In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

[Q]: Paragraph: Cytokine expression patterns of T cells can be regulated by pre-commitment to stable effector phenotypes, further modification of moderately stable phenotypes, and quantitative changes in cytokine production in response to acute signals. We showed previously that the epidermal growth factor family member Amphiregulin is expressed by T cell receptor-activated mouse CD4 T cells, particularly Th2 cells, and helps eliminate helminth infection. Here we report a detailed analysis of the regulation of Amphiregulin expression by human T cell subsets. Signaling through the T cell receptor induced Amphiregulin expression by most or all T cell subsets in human peripheral blood, including naive and memory CD4 and CD8 T cells, Th1 and Th2 in vitro T cell lines, and subsets of memory CD4 T cells expressing several different chemokine receptors and cytokines. In these different T cell types, Amphiregulin synthesis was inhibited by an antagonist of protein kinase A, a downstream component of the cAMP signaling pathway, and enhanced by ligands that increased cAMP or directly activated protein kinase A. Prostaglandin E2 and adenosine, natural ligands that stimulate adenylyl cyclase activity, also enhanced Amphiregulin synthesis while reducing synthesis of most other cytokines. Thus, in contrast to mouse T cells, Amphiregulin synthesis by human T cells is regulated more by acute signals than precommitment of T cells to a particular cytokine pattern. This may be appropriate for a cytokine more involved in repair than attack functions during most inflammatory responses. 
 Title: The Acute Environment, Rather than T Cell Subset Pre- Commitment, Regulates Expression of the Human T Cell Cytokine Amphiregulin
[A]: False


[Q]: Paragraph: The tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections. 
 Title: Prediction of quaternary assembly of SARS coronavirus peplomer
[A]: False


[Q]: Paragraph: Cell fusion is a powerful tool for understanding the molecular mechanisms of epigenetic reprogramming. In hybrid cells of somatic cells and pluripotential stem cells, including embryonic stem (ES) and embryonic germ cells, somatic nuclei acquire pluripotential competence. ES and embryonic germ cells retain intrinsic trans activity to induce epigenetic reprogramming. For generating hybrid cells, we have used the technique of electrofusion. Electrofusion is a highly effective, reproducible, and biomedically safe in vitro system. For successful cell fusion, two sequential steps of electric pulse stimulation are required for the alignment (pearl chain formation) of two different types of cells between electrodes in response to alternating current stimulation and for the fusion of cytoplasmic membranes by direct current stimulation. Optimal conditions for electrofusion with a pulse generator are introduced for ES and somatic cell fusion. Topics in the field of stem cell research include the successful production of cloned animals via the epigenetic reprogramming of somatic cells and contribution of spontaneous cell fusion to generating intrinsic plasticity of tissue stem cells. Cell fusion technology may make important contributions to the fields of epigenetic reprogramming and regenerative medicine. derived from parental cells coordinately regulates the new phenotypes and functions of somatic hybrid cells. One well-known cell fusion phenomenon occurring in vivo is fertilization. The union of two pronuclei from an MII oocyte and sperm creates the next generation with genetic diversity. Soon after fertilization, sperm chromatin is reprogrammed by nucleoplasmin because of the exchange of sperm-specific basic proteins to histones (2), almost resulting in the equalization of paternal and maternal chromatin through subsequent cell divisions. Cell fusion is also involved in the technique of animal cloning. The somatic donor nucleus is introduced into a recipient MII oocyte by cell fusion or direct injection. In the cloned embryos, the somatic type of cell phenotype and function is reprogrammed to the pluripotential type as a result of genomewide epigenetic modifications via the activity of trans-acting factors preserved in unfertilized oocytes. This phenomenon has been called nuclear reprogramming. Using electrofusion between ES cells and adult somatic cells, it has been demonstrated that ES cells have an intrinsic capacity for the nuclear reprogramming of specialized somatic genomes (3,4) . In hybrid cells of ES cells and thymocytes, epigenetic modifications specific to somatic cells are fully reprogrammed to the ES epigenotype, as shown by (1) the successful contribution of the ES hybrid cells to the normal embryogenesis of chimeric embryos, (2) reactivation of the inactivated X chromosome derived from female thymocytes, (3) reactivation of pluripotential cellspecific genes (Oct4 and Tsix) derived from somatic cells, (4) tissue-specific gene expression from the reprogrammed somatic genomes after in vivo and in vitro differentiation, and (5) de-condensed chromatin formation in the reprogrammed somatic nuclei as marked by histone-tail modifications of H3 and H4 hyperacetylation and H3 lysine 4 hypermethylation (3,5,6) . Moreover, embryonic germ (EG) cells derived from gonadal primordial germ cells of mouse E11.5 and 12.5 embryos, in which the majority of parental imprints are erased (7), possess additional activity for inducing reprogramming of parental imprints on somatic genomes accompanied by DNA demethylation in the EG hybrid cells (8). Therefore, electrofusion between pluripotential stem cells and somatic cells will contribute to our understanding of the mechanisms of nuclear reprogramming involved in epigenetic modifications on DNA and chromatin. Cell fusion was first induced by the Sendai virus (HVJ) among Ehrlich's ascites tumor cells, resulting in the formation of giant polynuclear cells (9). Since Harris's group reported cell fusion between two different species, mouse and human, in 1965 (10), the technique has proven to be a powerful approach to analyzing biological interactions between differentiated cell types. Various techniques lead to cell fusion mediated by other viruses such as Paramyxoviruses, including Oncornavirus, Coronavirus, Herpesvirus, and Poxvirus and by treatment with various chemical agents such as calcium ions, lysolecithin, and polyethylene glycol (PEG). However, virus-and chemicalmediated cell fusion has difficulties with respect to the efficiency of inducing cell fusion and reproducibility and biomedical safety for clinical applications. Since the 1980s, efforts have been made to optimize many parameters of electrofusion, resulting in improvements in fusion efficiency, which is now significantly better than that of cell 
 Title: Nuclear Reprogramming of Somatic Nucleus Hybridized With Embryonic Stem Cells by Electrofusion
[A]:
False