instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Protein kinases (PKs) and lipid kinases (LKs) are good choices for targets of signal transduction therapy as these enzymes are involved in signaling pathways, and are often related to the pathogenesis of lymphoid malignancies. The attractiveness of PKs and LKs as drug able targets is enhanced by the fact that they are enzymes whose biological activity can be turned off by drugs that block their catalytic site. In the last few years small molecular kinase inhibitors (KIs) have been synthesized and become available for preclinical studies and clinical trials. The first KI, introduced into clinical practice in 1998, was imatinib mesylate, which became the first choice drug in chronic myeloid leukemia. More recently, several KIs have been developed to target the proximal B-cell receptor (BCR) signaling pathway including spleen tyrosine kinase inhibitor (Fostamatinib) and Bruton's tyrosine kinase inhibitors (Ibrutinib, AVL-263). These agents are currently evaluated in early clinical trials in chronic lymphocytic leukemia (CLL) and other diseases. Cyclin-dependent kinase (Cdk) inhibitors, flavopiridol (alvocidib), BMS-387032 (SNS-032), sunitinib and sorafenib are currently under evaluation in clinical trials for relapsed/refractory CLL. Multi-tyrosine kinase inhibitors including vandetanib (ZD6474) bosutinib (SKI-606), TKI258 (CHIR-258), pazopanib (GW786034) and axitinib (AG013736) have been also developed for the treatment of lymphoid malignancies. Phosphatidylinositol 3-kinases (PI3K ) are a family of lipid kinases that mediate signals from cell surface receptors. CAL-101 (GS-1101) is an oral PI3K-specific inhibitor which has shown preclinical and clinical activity against CLL. This article summarizes recent achievements in the mechanism of action, pharmacological properties and clinical activity and toxicity of PK and LK inhibitors in CLL.
answer:
What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?


question:
Fevansia is a fungal genus in the family Albatrellaceae.
answer:
Is the taxon rank of Fevansia species or genus?


question:
Fallingwater is a house built over a waterfall in Southwestern Pennsylvania. Frank Lloyd Wright, America's most famous architect, designed the house in 1935. It instantly became famous, and today it is a National Historic Landmark. Guided House Tour This tour features all the major rooms of the house and lasts about one hour. Photography is not permitted during this tour. The Guided House Tour allows children six-year-old and older to enjoy the house with their parents. Adults --$$ 20. 00 with advance purchase. --$$ 23. 00 when purchased on site Youth (ages 6~ 12) -- $$ 14. 00 with advance purchase -- $$ 17. 00 when purchased on site Daily from 10:00 am to 4:00 pm,except Wednesday. In-Depth Tour The tour is best if you desire a greater understanding of what Wright was seeking to create with his masterwork. The number of visitors on each tour is limited and photography is permitted for personal use only. Children nine years and older may accompany adults on this tour. $ 65. 00 per person(Available by advance ticket purchase only) Daily from 10: 00 am to 4: 00 pm Sunset Tour As afternoon turns to evening, the changing light allows you to see Fallingwater from an entirely new perspective. The number of visitors is limited and photography is permitted for personal use only. Children under nine-years-old are not permitted on this tour. $ 110. 00 per person(Available by advance ticket purchase only) May, June, & September-Saturdays at 4:30 p. m. July & August-Fridays and Saturdays at 4:45 p. m. Brunch Tour The guests join their guide for brunch before they leave. Children nine years and older may accompany adults on this tour. Please allow three hours total for this experience. $ 115. 00 per person(Available by advance ticket purchase only) May through September --Saturdays & Sundays at 9:00 a. m
answer:

Where can a couple with an eight-year-old girl make a tour?