Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Ex Input:
In patients who show abnormal liver function tests, the immediate discontinuation of gliclazide is recommended.

Ex Output:
non-adverse drug event


Ex Input:
The patient was successfully treated by discontinuation of cyclosporine and mycophenolate mofetil, initiation of systemic amphotericin B, and aggressive surgical debridement.

Ex Output:
non-adverse drug event


Ex Input:
Recent efforts have focused on heightened surveillance to detect contamination before transfusion to limit recipient morbidity and mortality.

Ex Output:

non-adverse drug event