Compose a new way to ask the same question. The new question must be asking the exact same thing as the original question does. Without any other information, you should be able to tell that the original question and the new question are the same. Preserve bracketed phrases in your new question. You can change the rest of the question provided the above requirements are satisfied. The new question must have a natural, fluent formulation, as if it were composed by a native English speaker. You will be given three pieces of information to help you create better questions. Those are: "Answer": the answer to the question, e.g., "Honolulu". "Answer Type": the type of the answer, e.g., "Location". "Auxiliary Information" is a detailed description of some concepts mentioned in the question, if any.

Q: original question: Which chemical classification is the higher one of the classification that is the higher classification of [Enzyme]?
answer: organic compound
answer type: Chemical Classification.
auxiliary information: Enzymes /Àà…õnza…™mz/ are macromolecular biological catalysts. Enzymes accelerate, or catalyze, chemical reactions. The molecules at the beginning of the process are called substrates and the enzyme converts these into different molecules, called products. Almost all metabolic processes in the cell need enzymes in order to occur at rates fast enough to sustain life. The set of enzymes made in a cell determines which metabolic pathways occur in that cell. The study of enzymes is called enzymology. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Most enzymes are proteins, although a few are catalytic RNA molecules. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the rate of a reaction by lowering its activation energy. Some enzymes can make their conversion of substrate to product occur many millions of times faster. An extreme example is orotidine 5'-phosphate decarboxylase, which allows a reaction that would otherwise take millions of years to occur in milliseconds.

A: What is the chemical classification that is the higher one of the classification that is higher than the [Enzyme] classification.
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Q: original question: Which filming location is featured in a concert film in [London]? 
answer: oakland, san francisco
answer type: Filming location.
auxiliary information: London /Ààl ånd…ôn/ is the capital and most populous city of England and the United Kingdom. Standing on the River Thames, London has been a major settlement for two millennia, its history going back to its founding by the Romans, who named it Londinium. London's ancient core, the City of London, largely retains its 1.12-square-mile medieval boundaries and in 2011 had a resident population of 7,375, making it the smallest city in England. Since at least the 19th century, the term London has also referred to the metropolis developed around this core. The bulk of this conurbation forms Greater London, a region of England governed by the Mayor of London and the London Assembly. The conurbation also covers two English counties: the City of London and the county of Greater London. London is a leading global city, with strengths in the arts, commerce, education, entertainment, fashion, finance, healthcare, media, professional services, research and development, tourism, and transport all contributing to its prominence. It is one of the world's leading financial centres and has the fifth-or sixth-largest metropolitan area GDP in the world depending on measurement.

A: In a [London] concert film, which filming location is featured?
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Q: original question: Which comic book penciler has penciled the comic story of [Sin City]?
answer: frank miller
answer type: Comic Book Penciler.
auxiliary information: Sin City is the title for a series of neo-noir comics by Frank Miller. The first story originally appeared in "Dark Horse Presents Fifth Anniversary Special", and continued in Dark Horse Presents #51‚Äì62 from May 1991 to June 1992, under the title of Sin City, serialized in thirteen parts. Several other stories of variable lengths have followed. The intertwining stories, with frequently recurring characters, take place in Basin City. A movie adaptation of Sin City, co-directed by Robert Rodriguez and Frank Miller, was released on April 1, 2005. A sequel, Sin City: A Dame To Kill For, was released on August 22, 2014.

A:
Who penciled [Sin City]?
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