In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Example Input: Question: The simultaneous expression of IgM and IgD is observed for the first time in lymphocytes: 
 Options:  <1> Early Pro-B. <2> B mature. <3> Late Pro-B. <4> Pre-B. <5> B immature
Example Output: 2

Example Input: Question: What is the mechanism of action of the immunosuppressant drug everolimus ?: 
 Options:  <1> Inhibition of the activation of lymphocytes as membrane receptors. <2> Inhibition of the transmission of the activation signals. <3> Inhibition of nucleotide synthesis. <4> Inhibition of lymphocyte migration. <5> Inhibition of proliferation signals.
Example Output: 5

Example Input: Question: An 8-month-old girl meets diagnostic criteria for hemophagocytic syndrome / hemophagocytic lymphohistiocytosis-fever, hepatosplenomegaly, anemia, thrombocytopenia, hipetransaminasemia, increased sCD25-and has a defect in the capacity of degranulation of her lymphocytes (expression of CD107a). Point out the correct therapeutic attitude in this case: 
 Options:  <1> Quickly initiate HLA typing and immunosuppressive therapy for the donor search (haematopoietic stem cell transplant). <2> Biological treatment with Daclizumab (antiCD25) as the only therapy until the molecular diagnosis of the disease is obtained. <3> Symptomatic and supportive treatment (transfusion of red blood cells and platelets) and avoid any immunosuppressant drug. <4> Broad-spectrum antibiotic therapy via iv for the treatment of an eventual microorganism that triggers hemophagocytosis. <5> Treatment with intravenous gamma globulins, to maintain for life.
Example Output:
1