Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: One day, a slave owner entered a local store and threatened a young boy who was his slave. At first, the slave refused to move and ran for the door. The slave owner reached for a heavy weight. He threw it at his slave. Instead, it hit Harriet on the head. Harriet almost died. For the rest of her life, she carried the mark of a deep wound on her head. Miser Brodas felt he never needed Harriet. He decided to sell her. Harriet thought of a way to prevent this. Each time she was shown to someone who might buy her, she acted as if she were falling asleep. After a while, Mister Brodas gave up the hope of selling Harriet. He sent her back to the fields. At 24 she married a free black man, John Tubman. By then, Harriet was sure she should escape. In 1849, Mister Brodas died. His slaves probably would be sold to further South. John Tubman tried to make Harriet forget about running away. Harriet decided she must end her marriage and that she needed to tell her family that she was leaving. Harriet escaped for Pennsylvania where slavery was banned there. Once she hid under hay that had been cut from the fields. Another time, she wore men's clothing. Finally, she arrived in Pennsylvania. Now that Harriet was free, she didn't forget other slaves in Maryland. During the next ten years, she freed her parents and other family members. She traveled back and forth eighteen times, helping about 300 slaves escape. She became an expert at hiding from slave hunters. At one time, anyone finding Harriet was promised 40,000dollars for catching her--dead or alive. The people she helped called her Moses. She had rescued them from slavery just as the biblical Moses rescued the Jews. After the Civil War began, Harriet started to spy for the North. She also served as a nurse. After four years of bloody fighting, the North won the war. Abraham Lincoln freed the slaves in 1863. There was no longer any need for Harriet to be Moses.

Output: We know from the passage that Harriet was Mister Brodas'    .


Input: Consider Input: Urgent surgery or life-threatening bleeding requires prompt reversal of the anticoagulant effects of dabigatran. This study assessed the ability of three- and four-factor prothrombin complex concentrate (PCC) and idarucizumab (specific antidote for dabigatran) to reverse the anticoagulant effects of dabigatran in a porcine model of trauma. Twelve animals were given dabigatran etexilate (DE) orally and dabigatran intravenously, before infliction of trauma. Six animals received tranexamic acid plus fibrinogen concentrate 12 minutes post-injury. Six PCCs (each 30 and 60 U/kg) and idarucizumab (30 and 60 mg/kg) were added to blood samples ex vivo. Coagulation was assessed by several coagulation assays. All coagulation parameters were altered after dabigatran infusion (plasma level: 442 138 ng/ml). Both three- and four-factor PCCs mostly or completely reversed the effects of dabigatran on thromboelastometry variables and PT but not on aPTT. Idarucizumab neutralised plasma concentrations of dabigatran, and reversed the effects of the drug on coagulation variables. Thrombin generation showed dose-dependent over-correction following the addition of PCC, implying that elevated levels of thrombin are required to overcome dabigatran-induced coagulopathy. In contrast, treatment with idarucizumab returned thrombin generation to baseline levels. Following trauma, therapy with tranexamic acid plus fibrinogen improved correction of coagulation parameters by PCC, and thromboelastometry parameters by idarucizumab. All investigated PCCs improved dabigatran- and trauma-induced coagulopathy to a similar degree. In conclusion, this study shows that three- and four-factor PCCs are similarly effective for dabigatran reversal. Idarucizumab also reversed the effects of dabigatran and, unlike PCCs, was not associated with over-correction of thrombin generation.

Output: Which drug can be reversed with idarucizumab?


Input: Consider Input: To compare tumor control rates after surgical resection or stereotactic radiosurgery for patients with small- to medium-size intracranial meningiomas. Between 1990 and 1997, 198 adult meningioma patients treated at our center underwent either surgical resection (n = 136) or radiosurgery (n = 62) as primary management for benign meningiomas <35 mm in average diameter. Tumor recurrence or progression rates were calculated by the Kaplan-Meier method according to an independent radiographic review. The mean follow-up was 64 months. The tumor resections were Simpson Grade 1 in 57 (42%), Grade 2 in 57 (42%), and Grade 3-4 in 22 (16%). The mean margin and maximal radiation dose at radiosurgery was 17.7 Gy and 34.9 Gy, respectively. Tumor recurrence/progression was more frequent in the surgical resection group (12%) than in the radiosurgical group (2%; p = 0.04). No statistically significant difference was detected in the 3- and 7-year actuarial progression-free survival (PFS) rate between patients with Simpson Grade 1 resections (100% and 96%, respectively) and patients who underwent radiosurgery (100% and 95%, respectively; p = 0.94). Radiosurgery provided a higher PFS rate compared with patients with Simpson Grade 2 (3- and 7-year PFS rate, 91% and 82%, respectively; p <0.05) and Grade 3-4 (3- and 7-year PFS rate, 68% and 34%, respectively; p <0.001) resections. Subsequent tumor treatments were more common after surgical resection (15% vs. 3%, p = 0.02). Complications occurred in 10% of patients after radiosurgery compared with 22% of patients after surgical resection (p = 0.06). The PFS rate after radiosurgery was equivalent to that after resection of a Simpson Grade 1 tumor and was superior to Grade 2 and 3-4 resections in our study. If long-term follow-up confirms the high tumor control rate and low morbidity of radiosurgery, this technique will likely become the preferred treatment for most patients with small- to moderate-size meningiomas without symptomatic mass effect.


Output: Simpson grading is used to describe resection of which brain tumor?