Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Imatinib was the first BCR-ABL tyrosine kinase inhibitor to become clinically available. In this study, we retrospectively evaluated the long-term efficacy of low-dose imatinib (final maintenance dose <300mg per day) due to intolerance, in comparison to optimal-dose imatinib (300mg per day) in patients with Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase. The Kaplan-Meier estimates of the median time to complete cytogenetic response, major molecular response, and complete molecular response were longer for 31 patients receiving low-dose imatinib (360, 1360, and 1420days, respectively) than 74 patients receiving optimal-dose imatinib (170, 420, and 720days, respectively). However, the differences in response shrank over time and progression-free survival were comparable between the two groups. These findings suggest that long-term treatment with low-dose imatinib is an acceptable alternative for patients with intolerance to the optimal dose.

Answer: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Question: Do you know of anyone who uses the truth to deceive ? When someone tells you something that is true, but leaves out important information that should be included, he can give you a false picture. For example, some might say, "I just won a hundred dollars on the lottery . It was great. I took that dollar ticket back to the store and turned it in for one hundred dollars!" This guy's a winner, right? Maybe, maybe not. We then discover that he bought $200 worth of tickets, and only one was a winner. He's really a big loser! www. .com He didn't say anything that was false, but he left out important information on purpose. That's called a half-truth. Half-truths are not technically lies, but they are just as dishonest. Some politicians often use this trick. Let's say that during Governor Smith's last term, her state lost one million jobs and gained three million jobs. Then she seeked another term. One of her opponents said, "During Governor Smith's term, the state lost one million jobs!" That's true. However, an honest statement would have been, "During Governor Smith's term, the state had a net gain of two million jobs." Advertisers will sometimes use half-truths. It's against the law to make false statements so they try to mislead you with the truth. An advertisement might say, "Nine out of ten doctors advised their patients to take Yucky Pills to cure toothache." It fails to mention that they only asked ten doctors and nine of them work for the Yucky Company. This kind of deception happens too often. Lies are lies, and sometimes the truth can lie as well, which is a sad fact of life.

Answer: How much did the lottery winner lose?


Question: 1303 Luthera (1928 FP) is an outer main-belt asteroid discovered on March 16, 1928, by Friedrich Karl Arnold Schwassmann at Hamburg-Bergedorf Observatory.

Answer:
The inventor of 1303 Luthera was whom?