In this task, you are given a sentence. You are expected to recognize the name of gene or protein. Although there might be several correct answers, you need to write one of them.

[Q]:  Overall , the phenotype observed in XHM - ED patients shows that the putative zinc - finger domain of NEMO has a regulatory function and demonstrates the definite requirement of CD40 - mediated NF - kappaB activation for B cell immunoglobulin class - switching .
[A]: NF - kappaB


[Q]:  Nevertheless , inhibitors of these pathways clearly reduced the TNF - alpha - induced cell growth , indicating that TNF - alpha - proliferative cells produced a growth factor that induced proliferation upon stimulation of the above pathways .
[A]: TNF - alpha


[Q]:  Little is known , however , about the functions of PPAR - gamma in the immune system , especially in T lymphocytes .
[A]:
PPAR - gamma