Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
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Question: This is a rare complication of bypass surgery and may be a cause of recurrent angina postoperatively due to coronary artery steal.

Answer: non-adverse drug event


Question: Neuroimaging shows bilateral subcortical and cortical edema with prominent posterior distribution.

Answer: non-adverse drug event


Question: CASE: We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.

Answer:
adverse drug event