instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: Telomeres may regulate human disease by at least two independent mechanisms. First, replicative senescence occurs once short telomeres generate DNA-damage signals that produce a barrier to tumor progression. Second, telomere position effects (TPE) could change gene expression at intermediate telomere lengths in cultured human cells. Here we report that telomere length may contribute to the pathogenesis of facioscapulohumeral muscular dystrophy (FSHD). FSHD is a late-onset disease genetically residing only 25-60 kilobases from the end of chromosome 4q. We used a floxable telomerase to generate isogenic clones with different telomere lengths from affected patients and their unaffected siblings. DUX4, the primary candidate for FSHD pathogenesis, is upregulated over ten-fold in FSHD myoblasts and myotubes with short telomeres, and its expression is inversely proportional to telomere length. FSHD may be the first known human disease in which TPE contributes to age-related phenotype. 
 Question: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?
answer:
fshd


question:
Context: Humans use six times as much water today as they did 100 years ago. People living in developed countries use a far greater proportion of the worlds water than people in less developed countries. What do people use all of that water for? Besides drinking and washing, people need water for agriculture, industry, household uses, and recreation (Figure Water use can be consumptive or non-consumptive, depending on whether the water is lost to the ecosystem. Non-consumptive water use includes water that can be recycled and reused. For example, the water that goes down the drain and enters the sewer system is purified and then redistributed for reuse. By recycling water, the overall water consumption is reduced. Consumptive water use takes the water out of the ecosystem. Can you name some examples of consumptive water use? Some of the worlds farmers still farm without irrigation by choosing crops that match the amount of rain that falls in their area. But some years are wet and others are dry. For farmers to avoid years in which they produce little or no food, many of the worlds crops are produced using irrigation. Water used for home, industrial, and agricultural purposes in different regions. Globally more than two-thirds of water is for agriculture. Three popular irrigation methods are: Overhead sprinklers. Trench irrigation: canals carry water from a water source to the fields. Flood irrigation: fields are flooded with water. All of these methods waste water. Between 15% and 36% percent of the water never reaches the crops because it evaporates or leaves the fields as runoff. Water that runs off a field often takes valuable soil with it. A much more efficient way to water crops is drip irrigation (Figure 1.2). With drip irrigation, pipes and tubes deliver small amounts of water directly to the soil at the roots of each plant or tree. The water is not sprayed into the air or over the ground, so nearly all of it goes directly into the soil and plant roots. Why do farmers use wasteful irrigation methods when water-efficient methods are available? Many farmers and farming corporations have not switched to more efficient irrigation methods for two reasons: 1. Drip irrigation and other more efficient irrigation methods are more expensive than sprinklers, trenches, and flooding. 2. In the United States and some other countries, the government pays for much of the cost of the water that is used for agriculture. Because farmers do not pay the full cost of their water use, they do not have any financial incentive to use less water. What ideas can you come up with to encourage farmers to use more efficient irrigation systems? Aquaculture is a different type of agriculture. Aquaculture is farming to raise fish, shellfish, algae, or aquatic plants (Figure 1.3). As the supplies of fish from lakes, rivers, and the oceans dwindle, people are getting more fish from aquaculture. Raising fish increases our food resources and is especially valuable where protein sources are limited. Farmed fish are becoming increasingly common in grocery stores all over the world. Workers at a fish farm harvest fish they will sell to stores. Growing fish in a large scale requires that the fish stocks are healthy and protected from predators. The species raised must be hearty, inexpensive to feed, and able to reproduce in captivity. Wastes must be flushed out to keep animals healthy. Raising shellfish at farms can also be successful. For some species, aquaculture is very successful and environmental harm is minimal. But for other species, aqua- culture can cause problems. Natural landscapes, such as mangroves, which are rich ecosystems and also protect coastlines from storm damage, may be lost to fish farms (Figure 1.4). For fish farmers, keeping costs down may be a problem since coastal land may be expensive and labor costs may be high. Large predatory fish at the 4th or 5th trophic level must eat a lot, so feeding large numbers of these fish is expensive and environmentally costly. Farmed fish are genetically different from wild stocks, and if they escape into the wild they may cause problems for native fish. Because the organisms live so close together 
 Question: water that can be recycled and reused is called ____________water use.
answer:
non-consumptive


question:
Context: It is part of the Icelandair Group and, during the summer of 2015, operated scheduled services to 39 cities in 16 countries on both sides of the Atlantic Ocean out of its hub at Keflavik International Airport. 
 Question: Which airline hub does Icelandair operate out of?
answer:

keflavík international airport