Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Facioscapulohumeral muscular dystrophy (FSHD) is a dominant disease linked to contraction of an array of tandem 3.3-kb repeats (D4Z4) at 4q35. Within each repeat unit is a gene, DUX4, that can encode a protein containing two homeodomains. A DUX4 transcript derived from the last repeat unit in a contracted array is associated with pathogenesis but it is unclear how. Using exon-based microarrays, the expression profiles of myogenic precursor cells were determined. Both undifferentiated myoblasts and myoblasts differentiated to myotubes derived from FSHD patients and controls were studied after immunocytochemical verification of the quality of the cultures. To further our understanding of FSHD and normal myogenesis, the expression profiles obtained were compared to those of 19 non-muscle cell types analyzed by identical methods. Many of the ~17,000 examined genes were differentially expressed (>2-fold, p<0.01) in control myoblasts or myotubes vs. non-muscle cells (2185 and 3006, respectively) or in FSHD vs. control myoblasts or myotubes (295 and 797, respectively). Surprisingly, despite the morphologically normal differentiation of FSHD myoblasts to myotubes, most of the disease-related dysregulation was seen as dampening of normal myogenesis-specific expression changes, including in genes for muscle structure, mitochondrial function, stress responses, and signal transduction. Other classes of genes, including those encoding extracellular matrix or pro-inflammatory proteins, were upregulated in FSHD myogenic cells independent of an inverse myogenesis association. Importantly, the disease-linked DUX4 RNA isoform was detected by RT-PCR in FSHD myoblast and myotube preparations only at extremely low levels. Unique insights into myogenesis-specific gene expression were also obtained. For example, all four Argonaute genes involved in RNA-silencing were significantly upregulated during normal (but not FSHD) myogenesis relative to non-muscle cell types. DUX4's pathogenic effect in FSHD may occur transiently at or before the stage of myoblast formation to establish a cascade of gene dysregulation. This contrasts with the current emphasis on toxic effects of experimentally upregulated DUX4 expression at the myoblast or myotube stages. Our model could explain why DUX4's inappropriate expression was barely detectable in myoblasts and myotubes but nonetheless linked to FSHD.

Answer: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?


Question: Researchers from France and Italy discovered that Canadian parents are less strict with their children than mothers and fathers in France and Italy. "Our most important finding was the difference between Canadians and the others," said Professor Michel Claes,the lead author of the study."Canadians focus on independence and negotiation.On the other hand,Italians,for example,exercise more control.We found Canadians seem to focus on negotiation in case of a conflict." Claes said Canada,France and Italy were selected for the study because they share important cultural and social factors."We chose FrenchCanadians because they share the same language as France,and originally came from France and share certain values.Italy was included because it was considered to have similar,strong and important family values," he explained. The researchers examined the emotional ties between parents and their children by questioning 1,256 students aged 11 to 19 years old. Canadian students reported less control and more free actions,according to the study.Italian parents were stricter and French parents were somewhere in the middle. Claes explains that the differences lie in education in Canada,France and Italy. "North America has its own educational values,which promote individualization.Tolerance and comprehension are encouraged.Italy,on the other hand,promotes respect of authority,control,and the need for permission." he said. Children from all three countries described their mothers as warm and communicative.Italian and Canadian children had similar feelings about their fathers,and reported high levels of emotional ties.But French fathers were generally thought by their children to be more distant and cold. "We were surprised by this," Claes admitted."It seems as though the relationships between French mothers and their children were becoming closer over time,while fathers maintain a form of distance and coldness,which is more of a source of conflict in France than in the other countries."

Answer: According to Michel Claes,what mainly leads to the differences in parentchildren relationships among Canada,France and Italy?


Question: Brilliant but irresponsible scientist Tony Nelson (James Congdon) develops an electronic amplifier that he hopes will allow any object to achieve a 4th dimensional (4D) state. While in this state that object can pass freely through any other object. However, Tony failed to pay attention to the overload, which sparks an electrical fire that burns down his lab, resulting in the university terminating his contract. Now unemployed, Tony seeks out his brother Scott (Robert Lansing), a researcher working on a material called cargonite that is so dense as to be impenetrable, to help him with his experiment. Scott is underpaid and unappreciated at his job but does not have the drive to challenge his employer, Mr. Carson, for greater recognition, especially since Scott has been the driving force behind the development of cargonite (named after Carson, showing he is grabbing much of the credit for Scott's work). When his girlfriend (Lee Meriwether) falls for Tony, an enraged Scott steals Tony's experiment and starts playing with it, eventually sending himself into a 4D state. When demonstrating this to Tony, Scott does not turn on the amplifier power yet successfully passes his hand through a block of steel, meaning Scott can now enter the 4D state via his own will. Tony is amazed but warns Scott not to reveal this until he can further test it for any side effects. While in the 4D state, Scott can pass through any solid object. The downside is that, while in that state, Scott ages at a greatly accelerated rate. He soon learns how to survive however, when an aged Scott visits the company doctor, who, while examining him, suddenly drops dead. Simply by touching others, Scott can drain their lifeforce, thereby rejuvenating himself. One night, Scott experiments with his abilities by being able to shoplift a piece of fruit from a grocery store window. Scott also notices a diamond necklace on display in a jewelry store window, but decides against stealing it. However, when Scott sees the bank, his face breaks into a sly grin. The police are wondering about a bizarre crime, over $50,000 was stolen from the bank with no forced entry nor video footage of wrongdoing, and a $20 bill was found protruding from a piece of tempered steel. Tony realizes Scott is abusing his power and tries to convince the police of the experiment. Scott starts using his new found power to acquire all the things he felt he was denied: money, recognition, power, and women. Scott then confronts Mr. Carson, revealing the experiment, then taking his revenge "for the life drained from me" by literally draining Carson's life force to rejuvenate his. After killing Carson, Scott then proceeds to a sleazy bar. He gets some toughs to back down, and his new found bravado combined with his ill-gotten money to impress a bar girl. Later in a car, when they kiss, Scott does not kill her, but drains her life force to the point where she becomes old, frightening her into running away. The police have to find a way to stop a man who is practically unstoppable. Looking old now, Tony returns to the nuclear lab where they are also unable to stop him. The girlfriend catches him when he is solid and shoots and wounds Scott after they kiss (which does not drain her life force). Bleeding and feeling betrayed, Scott maniacally proclaims his invincibility and defiantly phases his body through a wall embedded with supposedly impenetrable cargonite, his hand, slowly and with seeming difficulty, phasing lastly through the wall. "The End" then appears on the screen. A moment later, a question mark appears turning the closing phrase into an interrogative statement leaving into question whether Scott has died or survived.

Answer:
What can Scott pass his hand through?