In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Input: Consider Input: A series of 4-aminoquinoline derivatives were synthesized by the reaction of 4-chloro-7-substituted-quinolines with the corresponding mono/ dialkyl amines. The structures of the synthesized compounds were confirmed by NMR and FAB-MS spectral and elemental analyses. Subsequently, the compounds were examined for their cytotoxic effects on two different human breast tumor cell lines: MCF7 and MDA-MB468. Although all compounds examined were quite effective on both cell lines, the compound N 0 -(7-chloro-quinolin-4-yl)-N,N-dimethyl-ethane-1,2-diamine emerged as the most active compound of the series. It was particularly potent against MDA-MB 468 cells when compared to chloroquine and amodiaquine. The compound butyl-(7-fluoro-quinolin-4-yl)-amine showed more potent effects on MCF-7 cells when compared to chloroquine. Therefore, 4-aminoquinoline can serve as the prototype molecule for further development of a new class of anticancer agents.

Output: Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives


Input: Consider Input: Ten strains of avian infectious bronchitis virus (IBV) were titrated as plaqueforming units in primary chick embryo fibroblast cells. In the absence of trypsin, plaques were only formed by Beaudette-42 and Iowa-609 strains. When trypsin was incorporated in the overlay medium of cell monolayers, all the IBV strains tested produced plaques within 4days after inoculation. Incorporation of 20--40 ~xg of trypsin per ml of the overlay medium seemed to be suitable for plaque formation of IBV. A preliminary investigation was made of the mode of action of trypsin.

Output: Archives of Virology Plaque Formation by Avian Infectious Bronehitis Virus in Primary Chick Embryo Fibroblast Cells in the Presence of Trypsin


Input: Consider Input: publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. Viral infections in solid transplant patients p M DHPG combinated with 5 U / d IFN (Y and 95 f 5% inhibition with 1 l . l p M DHPG in combination with 0.2 ng/d IFN y (n = 3). Conclusions: IFN (Y and IFN y decrease HCMV infection in monocytic-like cell line THP-1 and may lead to an improvement of the available chemotherapy against this important human pathogen. Combination of IFNs with DHPG after lnfection showed a synergistic effect. PCV has a well-documented inhibitory activity against herpes simplex virus and varicelia-zoster virus. By contrast, data on its activity against CMV are limited. We evaluated the in vim activity of PCV against 3 CMV WS (#1 and #2 from marmw transplant recipients, #3 from a neonate) and against CMV strain AD169, and compared the results with those obtained in parallel with acyclovir (ACV), ganciclovir (GCV), and foscarnet (FOS). A plaque reduction assay was used to determine the mhibitory drug concentration reducing plaque numbers by 50% (IC50). The drugs were tested in 6 human fibroblast cell lines. The results were as follows: Median ICsg of 13 p M (630) indxatmg a rerkunce to ganclclovlr.


Output: I P103q Activity of Penciclovir (PCV) in vitro against Cytomegalovirus (CMV) Wild Strains (WS) and against Strain AD169