties between proteins, including those with low or no detectable sequence homology. With a focus on viral protein structure, we highlight how a number of investigations have utilized this powerful method to infer common functionality and ancestry. 
 Title: Unraveling virus relationships by structure-based phylogenetic classification

Ex Output:
True


Ex Input:
Paragraph: The antigenic and biological properties of 6 strains of bovine coronavirus (BCV) derived from neonatal calf diarrhea (CD) and 8 strains of BCV from winter dysentery (WD) of adult cattle, propagated in HRT-18 cells, were compared to determine ifCD and WD strains belong to distinct serotypes or subtypes of BCV. All strains hemagglutinated both mouse and chicken erythrocytes at 4 °C, but the ratios of hemagglutination titers with mouse erythrocytes compared to chicken erythrocytes showed diversity for both CD and WD strains. Some CD and WD strains did not hemagglutinate chicken erythrocytes at 37 °C and showed receptordestroying enzyme activity against chicken erythrocytes. Hyperimmune antisera were produced in guinea pigs against 3 and 7 strains of BCV from CD and WD, respectively. No significant differences in antibody titers against these strains were observed by indirect immunofluorescence tests. However, in virus neutralization tests, antisera to 1 CD and 2 WD strains had 16-fold or lower antibody titers against 3 WD and 1 CD strains than against the homologous strains, and this variation reflected low antigenic relatedness values (R= 13-25%), suggesting the presence of different subtypes among BCV. In hemagglutination inhibition tests, some one-way antigenic variations among strains were also observed. These results suggest that some antigenic and biological diversity exists among BCV strains, but these variations were unrelated to the clinical source of the strains; i.e. CD or WD. Bovine coronavirus (BCV) is a primary cause of neonatal calf diarrhea (CD) worldwide [4, 13] . Bovine coronavirus is also associated with acute diarrhea in adult cattle during the winter season referred to as winter dysentery (WD) [4, 17, 18, 24, 26] . Besides infecting the small and large intestines of calves, BCV also possesses a tissue tropism for the upper respiratory tract [15] . H. Tsunemitsu and L. J. Saif Bovine coronavirus has four major structural proteins: the nucleocapsid protein (N), the transmembrane protein (M), the spike protein (S) and the hemagglutininesterase protein (HE) [21] . The S and HE proteins form fringes of longer and shorter surface projections, respectively [4] . Both proteins can cause hemagglutination (HA) and contain neutralizing epitopes [7, 20] . The HE protein also possesses receptor-destroying enzyme (RDE) which inactivates cellular receptors for BCV by hydrolyzing an ester bond to release acetate from C-9 of sialic acid [4, 27] . Because the primary isolation of BCV remains difficult, there have been only a few investigations on antigenic comparisons of BCV strains [6, 8, 11, 14] . Specifically, whether antigenic or biological differences exist between strains derived from CD and WD remains obscure [2] . The purpose of this study was to isolate BCV strains from feces derived from CD and WD in human rectal tumor (HRT-18) cells and to compare the antigenic and biological properties of these strains. and was propagated 8 times in HRT-18 cells. Six WD isolates of BCV designated as the TS, CN, BE, BM, AW and BW strains, were isolated from fecal samples of gnotobiotic calves which had been inoculated with fecal filtrates from affected adult dairy cows from 6 herds in the U.S.A. including Ohio (3 herds) and Wisconsin (3 herds), which were experiencing typical outbreaks of WD during the winters of 1987 to 1993. Three CD isolates of BCV designated as the DB2, OHC and SDC strains, were isolated from fecal samples of neonatal calves with acute diarrhea from 3 herds in the U.S.A. including Ohio (2 herds) and South Dakota (1 herd). A fourth CD isolate (JAZ) was isolated from a neonatal calf with acute diarrhea in Hokkaido, Japan. Virus isolation on HRT-18 cells was done as previously described [2, 25] except that 10 gg/ml of pancreatin (Gibco Laboratories, Grand Island, N.Y.) was added to the maintenance medium. Confirmation of the isolates as BCV was done by using immune electron microscopy [ 16] and immunofluorescence (IF) [2] with hyperimmune antiserum prepared against the Mebus strain ofCD BCV. The isolated viruses, which were passaged a total of 5 to 10 times in HRT-18 cells were plaque-purified at least once before use. Hyperimmune antisera were prepared in guinea pigs against 3 CD strains (Mebus, DB2, 216XF) and 7 WD strains (SD, BM, CN, AW, DBA, TS, BE) of BCV that had been propagated in HRT-18 cells for 6 to 11 passages and then purified on sucrose gradients [5] . These antisera were used for serological tests. Hemagglutination (HA) tests were conducted by the microtiter method [19] . Bovine coronavirus strains were purified from infected-cell culture supernatants, 
 Title: Antigenic and biological comparisons of bovine coronaviruses derived from neonatal calf diarrhea and winter dysentery of adult cattle Brief Report

Ex Output:

True