Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

[EX Q]: Context: Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, demonstrated efficacy and safety in moderate-to-severe plaque psoriasis when administered via subcutaneous injection. Self-administration by pre-filled syringe (PFS) can offer patients clinical benefits of a drug, with increased convenience. To assess efficacy, safety and usability of secukinumab administration via PFS in subjects with moderate-to-severe plaque psoriasis. Subjects in this phase 3 trial were randomized 1:1:1 to secukinumab 300 or 150mg or matching placebo. Results to week 12 are presented here. Each treatment was delivered using a PFS once weekly to week 4, and again at week 8. Co-primary endpoints were secukinumab superiority over placebo for week 12 PASI 75 (75% reduction in Psoriasis Area and Severity Index) and IGA mod 2011 (2011 modified Investigator's Global Assessment) 0/1 response rates. Secondary endpoints included PFS usability, determined by observer rating of successful, hazard-free self-injection and subject rating of acceptability by the Self-Injection Assessment Questionnaire (SIAQ). Co-primary endpoints were met, with demonstration of superiority for each secukinumab dose vs. placebo at week 12 (PASI 75: 759%, 695% and 0% for secukinumab 300mg, 150mg and placebo; IGA mod 2011 0/1: 690%, 525% and 0%, respectively; P<00001 for all comparisons vs. placebo). PFS usability was high: 100% of subjects successfully self-administered treatment at week 1, and subjects reported high SIAQ-assessed acceptability of the PFS throughout the trial. No new/unexpected safety signals were observed. Secukinumab administration by PFS was effective, with an acceptable safety profile and high usability. The PFS provides a reliable, convenient form of secukinumab administration in subjects with moderate-to-severe plaque psoriasis. 
 Question: Which molecule is targeted by a monoclonal antibody Secukinumab?
[EX A]: interleukin-17a

[EX Q]: Context: NADPH oxidase (Nox) family enzymes are one of the main sources of cellular reactive oxygen species (ROS), which have been shown to function as second messenger molecules. To date, seven members of this family have been reported, including Nox1-5 and Duox1 and -2. With the exception of Nox2, the regulation of the Nox enzymes is still poorly understood. Nox1 is highly expressed in the colon, and it requires two cytosolic regulators, NoxO1 and NoxA1, as well as the binding of Rac1 GTPase, for its activity. In this study, we investigate the role of the tyrosine kinase c-Src in the regulation of ROS formation by Nox1. We show that c-Src induces Nox1-mediated ROS generation in the HT29 human colon carcinoma cell line through a Rac-dependent mechanism. Treatment of HT29 cells with the Src inhibitor PP2, expression of a kinase-inactive form of c-Src, and c-Src depletion by small interfering RNA (siRNA) reduce both ROS generation and the levels of active Rac1. This is associated with decreased Src-mediated phosphorylation and activation of the Rac1-guanine nucleotide exchange factor Vav2. Consistent with this, Vav2 siRNA that specifically reduces endogenous Vav2 protein is able to dramatically decrease Nox1-dependent ROS generation and abolish c-Src-induced Nox1 activity. Together, these results establish c-Src as an important regulator of Nox1 activity, and they may provide insight into the mechanisms of tumor formation in colon cancers. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
[EX A]: nadph oxidase 1

[EX Q]: Context: After their season-opening loss to the Chargers, the Bears rebounded by winning their home opener against the Kansas City Chiefs. Bernard Berrian fumbled on the team's opening drive, but a staunch defensive effort held the Chiefs at bay, and eventually allowed the Bears to engineer a successful drive. John St. Clair, a reserve offensive tackle, scored the Bears' first offensive touchdown of the season from a one-yard pass from Rex Grossman. The team forced the Chiefs to punt on their next drive, which was returned for a touchdown by Devin Hester.The Chiefs scored their first points of the game after Damon Huard threw a sixteen-yard touchdown pass to Dwayne Bowe. During halftime, the Bears received the Pro Team Community Award for their charity efforts. The Bears' defense held the Chiefs to only three more points, after forcing pivotal turnovers in two red zone situations and also a blocked field goal attempt. Pro Bowlers Brian Urlacher, Lance Briggs, and Tommie Harris each recorded sacks, and forced Larry Johnson and Huard to leave the game with injuries. Cedric Benson recorded his first one hundred-yard rushing game. With 20-10 win, the Bears advanced to 1-1 record. Q2 - CHI - 10:29 - 2-yard TD pass from Rex Grossman to John St. Clair (Robbie Gould kick) (CHI 7-0) Q2 - CHI - 9:33 - Devin Hester 73-yard punt return TD (Gould kick) (CHI 14-0) Q2 - CHI - 2:30 - Robbie Gould 47-yard FG (CHI 17-0) Q2 - KC - 1:24 - 16-yard TD pass from Damon Huard to Dwayne Bowe (Dave Rayner kick) (CHI 17-7) Q3 - CHI - 8:36 - Robbie Gould 38-yard FG (CHI 20-7) Q3 - KC - 3:12 - Dave Rayner 45-yard FG (CHI 20-10) 
 Question: What was the longest field goal?
[EX A]:
47-yard