instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: NADPH oxidase (Nox) family enzymes are one of the main sources of cellular reactive oxygen species (ROS), which have been shown to function as second messenger molecules. To date, seven members of this family have been reported, including Nox1-5 and Duox1 and -2. With the exception of Nox2, the regulation of the Nox enzymes is still poorly understood. Nox1 is highly expressed in the colon, and it requires two cytosolic regulators, NoxO1 and NoxA1, as well as the binding of Rac1 GTPase, for its activity. In this study, we investigate the role of the tyrosine kinase c-Src in the regulation of ROS formation by Nox1. We show that c-Src induces Nox1-mediated ROS generation in the HT29 human colon carcinoma cell line through a Rac-dependent mechanism. Treatment of HT29 cells with the Src inhibitor PP2, expression of a kinase-inactive form of c-Src, and c-Src depletion by small interfering RNA (siRNA) reduce both ROS generation and the levels of active Rac1. This is associated with decreased Src-mediated phosphorylation and activation of the Rac1-guanine nucleotide exchange factor Vav2. Consistent with this, Vav2 siRNA that specifically reduces endogenous Vav2 protein is able to dramatically decrease Nox1-dependent ROS generation and abolish c-Src-induced Nox1 activity. Together, these results establish c-Src as an important regulator of Nox1 activity, and they may provide insight into the mechanisms of tumor formation in colon cancers. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
answer:
nadph oxidase 1


question:
Context: The male reproductive organs include the penis, testes, and epididymis ( Figure 1.1). The figure also shows other parts of the male reproductive system. The penis is a cylinder-shaped organ. It contains the urethra. The urethra is a tube that carries urine out of the body. The urethra also carries sperm out of the body. This drawing shows the organs of the male reproductive system. It shows the organs from the side. Find each organ in the drawing as you read about it in the text. The two testes (singular, testis) are egg-shaped organs. They produce sperm and secrete testosterone. The testes are found inside of the scrotum. The scrotum is a sac that hangs down outside the body. The scrotum also contains the epididymis. The testes, being in the scrotum outside the body, allow the temperature of the sperm to be maintained at a few degrees lower than body temperature. This is necessary for the stability of these reproductive cells. The epididymis is a tube that is about six meters (20 feet) long in adults. It is tightly coiled, so it fits inside the scrotum. It rests on top of the testes. The epididymis is where sperm grow larger and mature. The epididymis also stores sperm until they leave the body. Other parts of the male reproductive system include the vas deferens and the prostate gland. Both of these structures are pictured below ( Figure 1.1). The vas deferens is a tube that carries sperm from the epididymis to the urethra. The prostate gland secretes a fluid that mixes with sperm to help form semen. The prostate gland is located beneath the bladder. Semen is a "milky" liquid that carries sperm through the urethra and out of the body. In addition to sperm cells, semen contains sugars (fructose) which provide energy to the sperm cells, and enzymes and other substances which help the sperm survive. 
 Question: what organ or gland sits on top of the testes?
answer:
the epididymis


question:
Context: The Jack Sport was a French automobile manufactured from 1925 until 1930. 
 Question: What year was the end of Jack Sport?
answer:

1930