Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Freshwater below Earths surface is called groundwater. The water infiltrates, or seeps down into, the ground from the surface. How does this happen? And where does the water go? Water infiltrates the ground because soil and rock are porous. Between the grains are pores, or tiny holes. Since water can move through this rock it is permeable. Eventually, the water reaches a layer of rock that is not porous and so is impermeable. Water stops moving downward when it reaches this layer of rock. Look at the diagram in Figure 13.11. It shows two layers of porous rock. The top layer is not saturated; it is not full of water. The next layer is saturated. The water in this layer has nowhere else to go. It cannot seep any deeper into the ground because the rock below it is impermeable. The top of the saturated rock layer in Figure 13.11 is called the water table. The water table isnt like a real table. It doesnt remain firmly in one place. Instead, it rises or falls, depending on how much water seeps down from the surface. The water table is higher when there is a lot of rain and lower when the weather is dry. An underground layer of rock that is saturated with groundwater is called an aquifer. A diagram of an aquifer is shown in Figure 13.12. Aquifers are generally found in porous rock, such as sandstone. Water infiltrates the aquifer from the surface. The water that enters the aquifer is called recharge. Most land areas have aquifers beneath them. Many aquifers are used by people for freshwater. The closer to the surface an aquifer is, the easier it is to get the water. However, an aquifer close to the surface is also more likely to become polluted. Pollutants can seep down through porous rock in recharge water. An aquifer that is used by people may not be recharged as quickly as its water is removed. The water table may lower and the aquifer may even run dry. If this happens, the ground above the aquifer may sink. This is likely to damage any homes or other structures built above the aquifer. One of the biggest aquifers in the world is the Ogallala aquifer. As you can see from Figure 13.13, this aquifer lies beneath parts of eight U.S. states. It covers a total area of 451,000 square kilometers (174,000 square miles). In some places, it is less than a meter deep. In other places, it is hundreds of meters deep. The Ogallala aquifer is an important source of freshwater in the American Midwest. This is a major farming area, and much of the water is used to irrigate crops. The water in this aquifer is being used up ten times faster than it is recharged. If this continues, what might happen to the Ogallala aquifer? The top of an aquifer may be high enough in some places to meet the surface of the ground. This often happens on a slope. The water flows out of the ground and creates a spring. A spring may be just a tiny trickle, or it may be a big gush of water. One of the largest springs in the world is Big Spring in Missouri, seen in Figure 13.14. Water flowing out of the ground at a spring may flow downhill and enter a stream. Thats what happens to the water that flows out of Big Spring in Missouri. If the water from a spring cant flow downhill, it may spread out to form a pond or lake instead. Lake George in New York State, which is pictured in Figure 13.15, is a spring-fed lake. The lake basin was carved by a glacier. Some springs have water that contains minerals. Groundwater dissolves minerals out of the rock as it seeps through the pores. The water in some springs is hot because it is heated by hot magma. Many hot springs are also mineral springs. Thats because hot water can dissolve more minerals than cold water. Grand Prismatic Spring, shown in Figure 13.16, is a hot mineral spring. Dissolved minerals give its water a bright blue color. The edge of the spring is
top of an underground rock layer that is saturated with water

Daniel Caligiuri (pronounced (kaliduri); born 15 January 1988 in Villingen-Schwenningen) is a German-born Italian professional footballer who plays as a midfielder for VfL Wolfsburg in the Bundesliga and the Italy national team.
What position was played by Daniel Caligiuri?

Using post-embedding immunogold electron microscopy, TAR DNA-binding protein of 43 kDa (TDP-43) was localized to neuronal cytoplasmic (NCI) and intranuclear (NII) inclusions, as well as unmyelinated neurites, in frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U), amyotrophic lateral sclerosis (ALS), Alzheimer's (AD), Pick's disease (PiD) and Lewy body disease (LBD). The TDP-43 immunoreactive structures were morphologically heterogeneous. The most common was characterized by bundles of 10-20 nm diameter straight filaments with electron dense granular material within NCI, NII and neurites. This type of pathology was found in FTLD-U, ALS and some cases of AD. Less often, inclusions in neuritic processes of FTLD-U and some cases of AD contained 10-17 nm diameter straight filaments without granular material. A final type of TDP-43 immunoreactivity was labeling of filaments and granular material associated with tau filaments in neurofibrillary tangles of AD and Pick bodies of PiD or alpha-synuclein filaments in Lewy bodies of LBD. The results suggest that TDP-43 is the primary component of the granulofilamentous inclusions in FTLD-U and ALS. Similar inclusions sometimes accompany filamentous aggregates composed of other abnormal proteins in AD, PiD and LBD.

Which is the primary protein component of Lewy bodies?