TASK DEFINITION: Given a document, generate a short title of the document. The title should convey the main idea/event/topic about which the document is being written. Note that URLs in the text have been replaced with [Link].
PROBLEM: A few years ago he began working with Dr. Jenny Chang  medical director of the Lester and Sue Smith Breast Center at Baylor College of Medicine.
 Chang had performed a number of biopsies on breast cancer patients  both on those whose cancers were confined to the breast and on those whose cancers had metastasized to the brain.
 From those biopsies  Chang said she had identified a number of genetic pathways ways in which gene mutations affected the ability of the cancer to spread unique to patients who developed metastatic breast cancer.
 "But I had a lot of trouble with the data and trying to translate it into clinical practice " she said. She couldn't find her way out from beneath the avalanche of data.
 So she turned to Wong.
 Using his mathematical modeling  Wong sifted through Chang's data and the large databases of genome and clinical trial data. Out of that  he identified several candidate drugs to impair the genetic pathways that helped the cancer spread.
Chang's data and the large databases of genome and clinical trial data. Out of that  he identified several candidate drugs to impair the genetic pathways that helped the cancer spread.
 One of them  a drug named sunitinib  which treats a kidney cancer called renal cell carcinoma  emerged as the best bet. Chang then tested the drug in mice  and the study showed it prevented breast cancer from spreading to the brain.
 She has already begun a Phase II clinical trial of the drug  enrolling nine patients with metastatic breast cancer  and she is looking for more.
 "The drug is very well-tolerated by patients  and so far the trial is going very well " Chang said.
 But by using an existing drug  Chang and Wong could skip the lengthy Phase I  during which a drug is checked for safety. If Chang's tests go well  sunitinib could be on the market within a few years for metastatic breast cancer.

SOLUTION: IN OLD DRUGS RESEARCHER LOOKS FOR NEW TREATMENTS

PROBLEM: Brandon Judd  president of the labor union  said  Agent Rogelio Martinez  died Sunday of blunt force trauma to the head.
Federal authorities have not yet said how  Martinez  was killed.
Authorities have been searching for witnesses and potential suspects after  Martinez  was killed and a fellow agent was seriously injured. Officials with U.S. Customs and Border Protection and the Border Patrol said in a statement that the pair were âresponding to activityâ near Interstate 10 in Van Horn  Tex.  when they were harmed. The other agent called for help  and other agents provided medical care and took them to a hospital.
Following news that an agent had been killed  President Trump appeared to connect  Martinez âs death to border security and plugged his plans for a border wall on Twitter on Sunday night.
Sen. Ted Cruz (R-Tex.) said on Twitter  without any further explanation  that  Martinez  and the other agent were âattackedâ and he also linked the incident to security on the border with Mexico.
Agent Rogelio Martinez  your service and sacrifice will never be forgotten. Our hearts go out to your family. pic.twitter.com/WVuW8C2N8n â USBPChief (@USBPChief) November 20  2017
Isaac Morales  who was stabbed in a bar parking lot in El Paso  was the only agent besides  Martinez  to die in 2017. Three agents died in 2016; two of them in car accidents  one of a heart attack while on bike patrol.

SOLUTION: Slain border agent may have been beaten to death by rocks in âgrisly scene â union leader says

PROBLEM: SAN FRANCISCO (Reuters) - Alphabet Inc âs Waymo  sought at least $1 billion in damages and a public apology from Uber Technologies Inc as conditions for settling  its  high-profile trade secret lawsuit against the ride-services company  sources familiar with the proposal told Reuters.
The Waymo self-driving car unit also asked that an independent monitor be appointed to ensure Uber does not use  Waymo  technology in the future  the sources said.
Uber rejected those terms as non-starters  said the sources  who were not authorized to publicly discuss settlement talks. The precise dollar amount requested by  Waymo  and the exact time the offer was made could not be learned.
 Waymoâs  tough negotiating stance  which has not been previously reported  reflects the company âs  confidence in  its  legal position after months of pretrial victories in a case which may help to determine who emerges in the forefront of the fast-growing field of self-driving cars.
The aggressive settlement demands also suggest that  Waymo  is not in a hurry to resolve the lawsuit  in part because of  its  value as a distraction for Uber leadership  said Elizabeth Rowe  a trade secret expert at the University of Florida Levin College of Law.
 Waymo  recently persuaded a San Francisco federal judge to delay a trial to decide the dispute from October to early December  citing the need to investigate evidence Uber had not disclosed earlier.
Amy Candido  a  Waymo  attorney  declined to comment on any settlement talks  but said the companyâs reasons for suing Uber are âpretty clear.â
â Waymo  had one goal: to stop Uber from using  its  trade secrets â  she  said. âThat remains  its  goal.â
 Waymo  sued Uber in February  claiming that former engineer Anthony Levandowski downloaded more than 14 000 confidential files before leaving to set up a self-driving truck company  called Otto  which Uber acquired soon after.
Uber denied using any of Waymoâs trade secrets.
FILE PHOTO: The  Waymo  logo is displayed during the company's unveil of a self-driving Chrysler Pacifica minivan during the North American International Auto Show in Detroit  Michigan  U.S.  January 8  2017. REUTERS/Brendan McDermid/File Photo
 Waymoâs  lawsuit has been disruptive for Uber. U.S. District Judge William Alsup granted  Waymoâs  request for a pretrial injunction in May  which prohibited Levandowski from working on Lidar  a key sensor technology for self-driving cars that is the crux of the current litigation.
Uber later fired Levandowski  regarded as a visionary in autonomous technology  after he refused to return Waymo documents at the heart of the case. Levandowski has asserted his constitutional right against self-incrimination and declined to answer questions from  Waymo  lawyers.
Benchmark cited  Waymo âs allegations of trade secret theft in separate litigation aimed at forcing Kalanick off Uberâs board. A Delaware judge put that lawsuit on hold and sent it to private arbitration.
On Sunday Oct. 1  the day before Kalanick was scheduled to give a deposition in the Waymo case  Kalanickâs lawyers called  Waymo  and asked to postpone the deposition  lawyers for both companies said in court last week.
Kalanickâs lawyers said he was in the middle of a fight to appoint new board members and was therefore too busy   Waymo  attorneys said in court.  Waymo  refused the request  forcing Kalanick to attend the deposition.

SOLUTION:
Exclusive: Alphabet's Waymo demanded $1 billion in settlement talks with Uber