Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: Chediak-Higashi syndrome (CHS) is a rare multiorgan disease entity with autosomal recessive inheritance characterized by oculocutaneous albinism, bleeding tendency, recurrent bacterial infections and various neurological symptoms. Intracellular vesicle formation is deficient, resulting in giant granules in many cells, e.g. giant melanosomes in the melanocytes. Diagnosis has been based on morphological examination of peripheral blood and bone marrow, with giant granules seen in cells of the myeloid lineage and in lymphocytes. The ultimate diagnostic test is to look for a mutated LYST gene. Most patients develop an accelerated phase of the disease with deposition of lymphohistiocytes in the liver, spleen, lymph nodes and bone marrow, resulting in hepatosplenomegaly, bone marrow infiltration and haemophagocytosis. Peripheral blood neutropenia becomes more profound as anaemia and thrombocytopenia develop. Most patients succumb before the age of 10 years. Four patients with CHS are described, one of whom is a long-term survivor after successful allogeneic bone marrow transplantation, two succumbed during the accelerated phase and one is living with a chronic form of the disease. Allogeneic bone marrow transplantation from an HLA-matched sibling is the therapy of choice and should be performed early. If there is no matched family donor, an unrelated donor or a placental blood graft is a good alternative. The clinical picture of CHS is heterogeneous and therapeutic decisions need to be made on an individual basis.

Output: Which mutated gene causes the Chédiak–Higashi Syndrome?


Input: Consider Input: It was a comfortable sunny Sunday. I was going to meet an old university friend I hadn't seen for years, and was really excited to hear all his news. My train was running a little late, but that was no big problem - I could text him to say I would be delayed. He would understand. But... where was my mobile phone? I had that familiar sinking feeling. Yes, I'd forgotten it at home. No mobile phone. I'm sure I'm not alone in feeling anxious, _ and worried when I don't have my phone with me. In fact, I know I'm not alone: two-thirds of us experience 'nomophobia', the fear of being out of mobile phone contact. That's according to a study from 2012 which surveyed 1,000 people in the UK about their relationship with mobile phones. It says we check our mobile phones 34 times a day, that women are more 'nomophobic'than men, and that 18-24 year-olds are the most likely to suffer fear of being without their mobiles: 77% of them say they are unable to be apart from their phones for more than a few minutes. Do you have nomophobia ? * You never turn your phone off * You obsessively check for texts, missed calls and emails* You always take your phone to the bathroom with you* You never let the battery run out It's funny to think that around 20 years ago the only people with mobile phones would be businessperson carrying their large, plastic 'bricks'. Of course, these days, mobile phones are everywhere. A UN study from this year said mobile phone subscriptions would outnumber people across the world by the end of 2014. And when there are more phones than people in the world, maybe it's time to ask who really is in charge? Are you in control of your phone, or does your phone control you? So, what happened with my university friend? When I arrived a few minutes late he just laughed and said: "You haven't changed at all - still always late!" And we had a great afternoon catching up, full of jokes and stories, with no interruptions and no nagging desire to check my phone. Not having it with me felt strangely liberating. Maybe I'll leave it at home on purpose next time.

Output: Which word is used to describe old mobile phones according to the passage?


Input: Consider Input: Saturday, October 8, 120 miles northeast of Blainsworth, Nebraska; 1:16 p.m.Bob Irisin, a metrologist for the Kansas City weather bureau, is riding in his Bronco truck when he stops and radios to his friend Stan in Kansas City, that he is witnessing a sudden change in weather patterns in the area. Then a tornado suddenly touches down near a farm where Bob sees a family of a man, woman and their little girl standing in front of the house, unaware of the tornado approaching behind them. Bob drives as near as he can go and manages to yell out a warning to the family seconds before they see the twister coming. The family runs into their storm shelter just in time before the twister destroys their house. Bob drives away from harms way just in time.Meanwhile, in Blainsworth, there is the annual fall Bike-a-thon race for the high school kids. 13-year-old Dan Hatch gets a flat tire and doesnt come in at all. Dans stern father, Jack, is arguing with a banker who's asking to foreclose on his hardware shop since a new mall has opened in the nearby town. Jack refuses to sell the shop at any price. Dan walks his bike into the town square where his best friend, Arthur, talks with him about getting "crashed and burned" during the race. Jack walks over and becomes hard on Dan for not finishing the race like a man should. Dan yells at his father for being so demanding and that he can't expect anything from anyone. Dan's mother, Laura, with her new baby Ryan and her friend Jenny, walk by and never less tell him he did okay anyway. Just then, Dan is called to the square podium for he is has been chosen by a lottery to be the winner of a new Schwinn Voyager bicycle, much to his father and mother's delight.75 miles northeast of Blainsworth; 3:37 p.m. Bob sits in his Bronco truck and radios in of rogue weather patterns, while observing another tornado rip through a nearby trailer park. Bob tells Stan that the front is moving south instead of north and the atmospheric activity is the most bizarre he has ever seen. Bob decides to travel to Blainsworth to see if anything will happen.Outside of Blainsworth, Dan and Arthur sit in the woods looking up at the clear sky. Dan tell Arthur about his fathers demanding which is a driving force that he cant stand. Then Arthur's two younger sisters, Stacey and Ronnie Vae, appear and want Arthur to come home since their parents are out of town for the weekend. Arthur and Dan watch as clouds begin to roll in and they decide to get indoors. At Arthurs house, the boys play a game of pool, in which Dan forgets he's suppose to take his grandmother's dog for a walk.Six miles northeast of Blainsworth 4:30 p.m.; Dan arrives at his grandmother Goldie's house where his father is already there taking her dog to the vet, for it has a bad leg. Jack yells at Dan for not being responsible for anything, and Dan rides on his new bike home.Arthur arrives at the Hatch house, were Laura is getting ready to leave for work for the evening. Jenny arrives at the house to pick Laura up, were they talk about Jack being so domineering on Dan for he doesn't want Dan to end up a loser like him.Nightfall. Arthur and Dan play with musical instruments, while checking every few minutes if baby Ryan in the next room is all right. Jack then arrives and tells Dan and Arthur to bring their bicycles in for its raining. Going out, they find that its raining hard and the winds are picking up speed. Arthur tells Dan that since hes originally from Los Angeles, he enjoys the rain, while Dan sees little amusement in it, for he tells Arthur that rain and hailstorms can get bad.At the local diner in town, Laura is waitressing when Bob walks in asking for some coffee. Bob overhears a farmer named Gus talk about the storm and of tornados reported in the area. Bob tells Gus that most people killed by tornados


Output: What kind of race does Jack push Danny to compete in?