TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disease in adults. Classical ALS is characterized by the death of upper and lower motor neurons leading to progressive paralysis. Approximately 10% of ALS patients have familial form of the disease. Numerous different gene mutations have been found in familial cases of ALS, such as mutations in superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP-43), fused in sarcoma (FUS), C9ORF72, ubiquilin-2 (UBQLN2), optineurin (OPTN) and others. Multiple animal models were generated to mimic the disease and to test future treatments. However, no animal model fully replicates the spectrum of phenotypes in the human disease and it is difficult to assess how a therapeutic effect in disease models can predict efficacy in humans. Importantly, the genetic and phenotypic heterogeneity of ALS leads to a variety of responses to similar treatment regimens. From this has emerged the concept of personalized medicine (PM), which is a medical scheme that combines study of genetic, environmental and clinical diagnostic testing, including biomarkers, to individualized patient care. In this perspective, we used subgroups of specific ALS-linked gene mutations to go through existing animal models and to provide a comprehensive profile of the differences and similarities between animal models of disease and human disease. Finally, we reviewed application of biomarkers and gene therapies relevant in personalized medicine approach. For instance, this includes viral delivering of antisense oligonucleotide and small interfering RNA in SOD1, TDP-43 and C9orf72 mice models. Promising gene therapies raised possibilities for treating differently the major mutations in familial ALS cases.

SOLUTION: Which human disease is associated with mutated UBQLN2

PROBLEM: A house of cards? Sounds unbelievable, doesn't it? Not if the architect is 31-year-old Bryan Berg. He's made a career out of building fantastic card houses, stadiums, capitols, castles -- and the world's tallest card tower. How does he do it? Bryan's structures are amazing because they are made entirely of perfectly balanced, freestanding playing cards. He never uses glue, tape, or anything else to hold the cards together. Nor does he fold the cards. He's discovered another way to make a strong house of cards, using a trick from nature. To make plants strong, nature builds them with cells that have tough walls. Rows and rows of these cells form a grid that helps leaves and stems keep their shape. Bees use the same kind of repeating pattern to create strong honeycombs, where they live and store honey. Bryan designs similar grids, using cards to create a repeating pattern of cells. He begins with a single cell made by balancing four cards against one another to form a box. Then he repeats the cell over and over, expanding outward to form the grid, which makes a good foundation for a strong card structure. The larger the grid, the more weight it can carry. Sometimes Bryan uses several cards, instead of just one, to construct the cell walls, making the grid even stronger. The trick, he tells kids when he speaks in classrooms, is to place your cards as tightly together as possible when laying out your grid, making sure the cards are not leaning at all. After building this solid base, Bryan lays cards across the top to make the floor for the next "story" of the building. He may add towers, columns, steeples, or domes. Using the principle of repeating cells, Bryan builds structures of amazing strength. In the Cards Not surprisingly, Bryan has always been interested in building things. Growing up on a "big, old farm" in rural Iowa, he had plenty of room to play. "We were in the middle of nowhere," Bryan remembers, "with lots of space to do whatever we wanted. I was always making something, using things like sticks or bales of hay." Bryan's grandfather taught him how to stack cards. Bryan's two interests -- building and card stacking -- soon combined. But stacking in his family's farmhouse was challenging. "Our old house had wood floors that weren't all level," he reports. "And they weren't very firm. When people walked around, it was like 'earthquake action.' It was a challenge to build something that wouldn't fall down immediately." Bryan constructed tower after tower; he went through a lot of trial and error before he built anything taller than himself. When he placed a few decks of cards on top of his grid, he discovered how strong it was. Bryan's towers began to grow taller. How Tall Is Too Tall? Bryan's first Guinness World Record for the world's tallest card tower came in the spring of 1992, when he was in high school. Learning that the world record was 12 feet 10 inches, Bryan built a slim tower that topped out at 14 feet 6 inches. Done as a project for his geometry class, it took him 40 hours and 208 decks of cards. Since then he's gone on to win world records for even taller buildings. His latest winner measured 25 feet 3.5 inches and used about 2,400 decks of cards. _ Why don't these towers fall down? The key is in a good solid base, a repeating pattern of stories, and a tapering top. Bryan likes to point out how card buildings resemble real ones. They are built cell by cell, story by story. The separate parts make one strong whole. The heavier the building, the stronger and more stable it is. But the weight can't all be at the top. After spending so much time building something so cool, Bryan admits it's sometimes painful to see his structures destroyed. But he compares his work to the building of a sandcastle or an ice sculpture.

SOLUTION: What was Bryan's first world record?

PROBLEM: The 49ers would trail 20-13 with less than a minute to go. Blaine Gabbert would run in a game-tying 44 yard touchdown to tie the game at 20. The Bears appeared to have the game won when they went down the field after a decent kick return by Deonte Thompson for 74 yards. Robbie Gould came out to attempt a game-winning 36 yard field goal, but the kick was wide left, resulting in overtime. In the overtime period, Gabbert would throw the game-winning 71-yard touchdown pass to Torrey Smith to win the game for San Francisco. This was San Francisco's first win in Chicago since the 1989 NFC Championship Game.

SOLUTION:
Who threw the longest touchdown pass in overtime?