You are given a background paragraph that describes one or more causal or qualitative relationships such as a relationship in economics or a scientific law and a story that makes use of the concepts or the relationship described in the provided paragraph. You need to come up with a question about the story that requires an understanding of the relationship described in the background paragraph. The generated question should not be answerable without both the background and story. Write a question about the story that requires a relationship in the background paragraph to answer. Check whether your question requires both the background paragraph and the story to answer. If your question can be answered by only one of these, try to rewrite your question so that it requires both. Note that "flipping" a word in the question can give rise to a new question where the answer will be different from the original question. Often, "flipping" a word gives rise to flipping the direction of the relationship, for example, from "increase" to "decrease."

[EX Q]: Background Paragraph: Currently, millions of individuals with high cholesterol take a similar type of drug, known as a statin. The drug, an inhibitor of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis, decreases blood levels of cholesterol by induce the expression of low density lipoprotein (LDL) receptors in the liver. The increased levels of the LDL-receptors stimulate the catabolism of plasma LDL, removing cholesterol from plasma, which is an important determinant of atherosclerosis. You may know of people who take a statin to help with their cholesterol levels. However, these drugs probably work slightly differently in many of those people. In some, it lowers their cholesterol significantly; in others it may lower it only moderately; and in some, it may have no significant effect at all. (Luckily for those individuals, there are multiple versions of the statins, so different drugs can be tested to find the proper combination for that individual.) Why the difference? Because of the genetic background of all people; the different single nucleotide polymorphisms that make us all different. Pharmacogenomics, a combination of pharmacology and genomics (the study of the genome) that refers to the study of the relationship between pharmaceuticals and genetics, may explain and simplify this problem. 
Story: Two university students studied different types of drugs for their exams. Kate studied statins, while Carol studied anti-depressants.
[EX A]: Which student learned less about an inhibitor of HMG-CoA reductase?

[EX Q]: Background Paragraph: As for the public health or food safety concern, organic foods are intended to be healthy, free of contaminations and free from agents that could cause human diseases. Organic milk is meant to have no chemical residues to consumers, and the restrictions on the use of antibiotics and chemicals in organic food production has the purpose to accomplish this goal. Although dairy cows in both organic and conventional farming practices can be exposed to pathogens, it has been shown that, because antibiotics are not permitted as a preventative measure in organic practices, there are far fewer antibiotic resistant pathogens on organic farms. This dramatically increases the efficacy of antibiotics when/if they are necessary. 
Story: Two farmers sold their produce and milk on a large nearby market. John practiced organic farming and also produced organic milk, while Danny sold non-organic produce and milk.
[EX A]: Which farmer didn't sell milk with no chemical residues?

[EX Q]: Background Paragraph: Huge amounts of chemicals, such as fertilizers and pesticides, are applied to farm fields (see Figure below ). Some of the chemicals are picked up by rainwater. Runoff then carries the chemicals to nearby rivers or lakes. Dissolved fertilizer causes too much growth of water plants and algae. This can lead to dead zones where nothing can live in lakes and at the mouths of rivers. Some of the chemicals can infiltrate into groundwater. The contaminated water comes up in water wells. If people drink the polluted water, they may get sick. 
Story: Lucy and Sarah are two people who each own a lake that they enjoy spending time at. They have to take care of the lake though and make sure everything is healthy so that the lake can continue to thrive and people will want to visit it. Sarah says she heard a secret that if you dump fertilizer into your lake, the fish will grow twice as large. Sarah says she has just started doing it this past week and can't wait to see the results. Lucy is skeptical and waits to see what happens at Sarah's lake.
[EX A]:
Dead zones will be less prevalent in Lucy's lake or Sarah's lake?