Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

Question: Does pI3K and Bcl-2 inhibition prime glioblastoma cells to apoptosis through downregulation of Mcl-1 and Phospho-BAD?
Answer: Combination therapy with ABT-263 and GDC-0941 has novel therapeutic potential by specifically targeting aberrantly active, deregulated pathways in GBM, overcoming endogenous resistance to apoptosis.
yes

Question: Does acute ethanol always affect delay discounting in rats selected to prefer or avoid ethanol?
Answer: Our data indicate that in these lines of animals, alcohol preference or avoidance has no impact on delay discounting following acute ethanol exposure. It is possible that other genetic models or lines may be differentially affected by alcohol and exhibit qualitatively and quantitatively different responses in delay discounting tasks.
no

Question: Does dydrogesterone reverse the cardiovascular benefits of percutaneous estradiol?
Answer: Both HRT groups showed a reduction in their Framingham score. In contrast to data from other HRT investigations on cardiovascular risk, these formulations proved to be safe, even in the first year of use.

no