Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

[Q]: Paragraph: People who became ill attended the private function Nov. 24 at the Puritan Backroom conference center in Manchester, the state Department of Health and Human Services said Friday. One person later died, but it was unclear if the death was related to the norovirus outbreak, the department said. The restaurant is co-owned by U.S. Rep. Chris Pappas and is famous for its chicken tenders. It has been in his family for more than a century and is a frequent stop for presidential candidates of both parties. The nature of the event was not released, but it didn’t appear that any current presidential candidates attended. The manager of the Puritan Backroom, Erik Zink, said in a written statement that the restaurant’s top priorities are promoting health and excellent food safety and that he was confident it was doing everything possible to maintain those practices. Zink also said the restaurant had reached out to the family of the person who died to express “our condolences” for the death, which he blamed on unidentified causes. After the outbreak, the Manchester Health Department conducted an inspection of the restaurant. Officials determined there was no ongoing norovirus risk to the public. The symptoms of norovirus include diarrhea, vomiting, nausea and stomach pain, health officials said. The state sees 50 to 75 norovirus outbreaks every year. Claim: 18 sickened at popular New Hampshire primary campaign stop.
[A]: A norovirus sickened 18 people after a private function last month at a restaurant co-owned by a Democratic congressman that is popular with presidential candidates campaigning in the New Hampshire primary, state health officials said.


[Q]: Paragraph: Cancer patients increasingly are having their care guided by gene tumor boards, a new version of the hospital panels that traditionally decided whether surgery, radiation or chemotherapy would be best. These experts study the patient’s cancer genes and match treatments to mutations that seem to drive the disease. “We dissect the patient’s tumor with what I call the molecular microscope,” said Dr. Razelle Kurzrock, who started a board at the University of California, San Diego, where Cairnes is treated. It’s the kind of care many experts say we should aim for — precision medicine, the right drug for the right person at the right time, guided by genes. There are success stories, but also some failures and many questions: Will gene-guided care improve survival? Does it save money or cost more? What kind of gene testing is best, and who should get it? “I think every patient needs it,” especially if cancer is advanced, said Kurzrock, who consults for some gene-medicine companies. “Most people don’t agree with me — yet. In five years, it may be malpractice not to do genomics.” Few people get precision medicine today, said Dr. Eric Topol, head of the Scripps Translational Science Institute. “The only thing that’s gone mainstream are the words.” HOW IT WORKS NOW If you have a cancer that might be susceptible to a gene-targeting drug, you may be tested for mutations in that gene, such as HER2 for breast cancer. Some breast or prostate cancer patients also might get a multi-gene test to gauge how aggressive treatment should be. Then most patients get usual guideline-based treatments. If there’s no clear choice, or if the disease has spread or comes back, doctors may suggest tumor profiling — comprehensive tests to see what mutations dominate. That’s traditionally been done from a tissue sample, but newer tests that detect tumor DNA in blood — liquid biopsies — are making profiling more common. The tests cost about $6,000 and many insurers consider them experimental and won’t pay. Gene tumor boards analyze what the results suggest about treatment. They focus on oddball cases like a breast cancer mutation in a colon cancer patient, or cancers that have widely spread and are genetically complex. The only options may be experimental drugs or “off-label” treatments — medicines approved for different situations. But as tumor profiling grows, it’s revealing how genetically diverse many tumors are, and that oddball cases are not so rare, said Dr. John Marshall. He heads the virtual tumor board at Georgetown Lombardi Comprehensive Cancer Center that also serves cancer centers in Pennsylvania, North Carolina, Michigan and Tennessee. “There is a little bit of faith” that testing will show the right treatment, but it’s not a sure thing, said Dr. Lee Schwartzberg, who heads one participating center, the West Cancer Center in Memphis. Dr. Len Lichtenfeld, the American Cancer Society’s deputy chief medical officer, is optimistic yet wary. Drugs that target BRAF mutations work well for skin cancers called melanomas, but less well for lung or colon cancers. “Just because a mutation occurs it doesn’t mean that drug is going to work in that cancer,” he said. LUCKY CASES When it does, results can be dramatic. Cairnes’ cancer was between her stomach and esophagus, and had spread to her liver, lungs and lymph nodes. Tissue testing found 10 abnormal genes, but on the liquid biopsy only EGFR popped out as a good target. Two drugs aim at that gene but aren’t approved for her type of cancer. A tumor board advised trying both — Erbitux and Tarceva, the drug her husband also had taken. Within two weeks, she quit using pain medicines. After two months, her liver tumor had shrunk roughly by half. There are signs that cancer may remain, but it is under control. She feels well enough to travel and to take care of her granddaughter. “I’m very, very grateful to have a targeted therapy,” Cairnes said. “I cannot expect a better outcome than what we’re seeing right now,” said her doctor, Shumei Kato. WHAT STUDIES SHOW But is gene-guided treatment better than usual care? French doctors did the first big test, with disappointing results. About 200 patients with advanced cancer were given whatever their doctors thought best or off-label drugs based on tumor profiling. Survival was similar — about two months. Another French study, reported in June, was slightly more encouraging on survival but exposed another problem: No drugs exist for many gene flaws. Tests found treatable mutations in half of the 2,000 participants and only 143 got what a tumor board suggested. Some doctors worry that tumor boards’ recommending off-label treatments diverts patients from research that would benefit all cancer patients. For example, the American Society of Clinical Oncology’s TAPUR study tests off-label drugs and shares results with their makers and federal regulators. LETTING PATIENTS CHOOSE Ann Meffert, who lives on a dairy farm in Waunakee, Wisconsin, endured multiple standard treatments that didn’t defeat her bile duct cancer. “She was going to be referred to hospice; there was not much we could do,” said Dr. Nataliya Uboha, who took the case to a tumor board at the University of Wisconsin-Madison. The panel gave several options, including off-label treatment, and Meffert chose a study that matches patients to gene-targeting therapies and started on an experimental one last October. “Two weeks in, I started feeling better,” she said, and when she saw test results, “I couldn’t believe the difference.” Many lung spots disappeared and the liver tumor shrank 75 percent. She is not cured, though, and doctors are thinking about next steps. And that could involve a fresh look at her tumor genes. ___ Marilynn Marchione can be followed at @MMarchioneAP __ This Associated Press series was produced in partnership with the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. Claim: Ultra-personal therapy: Gene tumor boards guide cancer care.
[A]: Doctors were just guessing a decade ago when they gave Alison Cairnes’ husband a new drug they hoped would shrink his lung tumors. Now she takes it, but the choice was no guesswork. Sophisticated gene tests suggested it would fight her gastric cancer, and they were right.


[Q]: Paragraph: U.S. first lady Michelle Obama participates during breakout sessions at the Young African Youth Leaders Forum in Johannesburg, June 22, 2011. REUTERS/Charles Dharapak/Pool Obama is on her second solo trip abroad as first lady to promote issues such as education, health and wellness. But her speech to a group of young women and men at Regina Mundi Church, which played a role in South Africa’s anti-apartheid movement, touched on much harder topics: race, discrimination, democracy and development. Obama, who is traveling with her mother and two daughters, cited the leaders of the anti-apartheid movement in South Africa and the civil rights movement in the United States as examples for the younger generation to follow. “It is because of them that we are able to gather here today...It is because of them that I stand before you as First Lady of the United States of America,” she said to applause. “That is the legacy of the independence generation, the freedom generation. And all of you — the young people of this continent — you are the heirs of that blood, sweat, sacrifice and love.”   Obama appeared visibly moved when the audience stood and sang an impromptu serenade as she approached the podium. Placing her hands over her heart, she thanked the crowd and seemed to choke back tears. She spoke passionately about women’s rights, saying the young leaders should ensure that women were no longer “second class citizens” and that girls were educated in schools. “You can be the generation that stands up and says that violence against women in any form, in any place, including the home — especially the home — that isn’t just a women’s rights violation. It’s a human rights violation,” she said. “You can be the generation that ends HIV/AIDS in our time, the generation that fights not just the disease, but the stigma of the disease, the generation that teaches the world that HIV is fully preventable and treatable, and should never be a source of shame,” she said to applause. Obama was introduced by Graca Machel, Nelson Mandela’s wife. She and her family met Mandela at his home Tuesday. Mrs. Obama said she told Mandela that he had been an inspiration to her and her husband, the first black president of the United States. “I told him that words can’t express how much your life has meant to who my husband is and who I am,” she said. “You know what he said? ‘OK, thanks,’” she continued, laughing. “There’s nothing new I can say to Nelson Mandela. But I felt good about being able to just say: ‘This is your legacy’.”   The first lady said President Obama had not known whether she would meet with Mandela. “I still haven’t talked to the president,” Mrs. Obama said Wednesday afternoon. “He talked to the kids last night. I was tired.”   She used her husband’s famous campaign slogan, which helped him win the 2008 presidential election, to urge the church audience to follow through on the issues she addressed. “If anyone ever tells you that you shouldn’t or you can’t, then I want you to say with one voice — the voice of a generation — you tell them: “Yes, we can.” Claim: Michelle Obama urges Africa to advance women's rights.
[A]:
First Lady Michelle Obama urged young Africans Wednesday to fight for women’s rights and battle the stigma of AIDS, using her husband’s “yes, we can” campaign slogan to motivate youth across the continent.