Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

[Q]: Unusual pigmentary changes associated with 5-fluorouracil therapy.
[A]: adverse drug event


[Q]: Ultrastructurally the follicular cells contained large residual bodies composed of abundant electron-lucent lipid droplets of variable size.
[A]: non-adverse drug event


[Q]: Massive prolapse of the urethral mucosa following periurethral injection of calcium hydroxylapatite for stress urinary incontinence.
[A]:
adverse drug event