Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, demonstrated efficacy and safety in moderate-to-severe plaque psoriasis when administered via subcutaneous injection. Self-administration by pre-filled syringe (PFS) can offer patients clinical benefits of a drug, with increased convenience. To assess efficacy, safety and usability of secukinumab administration via PFS in subjects with moderate-to-severe plaque psoriasis. Subjects in this phase 3 trial were randomized 1:1:1 to secukinumab 300 or 150mg or matching placebo. Results to week 12 are presented here. Each treatment was delivered using a PFS once weekly to week 4, and again at week 8. Co-primary endpoints were secukinumab superiority over placebo for week 12 PASI 75 (75% reduction in Psoriasis Area and Severity Index) and IGA mod 2011 (2011 modified Investigator's Global Assessment) 0/1 response rates. Secondary endpoints included PFS usability, determined by observer rating of successful, hazard-free self-injection and subject rating of acceptability by the Self-Injection Assessment Questionnaire (SIAQ). Co-primary endpoints were met, with demonstration of superiority for each secukinumab dose vs. placebo at week 12 (PASI 75: 759%, 695% and 0% for secukinumab 300mg, 150mg and placebo; IGA mod 2011 0/1: 690%, 525% and 0%, respectively; P<00001 for all comparisons vs. placebo). PFS usability was high: 100% of subjects successfully self-administered treatment at week 1, and subjects reported high SIAQ-assessed acceptability of the PFS throughout the trial. No new/unexpected safety signals were observed. Secukinumab administration by PFS was effective, with an acceptable safety profile and high usability. The PFS provides a reliable, convenient form of secukinumab administration in subjects with moderate-to-severe plaque psoriasis. 
 Question: Which molecule is targeted by a monoclonal antibody Secukinumab?
interleukin-17a

Context: In 1953, 10-year-old Larry Flynt is selling moonshine in Kentucky. Twenty years later, Flynt (Woody Harrelson) and his younger brother, Jimmy (Brett Harrelson) run the Hustler Go-Go club in Cincinnati. With profits down, Flynt decides to publish a newsletter for the club, the first Hustler magazine, with nude pictures of women working at the club. The newsletter soon becomes a full-fledged magazine, but sales are weak. In 1975, after Hustler publishes nude pictures of former first lady Jackie Kennedy Onassis, sales take off.Flynt becomes smitten with Althea Leasure (Courtney Love), a stripper who works at one of his clubs. With Althea and Jimmy's help, Flynt makes a fortune from sales of Hustler. With his success comes enemies - as he finds himself a hated figure of anti-pornography activists. He argues with the activists, saying that "murder is illegal, but if you take a picture of it you may get your name in a magazine or maybe win a Pulitzer Prize". "However", he continues, "sex is legal, but if you take a picture of that act, you can go to jail". He becomes involved in several prominent court cases, and befriends a young lawyer, Alan Isaacman (Edward Norton). In 1975, Flynt loses a smut-peddling court decision in Cincinnati but is released from jail soon afterwards on a technicality. Ruth Carter Stapleton (Hanover), a Christian activist and sister of President Jimmy Carter, seeks out Flynt and urges him to give his life to Jesus. Flynt seems moved and starts letting his newfound religion influence everything in his life, including Hustler content.In 1978, during another trial in Georgia, Flynt and Isaacman are both shot by a man with a rifle while they walk outside a courthouse. Isaacman recovers, but Flynt is paralyzed from the waist down and uses a wheelchair for the rest of his life. Wishing he was dead, Flynt renounces God. Because of the emotional and physical pain, he moves to Beverly Hills, California and spirals down into depression and drug use. During this time, Althea also becomes addicted to painkillers and morphine.In 1983, Flynt undergoes back surgery to deaden several nerves, and as a result, feels rejuvenated. He returns to an active role with the publication, which, in his absence, had been run by Althea and Jimmy. That same year, Flynt is soon in court again for leaking videos relating to the John DeLorean entrapment case, and during his courtroom antics, he fires Isaacman, then throws an orange at the judge. He later wears an American flag as an adult diaper along with an army helmet, and wears T-shirts with provocative messages such as "I Wish I Was Black" and "Fuck This Court." After spitting water at the judge Flynt is sent to a psychiatric ward, where he sinks into depression again. He is diagnosed with having bipolar disorder and forced to take treatment.During this time, Flynt publishes a satirical parody ad in which Christian fundamentalist preacher Jerry Falwell tells of a sexual encounter with his mother. Falwell sues for libel and emotional distress. Flynt countersues for copyright infringement, because Falwell copied his ad. The case goes to trial in December 1984, but the decision is mixed, as Flynt is found guilty of inflicting emotional distress but not libel.By that time, Althea has contracted HIV, which proceeds to AIDS. Some time later in 1987, Flynt finds her dead in the bathtub, having drowned. Flynt presses Isaacman to appeal the Falwell decision to the Supreme Court of the United States. Isaacman refuses, saying Flynt's courtroom antics humiliated him. Flynt pleads with him, saying that he "wants to be remembered for something meaningful". Isaacman agrees and argues the "emotional distress" decision in front of the Supreme Court, in the case Hustler Magazine v. Falwell in 1988. With Flynt in the courtroom, the court overturns the original verdict in a unanimous decision. After the trial, Flynt is alone in his bedroom watching old videotapes of a healthy Althea. 
 Question: What year did Larry Flynt have surgery?
1983

Context: A magnet is an object that attracts certain materials such as iron. Youre probably familiar with common bar magnets, like the one in Figure 24.2. Like all magnets, this bar magnet has north and south poles and attracts objects such as paper clips that contain iron. All magnets have two magnetic poles. The poles are regions where the magnet is strongest. The poles are called north and south because they always line up with Earths north-south axis if the magnet is allowed to move freely. (Earths axis is the imaginary line around which the planet rotates.) What do you suppose would happen if you cut the bar magnet in Figure 24.2 in half along the line between the north and south poles? Both halves would also have north and south poles. If you cut each of the halves in half, all those pieces would have north and south poles as well. Pieces of a magnet always have both north and south poles no matter how many times you cut the magnet. The force that a magnet exerts on certain materials is called magnetic force. Like electric force, magnetic force is exerted over a distance and includes forces of attraction and repulsion. North and south poles of two magnets attract each other, while two north poles or two south poles repel each other. Like the electric field that surrounds a charged particle, a magnetic field surrounds a magnet. This is the area around the magnet where it exerts magnetic force. Figure 24.3 shows the magnetic field surrounding a bar magnet. Tiny bits of iron, called iron filings, were placed under a sheet of glass. When the magnet was placed on the glass, it attracted the iron filings. The pattern of the iron filings shows the lines of force that make up the magnetic field of the magnet. The concentration of iron filings near the poles indicates that these areas exert the strongest force. To see an animated magnetic field of a bar magnet, go to this URL: [Link] When two magnets are brought close together, their magnetic fields interact. You can see how in Figure 24.4. The drawings show how lines of force of north and south poles attract each other whereas those of two north poles repel each other. The animations at the URL below show how magnetic field lines change as two or more magnets move in relation to each other. You can take an animated quiz to check your understanding of magnetic field interactions at this URL: [Link] Magnetism is the ability of a material to be attracted by a magnet and to act as a magnet. No doubt youve handled refrigerator magnets like the ones in Figure 24.5. You probably know first-hand that they stick to a metal refrigerator but not to surfaces such as wooden doors and glass windows. Wood and glass arent attracted to a magnet, whereas the steel refrigerator is. Obviously, only certain materials respond to magnetic force. Magnetism is due to the movement of electrons within atoms of matter. When electrons spin around the nucleus of an atom, it causes the atom to become a tiny magnet, with north and south poles and a magnetic field. In most materials, the electrons orbiting the nuclei of the atoms are arranged in such a way that the materials have no magnetic properties. Also, in most types of matter, the north and south poles of atoms point in all different directions, so overall the matter is not magnetic. Examples of nonmagnetic materials include wood, glass, plastic, paper, copper, and aluminum. These materials are not attracted to magnets and cannot become magnets. In other materials, electrons fill the orbitals of the atoms that make up the material in a way to allow for each atom to have a tiny magnetic field, giving each atom a tiny north and south pole. There are large areas where the north and south poles of atoms are all lined up in the same direction. These areas are called magnetic domains. Generally, the magnetic domains point in different directions, so the material is still not magnetic. However, the material can be magnetized by placing it in a magnetic field. When this happens, all the magnetic domains become aligned, and the material becomes 
 Question: area around a magnet where it exerts force

magnetic field