Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: The film opens with Soichi Negishi (Kenichi Matsuama) walking along side his mother to a small country train station. Negishi hopes to move to Japan, and realize his musical dreams, as a pop singer. As he rides away in the train, he sees his younger brother wave to him from a field.Now we are taken to a dark alleyway, where many alternative Japanese youths are entering a club called "Hell's Gate." Inside we see a death metal band(in rather flamboyant attire, and black and white make-up) preforming for a large crowd. This band, is Detroit Metal City. The singer, is then revealed to be Negashi, and why crowd surfing he narrates of his dislike of what he has become.The opening credits roll.We now see Negashi removing his makeup with a rag, and talking a fellow band mate, which is his lazy, bloomer obsessed drummer Terumichi Nishida . He begs Nishida to return a video-game he had let him borrow, out of fear of him losing it. Now the band's bassist Masayuki Wada speaks to Negashi about how well he believed the show had done.The dressing room door bursts open, and with a wild laugh the President Of Death Records(who also seems to be the band's manager) enters, and tosses a cigarette into a ash tray that Wada held, but it simply bounced out and went out of frame. She told them of how well they did, but in remorse Negashi played for her a tape of the pop music he wishes to make. Displeased, she kicked him.Now with a swollen mouth, Negashi leaves the dressing room in his normal attire, and pushes his way through the crowd of oblivious screaming fans, hoping to get a look at the band. He is hit, and begins to bleed from the nose. As he made his way up the stairs, he heard the fans talk of rumors they had heard about the lead singer Krauser, such as his ability to rape many women.Negashi is now on the street, and he is playing his pop music on an acoustic guitar, with people only stoping to glance at him, and then walk away. He stops playing and hears some pop music being played around the corner. As he goes to investigate he sees that the lead singer of the band was an old college friend, and then that a woman standing near him was his college crush Yuri Aikawa.He reflects on the old days, of them all sitting around playing music together, and of his quote "No music, No dream."He is soon at a record store, looking at the latest fashionable cd covers, when he sees Aikawa, and they began to chat, and make plans to meet later at a cafe. Then a blast of near-by music startles him, and he walks to the next isle to investigate. Several DMC fans had gathered to celebrate the release of a new single with head-banging, and loud music. Negashi dislikes the album cover, and complains about a quote that was in his name, that he never said. Aikawa then tells him of her distaste for metal, and how unfashionable she finds Detroit Metal City.Negashi is now in full attire with his band, doing an interview about the new single. His mind is off daydreaming about Aikawa when he realizes it is time for their date and he runs out of the interview to meet her. Negashi is now constantly going back and forth between the date, and the interview, each time forgetting to remove more and more of his DMC attire. With a feeling that negashi was going into the near-by club, she enters in hopes of finding him, but meets Krauser crowd surfing. Negashi in fear, tries to get the crowd to move him away from her, but the get him closer and closer, until he felt his wig began to slip off. The only thing he could do to cover himself, was to lift up her dress, showing her underwear. She calls him a pig, and walks out.Now Negashi is outside of a cafe, and is banging on the wall in 
 Question: Who disapproves of Negishi's cheesy pop songs?
the band's manager and president of death  records.

Context: A malaria vaccine could be an important addition to current control strategies. We report the safety and vaccine efficacy (VE) of the RTS,S/AS01 vaccine during 18 mo following vaccination at 11 African sites with varying malaria transmission. 6,537 infants aged 6-12 wk and 8,923 children aged 5-17 mo were randomized to receive three doses of RTS,S/AS01 or comparator vaccine. VE against clinical malaria in children during the 18 mo after vaccine dose 3 (per protocol) was 46% (95% CI 42% to 50%) (range 40% to 77%; VE, p<0.01 across all sites). VE during the 20 mo after vaccine dose 1 (intention to treat [ITT]) was 45% (95% CI 41% to 49%). VE against severe malaria, malaria hospitalization, and all-cause hospitalization was 34% (95% CI 15% to 48%), 41% (95% CI 30% to 50%), and 19% (95% CI 11% to 27%), respectively (ITT). VE against clinical malaria in infants was 27% (95% CI 20% to 32%, per protocol; 27% [95% CI 21% to 33%], ITT), with no significant protection against severe malaria, malaria hospitalization, or all-cause hospitalization. Post-vaccination anti-circumsporozoite antibody geometric mean titer varied from 348 to 787 EU/ml across sites in children and from 117 to 335 EU/ml in infants (per protocol). VE waned over time in both age categories (Schoenfeld residuals p<0.001). The number of clinical and severe malaria cases averted per 1,000 children vaccinated ranged across sites from 37 to 2,365 and from -1 to 49, respectively; corresponding ranges among infants were -10 to 1,402 and -13 to 37, respectively (ITT). Meningitis was reported as a serious adverse event in 16/5,949 and 1/2,974 children and in 9/4,358 and 3/2,179 infants in the RTS,S/AS01 and control groups, respectively. RTS,S/AS01 prevented many cases of clinical and severe malaria over the 18 mo after vaccine dose 3, with the highest impact in areas with the greatest malaria incidence. VE was higher in children than in infants, but even at modest levels of VE, the number of malaria cases averted was substantial. RTS,S/AS01 could be an important addition to current malaria control in Africa. www.ClinicalTrials.gov NCT00866619 Please see later in the article for the Editors' Summary. 
 Question: RTS S AS01 vaccine was developed to prevent which disease?
malaria

Context: Progressive supranuclear palsy (PSP) is a neurodegenerative tauopathy characterized by Parkinsonism, vertical gaze palsy, and early falls. Lewy bodies (LBs) are detected in approximately 10% of PSP cases, but there is little information on the relationship of LBs to tau pathology. We determined the frequency of LBs in a large series of autopsy-confirmed cases of PSP and studied the density and distribution of LBs, including Parkinson disease stage, in cases with LBs (PSP/LBD). PSP/LBD was compared with pure LB disease (LBD), including assessment of neuronal loss in key brainstem nuclei. Immunohistochemistry for alpha-synuclein revealed LBs in 31 of 290 PSP cases (11%). One case had multiple system atrophy in addition to PSP and was excluded from further study along with 2 PSP/LBD cases with concurrent Alzheimer disease. The 29 cases of PSP/LBD were compared with 30 cases of PSP and 24 cases of LBD. The age, sex, brain weight, Braak neurofibrillary tangle (NFT) stage, as well as counts of NFTs and senile plaques were not different among PSP, LBD, and PSP/LBD, but disease duration was longer in LBD. The Parkinson disease stage was similar, but the density of LBs in most subcortical nuclei tended to be greater in LBD than in PSP/LBD. In contrast, substantia nigra neuronal loss was greater in PSP/LBD than both PSP and LBD. Double immunostaining demonstrated alpha-synuclein and tau in different neurons with few exceptions. The findings suggest that LBs in PSP are similar in distribution to those in LBD and independent of tau pathology. The greater density of LBs in LBD compared with PSP/LBD may be the result of longer disease duration in LBD, whereas greater neuronal loss in the substantia nigra in PSP/LBD may be the result of vulnerability of this brain region to both disease processes. 
 Question: Against which protein is the antibody used for immonostaining of Lewy bodies raised?

alpha-synuclein