In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: In disorders related to substance use, what is physical dependence? 
 Options:  <1> In a physical process of short duration. <2> In an intense sense of dissatisfaction for not being able to consume the substances. <3> In the action of consuming drugs producing a state of intoxication with psychoactive effect. <4> In a series of physical and psychic changes that take place after the administration of a substance. <5> In a state of physical adaptation manifested by intense physical disturbances when the administration of the drug is interrupted.
5

Question: The eudismic index is a parameter with pharmacological interest that expresses the relationship between: 
 Options:  <1> Two diastereomer drugs. <2> Two bioisostero drugs. <3> Two enantiomers <4> A drug and a prodrug, structural analog. <5> Two structural modifications, one hydrophilic and one lipophilic, of a certain drug.
3

Question: Which of the following statements is correct regarding the epidemiology of mood disorders ?: 
 Options:  <1> Bipolar disorders account for 25-30% of all mood disorders. <2> The average duration of a depressive episode is usually about 2-3 months. <3> The percentage of relapses of depression throughout life is estimated at 75%. <4> The risk of suicide in depressive disorder is greater than bipolar disorder. <5> 50% or more of the history of bipolar disorder is found in the families of patients with depression.

3