Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: Mercury is the smallest planet. It has no moon. The planet is also closest to the Sun and appears in Figure 25.7. As Figure 25.8 shows, the surface of Mercury is covered with craters, like Earths Moon. The presence of impact craters that are so old means that Mercury hasnt changed much geologically for billions of years. With only a trace of an atmosphere, it has no weather to wear down the ancient craters. Because Mercury is so close to the Sun, it is difficult to observe from Earth, even with a telescope. The Mariner 10 spacecraft did a flyby of Mercury in 19741975, which was the best data from the planet for decades. In 2004, the MESSENGER mission left Earth. On its way to Mercury it did one flyby of Earth, two of Venus and three of Mercury. In March 2011, MESSENGER became the first spacecraft to enter an orbit around Mercury. During its year-long mission, the craft will map the planets surface and conduct other studies. One of these images can be seen in Figure 25.9. Mercury is named for the Roman messenger god. Mercury was a messenger because he could run extremely fast. The Greeks gave the planet this name because Mercury moves very quickly in its orbit around the Sun. Mercury orbits the Sun in just 88 Earth days. Mercury has a very short year, but it also has very long days. Mercury rotates slowly on its axis, turning exactly three times for every two times it orbits the Sun. Therefore, each day on Mercury is 58 Earth days long. Mercury is very close to the Sun, so it can get very hot. Mercury also has virtually no atmosphere. As the planet rotates very slowly, the temperature varies tremendously. In direct sunlight, the surface can be as hot as 427C (801F). On the dark side, the surface can be as cold as 183C (297F)! The coldest temperatures may be on the insides of craters. Most of Mercury is extremely dry. Scientists think that there may be a small amount of water, in the form of ice, at the planets poles. The poles never receive direct sunlight. Figure 25.10 shows a diagram of Mercurys interior. Mercury is one of the densest planets. Scientists think that the interior contains a large core made mostly of melted iron. Mercurys core takes up about 42% of the planets volume. Mercurys highly cratered surface is evidence that Mercury is not geologically active. Named after the Roman goddess of love, Venus is the only planet named after a female. Venus is sometimes called Earths sister planet. But just how similar is Venus to Earth? Venus is our nearest neighbor. Venus is most like Earth in size. Viewed through a telescope, Venus looks smooth and featureless. The planet is covered by a thick layer of clouds. You can see the clouds in pictures of Venus, such as Figure 25.11. We make maps of the surface using radar, because the thick clouds wont allow us to take photographs of the surface of Venus. Figure 25.12 shows the topographical features of Venus. The image was produced by the Magellan probe on a flyby. Radar waves sent by the spacecraft reveal mountains, valleys, vast lava plains, and canyons. Like Mercury, Venus does not have a moon. Clouds on Earth are made of water vapor. Venuss clouds are a lot less pleasant. They are made of carbon dioxide, sulfur dioxide and large amounts of corrosive sulfuric acid! The atmosphere of Venus is so thick that the pressure on the surface of Venus is very high. In fact, it is 90 times greater than the pressure at Earths surface! The thick atmosphere causes a strong greenhouse effect. As a result, Venus is the hottest planet. Even though it is farther from the Sun, Venus is much hotter even than Mercury. Temperatures at the surface reach 465C (860F). Thats hot enough to melt lead! Venus has more volcanoes than any other planet. There are between 100,000 and one million volcanoes on Venus! Most of the volcanoes are now inactive. There are also a large number of craters. This means 
 Question: The inner planet with an average surface temperature of 14 C is
earth.

Context: The aim of this study was to elucidate the role of lysyl oxidase (LOX) and lysyl oxidase like (LOXL) 2 in pathologic wound healing after glaucoma surgery. We therefore investigated the expression of LOX and LOXL2 and evaluated the therapeutic potential of anti-LOX (GS-639556, formerly M64) and anti-LOXL2 (GS-607601, formerly AB0023) antibodies in a rabbit model of glaucoma trabeculectomy. Ocular expression of LOX and LOXL2 was investigated by immunohistologic staining at different time points after trabeculectomy. Treatment with GS-639556 or GS-607601 was initiated in rabbits immediately after trabeculectomy by giving both intracameral and subconjunctival injections. Thereafter, the antibodies were given twice a week subconjunctivally until day 30 after surgery (day of euthanization). Treatment outcome was studied by clinical investigation of the bleb and by immunohistochemical analysis of angiogenesis, inflammation, and collagen deposition. LOX and LOXL2 were both upregulated in Tenon's capsule and the conjunctiva after glaucoma surgery. Repeated administration of LOX- or LOXL2-targeting monoclonal antibodies increased bleb area and bleb survival. Analyses of immunohistologic stainings showed that both antibodies significantly decreased fibrosis, whereas the anti-LOXL2 antibody also significantly reduced blood vessel density and inflammation. Targeting LOXL2 with an inhibitory monoclonal antibody (GS-607601) reduced pathologic angiogenesis, inflammation, and fibrosis. These results suggest that LOXL2 could be an appealing target for treatment of scar formation after glaucoma surgery, and point to the potential therapeutic benefits of simtuzumab, a humanized monoclonal antibody derived from GS-607601. 
 Question: What is the drug target for Simtuzumab?
loxl2

Context: When two or more waves meet, they interact with each other. The interaction of waves with other waves is called wave interference. Wave interference may occur when two waves that are traveling in opposite directions meet. The two waves pass through each other, and this affects their amplitude. Amplitude is the maximum distance the particles of the medium move from their resting positions when a wave passes through. How amplitude is affected by wave interference depends on the type of interference. Interference can be constructive or destructive. Constructive interference occurs when the crests, or highest points, of one wave overlap the crests of the other wave. You can see this in the Figure 1.1. As the waves pass through each other, the crests combine to produce a wave with greater amplitude. Destructive interference occurs when the crests of one wave overlap the troughs, or lowest points, of another wave. The Figure 1.2 shows what happens. As the waves pass through each other, the crests and troughs cancel each other out to produce a wave with zero amplitude. Waves may reflect off an obstacle that they are unable to pass through. When waves are reflected straight back from an obstacle, the reflected waves interfere with the original waves and create standing waves. These are waves that appear to be standing still. Standing waves occur because of a combination of constructive and destructive interference. Q: How could you use a rope to produce standing waves? A: You could tie one end of the rope to a fixed object, such as doorknob, and move the other end up and down to generate waves in the rope. When the waves reach the fixed object, they are reflected back. The original waves and the reflected waves interfere to produce a standing wave. Try it yourself and see if the waves appear to stand still. 
 Question: when two waves pass through each other in opposite directions, the interference affects their

amplitude.