Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
Freshwater below Earths surface is called groundwater. The water infiltrates, or seeps down into, the ground from the surface. How does this happen? And where does the water go? Water infiltrates the ground because soil and rock are porous. Between the grains are pores, or tiny holes. Since water can move through this rock it is permeable. Eventually, the water reaches a layer of rock that is not porous and so is impermeable. Water stops moving downward when it reaches this layer of rock. Look at the diagram in Figure 13.11. It shows two layers of porous rock. The top layer is not saturated; it is not full of water. The next layer is saturated. The water in this layer has nowhere else to go. It cannot seep any deeper into the ground because the rock below it is impermeable. The top of the saturated rock layer in Figure 13.11 is called the water table. The water table isnt like a real table. It doesnt remain firmly in one place. Instead, it rises or falls, depending on how much water seeps down from the surface. The water table is higher when there is a lot of rain and lower when the weather is dry. An underground layer of rock that is saturated with groundwater is called an aquifer. A diagram of an aquifer is shown in Figure 13.12. Aquifers are generally found in porous rock, such as sandstone. Water infiltrates the aquifer from the surface. The water that enters the aquifer is called recharge. Most land areas have aquifers beneath them. Many aquifers are used by people for freshwater. The closer to the surface an aquifer is, the easier it is to get the water. However, an aquifer close to the surface is also more likely to become polluted. Pollutants can seep down through porous rock in recharge water. An aquifer that is used by people may not be recharged as quickly as its water is removed. The water table may lower and the aquifer may even run dry. If this happens, the ground above the aquifer may sink. This is likely to damage any homes or other structures built above the aquifer. One of the biggest aquifers in the world is the Ogallala aquifer. As you can see from Figure 13.13, this aquifer lies beneath parts of eight U.S. states. It covers a total area of 451,000 square kilometers (174,000 square miles). In some places, it is less than a meter deep. In other places, it is hundreds of meters deep. The Ogallala aquifer is an important source of freshwater in the American Midwest. This is a major farming area, and much of the water is used to irrigate crops. The water in this aquifer is being used up ten times faster than it is recharged. If this continues, what might happen to the Ogallala aquifer? The top of an aquifer may be high enough in some places to meet the surface of the ground. This often happens on a slope. The water flows out of the ground and creates a spring. A spring may be just a tiny trickle, or it may be a big gush of water. One of the largest springs in the world is Big Spring in Missouri, seen in Figure 13.14. Water flowing out of the ground at a spring may flow downhill and enter a stream. Thats what happens to the water that flows out of Big Spring in Missouri. If the water from a spring cant flow downhill, it may spread out to form a pond or lake instead. Lake George in New York State, which is pictured in Figure 13.15, is a spring-fed lake. The lake basin was carved by a glacier. Some springs have water that contains minerals. Groundwater dissolves minerals out of the rock as it seeps through the pores. The water in some springs is hot because it is heated by hot magma. Many hot springs are also mineral springs. Thats because hot water can dissolve more minerals than cold water. Grand Prismatic Spring, shown in Figure 13.16, is a hot mineral spring. Dissolved minerals give its water a bright blue color. The edge of the spring is

Ex Output:
top of an underground rock layer that is saturated with water


Ex Input:
Imatinib mesylate is a new drug that can inhibit the tyrosine kinase activity of Bcr-Abl, the receptors for platelet-derived growth factor receptor(PDGF) and stem cell factor, or c-kit. Chronic myeloid leukemia (CML) is distinguished by the presence of a reciprocal translocation between chromosomes 9 and 22 that results in a shortened chromosome 22, termed the Philadelphia(Ph) chromosome. As a result of the translocation, a fusion gene called the Bcr-Abl gene is created from two normal cellular genes, encoding a chimeric Bcr-Abl protein with a deregulated tyrosine kinase activity. The expression of Bcr-Abl tyrosine kinase has been shown to be necessary and sufficient for the transformed phenotype of CML cells. Imatinib can block the kinase activity of Bcr-Abl, thus inhibiting the proliferation of Ph-positive progenitors, and has shown activity against all phases of CML, though responses are most substantial and durable in patients in the chronic phase. An international phase III study which compared the efficacy of imatinib with that of interferon alpha combined with low-dose cytarabine in newly diagnosed chronic-phase CML showed the rate of major cytogenetic response at 24 months was 90%, including 82% of complete cytogenetic response. These results indicated that imatinib was superior to interferon-containing treatment as a first-line therapy. More than 10,000 patients worldwide, including those in Japan, have been treated with imatinib in clinical trials, and a lot of information has been accumulated on the use of this drug. The aim of this article is to review the use of this drug and the practical management of patients with chronic myeloid leukemia.

Ex Output:
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Ex Input:
The 1980 film Magnificent 72 and the 2011 film 72 Heroes focus on the uprising. Events of the uprising open the 2011 film 1911.

Ex Output:

Which film cam out first, in 1980 Magnificent 72 or 2011 72 Heroes?