Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
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Question: Context: Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia chromosome, which is associated with a balanced translocation involving chromosomes 9 and 22 to produce a fusion gene (bcr-abl) that gives rise to a constitutively activated Abl tyrosine kinase. This kinase led to the discovery of several small-molecule inhibitors, imatinib being the first and most successful of these. Resistance to imatinib results in some patients from Abl kinase point mutations. Overcoming imatinib resistance represents one of the biggest challenges facing clinicians in the modern management of CML. In this review, we discuss the current understanding of CML pathophysiology and mechanisms of imatinib resistance and how advancing this knowledge has led to the design of novel therapies in the area of blastic phase CML and Philadelphia chromosome-positive acute lymphoblastic leukemia with previous imatinib failure. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

Answer: bcr-abl


Question: Context: Young people frequently say that they want to exercise, but they just can't find the time. The solution just might be in-office interval training. Recent studies show that very short but intense exercise rapidly builds and maintains fitness and health, even when the workout is only a few minutes long. Work the stairs You can complete an excellent, effective -- and very brief -- workout in an office stairwell, says Martin Gibala, a professor of kinesiology at McMaster University in Canada and an expert on interval training. For a study that he and his colleagues presented earlier this year, they asked 12 out-of-shape women in their 20s to warm up for two minutes by slowly walking up and down stairs in a campus office building. They completed three of these abbreviated stair workouts per week for six weeks. By the end, their aerobic fitness had improved substantially, the researchers reported, by about as much as if they had been running or cycling each week for hours. Fidget your way to fitness. Parents and teachers may once have urged you to sit still, but wiggling, tapping your toes, standing briefly, and otherwise fidgeting as much as possible at your desk is in fact good for your body. In one recent study, college students showed healthier blood flow in their lower legs if they fidgeted than if they did not. Even better, a 2008 study found that among office workers, those who frequently fidgeted burned as many as 300 calories more each day than those who resolutely stayed still. 
 Question: How many studies are shown in the passage?

Answer: three


Question: Context: Clay gets up from his trailer at the beach and drives to Mr. Jimmy's lush house, where he mows the lawn.Mr. Jimmy has a visit from David, who is concerned about his health. He then goes out to chat with Clay, his new gardener, and invites him to swim in the pool after he is done working. Clay says he needs to do another lawn later.An academic named Edmund Kay comes to visit Mr. Jimmy, and expresses his deep enthusiasm for his films. Jimmy takes him out back to the pool, and recalls his youth in London, and then his movement into movies and on to Hollywood.Mr. Jimmy becomes bored with Kay's questions, and suggests that Kay begin removing clothing in exchange for his answers. Kay begins disrobing to each of Jimmy's tales about homosexuals in Hollywood and making Frankenstein.Jimmy then gets lightheaded and needs Kay's help to get inside and lie down. His maid Hanna scolds him for chasing boys after just returning from the hospital.Jimmy goes to a doctor who explains that he had a stroke which has left his brain somewhat impaired.Jimmy sees Clay working out in the garden and invites him to talk over iced tea in his painting studio. Jimmy tells him he directed the first two Frankenstein movies, and they talk about his paintings. Jimmy tells Clay he has an expressive head and asks him to model for pay; Clay agrees.Clay arrives at Jimmy's house and Hanna asks if he is going to hurt him. Clay is confused, and she withdraws the question. Clay sits down in the studio to model for Jimmy, who asks him to remove his shirt, even though he only plans to draw his face. Jimmy begins to draw, telling Clay of a memory he has about eating fat drippings as a poor child. He explains how different he was from his family, more talented, more intelligent.Clay goes to a bar and boasts that a famous director is drawing him. Betty the bartender, whom Clay has slept with, turns on The Bride of Frankenstein on TV; meanwhile, Jimmy watches at home with Hanna. The others at the bar criticize the film for not being scary. Clay seems to understand the monster's feelings of loneliness.Flashback: Jimmy directs the performers on the set of Bride of Frankenstein.Clay and Betty talk outside the bar, and he gets upset that she does not want to sleep with him again.Clay calls his parents from a payphone but does not want to talk much.Jimmy dreams that Clay is Dr. Frankenstein, replacing his brain and electrifying him.Hanna tells Clay that Jimmy would like him to have lunch. The two talk as she cooks, and Hanna tells him he should be married. Hanna tells Clay that Jimmy commits unspeakable sins of the flesh, buggery. She is surprised that Clay did not know.Jimmy and Clay have a rather fancy lunch. Jimmy tells Clay that he had hoped Bride of Frankenstein would be seen as a comedy. Jimmy asks Clay to pose for an hour after lunch, and he declines. Jimmy explains that he had a "husband" named David, and Clay asks about his homosexuality. They smoke cigars, and Clay agrees to pose.During the sitting, Jimmy talks about how he made the successful Show Boat and then tried to make his WWI masterpiece The Road Back but the studio butchered it. He says he always wanted to go back to movies, but that was the end. He also broke up with David thereafter. Jimmy begins to describe how he used to have many male models, all naked, which upsets Clay so much he gets mad and storms out.Clay goes to Betty's bar but she is not there. He finds another woman and has sex with her in the parking lot.Clay returns to Jimmy's house and says he will sit for him again if he eases up on the locker room talk. Jimmy is curious that Clay has never known any gay men before, not even when he was in the Marines. Jimmy recalls a young soldier from WWI he mentored in the trenches, then becomes quite upset, looking at Clay intensely 
 Question: Who does Whale ask to kill him to relieve him of his suffering?

Answer:
clay