Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Q: A young patient experienced marked sinus tachycardia while smoking marijuana and receiving therapeutic doses of nortriptyline.

A: adverse drug event
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Q: Response of a promethazine-induced coma to flumazenil.

A: adverse drug event
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Q: These findings, together with increased urinary copper excretion and the absence of clinical improvement, are compatible with a generalized defect in copper metabolism, transport or storage.

A:
non-adverse drug event
****