This task is about reading the given passage and construct a question about the information present in the passage. Construct a question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) its answer is a continuous text span from the paragraph. Avoid creating questions that (i) can be answered correctly without actually understanding the paragraph and (ii) uses same words or phrases given in the passage.

Serotonin is a neuromodulator involved in regulation of mood and behavior. Development in the limbic system plays an important role in determining rewards and punishments and processing emotional experience and social information. Changes in the levels of the neurotransmitters dopamine and serotonin in the limbic system make adolescents more emotional and more responsive to rewards and stress. The corresponding increase in emotional variability also can increase adolescents' vulnerability. The effect of serotonin is not limited to the limbic system: Several serotonin receptors have their gene expression change dramatically during adolescence, particularly in the human frontal and prefrontal cortex .
Which neuromodulator is involved in regulation of mood and behavior?

Another issue has been the use of a hypopodium as a standing platform to support the feet, given that the hands may not have been able to support the weight. In the 17th century Rasmus Bartholin considered a number of analytical scenarios of that topic. In the 20th century, forensic pathologist Frederick Zugibe performed a number of crucifixion experiments by using ropes to hang human subjects at various angles and hand positions. His experiments support an angled suspension, and a two-beamed cross, and perhaps some form of foot support, given that in an Aufbinden form of suspension from a straight stake (as used by the Nazis in the Dachau concentration camp during World War II), death comes rather quickly.
What was said to be used as a platform for crucifixion?

By the early 18th century, the Maratha Kingdom had transformed itself into the Maratha Empire under the rule of the Peshwas (prime ministers). In 1737, the Marathas defeated a Mughal army in their capital, Delhi itself in Battle of Delhi (1737). The Marathas continued their military campaigns against Mughals, Nizam, Nawab of Bengal and Durrani Empire to further extend their boundaries. Gordon explained how the Maratha systematically took control over new regions. They would start with annual raids, followed by collecting ransom from villages and towns while the declining Mughal Empire retained nominal control and finally taking over the region. He explained it with the example of Malwa region. Marathas built an efficient system of public administration known for its attention to detail. It succeeded in raising revenue in districts that recovered from years of raids, up to levels previously enjoyed by the Mughals. For example, the cornerstone of the Maratha rule in Malwa rested on the 60 or so local tax collectors who advanced the Maratha ruler Peshwa a portion of their district revenues at interest. By 1760, the domain of the Marathas stretched across practically the entire subcontinent. The north-western expansion of the Marathas was stopped after the Third Battle of Panipat (1761). However, the Maratha authority in the north was re-established within a decade under Peshwa Madhavrao I. The defeat of Marathas by British in third Anglo-Maratha Wars brought end to the empire by 1820. The last peshwa, Baji Rao II, was defeated by the British in the Third Anglo-Maratha War. With the defeat of the Marathas, no native power represented any significant threat for the British afterwards.

By when had the Maratha kingdom become an empire?