Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

[Q]: Most studies report incidence rates ranging from 1.5 to 3%.
[A]: non-adverse drug event


[Q]: In 2 cats, rebound hyperglycemia was diagnosed on routine serial blood glucose determinations.
[A]: non-adverse drug event


[Q]: However, the toxicity profile of leflunomide in patients with underlying GVHD remains to be defined.
[A]:
non-adverse drug event