instruction:
In this task, you are given a context, a subject, a relation, and many options. Based on the context, from the options select the object entity that has the given relation with the subject. Answer with text (not indexes).
question:
Context: The Toronto Maple Leafs (officially the Toronto Maple Leaf Hockey Club) are a professional ice hockey team based in Toronto, Ontario. They are members of the Atlantic Division of the Eastern Conference of the National Hockey League (NHL). The team is one of the "Original Six" league members. They are owned by Maple Leaf Sports & Entertainment, Ltd. and are represented by Chairman Larry Tanenbaum. In February 1999, they moved to the Air Canada Centre, which replaced Maple Leaf Gardens, the team's home since 1931., The New Jersey Devils are a professional ice hockey team based in Newark, New Jersey. They are members of the Metropolitan Division of the Eastern Conference of the National Hockey League (NHL). The club was founded as the Kansas City Scouts in Kansas City, Missouri, in 1974. The Scouts moved to Denver, Colorado in 1976 and became the Colorado Rockies. In 1982, they moved to East Rutherford, New Jersey and took their current name. For their first 25 seasons in New Jersey, the Devils were based at the Meadowlands Sports Complex in East Rutherford and played their home games at Brendan Byrne Arena (later renamed to Continental Airlines Arena). Beginning with the 200708 season, the Devils relocated to Newark and now play their home games at the Prudential Center., In ice hockey, the goaltender is the player responsible for preventing the hockey puck from entering their team's net, thus preventing the opposing team from scoring. The goaltender usually plays in or near the area in front of the net called the "goal crease" (often referred to simply as " the crease" or "the net"). Goaltenders tend to stay at or beyond the top of the crease to cut down on the angle of shots. In today's age of goaltending there are two common styles, butterfly and hybrid (hybrid is a mix of the traditional stand-up style and butterfly technique). Because of the power of shots, the goaltender wears special equipment designed to protect the body from direct impact. The goalie is one of the most valuable players on the ice, as their performance can greatly change the outcome or score of the game. One-on-one situations, such as breakaways and shootouts, have the tendency to highlight a goaltender's pure skill, or lack thereof. Only one goaltender is allowed to be on the ice for each team at any given time., The City of New York, often called New York City or simply New York, is the most populous city in the United States. With an estimated 2015 population of 8,550,405 distributed over a land area of just , New York City is also the most densely populated major city in the United States. Located at the southern tip of the state of New York, the city is the center of the New York metropolitan area, one of the most populous urban agglomerations in the world. A global power city, New York City exerts a significant impact upon commerce, finance, media, art, fashion, research, technology, education, and entertainment, its fast pace defining the term "New York minute". Home to the headquarters of the United Nations, New York is an important center for international diplomacy and has been described as the cultural and financial capital of the world., The New York Islanders are a professional ice hockey team based in New York City. They are members of the Metropolitan Division of the Eastern Conference of the National Hockey League (NHL). The team plays its home games at Barclays Center, located in the borough of Brooklyn. The Islanders are one of three NHL franchises in the New York metropolitan area, along with the New Jersey Devils and New York Rangers, and their primary geographic fan base resides on Long Island., The New York Rangers are a professional ice hockey team based in New York City. They are members of the Metropolitan Division of the Eastern Conference of the National Hockey League (NHL). The team plays its home games at Madison Square Garden, located in the borough of Manhattan. The Rangers are one of three NHL franchises in the New York metropolitan area, along with the New Jersey Devils and New York Islanders. The club is also one of the oldest teams in the NHL, having joined in 1926 as an expansion franchise. They are part of the group of teams referred to as the Original Six, along with the Boston Bruins, Chicago Blackhawks, Detroit Red Wings, Montreal Canadiens and Toronto Maple Leafs. The Rangers were the first NHL franchise in the United States to win the Stanley Cup, which they have done four times, most recently in 199394.
History.
Early years.
George Lewis "Tex" Rickard, president of Madison Square Garden, was awarded an NHL franchise for the 192627 season to compete with the now-defunct New York Americans, who had begun play at the Garden the previous season. The Americans (also known as the "Amerks") proved to be an even greater success than expected during their inaugural season, leading Rickard to pursue a second team for the Garden despite promising the Amerks that they would be the only hockey team to play there. The new team was quickly nicknamed "Tex's Rangers".
Rickard's franchise began play in the 192627 season. The first team crest was a horse sketched in blue carrying a cowboy waving a hockey stick aloft, before being changed to the familiar R-A-N-G-E-R-S in diagonal. Rickard managed to get future legendary Toronto Maple Leafs owner Conn Smythe to assemble the team. However, Smythe had a falling-out with Rickard's hockey man, Col. John S. Hammond, and was fired as manager-coach on the eve of the first seasonhe was paid a then-hefty $2,500 to leave. Smythe was replaced by Pacific Coast Hockey Association co-founder Lester Patrick. The new team Smythe assembled turned out to be a winner. The Rangers won the American Division title their first year but lost to the Boston Bruins in the playoffs., The City of Fort St. John is a city in northeastern British Columbia, Canada. A member municipality of the Peace River Regional District, the city encompasses a total area of about with 18,609 residents at the 2011 census (More than 21,000 by the end of 2015). Located at Mile 47, it is one of the largest cities along the Alaska Highway. Originally established in 1794, as a trading post, Fort St. John is the oldest European-established settlement in present-day British Columbia. Fort St. John is served by the Fort St. John Airport. The municipal slogan is "Fort St. John: The Energetic City"., Ice hockey is a contact team sport played on ice, usually in a rink, in which two teams of skaters use their sticks to shoot a vulcanized rubber puck into their opponent's net to score points. Ice hockey teams usually consist of six players each: one goaltender, and five players who skate up and down the ice trying to take the puck and score a goal against the opposing team., Manhattan is the most densely populated borough of New York City, its economic and administrative center, and the city's historical birthplace. The borough is coextensive with New York County, founded on November 1, 1683, as one of the original counties of the U.S. state of New York. The borough consists mostly of Manhattan Island, bounded by the East, Hudson, and Harlem rivers, and also includes several small adjacent islands and Marble Hill, a small neighborhood on the U.S. mainland., Rouses Point is a village in Clinton County, New York, United States, along the 45th parallel. The population was 2,209 at the 2010 census. The village is named after Jacques Roux, a French Canadian soldier who fought alongside the Americans during the War of Independence. It is on the west shore of the northern end of Lake Champlain, in the northeast part of the town of Champlain. It is north of the city of Plattsburgh and less than one mile south of the CanadaUnited States border., Hubert John Francis `` Frank '' Peters ( June 5 , 1902 -- July 17 , 1973 ) , nicknamed Frosty Peters , was a professional ice hockey player who played 43 games in the National Hockey League . Born in Rouses Point , New York , the son of Hubert Peters , a printer , he played for the New York Rangers . Peters holds a record having played the second most games in the NHL without registering a point , at 44 behind Gord Strate , who played in 61 ., Toronto is the most populous city in Canada, the provincial capital of Ontario, and the centre of the Greater Toronto Area, the most populous metropolitan area in Canada. Growing in population, the 2011 census recorded a population of 2,615,060. As of 2015, the population is now estimated at 2,826,498, making Toronto the fourth-largest city in North America based on the population within its city limits. Toronto trails only Mexico City, New York City, and Los Angeles by this measure, while it is the fifth-largest (behind also Chicago) if ranked by the size of its metropolitan area . An established global city, Toronto is an international centre of business, finance, arts, and culture, and widely recognized as one of the most multicultural and cosmopolitan cities in the world., Gordon Lynn Strate (May 28, 1935  September 5, 2012) was a Canadian professional ice hockey player who played 61 games in the National Hockey League for the Detroit Red Wings as a defenceman. He holds the record as the player to have played the most NHL games without recording a point. After retiring from hockey, he owned a tire shop in Fort St. John, British Columbia and eventually returned to Sherwood Park, Alberta, just outside his home town to retire. He was an active member of The Church of Jesus Christ of Latter-day Saints, and died in Sherwood Park, Alberta at the age of 77., The National Hockey League (NHL) is a professional ice hockey league currently composed of 31 member clubs. Of the 30 clubs currently playing, 23 are in the United States and 7 in Canada. Headquartered in New York City, the NHL is considered to be the premier professional ice hockey league in the world, and one of the major professional sports leagues in the United States and Canada. The Stanley Cup, the oldest professional sports trophy in North America, is awarded annually to the league playoff champion at the end of each season., The Chicago Blackhawks (spelled Black Hawks until 1986, and known colloquially as the Hawks) are a professional ice hockey team based in Chicago, Illinois. They are members of the Central Division of the Western Conference of the National Hockey League (NHL). They have won six Stanley Cup championships since their founding in 1926. The Blackhawks are one of the "Original Six" NHL teams along with the Detroit Red Wings, Montreal Canadiens, Toronto Maple Leafs, Boston Bruins and New York Rangers. Since , the club's home rink is the United Center. The club had previously played for 65 years at Chicago Stadium., Subject: frank peters , Relation: position_played_on_team_/_speciality, Options: (A) center (B) centre (C) defenceman (D) end (E) goaltender
answer:
defenceman


question:
Context: Punta del Este is a city and resort on the Atlantic Coast in the Maldonado Department of southeastern Uruguay. Although the city has a year-round population of about 9,280, the summer tourist boom adds to this a very large number of non-residents. Punta del Este is also the name of the municipality to which the city belongs. It includes Punta del Este proper and Península areas., The Maldonado Department, with an area of and 190,500 inhabitants, is located to the southeast of Uruguay. Its capital is Maldonado., An orchestra is a large instrumental ensemble typical of classical music, which features string instruments such as violin, viola, cello and double bass, as well as brass, woodwinds, and percussion instruments, grouped in sections. Other instruments such as the piano and celesta may sometimes appear in a fifth keyboard section or may stand alone, as may the concert harp and, for performances of some modern compositions, electronic instruments., Uruguay, officially the Oriental Republic of Uruguay, is a country in the southeastern region of South America. It borders Argentina to its west and Brazil to its north and east, with the Río de la Plata (River of Silver) to the south and with the Atlantic Ocean to the southeast. Uruguay is home to an estimated 3.42 million people, of whom 1.8 million live in the metropolitan area of its capital and largest city, Montevideo. With an area of approximately , Uruguay is geographically the second-smallest nation in South America, only larger in size than Suriname., Classical music is art music produced or rooted in the traditions of Western music, including both liturgical (religious) and secular music. While a more accurate term is also used to refer to the period from 1750 to 1820 (the Classical period), this article is about the broad span of time from roughly the 11th century to the present day, which includes the Classical period and various other periods. The central norms of this tradition became codified between 1550 and 1900, which is known as the common-practice period. The major time divisions of Western art music are as follows: 
European art music is largely distinguished from many other non-European and some popular musical forms by its system of staff notation, in use since about the 16th century. Western staff notation is used by composers to indicate to the performer the pitches (e.g., melodies, basslines, chords), tempo, meter and rhythms for a piece of music. This can leave less room for practices such as improvisation and "ad libitum" ornamentation, which are frequently heard in non-European art music and in popular-music styles such as jazz and blues. Another difference is that whereas most popular styles adopt the song (strophic) form, classical music has been noted for its development of highly sophisticated forms of instrumental music such as the concerto, symphony, sonata, and mixed vocal and instrumental styles such as opera which, since they are written down, can sustain larger forms and attain a high level of complexity., Suite Punta del Este is a tango nuevo work for orchestral strings and a bandoneón written by the Argentine composer Ástor Piazzolla in 1982 . Punta del Este is an Uruguayan resort where the artist spent many summers and particularly enjoyed shark fishing . It is broken into 3 movements : I. Introduccion : Allegro pesante II. Coral : Adagio III. Fuga : Allegro vivace . Suite Punta Del Este is a scored for bandoneon ( accordion ) , flute , oboe , clarinet , bassoon and strings . It has been used as a signature theme for the 1995 science fiction film 12 Monkeys as well as a model for music in a scene in The Simpsons episode `` Yokel Chords '' ., Subject: suite punta del este, Relation: instance_of, Options: (A) 1 (B) area (C) city (D) coast (E) country (F) del (G) department (H) metropolitan (I) metropolitan area (J) municipality (K) ocean (L) population (M) region (N) republic (O) resort (P) river (Q) song (R) year
answer:
song


question:
Context: Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, or a red scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin.
Risk factors for developing breast cancer include being female, obesity, lack of physical exercise, drinking alcohol, hormone replacement therapy during menopause, ionizing radiation, early age at first menstruation, having children late or not at all, older age, and family history. About 510% of cases are due to genes inherited from a person's parents, including BRCA1 and BRCA2 among others. Breast cancer most commonly develops in cells from the lining of milk ducts and the lobules that supply the ducts with milk. Cancers developing from the ducts are known as ductal carcinomas, while those developing from lobules are known as lobular carcinomas. In addition, there are more than 18 other sub-types of breast cancer. Some cancers, such as ductal carcinoma in situ, develop from pre-invasive lesions. The diagnosis of breast cancer is confirmed by taking a biopsy of the concerning lump. Once the diagnosis is made, further tests are done to determine if the cancer has spread beyond the breast and which treatments it may respond to.
The balance of benefits versus harms of breast cancer screening is controversial. A 2013 Cochrane review stated that it is unclear if mammographic screening does more good or harm. A 2009 review for the US Preventive Services Task Force found evidence of benefit in those 40 to 70 years of age, and the organization recommends screening every two years in women 50 to 74 years old. The medications tamoxifen or raloxifene may be used in an effort to prevent breast cancer in those who are at high risk of developing it. Surgical removal of both breasts is another preventative measure in some high risk women. In those who have been diagnosed with cancer, a number of treatments may be used, including surgery, radiation therapy, chemotherapy, hormonal therapy and targeted therapy. Types of surgery vary from breast-conserving surgery to mastectomy. Breast reconstruction may take place at the time of surgery or at a later date. In those in whom the cancer has spread to other parts of the body, treatments are mostly aimed at improving quality of life and comfort.
Outcomes for breast cancer vary depending on the cancer type, extent of disease, and person's age. Survival rates in the developed world are high, with between 80% and 90% of those in England and the United States alive for at least 5 years. In developing countries survival rates are poorer. Worldwide, breast cancer is the leading type of cancer in women, accounting for 25% of all cases. In 2012 it resulted in 1.68 million cases and 522,000 deaths. It is more common in developed countries and is more than 100 times more common in women than in men., A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects the lower urinary tract it is known as a bladder infection (cystitis) and when it affects the upper urinary tract it is known as kidney infection (pyelonephritis). Symptoms from a lower urinary tract include pain with urination, frequent urination, and feeling the need to urinate despite having an empty bladder. Symptoms of a kidney infection include fever and flank pain usually in addition to the symptoms of a lower UTI. Rarely the urine may appear bloody. In the very old and the very young, symptoms may be vague or non-specific.
The most common cause of infection is "Escherichia coli", though other bacteria or fungi may rarely be the cause. Risk factors include female anatomy, sexual intercourse, diabetes, obesity, and family history. Although sexual intercourse is a risk factor, UTIs are not classified as sexually transmitted infections (STIs). Kidney infection, if it occurs, usually follows a bladder infection but may also result from a blood-borne infection. Diagnosis in young healthy women can be based on symptoms alone. In those with vague symptoms, diagnosis can be difficult because bacteria may be present without there being an infection. In complicated cases or if treatment fails, a urine culture may be useful.
In uncomplicated cases, UTIs are treated with a short course of antibiotics such as nitrofurantoin or trimethoprim/sulfamethoxazole. Resistance to many of the antibiotics used to treat this condition is increasing. In complicated cases, a longer course or intravenous antibiotics may be needed. If symptoms do not improved in two or three days, further diagnostic testing may be needed. Phenazopyridine may help with symptoms. In those who have bacteria or white blood cells in their urine but have no symptoms, antibiotics are generally not needed, although during pregnancy is an exception. In those with frequent infections, a short course of antibiotics may be taken as soon as symptoms begin or long term antibiotics may be used as a preventative measure.
About 150 million people developed a urinary tract infection each year. They are more common in women than men. In women, they are the most common form of bacterial infection. Up to 10% of women have a urinary tract infection in a given year and half of women having at least one infection at some point in their lives. They occur most frequently between the ages of 16 and 35 years. Recurrences are common. Urinary tract infections have been described since ancient times with the first documented description in the Ebers Papyrus dated to c. 1550 BC.
Signs and symptoms.
Lower urinary tract infection is also referred to as a bladder infection. The most common symptoms are burning with urination and having to urinate frequently (or an urge to urinate) in the absence of vaginal discharge and significant pain. These symptoms may vary from mild to severe and in healthy women last an average of six days. Some pain above the pubic bone or in the lower back may be present. People experiencing an upper urinary tract infection, or pyelonephritis, may experience flank pain, fever, or nausea and vomiting in addition to the classic symptoms of a lower urinary tract infection. Rarely the urine may appear bloody or contain visible pus in the urine., Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Not all tumors are cancerous; benign tumors do not spread to other parts of the body. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss and a change in bowel movements. While these symptoms may indicate cancer, they may have other causes. Over 100 types of cancers affect humans.
Tobacco use is the cause of about 22% of cancer deaths. Another 10% is due to obesity, poor diet, lack of physical activity and drinking alcohol. Other factors include certain infections, exposure to ionizing radiation and environmental pollutants. In the developing world nearly 20% of cancers are due to infections such as hepatitis B, hepatitis C and human papillomavirus (HPV). These factors act, at least partly, by changing the genes of a cell. Typically many genetic changes are required before cancer develops. Approximately 510% of cancers are due to inherited genetic defects from a person's parents. Cancer can be detected by certain signs and symptoms or screening tests. It is then typically further investigated by medical imaging and confirmed by biopsy.
Many cancers can be prevented by not smoking, maintaining a healthy weight, not drinking too much alcohol, eating plenty of vegetables, fruits and whole grains, vaccination against certain infectious diseases, not eating too much processed and red meat, and avoiding too much sunlight exposure. Early detection through screening is useful for cervical and colorectal cancer. The benefits of screening in breast cancer are controversial. Cancer is often treated with some combination of radiation therapy, surgery, chemotherapy, and targeted therapy. Pain and symptom management are an important part of care. Palliative care is particularly important in people with advanced disease. The chance of survival depends on the type of cancer and extent of disease at the start of treatment. In children under 15 at diagnosis the five-year survival rate in the developed world is on average 80%. For cancer in the United States the average five-year survival rate is 66%.
In 2012 about 14.1 million new cases of cancer occurred globally (not including skin cancer other than melanoma). It caused about 8.2 million deaths or 14.6% of human deaths. The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer and stomach cancer. In females, the most common types are breast cancer, colorectal cancer, lung cancer and cervical cancer. If skin cancer other than melanoma were included in total new cancers each year it would account for around 40% of cases. In children, acute lymphoblastic leukaemia and brain tumors are most common except in Africa where non-Hodgkin lymphoma occurs more often. In 2012, about 165,000 children under 15 years of age were diagnosed with cancer. The risk of cancer increases significantly with age and many cancers occur more commonly in developed countries. Rates are increasing as more people live to an old age and as lifestyle changes occur in the developing world. The financial costs of cancer were estimated at $1.16 trillion US dollars per year as of 2010.
Definitions.
Cancers are a large family of diseases that involve abnormal cell growth with the potential to invade or spread to other parts of the body. They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often form a mass or lump, but may be distributed diffusely., Medical imaging is the technique and process of creating visual representations of the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organs and tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging., Gonorrhea, also spelled gonorrhoea, is a sexually transmitted infection caused by the bacterium "Neisseria gonorrhoeae". Many people have no symptoms. Men may have burning with urination, discharge from the penis, or testicular pain. Women may have burning with urination, vaginal discharge, vaginal bleeding between periods, or pelvic pain. Complications in women include pelvic inflammatory disease and in men include inflammation of the epididymis. If untreated gonorrhea can occasionally spread to affect joints or heart valves.
Gonorrhea is spread through sexual contact with an infected person. This includes oral, anal, and vaginal sex. It can also spread from a mother to a child during birth. Diagnosis is by testing the urine, urethra in males, or cervix in females. Testing all women who are sexually active and less than 25 years of age each year as well as those with new sexual partners is recommended. This same recommendation applies in men who have sex with men.
Gonorrhea can be prevented with the use of condoms, having sex with only one person who is uninfected, and by not having sex. Treatment is usually with ceftriaxone by injection and azithromycin by mouth. Resistance has developed to many previously used antibiotics and higher doses of ceftriaxone are occasionally required. Retesting is recommended three months after treatment. Sexual partners from the last 2 months should also be treated.
Gonorrhea affects about 0.8% of women and 0.6% of men. An estimated 33 to 106 million new cases occur each year, out of the 498 million new cases of curable STI  which also includes syphilis, chlamydia, and trichomoniasis. Infections in women most commonly occur when they are young adults. In 2013, it caused about 2,300 deaths, down from 3,200 in 1990. Descriptions of the disease date as far back as the Old Testament., In medicine, hematuria, or haematuria, is the presence of red blood cells (erythrocytes) in the urine. It may be idiopathic and/or benign, or it can be a sign that there is a kidney stone or a tumor in the urinary tract (kidneys, ureters, urinary bladder, prostate, and urethra), ranging from trivial to lethal. If white blood cells are found in addition to red blood cells, then it is a signal of urinary tract infection., Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is therapy using ionizing radiation, generally as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology., Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a category of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). Chemotherapy is one of the major categories of medical oncology (the medical discipline specifically devoted to pharmacotherapy for cancer)., In medicine, specifically urology, dysuria refers to painful urination. Difficult urination is also sometimes, but rarely, described as dysuria., Surgery (from the "cheirourgik" (composed of , "hand", and , "work"), via , meaning "hand work") is an ancient medical specialty that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance or to repair unwanted ruptured areas (for example, a perforated ear drum)., In medicine, a stent is a metal or plastic tube inserted into the lumen of an anatomic vessel or duct to keep the passageway open, and stenting is the placement of a stent. There is a wide variety of stents used for different purposes, from expandable coronary, vascular and biliary stents, to simple plastic stents used to allow the flow of urine between kidney and bladder. Stent is also used as a verb to describe the placement of such a device, particularly when a disease such as atherosclerosis has pathologically narrowed a structure such as an artery. , Prostate cancer, also known as carcinoma of the prostate, is the development of cancer in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, some grow relatively quickly. The cancer cells may spread from the prostate to other parts of the body, particularly the bones and lymph nodes. It may initially cause no symptoms. In later stages it can lead to difficulty urinating, blood in the urine, or pain in the pelvis, back or when urinating. A disease known as benign prostatic hyperplasia may produce similar symptoms. Other late symptoms may include feeling tired due to low levels of red blood cells.
Factors that increase the risk of prostate cancer include: older age, a family history of the disease, and race. About 99% of cases occur in those over the age of 50. Having a first-degree relative with the disease increases the risk two to threefold. In the United States it is more common in the African American population than the white American population. Other factors that may be involved include a diet high in processed meat, red meat, or milk products or low in certain vegetables. An association with gonorrhea has been found, but a reason for this relationship has not been identified. Prostate cancer is diagnosed by biopsy. Medical imaging may then be done to determine if the cancer has spread to other parts of the body.
Prostate cancer screening is controversial. Prostate-specific antigen (PSA) testing increases cancer detection but does not decrease mortality. The United States Preventive Services Task Force recommends against screening using the PSA test, due to the risk of overdiagnosis and overtreatment, as most cancer diagnosed would remain asymptomatic. The USPSTF concludes that the potential benefits of testing do not outweigh the expected harms. While 5-reductase inhibitors appear to decrease low-grade cancer risk they do not affect high-grade cancer risk and thus are not recommended for prevention. Supplementation with vitamins or minerals does not appear to affect the risk.
Many cases can be safely followed with active surveillance or watchful waiting. Other treatments may include a combination of surgery, radiation therapy, hormone therapy or chemotherapy. When it only occurs inside the prostate it may be curable. In those in whom the disease has spread to the bones, pain medications, bisphosphonates and targeted therapy, among others, may be useful. Outcomes depend on a person's age and other health problems as well as how aggressive and extensive the cancer is. Most people with prostate cancer do not end up dying from the disease. The 5-year survival rate in the United States is 99%. Globally it is the second most common type of cancer and the fifth leading cause of cancer-related death in men. In 2012 it occurred in 1.1 million men and caused 307,000 deaths. It was the most common cancer in males in 84 countries, occurring more commonly in the developed world. Rates have been increasing in the developing world. Detection increased significantly in the 1980s and 1990s in many areas due to increased PSA testing. Studies of males who died from unrelated causes have found prostate cancer in 30% to 70% of those over age 60.
Signs and symptoms.
Early prostate cancer usually has no clear symptoms. Sometimes, however, prostate cancer does cause symptoms, often similar to those of diseases such as benign prostatic hyperplasia. These include frequent urination, nocturia (increased urination at night), difficulty starting and maintaining a steady stream of urine, hematuria (blood in the urine), and dysuria (painful urination). A study based on the 1998 Patient Care Evaluation in the US found that about a third of patients diagnosed with prostate cancer had one or more such symptoms, while two-thirds had no symptoms., A prostatic stent is a stent used to keep open the male urethra and allow the passing of urine in cases of prostatic obstruction and lower urinary tract symptoms ( LUTS ) . Prostatic obstruction is a common condition with a variety of etiologies . Benign prostatic hyperplasia ( BPH ) is the most common cause , but obstruction may also occur acutely after treatment for BPH such as transurethral needle ablation of the prostate ( TUNA ) , transurethral resection of the prostate ( TURP ) , transurethral microwave thermotherapy ( TUMT ) , prostate cancer or after radiation therapy ., Medicine (British English ; American English ) is the science and practice of the diagnosis, treatment, and prevention of disease. The word "medicine" is derived from Latin "medicus", meaning "a physician". Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others., Benign prostatic hyperplasia (BPH), also called benign enlargement of the prostate (BEP or BPE), is a noncancerous increase in size of the prostate. BPH involves hyperplasia of prostatic stromal and epithelial cells, resulting in the formation of large, fairly discrete nodules in the transition zone of the prostate. BPH involves hyperplasia (an increase in the number of cells) rather than hypertrophy (a growth in the size of individual cells), but the two terms are often used interchangeably, even among urologists. 
When sufficiently large, the nodules push on and narrow the urethra resulting in an increased resistance to flow of urine from the bladder. This is commonly referred to as "obstruction", although the urethral lumen is no less patent, only compressed. Resistance to urine flow requires the bladder to work harder during voiding, possibly leading to progressive hypertrophy, instability, or weakness (atony) of the bladder muscle. If BPH causes obstruction of the bladder and remains untreated, complications such as recurrent urinary tract infections, bladder stones, and chronic kidney disease (potentially leading to kidney failure) may ensue. 
Several treatment options exist to treat BPH, including lifestyle changes, medications, self-catheterization, and surgery. Urinating while in the sitting position may be helpful. Medications commonly used to relieve obstructive symptoms of BPH include 1-receptor blockers and 5-reductase inhibitors to reduce pressure on the urethra and allow for easier passage of urine. If conservative treatment with lifestyle modifications and medications fails to relieve the obstructive symptoms of BPH, surgical removal of part of the prostate to relieve compression of the urethra is often necessary. Alternative medicine approaches, such as supplementation with saw palmetto, do not appear to be significantly more effective than placebo.
Adenomatous prostatic growth is believed to begin at approximately age 30. An estimated 50% of men have histologic evidence of BPH by age 50 and 75% by age 80; in 4050% of these men, BPH becomes clinically significant. BPH was one of the ten most common and costly diseases in men older than 50 years of age in a study in the United States. Although prostate specific antigen levels may be elevated in men affected by BPH because of increased organ volume and inflammation due to urinary tract infections, BPH does not lead to cancer or increase the risk of cancer., Adjuvant therapy or care, also called adjunct therapy or adjunctive therapy or care, is therapy that is given in addition to the primary, main, or initial therapy to maximize its effectiveness. As an adjuvant agent modifies the effect of another agent, so adjuvant therapy modifies other therapy. The surgeries and complex treatment regimens used in cancer therapy have led the term to be used mainly to describe adjuvant cancer treatments. An example of such adjuvant therapy is the additional treatment usually given after surgery where all detectable disease has been removed, but where there remains a statistical risk of relapse due to occult disease. If known disease is left behind following surgery, then further treatment is not technically adjuvant., Subject: prostatic stent, Relation: medical_specialty, Options: (A) genetics (B) infection (C) oncology (D) pathology (E) surgery (F) urology
answer:

urology