Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Input: Consider Input: Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis.

Output: adverse drug event


Input: Consider Input: A literature search conducted to determine the mechanism behind the antagonism of this overdose showed that promethazine interacts with receptors in the central nervous system.

Output: non-adverse drug event


Input: Consider Input: Four cases of adverse experiences with clonidine are described.


Output: adverse drug event