Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
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Question: Context: English is an important global language, but that doesn't mean it's easy to learn. Many experts have tried to make English easier for students to learn--but they weren't always successful. In 1930, Professor CK Ogden of Cambridge University invented Basic English. It had only 850 words (and just eighteen verbs) and Ogden said most people could learn it in just thirty hours. The problem was that people who learned Basic English could write and say simple messages, but they couldn't understand the answers in "real" English! It was also impossible to explain a word if it wasn't in the Basic English word list. For example, if you wanted a watermelon, you asked for "a large green fruit with the form of an egg, which has a sweet red inside and a good taste"! RE Zachrisson, a university professor in Sweden, decided that the biggest problem for learners of English was spelling, so he invented a language called Anglic. Anglic was similar to English, but with much simpler spelling. "Father" became "faadher", "new" became "nue' and "years" became "yeerz". Unfortunately for some students of English, Anglic never became popular. Even easier is the language which ships' captains use: it's called "Seaspeak". Seaspeak uses a few simple phrases for every possible situation. In Seaspeak, for example, you don't say, "I'm sorry what did you say?" or "I didn't understand, can you repeat that?" It's just "Say again." No more grammar! In the age of international communication through the Internet who knows? ... a new form of English might appear. A large number of the world's e-mails are in English and include examples of "NetLingo" like OIC (Oh, I see) and TTYL (Talk to you later). In another fifty years, English might not exist ... we will probably all speak fluent Internetish! 
 Question: According to Professor Zachrisson, what was the biggest problem for learners of English?

Answer: spelling.


Question: Context: Common cellular and molecular mechanisms including protein aggregation and inclusion body formation are involved in many neurodegenerative diseases. -Synuclein is a major component of Lewy bodies in Parkinson's disease (PD) as well as in glial cytoplasmic inclusions in multiple system atrophy (MSA). Tau is a principal component of neurofibrillary and glial tangles in tauopathies. Recently, TDP-43 was identified as a component of ubiquitinated inclusions in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. PD is traditionally considered a movement disorder with hallmark lesions in the brainstem pigmented nuclei. However, pathological changes occur in widespread regions of the central and peripheral nervous systems in this disease. Furthermore, primary glial involvement ("gliodegeneration") can be observed in PD and MSA as well as in tauopathy. The present article reviews abnormal protein accumulation and inclusion body formation inside and outside the central nervous system. 
 Question: Which is the primary protein component of Lewy bodies?

Answer: αsyn


Question: Context: The CRISPR/Cas system in prokaryotes provides resistance against invading viruses and plasmids. Three distinct stages in the mechanism can be recognized. Initially, fragments of invader DNA are integrated as new spacers into the repetitive CRISPR locus. Subsequently, the CRISPR is transcribed and the transcript is cleaved by a Cas protein within the repeats, generating short RNAs (crRNAs) that contain the spacer sequence. Finally, crRNAs guide the Cas protein machinery to a complementary invader target, either DNA or RNA, resulting in inhibition of virus or plasmid proliferation. In this article, we discuss our current understanding of this fascinating adaptive and heritable defense system, and describe functional similarities and differences with RNAi in eukaryotes. 
 Question: Gene silencing can be achieved by RNA interference (RNAi) in eukaryotic organisms. What is the name of the analogous process in prokaryotic organisms?

Answer:
crispr-cas