Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: The All-Russia People's Front (Russian: ), known by its Russian initialism ONF, is a movement in Russia started in 2011 by then-Prime Minister of Russia Vladimir Putin to provide United Russia with ''new ideas, new suggestions and new faces''.

Output: Who led All-Russia People's Front?


Input: Consider Input: Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder resulting in the growth of a variety of tumours, and is inherited in an autosomal dominant pattern. Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours that commonly harbour oncogenic mutations in KIT or PDGFRA and are thought to arise from the interstitial cells of Cajal (ICC; the pacemaker cells of the gut). To characterise two patients with NF1 and GISTs. Two patients were genotyped for germline mutations in NF1. GISTs from both patients were genotyped for somatic mutations in KIT and PDGFRA. Loss of heterozygosity (LOH) of NF1 in one GIST was assessed by genotyping seven microsatellite markers spanning 2.39 Mb of the NF1 locus in the tumour and in genomic DNA. The known germline mutation in NF1 was confirmed in GIST DNA by sequencing. The copy number of the mutated NF1 allele was determined by multiplex ligand-dependent probe amplification. GISTs from both patients were of wild type for mutations in KIT and PDGFRA. In the GIST with adequate DNA, all seven markers were informative and showed LOH at the NF1 locus; sequencing of NF1 from that GIST showed no wild-type sequence, suggesting that it was lost in the tumour. Multiplex ligand-dependent probe amplification analysis showed that two copies of all NF1 exons were present. This is the first evidence of mitotic recombination resulting in a reduction to homozygosity of a germline NF1 mutation in an NF1-associated GIST. We hypothesise that the LOH of NF1 and lack of KIT and PDGFRA mutations are evidence of an alternative pathogenesis in NF1-associated GISTs.

Output: Which is the gene mutated in type 1 neurofibromatosis?


Input: Consider Input: Like water and carbon, nitrogen is also repeatedly recycled through the biosphere. This process is called the nitrogen cycle. Nitrogen is one of the most common elements in living organisms. It is important for creating both proteins and nucleic acids, like DNA. The air that we breathe is mostly nitrogen gas (N2 ), but, unfortunately, animals and plants cannot use the nitrogen when it is a gas. In fact, plants often die from a lack of nitrogen even through they are surrounded by plenty of nitrogen gas. Nitrogen gas (N2 ) has two nitrogen atoms connected by a very strong triple bond. Most plants and animals cannot use the nitrogen in nitrogen gas because they cannot break that triple bond. In order for plants to make use of nitrogen, it must be transformed into molecules they can use. This can be accomplished several different ways ( Figure 1.1). Lightning: When lightening strikes, nitrogen gas is transformed into nitrate (NO3 ) that plants can use. Nitrogen fixation: Special nitrogen-fixing bacteria can also transform nitrogen gas into useful forms. These bacteria live in the roots of plants in the pea family. They turn the nitrogen gas into ammonium (NH4 + ) (a process called ammonification). In water environments, bacteria in the water can also fix nitrogen gas into ammonium. Ammonium can be used by aquatic plants as a source of nitrogen. Nitrogen also is released to the environment by decaying organisms or decaying wastes. These wastes release nitrogen in the form of ammonium. Ammonium in the soil can be turned into nitrate by a two-step process completed by two different types of bacteria. In the form of nitrate, nitrogen can be used by plants through the process of assimilation. It is then passed along to animals when they eat the plants. Turning nitrate back into nitrogen gas, the process of denitrification, happens through the work of denitrifying bacteria. These bacteria often live in swamps and lakes. They take in the nitrate and release it back to the atmosphere as nitrogen gas. Just like the carbon cycle, human activities impact the nitrogen cycle. These human activities include the burning of fossil fuels, which release nitrogen oxide gasses into the atmosphere. Releasing nitrogen oxide back into the atmosphere leads to problems like acid rain.


Output: the initial step of producing a nitrogen containing compound from nitrogen in the soil is