Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

Input: Consider Input: Question: Are cXXC4 mRNA levels associated with clinicopathological parameters and survival of myelodysplastic syndrome patients?
Answer: This study demonstrated that the age of patients and levels of CXXC4 mRNA, hemoglobin, and marrow blast associated with survival of MDS patients.

Output: yes


Input: Consider Input: Question: Are clinical and serum-based markers associated with death within 1 year of de novo implant in primary prevention ICD recipients?
Answer: Individuals with more comorbidities and elevation of specific serum biomarkers were at increased risk of all-cause mortality despite being deemed as having a reasonable 1-year life expectancy. A simple risk score composed of readily available clinical data and serum biomarkers may better identify patients at high risk of early mortality and improve patient selection and counseling for primary prevention ICD therapy.

Output: yes


Input: Consider Input: Question: Do montelukast and zafirlukast affect the pharmacokinetics of the CYP2C8 substrate pioglitazone?
Answer: Montelukast and zafirlukast do not increase the plasma concentrations of pioglitazone, indicating that their inhibitory effect on CYP2C8 is negligible in vivo, despite their strong inhibitory effect on CYP2C8 in vitro. The results highlight the importance of in vivo interaction studies and of the incorporation of relevant pharmacokinetic properties of drugs, including plasma protein binding data, to in vitro-in vivo interaction predictions.


Output: no