Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: Chronic myeloid leukemia (CML) is characterized by the Philadelphia translocation that fuses BCR sequences from chromosome 22 upstream of the ABL gene on chromosome 9. The chimerical Bcr-Abl protein expressed by CML cells has constitutive tyrosine kinase activity, which is essential for the pathogenesis of the disease. Imatinib, an ATP-competitive selective inhibitor of Bcr-Abl, has unprecedented efficacy for the treatment of CML. Most patients with early stage disease achieve durable complete hematological and complete cytogenetic remissions, with minimal toxicity. In contrast, responses are less stable in patients with advanced CML. This review highlights the pathogenesis of CML, its clinical features, and the development of imatinib as a specific molecularly targeted therapy. Aspects of disease monitoring and side effects are covered as well as resistance to imatinib and strategies to overcome resistance, such as alternative signal transduction inhibitors and drug combinations. Perspectives for further development are also discussed.

Answer: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Question: The Bacillus anthracis toxin genes, cya, lef, and pag, can be viewed as a regulon, in which transcription of all three genes is activated in trans by the same regulatory gene, atxA, in response to the same signal, CO2. In atxA+ strains, toxin gene expression is increased 5- to 20-fold in cells grown in 5% CO2 relative to cells grown in air. CO2-enhanced toxin gene transcription is not observed in atx4-null mutants. Here, we used two independent techniques to obtain evidence for additional CO2-induced atxA-regulated genes. First, total protein preparations from atxA4+ and atxA isolates grown in 5% CO2 and in air were examined by two-dimensional electrophoresis. Comparison of the resulting protein patterns indicated that synthesis of non-toxin proteins is influenced by growth in elevated CO2 and the toxin gene regulator, atxA. Second, we generated random transcriptional lacZ fusions in B. anthracis with transposon Tn917-LTV3. Transposon-insertion libraries were screened for mutants expressing CO2-enhanced atxA-dependent beta-galactosidase activity. DNA sequence analysis of transposon insertion sites in 17 mutants carrying CO2- and atxA-regulated fusions revealed 10 mutants carrying independent insertions on the 185-kb toxin plasmid pXO1 which did not map to the toxin genes. The tcr-lacZ fusion mutants (tcr for toxin coregulated) were Tox+, indicating that these genes may not be involved in anthrax toxin gene activation. Our data indicate a clear association of atxA with CO2-enhanced gene expression in B. anthracis and provide evidence that atxA regulates genes other than the structural genes for the anthrax toxin proteins.

Answer: Which metabolite activates AtxA?


Question: The Sun and all the objects that are held by the Suns gravity are known as the solar system. These objects all revolve around the Sun. The ancient Greeks recognized five planets. These lights in the night sky changed their position against the background of stars. They appeared to wander. In fact, the word planet comes from a Greek word meaning wanderer. These objects were thought to be important, so they named them after gods from their mythology. The names for the planets Mercury, Venus, Mars, Jupiter, and Saturn came from the names of gods and a goddess. The ancient Greeks thought that Earth was at the center of the universe, as shown in Figure 25.1. The sky had a set of spheres layered on top of one another. Each object in the sky was attached to one of these spheres. The object moved around Earth as that sphere rotated. These spheres contained the Moon, the Sun, and the five planets they recognized: Mercury, Venus, Mars, Jupiter, and Saturn. An outer sphere contained all the stars. The planets appear to move much faster than the stars, so the Greeks placed them closer to Earth. Ptolemy published this model of the solar system around 150 AD. About 1,500 years after Ptolemy, Copernicus proposed a startling idea. He suggested that the Sun is at the center of the universe. Copernicus developed his model because it better explained the motions of the planets. Figure 25.2 shows both the Earth-centered and Sun-centered models. Copernicus did not publish his new model until his death. He knew that it was heresy to say that Earth was not the center of the universe. It wasnt until Galileo developed his telescope that people would take the Copernican Today we know that we have eight planets, five dwarf planets, over 165 moons, and many, many asteroids and other small objects in our solar system. We also know that the Sun is not the center of the universe. But it is the center of the solar system. Figure 25.3 shows our solar system. The planets are Mercury, Venus, Earth, Mars, Jupiter, Saturn, Uranus, and Neptune. Table 25.1 gives some data on the mass and diameter of the Sun and planets relative to Earth. Object Mass (Relative to Earth) Sun Mercury Venus Earth Mars Jupiter Saturn Uranus 333,000 Earths mass 0.06 Earths mass 0.82 Earths mass 1.00 Earths mass 0.11 Earths mass 317.8 Earths mass 95.2 Earths mass 14.6 Earths mass Diameter of Planet (Relative to Earth) 109.2 Earths diameter 0.39 Earths diameter 0.95 Earths diameter 1.00 Earths diameter 0.53 Earths diameter 11.21 Earths diameter 9.41 Earths diameter 3.98 Earths diameter Neptune 17.2 Earths mass Youve probably heard about Pluto. When it was discovered in 1930, Pluto was called the ninth planet. Astronomers later found out that Pluto was not like other planets. For one thing, what they were calling Pluto was not a single object. They were actually seeing Pluto and its moon, Charon. In older telescopes, they looked like one object. This one object looked big enough to be a planet. Alone, Pluto was not very big. Astronomers also discovered many objects like Pluto. They were rocky and icy and there were a whole lot of them. Astronomers were faced with a problem. They needed to call these other objects planets. Or they needed to decide that Pluto was something else. In 2006, these scientists decided what a planet is. According to the new definition, a planet must: Orbit a star. Be big enough that its own gravity causes it to be round. Be small enough that it isnt a star itself. Have cleared the area of its orbit of smaller objects. If the first three are true but not the fourth, then that object is a dwarf planet. We now call Pluto a dwarf planet. There are other dwarf planets in the solar system. They are Eris, Ceres, Makemake and Haumea. There are many other reasons why Pluto does not fit with the other planets in our solar system. Figure 25.4 shows the Sun and planets with the correct sizes. The distances between them are way too small. In general,

Answer:
The planet that is most similar to Earth in mass and diameter is