Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: Chronic myeloid leukemia (CML) is characterized by the Philadelphia translocation that fuses BCR sequences from chromosome 22 upstream of the ABL gene on chromosome 9. The chimerical Bcr-Abl protein expressed by CML cells has constitutive tyrosine kinase activity, which is essential for the pathogenesis of the disease. Imatinib, an ATP-competitive selective inhibitor of Bcr-Abl, has unprecedented efficacy for the treatment of CML. Most patients with early stage disease achieve durable complete hematological and complete cytogenetic remissions, with minimal toxicity. In contrast, responses are less stable in patients with advanced CML. This review highlights the pathogenesis of CML, its clinical features, and the development of imatinib as a specific molecularly targeted therapy. Aspects of disease monitoring and side effects are covered as well as resistance to imatinib and strategies to overcome resistance, such as alternative signal transduction inhibitors and drug combinations. Perspectives for further development are also discussed.

Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Input: Consider Input: Coming off their divisional road win over the Dolphins, the Jets flew to Ralph Wilson Stadium for a Week 4 AFC East duel with the throwback-clad Buffalo Bills. New York scored in the first quarter as running back LaDainian Tomlinson got a 1-yard touchdown run. The Jets added onto their lead in the second quarter with a 19-yard field goal from kicker Nick Folk, followed by quarterback Mark Sanchez completing a 41-yard touchdown pass to wide receiver Braylon Edwards. The Bills closed out the half with quarterback Ryan Fitzpatrick finding tight end David Martin on a 4-yard touchdown pass. New York pulled away in the third quarter as tight end Dustin Keller caught a 3-yard touchdown pass from wide receiver/quarterback Brad Smith, followed by his 2-yard touchdown reception thrown by Sanchez. Afterwards, Tomlinson's 26-yard touchdown run effectively secured the victory. Buffalo closed out the game in the fourth quarter as Fitzpatrick threw a touchdown pass to wide receiver Steve Johnson.

Output: Which player scored multiple touchdowns?


Input: Consider Input: Although soil scientists recognize thousands of types of soil - each with its own specific characteristics and name - lets consider just three soil types. This will help you to understand some of the basic ideas about how climate produces a certain type of soil, but there are many exceptions to what we will learn right now (Figure 1.1). Just some of the thousands of soil types. Deciduous trees, the trees that lose their leaves each winter, need at least 65 cm of rain per year. These forests produce soils called pedalfers, which are common in many areas of the temperate, eastern part of the United States (Figure 1.2). The word pedalfer comes from some of the elements that are commonly found in the soil. The "Al" in pedalfer is the chemical symbol of the element aluminum, and the "Fe" in pedalfer is the chemical symbol for iron. Pedalfers are usually a very fertile, dark brown or black soil. Not surprisingly, they are rich in aluminum clays and iron oxides. Because a great deal of rainfall is common in this climate, most of the soluble minerals dissolve and are carried away, leaving the less soluble clays and iron oxides behind. A pedalfer is the dark, fertile type of soil that will form in a forested region. Pedocal soils form in drier, temperate areas where grasslands and brush are the usual types of vegetation (Figure chemical weathering and less water to dissolve away soluble minerals, so more soluble minerals are present and fewer clay minerals are produced. It is a drier region with less vegetation, so the soils have lower amounts of organic material and are less fertile. A pedocal is named for the calcite enriched layer that forms. Water begins to move down through the soil layers, but before it gets very far, it begins to evaporate. Soluble minerals, like calcium carbonate, concentrate in a layer that marks the lowest place that water was able to reach. This layer is called caliche. A lizard on soil typical of an arid region in Mexico. In tropical rainforests where it rains literally every day, laterite soils form (Figure 1.4). In these hot, wet, tropical regions, intense chemical weathering strips the soils of their nutrients. There is practically no humus. All soluble minerals are removed from the soil and all plant nutrients are carried away. All that is left behind are the least soluble materials, like aluminum and iron oxides. These soils are often red in color from the iron oxides. Laterite soils bake as hard as a brick if they are exposed to the Sun. A laterite is the type of thick, nutrient-poor soil that forms in the rainforest. Many climate types have not been mentioned here. Each produces a distinctive soil type that forms in the particular circumstances found there. Where there is less weathering, soils are thinner but soluble minerals may be present. Where there is intense weathering, soils may be thick but nutrient-poor. Soil development takes a very long time, it may take hundreds or even thousands of years for a good fertile topsoil to form. Soil scientists estimate that in the very best soil-forming conditions, soil forms at a rate of about 1mm/year. In poor conditions, soil formation may take thousands of years!


Output: this type of soil forms in tropical rainforests.