TASK DEFINITION: Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
PROBLEM: To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril.

SOLUTION: adverse drug event

PROBLEM: In more than 6,000 patient applications of rapid atrial pacing, there has been only one failure to convert the tachycardia.

SOLUTION: non-adverse drug event

PROBLEM: These patients were treated by the continuous administration of an estrogen-progestogen combination for 6 months.

SOLUTION:
non-adverse drug event