Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

Paragraph: Cancer patients increasingly are having their care guided by gene tumor boards, a new version of the hospital panels that traditionally decided whether surgery, radiation or chemotherapy would be best. These experts study the patient’s cancer genes and match treatments to mutations that seem to drive the disease. “We dissect the patient’s tumor with what I call the molecular microscope,” said Dr. Razelle Kurzrock, who started a board at the University of California, San Diego, where Cairnes is treated. It’s the kind of care many experts say we should aim for — precision medicine, the right drug for the right person at the right time, guided by genes. There are success stories, but also some failures and many questions: Will gene-guided care improve survival? Does it save money or cost more? What kind of gene testing is best, and who should get it? “I think every patient needs it,” especially if cancer is advanced, said Kurzrock, who consults for some gene-medicine companies. “Most people don’t agree with me — yet. In five years, it may be malpractice not to do genomics.” Few people get precision medicine today, said Dr. Eric Topol, head of the Scripps Translational Science Institute. “The only thing that’s gone mainstream are the words.” HOW IT WORKS NOW If you have a cancer that might be susceptible to a gene-targeting drug, you may be tested for mutations in that gene, such as HER2 for breast cancer. Some breast or prostate cancer patients also might get a multi-gene test to gauge how aggressive treatment should be. Then most patients get usual guideline-based treatments. If there’s no clear choice, or if the disease has spread or comes back, doctors may suggest tumor profiling — comprehensive tests to see what mutations dominate. That’s traditionally been done from a tissue sample, but newer tests that detect tumor DNA in blood — liquid biopsies — are making profiling more common. The tests cost about $6,000 and many insurers consider them experimental and won’t pay. Gene tumor boards analyze what the results suggest about treatment. They focus on oddball cases like a breast cancer mutation in a colon cancer patient, or cancers that have widely spread and are genetically complex. The only options may be experimental drugs or “off-label” treatments — medicines approved for different situations. But as tumor profiling grows, it’s revealing how genetically diverse many tumors are, and that oddball cases are not so rare, said Dr. John Marshall. He heads the virtual tumor board at Georgetown Lombardi Comprehensive Cancer Center that also serves cancer centers in Pennsylvania, North Carolina, Michigan and Tennessee. “There is a little bit of faith” that testing will show the right treatment, but it’s not a sure thing, said Dr. Lee Schwartzberg, who heads one participating center, the West Cancer Center in Memphis. Dr. Len Lichtenfeld, the American Cancer Society’s deputy chief medical officer, is optimistic yet wary. Drugs that target BRAF mutations work well for skin cancers called melanomas, but less well for lung or colon cancers. “Just because a mutation occurs it doesn’t mean that drug is going to work in that cancer,” he said. LUCKY CASES When it does, results can be dramatic. Cairnes’ cancer was between her stomach and esophagus, and had spread to her liver, lungs and lymph nodes. Tissue testing found 10 abnormal genes, but on the liquid biopsy only EGFR popped out as a good target. Two drugs aim at that gene but aren’t approved for her type of cancer. A tumor board advised trying both — Erbitux and Tarceva, the drug her husband also had taken. Within two weeks, she quit using pain medicines. After two months, her liver tumor had shrunk roughly by half. There are signs that cancer may remain, but it is under control. She feels well enough to travel and to take care of her granddaughter. “I’m very, very grateful to have a targeted therapy,” Cairnes said. “I cannot expect a better outcome than what we’re seeing right now,” said her doctor, Shumei Kato. WHAT STUDIES SHOW But is gene-guided treatment better than usual care? French doctors did the first big test, with disappointing results. About 200 patients with advanced cancer were given whatever their doctors thought best or off-label drugs based on tumor profiling. Survival was similar — about two months. Another French study, reported in June, was slightly more encouraging on survival but exposed another problem: No drugs exist for many gene flaws. Tests found treatable mutations in half of the 2,000 participants and only 143 got what a tumor board suggested. Some doctors worry that tumor boards’ recommending off-label treatments diverts patients from research that would benefit all cancer patients. For example, the American Society of Clinical Oncology’s TAPUR study tests off-label drugs and shares results with their makers and federal regulators. LETTING PATIENTS CHOOSE Ann Meffert, who lives on a dairy farm in Waunakee, Wisconsin, endured multiple standard treatments that didn’t defeat her bile duct cancer. “She was going to be referred to hospice; there was not much we could do,” said Dr. Nataliya Uboha, who took the case to a tumor board at the University of Wisconsin-Madison. The panel gave several options, including off-label treatment, and Meffert chose a study that matches patients to gene-targeting therapies and started on an experimental one last October. “Two weeks in, I started feeling better,” she said, and when she saw test results, “I couldn’t believe the difference.” Many lung spots disappeared and the liver tumor shrank 75 percent. She is not cured, though, and doctors are thinking about next steps. And that could involve a fresh look at her tumor genes. ___ Marilynn Marchione can be followed at @MMarchioneAP __ This Associated Press series was produced in partnership with the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. Claim: Ultra-personal therapy: Gene tumor boards guide cancer care.
Doctors were just guessing a decade ago when they gave Alison Cairnes’ husband a new drug they hoped would shrink his lung tumors. Now she takes it, but the choice was no guesswork. Sophisticated gene tests suggested it would fight her gastric cancer, and they were right.

Paragraph: The Rhode Island Department of Health and the state Department of Environmental Management earlier this week announced that seasonal cooling and declining daylight have signaled a great reduction in risk. However, officials said there's no guarantee the toxins are absent, warning that a warm spell could trigger an algae bloom during the winter or spring. While the seasonal monitoring of cyanobacteria in 2019 is complete, the public is reminded to avoid contact with any body of water that appears to be bright green or has a dense, floating mass on the surface. Blue-green algae blooms may also look like green paint or thick pea soup and the toxins may still persist in the water even if the bloom is no longer visible. Advisories have been lifted for Paradise Pond in Middletown, Sisson Pond in Portsmouth, Slack Reservoir in Smithfield-Johnston, Carbuncle Pond in Coventry, Almy Pond in Newport, Elm Lake in Providence, JL Curran Resevoir in Cranston, Mashapaug, Pleasure and Roosevelt ponds in Providence, and Melville Pond in Portsmouth. As of earlier this week, an advisory was still in place for Watson Reservoir in Little Compton, where there were still visual signs of a cyanobacteria bloom. People who come into contact with potentially affected waters should rinse their skin and wash their clothes with clean water as soon as possible. Meanwhile, people with pets that exhibit adverse health symptoms after coming in contact with potentially affected waters should contact their veterinarians. Claim: Rhode Island officials lift advisories for blue-green algae.
Rhode Island health and environmental officials have lifted recreational advisories that have been in place for a number of bodies of water because of a blue-green algae known as cyanobacteria.

Paragraph: Gov. John Bel Edwards, a Democrat, said the decision could eliminate insurance coverage for 480,000 people enrolled in Louisiana’s Medicaid expansion program and 850,000 residents who are estimated to have pre-existing conditions. He criticized Attorney General Jeff Landry for joining other Republican attorneys general in support of the Texas lawsuit challenging the Affordable Care Act. Edwards said the lawsuit creates uncertainty for hundreds of thousands of people in Louisiana. “Being diagnosed with breast cancer or diabetes should not automatically mean that you are denied coverage to protect an insurance company’s profits, and if you put in a full day’s work, you should not be priced out of coverage,” Edwards said in a statement. “This was a short-sighted lawsuit, to say the least.” Landry defended his decision to join the lawsuit, calling the health law an “unconstitutional federal overreach.” “For John Bel Edwards to say the only solution for health care is Obamacare shows he is more interested in playing politics than solving problems,” Landry said in a statement Monday. “We can truly lower costs, improve health care access and cover pre-existing conditions if people set aside politics and work together.” Edwards said he intends to seek state law changes to require coverage of people with pre-existing conditions, and Landry said he was talking with state lawmakers about the same idea. The governor sent a letter Monday to Republican House Speaker Taylor Barras describing the legislation he’ll support, which also would allow children to stay on their parents’ health insurance until the age of 26 and restrict benefit limits for health coverage. Edwards said Rep. Chad Brown, a Democrat from Plaquemine, will sponsor the measure for consideration in the legislative session that starts in April. Friday’s ruling in the federal court in Texas isn’t expected to take effect during the appeals process, with the federal health department saying it will continue administering and enforcing the law. Claim: Louisiana leaders exchange barbs over health care ruling.

Louisiana’s governor and attorney general are trading criticism and suggesting state legislation in the wake of a Texas federal judge’s ruling that, if upheld, will jettison the entire federal health care overhaul.