Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.
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Question: The U.S. Food and Drug Administration questioned the differences in size and formulation of the patch used in trials and the to-be-marketed patch. The generic drugs maker, which received a “complete response letter” from the FDA, said it planned to work closely with the agency to address the questions. Such letters typically lay out FDA concerns that need to be addressed before a treatment is approved. Actavis’ contraceptive skin patch is designed to provide continuous delivery of the hormone norethindrone, a type of progestin, during a once-weekly, seven-day dosing regimen. Progestin, the synthetic form of female sex hormone progestogen, inhibits ovulation and thickens the layer of mucus at the cervix so sperm cannot enter the uterus. The treatment will compete with Johnson and Johnson’s Ortho Evra, an estrogen/progestin combination contraceptive patch. Estrogen is another female sex hormone. A progestin-only patch can be safer than combination patches as high levels of estrogen are often linked to blood clotting disorders and an increased risk of cancer. The company also filed on Tuesday an application to market the generic version of Merck & Co Inc’s NuvaRing, a estrogen/progestin combination hormonal contraceptive vaginal ring. Actavis said it may be the first applicant to file the application, which, if approved may entitle it to 180 days of generic market exclusivity. Shares of Dublin, Ireland-based Actavis were down 0.6 percent at $165.16 in early trading on the New York Stock Exchange on Tuesday.

Answer: FDA rejects Actavis' contraceptive patch, seeks more data.


Question: The alert urged Americans to seek medical help in the event they suffered any “unusual, unexplained physical symptoms or events, auditory or sensory phenomena, or other health concerns.” The alert comes as a U.S. medical team is screening more Americans who work at the Guangzhou consulate. A previous case in Guangzhou, disclosed last month, prompted the tests. The incidents have raised fears the unexplained issues that started in Cuba in 2016 have expanded to other countries. China says it has uncovered no information that could point to a cause. The most recent evacuations followed medical testing that revealed they might have been affected. State Department spokeswoman Heather Nauert said “a number of individuals” had been brought to the U.S. but didn’t say how many were affected or evacuated. Friday’s alert called for people to be attentive of symptoms including “dizziness, headaches, tinnitus, fatigue, cognitive issues, visual problems, ear complaints and hearing loss, and difficulty sleeping.” It urged them “not to attempt to locate the source of any unidentified auditory sensation. Instead, move to a different location.” The U.S. government has deemed the Cuba incidents “specific attacks” on American workers but hasn’t publicly identified a cause or culprit. Most of the incidents were accompanied by bizarre, unexplained sounds that initially led U.S. investigators to suspect a sonic attack. Asked about the latest incidents, Chinese Foreign Ministry spokeswoman Hua Chunying said Thursday that the U.S. had not formally raised the matter with Beijing. “If the U.S. makes formal contact with us, China will continue necessary investigations in an earnest and responsible manner and maintain close communication and cooperation with the U.S.,” Hua said at a regularly scheduled news conference. China earlier said it had looked into the case announced last month but came up with no clues about the cause of the symptoms. A U.S. official, who wasn’t authorized to discuss the situation publicly and requested anonymity, said the evacuated American government workers were being brought from China for testing to the University of Pennsylvania. That’s where doctors have been treating and studying patients previously evacuated from the U.S. Embassy in Havana. The preliminary findings of the medical reports on the 24 personnel affected in Cuba showed they had sensory and memory problems similar to the brain dysfunction seen with concussions. The Penn team said the patients from Cuba experienced persistent disability though rehabilitation therapy customized for them seemed to help. Canada in April also ordered families of diplomatic staff in Cuba to return home after mysterious health symptoms were detected in 10 Canadians stationed on the island. Canada said the 10 continued to show unexplained brain symptoms and that “medical information raised concerns for a new type of a possible acquired brain injury.” In testimony before the Senate Foreign Relations Committee last month about the first case in China, U.S. Secretary of State Mike Pompeo said China had “said all the right things and have demonstrated their willingness to help us identify the vector which led to this medical incident.” The China incidents affect one of the most important of the seven U.S. diplomatic outposts in the country. The Guangzhou consulate opened months after the establishment of diplomatic relations between Beijing and Washington in 1979 and moved to its new purpose-built facility in 2013. It serves four southern provinces with a combined population of more than 204 million and processes more than 1 million visa applications of all types annually. It is also the only U.S. diplomatic installation in China authorized to process immigrant visas and handle adoptions. People working in The Canton Place complex, a few kilometers (miles) from the consulate, said Thursday they were just hearing about the incidents, reflecting a lack of coverage in China’s entirely state-controlled media. Aled Williams, a British teacher at a kindergarten said Thursday that the reports sounded “sci-fi-ish.” “Hard to get my head around how it works,” he said. “Better watch myself.” Linda Chen, who runs a coffee shop in the area, said she was mystified as to why only certain people seemed to have been affected in an area known for its comfort and safety. “For me I feel it’s very strange. But I don’t feel that there’s something to be very afraid of because it’s probably a very special case,” Chen said. ___ Associated Press writer Josh Lederman in Washington, D.C. contributed to this report.

Answer: US Embassy in China sends new alert for mystery health issue.


Question: Turkey reported its first infection just over two weeks ago. Since then, a surge in cases to 3,629 has outstripped rates in most other countries and the government has fallen short of its target to conduct 10,000 tests per day. In interviews with Reuters, experts have urged stronger stay-at-home orders and some said it was risky for Ankara to export 500,000 kits to the United States only to turn around and order a million more from China. “Our test numbers are low. We were certainly not prepared. Countries that are ready must have high test numbers,” said Sinan Adiyaman, chairman of the Turkish Medics Association (TTB). The government has said it took timely measures to delay the outbreak. But Adiyaman said Turkey was slow on some steps, including suspending sports leagues and quarantining those coming from abroad, especially the thousands returning this month from an Umrah pilgrimage. “Around 200,000 people arrived from abroad since the outbreak began, and they were just given a simple fever test and released across Turkey in an uncontrolled manner,” he said. “You cannot fight a pandemic this way.”  The coronavirus has so far killed 75 people in Turkey, an international crossroads with one of the world’s biggest airports in Istanbul. About 40,000 tests have been done including about 7,000 in the last 24 hours, suggesting Turkey is edging toward the target Health Minister Fahrettin Koca set out a week ago, but only two-thirds of the way there. South Korea, seen as the global leader, does more tests each day than Turkey’s total. (Click here here for a graphic of global tests; click here here for its global spread.) To contain the virus, Ankara has closed schools, cafes and bars, banned mass prayers, and suspended sports matches and flights. President Tayyip Erdogan said Turkey, which has a population of about 83 million, would overcome the outbreak in two to three weeks. Mustafa Cankurtaran, head of geriatrics at the Hacettepe University Faculty of Medicine, said his team is following the national guidelines, testing only “risky” patients with cough and fever. But next month will be critical since the outbreak will widen, he said. Earlier this week Koca said the kits sent to the United States were locally produced PCR tests for the coronavirus. He said Turkey had a monthly production capacity of 2 million tests, and added that the tests purchased from China were “rapid tests”, not PCR. The TTB’s Adiyaman said sending the test kits jeopardised the health of the public and medical personnel. “Exporting testing kits to the United States as Turkey needs them and while they need to be used here will be an unforgivable mistake,” he said. Irshad Shaikh, the World Health Organisation’s health security program Leader in Turkey, said the country now had little room for error and must test everyone who has had contact with the virus. He said, however, that the export of test kits to the United States, which he said was in a “perilous situation,” could be seen as a form of capital investment. “From now on, it’s a very slippery slope and razor-thin margin moving forward,” he said. “Now if the U.S. succeeds in vaccine development, we already have our invested cash in the bank in the form of our IOUs,” Shaikh told Reuters. Among the containment measures, Ankara said it quarantined Muslims returning from Umrah in Saudi Arabia. But Nihat Gonul, the local administrator of a village in  Sakarya province some 120 km east of Istanbul, said two returning pilgrims continued their lives normally and attended gatherings for days before authorities came to quarantine them. “There is this atmosphere of uncertainty in the village. People are scared, not sure what to think,” Gonul said.

Answer:
Turkey struggles to ramp up tests as outbreak reaches critical phase.