Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: Protein kinases (PKs) and lipid kinases (LKs) are good choices for targets of signal transduction therapy as these enzymes are involved in signaling pathways, and are often related to the pathogenesis of lymphoid malignancies. The attractiveness of PKs and LKs as drug able targets is enhanced by the fact that they are enzymes whose biological activity can be turned off by drugs that block their catalytic site. In the last few years small molecular kinase inhibitors (KIs) have been synthesized and become available for preclinical studies and clinical trials. The first KI, introduced into clinical practice in 1998, was imatinib mesylate, which became the first choice drug in chronic myeloid leukemia. More recently, several KIs have been developed to target the proximal B-cell receptor (BCR) signaling pathway including spleen tyrosine kinase inhibitor (Fostamatinib) and Bruton's tyrosine kinase inhibitors (Ibrutinib, AVL-263). These agents are currently evaluated in early clinical trials in chronic lymphocytic leukemia (CLL) and other diseases. Cyclin-dependent kinase (Cdk) inhibitors, flavopiridol (alvocidib), BMS-387032 (SNS-032), sunitinib and sorafenib are currently under evaluation in clinical trials for relapsed/refractory CLL. Multi-tyrosine kinase inhibitors including vandetanib (ZD6474) bosutinib (SKI-606), TKI258 (CHIR-258), pazopanib (GW786034) and axitinib (AG013736) have been also developed for the treatment of lymphoid malignancies. Phosphatidylinositol 3-kinases (PI3K ) are a family of lipid kinases that mediate signals from cell surface receptors. CAL-101 (GS-1101) is an oral PI3K-specific inhibitor which has shown preclinical and clinical activity against CLL. This article summarizes recent achievements in the mechanism of action, pharmacological properties and clinical activity and toxicity of PK and LK inhibitors in CLL.
[A]: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?


[Q]: The water droplets of fog form from water vapor in the air. Fog disappears when the water droplets change back to water vapor. These changes are examples of changes of state. A change of state occurs whenever matter changes from one state to another. Common states of matter on Earth are solid, liquid, and gas. Matter may change back and forth between any two of these states. Changes of state are physical changes in matter. They are reversible changes that do not change matters chemical makeup or chemical properties. For example, when fog changes to water vapor, it is still water and can change back to liquid water again. Several processes are involved in common changes of state. They include melting, freezing, sublimation, deposition, condensation, and evaporation. The Figure 1.1 shows how matter changes in each of these processes. Q: Which two processes result in matter changing to the solid state? A: The processes are deposition, in which matter changes from a gas to a solid, and freezing, in which matter changes from a liquid to a solid. Suppose that you leave some squares of chocolate candy in the hot sun. A couple of hours later, you notice that the chocolate has turned into a puddle like the one pictured in the Figure 1.2. Q: What happened to the chocolate? A: The chocolate melted. It changed from a solid to a liquid. In order for solid chocolate to melt and change to a liquid, the particles of chocolate must gain energy. The chocolate pictured in the Figure 1.2 gained energy from sunlight. Energy is the ability to cause changes in matter, and it is always involved in changes of state. When matter changes from one state to another, it either absorbs energyas when chocolate meltsor loses energy. For example, if you were to place the melted chocolate in a refrigerator, it would lose energy to the cold air inside the refrigerator. As a result, the liquid chocolate would change to a solid Q: Why is energy always involved in changes of state? A: The energy of particles of matter determines the matters state. Particles of a gas have more energy than particles of a liquid, and particles of a liquid have more energy than particles of a solid. Therefore, in order for matter to change from a solid to a liquid or from a liquid to a gas, particles of matter must absorb energy. In order for matter to change from a gas to a liquid or from a liquid to a solid, particles of matter must lose energy.
[A]: which process does not involve matter in the liquid state?


[Q]: The Anaspidoglanis boutchangai is considered to be of least concern to becoming an endangered species.
[A]:
How endangered does the iucn consider Anaspidoglanis boutchangai?