In this task, you are given a context, a subject, a relation, and many options. Based on the context, from the options select the object entity that has the given relation with the subject. Answer with text (not indexes).

Example Input: Context: Interscope Records is an American record company. A division of Interscope Geffen A&M Records, its parent company is the Universal Music Group, a subsidiary of Vivendi S.A., Michael Lee Aday (born Marvin Lee Aday, September 27, 1947), better known by his stage name Meat Loaf, is an American musician, singer, songwriter, record producer and actor. He is noted for the "Bat Out of Hell" trilogy of albums, consisting of "Bat Out of Hell", "", and "". "Bat Out of Hell" has sold more than 43 million copies worldwide. Almost 40 years after its release, it still sells an estimated 200,000 copies annually, and stayed on the charts for over nine years, making it one of the best selling albums in history. He is also known for his powerful wide-ranging operatic voice and theatrical live performances., A composer (Latin "compn"; literally "one who puts together") is a person who creates or writes music, which can be vocal music (for a singer or choir), instrumental music (e.g., for solo piano, string quartet, wind quintet or orchestra) or music which combines both instruments and voices (e.g., opera or art song, which is a singer accompanied by a pianist). The core meaning of the term refers to individuals who have contributed to the tradition of Western classical music through creation of works expressed in written musical notation (e.g., sheet music scores)., James Richard "Jim" Steinman (born November 1, 1947) is an American composer, lyricist, and Grammy Award-winning record producer responsible for many hit songs. He has also worked as an arranger, pianist and singer. His work has included songs in the adult contemporary, rock and roll, dance, pop, musical theater and film score genres. Beginning his career in musical theater, Steinman's most notable work in the area includes lyrics for "Whistle Down the Wind" and music for "Tanz der Vampire"., Country music is a genre of United States popular music that originated in the southern United States in the 1920s. It takes its roots from the southeastern genre of United States, such as folk music (especially Appalachian folk music), and blues music. Blues modes have been used extensively throughout its recorded history. Country music often consists of ballads and dance tunes with generally simple forms and harmonies accompanied by mostly string instruments such as banjos, electric and acoustic guitars, dobros and fiddles as well as harmonicas. According to Lindsey Starnes, the term "country music" gained popularity in the 1940s in preference to the earlier term "hillbilly music"; it came to encompass Western music, which evolved parallel to hillbilly music from similar roots, in the mid-20th century. The term "country music" is used today to describe many styles and subgenres. The origins of country music are the folk music of working-class Americans, who blended popular songs, Irish and Celtic fiddle tunes, traditional English ballads, and cowboy songs, and various musical traditions from European immigrant communities. In 2009 country music was the most listened to rush hour radio genre during the evening commute, and second most popular in the morning commute in the United States., `` Read ' Em and Weep '' is a rock music song composed by Jim Steinman . Originally written for Meat Loaf and recorded for his 1981 album , Dead Ringer , the second of only two tracks on the album produced by Steinman and Jimmy Iovine , it did not become a hit until late - 1983 , when a slightly rewritten version was recorded by Barry Manilow as one of three new tracks on his compilation album , Greatest Hits , Vol. II. The Manilow version reached number eighteen on the Billboard Hot 100 and number one on the Adult Contemporary chart . It was Manilow 's last top 40 hit on the Hot 100 ., A record producer or music producer oversees and manages the sound recording and production of a band or performer's music, which may range from recording one song to recording a lengthy concept album. A producer has many roles during the recording process. The roles of a producer vary. He or she may gather musical ideas for the project, collaborate with the artists to select cover tunes or original songs by the artist/group, work with artists and help them to improve their songs, lyrics or arrangements. , Andre Romelle Young (born February 18, 1965), better known by his stage name Dr. Dre, is an American rapper, record producer, and entrepreneur. He is the founder and current CEO of Aftermath Entertainment and Beats Electronics. Dre was previously the co-owner of, and an artist on, Death Row Records. He has produced albums for and overseen the careers of many rappers, including 2Pac, The D.O.C., Snoop Dogg, Eminem, Xzibit, Knoc-turn'al, 50 Cent, The Game and Kendrick Lamar. He is credited as a key figure in the popularization of West Coast G-funk, a style of rap music characterized as synthesizer-based with slow, heavy beats. In 2014, Dr. Dre was ranked as the second richest figure in the American hip hop scene by "Forbes" with a net worth of $550 million; he is at the top of the 2015 "Forbes" list, with an estimated pre-tax take of $620 million in 2014., Rock music is a genre of popular music that originated as "rock and roll" in the United States in the 1950s, and developed into a range of different styles in the 1960s and later, particularly in the United Kingdom and the United States. It has its roots in 1940s' and 1950s' rock and roll, itself heavily influenced by blues, rhythm and blues and country music. Rock music also drew strongly on a number of other genres such as electric blues and folk, and incorporated influences from jazz, classical and other musical sources., A lyricist or lyrist is a person who writes lyricswords for songsas opposed to a composer, who writes the song's melody., Rhythm and blues, often abbreviated as R&B or RnB, is a genre of popular African-American music that originated in the 1940s. The term was originally used by record companies to describe recordings marketed predominantly to urban African Americans, at a time when "urbane, rocking, jazz based music with a heavy, insistent beat" was becoming more popular.
In the commercial rhythm and blues music typical of the 1950s through the 1970s, the bands usually consisted of piano, one or two guitars, bass, drums, saxophone, and sometimes background vocalists. R&B lyrical themes often encapsulate the African-American experience of pain and the quest for freedom and joy. Lyrics focus heavily on the themes of triumphs and failures in terms of relationships, freedom, economics, aspirations, and sex., Bat Out of Hell is the second studio album and the major-label debut by American rock singer Meat Loaf, as well as being his first collaboration with composer Jim Steinman and producer Todd Rundgren, released on October 21, 1977 on Cleveland International/Epic Records. It is one of the best-selling albums of all time, having sold over 43 million copies worldwide. "Rolling Stone" ranked it at number 343 on its list of the 500 greatest albums of all time in 2003., James "Jimmy" Iovine (born March 11, 1953) is an American record and film producer. He is best known as the co-founder of Interscope Records and chairman of Interscope Geffen A&M. In 2006, Iovine teamed with Dr. Dre to found Beats Electronics, a company which produces audio products and operated a now defunct music streaming service. The company was purchased by Apple for $3 billion in May 2014., Subject: read 'em and weep, Relation: record_label, Options: (A) album (B) american record company (C) country music (D) death row records (E) english (F) epic (G) epic records (H) funk (I) interscope geffen a & m (J) interscope records (K) latin (L) melody (M) pop (N) record (O) rock music (P) service (Q) studio album (R) united kingdom (S) universal music group
Example Output: epic records

Example Input: Context: Los Angeles (Spanish for "The Angels"), officially the City of Los Angeles and often known by its initials L.A., is the second-most populous city in the United States (after New York City), the most populous city in California and the county seat of Los Angeles County. Situated in Southern California, Los Angeles is known for its mediterranean climate, ethnic diversity, sprawling metropolis, and as a major center of the American entertainment industry. Los Angeles lies in a large coastal basin surrounded on three sides by mountains reaching up to and over ., Gwen Renée Stefani (born October 3, 1969) is an American singer, songwriter, and fashion designer. She is the co-founder and lead vocalist of the band No Doubt that experienced major success after their breakthrough studio album "Tragic Kingdom" (1995) along with various successful singles, including "Just a Girl", "Don't Speak", "Hey Baby", and "It's My Life". During the band's hiatus, Stefani embarked on a solo pop career in 2004 by releasing her debut studio album "Love. Angel. Music. Baby." Inspired by pop music from the 1980s, the album was met with both critical and commercial success. It spawned three commercially successful singles: "What You Waiting For?", "Rich Girl", and "Hollaback Girl", the latter reached number one on the "Billboard" Hot 100 while also becoming the first US download to sell one million copies. In 2006 Stefani released her second studio album "The Sweet Escape". The album produced two successful singles: "Wind It Up" and the album's title track "The Sweet Escape". Her third solo album "This Is What the Truth Feels Like" was released in March 2016 and became her first solo number-one album on the "Billboard" 200., Jimmy Harry is an American Golden Globe winning songwriter, producer, and multi-instrumentalist who currently resides in Los Angeles, California. Harry has worked with artists such as Madonna, Pink, Weezer, Kylie Minogue, Kelly Clarkson, Fischerspooner, Oh Land, and Santana. Recognized at the 2012 Golden Globes by the Hollywood Foreign Press Association, he won "Best Original Song" with Madonna and Julie Frost for the song "Masterpiece". In 2010 his production of Pink's "Sober" was nominated for a Grammy for "Best Female Pop Vocal Performance", and he also wrote and produced "Funhouse", the title track of her release nominated in the category "Best Pop Album". Jimmy received recognition from the Academy of Canadian Cinema & Television at the 2014 Canadian Screen Awards where he and Serena Ryder won "Best Original Song" for the song "It's No Mistake" from the film "The Right Kind of Wrong"., Kelly Brianne Clarkson (born April 24, 1982) is an American singer, songwriter, actress and author. She rose to fame in 2002 after winning the first season of "American Idol", and has since been referred to as the "Original American Idol" and the "Queen of Covers". She also became the runner-up of "World Idol" the following year. Signing with RCA Records, Clarkson released her debut single, "A Moment Like This", which topped the "Billboard" Hot 100 chart and became the best-selling single of 2002 in the United States. Her debut studio album, "Thankful" (2003), debuted at number one on the "Billboard" 200 and was certified double platinum by the Recording Industry Association of America (RIAA). Its lead single, "Miss Independent", was a top-ten hit in various nations., California is the most populous state in the United States and the third most extensive by area. Located on the western (Pacific Ocean) coast of the U.S., California is bordered by the other U.S. states of Oregon, Nevada, and Arizona and shares an international border with the Mexican state of Baja California. The state capital is Sacramento. Los Angeles is California's most populous city, and the country's second largest after New York City. The state also has the nation's most populous county, Los Angeles County, and its largest county by area, San Bernardino County., A composer (Latin "compn"; literally "one who puts together") is a person who creates or writes music, which can be vocal music (for a singer or choir), instrumental music (e.g., for solo piano, string quartet, wind quintet or orchestra) or music which combines both instruments and voices (e.g., opera or art song, which is a singer accompanied by a pianist). The core meaning of the term refers to individuals who have contributed to the tradition of Western classical music through creation of works expressed in written musical notation (e.g., sheet music scores)., Pop rock is rock music with a lighter, smoother approach that is more reminiscent of commercial pop music. Originating in the 1950s as an alternative to rock and roll, early pop rock was influenced by the beat, arrangements, and style of rock and roll (and sometimes doo wop), but placed a greater emphasis on professional songwriting and recording craft. The detractors of pop rock often deride it as a slick, commercial product, less authentic than rock music., Serena Ryder (born December 8, 1982) is a Canadian musician. Born in Toronto, she grew up in Millbrook, Ontario. Ryder first gained national recognition with her ballad "Weak in the Knees" in 2007. An accomplished songwriter and musician, she also possesses a three-octave vocal range and is considered a mezzo-soprano. Her timbre has been described as slightly nasal with a raspy lower register., Power pop is a popular musical genre that draws its inspiration from 1960s British and American rock music. It typically incorporates a combination of musical devices such as strong melodies, clear vocals and crisp vocal harmonies, economical arrangements and prominent guitar riffs. Instrumental solos are usually kept to a minimum, and blues elements are largely downplayed., Singer-songwriters are musicians who write, compose, and perform their own musical material, including lyrics and melodies., Weezer is an American rock band formed in Los Angeles in 1992, consisting of Rivers Cuomo (lead vocals, guitar), Patrick Wilson (drums), Brian Bell (guitar, backing vocals, keyboards), and Scott Shriner (bass guitar, backing vocals). Weezer has sold 9.2 million albums in the US and over 17 million worldwide., No Doubt is an American rock band from Anaheim, California, that formed in 1986. Since 1994, the group has consisted of vocalist Gwen Stefani, bassist and keyboardist Tony Kanal, guitarist and keyboardist Tom Dumont, and drummer Adrian Young. Since the mid-1990s in live performances and the studio, they have been supported by keyboardist and trombonist Gabrial McNair and keyboardist and trumpeter Stephen Bradley., Reggae is a music genre that originated in Jamaica in the late 1960s. The term also denotes the modern popular music of Jamaica and its diaspora. A 1968 single by Toots and the Maytals "Do the Reggay" was the first popular song to use the word "reggae," effectively naming the genre and introducing it to a global audience. While sometimes used in a broad sense to refer to most types of popular Jamaican dance music, the term "reggae" more properly denotes a particular music style that was strongly influenced by traditional mento as well as American jazz and rhythm and blues, especially the New Orleans R&B practiced by Fats Domino and Allen Toussaint, and evolved out of the earlier genres ska and rocksteady. Reggae usually relates news, social gossip, and political comment. Reggae spread into a commercialized jazz field, being known first as Rudie Blues, then Ska, later Blue Beat, and Rock Steady. It is instantly recognizable from the counterpoint between the bass and drum downbeat, and the offbeat rhythm section. The immediate origins of reggae were in ska and rock steady; from the latter, reggae took over the use of the bass as a percussion instrument., Elan Atias (born September 21, 1975) is an American Jewish, singer/songwriter, reggae singer., Fischerspooner is an electroclash duo and performance troupe formed in 1998 in New York City. The name is a combination of the founders' last names, Warren Fischer and Casey Spooner. Influenced by retro electropop tendencies (arguably similar to Kraftwerk, early Pet Shop Boys, and Gary Numan) Fischerspooner uses a modern approach to programming., Kylie Ann Minogue, OBE (born 28 May 1968), often known simply as Kylie, is an Australian singer, songwriter, dancer and actress. She achieved recognition starring in the Australian soap opera "Neighbours", where she played tomboy mechanic Charlene Robinson. Appearing in the series for two years, Minogue's character married Scott Robinson (Jason Donovan) in an episode viewed by nearly 20 million people in the United Kingdom making it one of the most watched Australian TV episodes ever. Since then, Minogue has been a recording artist and has achieved commercial success and critical acclaim in the entertainment industry. Minogue has been recognised with several honorific nicknames including "Princess of Pop" and "Goddess of Pop". She is recognised as the highest-selling Australian artist of all time by the Australian Recording Industry Association (ARIA)., The Hollywood Foreign Press Association (HFPA) is a non-profit organization of journalists and photographers that reports on the entertainment industry activity and interests in the United States for information outlets (newspaper, magazine and book publication, television and radio broadcasting) predominantly outside the U.S. The HFPA consists of about 90 members from approximately 55 countries with a combined following of more than 250 million. It conducts the annual Golden Globe Awards ceremony in Los Angeles every January that honor notable examples of cinema and television and achievements in entertainment businesses., Tony Ashwin Kanal (born 27 August 1970) is a British-American musician, record producer and songwriter. Kanal is the bassist for the American rock band No Doubt. His musical work outside of the band includes producing and songwriting with artists such as reggae singer Elan Atias and No Doubt bandmate Gwen Stefani, among others., Kara Elizabeth DioGuardi (born December 9, 1970) is an American singer-songwriter, record producer, music publisher, A&R executive, composer and TV personality. She writes music primarily in the pop rock genre. DioGuardi has worked with many popular artists; sales of albums on which her songs appear exceed 160 million worldwide. DioGuardi is a Grammy and Emmy-nominated writer. She's a 2011 NAMM Music For Life Award winner, 2009 NMPA Songwriter Icon Award winner, 2007 BMI Pop Songwriter of the Year, and has received 20 BMI Awards for co-writing the most performed songs on the radio., `` Sober '' is a song by the American singer - songwriter Pink , taken from her fifth studio album , Funhouse ( 2008 ) . It was written by Pink and Kara DioGuardi , with additional writing by Nate `` Danja '' Hills and Marcella Araica , while production was done by Danja , Tony Kanal and Jimmy Harry . The song was released as the album 's second single on October 31 , 2008 , firstly through digital download and later was added to U.S. radio stations on December 1 , 2008 . The power pop song talks about the quiet sense of comfort in being sober , with the singer claiming it was about the vices that we choose . The song received generally favorable reviews from music critics , who commended the track for being a heartfelt track , with some praising its lyrical content . However , few critics dismissed the track , calling it `` more of the same '' from her previous music . Furthermore , the song received a Grammy Award for Best Female Pop Vocal Performance in 2010 . Commercially , `` Sober '' attained success on the charts , reaching the top - ten in over thirteen countries , while reaching the top - twenty in the U.S. , as well as the top of Billboard 's Adult Top 40 chart . A music video for the track was directed by Jonas Akerlund and it finds Pink at a party with her doppelgänger . ``, Blues is a genre and musical form originated by African Americans in the Deep South of the United States around the end of the 19th century. The genre developed from roots in African musical traditions, African-American work songs and European-American folk music. Blues incorporated spirituals, work songs, field hollers, shouts, chants, and rhymed simple narrative ballads. The blues form, ubiquitous in jazz, rhythm and blues and rock and roll, is characterized by the call-and-response pattern, the blues scale and specific chord progressions, of which the twelve-bar blues is the most common. Blue notes (or "worried notes"), usually thirds or fifths flattened in pitch, are also an essential part of the sound. Blues shuffles or walking bass reinforce the trance-like rhythm and form a repetitive effect known as the groove., Subject: sober , Relation: genre, Options: (A) album (B) ballad (C) blues (D) book (E) country (F) dance (G) electroclash (H) electropop (I) entertainment (J) fashion (K) genre (L) information (M) instrumental (N) jazz (O) magazine (P) march (Q) music (R) musical (S) news (T) opera (U) pop rock (V) power pop (W) reggae (X) rhythm (Y) rhythm and blues (Z) rock ([) rock and roll (\) ska (]) soap opera (^) song (_) television (`) vocal music (a) western
Example Output: pop rock

Example Input: Context: A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist involving extraction of sample cells or tissues for examination to determine the presence or extent of a disease. The tissue is generally examined under a microscope by a pathologist, and can also be analyzed chemically. When an entire lump or suspicious area is removed, the procedure is called an excisional biopsy. When only a sample of tissue is removed with preservation of the histological architecture of the tissues cells, the procedure is called an incisional biopsy or core biopsy. When a sample of tissue or fluid is removed with a needle in such a way that cells are removed without preserving the histological architecture of the tissue cells, the procedure is called a needle aspiration biopsy. Biopsies are most commonly performed for insight into possible cancerous and inflammatory conditions., Colorectal cancer (CRC), also known as bowel cancer, is the development of cancer from the colon or rectum (parts of the large intestine). A cancer is the abnormal growth of cells that have the ability to invade or spread to other parts of the body. Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, and feeling tired all the time.
Most colorectal cancers are due to old age and lifestyle factors with only a small number of cases due to underlying genetic disorders. Some risk factors include diet, obesity, smoking, and lack of physical activity. Dietary factors that increase the risk include red and processed meat as well as alcohol. Another risk factor is inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Some of the inherited genetic disorders that can cause colorectal cancer include familial adenomatous polyposis and hereditary non-polyposis colon cancer; however, these represent less than 5% of cases. It typically starts as a benign tumor, often in the form of a polyp, which over time becomes cancerous.
Bowel cancer may be diagnosed by obtaining a sample of the colon during a sigmoidoscopy or colonoscopy. This is then followed by medical imaging to determine if the disease has spread. Screening is effective for preventing and decreasing deaths from colorectal cancer. Screening is recommended starting from the age of 50 to 75. During colonoscopy, small polyps may be removed if found. If a large polyp or tumor is found, a biopsy may be performed to check if it is cancerous. Aspirin and other non-steroidal anti-inflammatory drugs decrease the risk. Their general use is not recommended for this purpose, however, due to side effects.
Treatments used for colorectal cancer may include some combination of surgery, radiation therapy, chemotherapy and targeted therapy. Cancers that are confined within the wall of the colon may be curable with surgery while cancer that has spread widely are usually not curable, with management being directed towards improving quality of life and symptoms. Five year survival rates in the United States are around 65%. This, however, depends on how advanced the cancer is, whether or not all the cancer can be removed with surgery, and the person's overall health. Globally, colorectal cancer is the third most common type of cancer making up about 10% of all cases. In 2012, there were 1.4 million new cases and 694,000 deaths from the disease. It is more common in developed countries, where more than 65% of cases are found. It is less common in women than men., Medical imaging is the technique and process of creating visual representations of the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organs and tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging., The National Football League (NFL) is a professional American football league consisting of 32 teams, divided equally between the National Football Conference (NFC) and the American Football Conference (AFC). The NFL is one of the four major professional sports leagues in North America, and the highest professional level of American football in the world. The NFL's 17-week regular season runs from the week after Labor Day to the week after Christmas, with each team playing 16 games and having one bye week. Following the conclusion of the regular season, six teams from each conference (four division winners and two wild card teams) advance to the playoffs, a single-elimination tournament culminating in the Super Bowl, played between the champions of the NFC and AFC., Non-Hodgkin lymphoma (NHL) is a group of blood cancers that includes all types of lymphoma except Hodgkin's lymphomas. Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and feeling tired. Other symptoms may include bone pain, chest pain, or itchiness. Some forms are slow growing while others are fast growing.
Lymphomas are types of cancer that develops from lymphocytes, a type of white blood cell. Risk factors include poor immune function, autoimmune diseases, "Helicobacter pylori" infection, hepatitis C, obesity, and "Epstein-Barr virus" infection. The World Health Organization (WHO) classifies lymphomas into five major groups, including one for Hodgkin's lymphoma. Within the four groups for NHL there are over 60 specific types of lymphoma. Diagnosis is by examination of a bone marrow or lymph node biopsy. Medical imaging is done to help with cancer staging.
Treatment depends on if the lymphoma is slow or fast growing and if it is in one area or many areas. Treatments may include chemotherapy, radiation, immunotherapy, targeted therapy, stem cell transplantation, surgery, or watchful waiting. If the blood becomes overly thick due to antibodies, plasmapheresis may be used. Radiation and some chemotherapy, however, increase the risk of other cancers, heart disease or nerve problems over the subsequent decades.
In 2013 about 2.96 million people had non-Hodgkin lymphoma and 226,000 died. In the United States 2.1% of people are affected at some point in their life. The most common age of diagnosis is between 65 to 75 years old. The percentage of people who survive five years in the United States is 71%., Stomach cancer, also known as gastric cancer, is cancer developing from the lining of the stomach. Early symptoms may include heartburn, upper abdominal pain, nausea and loss of appetite. Later signs and symptoms may include weight loss, yellowing of the skin and whites of the eyes, vomiting, difficulty swallowing, and blood in the stool among others. The cancer may spread from the stomach to other parts of the body, particularly the liver, lungs, bones, lining of the abdomen and lymph nodes.
The most common cause is infection by the bacterium "Helicobacter pylori", which accounts for more than 60% of cases. Certain types of "H. pylori" have greater risks than others. Other common causes include eating pickled vegetables and smoking. About 10% of cases run in families and between 1% and 3% of cases are due to genetic syndromes inherited from a person's parents such as hereditary diffuse gastric cancer. Most cases of stomach cancers are gastric carcinomas. This type can be divided into a number of subtypes. Lymphomas and mesenchymal tumors may also develop in the stomach. Most of the time, stomach cancer develops in stages over years. Diagnosis is usually by biopsy done during endoscopy. This is followed by medical imaging to determine if the disease has spread to other parts of the body. Japan and South Korea, two countries that have high rates of the disease, screen for stomach cancer.
A Mediterranean diet lowers the risk of cancer as does the stopping of smoking. There is tentative evidence that treating "H. pylori" decreases the future risk. If cancer is treated early, many cases can be cured. Treatments may include some combination of surgery, chemotherapy, radiation therapy, and targeted therapy. If treated late, palliative care may be advised. Outcomes are often poor with a less than 10% 5-year survival rate globally. This is largely because most people with the condition present with advanced disease. In the United States 5-year survival is 28% while in South Korea it is over 65% partly due to screening efforts.
Globally stomach cancer is the fifth leading cause of cancer and the third leading cause of death from cancer making up 7% of cases and 9% of deaths. In 2012 it occurred in 950,000 people and caused 723,000 deaths. Before the 1930s in much of the world, including most Western developed countries, it was the most common cause of death from cancer. Rates of death have been decreasing in many areas of the world since then. This is believed to be due to the eating of less salted and pickled foods as a result of the development of refrigeration as a method of keeping food fresh. Stomach cancer occurs most commonly in East Asia and Eastern Europe. It occurs twice as often in males as in females., Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, due to a mean loss of fluid, body fat or adipose tissue and/or lean mass, namely bone mineral deposits, muscle, tendon, and other connective tissue. Weight loss can either occur unintentionally due to malnourishment or an underlying disease or arise from a conscious effort to improve an actual or perceived overweight or obese state. "Unexplained" weight loss that is not caused by reduction in calorific intake or exercise is called cachexia and may be a symptom of a serious medical condition. Intentional weight loss is commonly referred to as slimming., The Pittsburgh Steelers are a professional American football team based in Pittsburgh, Pennsylvania. The Steelers compete in the National Football League (NFL), as a member club of the league's American Football Conference (AFC) North division. Founded in , the Steelers are the oldest franchise in the AFC., The five-year survival rate is a type of survival rate for estimating the prognosis of a particular disease, normally calculated from the point of diagnosis. Lead time bias from earlier diagnosis can affect interpretation of the five-year survival rate., Surgery (from the "cheirourgik" (composed of , "hand", and , "work"), via , meaning "hand work") is an ancient medical specialty that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance or to repair unwanted ruptured areas (for example, a perforated ear drum)., Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is therapy using ionizing radiation, generally as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology., The Denver Broncos are an American football team based in Denver, Colorado. The Broncos compete in the National Football League (NFL) as a member club of the league's American Football Conference (AFC) West division. The team began play in 1960 as a charter member of the American Football League (AFL) and joined the NFL as part of the merger in 1970. The Broncos are owned by the Pat Bowlen trust. The Broncos have played at Sports Authority Field at Mile High since , after previously playing at Mile High Stadium from 1960 to 2000., Targeted therapy or molecularly targeted therapy is one of the major modalities of medical treatment (pharmacotherapy) for cancer, others being hormonal therapy and cytotoxic chemotherapy. As a form of molecular medicine, targeted therapy blocks the growth of cancer cells by interfering with specific targeted molecules needed for carcinogenesis and tumor growth, rather than by simply interfering with all rapidly dividing cells (e.g. with traditional chemotherapy). Because most agents for targeted therapy are biopharmaceuticals, the term "biologic therapy" is sometimes synonymous with "targeted therapy" when used in the context of cancer therapy (and thus distinguished from chemotherapy, that is, cytotoxic therapy). However, the modalities can be combined; antibody-drug conjugates combine biologic and cytotoxic mechanisms into one targeted therapy., Cervical cancer is a cancer arising from the cervix. It is due to the abnormal growth of cells that have the ability to invade or spread to other parts of the body. Early on, typically no symptoms are seen. Later symptoms may include abnormal vaginal bleeding, pelvic pain, or pain during sexual intercourse. While bleeding after sex may not be serious, it may also indicate the presence of cervical cancer.
Human papillomavirus (HPV) infection appears to be involved in the development of more than 90% of cases; most people who have had HPV infections, however, do not develop cervical cancer. Other risk factors include smoking, a weak immune system, birth control pills, starting sex at a young age, and having many sexual partners, but these are less important. Cervical cancer typically develops from precancerous changes over 10 to 20 years. About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. Diagnosis is typically by cervical screening followed by a biopsy. Medical imaging is then done to determine whether or not the cancer has spread.
HPV vaccines protect against between two and seven high-risk strains of this family of viruses and may prevent up to 90% of cervical cancers. As a risk of cancer still exists, guidelines recommend continuing regular Pap smears. Other methods of prevention include: having few or no sexual partners and the use of condoms. Cervical cancer screening using the Pap smear or acetic acid can identify precancerous changes which when treated can prevent the development of cancer. Treatment of cervical cancer may consist of some combination of surgery, chemotherapy, and radiotherapy. Five year survival rates in the United States are 68%. Outcomes, however, depend very much on how early the cancer is detected.
Worldwide, cervical cancer is both the fourth-most common cause of cancer and the fourth-most common cause of death from cancer in women. In 2012, an estimated 528,000 cases of cervical cancer occurred, with 266,000 deaths. This is about 8% of the total cases and total deaths from cancer. About 70% of cervical cancers occur in developing countries. In low-income countries, it is the most common cause of cancer death. In developed countries, the widespread use of cervical screening programs has dramatically reduced rates of cervical cancer. In medical research, the most famous cell line known as HeLa was developed from cervical cancer cells of a woman named Henrietta Lacks., A benign tumor is a mass of cells (tumor) that lacks the ability to invade neighboring tissue or metastasize. These characteristics are required for a tumor to be defined as cancerous and therefore benign tumors are non-cancerous. Also, benign tumors generally have a slower growth rate than malignant tumors and the tumor cells are usually more differentiated (cells have normal features). Benign tumors are typically surrounded by an outer surface (fibrous sheath of connective tissue) or remain with the epithelium. Common examples of benign tumors include moles and uterine fibroids., A brain tumor or intracranial neoplasm occurs when abnormal cells form within the brain. There are two main types of tumors: malignant or cancerous tumors and benign tumors. Cancerous tumors can be divided into primary tumors that start within the brain, and secondary tumors that have spread from somewhere else, known as brain metastasis tumors. All types of brain tumors may produce symptoms that vary depending on the part of the brain involved. These symptoms may include headaches, seizures, problem with vision, vomiting, and mental changes. The headache is classically worse in the morning and goes away with vomiting. More specific problems may include difficulty in walking, speaking, and with sensation. As the disease progresses unconsciousness may occur.
The cause of most brain tumors is unknown. Uncommon risk factors include inherited neurofibromatosis, exposure to vinyl chloride, EpsteinBarr virus, and ionizing radiation. The evidence for mobile phones is not clear. The most common types of primary tumors in adults are meningiomas (usually benign), and astrocytomas such as glioblastomas. In children, the most common type is a malignant medulloblastoma. Diagnosis is usually by medical examination along with computed tomography or magnetic resonance imaging. This is then often confirmed by a biopsy. Based on the findings, the tumors are divided into different grades of severity.
Treatment may include some combination of surgery, radiation therapy and chemotherapy. Anticonvulsant medication may be needed if seizures occur. Dexamethasone and furosemide may be used to decrease swelling around the tumor. Some tumors grow gradually, requiring only monitoring and possibly needing no further intervention. Treatments that use a person's immune system are being studied. Outcome varies considerably depending on the type of tumor and how far it has spread at diagnosis. Glioblastomas usually have poor outcomes while meningiomas usually have good outcomes. The average five-year survival rate for brain cancer in the United States is 33%.
Secondary or metastatic brain tumors are more common than primary brain tumors, with about half of metastases coming from lung cancer. Primary brain tumors occur in around 250,000 people a year globally, making up less than 2% of cancers. In children younger than 15, brain tumors are second only to acute lymphoblastic leukemia as a cause of cancer. In Australia the average economic cost of a case of brain cancer is $1.9 million, the greatest of any type of cancer., Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver. During the initial infection people often have mild or no symptoms. Occasionally a fever, dark urine, abdominal pain, and yellow tinged skin occurs. The virus persists in the liver in about 75% to 85% of those initially infected. Early on chronic infection typically has no symptoms. Over many years however, it often leads to liver disease and occasionally cirrhosis. In some cases, those with cirrhosis will develop complications such as liver failure, liver cancer, or esophageal and gastric varices.
HCV is spread primarily by blood-to-blood contact associated with intravenous drug use, poorly sterilized medical equipment, needlestick injuries in healthcare, and transfusions. Using blood screening, the risk from a transfusion is less than one per two million. It may also be spread from an infected mother to her baby during birth. It is not spread by superficial contact. It is one of five known hepatitis viruses: A, B, C, D, and E. Diagnosis is by blood testing to look for either antibodies to the virus or its RNA. Testing is recommended in all people who are at risk.
There is no vaccine against hepatitis C. Prevention includes harm reduction efforts among people who use intravenous drugs and testing donated blood. Chronic infection can be cured about 90% of the time with treatments that include the medications sofosbuvir or simeprevir. Previous to this a combination of peginterferon and ribavirin was used which had a cure rate around 50% and greater side effects. Getting access to the newer treatments however can be expensive. Those who develop cirrhosis or liver cancer may require a liver transplant. Hepatitis C is the leading reason for liver transplantation, though the virus usually recurs after transplantation.
An estimated 130200 million people worldwide are infected with hepatitis C. In 2013 about 11 million new cases occurred. It occurs most commonly in Africa and Central and East Asia. About 343,000 deaths due to liver cancer and 358,000 deaths due to cirrhosis occurred in 2013 due to hepatitis C. The existence of hepatitis C  originally identifiable only as a type of non-A non-B hepatitis  was suggested in the 1970s and proven in 1989. Hepatitis C infects only humans and chimpanzees., Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health. People are generally considered obese when their body mass index (BMI), a measurement obtained by dividing a person's weight by the square of the person's height, is over , with the range defined as overweight. Some East Asian countries use lower values. Obesity increases the likelihood of various diseases, particularly heart disease, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis.
Obesity is most commonly caused by a combination of excessive food intake, lack of physical activity, and genetic susceptibility. A few cases are caused primarily by genes, endocrine disorders, medications, or mental illness. The view that obese people eat little yet gain weight due to a slow metabolism is not generally supported. On average, obese people have a greater energy expenditure than their thin counterparts due to the energy required to maintain an increased body mass.
Obesity is mostly preventable through a combination of social changes and personal choices. Changes to diet and exercising are the main treatments. Diet quality can be improved by reducing the consumption of energy-dense foods, such as those high in fat and sugars, and by increasing the intake of dietary fiber. Medications may be taken, along with a suitable diet, to reduce appetite or decrease fat absorption. If diet, exercise, and medication are not effective, a gastric balloon or surgery may be performed to reduce stomach volume or bowel length, leading to feeling full earlier or a reduced ability to absorb nutrients from food.
Obesity is a leading preventable cause of death worldwide, with increasing rates in adults and children. In 2014, 600 million adults (13%) and 42 million children under the age of five were obese. Obesity is more common in women than men. Authorities view it as one of the most serious public health problems of the 21st century. Obesity is stigmatized in much of the modern world (particularly in the Western world), though it was seen as a symbol of wealth and fertility at other times in history and still is in some parts of the world. In 2013, the American Medical Association classified obesity as a disease., Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) which affects the liver. It can cause both acute and chronic infections. Many people have no symptoms during the initial infection. Some develop a rapid onset of sickness with vomiting, yellowish skin, tiredness, dark urine and abdominal pain. Often these symptoms last a few weeks and rarely does the initial infection result in death. It may take 30 to 180 days for symptoms to begin. In those who get infected around the time of birth 90% develop chronic while less than 10% of those infected after the age of five do. Most of those with chronic disease have no symptoms; however, cirrhosis and liver cancer may eventually develop. These complications result in the death of 15 to 25% of those with chronic disease.
The virus is transmitted by exposure to infectious blood or body fluids. Infection around the time of birth or from contact with other people's blood during childhood is the most frequent method by which hepatitis B is acquired in areas where the disease is common. In areas where the disease is rare, intravenous drug use and sexual intercourse are the most frequent routes of infection. Other risk factors include working in healthcare, blood transfusions, dialysis, living with an infected person, travel in countries where the infection rate is high, and living in an institution. Tattooing and acupuncture led to a significant number of cases in the 1980s; however, this has become less common with improved sterility. The viruses cannot be spread by holding hands, sharing eating utensils, kissing, hugging, coughing, sneezing, or breastfeeding. The infection can be diagnosed 30 to 60 days after exposure. The diagnosis is usually confirmed by testing the blood for parts of the virus and for antibodies against the virus. It is one of five known hepatitis viruses: A, B, C, D, and E.
The infection has been preventable by vaccination since 1982. Vaccination is recommended by the World Health Organization in the first day of life if possible. Two or three more doses are required at a later time for full effect. This vaccine works about 95% of the time. About 180 countries gave the vaccine as part of national programs as of 2006. It is also recommended that all blood be tested for hepatitis B before transfusion and condoms be used to prevent infection. During an initial infection, care is based on the symptoms that a person has. In those who develop chronic disease, antiviral medication such as tenofovir or interferon may be useful; however, these drugs are expensive. Liver transplantation is sometimes used for cirrhosis.
About a third of the world population has been infected at one point in their lives, including 240 million to 350 million who have chronic infections. Another 129 million new infections occurred in 2013. Over 750,000 people die of hepatitis B each year. About 300,000 of these are due to liver cancer. The disease is now only common in East Asia and sub-Saharan Africa where between 5 and 10% of adults are chronically infected. Rates in Europe and North America are less than 1%. It was originally known as "serum hepatitis". Research is looking to create foods that contain HBV vaccine. The disease may affect other great apes as well.
Signs and symptoms.
Acute infection with virus is associated with acute viral hepatitis, an illness that begins with general ill-health, loss of appetite, nausea, vomiting, body aches, mild fever, and dark urine, and then progresses to development of jaundice. It has been noted that itchy skin has been an indication as a possible symptom of all hepatitis virus types. The illness lasts for a few weeks and then gradually improves in most affected people. A few people may have a more severe form of liver disease known as (fulminant hepatic failure) and may die as a result. The infection may be entirely asymptomatic and may go unrecognized., The New York Giants are a professional American football team located in the New York metropolitan area. The Giants compete in the National Football League (NFL) as a member club of the league's National Football Conference (NFC) East division. The team plays its home games in East Rutherford, New Jersey, at MetLife Stadium, which it shares with the New York Jets in a unique arrangement. The Giants hold their summer training camp at the Quest Diagnostics Training Center at the Meadowlands Sports Complex., Lymphoma is a group of blood cell tumors that develop from lymphocytes (a type of white blood cell). The name often refers to just the cancerous ones rather than all such tumors. Signs and symptoms may include enlarged lymph nodes, fever, drenching sweats, unintended weight loss, itching, and constantly feeling tired. The enlarged lymph nodes are usually painless. The sweats are most common at night.
There are dozens of subtypes of lymphomas. The two main categories of lymphomas are Hodgkin's lymphomas (HL) and the non-Hodgkin lymphomas (NHL). The World Health Organization (WHO) includes two other categories as types of lymphoma: multiple myeloma and immunoproliferative diseases. About 90% of lymphomas are non-Hodgkin lymphomas. Lymphomas and leukemias are a part of the broader group of tumors of the hematopoietic and lymphoid tissues.
Risk factors for Hodgkin lymphoma include infection with EpsteinBarr virus and a history of the disease in the family. Risk factors for common types of non-Hodgkin lymphomas include autoimmune diseases, HIV/AIDS, infection with human T-lymphotropic virus, immunosuppressant medications, and some pesticides. Eating large amounts of red meat and tobacco smoking may also increase the risk. Diagnosis, if enlarged lymph nodes are present, is usually by lymph node biopsy. Blood, urine, and bone marrow testing may also be useful in the diagnosis. Medical imaging may then be done to determine if and where the cancer has spread. Lymphoma most often spreads to the lungs, liver, and/or brain.
Treatment may involve one or more of the following: chemotherapy, radiation therapy, targeted therapy, and surgery. In some non-Hodgkin lymphomas, an increased amount of protein produced by the lymphoma cells causes the blood to become so thick that plasmapheresis is performed to remove the protein. Watchful waiting may be appropriate for certain types. The outcome depends on the subtype with some being curable and treatment prolonging survival in most. The five-year survival rate in the United States for all Hodgkin lymphoma subtypes is 85%, while that for non-Hodgkin lymphomas is 69%. Worldwide, lymphomas developed in 566,000 people in 2012 and caused 305,000 deaths. They make up 34% of all cancers, making them as a group the seventh-most common form. In children, they are the third-most common cancer. They occur more often in the developed world than the developing world., Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a category of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). Chemotherapy is one of the major categories of medical oncology (the medical discipline specifically devoted to pharmacotherapy for cancer)., Clarence Hubert Kay (born July 30, 1961 in Seneca, South Carolina) is a former professional American football player. A 6'2", 237-lb. tight end from the University of Georgia, Kay was selected by the Denver Broncos in the 7th round of the 1984 NFL Draft. Kay played in 9 NFL seasons from 19841992, all with the Broncos., Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Not all tumors are cancerous; benign tumors do not spread to other parts of the body. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss and a change in bowel movements. While these symptoms may indicate cancer, they may have other causes. Over 100 types of cancers affect humans.
Tobacco use is the cause of about 22% of cancer deaths. Another 10% is due to obesity, poor diet, lack of physical activity and drinking alcohol. Other factors include certain infections, exposure to ionizing radiation and environmental pollutants. In the developing world nearly 20% of cancers are due to infections such as hepatitis B, hepatitis C and human papillomavirus (HPV). These factors act, at least partly, by changing the genes of a cell. Typically many genetic changes are required before cancer develops. Approximately 510% of cancers are due to inherited genetic defects from a person's parents. Cancer can be detected by certain signs and symptoms or screening tests. It is then typically further investigated by medical imaging and confirmed by biopsy.
Many cancers can be prevented by not smoking, maintaining a healthy weight, not drinking too much alcohol, eating plenty of vegetables, fruits and whole grains, vaccination against certain infectious diseases, not eating too much processed and red meat, and avoiding too much sunlight exposure. Early detection through screening is useful for cervical and colorectal cancer. The benefits of screening in breast cancer are controversial. Cancer is often treated with some combination of radiation therapy, surgery, chemotherapy, and targeted therapy. Pain and symptom management are an important part of care. Palliative care is particularly important in people with advanced disease. The chance of survival depends on the type of cancer and extent of disease at the start of treatment. In children under 15 at diagnosis the five-year survival rate in the developed world is on average 80%. For cancer in the United States the average five-year survival rate is 66%.
In 2012 about 14.1 million new cases of cancer occurred globally (not including skin cancer other than melanoma). It caused about 8.2 million deaths or 14.6% of human deaths. The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer and stomach cancer. In females, the most common types are breast cancer, colorectal cancer, lung cancer and cervical cancer. If skin cancer other than melanoma were included in total new cancers each year it would account for around 40% of cases. In children, acute lymphoblastic leukaemia and brain tumors are most common except in Africa where non-Hodgkin lymphoma occurs more often. In 2012, about 165,000 children under 15 years of age were diagnosed with cancer. The risk of cancer increases significantly with age and many cancers occur more commonly in developed countries. Rates are increasing as more people live to an old age and as lifestyle changes occur in the developing world. The financial costs of cancer were estimated at $1.16 trillion US dollars per year as of 2010.
Definitions.
Cancers are a large family of diseases that involve abnormal cell growth with the potential to invade or spread to other parts of the body. They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often form a mass or lump, but may be distributed diffusely., A symptom (from Greek , "accident, misfortune, that which befalls", from , "I befall", from - "together, with" and , "I fall") is a departure from normal function or feeling which is noticed by a patient, reflecting the presence of an unusual state, or of a disease. A symptom is subjective, observed by the patient, and cannot be measured directly, whereas a sign is objectively observable by others. For example, paresthesia is a symptom (only the person experiencing it can directly observe their own tingling feeling), whereas erythema is a sign (anyone can confirm that the skin is redder than usual). Symptoms and signs are often nonspecific, but often combinations of them are at least suggestive of certain diagnoses, helping to narrow down what may be wrong. In other cases they are specific even to the point of being pathognomonic., Vaccination is the administration of antigenic material (a vaccine) to stimulate an individual's immune system to develop adaptive immunity to a pathogen. Vaccines can prevent or ameliorate morbidity from infection. When a sufficiently large percentage of a population has been vaccinated, this results in herd immunity. The effectiveness of vaccination has been widely studied and verified; for example, the influenza vaccine, the HPV vaccine, and the chicken pox vaccine. Vaccination is the most effective method of preventing infectious diseases; widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the restriction of diseases such as polio, measles, and tetanus from much of the world. The World Health Organization (WHO) reports that licensed vaccines are currently available to prevent or contribute to the prevention and control of twenty-five preventable infections., Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes. Melanomas typically occur in the skin but may rarely occur in the mouth, intestines, or eye. In women they most commonly occur on the legs, while in men they are most common on the back. Sometimes they develop from a mole with concerning changes including an increase in size, irregular edges, change in color, itchiness, or skin breakdown.
The primary cause of melanoma is ultraviolet light (UV) exposure in those with low levels of skin pigment. The UV light may be from either the sun or from other sources, such as tanning devices. About 25% develop from moles. Those with many moles, a history of affected family members, and who have poor immune function are at greater risk. A number of rare genetic defects such as xeroderma pigmentosum also increase risk. Diagnosis is by biopsy of any concerning skin lesion.
Using sunscreen and avoiding UV light may prevent melanoma. Treatment is typically removal by surgery. In those with slightly larger cancers, nearby lymph nodes may be tested for spread. Most people are cured if spread has not occurred. For those in whom melanoma has spread, immunotherapy, biologic therapy, radiation therapy, or chemotherapy may improve survival. With treatment the five-year survival rates in the United States is 98% among those with localized disease and 17% among those in whom spread has occurred. The likelihood that it will come back or spread depends how thick the melanoma is, how fast the cells are dividing, and whether or not the overlying skin has broken down.
Melanoma is the most dangerous type of skin cancer. Globally, in 2012, it occurred in 232,000 people and resulted in 55,000 deaths. Australia and New Zealand have the highest rates of melanoma in the world. There are also high rates in Northern Europe and North America, while it is less common in Asia, Africa, and Latin America. Melanoma is more common in men than women. Melanoma has become more common since the 1960s in areas that are mostly Caucasian., Super Bowl XXIV was an American football game between the National Football Conference (NFC) champion San Francisco 49ers and the American Football Conference (AFC) champion Denver Broncos to decide the National Football League (NFL) champion for the 1989 season. Played on January 28, 1990, at the Louisiana Superdome in New Orleans, Louisiana, the 49ers defeated the Broncos by the score of 5510, winning their second consecutive Super Bowl, and tying the Pittsburgh Steelers with four Super Bowl victories. San Francisco also became the first team to win back-to-back Super Bowls with two different head coaches; rookie head coach George Seifert took over after Bill Walsh retired after the previous season's Super Bowl., Infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to these organisms and the toxins they produce. Infectious disease, also known as transmissible disease or communicable disease, is illness resulting from an infection.
Infections are caused by infectious agents including viruses, viroids, prions, bacteria, nematodes such as parasitic roundworms and pinworms, arthropods such as ticks, mites, fleas, and lice, fungi such as ringworm, and other macroparasites such as tapeworms and other helminths., The New York Jets are a professional American football team located in the New York metropolitan area. The Jets compete in the National Football League (NFL) as a member club of the league's American Football Conference (AFC) East division. The team is headquartered in Florham Park, New Jersey. In a unique arrangement for the league, the Jets share MetLife Stadium in East Rutherford, New Jersey with the New York Giants. The franchise is legally and corporately registered as New York Jets, LLC., Skin cancers are cancers that arise from the skin. They are due to the development of abnormal cells that have the ability to invade or spread to other parts of the body. There are three main types of skin cancers: basal-cell skin cancer (BCC), squamous-cell skin cancer (SCC) and melanoma. The first two together along with a number of less common skin cancers are known as nonmelanoma skin cancer (NMSC). Basal-cell cancer grows slowly and can damage the tissue around it but is unlikely to spread to distant areas or result in death. It often appears as a painless raised area of skin, that may be shiny with small blood vessel running over it or may present as a raised area with an ulcer. Squamous-cell cancer is more likely to spread. It usually presents as a hard lump with a scaly top but may also form an ulcer. Melanomas are the most aggressive. Signs include a mole that has changed in size, shape, color, has irregular edges, has more than one color, is itchy or bleeds.
Greater than 90% of cases are caused by exposure to ultraviolet radiation from the Sun. This exposure increases the risk of all three main types of skin cancer. Exposure has increased partly due to a thinner ozone layer. Tanning beds are becoming another common source of ultraviolet radiation. For melanomas and basal-cell cancers exposure during childhood is particularly harmful. For squamous-cell cancers total exposure, irrespective of when it occurs, is more important. Between 20% and 30% of melanomas develop from moles. People with light skin are at higher risk as are those with poor immune function such as from medications or HIV/AIDS. Diagnosis is by biopsy.
Decreasing exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing melanoma and squamous-cell cancer. It is not clear if sunscreen affects the risk of basal-cell cancer. Nonmelanoma skin cancer is usually curable. Treatment is generally by surgical removal but may less commonly involve radiation therapy or topical medications such as fluorouracil. Treatment of melanoma may involve some combination of surgery, chemotherapy, radiation therapy, and targeted therapy. In those people whose disease has spread to other areas of their bodies, palliative care may be used to improve quality of life. Melanoma has one of the higher survival rates among cancers, with over 86% of people in the UK and more than 90% in the United States surviving more than 5 years.
Skin cancer is the most common form of cancer, globally accounting for at least 40% of cases. It is especially common among people with light skin. The most common type is nonmelanoma skin cancer, which occurs in at least 2-3 million people per year. This is a rough estimate, however, as good statistics are not kept. Of nonmelanoma skin cancers, about 80% are basal-cell cancers and 20% squamous-cell cancers. Basal-cell and squamous-cell cancers rarely result in death. In the United States they were the cause of less than 0.1% of all cancer deaths. Globally in 2012 melanoma occurred in 232,000 people, and resulted in 55,000 deaths. Australia and New Zealand have the highest rates of melanoma in the world. The three main types of skin cancer have become more common in the last 20 to 40 years, especially in those areas which are mostly Caucasian., A single-elimination tournamentalso called an Olympic system tournament, a knockout (or, knock-out), single penetration, or sudden death tournamentis a type of elimination tournament where the loser of each bracket is immediately eliminated from winning the championship or first prize in the event., Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung. If left untreated, this growth can spread beyond the lung by the process of metastasis into nearby tissue or other parts of the body. Most cancers that start in the lung, known as primary lung cancers, are carcinomas. The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC). The most common symptoms are coughing (including coughing up blood), weight loss, shortness of breath, and chest pains.
The vast majority (85%) of cases of lung cancer are due to long-term tobacco smoking. About 1015% of cases occur in people who have never smoked. These cases are often caused by a combination of genetic factors and exposure to radon gas, asbestos, second-hand smoke, or other forms of air pollution. Lung cancer may be seen on chest radiographs and computed tomography (CT) scans. The diagnosis is confirmed by biopsy which is usually performed by bronchoscopy or CT-guidance.
Prevention is by avoiding risk factors including smoking and air pollution. Treatment and long-term outcomes depend on the type of cancer, the stage (degree of spread), and the person's overall health. Most cases are not curable. Common treatments include surgery, chemotherapy, and radiotherapy. NSCLC is sometimes treated with surgery, whereas SCLC usually responds better to chemotherapy and radiotherapy.
Worldwide in 2012, lung cancer occurred in 1.8 million people and resulted in 1.6 million deaths. This makes it the most common cause of cancer-related death in men and second most common in women after breast cancer. The most common age at diagnosis is 70 years. Overall, 17.4% of people in the United States diagnosed with lung cancer survive five years after the diagnosis, while outcomes on average are worse in the developing world.
Signs and symptoms.
Signs and symptoms which may suggest lung cancer include:, Patrick Joseph Kelly II ( October 29 , 1965 - March 28 , 2003 ) was a National Football League tight end who played for the Denver Broncos ( 1988 -- 1989 ) and the New York Jets ( 1990 -- 1991 ) . He played in 44 games over 4 seasons , starting only the 1988 AFC Championship due to an injury to starter Clarence Kay . Kelly also played in Super Bowl XXIV . He died of cancer on March 28 , 2003 ., Patrick Dennis Bowlen (born February 18, 1944) is the majority owner of the Denver Broncos of the National Football League (NFL). The Bowlen Family, including his two brothers John Bowlen and Bill Bowlen, and sister Marybeth Bowlen, purchased the team from Edgar Kaiser in 1984. He served as the Broncos CEO from his purchase of the club in 1984 until July 2014, when he stepped down as Broncos' CEO due to the onset and progression of Alzheimer's disease., Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, or a red scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin.
Risk factors for developing breast cancer include being female, obesity, lack of physical exercise, drinking alcohol, hormone replacement therapy during menopause, ionizing radiation, early age at first menstruation, having children late or not at all, older age, and family history. About 510% of cases are due to genes inherited from a person's parents, including BRCA1 and BRCA2 among others. Breast cancer most commonly develops in cells from the lining of milk ducts and the lobules that supply the ducts with milk. Cancers developing from the ducts are known as ductal carcinomas, while those developing from lobules are known as lobular carcinomas. In addition, there are more than 18 other sub-types of breast cancer. Some cancers, such as ductal carcinoma in situ, develop from pre-invasive lesions. The diagnosis of breast cancer is confirmed by taking a biopsy of the concerning lump. Once the diagnosis is made, further tests are done to determine if the cancer has spread beyond the breast and which treatments it may respond to.
The balance of benefits versus harms of breast cancer screening is controversial. A 2013 Cochrane review stated that it is unclear if mammographic screening does more good or harm. A 2009 review for the US Preventive Services Task Force found evidence of benefit in those 40 to 70 years of age, and the organization recommends screening every two years in women 50 to 74 years old. The medications tamoxifen or raloxifene may be used in an effort to prevent breast cancer in those who are at high risk of developing it. Surgical removal of both breasts is another preventative measure in some high risk women. In those who have been diagnosed with cancer, a number of treatments may be used, including surgery, radiation therapy, chemotherapy, hormonal therapy and targeted therapy. Types of surgery vary from breast-conserving surgery to mastectomy. Breast reconstruction may take place at the time of surgery or at a later date. In those in whom the cancer has spread to other parts of the body, treatments are mostly aimed at improving quality of life and comfort.
Outcomes for breast cancer vary depending on the cancer type, extent of disease, and person's age. Survival rates in the developed world are high, with between 80% and 90% of those in England and the United States alive for at least 5 years. In developing countries survival rates are poorer. Worldwide, breast cancer is the leading type of cancer in women, accounting for 25% of all cases. In 2012 it resulted in 1.68 million cases and 522,000 deaths. It is more common in developed countries and is more than 100 times more common in women than in men., Prostate cancer, also known as carcinoma of the prostate, is the development of cancer in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, some grow relatively quickly. The cancer cells may spread from the prostate to other parts of the body, particularly the bones and lymph nodes. It may initially cause no symptoms. In later stages it can lead to difficulty urinating, blood in the urine, or pain in the pelvis, back or when urinating. A disease known as benign prostatic hyperplasia may produce similar symptoms. Other late symptoms may include feeling tired due to low levels of red blood cells.
Factors that increase the risk of prostate cancer include: older age, a family history of the disease, and race. About 99% of cases occur in those over the age of 50. Having a first-degree relative with the disease increases the risk two to threefold. In the United States it is more common in the African American population than the white American population. Other factors that may be involved include a diet high in processed meat, red meat, or milk products or low in certain vegetables. An association with gonorrhea has been found, but a reason for this relationship has not been identified. Prostate cancer is diagnosed by biopsy. Medical imaging may then be done to determine if the cancer has spread to other parts of the body.
Prostate cancer screening is controversial. Prostate-specific antigen (PSA) testing increases cancer detection but does not decrease mortality. The United States Preventive Services Task Force recommends against screening using the PSA test, due to the risk of overdiagnosis and overtreatment, as most cancer diagnosed would remain asymptomatic. The USPSTF concludes that the potential benefits of testing do not outweigh the expected harms. While 5-reductase inhibitors appear to decrease low-grade cancer risk they do not affect high-grade cancer risk and thus are not recommended for prevention. Supplementation with vitamins or minerals does not appear to affect the risk.
Many cases can be safely followed with active surveillance or watchful waiting. Other treatments may include a combination of surgery, radiation therapy, hormone therapy or chemotherapy. When it only occurs inside the prostate it may be curable. In those in whom the disease has spread to the bones, pain medications, bisphosphonates and targeted therapy, among others, may be useful. Outcomes depend on a person's age and other health problems as well as how aggressive and extensive the cancer is. Most people with prostate cancer do not end up dying from the disease. The 5-year survival rate in the United States is 99%. Globally it is the second most common type of cancer and the fifth leading cause of cancer-related death in men. In 2012 it occurred in 1.1 million men and caused 307,000 deaths. It was the most common cancer in males in 84 countries, occurring more commonly in the developed world. Rates have been increasing in the developing world. Detection increased significantly in the 1980s and 1990s in many areas due to increased PSA testing. Studies of males who died from unrelated causes have found prostate cancer in 30% to 70% of those over age 60.
Signs and symptoms.
Early prostate cancer usually has no clear symptoms. Sometimes, however, prostate cancer does cause symptoms, often similar to those of diseases such as benign prostatic hyperplasia. These include frequent urination, nocturia (increased urination at night), difficulty starting and maintaining a steady stream of urine, hematuria (blood in the urine), and dysuria (painful urination). A study based on the 1998 Patient Care Evaluation in the US found that about a third of patients diagnosed with prostate cancer had one or more such symptoms, while two-thirds had no symptoms., Subject: pat kelly , Relation: cause_of_death, Options: (A) brain tumor (B) breast cancer (C) cancer (D) carcinoma (E) cervical cancer (F) club (G) consumption (H) disease (I) fall (J) fever (K) heart disease (L) hepatitis (M) hepatitis c (N) illness (O) infection (P) influenza (Q) injury (R) jaundice (S) leukemia (T) liver cancer (U) lymphoma (V) measles (W) melanoma (X) multiple myeloma (Y) skin cancer (Z) smallpox ([) tournament (\) tumor
Example Output:
brain tumor