Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

[EX Q]: Context: Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, demonstrated efficacy and safety in moderate-to-severe plaque psoriasis when administered via subcutaneous injection. Self-administration by pre-filled syringe (PFS) can offer patients clinical benefits of a drug, with increased convenience. To assess efficacy, safety and usability of secukinumab administration via PFS in subjects with moderate-to-severe plaque psoriasis. Subjects in this phase 3 trial were randomized 1:1:1 to secukinumab 300 or 150mg or matching placebo. Results to week 12 are presented here. Each treatment was delivered using a PFS once weekly to week 4, and again at week 8. Co-primary endpoints were secukinumab superiority over placebo for week 12 PASI 75 (75% reduction in Psoriasis Area and Severity Index) and IGA mod 2011 (2011 modified Investigator's Global Assessment) 0/1 response rates. Secondary endpoints included PFS usability, determined by observer rating of successful, hazard-free self-injection and subject rating of acceptability by the Self-Injection Assessment Questionnaire (SIAQ). Co-primary endpoints were met, with demonstration of superiority for each secukinumab dose vs. placebo at week 12 (PASI 75: 759%, 695% and 0% for secukinumab 300mg, 150mg and placebo; IGA mod 2011 0/1: 690%, 525% and 0%, respectively; P<00001 for all comparisons vs. placebo). PFS usability was high: 100% of subjects successfully self-administered treatment at week 1, and subjects reported high SIAQ-assessed acceptability of the PFS throughout the trial. No new/unexpected safety signals were observed. Secukinumab administration by PFS was effective, with an acceptable safety profile and high usability. The PFS provides a reliable, convenient form of secukinumab administration in subjects with moderate-to-severe plaque psoriasis. 
 Question: Which molecule is targeted by a monoclonal antibody Secukinumab?
[EX A]: interleukin-17a

[EX Q]: Context: The film Calvary is a parable of the betrayal of the Irish people by the Irish Catholic Church.Context for the story: The Irish Catholic Church which was a pillar of, and defined Ireland's soul has been revealed to have consciously and methodically covered up institutional atrocities perpetrated by themselves.Set in rural Ireland, the film begins in a confessional where Father James Lavelle (Brendan Gleeson) is taking confession. The voice on the other side speaks, "I was seven the first time I tasted semen". "Certainly a startling opening line", Father James replies. The voice asks if he's being ironic. Father James takes a more serious tone. The voice tells him that he was molested both orally and anally by a priest when he was seven and he bled a lot. Father James asks if he would like to report the priest. The voice says that the priest died a long time ago and that it didn't matter. "Killing a bad priest isn't a big deal, but if you kill a good priest, people take notice". The voice says he's going to kill Father James in seven days on the beach.James lives a very simple life. He sleeps in a small room with a bed and his only two possessions are his crucifix and his dog. He takes walks on the beach and interacts with the town people. On the beach, he sees his altar server is drawing a landscape. In it there are two figures. James asks who they are and the boy says he doesn't know, but he has been having a lot of dreams about ghosts lately.After mass, Father James is speaking with Father Leary (David Wilmot) who is gossiping about the townsfolk, sharing information he's heard in confession and making racially inappropriate comments about Simon (Isaach De Bankole) the only black man in the town. Father James doesn't say a word about the threat on his life.James' daughter Fiona (Kelly Reilly) comes to town to lay low after a botched suicide attempt. The townsfolk didn't know it was possible for a Catholic priest to have a daughter. James explains that he became a priest after his wife died. The locals in the pub try to flirt with Fiona, but she has no interest. James does not drink. Its not because he doesn't like alcohol. Its because he likes it too much.Later in the day, James visits with Veronica Brennan (Orla ORourke) who was wearing sunglasses during mass to cover up her black eye. She says her husband did it. So James goes to meet her husband, the local butcher Jack Brennan (Chris O'Dowd) and confronts him. Jack is surprised, but good natured about the whole thing. He dismisses his wife by saying she's probably bi-polar. He says it wasn't him, but it might have been her boyfriend Simon. James questions the infidelity, but Jack explains that it works for them. They each do their own thing. James meets with Simon, who takes offense to the charge and passively threatens James and tells him to mind his own business.James spends time with an elderly man known only as The Writer (M. Emmet Walsh) who asks for a Walther PPK, James Bonds favorite gun and the gun Hitler used to kill himself. The Writer explains that he doesn't want to get old and feeble. He'd rather just take his own life when the time is right.James meets with the local Bishop and tells him about the threat during the confession. He also reveals that he knows who the man is and believes the threat is real. The Bishop says that because the man didn't ask for repentance and there was the threat of a law being broken, James would not violate and church law in speaking with the police.James goes to speak with his friend Inspector Stanton (Gary Lydon), who seems to be spending some time with a male prostitute named Leo (Owen Sharpe). Leo keeps making lewd advances on James and offers to have sex with him in his vestments because he knows that's what priests like. Eventually Leo leaves and 
 Question: Who has a lot of anger and rage built up?
[EX A]: james

[EX Q]: Context: The scene opens with Ellen (Sharon Stone) riding across the prairie toward a town, when an idiot digging multiple holes looking for his gold, shoots at her. She falls off her horse and knocks him out as he checks to see if she is dead. After chaining him to his wagon, she continues into town. A large, single elimination gun fighting tournament is about to begin and she is looking for revenge on the man ( Herod/Gene Hackman) who killed her father. She arrives at the bar/hotel. Ace Hanlon shows off his deck of cards with an ace for every man he has killed. Soon, the saloon comes to life as Scars who just got out of jail, comes back to settle a score. He makes a move on Ellen, and she tells him to take a bath. Scars gets angry and kicks the blind boy's peddling wagon, as he was talking to Ellen. Later at the drafting of the tournament, the saloon owner is to sign up 16 gunfighters. Among them are The Kid (Leonardo DiCaprio), Sgt. Cantrell (Kieth David), Cort, the marksman and odds on favorite (Russell Crowe) though he was signed up against his will. Cort was an outlaw who became a preacher and built a mission. Since he was one of Herod's partners in crime, Herod now wants Cort dead. Also in the contest is Ace Hanlon ( Lance Herrickson), A Swedish Champ. and of course Herod. Anyone can challenge anyone, and each fighter must accept the first challenge. Ellen is challenged by the idiot who was digging for his lost gold. But up first was the Kid and he quickly shot the Swede and the winner is the last standing.The Swede was shot twice and then threw his gun down. Also winning, were Stg. Cantrell, Scars, and Eugene the scumbag. Herod has challenged Ace(because he thinks Ace was hired to kill him) and one of Herod's men challenged Cort. After Rusty, another of Herod's men has beaten Cort up as he was chained to a fountain in the middle of the village. Herod has Cort released so that he can go to the Kid's gun store. Herod gives Cort the cheapest gun in the place. The Kid also has told everyone that Herod was his father. Herod denies that and rubs it in the Kid's face. Then Cort went out to a fight that he refused to be in. But when the clock stuck, only one bullet was fired. Herod's man fell to the ground. Many claimed to be the fastest gun in town, like the Kid, Herod, and Ace, but all knew that Cort was the fastest. Next, Ace is bragging and doing gun tricks. It is time for he and Herod to face each other. Herod proves that Ace has been lying about all of his kills. The clock strikes and Herod blows Ace's right thumb off. Then he shoots Ace's left hand. Then after mocking Ace some more, Herod's shoots him in the chest. Then Ellen wins her first fight with Cort's help. The next day, Herod invites Stg. Cantrel to his home. He tells the Sgt, that he knows that he was the hired hand and not Ace. The Sgt. does not tell him much and the challenge has been issued. Later, Herod changes the rules and now all fights are to the death. Herod takes down Cantrell, and then scolds the crowd for hiring him. Meantime, Eugene the scum bag is heard upstairs molesting a girl. He comes downstairs and brags about it. Ellen attacks him from behind and the two scream at each other until the challenge is made. though it is pouring outside, The two come out firing and Eugene gets his manhood shot off. The rules have changed and the winner is the last alive. Ellen couldn't finish him off, so she returned to the bar. Eugene comes in and shoots her glass. Then Ellen empties her gun into him.Though Herod tells the Kid to quit, that he has proven his point, the Kid stays in and takes 
 Question: The lady's father was strung up by whose men?
[EX A]:
herod