Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: It is unanimously accepted that there is an unmet need for pain medications that are both effective and safe. Unfortunately, no really novel analgesics have been approved over the past three decades. In view of both experimental and clinical evidence of a major role for nerve growth factor (NGF) in the generation and maintenance of a wide range of pain states, drug discovery efforts focusing on the development of anti-NGF agents have aroused particular interest. Several humanized anti-NGF monoclonal antibodies (mAbs) have entered clinical trials as potential analgesics. In this respect, tanezumab is at an advanced stage of clinical development while fulranumab, fasinumab and ABT-110, previously known as PG110, are in early phases of clinical development. This Current Opinion article aims at describing the rationale for targeting NGF for pain, reviewing the analgesic efficacy and safety of anti-NGF agents based on data from fully published studies, conference abstracts, and the US Food and Drug Administration (FDA) website, and discussing the possible future of these agents in managing chronic pain. Anti-NGF mAbs produced significant pain relief and functional improvement in patients with osteoarthritis of the knee and/or hip. Conversely, studies in non-specific lower back pain generated mixed results; overall, this condition appeared to be less responsive to anti-NGF agents than osteoarthritis. Finally, there was no conclusive evidence of the effectiveness of anti-NGF mAbs in some types of chronic visceral or neuropathic pain. Furthermore, these studies raised safety concerns about anti-NGF mAbs. As a class, these drugs may cause or worsen peripheral neuropathies. But the most problematic issue-which prompted the FDA to place studies of these compounds on clinical hold in 2010-was rapid joint destruction leading to joint replacement surgery. The aetiologies of these side effects have been much debated and their pathophysiology is poorly understood. After an Arthritis Advisory Committee meeting held in March 2012, pharmaceutical companies negotiated with the FDA on the conditions for restarting clinical studies. Although the FDA lifted its clinical hold, there remain many unresolved issues about the long-term efficacy and safety of anti-NGF mAbs. While acknowledging that the future of these drugs is unforeseeable, it appears that they may not be the safe and effective painkillers that have been awaited for decades. 
 Question: What is the target of tanezumab?
ngf

Context: New England, the late 1950s. Todd Anderson (Ethan Hawke), a lonely and painfully shy teenager, who is under pressure by his stern parents because he must live up to his older brother's reputation to attend Yale and become a lawyer, arrives for the new semester at the Welton Academy for boys -- Todd's brother also attended Welton and was a popular and well-regarded student there. This semester begins during an orientation gathering with a speech given by the stern Headmaster Nolan (Norman Lloyd), who states the academy's four pillars: Tradition, Honor, Discipline, and Excellence. Todd meets Neil Perry (Robert Sean Leonard) an ambitious student whom becomes his dorm roommate.Later in his dorm, Neil is ordered by his grumpy and domineering father (Kurtwood Smith) to drop his involvement with the school annual in order to maintain good grades so the boy may become a doctor much as he has done. Neil is under pressure from his stern father's will. Also, Mr. Perry tells Neil that Mrs. Perry also wants him to become a doctor, which further worries the boy. A little later, Todd tells Neil that he is in a similar situation with his parents involving his older brother who also attended Welton a few years ago, graduated, and attended Yale Law School and became a lawyer and his parents want the exact same thing for him. But Todd does not have the courage to tell his parents that he instead wants to be a writer, not a lawyer.During the first day of classes Todd and Neil experience the various teaching methods which include speeches by the trig teacher, as well as the Latin teacher, and the math teacher who states that "all 20 questions at the end of the first chapter are due tomorrow". In stark contrast to these orthodox teaching methods, the guys see a different side of the school when they attend English class taught by the newly arrived (and liberal-minded) Mr. Keating (Robin Williams), whom they met briefly during the orientation -- Keating tells his class he was also a student at Welton ("Helton" as the students secretly refer to the institution) himself many years ago. Keating enters his class whistling the 1812 Overture, and he first takes the boys out in the hallway to the school's displays cases containing artifacts of the school's sports achievements. He tells them that they all have the potential to become powerful individuals, and they are responsible for what their futures will hold. These two actions show his difference from the other teachers because no other teacher would commit the actions he does. Also, he tells the boys they may call him "Oh Captain, my Captain", if they dare. These examples of Mr. Keating's teachings show the boys how to think for themselves. Mr. Keating then tells the boys "Carpe Diem", which is Latin for "seize the day".In addition to Todd and Neil, a small group of other students whom include the lovesick Knox Overstreet (Josh Charles), the flip Charlie Dalton (Gale Hansen), the pragmatic Richard Cameron (Dylan Kussman), liberal Steven Meeks (Allelon Ruggiero) and the moderate Gerard Pitts (James Waterston), also react to the first day's lesson with comments from "that was weird" to "neat". Cameron asks if anything Keating told them will be on a future test and the boys respond with mild scorn.The next day Keating starts the class with a traditional teaching approach by having Neil read out loud the introduction to their poetry textbook, which describes how to rate the quality of poetry according to mathematical plotting. Keating finds such mathematical criticism ridiculous and instructs his pupils to rip out the essay which is one of three ways that he demonstrates freedom of expression and non-conformity. When some students hesitate, he tells them "this is not the Bible. This is a battle, a war. You will have to learn to think for yourselves." He later has the students stand on his desk as a reminder to look at the world in a different way.A few days later, Knox Overstreet is asked to attend a dinner party at the Danburry 
 Question: Who does Nolan warn?
todd anderson

Context: The 49ers featured one of the best running games in the NFL in 1976 NFL season. Delvin Williams emerged as an elite back, gaining over 1,200 yards rushing and made the Pro Bowl. Wilbur Jackson also enjoyed a resurgence, rushing for 792 yards. Once again Gene Washington was the teams leading receiver with 457 yards receiving and six scores. The 49ers started the season 61 for their best start since 1970. Most of the wins were against second-tier teams, although the 49ers did shut out the Rams 160, in 1976 Los Angeles Rams season on Monday Night Football. In that game the 49ers recorded 10 sacks, including 6 by Tommy Hart. However, the 49ers lost four games in a row, including two against divisional rivals Los Angeles and 1976 Atlanta Falcons season that proved fatal to their playoff hopes. Louis G. Spadia retired from the 49ers in 1977 upon the teams sale to the DeBartolo Family. The team was sold to Edward J. DeBartolo Jr. in March 1977, and despite finishing the season with a winning record of 86, Clark was fired after just one season by newly hired general manager Joe Thomas (American football executive), who oversaw the worst stretch of football in the teams history. 
 Question: What was the 49ers regular season record in 1976?

8–6