Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: Epigenetic modifications of histones regulate gene expression and chromatin structure. Here we show that Meisetz (meiosis-induced factor containing a PR/SET domain and zinc-finger motif) is a histone methyltransferase that is important for the progression of early meiotic prophase. Meisetz transcripts are detected only in germ cells entering meiotic prophase in female fetal gonads and in postnatal testis. Notably, Meisetz has catalytic activity for trimethylation, but not mono- or dimethylation, of lysine 4 of histone H3, and a transactivation activity that depends on its methylation activity. Mice in which the Meisetz gene is disrupted show sterility in both sexes due to severe impairment of the double-stranded break repair pathway, deficient pairing of homologous chromosomes and impaired sex body formation. In Meisetz-deficient testis, trimethylation of lysine 4 of histone H3 is attenuated and meiotic gene transcription is altered. These findings indicate that meiosis-specific epigenetic events in mammals are crucial for proper meiotic progression.
Example Output: What is the characteristic domain of histone methyltransferases?

Example Input: A cardiovascular disease (CVD) is any disease that affects the cardiovascular system. But the term is usually used to describe diseases that are linked to atherosclerosis. Atherosclerosis ( Figure 1.1) is an inflammation of the walls of arteries that causes swelling and a buildup of material called plaque. Plaque is made of cell pieces, fatty substances, calcium, and connective tissue that builds up around the area of inflammation. As a plaque grows, it stiffens and narrows the artery, which decreases the flow of blood through the artery. Atherosclerosis normally begins in late childhood and is typically found in most major arteries. It does not usually have any early symptoms. Causes of atherosclerosis include a high-fat diet, high cholesterol, smoking, obesity, and diabetes. Atherosclerosis becomes a threat to health when the plaque buildup prevents blood circulation in the heart or the brain. A blocked blood vessel in the heart can cause a heart attack. Blockage of the circulation in the brain can cause a stroke. Ways to prevent atherosclerosis include eating healthy foods, getting plenty of exercise and not smoking. These three factors are not as hard to control as you may think. If you smoke, STOP. Start a regular exercise program and watch what you eat. A diet high in saturated fat and cholesterol can raise your cholesterol levels, which makes more plaque available to line artery walls and narrow your arteries. Cholesterol and saturated fats are found mostly in animal products such Atherosclerosis is sometimes referred to as hardening of the arteries; plaque build- up decreases the blood flow through the artery. as meat, eggs, milk, and other dairy products. Check food labels to find the amount of saturated fat in a product. Also, avoid large amounts of salt and sugar. Be careful with processed foods, such as frozen dinners, as they can be high in fat, sugar, salt and cholesterol. Eat lots of fresh or frozen fruits and vegetables, smaller portions of lean meats and fish, and whole grains such as oats and whole wheat. Limit saturated fats like butter, instead choose unsaturated vegetable oils such as canola oil. Like any other muscle, your heart needs oxygen. Hearts have arteries that provide oxygen through the blood. They are known as coronary arteries. Coronary heart disease is the end result of the buildup of plaque within the walls of the coronary arteries. Coronary heart disease often does not have any symptoms. A symptom of coronary heart disease is chest pain. Occasional chest pain can happen during times of stress or physical activity. The pain of angina means the heart muscle fibers need more oxygen than they are getting. Most people with coronary heart disease often have no symptoms for many years until they have a heart attack. A heart attack happens when the blood cannot reach the heart because a blood vessel is blocked. If cardiac muscle is starved of oxygen for more than roughly five minutes, it will die. Cardiac muscle cells cannot be replaced, so once they die, they are dead forever. Coronary heart disease is the leading cause of death of adults in the United States. The image below shows the way in which a blocked coronary artery can cause a heart attack and cause part of the heart muscle to die ( Figure 1.2). Maybe one day stem cells will be used to replace dead cardiac muscle cells. Atherosclerosis in the arteries of the brain can also lead to a stroke. A stroke is a loss of brain function due to a blockage of the blood supply to the brain. Risk factors for stroke include old age, high blood pressure, having a previous stroke, diabetes, high cholesterol, and smoking. The best way to reduce the risk of stroke is to have low blood pressure.
Example Output: what is atherosclerosis?

Example Input: The Islands of Hawaii Hawaii The "Big Island" of Hawaii is a paradise playground where visitors can enjoy a popular lifestyle and at the same time, witness the attraction of nature: thousands of square miles form a wonderland, featuring breathtaking beaches, forests, snow-covered mountains and amazing active volcanoes. A visit to Volcanoes National Park, which has been described as a true wonder of the world, is a must. It is the state's biggest attraction. Accommodations Seasons Resort Hualalai from $ 205.00Fairmont Orchid: from $108.00 Sightseeing and Experiences Circle Island Tour: from $48.00 Kauai The beautiful landscape of Kauai has led to it being called the "Garden Isle", but it is also referred to as the "Island of discovery", and with good reason - a land of striking natural contrasts just waiting to be explored. Green mountains, a breathtaking coastline and white sand beaches combine to make it one of the world's most relaxing locations. Accommodations Grand Hyatt Kauai: from $ 101.00Sheraton Kauai Resort: from $ 79.00 Maui Voted the "World's Best Island", Maui is widely regarded as one of the most romantic destinations on earth. It is known as the "Valley Isle" and was the ancient playground for Hawaiian royalty. The island is largely rural with a small and wonderful population and a host of attractions and nature wonders. Accommodations Hyatt Regency Maui Resort & Spa: from $ 87.00 Sheraton Maui: from $ 99.00 Oahu Oahu has a unique rhythm, filling the air with sweet fragrances , music and language: from lovely beaches and amazing nightlife to beautiful rainforests and quiet valleys. Adventure, history, romance, discovery--Oahu waits for you. Accommodations Halekulani: from $ 121.00 Hilton Hawaiia: Village: from $ 73.00 Sightseeing and Experiences Royal Circle Island Tour: from $ 34.00 Paradise Cove Lu'au: $ 44.00 # All prices are based on per person per night.
Example Output:
Which island was the ancient playground for Hawaiian royalty?