Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: Diabetic nephropathy is the leading cause of end-stage renal disease in humans in the Western world. The recent development of Na+-glucose cotransporter 2 (SGLT2) inhibitors offers a new antidiabetic therapy via enhanced glucose excretion. Whether this strategy exerts beneficial effects on the development of type 2 diabetic nephropathy is still largely unclear. We investigated the effects of the specific SGLT2 inhibitor empagliflozin in BTBR.Cg-Lep<ob>/WiscJ (BTBR ob/ob) mice, which spontaneously develop type 2 diabetic nephropathy. In the first experiment, BTBR ob/ob mice received either a diet containing 300 ppm empagliflozin or equicaloric placebo chow for 12 wk. In the second experiment, BTBR ob/ob mice received 1 gkg body wt(-1)day(-1) ANG II to induce arterial hypertension and were separated into the same two diet groups for 6 wk. In both experiments, empagliflozin treatment enhanced glucosuria, thereby lowering blood glucose. Independently of hypertension, empagliflozin reduced albuminuria in diabetic mice. However, empagliflozin treatment affected diabetes-related glomerular hypertrophy, markers of renal inflammation, and mesangial matrix expansion only in BTBR ob/ob mice without hypertension. In summary, empagliflozin demonstrated significant antihyperglycemic effects, differentially ameliorating early features of diabetic nephropathy in BTBR ob/ob mice with and without hypertension.
[EX A]: Which protein does empagliflozin inhibit?

[EX Q]: In the Atlantic, the West India Company concentrated on wresting from Portugal its grip on the sugar and slave trade, and on opportunistic attacks on the Spanish treasure fleets on their homeward bound voyage. Bahia on the north east coast of Brazil was captured in 1624 but only held for a year before it was recaptured by a joint Spanish-Portuguese expedition. In 1628, Piet Heyn captured the entire Spanish treasure fleet, and made off with a vast fortune in precious metals and goods that enabled the Company two years later to pay its shareholders a cash dividend of 70%, though the Company was to have relatively few other successes against the Spanish. In 1630, the Dutch occupied the Portuguese sugar-settlement of Pernambuco and over the next few years pushed inland, annexing the sugar plantations that surrounded it. In order to supply the plantations with the manpower they required, a successful expedition was launched in 1637 from Brazil to capture the Portuguese slaving post of Elmina, and in 1641 successfully captured the Portuguese settlements in Angola. In 1642, the Dutch captured the Portuguese possession of Axim in Africa. By 1650, the West India Company was firmly in control of both the sugar and slave trades, and had occupied the Caribbean islands of Sint Maarten, Curacao, Aruba and Bonaire in order to guarantee access to the islands' salt-pans.
[EX A]: What were two things the West India Company desired?

[EX Q]: Menpehtyre Ramesses I (traditional English: Ramesses or Ramses) was the founding pharaoh of ancient Egypt's 19th dynasty.
[EX A]:
What is the position of Ramesses I?