Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

[EX Q]: Context: John Strangways, the British Intelligence (SIS) Station Chief in Jamaica, is ambushed, killed, and his body taken by three assassins known as the "Three Blind Mice". In response, MI6 agent James Bond (007) is summoned to the office of his superior, M. Bond is briefed to investigate Strangways' disappearance and to determine whether it is related to his cooperation with the American Central Intelligence Agency (CIA) on a case involving the disruption of Cape Canaveral rocket launches by radio jamming.Upon his arrival at Kingston Airport, a female photographer tries to take Bond's picture and he is shadowed from the airport. He is picked up by a chauffeur, who Bond determines to be an enemy agent. Bond instructs him to leave the main road and, after a brief fight, Bond starts to interrogate the driver, who then kills himself with a cyanide-embedded cigarette.During his investigation Bond sees a picture of a boatman named Quarrel with Strangways. Bond locates Quarrel but finds him to be un-cooperative when he interviews him. Bond also recognises Quarrel to have been the driver of the car that chased him from the airport. Bond follows Quarrel and is about to be beaten by him and a friend when the fight is interrupted by the man from the airport who has been following Bond: he reveals himself to be CIA agent Felix Leiter and that not only are the two agents on the same mission, but also that Quarrel is helping Leiter. The CIA has traced the mysterious radio jamming of American rockets to the Jamaica vicinity, but aerial photography cannot see the exact location of its origin. Quarrel reveals that he has been guiding Strangways around the nearby islands to collect mineral samples. He also tells about the island of Crab Key, owned by the reclusive Dr. No, who operates a bauxite mine which is rigorously protected against trespassers by an armed security force and low-scan radar.After finding a receipt in Strangways' house about mysterious rocks naming, Professor R.J. Dent, Bond meets with Dent who says he had assayed the samples for Strangways and determined them to be ordinary rocks. This visit makes Dent wary and he takes a boat to Crab Key where Dr. No expresses displeasure at Dent's failure to kill Bond and orders him to try again, this time with a large venomous spider. Bond survives and kills the spider.Bond becomes friendly with Strangways' secretary, Miss Taro and agrees to meet her at her home in the hills above Kingston. While driving there, Bond is attacked by several men driving a large hearse. He is able to outmaneuver them and the hearse is run off the mountain road and explodes. When Bond shows up at Taro's house, she's surprised to see him, a fact that Bond notes easily. She goes into her bedroom and talks on the phone to her boss, who tells her to keep Bond occupied for a few hours. Bond and Taro spend that time in bed.Bond makes a phone call, ostensibly asking for a taxi but actually talking to the local police, who show up soon after and arrest Taro. Bond then sets a trap for Dent and waits for him to show. Dent steals into the bedroom and fires several silenced shots into the bed, which Bond rigged to look like it was occupied. Bond forces Dent to drop his pistol and begins to interrogate him about Strangways and his radioactive rock samples, which Dent tried to cover up. Dent is able to recover his pistol, finding it empty and Bond coldly shoots him dead.Having detected radioactive traces in Quarrel's boat, where Strangways' mineral samples had been, Bond convinces a reluctant Quarrel to take him to Crab Key. On the beach there, Bond meets the beautiful Honey Ryder, dressed only in a white bikini, who is collecting shells. At first she is suspicious of Bond but soon decides to help him, leading them all inland to an open swamp. After nightfall they are attacked by the legendary "dragon" of Crab Key which turns out to be a flame-throwing armoured vehicle. In the resulting gun battle, Quarrel is incinerated by the flame-thrower whilst Bond and Honey are 
 Question: Where did Dent took the boat to?
[EX A]: crab key

[EX Q]: Context: Imatinib mesylate is a new drug that can inhibit the tyrosine kinase activity of Bcr-Abl, the receptors for platelet-derived growth factor receptor(PDGF) and stem cell factor, or c-kit. Chronic myeloid leukemia (CML) is distinguished by the presence of a reciprocal translocation between chromosomes 9 and 22 that results in a shortened chromosome 22, termed the Philadelphia(Ph) chromosome. As a result of the translocation, a fusion gene called the Bcr-Abl gene is created from two normal cellular genes, encoding a chimeric Bcr-Abl protein with a deregulated tyrosine kinase activity. The expression of Bcr-Abl tyrosine kinase has been shown to be necessary and sufficient for the transformed phenotype of CML cells. Imatinib can block the kinase activity of Bcr-Abl, thus inhibiting the proliferation of Ph-positive progenitors, and has shown activity against all phases of CML, though responses are most substantial and durable in patients in the chronic phase. An international phase III study which compared the efficacy of imatinib with that of interferon alpha combined with low-dose cytarabine in newly diagnosed chronic-phase CML showed the rate of major cytogenetic response at 24 months was 90%, including 82% of complete cytogenetic response. These results indicated that imatinib was superior to interferon-containing treatment as a first-line therapy. More than 10,000 patients worldwide, including those in Japan, have been treated with imatinib in clinical trials, and a lot of information has been accumulated on the use of this drug. The aim of this article is to review the use of this drug and the practical management of patients with chronic myeloid leukemia. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
[EX A]: bcr-abl

[EX Q]: Context: Patients with multiple myeloma (MM) experience pathologic fractures, bone pain, hypercalcemia, neurologic symptoms, and renal insufficiency with substantial morbidity and mortality. Bisphosphonates have been used successfully for the management of MM-related bone disease. Increased incidence of osteonecrosis of the jaw has been observed in patients with cancer receiving bisphosphonate therapy. Recent advances in the pathobiology of MM-related bone disease and other cancer-related bone metastases have led to the identification of novel therapeutic targets, such as receptor activator of nuclear factor-kappaB (RANK); its ligand (RANKL); and a decoy receptor, osteoprotegerin, for the development of potential targeted agents. Initials studies have demonstrated that targeting RANK/ RANKL signaling with the fully human monoclonal antibody denosumab prevented skeletal complications in patients with MM and other cancers with bone metastases. Ongoing studies evaluating the clinical utility of denosumab in cancer- related bone destruction have been discussed. In addition, several potential targets, such as macrophage inflammatory protein-1alpha, chemokine receptors 1 and 5, interleukin-3, and Wnt signaling, are b riefly described. 
 Question: To the ligand of which receptors does Denosumab (Prolia) bind?
[EX A]:
rankl