In this task you will be given a text passage from a trivia quiz. You should choose the category this question belongs to from these categories: History, Science, Social Science, Fine Arts, Literature. You can only choose one category, so if in doubt, please choose the closest match.

Imetelstat, a potential new cancer therapy agent, works by targeting the enzyme that repairs these   structures. Blackburn, Greider, and Szostak received the 2009 Nobel Prize for determining the role of  these structures, which typically adopt a G-quadruplex shape. The shortening of these structures   explains the Hayflick limit to cell division and is the basis for the cellular theory of aging, and that  shortening of these structures can lead to cell senescence or apoptosis. Consisting of thousands of  TTAGGG repeats in humans, name these end sequences of chromosomes that prevent genes from  being lost during DNA replication.
Science

The title character becomes engaged to two women and invites them both to lunch. This novel begins in Elk Hills, where the title character grows up under the tutelage of Doc Vickerson. While a research fellow at the McGurk Institute, the title character discovers the X Principle that might prove a cure for disease, though he learns it was already discovered at the Pasteur Institute. Mentors in this novel include Max Gottlieb and Gustave Sondelius, and the title character's wife Leora dies from the plague on the island of St. Hubert. FTP, identify this novel about a research scientist by Sinclair Lewis.
Literature

This disaster was aggravated by Thomas Bloodworth's failure to respond quickly, and due to an ongoing war, lynching of French and Dutch residents was common during it A plague was recorded alongside this event by Samuel Pepys ("Peeps") and this disaster was reported to have begun in Thomas Farriner's bakery on [*] Pudding Lane.This event was commemorated by a large Doric column known simply as "The Monument," and after this event, Sir Christopher Wren reconstructed St. Paul's Cathedral. For 10 points, name this September 1666 conflagration that destroyed the capital of England.

Literature