In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Input: Consider Input: Paragraph: The observations that Lymphopenia is common in severe acute respiratory syndrome (SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by SARS-CoV indicate that PBMC could be useful in identifying the gene expression profile in convalescent patients and tracing the host response to SARS-CoV infection. In this study, the altered genes expressions in the PBMC of convalescent SARS patients were investigated with suppression subtractive hybridization (SSH). We found that genes encoded by mitochondrial DNA (mtDNA) were obviously upregulated, while mitochondria were now found to be closely connected with antiviral immunity. The identification of a viral gene, M, in SSH cDNA library shows the long-term existence of SARS-CoV in vivo. In addition, some oxidative stress sensitive genes, heat shock proteins, transcription factors, and cytokines showed remarkable elevation. Thin-section electron microscope shows increased lysosome-like granule and mitochondria in PBMC of patients. These results provide important intracellular clue for tracing host response to SARS-CoV infection and suggest a role of mitochondria in that process. 
 Title: Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients

Output: True


Input: Consider Input: Paragraph: The interferon-induced transmembrane protein 3 (IFITM3) is a widely expressed potent antiviral effector of the host innate immune system. It restricts a diverse group of pathogenic, enveloped viruses, by interfering with endosomal fusion. In this report, the swine IFITM3 (sIFITM3) gene was cloned. It shares the functionally conserved CD225 domain and multiple critical amino acid residues (Y19, F74, F77, R86 and Y98) with its human ortholog, which are essential for antiviral activity. Ectopic expression of sIFITM3 significantly inhibited non-enveloped foot-and-mouth disease virus (FMDV) infection in BHK-21 cells. Furthermore, sIFITM3 blocked FMDV infection at early steps in the virus life cycle by disrupting viral attachment to the host cell surface. Importantly, inoculation of 2-day-old suckling mice with a plasmid expressing sIFITM3 conferred protection against lethal challenge with FMDV. These results suggest that sIFITM3 is a promising antiviral agent and that can safeguard the host from infection with FMDV. 
 Title: Swine interferon-induced transmembrane protein, sIFITM3, inhibits foot-and-mouth disease virus infection in vitro and in vivo

Output: True


Input: Consider Input: Paragraph: The bacterial bipartite transferrin receptor is an iron acquisition system that is required for 12 survival by several key human and animal pathogens. It consists of the TonB-dependent 13 transporter Transferrin binding protein A (TbpA) and the surface lipoprotein Transferrin binding 14 protein B (TbpB). Curiously, the Tbps are only found in host specific pathogens, and are 15 themselves host specific, meaning that they will bind to the transferrin of their host species, but 16 not to those of other animal species. While this phenomenon has long been established, neither 17 the steps in the evolutionary process that led to this exquisite adaptation for the host, nor the 18 steps that could alter it, are known. We sought to gain insight into these processes by studying 19 Tbp specificity in Histophilus somni, a major pathogen of cattle. A past study showed that whole 20 cells of H. somni specifically bind bovine transferrin, but not transferrin from sheep and goats, 21 two bovids whose transferrins share 93% amino acid sequence identity with bovine transferrin. 22 To our surprise, we found that H. somni can use sheep and goat transferrins as iron sources for 23 growth, and that HsTbpB, but not HsTbpA, has detectable affinity for sheep and goat 24 transferrins. Furthermore, a third transferrin binding protein, HsTbpA2, also showed affinity for 25 sheep and goat transferrins. Our results show that H. somni TbpB and TbpA2 act to broaden the 26 host transferrin recognition range of H. somni. 27 
 Title: Transferrin binding protein B and Transferrin binding protein A 2 expand the transferrin 1 recognition range of Histophilus somni 2 3 Running title: TbpB and TbpA2 broaden specificity of


Output: True