In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Ex Input:
Paragraph: So far, there has been scarce information about the status of immunoglobulins (Ig) and the gene expression of inflammatory cytokines in buffaloes showing digestive troubles. The purpose of the present study was to explore the modulation of gene expression of some immuneinflammatory markers in buffaloes suffered from various digestive disorders. For this reason, 50 native breed water buffaloes were studied. Forty of these buffaloes showed various symptoms of digestive disorders and were allocated into 4 groups of equal sizes (group 1: uncategorized stomatitis; group 2: acute traumatic reticuloperitonitis [TRR]; group 3: acute rumen impaction; and group 4: undifferentiated enteritis). Ten apparently healthy buffaloes were randomly selected and considered as a control group. RNA was firstly extracted from the whole blood then a reverse transcription kits was used to convert the RNA to cDNA. Real-time PCR was used to measure the expression of mRNAs of interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor (TNF)-α, IgG, and IgA, while glyceraldehyde-3-phosphate dehydrogenase (GAPDH) used as an internal reference. The results of realtime PCR revealed a significant (P ≤ 0.05) upregulation of the gene expression of IL-1β, IL-6, IL-10, and TNF-α in blood of diseased buffaloes compared with those of controls. Animals showing acute TRP had peak values of both IL-6 and IL-10; while those exhibiting enteritis and rumen impaction had the highest values of IL-1β and TNF-α, respectively. The results of qPCR also revealed a significant (P ≤ 0.05) downregulation of both IgG and IgA gene expression in blood of all diseased buffaloes compared with controls. The lowest values of both genes were recorded in buffaloes showing acute TRP. The results herein suggest that the tested genes could have a pivotal role in the pathophysiologic mechanism of the underlying diseases. 
 Title: Modulation of immunity and inflammatory gene expression in buffalo (Bubalus bubalis) with some digestive disorders

Ex Output:
True


Ex Input:
Paragraph: The nucleoprotein-encoding gene (N) of murine hepatitis virus type 3 (MHV 3), from the Mill Hilt strain, was cloned and sequenced. It was compared to gene N from other routine coronaviruses and was found to share more similarities with N sequences from MHV 1 and MHV JHM strains than with the published MHV3 N sequence which is almost identical to MHVA59. We suggest that the evolution of some MHV N sequences resulted from a double recombination phenomenon between two ancestors. Furthermore, comparison of protein N from avian and mammalian coronaviruses leads to the hypothesis that horizontal transfer events of the virus from one host species to another have occurred. 
 Title: The gene encoding the nucleocapsid protein: sequence analysis in murine hepatitis virus type 3 and evolution in Coronaviridae

Ex Output:
True


Ex Input:
Paragraph: The giant triton snail (Charonia tritonis) is one of the few natural predators of the adult Crown-of-Thorns starfish (COTS), a corallivore that has been damaging to many reefs in the Indo-Pacific. Charonia species have large salivary glands (SGs) that are suspected to produce either a venom and/or sulphuric acid which can immobilize their prey and neutralize the intrinsic toxic properties of COTS. To date, there is little information on the types of toxins produced by tritons. In this paper, the predatory behaviour of the C. tritonis is described. Then, the C. tritonis SG, which itself is made up of an anterior lobe (AL) and posterior lobe (PL), was analyzed using an integrated transcriptomics and proteomics approach, to identify putative toxin-and feeding-related proteins. A de novo transcriptome database and in silico protein analysis predicts that ~3800 proteins have features consistent with being secreted. A gland-specific proteomics analysis confirmed the presence of numerous SG-AL and SG-PL proteins, including those with similarity to cysteine-rich venom proteins. Sulfuric acid biosynthesis enzymes were identified, specific to the SG-PL. Our analysis of the C. tritonis SG (AL and PL) has provided a deeper insight into the biomolecular toolkit used for predation and feeding by C. tritonis. If a generalist predator evolves to a more a specialist diet, it is assumed that it would be accompanied by modifications of characters that permit greater efficiency in capturing specific prey species. These likely include foraging behaviors and search strategies with fine-tuned chemosensory systems, physiological processes associated with digestion and waste removal, and other features involved with prey capture 1 . Among predatory taxa the evolution of a specialized diet is likely to be strongly linked to the evolution of venoms used to subdue prey. Although the evolution of many of these characters may be difficult to trace for a species that has evolved a restricted diet, the evolution of venoms can be inferred from analyses of expression of genes encoding venom and digestion components 2, 3 . Marine organisms from a broad range of phyla, from bacteria and algae to invertebrates and vertebrates, are known to produce toxins with high chemical diversity, divergence of which is likely driven by speciation and diet 4-6 . Some examples include tetrodotoxins produced by bacteria found in the saliva of the blue-ringed octopus and puffer fish 7, 8 , potent pore-forming toxins produced by cnidarians 9 , okadaic acid produced by bacteria in marine sponges 10 , and saponins (steroidal and triterpenoid) that are produced by echinoderms 11 . Venoms, and in particular specific toxins, play multiple roles from foraging to defense and intraspecific conflict 12 . Although there are many species of predatory marine snails, studies of venom toxins have been restricted to species within the superfamily Conoidea 13 . These venomous marine cone snails synthesize a remarkable diversity of pharmacologically active small peptides (conotoxins) to enable prey capture, self-defense and intra-specific competition 14-16 . The potency and selective profiles of the conotoxins vary depending on species targets that may include various subtypes of voltage-and ligand-gated ion channels, G protein-coupled receptors and neurotransmitter transporters 17 . Gastropods of the superfamily Tonnoidea are effective predators and thought to capture prey through envenomation 18 . Within the Tonnoidea, several species in the Cassidae family of snails are specialist predators of echinoderms. The large paired and mono-lobed salivary gland (SG) of Cassidae family snails are known to be toxic and inject a strong acid or venomous saliva into their prey to paralyse them before consumption [19] [20] [21] . For example, Cassidae helmet shell snails secrete an acidic saliva to soften the body wall of their preferred prey, sea urchin 22, 23 , Published: xx xx xxxx OPEN www.nature.com/scientificreports/ 2 Scientific RepoRts | 7: 6000 | 
 Title: Multiomics analysis of the giant triton snail salivary gland, a crown- of-thorns starfish predator OPEN

Ex Output:

False