instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: Background The aim of this study was to assess multiplex PCR analysis in detecting causative viruses in children with febrile seizures. Methods The study was a retrospective analysis comparing data from a pre-multiplex era (2009) with a period after the introduction of routine respiratory multiplex analysis (2010-2013) in children with febrile seizures. Results We included 200 children with febrile seizures (mean age: 29.5 ± 1.4.months; 104 male) in the study. In 2009, in 10 out of 49 (20 %) children, microbiology testing (bacterial/fungal) was positive compared with a rate of 74 out of 151 (49 %) children during 2010-2013 (p < 0.01). The rate of positive virological studies increased from 10 (20 %) in 2009 to 73 (48.3 %) in the period 2010-2013 (p < 0.01). Multiplex PCR analysis confirmed viral infections in 52 of 73 cases (71.2 %). Conclusion Routine multiplex PCR analysis fosters the detection of respiratory viruses in children with febrile seizure. The precise role of multiplex analysis in the J. 
 Title: Role of multiplex PCR analysis in children with febrile seizures management of these children awaits further clarifi- cation
answer:
True


question:
Paragraph: Previously, fusion of established T cell lines or clones has been claimed to be difficult. We now report our experiences in the fusion of both long term cultures of rat T cell clones and mouse T cell lines to rat W/Fu (C58NT)D. Upon fusion of rat T cell clones the hybrids obtained expressed antigen specificities identical to those of the parent clones. In addition, C58 was used for interspecies hybridisation of murine T cell lines. The specificity of intra-and inter-species hybrids was maintained by subcloning. We conclude that the C58 cell line can be used to generate continuously growing monoclonal T-cell reagents of sufficient stability using both intra-and inter-species hybridisation. 
 Title: CD4 rat X rat and mouse x rat T cell hybridomas produced by fusion of established T cell lines and clones to W/Fu (C58NT)D
answer:
True


question:
Paragraph: Bunyaviruses are significant human pathogens, causing diseases ranging from hemorrhagic 26 fevers to encephalitis. Among these viruses, La Crosse virus (LACV), a member of the California 27 serogroup, circulates in the eastern and midwestern United States. While LACV infection is often 28 asymptomatic, dozens of cases of encephalitis are reported yearly. Unfortunately, no antivirals 29 have been approved to treat LACV infection. Here, we developed a method to rapidly test potential 30 antivirals against LACV infection. From this screen, we identified several potential antiviral 31 molecules, including known antivirals. Additionally, we identified many novel antivirals that 32 exhibited antiviral activity without affecting cellular viability. Valinomycin, a potassium ionophore, 33 was among our top targets. We found that valinomycin exhibited potent anti-LACV activity in 34 multiple cell types in a dose-dependent manner. Valinomycin did not affect particle stability or 35 infectivity, suggesting that it may preclude virus replication by altering cellular potassium ions, a 36 known determinant of LACV entry. We extended these results to other ionophores and found that 37 the antiviral activity of valinomycin extended to other viral families including bunyaviruses (Rift 38 Valley fever virus, Keystone virus), enteroviruses (Coxsackievirus, rhinovirus), flavirivuses (Zika), 39 and coronaviruses (229E and MERS-CoV). In all viral infections, we observed significant 40 reductions in virus titer in valinomycin-treated cells. In sum, we demonstrate the importance of 41 potassium ions to virus infection, suggesting a potential therapeutic target to disrupt virus 42 replication. 43 44 Importance 45 No antivirals are approved for the treatment of bunyavirus infection. The ability to rapidly screen 46 compounds and identify novel antivirals is one means to accelerate drug discovery for viruses 47 with no approved treatments. We used this approach to screen hundreds of compounds against 48 La Crosse virus, an emerging bunyavirus that causes significant disease, including encephalitis. 49 We identified several known and previously unidentified antivirals. We focused on a potassium 50 ionophore, valinomycin, due to its promising in vitro antiviral activity. We demonstrate that 51 valinomycin, as well as a selection of other ionophores, exhibits activity against La Crosse virus 52 as well as several other distantly related bunyaviruses. We finally observe that valinomycin has 53 activity against a wide array of human viral pathogens, suggesting that disrupting potassium ion 54 homeostasis with valinomycin may be a potent host pathway to target to quell virus infection. 
 Title: Novel ionophores active against La Crosse virus identified through rapid 1 antiviral screening 2 3
answer:

False