In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

[EX Q]: Question: In a determination of the activity of an enzyme, the depletion of the substrate: 
 Options:  <1> It is essential for most trials. <2> It may give falsely low results in sera with high enzymatic activity. <3> It occurs when the reagent is finished. <4> It occurs due to a defect in the spectrophotometer. <5> It can lead to falsely elevated results in sera with high enzymatic activity.
[EX A]: 2

[EX Q]: Question: Exposure to androgens in a sensitive or critical period, at the beginning of development, causes masculinization of the sexual and behavioral organs. This effect has received the name of: 
 Options:  <1> Motivational effect <2> Effect of pheromones. <3> Activating effect. <4> Organizer effect. <5> Biological effect
[EX A]: 4

[EX Q]: Question: Vinblastine and vincristine are: 
 Options:  <1> Indolemonoterpenic alkaloids, dimeric with antiarrhythmic activity. <2> Alkaloids derived from phenylalanine, monomeric with arrhythmic activity. <3> Indolemonoterpenic alkaloids, dimeric with antitumor activity. <4> Indolemonoterpenic, monomeric alkaloids with antitumor activity. <5> Alkaloids derived from phenylalanine, dimeric and with antitumor activity.
[EX A]:
3