In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Example Input: Paragraph: This article investigates an epidemic spreading among several locations through a transportation system, with a hub connecting these locations. Public transportation is not only a bridge through which infections travel from one location to another but also a place where infections occur since individuals are typically in close proximity to each other due to the limited space in these systems. A mathematical model is constructed to study the spread of an infectious disease through such systems. A variant of the next generation method is proposed and used to provide upper and lower bounds of the basic reproduction number for the model. Our investigation indicates that increasing transportation efficiency, and improving sanitation and ventilation of the public transportation system decrease the chance of an outbreak occurring. Moreover, discouraging unnecessary travel during an epidemic also decreases the chance of an outbreak. However, reducing travel by infectives while allowing susceptibles to travel may not be enough to avoid an outbreak. 
 Title: Spatial spread of an epidemic through public transportation systems with a hub
Example Output: True

Example Input: Paragraph: CD13/Aminopeptidase N (CD13) is known to play an important role in tumour cell invasion. We examined whether basic fibroblast growth factor (bFGF) is involved in the regulation of CD13 expression in human melanoma cells. 1F6 human melanoma cells were stably transfected with constructs encoding either the 18 kDa (18kD) or all (ALL) bFGF isoform proteins. We observed highly increased CD13 mRNA and protein expression in the 1F6 clones regardless of the overexpression of either the 18kD or all isoform proteins. Neutral aminopeptidase activity was increased five-fold and could be inhibited by bestatin and the CD13-neutralising antibody WM15. The enhanced invasion through Matrigel, but not migration in a wound assay, was efficiently abrogated by both bestatin and WM15. Upregulation of CD13 expression was the result of increased epithelial and myeloid promoter activity up to 4.5fold in 1F6-18kD and 1F6-ALL clones. Interestingly, in a panel of human melanoma cell lines, a significant correlation (r 2 ¼ 0.883, Po0.05) between bFGF and CD13 mRNA and protein expression was detected. High bFGF and CD13 expression were clearly related with an aggressive phenotype. Taken together, our data indicate that high bFGF expression upregulates CD13 expression in human melanoma cells by activating both the myeloid and the epithelial CD13 promoter. In addition, we show that high bFGF and CD13 expression results in enhanced invasive capacity and metastatic behaviour of human melanoma cells. 
 Title: CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells
Example Output: False

Example Input: Paragraph: The rapid identification of highly specific and potent drug candidates continues to be a substantial challenge with traditional pharmaceutical approaches. Moreover, many targets have proven to be intractable to traditional small-molecule and protein approaches. Therapeutics based on RNA interference (RNAi) offer a powerful method for rapidly identifying specific and potent inhibitors of disease targets from all molecular classes. Numerous proof-of-concept studies in animal models of human disease demonstrate the broad potential application of RNAi therapeutics. The major challenge for successful drug development is identifying delivery strategies that can be translated to the clinic. With advances in this area and the commencement of multiple clinical trials with RNAi therapeutic candidates, a transformation in modern medicine may soon be realized. The RNase Dicer initiates RNAi by cleaving double-stranded RNA substrates into small fragments of about 21-25 nucleotides in length (Fig. 1) . These siRNA duplexes are incorporated into a protein complex called the RNA-induced silencing complex (RISC; Fig. 1 ). Biochemical analysis identified Argonaute 2 (Ago2) as the protein in RISC responsible for mRNA cleavage 3 , and the crystal structure of RNA-bound Ago2 has been reported, revealing key interactions 4 . Before RISC activation, the sense (nonguide) strand of the siRNA duplex is cleaved by Ago2, in the same manner as it cleaves mRNA substrates 5,6 . Preventing sense-strand cleavage by chemical modification can reduce siRNA potency in vitro; however, experimental context is important, as siRNAs with highly stabilized (uncleavable) sense strands can be highly active. Small-molecule pharmaceutical drugs, almost without exception, meet the 'Lipinski Rules' , criteria including high lipophilicity and molecular weight of not more than 500. In sharp contrast, siRNAs naturally lack these drug-like properties owing to their large size (two turns of a nucleic acid double helix), nearly 40 anionic charges due to the phosphodiester backbone, and high molecular weight (over 13 kDa). In aqueous solution, with their sugar-phosphate backbone exposed to water, siRNAs are extremely hydrophilic and heavily hydrated. Furthermore, siRNAs are unstable in serum as a result of degradation by serum nucleases, contributing to their short half-lives in vivo 7 . Although the molecular weight of siRNAs cannot be reduced, these molecules can be made more 'drug-like' through judicious use of chemical modification to the sugars, backbone or bases of the oligoribonucleotides. Chemically modified siRNA duplexes have been evaluated in cellbased assays and in animal models. The modifications discussed are 
 Title: RNAi therapeutics: a potential new class of pharmaceutical drugs R E V I E W
Example Output:
True