Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: Phosphorylation of cytoplasmic polyadenylation element binding protein (CPEB) regulates protein synthesis in hippocampal dendrites. CPEB binds the 3' untranslated region (UTR) of cytoplasmic mRNAs and, when phosphorylated, initiates mRNA polyadenylation and translation. We report that, of the protein kinases activated in the hippocampus during synaptic plasticity, calcium/calmodulin-dependent protein kinase II (CaMKII) robustly phosphorylated the regulatory site (threonine 171) in CPEB in vitro. In postsynaptic density fractions or hippocampal neurons, CPEB phosphorylation increased when CaMKII was activated. These increases in CPEB phosphorylation were attenuated by a specific peptide inhibitor of CaMKII and by the general CaM-kinase inhibitor KN-93. Inhibitors of protein phosphatase 1 increased basal CPEB phosphorylation in neurons; this was also attenuated by a CaM-kinase inhibitor. To determine whether CaM-kinase activity regulates CPEB-dependent mRNA translation, hippocampal neurons were transfected with luciferase fused to a 3' UTR containing CPE-binding elements. Depolarization of neurons stimulated synthesis of luciferase; this was abrogated by inhibitors of protein synthesis, mRNA polyadenylation, and CaMKII. These results demonstrate that CPEB phosphorylation and translation are regulated by CaMKII activity and provide a possible mechanism for how dendritic protein synthesis in the hippocampus may be stimulated during synaptic plasticity.

Output: Which kinase is inhibited by the small molecule KN-93?


Input: Consider Input: Brigadier Sir Iltyd Nicholl Clayton CBE (1886 -- 30 June 1955) was a British Army officer notable for his attachment to the Middle East Office in Cairo during and after World War II and his involvement in the formation of Arab League and formulation of post-war British policy in the Middle East.

Output: Who did Iltyd Nicholl Clayton serve for?


Input: Consider Input: EDGEWOOD-Every morning at Dixie Heights High school,customers pour into a special experiment:the district's first coffee shop run mostly by students with special learning needs. Well before classes start,students and teachers order Lattes,Cappuccinos and Hot Chocolates.Then,during the first period,teachers call in orders on their room phones,and students make deliveries.By closing time at 9:20a.m.,the shop usually sells 90drinks."Whoever made the chi tea,Ms.Schatzman says it was good,"Christy McKinley,a second year student,announced recently,after hanging up with the teacher. The shop is called the Dixie PIT,which stands for Power in Transition.Although some of the students are not disabled,many are,and the PIT helps them prepare for life after high school.They learn not only how to run a coffee shop but also how to deal with their affairs.They keep a timecard and receive paychecks,which they keep in check registers. Special-education teachers Kim Chevalier and Sue Casey introduced the Dixie PIT from a similar program at Kennesaw Mountain High School in Georgia.Not that it was easy.Chevalier's first problem to overcome was product-related.Should schools be selling coffee?What about sugar content?Kenton County Food Service Director Ginger Gray helped.She made sure all the drinks,which use non-fat milk,fell within nutrition guidelines.


Output: The coffee shop is mostly run by    .