Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: When reporter ANN MITCHELL is laid off by managing editor HENRY CONNELL because of streamlining, she begs to stay on since she's supporting her MOTHER and TWO SISTERS, but it's no use. Angry, she gathers up her belongings but then, as a parting shot, types up a fake letter from "John Doe" stating that he's so downtrodden by the unfairness of things that he intends jumping off the building on Christmas Eve.The paper prints the letter and it causes a sensation. Everyone relates to and wants to help John Doe. Connell, desperate to get hold of the original letter is shocked when Ann tells him there was no letter. Connell, angry, is ready to print a retraction but Ann suggests that they hire a "fake John Doe" to embody the pathos of the letter. She gets her job back along with a lucrative fee and contract.Several desperate MEN line up claming to have written the letter, so Ann and Connell must now pick the one. When handsome JOHN WILLOUGHBY walks in, Ann's clearly smitten. A likeable, quiet baseball player who's fallen on bad times, John's the one who will become "John Doe." Although he seems too honest to lie, Ann believes he's desperate enough. They create a fake letter, put him up at a fancy hotel with bodyguards, making him sign an agreement. Also in tow (much to Connell's chagrin) is THE COLONEL, a confirmed vagabond, distrustful of society, who warns John that he's falling into a trap of privilege.Next come publicity photos, which are directed by Ann to get the correct "angry protest" look. With headlines proclaiming his anger at the unfairness of the world, John becomes an increasing media sensation, courtesy of hyperbolic headlines concocted by Connell. Meanwhile, the GOVERNOR suspects John Doe is a myth but mistakenly feels it was concocted by publisher B. D. NORTON to discredit him. Ann convinces Norton to play it for what it's worth. Norton offers her money to write radio speeches to sell Doe. He also wants her to work directly with him and not Connell.Ann goes to work, typing up a storm but nothing comes to mind. Ann's Mother suggests that she write something upbeat and simple, using the values of Ann's late father as an inspiration. By now, John has begun realizing that his baseball career might not get started again if the John Doe business is revealed as a phony.Nonetheless, John reads his first manufactured upbeat speech, written by Ann to a packed house. Ann coaches him to be sincere, suggesting that she's fallen in love with John Doe. The speech, broadcast on the radio, stirs the people with its "love thy neighbor"-style message. CROWDS love him but John can't get away fast enough. He and the Colonel resort to the boxcars and flee. B. D. Norton, thinking he was great, wants him located.When a DINER WAITER recognizes him, John's hope for a return to normalcy is squelched by sudden CROWDS, eager to meet him. Ann and Norton locate him. John isn't happy about it. When Norton offers him a lecture tour, he refuses it angrily. When the common PEOPLE who have a "John Doe" club talk to him, however, he softens when hearing how he's touched them. Now, John's torn. His itinerant pal, The Colonel, thinks he's been "hooked" and, disgusted, walks out on him.Norton arranges the lecture tour. John speaks in state after state, addressing the many national clubs in his name. Connell tells Norton, however, that he's curious why Norton is spending so much money on the tour. In the meantime, Ann, knowing that John now likes her, feels increasingly like the heel she feels she is. She feels even worse when John relates a tender dream that he had about her and talks to her about how he relates to the lonely, hungry people to whom he's been speaking.Norton gives Ann a fur coat and a gift. He then tells her that he wants John Doe to announce a 
 Question: "John Doe" threatens suicide on what day?
christmas eve

Context: NeXTSTEP (also stylized as NeXTstep, NeXTStep, and NEXTSTEP) is a combination of several parts: a Unix operating system based on the Mach kernel, plus source code from BSD Display PostScript and a proprietary windowing engine the Objective-C language and runtime an object-oriented (OO) application layer, including several ''kits'' development tools for the OO layers NeXTSTEP is notable for having been a preeminent implementation of the latter three items. 
 Question: What is the programming language for NeXTSTEP?
objective-c

Context: The major constituent of senile plaques in Alzheimer's disease is a 42-aa peptide, referred to as beta-amyloid (Abeta). Abeta is generated from a family of differentially spliced, type-1 transmembrane domain (TM)-containing proteins, called APP, by endoproteolytic processing. The major, relatively ubiquitous pathway of APP metabolism in cell culture involves cleavage by alpha-secretase, which cleaves within the Abeta sequence, thus precluding Abeta formation and deposition. An alternate secretory pathway, enriched in neurons and brain, leads to cleavage of APP at the N terminus of the Abeta peptide by beta-secretase, thus generating a cell-associated beta-C-terminal fragment (beta-CTF). A pathogenic mutation at codons 670/671 in APP (APP "Swedish") leads to enhanced cleavage at the beta-secretase scissile bond and increased Abeta formation. An inhibitor of vacuolar ATPases, bafilomycin, selectively inhibits the action of beta-secretase in cell culture, suggesting a requirement for an acidic intracellular compartment for effective beta-secretase cleavage of APP. beta-CTF is cleaved in the TM domain by gamma-secretase(s), generating both Abeta 1-40 (90%) and Abeta 1-42 (10%). Pathogenic mutations in APP at codon 717 (APP "London") lead to an increased proportion of Abeta 1-42 being produced and secreted. Missense mutations in PS-1, localized to chromosome 14, are pathogenic in the majority of familial Alzheimer's pedigrees. These mutations also lead to increased production of Abeta 1-42 over Abeta 1-40. Knockout of PS-1 in transgenic animals leads to significant inhibition of production of both Abeta 1-40 and Abeta 1-42 in primary cultures, indicating that PS-1 expression is important for gamma-secretase cleavages. Peptide aldehyde inhibitors that block Abeta production by inhibiting gamma-secretase cleavage of beta-CTF have been discovered. 
 Question: Which disease the London mutation involved in?

alzheimer's disease