In this task, you are given a sentence and question which can be answered using the sentence. Your task is to answer the question using the information from the sentence. The answer to the question is unique and it is a continuous text span from the sentence.
--------
Question: Sentence: When BrdU is integrated into DNA , it is supposed that the bromine deforms the minor groove so that Hoechst dyes can not reach their optimal binding site . 
 Question: why does something deform something?

Answer: so that Hoechst dyes can not reach their optimal binding site


Question: Sentence: After graduation , Ciprian went on to study acting at the Bucharest Conservatory , where he was coached by Constantin Nottara . 
 Question: where was someone coached?

Answer: at the Bucharest Conservatory


Question: Sentence: Millais , absorbed by his painting and did not notice and Siddal did not complain . 
 Question: who did n't  complain  about something?

Answer:
Siddal