Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Input: Consider Input: Context: Ca2+ is a ubiquitous intracellular messenger responsible for controlling numerous cellular processes including fertilization, mitosis, neuronal transmission, contraction and relaxation of muscles, gene transcription, and cell death. At rest, the cytoplasmic Ca2+ concentration [Ca2+]i is approximately 100 nM, but this level rises to 500-1,000 nM upon activation. In osteoblasts, the elevation of [Ca2+]i is a result of an increase in the release of Ca2+ from endoplasmic reticulum and/or extracellular Ca2+ influx through voltage gated Ca2+ channels. Many of the cellular effects of Ca2+ are mediated by the Ca2+ binding protein, calmodulin (CaM). Upon binding up to four calcium ions, CaM undergoes a conformational change, which enables it to bind to specific proteins eliciting a specific response. Calmodulin kinase II (CaMKII) is a major target of the Ca(2+)/CaM second messenger system. Once bound to Ca(2+)/CaM, the multimeric CaMKII is released from its autoinhibitory status and maximally activated, which then leads to an intraholoenzyme autophosphorylation reaction. Calcineurin (Cn) is another major target protein that is activated by Ca(2+)/CaM. Cn is a serine-threonine phosphatase that consists of a heterodimeric protein complex composed of a catalytic subunit (CnA) and a regulatory subunit (CnB). Upon activation, Cn directly binds to, and dephosphorylates nuclear factor of activated T cells (NFAT) transcription factors within the cytoplasm allowing them to translocate to the nucleus and participate in the regulation of gene expression. This review will examine the potential mechanisms by which calcium, CaM, CaMKII, and Cn/NFAT control osteoblast proliferation and differentiation. 
 Question: Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)?

Output: can


Input: Consider Input: Context: The Great Red Spot is a persistent anticyclonic storm on the planet Jupiter, 22 south of the equator, which has lasted for at least 186 years and possibly as long as 351 years or more. 
 Question: On what celestial body is Great Red Spot located?

Output: jupiter


Input: Consider Input: Context: You are on vacation at the beach. You take your flip-flops off so you can go swimming. The sand is so hot it hurts your feet. You have to run to the water. Now imagine if it were hot enough for the sand to melt. Some places inside Earth are so hot that rock melts. Melted rock inside the Earth is called magma. Magma can be hotter than 1,000C. When magma erupts onto Earths surface, it is known as lava, as Figure 3.17 shows. Minerals form when magma and lava cool. Most water on Earth, like the water in the oceans, contains elements. The elements are mixed evenly through the water. Water plus other substances makes a solution. The particles are so small that they will not come out when you filter the water. But the elements in water can form solid mineral deposits. Fresh water contains a small amount of dissolved elements. Salt water contains a lot more dissolved elements. Water can only hold a certain amount of dissolved substances. When the water evaporates, it leaves behind a solid layer of minerals, as Figure 3.18 shows. At this time, the particles come together to form minerals. These solids sink to the bottom. The amount of mineral formed is the same as the amount dissolved in the water. Seawater is salty enough for minerals to precipitate as solids. Some lakes, such as Mono Lake in California, or Utahs Great Salt Lake, can also precipitate salts. Salt easily precipitates out of water, as does calcite, as Figure 3.19 shows. The limestone towers in the figure are made mostly of the mineral calcite. The calcite was deposited in the salty and alkaline water of Mono Lake, in California. Calcium-rich spring water enters the bottom of the lake. The water bubbles up into the alkaline lake. The Underground water can be heated by magma. The hot water moves through cracks below Earths surface. Hot water can hold more dissolved particles than cold water. The hot, salty solution has chemical reactions with the rocks around it. The water picks up more dissolved particles. As it flows through open spaces in rocks, the water deposits solid minerals. When a mineral fills cracks in rocks, the deposits are called veins. Figure 3.20 shows a white quartz vein. When the minerals are deposited in open spaces, large crystals grow. These rocks are called geodes. Figure 3.20 shows a geode that was formed when amethyst crystals grew in an open space in a rock. 
 Question: to come out of a solution as a solid


Output: precipitate