instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: The synthesis of racemic substituted 7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one hydrochlorides was optimized to enhance reproducibility and increase the overall yield. In order to investigate their specificity, series of enzyme inhibition assays were carried out against a diversity of proteases, covering representative members of aspartic, cysteine, metallo and serine endopeptidases and including eight members of the monometallic M1 family of aminopeptidases as well as two members of the bimetallic M17 and M28 aminopeptidase families. This aminobenzosuberone scaffold indeed demonstrated selective inhibition of M1 aminopeptidases to the exclusion of other tested protease families; it was particularly potent against mammalian APN and its bacterial/parasitic orthologues EcPepN and Pf AM1. 
 Title: molecules Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases
answer:
True


question:
Paragraph: Our ability to uncover complex network structure and dynamics from data is fundamental to understanding and controlling collective dynamics in complex systems. Despite recent progress in this area, reconstructing networks with stochastic dynamical processes from limited time series remains to be an outstanding problem. Here we develop a framework based on compressed sensing to reconstruct complex networks on which stochastic spreading dynamics take place. We apply the methodology to a large number of model and real networks, finding that a full reconstruction of inhomogeneous interactions can be achieved from small amounts of polarized (binary) data, a virtue of compressed sensing. Further, we demonstrate that a hidden source that triggers the spreading process but is externally inaccessible can be ascertained and located with high confidence in the absence of direct routes of propagation from it. Our approach thus establishes a paradigm for tracing and controlling epidemic invasion and information diffusion in complex networked systems. ½S i ðt 2 Þ þ S i ðt 6 Þ=2 and hS i ðt 2 þ 1Þi ¼ ½S i ðt 12 Þ þ S i ðt 14 Þ=2 based on the remaining strings marked in different colours (see Methods for more details). CST can be used to reconstruct the neighbouring vector X of node 2 from Y and U from Y ¼ U . X. 
 Title: ARTICLE Reconstructing propagation networks with natural diversity and identifying hidden sources
answer:
False


question:
Paragraph: A 28-nucleotide mRNA pseudoknot that overlaps the P1 and P2 genes of sugarcane yellow leaf virus (ScYLV) stimulates −1 ribosomal frameshifting. The in vitro frameshifting efficiency is decreased ≈8 fold upon substitution of the 3′ most loop 2 nucleotide (C27) to adenosine, which accepts a hydrogen bond from the 2′-OH of C14 in stem S1. The solution structures of the wild-type (WT) and the C27A ScYLV RNA pseudoknots show that while the RNAs adopt virtually identical overall structures, there are significant structural differences at the helical junctions of the two RNAs. Specifically, C8 + in loop L1 in the C8 + ·(G12-C28) L1-S2 major groove base triple is displaced by ≈2.3 Å relative to the accepting stem 2 base pair (G12-C28) in the C27A RNA. Here, we employ a double mutant cycle approach to analyze the pairwise coupling of the C8 + ·(G12-C28) and C27·(C14-G7) or A27·(C14-G7) hydrogen bonds in the WT and C27A ScYLV RNAs, respectively, and compare these findings with previous results from the beet western yellows virus (BWYV) RNA. We find that the pairwise coupling free energy (δ AB i ) is favorable for the WT RNA (-0.7 ±0.1 kcal·mol −1 ), thus revealing that formation of these two hydrogen bonds is positively cooperative. In contrast, δ AB i is +0.9 ±0.4 kcal·mol −1 for the poorly functional C27A ScYLV RNA, indicative of non-additive hydrogen bond formation. These results reveal that cooperative hydrogen bond formation across the helical stem junction in H-type pseudoknots correlates with enhanced frameshift stimulation by luteoviral mRNA pseudoknots. pseudoknot; frameshifting; protonated cytidine; hydrogen bond coupling Intricately folded motifs in both the noncoding and coding regions of mRNAs are known to regulate all steps of the translation cycle. RNA functions in cap-independent translational initiation by providing a binding site for 40S ribosomal subunits in internal ribosomal entry sites (IRES) (1). Riboswitches are naturally occurring aptamers that bind metabolites including adenine, guanine, S-adenosylmethionine, and thiamine pyrophosphatase that directly regulate the expression of enzymes linked to their production or degradation (2). Folded RNA motifs found in coding regions of mRNAs regulate ribosomal recoding by stimulating stop codon suppression, stop codon redefinition, or change the translational reading frame, an example of which is −1 programmed ribosomal frameshifting (−1 PRF) (3,4). −1 PRF occurs during translational elongation where the mRNA slips back by one nucleotide into the "−1" reading frame relative to the reference "0" frame. In RNA viruses, −1 PRF is used to produce several † 
 Title: Pairwise coupling analysis of helical junction hydrogen bonding interactions in luteoviral RNA pseudoknots † NIH Public Access Author Manuscript
answer:

True