In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Example Input: Question: The pyruvate carboxylase activity depends on the positive allosteric effector: 
 Options:  <1> Succinate <2> AMP. <3> Isocitrate. <4> Citrate. <5> Acetyl CoA
Example Output: 5

Example Input: Question: Regarding intestinal polyposis, which of the following syndromes is NOT hereditary? 
 Options:  <1> Gardner syndrome. <2> Cronkhite-Canada syndrome. <3> Turcot syndrome. <4> Juvenile polyposis <5> Peutz-Jeghers syndrome.
Example Output: 2

Example Input: Question: The transmembrane proteins that bind to intracellular and extracellular proteins are: 
 Options:  <1> Ocludines. <2> Cadherins. <3> Actins. <4> Integrins <5> Desmocolinas.
Example Output:
4