Given a passage, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.

Ex Input:
Polo-like kinase 1 (PLK1) controls the main cell-cycle checkpoints, suggesting utility of its inhibition for cancer treatment, including of highly proliferative pediatric cancer. This preclinical study explored the selective PLK1 inhibitor volasertib (BI 6727) alone and combined with chemotherapy in pediatric malignancies.', 'Inhibition of proliferation was explored in vitro using dimethylthiazol carboxymethoxyphenyl sulfophenyl tetrazolium (MTS) assay. Mice bearing human xenografts were treated with weekly intravenous injections of volasertib.', 'Volasertib inhibited proliferation in all 40 cell lines tested, with a mean half-maximal growth inhibitory concentration of 313 nmol/l (range: 4-5000 nmol/l). Volasertib was highly active against RMS-1 alveolar rhabdomyosarcoma xenografts, resulting in 100% tumor regression. Activity was associated with complete and prolonged G2/M arrest and subsequent apoptotic cell death. Volasertib showed synergistic activity with vincristine but antagonistic effects with etoposide.

Ex Output:
Does polo-like Kinase Inhibitor Volasertib exhibit Antitumor Activity and Synergy with Vincristine in Pediatric Malignancies?


Ex Input:
While the anticholinergic activity of medications has been linked to cognitive decline, few studies have linked anticholinergic burden with falls in older people. We evaluated the relationship between anticholinergic burden and recurrent and injurious falls among community-dwelling older adults.', 'This case-control study was performed on 428 participants aged ≥65 years, 263 cases with two or more falls or one injurious fall in the preceding 12 months, and 165 controls with no falls in the preceding 12 months. Anticholinergic burden was determined using the anticholinergic cognitive burden (ACB) scale. Upper and lower limb functional abilities were assessed with timed up and go (TUG), functional reach (FR) and grip strength (GS). Logistic regression analysis was employed to calculate the mediation effect of TUG, FR and GS on ACB associated falls.', 'Univariate analysis revealed a significant association between an ACB score of ≥1 with falls (OR, 1.8; 95% CI; 1.1-3.0; p=0.01) and significantly poorer TUG and FR. The association between ACB≥1 and falls was no longer significant after adjustment for either TUG (OR for ACB associated falls, 1.4; 95% CI, 0.88-2.4; p=0.14) or FR (OR for ACB associated falls, 1.4; 95% CI, 0.89-2.4, p=0.12) but remained significant with GS.

Ex Output:
Is anticholinergic burden associated with recurrent and injurious falls in older individuals?


Ex Input:
Studies associate atheroemboli with neurologic complications following cardiac surgery. The International Council of Emboli Management (ICEM) has demonstrated debris is captured when intraaortic filtration is employed during cardiac surgery. Particulate debris has been extracted from over 98% of ICEM patients and fibrous atheroma from 73%. Anastomotic device use may reduce aortic manipulation, minimizing debris. This study compares particulate capture among three patient groups: Cohort 1 (n = 745) patients receiving on-pump CABG-only procedures; Cohort 2 (n = 24) patients receiving off-pump CABG-only procedures with conventional anastomoses; Cohort 3 (n = 10) patients receiving off-pump CABG-only procedures with automatic proximal anastomoses.', 'The intraaortic filter was placed distal to anastomoses, and proximal to the innominate artery. Upon removal, filters were fixed in formalin and shipped to a core lab (Stanford, CA). Demographic, procedural, and outcomes data were collected in the ICEM Registry.', 'Of the 745 patients receiving stopped-heart CABG, complete data on preoperative risk factors was reported for 673 patients. At least 19 patients reported complete data in Cohort 2, and 10 reported in Cohort 3. One adverse outcome, a death, occurred in the 24 off-pump patients reporting (4.2%). Histologic analyses showing the number of filters successfully extracting particles, the number of particles and total particulate surface area per filter, and the ranges are shown in below. Histologic Finding Cohort 1 Cohort 2 Cohort 3 Filters with particles 98% 100% 100% Mean # of particles 8.5 9.6 5.6 Range # of particles 0-76 1-29 2-13 Mean surface area (mm2) 11.8 18.4 6.1 Range surface area (mm2) 0-171 0.5-61 0.2-14

Ex Output:

Does intraaortic filtration capture particulate debris in OPCAB cases using anastomotic devices?