Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: In 1997 the Kymi Province was merged with the Uusimaa Province and the southern parts of the Hame Province into the new Southern Finland Province.

A: What was replaced Kymi Province?
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Q: A significant role for IFN in the pathogenesis of systemic lupus erythematosus is well supported, and clinical trials of anti-IFN monoclonal antibodies are in progress in this disease. In other autoimmune diseases characterized by substantial inflammation and tissue destruction, the role of type I interferons is less clear. Gene expression analysis of peripheral blood cells from patients with rheumatoid arthritis and multiple sclerosis demonstrate an interferon signature similar to but less intense than that seen in patients with lupus. In both of those diseases, presence of the interferon signature has been associated with more significant clinical manifestations. At the same time, evidence supports an anti-inflammatory and beneficial role of IFN locally in the joints of patients with rheumatoid arthritis and in murine arthritis models, and many patients with multiple sclerosis show a clinical response to recombinant IFN. As can also be proposed for type I diabetes mellitus, type I interferon appears to contribute to the development of autoimmunity and disease progression in multiple autoimmune diseases, while maintaining some capacity to control established disease - particularly at local sites of inflammation. Recent studies in both rheumatoid arthritis and multiple sclerosis suggest that quantification of type I interferon activity or target gene expression might be informative in predicting responses to distinct classes of therapeutic agents.

A: Which is the most common gene signature in Rheumatoid Arthritis patients?
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Q: The 2016 World Single Distance Speed Skating Championships will be held between 11 and 14 February 2016 in Kolomna, Russia.

A:
On what date did 2016 World Single Distance Speed Skating Championships end?
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