Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

[Q]: Context: It is unanimously accepted that there is an unmet need for pain medications that are both effective and safe. Unfortunately, no really novel analgesics have been approved over the past three decades. In view of both experimental and clinical evidence of a major role for nerve growth factor (NGF) in the generation and maintenance of a wide range of pain states, drug discovery efforts focusing on the development of anti-NGF agents have aroused particular interest. Several humanized anti-NGF monoclonal antibodies (mAbs) have entered clinical trials as potential analgesics. In this respect, tanezumab is at an advanced stage of clinical development while fulranumab, fasinumab and ABT-110, previously known as PG110, are in early phases of clinical development. This Current Opinion article aims at describing the rationale for targeting NGF for pain, reviewing the analgesic efficacy and safety of anti-NGF agents based on data from fully published studies, conference abstracts, and the US Food and Drug Administration (FDA) website, and discussing the possible future of these agents in managing chronic pain. Anti-NGF mAbs produced significant pain relief and functional improvement in patients with osteoarthritis of the knee and/or hip. Conversely, studies in non-specific lower back pain generated mixed results; overall, this condition appeared to be less responsive to anti-NGF agents than osteoarthritis. Finally, there was no conclusive evidence of the effectiveness of anti-NGF mAbs in some types of chronic visceral or neuropathic pain. Furthermore, these studies raised safety concerns about anti-NGF mAbs. As a class, these drugs may cause or worsen peripheral neuropathies. But the most problematic issue-which prompted the FDA to place studies of these compounds on clinical hold in 2010-was rapid joint destruction leading to joint replacement surgery. The aetiologies of these side effects have been much debated and their pathophysiology is poorly understood. After an Arthritis Advisory Committee meeting held in March 2012, pharmaceutical companies negotiated with the FDA on the conditions for restarting clinical studies. Although the FDA lifted its clinical hold, there remain many unresolved issues about the long-term efficacy and safety of anti-NGF mAbs. While acknowledging that the future of these drugs is unforeseeable, it appears that they may not be the safe and effective painkillers that have been awaited for decades. 
 Question: What is the target of tanezumab?
[A]: ngf


[Q]: Context: Something in chocolate could be used to stop coughs and lead to more effective medicines, say UK researchers. Their study found that theobromine , found in cocoa, was nearly a third more effective in stopping coughs than codeine, which was considered the best cough medicine at present. The Imperial College London researchers who published their results online said the discovery could lead to more effective cough treatment. "While coughing is not necessarily harmful it can have a major effect on the quality of life, and this discovery could be a huge step forward in treating this problem," said Professor Peter Barnes. Ten healthy volunteers were given theobromine, codeine or placebo, a pill that contains no medicine, during the experiment. Neither the volunteers nor the researchers knew who received which pill. The researchers then measured levels of capsaicin, which is used in research to cause coughing and as a sign of how well the medicines are stopping coughs. The team found that, when the volunteers were given theobromine, the capsaicin needed to produce a cough was around a third higher than in the placebo group. When they were given codeine they needed only slightly higher levers of capsaicin to cause a cough compared with the placebo. The researchers said that theobromine worked by keeping down a nerve activity , which cause coughing. They also found that unlike some standard cough treatments, theobromine caused no side effects such as sleepiness. 
 Question: What was used in the experiment to cause coughing?
[A]: capsaicin.


[Q]: Context: At the Kibbutz Stein in Israel in 1956, school teacher Rachel (Clarice van Houten) is reunited with Ronnie (Halina Reijn), a friend from The Hague during World War II. After Ronnie leaves, Rachel reflects on her adventures during the final days of the war.In 1944, Rachel hides from the Nazis in a farm in the Dutch countryside. In exchange for hiding her, they expect her to learn Bible verses. One day, a crippled Allied bomber drops its payload on the farmhouse, killing everyone except Rachel. Rob (Michiel Heisman), a young man from a neighboring farm, hides her in the family's greenhouse. That night, Van Gein (Peter Blok), a police officer, arrives to tell them that the Nazis know that Rachel is in the area and will hunt her down. He agrees to help Rachel and Rob escape to the Allied controlled southern part of Holland. Rachel visits her father's lawyer, Smaal (Dolf de Vries). He gives her enough money and jewels to live on for a year but warns her not to trust people so easily. Van Gein leads Rachel and Rob to a dock where other Jews wait to leave. Rachel is reunited with her parents and brother, who is recovering from an emergency appendectomy. Van Gein does not accompany the Jews on the boat trip. That evening, the boat is ambushed by a Nazi patrol boat. The Nazis immediately open fire; only Rachel survives the massacre. Before drifting down the river, she sees the Nazis loot the corpses.Rachel is found by Resistance fighters who smuggle her into The Hague by disguising her as a typhoid victim and placing her in a coffin that if properly "sealed" has sizable air holes. She is taken to a soup kitchen run by another member of the Resistance, Gerben Kuipers (Derek de Lint) and given the new name of Ellis de Vries. Eventually she is made a part of the Resistance's plans to smuggle in British guns and rations. The smugglers are led by Hans Akkermans (Thom Hoffman), an expert marksman. He and Ellis are to pose as husband and wife so the Nazis will not search their luggage on the train; the luggage is actually full of weaponry. But when the Nazi soldiers on the train clearly do intend to search all baggage, a new plan is needed. Ellis takes the bags and enters a private compartment occupied by SD Colonel Muntze (Sebastian Koch). The Nazis don't search Muntze's compartment. Ellis and Muntze are clearly attracted to each other and she accepts an offer to visit him at his office. Hans is clearly jealous.A truck carrying the British guns crashes in front of the soup kitchen. Kuiper's son, Tim (Ronald Armbrust) was driving and is arrested by the Gestapo. While the others go into hiding, Ellis arranges a meeting with Muntze hoping that she can persuade him to release Tim. Knowing he is an avid stamp collector, she takes some rare Dutch stamps to him. He invites her to a Nazi party. There she sees SS commandant Gunter Franken (Waldemar Kobus) and recognizes him as the Nazi who led the ambush against the refugee boat. Although she is sickened at his sight, she manages to sing at the party later. She and Muntze return to his suite to make love. He intuits that she is Jewish from her dyed blond hair but has fallen in love with her. She accepts a job in his office and begins work the following day. There she meets Ronnie, who is Franken's secretary/sex partner. Franken gives them a report indicating that Tim has confessed everything and is to be executed, however, Muntze refuses to sign the execution order.Ellis sees Smaal at Nazi headquarters and learns that he and Muntze have negotiated a cease fire -- if the Resistance ceases its attacks against the Nazis, the Nazis will cease its violent reprisals against Dutch civilians. However, when a hidden microphone placed by Ellis in Franken's office reveals that Franken and Van Gein have been working together to kill and rob Jews trying to escape into Allied territory, a controversy amongst the Resistance fighters ensues. Van Gein is heard 
 Question: Where is Akkermans hiding ?
[A]:
coffin