Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Ex Input:
Context: A joint is a point at which two or more bones meet. There are three main types of joints in the body: 1. Fixed joints do not allow any bone movement. Many of the joints in your skull are fixed ( Figure 1.1). There are eight bones that fuse together to form the cranium. The joints between these bones do not allow movement, which helps protect the brain. 2. Partly movable joints allow only a little movement. Your backbone has partly movable joints between the vertebrae ( Figure 1.2). The skull has fixed joints. Fixed joints do not allow any movement of the bones, which protects the brain from injury. 3. Movable joints allow the most movement. Movable joints are also the most common type of joint in your body. Your fingers, toes, hips, elbows, and knees all provide examples of movable joints. The surfaces of bones at movable joints are covered with a smooth layer of cartilage. The cartilage reduces friction between the bones. Ligaments often cross a joint, holding two nones together. For example, there are numerous ligaments connecting the leg bones across the knee joint. Four types of movable joints are discussed here. 1. In a ball-and-socket joint, the ball-shaped surface of one bone fits into the cup-like shape of another. Exam- ples of a ball-and-socket joint include the hip ( Figure 1.3) and the shoulder. 2. In a hinge joint, the ends of the bones are shaped in a way that allows motion in two directions, forward and backward. Examples of hinge joints are the knees ( Figure 1.4) and elbows. 3. The pivot joint ( Figure 1.5) only allows rotating movement. An example of a pivot joint is the joint between the radius and ulna that allows you to turn the palm of your hand up and down. 4. A gliding joint is a joint which allows only gliding movement. The gliding joint allows one bone to slide over the other. The gliding joint in your wrist allows you to flex your wrist. It also allows you to make very small side-to-side motions. There are also gliding joints in your ankles. 
 Question: what type of joint allows you to turn the palm of your hand?

Ex Output:
a pivot joint


Ex Input:
Context: Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy. We enrolled 457 patients who had active rheumatoid arthritis despite long-term methotrexate therapy in a 6-month, double-blind, placebo-controlled trial. The primary outcome was the American College of Rheumatology (ACR) 20 response (which indicates at least a 20% reduction in the number of both tender and swollen joints and improvement in at least three of five other criteria) at month 6. R788, at a dose of 100 mg twice daily and at a dose of 150 mg once daily, was significantly superior to placebo at month 6 (ACR 20 response rates of 67% and 57%, respectively, vs. 35%; P<0.001 for the comparison of both doses with placebo). It was also significantly superior with respect to ACR 50, which indicates at least a 50% improvement (43% and 32% vs. 19%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.007 for the comparison of the 150-mg dose with placebo) and ACR 70 (28% and 14% vs. 10%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.34 for the comparison of the 150-mg dose with placebo). A clinically significant effect was noted by the end of the first week of treatment. Adverse effects included diarrhea (in 19% of subjects taking the 100-mg dose of R788 vs. 3% of those taking placebo), upper respiratory infections (14% vs. 7%), and neutropenia (6% vs. 1%). R788 was associated with an increase in systolic blood pressure of approximately 3 mm Hg between baseline and month 1, as compared with a decrease of 2 mm Hg with placebo; 23% of the patients taking R788 vs. 7% of the patients receiving placebo required the initiation of or a change in antihypertensive therapy. In this phase 2 study, a Syk inhibitor reduced disease activity in patients with rheumatoid arthritis; adverse events included diarrhea, hypertension, and neutropenia. Additional studies will be needed to further assess the safety and efficacy of Syk-inhibition therapy in patients with rheumatoid arthritis. (Funded by Rigel; ClinicalTrials.gov number, NCT00665925.) 
 Question: Which enzyme is inhibited by a drug fostamatinib?

Ex Output:
spleen tyrosine kinase


Ex Input:
Context: Very Rev. Tadeusz Brzozowski, S.J. (October 21, 1749 -- February 5, 1820) was a Polish Jesuit, elected 19th Superior General of the Society of Jesus. 
 Question: What group was Tadeusz Brzozowski a member of?

Ex Output:

society of jesus