Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
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Question: Context: To determine the efficacy and safety of different doses of secukinumab, a fully human monoclonal antibody for targeted interleukin-17A blockade, in patients with noninfectious uveitis. Three multicenter, randomized, double-masked, placebo-controlled, dose-ranging phase III studies: SHIELD, INSURE, and ENDURE. A total of 118 patients with Behcet's uveitis (SHIELD study); 31 patients with active, noninfectious, non-Behcet's uveitis (INSURE study); and 125 patients with quiescent, noninfectious, non-Behcet's uveitis (ENDURE study) were enrolled. After an initial subcutaneous (s.c.) loading phase in each treatment arm, patients received s.c. maintenance therapy with secukinumab 300 mg every 2 weeks (q2w), secukinumab 300 mg monthly (q4w), or placebo in the SHIELD study; secukinumab 300 mg q2w, secukinumab 300 mg q4w, secukinumab 150 mg q4w, or placebo in the INSURE study; or secukinumab 300 mg q2w, secukinumab 300 mg q4w, secukinumab 150 mg q4w, or placebo in the ENDURE study. Reduction of uveitis recurrence or vitreous haze score during withdrawal of concomitant immunosuppressive medication (ISM). Other end points included best-corrected visual acuity, ISM use (expressed as a standardized ISM score), and safety outcomes. After completion or early termination of each trial, there were no statistically significant differences in uveitis recurrence between the secukinumab treatment groups and placebo groups in any study. Secukinumab was associated with a significant reduction in mean total post-baseline ISM score (P = 0.019; 300 mg q4w vs. placebo) in the SHIELD study. Likewise, secukinumab was associated with a greater median reduction in ISM score versus placebo in the INSURE study, although no statistical analysis of the difference was conducted because of the small sample size. Overall, there was no loss in visual acuity reported in any treatment group during follow-up in all 3 studies. According to descriptive safety statistics, the frequencies of ocular and nonocular adverse events seemed to be slightly higher among secukinumab groups versus placebo across the 3 studies. The primary efficacy end points of the 3 studies were not met. The secondary efficacy data from these studies suggest a beneficial effect of secukinumab in reducing the use of concomitant ISM. 
 Question: Which molecule is targeted by a monoclonal antibody Secukinumab?

Answer: interleukin-17a


Question: Context: The war had three phases. Initially it was a localized feud between supporters of Gebhard and those of the Catholic core of the Cathedral Chapter. With the election of Ernst of Bavaria as a competing archbishop, what had been a local conflict expanded in scale: Ernst's election guaranteed the military, diplomatic, and financial interest of the Wittelsbach family in the Electorate of Cologne's local affairs. After the deaths of Louis VI, Elector Palatine in 1583and William the Silent in 1584, the conflict shifted gears again, as the two evenly matched combatants sought outside assistance to break the stalemate. Finally, the intervention of Alexander Farnese, Duke of Parma, who had at his command the Spanish Army of Flanders, threw the balance of power in favor of the Catholic side. By 1588, Spanish forces had pushed Gebhard from the Electorate. In 1588 he took refuge in Strassburg, and the remaining Protestant strongholds of the Electorate fell to Parma's forces in 1589. 
 Question: After Louis VI, Elector Palatine, and Williant the Silent died, what set into motion the third phase of the war?

Answer: the intervention of alexander farnese


Question: Context: TODAY, Friday, November 12 JAZZ with the Mike Thomas Jazz Band at The Derby Arms. Upper Richmond Road West, Sheen. DISCO Satin Sounds Disco. Free at The Lord Napier, Mort lake High St., from 8a. m. to 8p. m. Tel: 682--1158. SATURDAY, November 13 JAZZ Lysis at The Bull's Head, Barnes. Admission 60p. MUSICAL HALL at The Star and Garter, Lower Richmond Road, Putney, provided by the Aba Daba Music Hall company. Good food and entertainment fair price. Tel: 789--6749. FAMILY night out? Join the sing-along at The Black Horse. Sheen Road, Richmond. JAZZ The John Bennett Big Band at The Bull's Head, Barnes. Admission 80p. THE DERBY ARMS, Upper Richmond Road West, give you Joe on the electric accordion . Tel: 789--4536 SUNDAY, November 14 DISCO Satin Sounds Disco, free at The Lord Napier, Mort Lake High Street, from 8 a. m. to 8 p. m. FOLK MUSIC at The Derby Arms. The Short Stuff and residents the Norman Chop Trio. Non-remembers 70p. Tel: 688--4626. HEAVY MUSIC with Tony Simon at The Bull, Upper Richmond Road West, East Sheen. THE DERBY ARMS, Upper Richmond Road West, give you Joe on the electric accordion. 
 Question: You want to spend the Saturday by joining the entertainment with your family. Where should you go?

Answer:
the sing-along at the black horse.