Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

Input: Consider Input: Paragraph: Although Pfizer continues to test the drug, called dacomitinib, in another Phase III study, hopes for its success have now largely faded, according to ISI Group analyst Mark Schoenebaum. “We believe consensus expectations (for the drug) will be close to zero given today’s readout” of unsuccessful trial results, Schoenebaum said in a research note. In one of the failed trials, called ARCHER 1009, patients given Pfizer’s once-daily pill did not show improved survival without the cancer worsening, compared with Roche Holding AG’s widely used Tarceva (erlotinib). Tarceva is the current standard of care in patients with mutated forms of a protein called Epidermal Growth Factor Receptor (EGFR). The protein plays a role in normal regulation of cell growth, but when mutated is believed to cause cells to proliferate and thereby help spur various types of cancer. Dacomitinib is designed to block several types of Epidermal Growth Factor receptors, while Tarceva and similar treatments for lung cancer target only one type of receptor. Cowen and Co had forecast annual sales of $500 million by 2020 for dacomitinib, if it were approved for lung cancer. That would make it a moderate-sized product for Pfizer, the largest U.S. drugmaker, which has annual revenue of $50 billion. Schoenebaum said there has been little investor interest in the drug and that Wall Street had expected it to generate annual sales of only $300 million by 2018. The second failed trial, named BR.26, involved patients that previously had failed to benefit from chemotherapy as well as from treatment with an EGFR inhibitor. Overall survival of patients taking the Pfizer drug was not prolonged in the study, compared with patients given a placebo. Pfizer said adverse events seen with dacomitinib were consistent with those seen in smaller earlier studies. In the meantime, Pfizer said dacomitinib is also being tested in a third late-stage trial, called ARCHER 1050, among patients with advanced non-small cell lung cancer who have not received prior treatment. The study will compare dacomitinib with Iressa (gefitinib), an EGFR inhibitor sold by AstraZeneca Plc. Results from that study are expected in 2015. Pfizer shares were little changed in morning trading on the New York Stock Exchange. Claim: Pfizer lung cancer drug fails in two large studies.

Output: Pfizer Inc on Monday said one of its experimental drugs had failed to meet its goals in two late-stage studies among patients who had received prior treatment for advanced non-small cell lung cancer, the most common form of the disease.


Input: Consider Input: Paragraph: On 10 June 2016, the Daily Beast reported that Sen. David Perdue urged attendees of the Faith & Freedom Coalition’s Road to Majority conference to pray for misfortune and death to befall President Barack Obama: At a major event for conservative Christians this morning, a Republican senator joked about praying for President Obama’s “days to be short.” Sen. David Perdue, a freshman senator from Georgia, opened his remarks at the Faith & Freedom Coalition’s Road to Majority conference by encouraging attendees to pray for President Obama. But, he added in a joking tone, they need to pray for him in a very specific way: “We should pray for him like Psalms 109:8 says: Let his days be few, and let another have his office,” the senator said, smiling wryly. The crowd chuckled and he moved on with his address. The rest of that passage, which Perdue did not recite, reads, “May his children be fatherless and his wife a widow. May his children be wandering beggars; may they be driven from their ruined homes.” The psalm is a pointed, lengthy death wish for one of David’s enemies. Video depicted Purdue’s 10 June 2016 remarks:  Psalms 109:8 (alternately named “Song of the Slandered”) was rendered in the manner below in the King James Bible: Hold not thy peace, O God of my praise; For the mouth of the wicked and the mouth of the deceitful are opened against me: they have spoken against me with a lying tongue. They compassed me about also with words of hatred; and fought against me without a cause. For my love they are my adversaries: but I give myself unto prayer. And they have rewarded me evil for good, and hatred for my love. Set thou a wicked man over him: and let Satan stand at his right hand. When he shall be judged, let him be condemned: and let his prayer become sin. Let his days be few; and let another take his office. Let his children be fatherless, and his wife a widow. Let his children be continually vagabonds, and beg: let them seek their bread also out of their desolate places. Let the extortioner catch all that he hath; and let the strangers spoil his labour. Let there be none to extend mercy unto him: neither let there be any to favour his fatherless children. Let his posterity be cut off; and in the generation following let their name be blotted out. Let the iniquity of his fathers be remembered with the LORD; and let not the sin of his mother be blotted out. Let them be before the LORD continually, that he may cut off the memory of them from the earth. As many pointed out, the Senator’s Biblical reference wasn’t a new or even uncommon scripture-based jab at President Obama. A 2009 article reported that the verse was traction across the internet as a veiled threat cloaked in the guise of prayerful intent: There’s a new slogan making its way onto car bumpers and across the Internet. It reads simply: “Pray for Obama: Psalm 109:8” A nice sentiment? Maybe not. The psalm reads, “Let his days be few; and let another take his office.” Presidential criticism through witty slogans is nothing new. Bumper stickers, t-shirts, and hats with “1/20/09” commemorated President Bush’s last day in office. But the verse immediately following the psalm referenced is a bit more ominous: “Let his children be fatherless, and his wife a widow.” The slogan comes at a time of heightened concern about antigovernment anger. Earlier this year, the president’s senior adviser, David Axelrod, said that Tea Parties could lead to something unhealthy. In September, authorities shut down a poll on Facebook asking if President Obama should be killed. Still, that doesn’t push the Psalms citation into the realm of hate speech, says Chris Hansen, a staff attorney with the American Civil Liberties Union (ACLU). That particular piece was published during President Obama’s first term in office. Some argued at the time that the reference to the verse simply expressed a hope that he not be re-elected to a second term: Deborah Lauter, director of civil rights at the Anti-Defamation League agrees that the bumper sticker falls within acceptable political discourse. “The problem is you don’t know if people who are donning that message in a shirt or on a bumper sticker are fully aware of the quote or what follows. Obviously that message makes the ambiguity disappear. If they’re just referring to him being out of office, that’s one thing. If they’re referring to him being dead, that’s so offensive. It’s protected speech, but it’s clearly offensive.” However, that motive ceased to be relevant after Obama’s 2012 re-election. A representative for the Senator provided a terse statement to a Bloomberg reporter about the controversy: David Perdue spokeswoman Caroline Vanvick responds in an email: “He in no way wishes harm towards our president” pic.twitter.com/PPj5jtZv0n — Sahil Kapur (@sahilkapur) June 10, 2016  The statement read: Senator Perdue said we are called to pray for our country, for our leaders, and for our president. He in no way wishes harm towards our president and everyone in the room understood that. However, we should add the media to our prayer list because they are pushing a narrative to create controversy and this is exactly what the American people are tired of. It is true Sen. David Perdue laughed and referenced Psalms 109:8 during a 10 June 2016 conservative Christian event. A representative for the Senator addressed the ensuing controversy, blaming the media for “pushing a narrative” for the outcry. Claim: Sen. David Perdue advised attendees to offer up an ominous prayer aimed at President Obama during the 2016 Faith & Freedom Coalition’s Road to Majority conference.

Output: What's true: Sen. David Perdue referenced Psalms 109:8 at an event; Perdue's representative later denied he wished death on the President. What's false: Sen. Perdue didn't explicitly state attendees at the conference should pray expressly for the President to die.


Input: Consider Input: Paragraph: Israel has seen five deaths and close to 2,400 cases so far. Citizens hoping for a stroll or jog were instructed earlier on Wednesday to stay within 100 metres (110 yards) of their homes for a week under tightened restrictions to curb the contagion. The new restrictions further reduced public transport, required employers to check workers for fever and set sanctions for people who defy rules. Israelis have been instructed to stay home where possible, schools have been shut and many businesses have closed, prompting more than 500,000 lay-offs. “If we do not see an immediate improvement in the trendline there will be no avoiding a full closure,” Netanyahu said in televised remarks. “(The decision) is a matter of a few days (away). And we are making all of the preparations for it.”   The sight of people, out for fresh air, jogging and congregating on city streets has alarmed health authorities. The new 100-metre limit is meant to end such activity. The private sector has had to limit employees at the workplace to 10 people or 30% of the company’s workforce, and most of the public sector has been put on leave. Israelis, though, could still drive themselves to work or to shops for essentials under the new restrictions, and food delivery services were operating. Penalties ranging from fines to a six-month jail term were set for anyone defying the orders. Israel’s central bank on Tuesday projected an economic contraction of 2.5% in 2020 as long as the partial lockdown eases by the end of April. In his remarks, Netanyahu said his caretaker government was setting up an economic plan to help businesses and the self-employed, and that a team was set-up to prepare for the day after the virus ends. The coronavirus crisis comes as Israel is grappling with political deadlock after three inconclusive elections in less than a year. Netanyahu’s centrist political rival, former military chief Benny Gantz, has been tasked with forming a new coalition government. But neither Gantz nor Netanyahu won a stable parliamentary majority in the March 2 election and negotiations to form a unity government comprising both their parties have come to a halt in the past few days. Claim: Israel's Netanyahu says complete lockdown unavoidable unless new infections ebb.


Output: Israeli Prime Minister Benjamin Netanyahu said on Wednesday there would be “no avoiding” a complete lockdown of the country without a decrease in the rate of new coronavirus infections.