Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy. We enrolled 457 patients who had active rheumatoid arthritis despite long-term methotrexate therapy in a 6-month, double-blind, placebo-controlled trial. The primary outcome was the American College of Rheumatology (ACR) 20 response (which indicates at least a 20% reduction in the number of both tender and swollen joints and improvement in at least three of five other criteria) at month 6. R788, at a dose of 100 mg twice daily and at a dose of 150 mg once daily, was significantly superior to placebo at month 6 (ACR 20 response rates of 67% and 57%, respectively, vs. 35%; P<0.001 for the comparison of both doses with placebo). It was also significantly superior with respect to ACR 50, which indicates at least a 50% improvement (43% and 32% vs. 19%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.007 for the comparison of the 150-mg dose with placebo) and ACR 70 (28% and 14% vs. 10%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.34 for the comparison of the 150-mg dose with placebo). A clinically significant effect was noted by the end of the first week of treatment. Adverse effects included diarrhea (in 19% of subjects taking the 100-mg dose of R788 vs. 3% of those taking placebo), upper respiratory infections (14% vs. 7%), and neutropenia (6% vs. 1%). R788 was associated with an increase in systolic blood pressure of approximately 3 mm Hg between baseline and month 1, as compared with a decrease of 2 mm Hg with placebo; 23% of the patients taking R788 vs. 7% of the patients receiving placebo required the initiation of or a change in antihypertensive therapy. In this phase 2 study, a Syk inhibitor reduced disease activity in patients with rheumatoid arthritis; adverse events included diarrhea, hypertension, and neutropenia. Additional studies will be needed to further assess the safety and efficacy of Syk-inhibition therapy in patients with rheumatoid arthritis. (Funded by Rigel; ClinicalTrials.gov number, NCT00665925.) 
 Question: Which enzyme is inhibited by a drug fostamatinib?
spleen tyrosine kinase

Context: The actions of benzodiazepines are due to the potentiation of the neural inhibition that is mediated by gamma-aminobutyric acid (GABA). Practically all effects of the benzodiazepines result from their actions on the ionotropic GABA(A) receptors in the central nervous system. Benzodiazepines do not activate GABA(A) receptors directly but they require GABA. The main effects of benzodiazepines are sedation, hypnosis, decreased anxiety, anterograde amnesia, centrally mediated muscle relaxation and anti-convulsant activity. In addition to their action on the central nervous system, benzodiazepines have a dose-dependent ventilatory depressant effect and they also cause a modest reduction in arterial blood pressure and an increase in heart rate as a result of a decrease of systemic vascular resistance. The four benzodiazepines, widely used in clinical anaesthesia, are the agonists midazolam, diazepam and lorazepam and the antagonist flumazenil. Midazolam, diazepam and flumazenil are metabolized by cytochrome P450 (CYP) enzymes and by glucuronide conjugation whereas lorazepam directly undergoes glucuronide conjugation. CYP3A4 is important in the biotransformation of both midazolam and diazepam. CYP2C19 is important in the biotransformation of diazepam. Liver and renal dysfunction have only a minor effect on the pharmacokinetics of lorazepam but they slow down the elimination of the other benzodiazepines used in clinical anaesthesia. The duration of action of all benzodiazepines is strongly dependent on the duration of their administration. Based on clinical studies and computer simulations, midazolam has the shortest recovery profile followed by lorazepam and diazepam. Being metabolized by CYP enzymes, midazolam and diazepam have many clinically significant interactions with inhibitors and inducers of CYP3A4 and 2C19. In addition to pharmacokinetic interactions, benzodiazepines have synergistic interactions with other hypnotics and opioids. Midazolam, diazepam and lorazepam are widely used for sedation and to some extent also for induction and maintenance of anaesthesia. Flumazenil is very useful in reversing benzodiazepine-induced sedation as well as to diagnose or treat benzodiazepine overdose. 
 Question: Which drug should be used as an antidote in benzodiazepine overdose?
flumazenil

Context: Even while in a deep sleep, people can still learn brand new information. Sleepers soak in new associations between smells and sounds, knowledge that lingers into the next waking day, researchers report online August 26 in Nature Neuroscience. The new study is the first to show that entirely new information can get into the sleeping mind, says Anat Arzi of the Weizmann Institute of Science in Israel. "The brain is not passive while you sleep. It's quite active. You can do quite a lot of things while you are asleep." But the results don't mean that Spanish vocabulary tapes now have a place on the nightstand. L, Researchers have tried but largely failed to find evidence that complicated information, such as new pairs of words, can make its way into the brain during sleep. Instead of trying to teach people something complicated like a new language, Arzi and her colleagues relied on the sense of smell and hearing. As anyone who has walked by a dumpster in July knows, smells can cause a nose-jerk reaction. Catching a bad smell automatically makes people inhale less, reducing the size of the inhale. But scent of fresh bread causes a long, deep inhale., rzi and her team took advantage of this reaction for their experiment. As people slept in the laboratory, the researchers delivered pleasant scent, such as shampoo. As this nice smell got into the sleepers' noses, the researchers played a particular music. Later, a disgusting smell, such as rotten fish or meat, was paired with a different music. Neither the smell nor the sound woke people up. After just four exposures to the smell-music pair during a single night, the sleepers started to automatically respond to the tones without the accompanying smells, taking in bigger breaths when the shampoo-associated tone played and smaller breaths when played the sound linked to the rotten fish smell. This new learned association lingered into the next waking day, too. Even though the sleepers had no idea they had been exposed to smells or sounds, their behavior proved that their brain had actually learned something during sleep. As before, the shampoo sound stimulated a long, deep inhale, while the rotten fish tone caused more shallow breaths. 
 Question: In which part of a website may this passage most likely appear?

science.