Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

[EX Q]: Context: What did the arrival of the Internet and 24 hours news mean for British newspapers? At first, this looked like the end of printed newspapers. The national newspapers were worried that they would lose all the readers, so most of them decided to create an online version . But they still had a problem. How to make money? There was simply too much news and too much information freely available "out there". But was it accurate ( )? Whose opinions should we trust? A survey for a "good newspaper", and most of those said.they believe more of what they read in paid-for newspapers. Here was something newspapers understood--here was what they could offer: news plus comment and opinion. And the Internet now offered new opportunities. A newspaper was just that: news printed on paper. But the Internet now offered newspapers different places to print, and in different media. Many newspapers now have podcasts and video too. This may explain why the readership of newspaper online in the UK is very different from people who read printed newspapers. The most popular newspaper in the UK is The Sun, The "mid-market" audience mainly reads The Daily Mail. Online, it's a different story. The most popular is The Mail. And the next popular site is TheGuardian. In fact many of these browsers are not from the UK. The Mail and Guardian are among the most read newspapers in the USA. The Guardian, may become the largest English language paper on the web; a website with a newspaper attached! 
 Question: The largest English language paper on the Internet may be .
[EX A]: the guardian

[EX Q]: Context: Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy. We enrolled 457 patients who had active rheumatoid arthritis despite long-term methotrexate therapy in a 6-month, double-blind, placebo-controlled trial. The primary outcome was the American College of Rheumatology (ACR) 20 response (which indicates at least a 20% reduction in the number of both tender and swollen joints and improvement in at least three of five other criteria) at month 6. R788, at a dose of 100 mg twice daily and at a dose of 150 mg once daily, was significantly superior to placebo at month 6 (ACR 20 response rates of 67% and 57%, respectively, vs. 35%; P<0.001 for the comparison of both doses with placebo). It was also significantly superior with respect to ACR 50, which indicates at least a 50% improvement (43% and 32% vs. 19%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.007 for the comparison of the 150-mg dose with placebo) and ACR 70 (28% and 14% vs. 10%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.34 for the comparison of the 150-mg dose with placebo). A clinically significant effect was noted by the end of the first week of treatment. Adverse effects included diarrhea (in 19% of subjects taking the 100-mg dose of R788 vs. 3% of those taking placebo), upper respiratory infections (14% vs. 7%), and neutropenia (6% vs. 1%). R788 was associated with an increase in systolic blood pressure of approximately 3 mm Hg between baseline and month 1, as compared with a decrease of 2 mm Hg with placebo; 23% of the patients taking R788 vs. 7% of the patients receiving placebo required the initiation of or a change in antihypertensive therapy. In this phase 2 study, a Syk inhibitor reduced disease activity in patients with rheumatoid arthritis; adverse events included diarrhea, hypertension, and neutropenia. Additional studies will be needed to further assess the safety and efficacy of Syk-inhibition therapy in patients with rheumatoid arthritis. (Funded by Rigel; ClinicalTrials.gov number, NCT00665925.) 
 Question: Which enzyme is inhibited by a drug fostamatinib?
[EX A]: spleen tyrosine kinase

[EX Q]: Context: After an inquest held in a nearby hotel, Florence Maybrick was charged with his murder and stood trial at St George's Hall, Liverpool, before Justice James Fitzjames Stephen, where she was convicted and sentenced to death. 
 Question: Which crime Florence Maybrick is considered to have commited?
[EX A]:
murder