instruction:
Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
question:
Tacrolimus was substituted for cyclosporine on day 20; on day 21 amlodipine was initiated to manage hypertension.
answer:
non-adverse drug event


question:
Dopamine agonists are increasingly used in the treatment of Parkinson disease, but they may cause serious adverse effects.
answer:
non-adverse drug event


question:
Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.
answer:

adverse drug event