Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Q: Context: Highly conserved sequences at the 5' splice site and branch site of U12-dependent introns are important determinants for splicing by U12-dependent spliceosomes. This study investigates the in vivo splicing phenotypes of mutations in the branch site consensus sequence of the U12-dependent intron F from a human NOL1 (P120) minigene. Intron F contains a fully consensus branch site sequence (UUCCUUAAC). Mutations at each position were analyzed for their effects on U12-dependent splicing in vivo. Mutations at most positions resulted in a significant reduction of correct U12-dependent splicing. Defects observed included increased unspliced RNA levels, the activation of cryptic U2-dependent 5' and 3' splice sites, and the activation of cryptic U12-dependent branch/3' splice sites. A strong correlation was observed between the predicted thermodynamic stability of the branch site: U12 snRNA interaction and correct U12-dependent splicing. The lack of a polypyrimidine tract between the branch site and 3' splice site of U12-dependent introns and the observed reliance on base-pairing interactions for correct U12-dependent splicing emphasize the importance of RNA/RNA interactions during U12-dependent intron recognition and proper splice site selection. 
 Question: Which is the branch site consensus sequence in U12-dependent introns?

A: uuccuuaac
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Q: Context: Mandy Hering (born 11 March 1984) is a German handball player. 
 Question: To which sports is Mandy Hering related?

A: handball
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Q: Context: A common misconception is that the Sun is closer to Earth in the summer and farther away from it during the winter. Instead, the seasons are caused by the 23.5o tilt of Earths axis of rotation relative to its plane of orbit around the Sun (Figure 1.1). Solstice refers to the position of the Sun when it is closest to one of the poles. At summer solstice, June 21 or 22, Earths axis points toward the Sun and so the Sun is directly overhead at its furthest north point of the year, the Tropic of Cancer (23.5o N). During the summer, areas north of the Equator experience longer days and shorter nights. In the Southern Hemi- sphere, the Sun is as far away as it will be and so it is their winter. Locations will have longer nights and shorter days. The opposite occurs on winter solstice, which begins on December 21. More about seasons can be found in the Atmospheric Processes chapter. Different parts of the Earth receive different amounts of solar radiation. Which part of the planet receives the most solar radiation? The Suns rays strike the surface most directly at the Equator. Different areas also receive different amounts of sunlight in different seasons. What causes the seasons? The seasons are caused by the direction Earths axis is pointing relative to the Sun. The Earth revolves around the Sun once each year and spins on its axis of rotation once each day. This axis of rotation is tilted 23.5o relative to its plane of orbit around the Sun. The axis of rotation is pointed toward Polaris, the North Star. As the Earth orbits the Sun, the tilt of Earths axis stays lined up with the North Star. The North Pole is tilted towards the Sun and the Suns rays strike the Northern Hemisphere more directly in summer (Figure 1.2). At the summer solstice, June 21 or 22, the Suns rays hit the Earth most directly along the Tropic of Cancer (23.5o N); that is, the angle of incidence of the Suns rays there is zero (the angle of incidence is the deviation in the angle of an incoming ray from straight on). When it is summer solstice in the Northern Hemisphere, it is winter solstice in the Southern Hemisphere. Winter solstice for the Northern Hemisphere happens on December 21 or 22. The tilt of Earths axis points away from the Sun (Figure 1.3). Light from the Sun is spread out over a larger area, so that area isnt heated as much. With fewer daylight hours in winter, there is also less time for the Sun to warm the area. When it is winter in the Northern Hemisphere, it is summer in the Southern Hemisphere. Halfway between the two solstices, the Suns rays shine most directly at the Equator, called an equinox (Figure 1.4). The daylight and nighttime hours are exactly equal on an equinox. The autumnal equinox happens on September 22 or 23 and the vernal, or spring, equinox happens March 21 or 22 in the Northern Hemisphere. Summer solstice in the Northern Hemisphere. Click image to the left or use the URL below. URL: 
 Question: this refers to when the position of the sun is closest to one of the poles.

A:
solstice
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