Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: Imatinib mesylate is a new drug that can inhibit the tyrosine kinase activity of Bcr-Abl, the receptors for platelet-derived growth factor receptor(PDGF) and stem cell factor, or c-kit. Chronic myeloid leukemia (CML) is distinguished by the presence of a reciprocal translocation between chromosomes 9 and 22 that results in a shortened chromosome 22, termed the Philadelphia(Ph) chromosome. As a result of the translocation, a fusion gene called the Bcr-Abl gene is created from two normal cellular genes, encoding a chimeric Bcr-Abl protein with a deregulated tyrosine kinase activity. The expression of Bcr-Abl tyrosine kinase has been shown to be necessary and sufficient for the transformed phenotype of CML cells. Imatinib can block the kinase activity of Bcr-Abl, thus inhibiting the proliferation of Ph-positive progenitors, and has shown activity against all phases of CML, though responses are most substantial and durable in patients in the chronic phase. An international phase III study which compared the efficacy of imatinib with that of interferon alpha combined with low-dose cytarabine in newly diagnosed chronic-phase CML showed the rate of major cytogenetic response at 24 months was 90%, including 82% of complete cytogenetic response. These results indicated that imatinib was superior to interferon-containing treatment as a first-line therapy. More than 10,000 patients worldwide, including those in Japan, have been treated with imatinib in clinical trials, and a lot of information has been accumulated on the use of this drug. The aim of this article is to review the use of this drug and the practical management of patients with chronic myeloid leukemia.

Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Input: Consider Input: The Raytown Branch of Mid-Continent Public Library is offering the following activities for the month of March. The library is located at 6131 Raytown Road. All activities are free, but registration is required. Tax Help for Seniors 10 a.m. Mondays and Wednesdays. AARP Tax-Aide representatives will be at the Library to assist seniors with medium to low incomes with tax questions and free tax return preparation. Time listed indicates starting time. Teen Games 2 p.m. March 2. Challenge yourself, challenge your friends. Movie Classics For adults, 2 p.m. March 4. Join us for an afternoon of nostalgia as we watch classic films. Call to see what's showing. KC Zoomobile Africa, for ages 5 and older, 11 a.m. March 5. Join the Kansas City Zoo for an African adventure. We will share African culture as well as show you an animal or two. Come with us to learn something new about Africa. Kids at the Library For ages 6 and older, 11 a.m. March 12. Discover, create, and play. Explore big ideas in a new way. Chess Free Play For ages 6 and older, 1 p.m. March 12. Play chess, learn the basics, brush up on your chess skills, challenge other players at Free Chess Play at the library. The Raytown Branch, in cooperation with the Raytown High School Chess Team coaches, will be hosting chess on the second Saturday of the month from 1 to 3 p.m. Chess boards and chess pieces will be provided. Eggstravaganza Noon March 26. Join us for story time with Mayor Mike McDonough, as we take part in Raytown's Easter festivities. After the stories, the Easter Bunny will escort the children across the street for an Easter egg hunt.

Output: Which activity is more likely to develop imagination and creativity?


Input: Consider Input: Thomas W. Meaux is a former member of the Wisconsin State Assembly.


Output: What is the position of Thomas W. Meaux?