Given a passage with a context and an answer, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.

[EX Q]: Context: The aim of this study was to evaluate how closely analysis of bone quality performed using the bone mineral density (BMD) values obtained by quantitative computerized tomography (QCT) reflected the histologic bone density.', "Eighteen patients requiring implant therapy underwent CT scanning. Their data were processed using Image Master software, and the BMD was calculated by measuring the Hounsfield units and relating those values to a phantom (Calibration Phantom, Quantitative Technologies). Each patient wore a radiographic-surgical template in which titanium cylinders were placed as a drilling guide for preparation of the implant site. The mouth regions where the titanium guides were placed (on the CT images and in the patient's mouth) corresponded to the implant sites where the BMD was measured and where tissue specimens for histomorphometric analysis retrieved. Forty specimens measuring 6 mm in length and 2 mm in diameter were obtained. Histomorphometric analysis was performed by digitizing the images, which were subsequently analyzed using the image analysis software IAS 2000. The bone volume (BV) was calculated as a percentage by dividing the area occupied by the mineralized bone over the entire microscopic field.", 'The results of the statistical analysis showed a Pearson correlation coefficient of 0.691 between the BV and BMD values, with a P value < 0.01, which was considered significant.
Answer: The results of this study support the use of QCT to assess the bone quality before implant placement to improve the planning of implant treatment.
[EX A]: Are bone mineral density and bone histomorphometry statistically related?

[EX Q]: Context: This study was designed to investigate the effects of simvastatin in a rat model of acute myocardial infarction.', 'Male Wistar rats were anesthetized (thiopentone sodium 120 mg/kg). After a thoracotomy, the left-anterior-descending coronary artery (LAD) was occluded (for 25 min) and reperfused (for 120 min). Area at risk (AR) was determined with Evans Blue dye and infarct size after staining of the area at risk with nitroblue tetrazolium.', 'In rats, which received the vehicle for simvastatin (10% DMSO, 1 ml/kg i.v. at 1 h prior to the occlusion of the LAD), occlusion of the LAD for 25 min followed by reperfusion for 2 hours resulted in an infarct size of 54 +/- 4% (n=7) of the AR. When compared with vehicle, administration of simvastatin (1 mg/kg i.v. bolus administration at 1 h prior to the onset of myocardial ischemia) caused a significant reduction in myocardial infarct size of 39%. LAD-occlusion and reperfusion caused a progressive fall in mean arterial blood pressure (when compared with sham-operated animals). Simvastatin had no significant effect on blood pressure.
Answer: The result indicates that simvastatin, an inhibitor of HMG-CoA reductase and a ligand of PPAR-a and PPAR-g, reduces the tissue necrosis associated with acute myocardial infarction. We propose that statins may be useful in conditions associated with ischemia-reperfusion of the heart and other organs.
[EX A]: Does simvastatin reduce infarct size in a model of acute myocardial ischemia and reperfusion in the rat?

[EX Q]: Context: This study was undertaken to assess the presence and degree of anxiety and depression in a group of UK patients with primary Sjögren's syndrome (1 degrees SS).", 'Cross-sectional.', 'Department of Oral Medicine, Liverpool University Dental Hospital.', 'Eighty adult patients; 40 diagnosed with 1 degrees SS according to the revised European Criteria and 40 age/gender-matched controls with no history of chronic illness.', 'Hospital Anxiety and Depression Scale (HADS), a self-administered questionnaire designed to evaluate the presence and degree of anxiety and depression in a clinical setting.', 'Age, gender, Hospital Anxiety and Depression Scale (HADS).', "Forty patients with 1degrees SS and 40/age/gender-matched controls completed the HADS. Scores for anxiety in both the 1 degrees SS and control groups showed no statistically significant difference. Patients with 1 degrees SS had statistically significant higher, mean HADS scores for depression than the controls. There was an increased prevalence of 'definite' clinical depression in the 1 degrees SS group.
Answer: Patients with 1 degrees SS appear to be at increased risk from clinical depression. Early recognition and appropriate intervention is therefore essential to reduce the negative impact of depression on the patient's quality of life and outcome of their disease.
[EX A]:
Are uK patients with primary Sjögren 's syndrome at increased risk from clinical depression?