Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: The Rose Experience is the fourth studio album by multi-platinum R&B singer Case.

A: What is the name of the artist or group which originally performed The Rose Experience?
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Q: The All-Russia People's Front (Russian: ), known by its Russian initialism ONF, is a movement in Russia started in 2011 by then-Prime Minister of Russia Vladimir Putin to provide United Russia with ''new ideas, new suggestions and new faces''.

A: Who led All-Russia People's Front?
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Q: Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor B ligand (RANKL) has been identified as a pivotal paracrine mediator of progesterone function in mouse mammary gland development and mammary carcinogenesis. Whether the factor has the same role in humans is of clinical interest because an inhibitor for RANKL, denosumab, is already used for the treatment of bone disease and might benefit breast cancer patients. We show that progesterone receptor (PR) signaling failed to induce RANKL in PR(+) breast cancer cell lines and in dissociated, cultured breast epithelial cells. In clinical specimens from healthy donors and intact breast tissue microstructures, hormone response was maintained and RANKL expression was under progesterone control, which increased RNA stability. RANKL was sufficient to trigger cell proliferation and was required for progesterone-induced proliferation. The findings were validated in vivo where RANKL protein expression in the breast epithelium correlated with serum progesterone levels and the protein was expressed in a subset of luminal cells that express PR. Thus, important hormonal control mechanisms are conserved across species, making RANKL a potential target in breast cancer treatment and prevention.

A:
To the ligand of which receptors does Denosumab (Prolia) bind?
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