In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
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Question: Paragraph: The plaque assay has long served as the "gold standard" to measure virus infectivity and test antiviral drugs, but the assay is labor-intensive, lacks sensitivity, uses excessive reagents, and is hard to automate. Recent modification of the assay to exploit flow-enhanced virus spread with quantitative imaging has increased its sensitivity. Here we performed flow-enhanced infection assays in microscale channels, employing passive fluid pumping to inoculate cell monolayers with virus and drive infection spread. Our test of an antiviral drug (5-fluorouracil) against vesicular stomatitis virus infections of BHK cell monolayers yielded a two-fold improvement in sensitivity, relative to the standard assay based on plaque counting. The reduction in scale, simplified fluid handling, imagebased quantification, and higher assay sensitivity will enable infection measurements for high-throughput drug screening, sero-conversion testing, and patient-specific diagnosis of viral infections. 
 Title: Infection on a chip: a microscale platform for simple and sensitive cell-based virus assays

Answer: True


Question: Paragraph: Children are more vulnerable to the risks of air pollution, including susceptibility to acquiring chronic diseases in their developing lungs. Despite these, there are no specific masks designed for and tested in children that are available to protect our young from the common particulate air pollutants today. We evaluated safety, fit and comfort of a specially designed paediatric N95 mask with an optional micro ventilator (micro fan, MF) in healthy children aged 7-14 years, in a randomized, two-period crossover design. The subjects' cardiorespiratory physiological measurements were assessed in different states of physical activity under different interventions (mask without and with MF). A total of 106 subjects were recruited between July-August 2016. The use of the mask without MF increased the End-Tidal CO 2 (etco 2 ) and fractional concentration of inspired co 2 (fico 2 ) at rest and on mild exertion, as expected. The use of the mask with MF brought FICO 2 levels comparably closer to baseline levels without the mask for both activities. The mask, with or without the MF, was found to be well fitting, comfortable and safe for use in children at rest and on mild exertion. The N95 mask tested offers a promising start for more studies in the paediatric population. Air pollution, such as haze or smog, is an evolving and increasingly significant problem around the world. A wide range of hazards of chronic air pollution in children include nocturnal cough, asthma, poor performance in neurobehavioral function, negative impact in cognitive development and harmful effects on brain development 1-5 . In particular, children represent a vulnerable segment of any population. They carry more risks of long term exposure to pollution over the course of their lives and are susceptible to acquiring chronic diseases in their developing lungs 6-11 . Use of masks and respirators can offer protection against air pollutants. However, the commercially available disposable particulate respirators, typically certified for surgical (which may only offer some barrier against larger particles) and occupational use, are mainly designed for and studied in adults. The test standards are specified according to adult breathing conditions and fit. There are to date, no masks designed for and evaluated in children. Several studies have investigated the effectiveness, safety, fit and comfort of different types of masks 12-15 . However these studies were done only in adult populations. Even alternatives such as cloth masks have been tested only in adult populations 16 . In another study, the facemasks for paediatric use (FPU, the masks that are not specifically designed for paediatric use but are the existing mask that may be used for children during emergency situation like that of airborne disease outbreaks) were tested mainly to evaluate the leakage associated with donning the FPU 17 . This study did show superiority of FPU in comparison to surgical masks in certain aspects, however, the study was not performed in children. One study was performed in children to evaluate the redesigned open system face mask. However, the objective of this study was to evaluate the mask for monitoring P ETCO2 during sedation in clinical practice and the children in this study donned the mask only for 30 sec. 18 . These and other similar studies merely point to the fact that there are no masks that are specifically designed and tested in children such that they can be prescribed for paediatric use in the setting of daily routine activities. In our study, the N95 masks were specifically designed for use in children and they were evaluated in children under conditions of routine daily activities. They are the first to be paired with a micro ventilator (micro fan, MF), designed to reduce the accumulation of exhaled carbon dioxide (CO 2 ), heat and humidity in the dead space of 
 Title: A randomised clinical trial to evaluate the safety, fit, comfort of a novel N95 mask in children

Answer: False


Question: Paragraph: Recent studies point to the prevalence of the evolutionary phenomenon of drastic structural transformation of protein domains while continuing to preserve their basic biochemical function. These transformations span a wide spectrum, including simple domains incorporated into larger structural scaffolds, changes in the structural core, major active site shifts, topological rewiring and extensive structural transmogrifications. Proteins from biological conflict systems, such as toxinantitoxin, restriction-modification, CRISPR/Cas, polymorphic toxin and secondary metabolism systems commonly display such transformations. These include endoDNases, metalindependent RNases, deaminases, ADP ribosyltransferases, immunity proteins, kinases and E1like enzymes. In eukaryotes such transformations are seen in domains involved in chromatinrelated peptide recognition and protein/DNA-modification. Intense selective pressures from "armrace"-like situations in conflict and macromolecular modification systems could favor drastic structural divergence while preserving function. Drastic structural transformation of protein domains while retaining their basic biochemical function is a notable phenomenon in protein evolution. These transformations span a wide spectrum of structural changes including complex modifications of domain structure. Domains displaying these transformations are most commonly observed in systems involved in biological conflicts, eukaryotic chromatin-related protein/DNA modification and peptide recognition. These systems show "arm-race"-like situations that could favor drastic structural divergence while preserving function Zhang et al. 
 Title: Resilience of biochemical activity in protein domains in the face of structural divergence

Answer:
True