Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.

Example Input: Six patients were still responding at 7.5 months of follow-up, according to research presented in San Diego at the annual meeting of the American Society of Hematology (ASH). The highest trial dose was discontinued due to toxicity. Nearly a third of trial patients developed serious infections and other side effects included nerve damage and liver failure. Amgen said AMG420, which targets a protein linked to multiple myeloma known as BCMA, has been given fast track status by the U.S. Food and Drug Administration. “Based on these data, we plan to open an expanded trial,” David Reese, Amgen’s head of research and development, said in an interview. “We want to begin exploring quickly enrollment in earlier lines of therapy.”  Amgen’s pipeline of bispecific antibodies, which are designed to attach to a cancer cell and an immune cell, bringing them together so the body’s immune system can kill the cancer, are a cornerstone of the biotech company’s oncology research. Other companies are exploring different ways to attack the same BCMA target, including bluebird bio Inc, Celgene Corp and Johnson & Johnson. Earlier at the ASH meeting, bluebird and Celgene presented early trial data showing that experimental cell therapy bb21217 induced responses in 10 out of 12 heavily pre-treated myeloma patients. Bb21217 is a next-generation version of bb2121, the companies’ more advanced, but still experimental therapy in a class called CAR-T that requires harvesting a patient’s own disease-fighting T-cells, modifying them in a laboratory so they target specific proteins on cancer cells and infusing them back into the patient. The manufacturing process for bb21217 is designed to improve the persistence of the altered cells. J&J, which licensed BCMA-directed CAR-T LCAR-B38M from a unit of China-based GenScript Biotech Corp, on Monday presented updated results from a Chinese study of the cell therapy in 57 previously treated myeloma patients. It showed that 88 percent of patients responded to the treatment, and 74 percent achieved remission. J&J is currently enrolling patients in an international study aimed at validating those findings. Amgen has suggested the “off the shelf” nature of its antibody platform could be an advantage from both a clinical and commercial standpoint, but oncologists say more data is needed. Trial patients are hospitalized for their first cycle of AMG420, after which they receive the drug by continuous 24-hour infusion for four weeks, followed by two weeks off therapy, for up to 10 cycles. Amgen has another BCMA-targeting antibody that lasts longer in the body, requiring less frequent infusions, but that research is at an earlier stage. In the current study, 42 patients with multiple myeloma that  worsened after at least two prior treatments were given AMG420 at varying doses. A total of 13 patients responded to the treatment, including seven who achieved remission. Of the 20 patients with serious adverse events, 17 required hospitalization and four had prolonged hospitalization.
Example Output: Amgen antibody shows promise in myeloma trial, gets FDA fast track.

Example Input: A skier takes a jump during sunny winter weather at the Swiss mountain area of Hoch-Ybrig, south of Zurich, February 23, 2011. REUTERS/Arnd Wiegmann Lisa Wheeler, a New York-based fitness instructor, believes it’s never too late to get in shape to make skiing more enjoyable and safe. But don’t overdo it. “Do some basic strength training for the legs, core and arms,” said Wheeler, fitness program director for DailyBurn, an online workout site. “But if you haven’t done anything, dial it back a little.”   Wheeler recommends lunges to strengthen the quadriceps, the long muscles in the front of the thigh. “Lunges are quad-dominant and skiing is very quad dominant because your knees are bent and you’re going downhill,” she said. “And lunges also work the hamstrings and glutes,” she explained, referring to the large muscles that form the buttocks. Wheeler thinks the novice can forgo jumping or hopping lunges and concentrate instead on matrix lunges, basically stepping to and pushing off different directions across the range of motion. “For the last-minute person I recommend taking it easy,” she said. Wheeler said people think of skiing as going in one direction, downhill, and neglect to prepare their hips and core for the considerable demands of the activity. “If you analyze skiing there’s a lot of rotation and lateral movement of the hips,” she said. “I would do some core exercises, such as planks, and rotational movements with the medicine ball,” she said. “Because going down the slopes your body is turning, your hips are turning.”   Jessica Matthews of the American Council on Exercises suggests exercises that mimic the activity of skiing, which along with cardiovascular fitness and muscle strength, demands a measure of speed and agility. “I’m a huge fan of cone drills,” she said. “I just picked up a set for the house.”   Sold in sporting goods stores, cones are smaller and lighter than traffic cones. Matthews, an exercise physiologist, thinks they are ideal for setting up a circuit to train for the movements of weaving down a mountain. “You can work on developing lower body strength, lateral movements, do cone jumps and practice proper landing,” she said. Squats and lunges build lower body strength but for those challenged by a full squat, Matthews suggests the wall sit, which is essentially placing the back against the wall with knees bent. Ideally, she said, you want to begin a pre-ski routine at least six weeks prior to hitting the slopes. “That’s a good time from physiological standpoint,” she said. Another crucial element to skiing is the ability to react quickly. “Downhill is not straight downhill,” said Matthews. “You have to dodge people. You’ve got to be able to make quick changes, you might have to counter a fall, so it’s important to make sure your hips, legs, shoulders, spine are all ready to go.” Wheeler said.
Example Output: Pre-ski preparations help before hitting the slopes.

Example Input: The story should have stated how much CAD costs per mammogram, and how that compares to the costs of a radiologist or technician providing a second reading of the images. The story quotes a researcher saying cost-effectiveness needs to be studied. This should have triggered additional reporting comparing costs. The story says Medicare pays $15 per CAD reading, but this does not indicate whether this covers costs. The story does a good job of describing the methodology and the outcomes in terms readers can understand. The study results showed that the recall rates–the percentage of women brought back for a second mammogram–was signficantly higher with CAD than with double readings (3.9 percent vs. 3.5 percent). Yet CAD discovered no more cancers. These additional mammograms without more accurate diagnosis can produce increased anxiety and potentially more biopsies. The report should have mentioned this. This news report is based on a peer-reviewed study published in a top-tier medical journal. The underlying study itself is a randomized, blinded trial involving about 30,000 women. The story does nothing to exaggerate either the prevalence or severity of breast cancer, or the benefits of CAD. The reporter quotes the article itself, the lead author, a breast cancer clinician at a major teaching hospital, a medical society’s breast cancer expert, and a clinician who uses CAD in his practice. This is excellent sourcing. The story reports the study’s funding, as well as two of the researchers’ links to CAD makers. The story clearly compares the options of having two human readers of mammograms against one reader using CAD. Yet the reporter fails to compare the value of these methods with those when a single human reader is used, which remains the common practice in the U.S. The study reports that double readings have been shown to be 4 to 14 percent more effective in detecting cancers than single readings, with a recent meta-analysis showing a 10 percent advantage to double reading. This context would have been very valuable, to demonstrate that U.S. diagnostic practices miss a lot of cancers. The story states that computer-aided dectection (CAD) of breast cancer is used for about a third of mammograms in the U.S. This implies availability at more specialized facilities and teaching hospitals. A more direct statement of this would have been useful. But the story meets minimum standards under this criterion. The story says CAD is used for about one-third of mammograms in the U.S. and is likely to be used more as digital imaging becomes more widespread. The report does not appear to draw on the press release.
Example Output:
Computers help docs spot breast cancer on X-rays