Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
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Question: Context: The film opens in Tokyo, where 27-year-old office worker Taeko Okajima, is planning to take a 10-day vacation. Having previously visited her sister's husband's farm in Yamagata. She had a good time there before, and has decided to go back again.As she prepares for her trip, her mind drifts back to her youth, when she was 10-years-old. After school lets out, almost all of Taeko's classmates have interesting places they are going to go to, but Taeko does not. When she brings this up to her family, they suggest that Taeko go with the family's Grandmother to a hot springs resort.Taeko eagerly goes with her Grandmother, but finds herself bored when all her Grandmother wishes to do is relax in their room. Taeko goes exploring the myriad baths in the resort by herself, but due to either the overwhelming beauty of one bath (or the heat of the baths), she passes out.While packing, she receives a call from her older sister whose husband owns the farm, and they have a laugh over the past incident.On her way to the train to the farm, Taeko passes by a fruit stand, and is reminded of when the family received a pineapple.This also happened during her 10th year, and she recalls how almost noone knew how to properly cut it. Her father decreed that it would not be touched until it was found out, and a few days later, one of Taeko's sister finds out. There is much eagerness once it is sliced into pieces, but slowly, the family quickly discerns they do not like its taste. Taeko attempts to stomach the pieces she has, and her sisters give her their pieces. In the end, the family concluded that the banana is the "king of fruits."Making it to the train station, Taeko also recalls more about the year 1966, when she was 10-years-old. With the popularity of the Beatles in full-swing, her sisters became enamored with the trends of the time. Her sister Nanako was in art school, and kept up with trends, including wearing a mini-skirt. Her other sister Yaeko had a small crush on an actress in a female acting troupe. However, while her sisters remember these things fondly, Taeko recalls she was too young to really get into these trends like her older sisters.One day after showing her Mother her grades, her Mother finds leftovers from her lunch, and expresses her disappointment in her daughter being picky, and not finishing her food. The next day at lunch, she is sitting next to a boy who is fine with finishing the radish and onion portion of his meal, but dislikes finishing his milk (per school rules, a student can only leave one item to be thrown away from their meal). Taeko offers to give him her radish and onions, and she'll finish his milk. The two quickly make a trade, but Taeko quickly finds that though she has no problems drinking milk, there's a bit too much for her to enjoy a second bowl.Afterwards, Taeko and several of her friends take part in a classroom debate. The topics cover everything from running in the halls, to handling leftovers. Not much is done regarding the issues, and there is much bickering and yelling.After remembering these things, the adult Taeko boards her train for the farm.Once aboard, her memories shift back to an encounter, where three girls from another class gigglingly inform her that a boy in their class named Hirota likes her. Taeko has no idea who Hirota, and her friends show her some graffiti near the school, showing Taeko and Hirota's name under an umbrella-like drawing. Her friends do some research, and find out that Hirota is a good pitcher for his classroom's baseball team.One day, both Taeko and Hirota's classes are pitted against each other in a baseball game.Hirota's female classmates eagerly chant that Taeko is watching, and Taeko's friends cheer for their own homeroom team, in defiance of the other girls. During the game, the cold gets to Takeko, and she rushes for the 
 Question: What city was Taeko traveling to?

Answer: yamagata.


Question: Context: Christianson syndrome (CS) is an X-linked neurodevelopmental and neurological disorder characterized in males by core symptoms that include non-verbal status, intellectual disability, epilepsy, truncal ataxia, postnatal microcephaly and hyperkinesis. CS is caused by mutations in the SLC9A6 gene, which encodes a multipass transmembrane sodium (potassium)-hydrogen exchanger 6 (NHE6) protein, functional in early recycling endosomes. The extent and variability of the CS phenotype in female heterozygotes, who presumably express the wild-type and mutant SLC9A6 alleles mosaically as a result of X-chromosome inactivation (XCI), have not yet been systematically characterized. Slc9a6 knockout mice (Slc9a6 KO) were generated by insertion of the bacterial lacZ/-galactosidase (-Gal) reporter into exon 6 of the X-linked gene. Mutant Slc9a6 KO male mice have been shown to develop late endosomal/lysosomal dysfunction associated with glycolipid accumulation in selected neuronal populations and patterned degeneration of Purkinje cells (PCs). In heterozygous female Slc9a6 KO mice, -Gal serves as a transcriptional/XCI reporter and thus facilitates testing of effects of mosaic expression of the mutant allele on penetrance of the abnormal phenotype. Using -Gal, we demonstrated mosaic expression of the mutant Slc9a6 allele and mosaically distributed lysosomal glycolipid accumulation and PC pathology in the brains of heterozygous Slc9a6 KO female mice. At the behavioral level, we showed that heterozygous female mice suffer from visuospatial memory and motor coordination deficits similar to but less severe than those observed in X-chromosome hemizygous mutant males. Our studies in heterozygous Slc9a6 KO female mice provide important clues for understanding the likely phenotypic range of Christianson syndrome among females heterozygous for SLC9A6 mutations and might improve diagnostic practice and genetic counseling by helping to characterize this presumably underappreciated patient/carrier group. 
 Question: Mutation of which gene is implicated in the Christianson syndrome?

Answer: slc9a6


Question: Context: Susceptibility to autoimmune disorders results from the interaction of multiple genetic factors that regulate the threshold of autoreactivity. Genome-wide microsatellite screens and large-scale single nucleotide polymorphism (SNP) association studies have identified chromosomal loci that are associated with specific disorders including systemic lupus erythematosus, rheumatoid arthritis, juvenile arthritis, multiple sclerosis, and diabetes. Numerous candidate gene association studies have in turn investigated the association of specific genes within these chromosomal regions, with susceptibility to autoimmune diseases (e.g. FcgammaReceptors, TYK2 and systemic lupus). More recently, large-scale differential gene expression studies performed on selected tissues from patients with autoimmune disorders, have led to the identification of gene signatures associated with the activation of specific pathways in these diseases (e.g. interferon signature in lupus). In the future, integrated analyses of gene (and protein) expression together with SNP data will allow us to sketch an intelligible picture of the genesis of autoimmunity in humans. This review sets out to illustrate how the most recent advances in the field of systemic lupus erythematosus, rheumatoid arthritis and juvenile arthritis have led to a better understanding of these disorders. 
 Question: Which is the most common gene signature in Rheumatoid Arthritis patients?

Answer:
ifn signature