Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Q: Context: Schimke immuno-osseous dysplasia (OMIM 242900) is an uncommon autosomal-recessive multisystem disease caused by mutations in SMARCAL1 (swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1), a gene encoding a putative chromatin remodeling protein. Neurologic manifestations identified to date relate to enhanced atherosclerosis and cerebrovascular disease. Based on a clinical survey, we determined that half of Schimke immuno-osseous dysplasia patients have a small head circumference, and 15% have social, language, motor, or cognitive abnormalities. Postmortem examination of 2 Schimke immuno-osseous dysplasia patients showed low brain weights and subtle brain histologic abnormalities suggestive of perturbed neuron-glial migration such as heterotopia, irregular cortical thickness, incomplete gyral formation, and poor definition of cortical layers. We found that SMARCAL1 is highly expressed in the developing and adult mouse and human brain, including neural precursors and neuronal lineage cells. These observations suggest that SMARCAL1 deficiency may influence brain development and function in addition to its previously recognized effect on cerebral circulation. 
 Question: Mutations in which gene cause Schimke immune-osseous dysplasia?

A: harp
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Q: Context: Miles Monroe (Woody Allen), a jazz musician and owner of the "Happy Carrot" health-food store in 1973, is subjected to cryopreservation without his consent, and not revived for 200 years.[2] The scientists who revive him are members of a rebellion: 22nd-century America seems to be a police state, ruled by a dictator about to implement a secret plan known as the "Aries Project". The rebels hope to use Miles as a spy to infiltrate the Aries Project, because he is the only member of this society without a known biometric identity. The authorities discover the scientists' project, and arrest them. Miles escapes by disguising himself as a robot, and goes to work as a butler in the house of socialite Luna Schlosser (Diane Keaton). When Luna decides to have his head replaced with something more "aesthetically pleasing," Miles reveals his true identity to her, whereupon Luna threatens to give Miles to the authorities. In response, he kidnaps her and goes on the run, searching for the Aries Project. Miles and Luna fall in love, but Miles is captured and brainwashed into becoming a complacent member of the society, while Luna joins the rebellion. The rebels kidnap Miles and perform reverse-brainwashing, whereupon he remembers his past and joins their efforts. Miles becomes jealous when he catches Luna kissing the rebel leader, Erno Windt (John Beck), and she tells him that she believes in free love. Miles and Luna infiltrate the Aries Project, wherein they quickly learn that the national leader had been killed by a rebel bomb ten months previously. All that survives is his nose. Other members of the Aries Project, mistaking Miles and Luna for doctors, expect them to clone the leader from this single remaining part. Miles steals the nose and "assassinates" it by dropping it in the path of a road roller. After escaping, Miles and Luna debate their future together. He tells her that Erno will inevitably become as corrupt as the Leader. Miles and Luna confess their love for one another, but she claims that science has proven men and women cannot have meaningful relationships due to chemical incompatibilities. Miles dismisses this, saying that he does not believe in science, and Luna points out that he does not believe in God or political systems either. Luna asks Miles if there is anything he does believe in, and he responds with the line, "Sex and deathtwo things that come once in a lifetimebut at least after death you're not nauseous."[3] The film ends as the two embrace. 
 Question: Who catches onto the scientists' project?

A: the police or the authorities
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Q: Context: DNA must replicate (copy) itself so that each resulting cell after mitosis and cell division has the same DNA as the parent cell. All these cells, the parent cell and the two new daughter cells, are genetically identical. DNA replication occurs during the S phase (the Synthesis phase) of the cell cycle, before mitosis and cell division. The base pairing rules are crucial for the process of replication. DNA replication occurs when DNA is copied to form an identical molecule of DNA. The general steps involved in DNA replication are as follows: 1. The DNA helix unwinds like a zipper as the bonds between the base pairs are broken. The enzyme DNA Helicase is involved in breaking these bonds. 2. The two single strands of DNA then each serve as a template for a new stand to be created. Using DNA as a template means that on the new strand, the bases are placed in the correct order because of the base pairing rules. Recall that A and T are complementary bases, as are G and C. As a template strand is read, the new strand is created. If ATGCCA is on the "template strand," then TACGGT will be on the new DNA strand. The enzyme DNA Polymerase reads the template and builds the new strand of DNA. 3. The new set of nucleotides then join together to form a new strand of DNA. The process results in two DNA molecules, each with one old strand and one new strand of DNA. This process is known as semiconservative replication because one strand is conserved (kept the same) in each new DNA molecule ( Figure 1.1). DNA replication occurs when the DNA strands unzip, and the original strands of DNA serve as a template for new nucleotides to join and form a new strand. 
 Question: what is the first step in dna replication?

A:
the dna helix unwinds like a zipper.
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