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Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.
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Paragraph: Scientists led by Ali Erturk at Ludwig Maximilians University in Munich have developed a technique that uses a solvent to make organs such as the brain and kidneys transparent. The organ is then scanned by lasers in a microscope that allows researchers to capture the entire structure, including the blood vessels and every single cell in its specific location. Using this blueprint, researchers print out the scaffold of the organ. They then load the 3D printer with stem cells which act as “ink” and are injected into the correct position making the organ functional. While 3D printing is already used widely to produce spare parts for industry, Erturk said the development marks a step forward for 3D printing in the medical field. Until now 3D-printed organs lacked detailed cellular structures because they were based on images from computer tomography or MRI machines, he said. “We can see where every single cell is located in transparent human organs. And then we can actually replicate exactly the same, using 3D bioprinting technology to make a real functional organ,” he said. “Therefore, I believe we are much closer to a real human organ for the first time now.”  Erturk’s team plan to start by creating a bioprinted pancreas over the next 2-3 years and also hope to develop a kidney within 5-6 years. The researchers will first test to see whether animals can survive with the bioprinted organs and could start clinical trials within 5-10 years, he said. Claim: German scientists create see-through human organs.
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Researchers in Germany have created transparent human organs using a new technology that could pave the way to print three-dimensional body parts such as kidneys for transplants.


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Paragraph: Shares of the company traded marginally down at $132.47, after having closed up 1.7% on Monday. (bit.ly/2ZkZGze)    J&J said that the FTC had issued a “civil investigative demand,” or CID, the equivalent of a subpoena to determine if the contracting practices were legal. Pfizer Inc filed a lawsuit against J&J in 2017, saying its rival’s contracts with health insurers for blockbuster rheumatoid arthritis drug, Remicade, were anticompetitive and aimed at blocking sales of Pfizer’s biosimilar called Inflectra. Pfizer said in the lawsuit that J&J had contracted with many insurers to give discounts in exchange for giving preference to Remicade, and to only pay for Inflectra in cases where Remicade proved to be ineffective. Inflectra was approved in 2016 while Remicade went on the market in 1998. Remicade is an infused treatment for chronic autoimmune disorders and costs about $4,000 per dose, or $26,000 a year, Pfizer said in the lawsuit. J&J has denied any wrongdoing and is fighting the Pfizer lawsuit. Pfizer said in a statement that it had received a CID in June. “As Pfizer’s complaint alleges, J&J’s unlawful conduct is designed to prevent Inflectra from being able to compete on its primary point of differentiation – price. Today, Inflectra has an average selling price (ASP) that is more than 22% lower than Remicade,” the company said in a statement. “Despite these facts, J&J has not lost substantial volume or share of sales – counter to what should occur in a competitive market.”  Biosimilars are intended to be lower-cost alternatives to expensive biotech medicines. But since they are made from living cells and it is not possible to make an exact copy of the branded medicine, they are not automatically substituted for the existing branded drug the way a generic drug would be. The drugs treat ailments like rheumatoid arthritis, Crohn’s disease and ulcerative colitis. Claim: J&J says FTC probing efforts to protect arthritis drug Remicade.
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The Federal Trade Commission issued civil subpoenas to Johnson and Johnson in June as part of an investigation into whether contracting practices for its blockbuster rheumatoid arthritis drug, Remicade, violated antitrust laws, the company said in a regulatory filing on Monday.


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Paragraph: With global warming widely expected to slash snowfall, especially at lower levels, the Swiss tourism industry is looking for ways to preserve a lucrative business brutally exposed to the weather. Enter Napa, Serbia’s last circus bear. The Arosa ski resort in eastern Switzerland has created a $6.5 million refuge hosting Napa and two other bears rescued from cages at restaurants in Albania to help draw summer visitors and reduce its reliance on skiers and snowboarders. School classes, families and a group of army veterans celebrating an 80th birthday were visiting one recent summer day, helping the park toward what Arosa tourism director Pascal Jenny said was a target of 50,000 visitors this year. Arosa has reinvented itself before - moving to winter tourism in the 1930s after decades as a health resort for tuberculosis patients. But with nearly 620,000 overnight stays in winter last year, more than three times the summer total — it will not be easy. Jenny, who fears a sharp decline in snowfall over the next 20 or 30 years, is hedging his bets. “What gives us some hope is that artificial snow is making strong technical advances. I can make snow now at 5 degrees above freezing,” he said, standing on an observation platform beside the Weisshorn cable car which gives a sweeping view of the snow-capped Alpine valley. His two-pronged approach highlights the dilemma faced by mountain resorts — how to retain profits as they embark on what the Organisation for Economic Co-Operation and Development (OECD) says needs to be a global rethink of tourism. “The consequences of climate change will be felt across the travel and tourism sector over the coming decades,” the OECD, whose member countries represent 80% of the world’s trade and investment, said in a 2018 study of megatrends in tourism. Storms, flooding and tidal surges will threaten coastal regions, southern destinations face extreme heatwaves and northern ones will see shorter periods of snowfall, it said. Mountain resorts tend to be higher in Switzerland than in Austria or France, giving them better chances as snow becomes scarcer. But even at 3,000 meters, pistes could see snow depths more than halved by 2100 if greenhouse gas emissions are not curbed, a report in The Cryosphere, a peer-reviewed geosciences journal named after the frozen water parts of the Earth, said. Resorts below 1,200 meters - as about a quarter of Alpine ones are - might get almost no snow, said the 2017 report, whose title starts “How much can we save?”. Snow levels will gradually stabilize if global temperature rises are contained, it says. Arosa is 1,775 meters up but Jenny worries that a loss of snow in the lowlands will cost it visitors because people will lose their emotional connection with snow. “That is almost more dangerous for the sector,” he said. Hence his interest in an industrial estate in Denmark, where Arosa is cooperating on a project to make artificial snow so that urban dwellers can learn to ski and then, he hopes, go on to hone their skills in the Alps. The economics are clear: a daily lift pass for skiers in Arosa costs 79 Swiss francs ($80.27), while a summer hiker or mountain biker typically pays 18 francs for a pass that lets them use a rope park, a swimming area and paddle boats on the town’s lake. Hotels and restaurants charge more in winter too, but the strong Swiss franc has priced many people out. Switzerland is one of the wealthiest countries in the world, and the Swiss government says the long-term outlook for tourism is healthy. “Mountain summers can position themselves as an alternative to the Mediterranean regions,” a 2017 report said. Summer tourism already accounts for 60% of overnight stays across Switzerland, but the season brings in only 18% of revenue, said Therese Lehmann, an economist at the University of Bern’s Centre for Regional Development. Government data already shows a 24% drop in skiers in the decade to 2016, with other factors as well as climate change. “The decline of ski tourism — a powerful economic engine — will have more of an impact than the additional revenue in summer,” said Dominik Siegrist, director of the Institute for Landscape and Open Space at Switzerland’s University of Applied Sciences Rapperswil. Europe’s population is aging and younger people are less interested in skiing. Snowshoeing, winter hiking, sledding and ski touring — in which people hike up mountains, are on the increase, industry lobby Swiss Tourism says. Consolidation of winter tourism is on the horizon, with overnight stays in bigger Swiss resorts up 1 percent in the decade to 2015, but down 17 percent in smaller ones. “Lots of smaller ones are grasping at straws, trying to survive as long as they can because the valleys depend on this tourism,” Siegrist said. Large resorts in the Swiss cantons of the Grisons and Valais, Austria’s Tyrol province and France’s Savoie region have the marketing pull to survive, Siegrist said, listing high- altitude Andermatt, Zermatt and St Moritz in Switzerland. The Andermatt Swiss Alps resort, in central Switzerland, is targeting cyclists in summer, and has also built new lifts to lure winter sports fans. It covers a nearby glacier with strips of artificial fleece in spring to help reduce melting and creates piles of snow higher than houses to deploy on ski pistes as early as November to avoid having to use expensive artificial snow. The strong Swiss franc has hit ski lifts focused on winter business from European visitors hard in the past 10 years, the government says, but the minority of lifts with strong summer business are booming thanks to visitors from overseas. Many smaller lift firms get cheap loans and, increasingly, state subsidies to help balance the books, said Lehmann. Roughly a third are debt-free, but depend on long-haul tourism, which she said was not ideal from an environmental point of view, because flights are a major contributor to holiday carbon emissions. “Maybe we have to get away from focusing solely on growth, and promote Alpine areas as good habitats for living, not just for tourism,” she said. Listed cable car companies Bergbahnen Engelberg Truebsee Titlis Bet AG (TIBN.S) and Jungfraubahn Holding AG (JFN.S), cite year-round visitors from Asia - especially China and India - as important sources of income. Asked about sustainability, Titlis marketing director Peter Reinle said the firm’s prospects were good for the next 50 years. “We as a single entity can not solve the whole climate problem. Politicians have to provide framework conditions.”  Jungfraubahn’s Corporate Secretary Christoph Schlaeppi said it employed 800 local people, helping to make life in the mountains economically sustainable for a new generation. The government says it is up to individual resorts to decide how much they want to attract Asian groups, but focuses its own promotion efforts on individual travelers and sustainability, noting Japanese tourists now come independently and stay longer. “We have to see that guests from Asia making the long flight to Europe or Switzerland stay as long as possible,” Richard Kaempf, head of tourism policy at the State Secretariat of Economic Affairs, told Reuters. While the government encourages year-round use of mountain infrastructure, he said it is not giving up on winter sports, a deep cultural touchstone for the Swiss. But he acknowledged the growing challenge of lowlanders losing the “winter feeling”. Claim: High and dry: Alpine resorts grapple with climate change.
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The prospect of searing heatwaves driving holidaymakers to cool mountains and children asking grandparents about their memories of snow is focusing minds in Alpine ski resorts on the implications of climate change.