TASK DEFINITION: Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.
PROBLEM: Paragraph: The release makes no mention of the cost of the drug in question, Tenofovir. A web search found that the cost for a month’s supply of the antiviral drug averages just over $1,000. For some patients, that cost may be prohibitive. The cost is an issue of particular concern for developing countries, but it is also true that the price may be much lower for them than in the United States. Many pharmaceutical companies offer their drugs at steeply discounted rates in poorer countries to expand access to life-saving medicines. The release clearly says that 68 percent of women receiving the drug reduced their viral load while only 2 percent of the women in the control group had that success. It also says that the transmission of hepatitis B from mother to newborn dropped from 18 percent to 5 percent, an important clinical outcome. The release includes a discussion of harms. It states that “tenofovir was well tolerated; only one participant treated with tenofovir voluntarily withdrew from the study due to nausea.”  It also says that researchers “found no significant differences between the tenofovir-treated group and the control group with regard to fetal development and infant growth.”  Lastly, it calls for longer term, observational studies to confirm the safety of fetal exposure to tenofovir treatment. The release provides a good overview of the randomized, placebo-controlled trial which was undertaken to gauge the efficacy of the drug in both reducing the viral load of hepatitis-B-positive mothers and reducing the rate of transmission of the disease from mother to newborn. It offers solid, numerical evidence of both outcomes. It describes the number of patients (200 pregnant women), defined what constituted a “high” viral load, and described the approximate length of treatment. It did omit a mention of whether the trial was blinded. This release does not commit disease mongering. The release notes that the research is funded by Gilead Sciences. It should also have mentioned that a corresponding author disclosed speaking and advising fees from Gilead, according to the published study. The release is comparing the use of an antiviral drug given to pregnant women versus the normal procedure of giving both a vaccine and immune globulin. The release doesn’t mention that tenofovir (marketed as Viread), the drug being tested, is already an FDA approved drug so many readers may not know that it’s available. It was approved by the FDA in 2001 for HIV and in 2008 for chronic hepatitis B. The release just barely implies novelty with this statement which suggests a change in treating infected women who are pregnant: “Based on the findings, the investigators recommend that women be tested for HBV viral load at week 28 of pregnancy. Those with a high viral load should receive tenofovir treatment starting at gestational week 30 until delivery to reduce the risk of transmission to their infants.” While the drug itself isn’t novel, positive outcomes from a controlled trial on pregnant women carrying the virus does seem to introduce a new treatment approach. This release does not use any unjustifiable language. Claim: Antiviral Treatment During Pregnancy Reduces Mother-to-Child Transmission of Hepatitis B

SOLUTION: This news release describes a clinical trial testing whether an antiviral drug given to pregnant women in their third trimester reduces their hepatitis B viral load. The study also examined whether the drug limits the transmission of the virus from mother to baby. The answers to both questions are yes, suggesting a new strategy for dealing with the spread of this disease. The release does a good job describing harms, quantifying benefits and describing the study protocol. Because the cost of hepatitis drugs has been widely debated for the past few years, a mention of the drug’s cost would have made the release stronger. Almost 240 million people are infected with hepatitis B virus and about 780,000 die each year from the disease, according to the World Health Organization. The hepatitis B virus infects the liver and while many recover with treatment, it can become a chronic infection. Babies and young children infected with the virus are more likely to develop chronic hepatitis B. If administering a drug to infected mothers reduces the proportion of newborns getting the disease, it would be a considerable improvement in public health.

PROBLEM: Paragraph: Samoa declared a national emergency last month and mandated that all 200,000 people living on the South Pacific island nation get vaccinated. The government has closed all schools and banned children from public gatherings. In all, 53 people have died in the outbreak since late October, including one adult and two older teenagers. Most of those who have died have been babies and young infants, including 23 children aged less than 1 and 25 children aged between 1 and 4. The government said more than 1,100 people have been admitted to hospitals since the outbreak began and about 180 people remain hospitalized. Among those hospitalized are 19 children who are in critical condition. Samoan authorities believe the virus was first spread by a traveler from New Zealand. New Zealand Prime Minister Jacinda Ardern said Monday that her country was doing everything it could to help curb the epidemic, including sending more than 50 medical professionals and thousands of vaccines to Samoa. Other countries including Britain have also sent teams and supplies. Ardern said the natural curve of infection rates meant that “sometimes things can be worse before they are better.” Figures from the World Health Organization and UNICEF indicate that fewer than 30% of Samoan infants were immunized last year. That low rate was exacerbated by a medical mishap that killed two babies who were administered a vaccine that had been incorrectly mixed, causing wider delays and distrust in the vaccination program. The government said about 33,000 people were vaccinated before last month and since then, another 58,000 people have been vaccinated. The World Health Organization has set a target of wiping out measles from most of the world by next year. It says the disease is entirely preventable thanks to a safe vaccine that has been in use since the 1960s, and that measles deaths worldwide decreased by 84% between 2000 and 2016 to about 90,000 annually thanks to better immunization. Claim: 50 children killed by measles in Samoa as outbreak worsens.

SOLUTION: Samoa’s government said Monday that another five children had died within the past day from a measles outbreak, bringing the death toll from the epidemic to more than 50 as authorities race to vaccinate the entire population.

PROBLEM: Paragraph: Torrential rain caused floods and triggered landslides in western Japan last week, bringing death and destruction to neighborhoods built decades ago near steep mountain slopes. At least 176 people were killed, the government said, with dozens missing in Japan’s worst weather disaster since 1982. In Kumano, a mountainside community in Hiroshima prefecture that was hit by a landslide last week, Ken Kirioka anxiously watched rescuers toiling through mud, sand and smashed houses to find the missing, including his 76-year-old father, Katsuharu. “He is old and has a heart condition. I prepared myself for the worst when I heard about the landslide on Friday night,” he said, pointing at a pile of mud and rubble where he said his father was buried. “He is an old-fashioned father who is hard-headed and does not talk much,” Kirioka said, adding he would stay until his father was found. “It would be too bad for him if a family member were not around”. Rescuers working under a scorching sun combed through heaps of wood and thickly caked mud in a search for bodies, helped by sniffer dogs. In some cases only the foundation of homes remained as they cut through debris with chain saws. With temperatures of 33 degrees Celsius (91 degrees Fahrenheit) or higher in the devastated areas in Okayama and Hiroshima prefectures, attention turned to preventing heat-stroke among rescue workers and in evacuation centers where thousands of people have sought shelter. People sat on thin mats on a gymnasium floor in one center, plastic bags of belongings piled around them and bedding folded off to the side. Portable fans turned slowly as children cried. Abe, who canceled an overseas trip to deal with the disaster, was criticized after a photograph posted on Twitter showed Abe and his defense minister at a party with lawmakers just as the rains intensified. After observing the damage from a helicopter flying over Okayama, one of the hardest-hit areas, Abe visited a crowded evacuation center. He crouched down on the floor to speak with people, many of them elderly, and asked about their health. He clasped one man’s hands as they spoke. Later he told reporters the government would do everything it could to help the survivors. “We’ll cut through all the bureaucracy to secure the goods people need for their lives, to improve life in the evacuation centers - such as air conditioners as the hot days continue - and then secure temporary housing and the other things people need to rebuild their lives,” he said. Abe is up for re-election as party leader in September and has seen his popularity ratings edge back up after taking a hit over a cronyism scandal earlier this year. His government pledged an initial $4 billion toward recovery on Tuesday, and a later special budget if needed. Officials turned to social media to warn of the additional danger of food-borne illnesses, urging people to wash their hands and take other measures against food poisoning. Evacuation orders were issued for 25 households in the city of Fukuyama after cracks were found in a reservoir. Water accumulating behind piles of debris blocking rivers also posed a danger after a swollen river rushed into a Fukuyama residential area on Monday, prompting more evacuation orders. The intensifying heat was expected to trigger thunderstorms on Wednesday, with authorities warning new landslides could be set off on mountainsides saturated with water. Japanese media on Wednesday focused on the timing of evacuation orders issued in the hard-hit Mabi district of Kurashiki city just minutes before a levee broke and water poured into the residential area. A number of the dead in Mabi were found in their homes, suggesting they did not have enough time to flee, media reports said. Claim: Japan PM visits flood disaster zone, promises help as new warnings issued.

SOLUTION:
Prime Minister Shinzo Abe visited flood-stricken parts of Japan on Wednesday as the death toll from the worst weather disaster in 36 years reached 176 and health concerns rose amid scorching heat and the threat of new floods.