Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Transcription factors of the NFAT (nuclear factor of activated T cells) family are expressed in most immune system cells and in a range of other cell types. Signaling through NFAT is implicated in the regulation of transcription for the immune response and other processes, including differentiation and apoptosis. NFAT normally resides in the cytoplasm, and a key aspect of the NFAT activation pathway is the regulation of its nuclear import by the Ca(2+)/calmodulin-dependent phosphatase calcineurin. In a cell line stably expressing green fluorescent protein (GFP)-NFAT, this import can be triggered by elevation of intracellular calcium and visualized in live cells. Here we show that the inducible nuclear import of GFP-NFAT is efficiently blocked at early stages of herpes simplex virus (HSV) infection. This is a specific effect, since we observed abundant nuclear accumulation of a test viral protein and no impediment to general nuclear localization signal-dependent nuclear import and retention in infected cells. We show that virus binding at the cell surface is not itself sufficient to inhibit the signaling that induces NFAT nuclear translocation. Since the block occurs following infection in the presence of phosphonoacetic acid but not cycloheximide, we infer that the entry of the virion and early gene transcription are required but the effect is independent of DNA replication or late virus gene expression. A consequence of the block to GFP-NFAT import is a reduction in NFAT-dependent transcriptional activation from the interleukin-2 promoter in infected cells. This HSV-mediated repression of the NFAT pathway may constitute an immune evasion strategy or subversion of other NFAT-dependent cellular processes to promote viral replication.
Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)?

German academics believe they have solved the centuries-old mystery of the "Mona Lisa" in Leonardo ad Vinci's famous portrait . Lisa Gherardini, the wife of a wealthy Florentine merchant, Francesco del Giocondo, has long been seen as the most likely model for the sixteenth-century painting. Art historians have wondered whether the smiling woman may actually have been da Vinci's lover or mother, or the artist himself. Now experts at the prefix = st1 /HeidelbergUniversitylibrary say old notes made in a book by its owner in October, 1503, confirm that Lisa del Giocondo was indeed the model for the famous portrait in the world. "All doubts about the identity of the Mona Lisa have been removed by a discovery by Dr. Armin Schlechter," the library said in a statement on Monday. "Until then, only 'scant evidence' from sixteenth-century documents had been available. These had left lots of room for doubt, and many different identities were put forward." The comments compare Leonardo to the ancient Greek artist Apelles, and say he was working on three paintings at that time, one of which was a portrait of Lisa del Giocondo. Art experts say the Heidelbergdiscovery is a break-through, and the earliest mention linking the merchant's wife to the portrait. Before this discovery the earliest link dated from around 1550, and was made by Italian official Giorgio Vasari, the library said, adding that there had been doubts about Vasari's reliability. The Heidelbergnotes were actually discovered over two year's ago in the library by Schlechter, a spokeswoman said. Although the findings were published in the library's catalogue, they were not widely publicized, and received little attention until a German broadcaster decided to do some recording there, she said.
Who discovered the Heidelbergnotes?

The general Chinese history texts on the Ming Dynasty, including the Mingdai Shi and the Mingshi, briefly mention Cao Qin's failed coup of 1461. Cao Qin's coup and the events leading up to it were covered in Gao Dai's Hong you lu of 1573, Jiao Hong's Guochao Xianzheng lu of 1594-1616, the Huang Ming shi gai of 1632 and the Mingshi jishi benmo of 1658. Li Xian also wrote about Cao Jixiang's career in his "Cao Jixiang zhi bian," featured in the Huang Ming mingchen jingji lu that was edited by Huang Xun in 1551.

Which was written first, Gao Dai's Hong you lu or the Huang Ming shi gai?