Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Example Input: Context: To investigate whether gender is an independent factor associated with disease expression in early rheumatoid arthritis (RA) patients. 438 patients with early RA (disease duration less than one year) were studied. They all were patients with early RA who presented at the Rheumatology Clinic of the University Hospital of Ioannina during the period 1991-2000. All patients fulfilled the American College of Rheumatology criteria for RA. The demographic, clinical, laboratory, radiological and therapeutic characteristics of the disease at diagnosis, and at the last follow-up were analyzed according to gender. We studied 312 women and 126 men with early RA. The female to male ratio was 2.5:1 and the mean age at diagnosis was 49.4 +/- 14.9 years for women and 55.3 +/-15.6 years for men (P < 0.0003). Women had a longer duration of follow-up (P < 0.0003). There were no differences between genders in the general symptoms or the simmetricity of joint involvement at at disease onset. However at disease onset women had a higher erythrocyte sedimentation rate (ESR) (> 30 mm/1st hour), although there were no significant differences between the two groups concerninig the rest of the clinical, laboratory and radiological findings. At the last follow-up women still had a higher ESR (>30 min/1st hour), but no significant differences were found between the two groups concerning the rest of the parameters investigated independently of the follow-up duration. Finally, women and men showed the same degree of radiological changes and functional ability and were treated similarly except for the more frequent use of hydroxychloroquine in women. It seems that gender does not signficantly influence the expression of RA. 
 Question: Is Rheumatoid Arthritis more common in men or women?
Example Output: women

Example Input: Context: Week 10 featured the top-ranked defenses (by yardage against) in each conference, as the Lions hosted the Dolphins. Detroit got off to a quick start. Matt Prater kicked a 26-yard field goal on the opening drive of the game. Later in the first quarter, Calvin Johnson, playing in his first game since Week 5, caught a 49-yard TD pass from Matthew Stafford for a 10-0 lead. Miami managed a 23-yard Caleb Sturgis field goal before halftime, making the score 10-3. The Dolphins took the lead in the third, starting with a 50-yard Stugis field goal. Next, Earl Mitchell blocked Prater's 42-yard field goal attempt, and Dion Jordan returned the ball to the Lions 3-yard line. On the next play, Ryan Tannehill connected with Mike Wallace for the touchdown, putting Miami ahead, 13-10. Prater made good on a 50-yard field goal early in the fourth quarter to knot the score at 13-13, but Sturgis' 20-yarder put Miami back on top by 3. As in the previous two games, the Lions had to rally on their final drive to win the game. Starting at their own 26 with 3:13 left in the game, the drive culminated with Stafford's 11-yard touchdown pass to Theo Riddick, putting the Lions ahead for good, 20-16. This was the third straight game in which the Lions trailed at the two-minute warning, then went ahead on their final drive. It was the second time in a month that Miami had lost a game in the final seconds, following a Week 7 loss to Green Bay in which the final touchdown was scored with 3 seconds remaining. According to STATS Inc., this is the first time Detroit has started a season 7-2 since 1993. 
 Question: Which player threw the last touchdown pass of the game?
Example Output: matthew stafford

Example Input: Context: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a small vessel disease of the brain caused by mutations in the NOTCH3 gene. CADASIL progresses, in some cases, to subcortical dementia with a particular cognitive impairment. Different diseases in the dementia spectrum share a central cholinergic and sensorimotor plasticity alteration. We aimed to study different intracortical circuits and sensorimotor plasticity in CADASIL patients using transcranial magnetic stimulation protocols, and to determine whether these characteristics correlated with the results of clinical neuropsychological evaluation. Ten CADASIL patients and 10 healthy subjects were included in the study. All subjects underwent a transcranial magnetic stimulation study examining different intracortical circuits. Sensorimotor plasticity was also assessed using a paired associative stimulation and extensive neuropsychological tests. CADASIL patients showed a lack of intracortical facilitation, short latency afferent inhibition and sensorimotor plasticity when compared with control subjects. CADASIL patients also showed an altered neuropsychological profile. Correlation between sensorimotor plasticity and neuropsychological alterations was observed in CADASIL patients. These results suggest that acetylcholine and glutamate could be involved in the dementia process in CADASIL and that abnormal sensorimotor plasticity correlates with the neuropsychological profile in CADASIL patients. 
 Question: Which gene is involved in CADASIL?
Example Output:
notch3 gene