Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Ex Input:
Hepatotoxicity induced by cyproterone acetate: a report of three cases.

Ex Output:
adverse drug event


Ex Input:
MR appears to be valuable in the detection of abnormalities induced by treatment with high-dose methotrexate.

Ex Output:
non-adverse drug event


Ex Input:
Heparin-associated thrombocytopenia: successful therapy with the heparinoid Org 10172 in a patient showing cross-reaction to LMW heparins.

Ex Output:

adverse drug event