Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Lack of the yeast Rrm3p DNA helicase causes replication defects at multiple sites within ribosomal DNA (rDNA), including at the replication fork barrier (RFB). These defects were unaltered in rrm3 sir2 cells. When the RFB binding Fob1p was deleted, rrm3-generated defects at the RFB were eliminated, but defects at other rDNA sites were not affected. Thus, specific protein-DNA complexes make replication Rrm3p-dependent. Because rrm3-induced increases in recombination and cell cycle length were only partially suppressed in rrm3 fob1 cells, which still required checkpoint and fork restart activities for viability, non-RFB rrm3-induced defects contribute to rDNA fragility and genome instability.
What is the effect of the absence of Saccharomyces cerevisiae Rrm3p?

The Witte Huis (Dutch pronunciation: (t ys)) or White House is a building and National Heritage Site in Rotterdam, Netherlands, built in 1898 in the Art Nouveau style.
The art style of Witte Huis is what?

Cymbastela is a genus of sponges in the family Axinellidae.

Is the taxon rank of Cymbastela species or genus?