Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
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Question: A neuroprotective and neuroregenerative treatment attempt with pyridoxine and pyridostigmine was initiated.

Answer: non-adverse drug event


Question: The skin lesions disappeared almost completely within three months.

Answer: non-adverse drug event


Question: Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss.

Answer:
adverse drug event