Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

[Q]: PDT was performed twice, but after the second cycle, patient developed choroidal ischemia and the visual outcomes were poor.
[A]: non-adverse drug event


[Q]: These patients were treated by the continuous administration of an estrogen-progestogen combination for 6 months.
[A]: non-adverse drug event


[Q]: There have been many reports of probable lithium-induced organic brain syndromes occurring when serum lithium levels are within or close to the therapeutic range.
[A]:
adverse drug event