Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

[Q]: To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.
[A]: adverse drug event


[Q]: Phenobarbital hepatotoxicity in an 8-month-old infant.
[A]: adverse drug event


[Q]: This review provides an evidence and experience-based approach to the preventive treatment of migraine.
[A]:
non-adverse drug event