Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein tau. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds tau with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the tau-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10(-9) M MAP2c and 10(-8) M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and tau might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease.

Output: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?


Input: Consider Input: Elis Stromgren's son was the astronomer Bengt Stromgren, who succeeded his father in Copenhagen in 1940.

Output: Who is the offspring of Elis Strömgren?


Input: Consider Input: Riociguat (Adempas): a novel agent for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.


Output: What is generic name of drug Adempas?