Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: Empagliflozin is an orally available, potent and highly selective inhibitor of the sodium glucose cotransporter 2 (SGLT2). This study was undertaken to investigate the effect of food on the pharmacokinetics of 25 mg empagliflozin and to assess dose proportionality between 10 mg and 25 mg empagliflozin under fasted conditions. In this open-label, 3-way, cross-over study, 18 healthy volunteers received 3 single doses of empagliflozin in a randomized sequence (25 mg empagliflozin under fasted conditions, 25 mg empagliflozin after a high-fat, high-calorie breakfast and 10 mg empagliflozin under fasted conditions), each separated by a washout period of at least 7 days. Serial plasma samples were collected at selected time points over a period of 72 hours. Administration with food had no clinically relevant effect on the area under the plasma concentration-time curve (AUC0-) of empagliflozin (geometric mean ratio (GMR): 84.04, 90% confidence interval (CI): 80.86 - 87.34). The decrease observed in the maximum plasma concentrations (Cmax) of empagliflozin (GMR: 63.22, 90% CI: 56.74 - 70.44) when administered with food was not considered clinically meaningful. The increases in AUC0- and Cmax for 10 mg vs. 25 mg empagliflozin administered under fasting conditions were roughly dose-proportional, as demonstrated by the slope of the regression lines being slightly less than 1 (slope for AUC0-: 0.94, 95% CI: 0.90 - 0.97; slope for Cmax: 0.91, 95% CI: 0.80 - 1.01). Empagliflozin was well tolerated under fed and fasting conditions. The results support administration of empagliflozin tablets independently of food. Increases in empagliflozin exposure under fasting conditions were roughly dose-proportional between 10 mg and 25 mg empagliflozin.

A: Which protein does empagliflozin inhibit?
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Q: Ring finger protein 5 pseudogene 1, also known as RNF5P1, is a human gene.

A: In what living being can RNF5P1 be found?
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Q: The War of Jenkins' Ear was a conflict between Britain and Spain lasting from 1739 to 1748, with major operations largely ended by 1742. Its unusual name, coined by Thomas Carlyle in 1858, refers to an ear severed from Robert Jenkins, a captain of a British merchant ship. There is no evidence of the stories that the severed ear was exhibited before the British Parliament. The seeds of conflict began with the separation of an ear from Jenkins following the boarding of his vessel by Spanish coast guards in 1731, eight years before the war began. Popular response to the incident was tepid until several years later when opposition politicians and the British South Sea Company hoped to spur outrage against Spain, believing that a victorious war would improve Britain's trading opportunities in the Caribbean. Also ostensibly providing the impetus to war against the Spanish Empire was a desire to pressure the Spanish not to renege on the lucrative asiento contract, which gave British slavers permission to sell slaves in Spanish America. The war resulted in heavy British casualties in North America. After 1742, the war was subsumed by the wider War of the Austrian Succession, which involved most of the powers of Europe. Peace arrived with the Treaty of Aix-la-Chapelle in 1748. From the British perspective, the war was notable because it was the first time that a regiment of colonial American troops was raised and placed "on the Establishment" - made a part of the regular British Army - and sent to fight outside North America.

A:
Of which did the asiento contract did NOT refer to, the Austrian Succession or the British slave sales in in Spanish America?
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