In this task, you are given a question and a context passage. You have to answer the question based on the given passage.

What needs to decrease before pituitary growth hormone can increase in the blood?, Context: In addition to the negative consequences of sleep deprivation, sleep and the intertwined circadian system have been shown to have strong regulatory effects on immunological functions affecting both the innate and the adaptive immunity. First, during the early slow-wave-sleep stage, a sudden drop in blood levels of cortisol, epinephrine, and norepinephrine induce increased blood levels of the hormones leptin, pituitary growth hormone, and prolactin. These signals induce a pro-inflammatory state through the production of the pro-inflammatory cytokines interleukin-1, interleukin-12, TNF-alpha and IFN-gamma. These cytokines then stimulate immune functions such as immune cells activation, proliferation, and differentiation. It is during this time that undifferentiated, or less differentiated, like naïve and central memory T cells, peak (i.e. during a time of a slowly evolving adaptive immune response). In addition to these effects, the milieu of hormones produced at this time (leptin, pituitary growth hormone, and prolactin) support the interactions between APCs and T-cells, a shift of the Th1/Th2 cytokine balance towards one that supports Th1, an increase in overall Th cell proliferation, and naïve T cell migration to lymph nodes. This milieu is also thought to support the formation of long-lasting immune memory through the initiation of Th1 immune responses.
cortisol, epinephrine, and norepinephrine

How many things may mirror things with effects?, Context: The three marks of existence may reflect Upanishadic or other influences. K.R. Norman supposes that the these terms were already in use at the Buddha's time, and were familiair to his hearers.
three

What did his thinking conflict with?, Context: In the early 11th century, the Muslim physicist Ibn al-Haytham (Alhacen or Alhazen) discussed space perception and its epistemological implications in his Book of Optics (1021), he also rejected Aristotle's definition of topos (Physics IV) by way of geometric demonstrations and defined place as a mathematical spatial extension. His experimental proof of the intromission model of vision led to changes in the understanding of the visual perception of space, contrary to the previous emission theory of vision supported by Euclid and Ptolemy. In "tying the visual perception of space to prior bodily experience, Alhacen unequivocally rejected the intuitiveness of spatial perception and, therefore, the autonomy of vision. Without tangible notions of distance and size for correlation, sight can tell us next to nothing about such things."

Aristotle's definition of topos