Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Q: Context: Varespladib methyl is an oral secretory phospholipase A2 inhibitor that is being developed by Anthera Pharmaceuticals Inc for the potential treatment of coronary artery disease, acute coronary syndrome and inflammation. Varespladib methyl is a prodrug that is rapidly metabolized to varespladib, and both compounds are able to potently inhibit the enzymes of the human secretory phospholipase groups IIa, V and X, which play a pivotal role in atherosclerotic disease and inflammation. Phase II clinical trials of varespladib methyl in patients with coronary artery disease, rheumatoid arthritis, asthma and ulcerative colitis revealed that the drug was well tolerated. Varespladib methyl did not demonstrate a good efficacy profile in patients with rheumatoid arthritis, asthma and ulcerative colitis, whereas in patients with coronary artery disease, varespladib methyl consistently reduced LDL-cholesterol levels (elevated LDL-cholesterol levels are a marker of increased cardiovascular risk). At the time of publication, phase II trials were ongoing in patients with acute coronary syndrome and in patients undergoing elective percutaneous coronary intervention, and a phase III trial in patients with acute coronary syndrome was planned. Varespladib methyl could represent a novel therapy for the treatment of cardiovascular disease, although the efficacy, safety profile and advantages of this drug compared with existing therapeutic options would need to be established in upcoming phase III trials. 
 Question: Which enzyme is inhibited by Varespladib?

A: secretory phospholipase a2
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Q: Context: From the outside, the skin looks plain and simple, as you can see in Figure 16.5. But at a cellular level, theres nothing plain or simple about it. A single square inch of skin contains about 20 blood vessels, hundreds of sweat glands, and more than a thousand nerve endings. It also contains tens of thousands of pigment-producing cells. Clearly, there is much more to skin than meets the eye! For a dramatic introduction to the skin, watch this video: MEDIA Click image to the left or use the URL below. URL: The skin is only about 2 mm thick, or about as thick as the cover of a book. Although it is very thin, it consists of two distinct layers, called the epidermis and the dermis. You can see both layers and some of their structures in Figure 16.6. Refer to the figure as you read about the epidermis and dermis below. The epidermis is the outer layer of skin. It consists almost entirely of epithelial cells. There are no blood vessels, nerve endings, or glands in this skin layer. Nonetheless, this layer of skin is very active. It is constantly being renewed. How does this happen? 1. The cells at the bottom of the epidermis are always dividing by mitosis to form new cells. 2. The new cells gradually move up through the epidermis toward the surface of the body. As they move, they produce the tough, fibrous protein called keratin. 3. By the time the cells reach the surface, they have filled with keratin and died. On the surface, the dead cells form a protective, waterproof layer. 4. Dead cells are gradually shed from the surface of the epidermis. As they are shed, they are replaced by other dead cells that move up from below. The epidermis also contains cells called melanocytes. You can see a melanocyte in Figure 16.7. Melanocytes produce melanin. Melanin is a brown pigment that gives skin much of its color. Everyones skin has about the same number of melanocytes per square inch. However, the melanocytes of people with darker skin produce more melanin. The amount of melanin that is produced depends partly on your genes and partly on how much ultraviolet light strikes your skin. The more light you get, the more melanin your melanocytes produce. This explains why skin tans when its exposed to sunlight. The dermis is the inner layer of skin. It is made of tough connective tissue. The dermis is attached to the epidermis by fibers made of the protein collagen. The dermis is where most skin structures are located. Look again at Figure pain, pressure, and temperature. If you cut your skin and it bleeds, the cut has penetrated the dermis and damaged a blood vessel. The cut probably hurts as well because of the nerve endings in this skin layer. The dermis also contains hair follicles and two types of glands. You can see some of these structures in Figure 16.8. Hair follicles are structures where hairs originate. Each hair grows out of a follicle, passes up through the epidermis, and extends above the skin surface. Sebaceous glands are commonly called oil glands. They produce an oily substance called sebum. Sebum is secreted into hair follicles. Then it makes its way along the hair shaft to the surface of the skin. Sebum waterproofs the hair and skin and helps prevent them from drying out. Sweat glands produce the salty fluid known as sweat. Sweat contains excess water, salts, and other waste products. Each sweat gland has a duct that passes through the epidermis. Sweat travels from the gland through the duct and out through a pore on the surface of the skin. You couldnt survive without your skin. It has many important functions. In several ways, it helps maintain homeostasis. The main function of the skin is controlling what enters and leaves the body. It prevents the loss of too much water from the body. It also prevents bacteria and other microorganisms from entering the body. Melanin in the epidermis absorbs ultraviolet light. This prevents the light from reaching and damaging the dermis. The skin helps maintain a constant body temperature. It 
 Question: __major organ of the integumentary system

A: skin
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Q: Context: Protists are placed in the Protist Kingdom. This kingdom is one of four kingdoms in the Eukarya domain. The other three Eukarya kingdoms are the Fungi, Plant, and Animal Kingdoms. The Protist Kingdom is hard to define. It includes many different types of organisms. You can see some examples of protists in Figure 9.1. The Protist Kingdom includes all eukaryotes that dont fit into one of the other three eukaryote kingdoms. For that reason, its sometimes called the trash can kingdom. The number of species in the Protist Kingdom is unknown. It could range from as few as 60,000 to as many as 200,000 species. For a beautiful introduction to the amazing world of protists, watch this video: MEDIA Click image to the left or use the URL below. URL: Scientists think that protists are the oldest eukaryotes. If so, they must have evolved from prokaryotes. How did this happen? How did cells without organelles acquire them? What was the origin of mitochondria, chloroplasts, and other organelles? The most likely way organelles evolved is shown in Figure 9.2. First, smaller prokaryotic cells invaded, or were engulfed by, larger prokaryotic cells. The smaller cells benefited by getting nutrients and a safe place to live. The larger cells benefited by getting some of the organic molecules or energy released by the smaller cells. Eventually, the smaller cells evolved into organelles in the larger cells. After that, neither could live without the other. Despite the diversity of protists, they do share some traits. The cells of all protists have a nucleus. They also have other membrane-bound organelles. For example, all of them have mitochondria, and some of them have chloroplasts. Most protists consist of a single cell. Some are multicellular but they lack specialized cells. Most protists live in wet places. They are found in oceans, lakes, swamps, or damp soils. Many protists can move. Most protists also have a complex life cycle. The life cycle of an organism is the cycle of phases it goes through until it returns to the starting phase. The protist life cycle includes both sexual and asexual reproduction. Why reproduce both ways? Each way has benefits. Asexual reproduction is fast. It allows rapid population growth when conditions are stable. Sexual reproduction increases genetic variation. This helps ensure that some organisms will survive if conditions change. Protists are classified based on traits they share with other eukaryotes. There are animal-like, plant-like, and fungus- like protists. The three groups differ mainly in how they get carbon and energy. Animal-like protists are called protozoa (protozoan, singular). Most protozoa consist of a single cell. Protozoa are probably ancestors of animals. Protozoa are like animals in two ways: 1. Protozoa are heterotrophs. Heterotrophs get food by eating other organisms. Some protozoa prey on bacteria. Some are parasites of animals. Others graze on algae. Still others are decomposers that break down dead organic matter. 2. Almost all protozoa can move. They have special appendages for this purpose. You can see different types in Figure 9.3. Cilia (cilium, singular) are short, hair-like projections. Pseudopods are temporary extensions of the cytoplasm. Flagella are long, whip-like structures. Flagella are also found in most prokaryotes. Plant-like protists are commonly called algae (alga, singular). Some algae consist of single cells. They are called diatoms. Other algae are multicellular. An example is seaweed. Seaweed called kelp can grow as large as trees. You can see both a diatom and kelp in Figure 9.4. Algae are probably ancestors of plants. Algae are like plants mainly because they contain chloroplasts. This allows them to make food by photosynthesis. Algae are important producers in water-based ecosystems such as the ocean. On the other hand, algae lack other plant structures. For example, they dont have roots, stems, or leaves. Also unlike plants, some algae can move. They may move with pseudopods or flagella. Fungus-like protists include slime molds and water molds, both shown in Figure 9.5. They exist 
 Question: What is a benefit of sexual reproduction over asexual reproduction?

A:
sexual reproduction increases genetic variation
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