TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Siltuximab, a chimeric monoclonal antibody with high affinity and specificity for interleukin-6, has been shown to enhance anti-multiple myeloma activity of bortezomib and corticosteroid in vitro. We evaluated the safety, pharmacokinetics, immunogenicity, and antitumor effect of siltuximab in combination with bortezomib and dexamethasone in Japanese patients with relapsed or refractory multiple myeloma. This open-label, phase 1, dose-escalating study used two doses of siltuximab: 5.5 and 11.0 mg/kg (administered on day 1 of each 21-day cycle). In total, nine patients were treated. The most common grade 3/4 adverse events, lymphopenia (89 %) and thrombocytopenia (44 %), occurred in patients receiving both doses of siltuximab; however, no dose-limiting toxicities (DLTs) were observed. Following intravenous administration of siltuximab at 5.5 and 11.0 mg/kg, the maximum serum concentration and the area under the curve from 0 to 21 days and from 0 to infinity increased in an approximately dose-proportional manner. Mean half-life, total systemic clearance, and volume of distribution were similar at doses of 5.5 and 11.0 mg/kg. Across both doses, six of the nine patients had complete or partial response (22 and 44 %, respectively). In conclusion, as no DLT was observed, the recommended dose for this combination is 11.0 mg/kg once every 3 weeks. The study is registered at [Link] as NCT01309412.

SOLUTION: Which interleukin is blocked by Siltuximab?

PROBLEM: Grant Heslov (born May 15, 1963) is an American actor, film producer, screenwriter and director, known for producing Argo (2012) for which he received an Academy Award for Best Picture as co-producer in 2013.

SOLUTION: What was Grant Heslov nominated for?

PROBLEM: You may know your mother, but how well do you really know Mothers' Day? Cards, flowers, sales, TV specials, and a day off for someone who really deserves it -- those are what probably come to mind for many people when they think of Mothers' Day. But there's more to the story. The earliest Mothers' Day celebrations were held during spring in ancient Greece. The celebrations honored Rhea, the mother of the gods. During the 1600's, England celebrated a day called Mothering Sunday. On this day even servants were given the day off to spend with their families. A mothering cake was even served with the family meal. In the US, Mothers' Day began in 1872 when Julia Ward Howe, who wrote the words to the famous song The Battle Hymn of the Republic, suggested it as a day devoted to peace. But it didn't really become popular until 1907 when Anna Jarvis started a campaign to honor mothers. She believed that mothers could help people get over the pain they experienced during the Civil War. The US isn't alone in devoting a day to mothers. Many other countries including Denmark, Finland, Italy, Turkey, Australia, Japan, and Belgium also honor their mothers in May. Other countries honor their mothers at different times of the year. Learning more about Mothers' Day and celebrating Mothers' Day are important, but probably not as important as understanding what your own mother, or grandmother, or aunt has really done for you. And that will certainly be appreciated more than one day in year.

SOLUTION:
Where was the earliest Mothers' Day celebrated?