Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

[Q]: Context: NADPH oxidase (Nox) family enzymes are one of the main sources of cellular reactive oxygen species (ROS), which have been shown to function as second messenger molecules. To date, seven members of this family have been reported, including Nox1-5 and Duox1 and -2. With the exception of Nox2, the regulation of the Nox enzymes is still poorly understood. Nox1 is highly expressed in the colon, and it requires two cytosolic regulators, NoxO1 and NoxA1, as well as the binding of Rac1 GTPase, for its activity. In this study, we investigate the role of the tyrosine kinase c-Src in the regulation of ROS formation by Nox1. We show that c-Src induces Nox1-mediated ROS generation in the HT29 human colon carcinoma cell line through a Rac-dependent mechanism. Treatment of HT29 cells with the Src inhibitor PP2, expression of a kinase-inactive form of c-Src, and c-Src depletion by small interfering RNA (siRNA) reduce both ROS generation and the levels of active Rac1. This is associated with decreased Src-mediated phosphorylation and activation of the Rac1-guanine nucleotide exchange factor Vav2. Consistent with this, Vav2 siRNA that specifically reduces endogenous Vav2 protein is able to dramatically decrease Nox1-dependent ROS generation and abolish c-Src-induced Nox1 activity. Together, these results establish c-Src as an important regulator of Nox1 activity, and they may provide insight into the mechanisms of tumor formation in colon cancers. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
[A]: nadph oxidase 1


[Q]: Context: In 1509, Diogo Lopes de Sequeira was sent to Malacca by the king of Portugal with four ships in order to establish contact with the Sultanate of Malacca. Initially, Sequeira was well received by the Sultan Mahmud Syah . Soon however, the Muslim community convinced Mahmud Syah that the Portuguese should be eliminated. Several men were captured and killed, but the ships escaped. Albuquerque first departed from India for Malacca in April 1511, with 1,200 men and 17 to 18 ships. Albuquerque's objective was to sever Islamic trade and Venetian trade on the same occasion.A first attack by the Portuguese failed on 25 July 1511. Albuquerque's captains spoke against another attempt, but he struck again, succeeding in capturing Malacca in August, despite strong resistance and the presence of artillery on the Malaccan side. In celebration, Tristao da Cunha was sent to Pope Leo X in Rome with rich presents including the elephant that the pope named Hanno. 
 Question: Which man succeeded in capturing Malacca, Diogo Lopes de Sequeira or Albuquerque?
[A]: albuquerque


[Q]: Context: Coal, a solid fossil fuel formed from the partially decomposed remains of ancient forests, is burned primarily to produce electricity. Coal use is undergoing enormous growth as the availability of oil and natural gas decreases and cost increases. This increase in coal use is happening particularly in developing nations, such as China, where coal is cheap and plentiful. Coal is black or brownish-black. The most common form of coal is bituminous, a sedimentary rock that contains impurities such as sulfur (Figure 1.1). Anthracite coal has been metamorphosed and is nearly all carbon. For this reason, anthracite coal burns more cleanly than bituminous coal. Coal forms from dead plants that settled at the bottom of ancient swamps. Lush coal swamps were common in the tropics during the Carboniferous period, which took place more than 300 million years ago (Figure 1.2). The climate was warmer then. Mud and other dead plants buried the organic material in the swamp, and burial kept oxygen away. When plants are buried without oxygen, the organic material can be preserved or fossilized. Sand and clay settling on top of the decaying plants squeezed out the water and other substances. Millions of years later, what remains is a carbon- containing rock that we know as coal. Around the world, coal is the largest source of energy for electricity. The United States is rich in coal (Figure 1.3). California once had a number of small coal mines, but the state no longer produces coal. To turn coal into electricity, the rock is crushed into powder, which is then burned in a furnace that has a boiler. Like other fuels, coal releases its energy as heat when it burns. Heat from the burning coal boils the water in the boiler to make steam. The steam spins turbines, which turn generators to create electricity. In this way, the energy stored in the coal is converted to useful energy like electricity. For coal to be used as an energy source, it must first be mined. Coal mining occurs at the surface or underground by methods that are described in the the chapter Materials of Earths Crust (Figure 1.4). Mining, especially underground The location of the continents during the Carboniferous period. Notice that quite a lot of land area is in the region of the tropics. mining, can be dangerous. In April 2010, 29 miners were killed at a West Virginia coal mine when gas that had accumulated in the mine tunnels exploded and started a fire. Coal mining exposes minerals and rocks from underground to air and water at the surface. Many of these minerals contain the element sulfur, which mixes with air and water to make sulfuric acid, a highly corrosive chemical. If the sulfuric acid gets into streams, it can kill fish, plants, and animals that live in or near the water. Click image to the left or use the URL below. URL: 
 Question: the solid form of hydrocarbon is __________________.
[A]:
coal