Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: The Spiritual Exercises of Ignatius of Loyola (Latin original: Exercitia spiritualia) (composed 1522--1524) are a set of Christian meditations, prayers and mental exercises, written by Saint Ignatius of Loyola, a 16th-century Spanish priest, theologian, and founder of the Society of Jesus (Jesuits).

A: What group was Spiritual Exercises of Ignatius of Loyola a member of?
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Q: Alfred Wegener, born in 1880, was a meteorologist and explorer. In 1911, Wegener found a scientific paper that listed identical plant and animal fossils on opposite sides of the Atlantic Ocean. Intrigued, he then searched for and found other cases of identical fossils on opposite sides of oceans. The explanation put out by the scientists of the day was that land bridges had once stretched between these continents. Instead, Wegener pondered the way Africa and South America appeared to fit together like puzzle pieces. Other scientists had suggested that Africa and South America had once been joined, but Wegener was the ideas most dogged supporter. Wegener amassed a tremendous amount of evidence to support his hypothesis that the continents had once been joined. Imagine that youre Wegeners colleague. What sort of evidence would you look for to see if the continents had actually been joined and had moved apart? Here is the main evidence that Wegener and his supporters collected for the continental drift hypothesis: The continents appear to fit together. Ancient fossils of the same species of extinct plants and animals are found in rocks of the same age but are on continents that are now widely separated (Figure 1.1). Wegener proposed that the organisms had lived side by side, but that the lands had moved apart after they were dead and fossilized. His critics suggested that the organisms moved over long-gone land bridges, but Wegener thought that the organisms could not have been able to travel across the oceans. Fossils of the seed fern Glossopteris were too heavy to be carried so far by wind. Mesosaurus was a swimming reptile, but could only swim in fresh water. Cynognathus and Lystrosaurus were land reptiles and were unable to swim. Wegener used fossil evidence to support his continental drift hypothesis. The fos- sils of these organisms are found on lands that are now far apart. Identical rocks, of the same type and age, are found on both sides of the Atlantic Ocean. Wegener said the rocks had formed side by side and that the land had since moved apart. Mountain ranges with the same rock types, structures, and ages are now on opposite sides of the Atlantic Ocean. The Appalachians of the eastern United States and Canada, for example, are just like mountain ranges in eastern Greenland, Ireland, Great Britain, and Norway (Figure 1.2). Wegener concluded that they formed as a single mountain range that was separated as the continents drifted. Grooves and rock deposits left by ancient glaciers are found today on different continents very close to the Equator. This would indicate that the glaciers either formed in the middle of the ocean and/or covered most of the Earth. Today, glaciers only form on land and nearer the poles. Wegener thought that the glaciers were centered over the southern land mass close to the South Pole and the continents moved to their present positions later on. The similarities between the Appalachian and the eastern Greenland mountain ranges are evidences for the continental drift hypothesis. Coral reefs and coal-forming swamps are found in tropical and subtropical environments, but ancient coal seams and coral reefs are found in locations where it is much too cold today. Wegener suggested that these creatures were alive in warm climate zones and that the fossils and coal later drifted to new locations on the continents. Wegener thought that mountains formed as continents ran into each other. This got around the problem of the leading hypothesis of the day, which was that Earth had been a molten ball that bulked up in spots as it cooled (the problem with this idea was that the mountains should all be the same age and they were known not to be). Click image to the left or use the URL below. URL:

A: the coast of south america fits closely to this continent like a puzzle piece.
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Q: In this phase 2 proof-of-concept study we examined the safety and efficacy of selexipag, an orally available, selective prostacyclin receptor (IP receptor) agonist, as a treatment for pulmonary arterial hypertension (PAH). 43 adult patients with symptomatic PAH (receiving stable endothelin receptor antagonist and/or a phosphodiesterase type-5 inhibitor therapy) were randomised three to one to receive either selexipag or placebo. Dosage was up-titrated in 200-g increments from 200 g twice daily on day 1 to the maximum tolerated dose by day 35 (maximum allowed dose of 800 g twice daily). Change in pulmonary vascular resistance at week 17 expressed as a percentage of the baseline value was the primary efficacy end-point, and was analysed in the per protocol set first and then in the all-treated set to assess robustness of results. A statistically significant 30.3% reduction in geometric mean pulmonary vascular resistance was observed after 17 weeks' treatment with selexipag compared with placebo (95% confidence limits -44.7- -12.2; p=0.0045, Wilcoxon rank sum test). This was supported by a similar result from the all-treated set. Selexipag was well tolerated with a safety profile in line with the expected pharmacological effect. Our results encourage the further investigation of selexipag for the treatment of PAH.

A:
Selexipag is used for which disease?
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