Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: Molecular abnormalities caused by the hybrid Bcr-Abl gene are causally associated with the development and progression of Philadelphia chromosome-positive (Ph(+)) chronic myelogenous leukemia (CML). Imatinib mesylate (STI571), a specific Bcr-Abl tyrosine-kinase signal-transduction inhibitor, has shown encouraging activity in phase I and II studies of CML. Here, we describe the use of imatinib mesylate to treat 75 patients in blast-phase CML (median age, 53 years; 65 with nonlymphoid and 10 with lymphoid blasts), and compare the results with those of a historical control group treated with standard cytarabine-based therapy. Imatinib mesylate was given as oral doses at 300 to 1000 mg per day and was the first salvage therapy for 47 patients. The objective response rate was 52% (39 of 75 patients: 16 had complete and 3 had partial hematologic response; 12 had hematologic improvement; 7 returned to second chronic phase; and 1 had a complete response in extramedullary blastic disease). Response rates were not different between nonlymphoid and lymphoid groups. The cytogenetic response rate was 16% (12 patients: 5 complete, 3 partial [Ph(+) below 35%], and 4 minor [Ph(+), 34% to 90%]). The estimated median overall survival was 6.5 months; the estimated 1-year survival was 22%. Response to therapy (landmark analysis at 8 weeks) was associated with survival prolongation. Compared with standard cytarabine combinations, imatinib mesylate therapy was less toxic and produced a higher response rate (55% versus 29%, P =.001), longer median survival (7 versus 4 months, P =.04), and lower 4-week induction mortality (4% versus 15%, P =.07). Imatinib mesylate is currently being tested in combination with other drugs to improve the prognosis for blast-phase CML.

A: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
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Q: The movie opens with James Reece (Jonathan Rhys Meyers) driving through the streets of Paris in a black SUV to work. Reece works in the American Embassy as an aide to Ambassador Bennington (Richard Durden), the U.S. Ambassador to France. Taking a delivery of some forms from the Ambassador's secretary, he goes over Bennington's itinerary for the next few days, centering around a major summit in which the U.S., France, and several other nations are preparing foreign aid to the African continent. Bennington shows that he is more absorbed right now in a chess game he's playing with Reece during all this time. Despite paying less attention to the board and the game than Bennington is, Reece quickly checkmates him to win.Reece receives a call from an unknown source (voiced by David Gasman) directing him to a silver BMW in the parking lot, excusing himself with a cover story to Bennington that he has to review the Summit's planned seating arrangement. Going to the parking lot, Reece opens a code-locked security compartment in the trunk of his SUV to reveal a firearm and several French license plates. He removes the license plate from the silver BMW and replaces it with one of the plates he has stowed away in his SUV. He then moves his SUV to another parking space and waits there, watching the silver BMW. He watches several men get into the vehicle, put a briefcase into its trunk, and drive away.Arriving home, Reece gets another call from the same source. Reece is in fact a CIA operative working in the Embassy as a cover. He does minor jobs for his superiors, and is eager to move up into Special Ops. His superior assures him he'll get his chance, but for right now he is needed to secure a hidden transmission chip in the French Foreign Minister's office during a meeting with Ambassador Bennington. Reece doesn't believe he was given a chip, but is told it's in his left jacket pocket. Checking his jacket, he finds the chip there.Sitting in his apartment, Reece examines the chip. He is interrupted by a knock on his door. It's his girlfriend, Caroline (Kasia Smutnak) (pronounced Cah-roll-een, the 'ine' being pronounced like in the word 'magazine'). Caroline kisses Reece and tells him she has a surprise. She sits him in a chair and makes him keep his back to her. He can hear her undressing and changing into a different outfit. When she tells him to look, his jaw drops at the sight of her wearing a sexy strapless dress. He thinks he recognizes the fabric, and Caroline tells him she made it out of their bedroom curtains-- Caroline is a clothing designer. The two of them quickly start to undress as they head into the bedroom to make out.Reece arrives the next day at the conference site to give Bennington a summary of what is intended to be discussed at the meeting. Bennington invites Reece to attend the meeting with him.During the meeting, Reece discreetly takes the chip (disguising it by putting a piece of gum in his mouth and offering another piece to the Minister's secretary) and tries to put it under the lampstand beside his seat, using his chewing gum as an adhesive. However, the gum fails to hold and twice it falls back to the floor in plain sight. Frustrated, and barely managing to keep the chip hidden, as a diversion Reece finally questions the Foreign Minister (Eric Godon) about his having several Goyas in his office. The Minister says he does, and offers to show them to Bennington, who is very interested in Goya art. As Bennington accompanies the Minister and secretary to see the Goyas, leaving Reece alone in the meeting room, Reece takes the stapler from the Minister's desk and staples the chip to the underside of the desk... but accidentally leaves the stapler open as he exits.Arriving home that evening, Reece is disquieted as the lights in the hallway go out. He finds what looks like a trail of blood leading to a door out onto the roof of the building. Grabbing a broom left in

A: What are the terrorists targeting?
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Q: The figure of a limp woman with long curly hair is seen drifting underwater, and a voiceover questions the end of a life that never truly existed. This life ended in murder, the victim herself unsure of who her killer was and why she was killed. Her death was only metaphorical, for in her place a new life begins.The story starts with Patience Phillips (Halle Berry), a timid woman who can't stand up for herself. She lets people walk all over her, and has wasted her artistic talent working for a cosmetic company as a graphic designer. George Hedare (Lambert Wilson) runs the company with his supermodel wife, Laurel (Sharon Stone). Laurel knows that Patience is capable, but seems mostly indifferent, only using her in own power struggles with her husband. George, an abusive boss in general, finds plenty of opportunity to mock Laurel.The company is about to launch BeauLine, a new anti-aging product that Laurel had secretly been using for years. The advertisement is designed by Patience but George, unsatisfied, demands that she redesigns it. Upset and frustrated, Patience returns home and sees a cat looking up at her. Shaking her head, she goes to sleep, but her loud neighbours keeps her up and she is unable to rest. Next morning, the cat is on her window ledge. When she approaches, she realizes the cat has climbed up to a higher ledge and was potentially stuck. To try and reach the cat, Patience climbs out her window ledge, and a passing detective mistakens her intentions as suicidal. He ends up rushing into her apartment and pulling her back in. Patience would have thanked him but realizes she is late for work, in her hurry to leave she drops her wallet. The detective, Tom Lone (Benjamin Bratt), tracks her down to her workplace and returns it to her, and both agree to a coffee date.Later that night, Patience goes to the production factory to deliver her artwork, and she accidentally hears that the BeauLine has unsafe health problems. Stunned, she backs into several tools, revealling her presence. Two men chase her into a large waste water pipe, where she is trapped, and they flush her into the river, where she drowns. The cat that has been appearing in front of Patience appears by her body and gathers several other cats around her.Patience eventually drags herself unsteadily up and returns home. Her movements are off and uncontrollable, and she ends up breaking the glass through her own window. When her neighbours start their usual loud party again, she yells at them to quiet but they again ignore her. The old Patience would have backed down, but now she strodes down, knocks on their door, and promptly beats up the host and destroys the music equipment in front of many shocked guests. When she wakes up the next morning, she almost dismisses everything as a dream until she sees the broken glass. Unfortunately, her memories of what happened before that are blank, and so she cluelessly returns back to work.At work, George loudly yells at Patience in front of all her coworkers for not handling in her project. She tunes him out, which angers him further, and when she apologizes he only continues. Patience than apologizes for wasting her time in the company, and is fired, but as soon as George leaves her colleagues swarm around her in congratulations. Patience packs up her things and while she and her friends are walking home, two dogs instantly begin barking at her and she instinctively hisses at them. When questioned, she explains her behaviour as allergies. When they pass by a jewelry store, Patience's attention is caught by a beautiful collar-like necklace, but is reminded of her new unemployed status and leaves longingly. Once home, she sees the same cat again, and finally close enough she was able to find the address on the cat's owner.The cat belonged to an older woman named Ophelia, a former professor who lived alone in a house full of cats. She explains that the cat constantly appearing in front of Patience is named Midnight, a rare Egyptian

A:
What does the skincare cream, Baeu-line, reverse?
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