In this task, you are given a sentence. You are expected to recognize the name of gene or protein. Although there might be several correct answers, you need to write one of them.

Input: Consider Input:  This effect was completely reversed by preincubation with a tyrosine phosphatase inhibitor ( Na3VO4 ) , which suggests that TGF - beta1 activated a phosphatase .

Output: TGF - beta1


Input: Consider Input:  The effects of PI3K inhibition were reversed by the ectopic expression of constitutively activated Akt - 1 or Bcl - x ( L ) .

Output: Akt - 1


Input: Consider Input:  In this study , we examined whether PPARgamma ligand regulates osteopontin gene expression in THP - 1 cells , a cell line derived from human monocytic leukemia cells which can differentiate to macrophage upon stimulation with phorbol ester PMA .


Output: PPARgamma ligand