Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: Riociguat (Adempas(®)), a soluble guanylate cyclase stimulator, is a new, first-in-class drug approved for the treatment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) [inoperable or persistent/recurrent following surgery] or pulmonary arterial hypertension (PAH). It has been designated an orphan medicine by the European Medicines Agency and the US FDA. This article reviews the available pharmacological properties of oral riociguat and its clinical efficacy and tolerability in adults with CTEPH or PAH. Riociguat is effective and well tolerated in patients with inoperable CTEPH or persistent/recurrent CTEPH following pulmonary endarterectomy, and in patients with PAH. It has a positive result on exercise capacity and pulmonary haemodynamics, and improves WHO functional class. Most adverse events can be attributed to the vasodilatory mechanism of riociguat; however, there is a potential for serious bleeding and fetal harm, and riociguat use is contraindicated in pregnant patients. Pulmonary endarterectomy remains the first treatment of choice for CTEPH, as it is potentially curative. Head-to-head trials comparing riociguat with the approved phosphodiesterase type 5 inhibitors in patients with PAH would be of value for the placement of riociguat in the management of this disease. Riociguat is a promising addition to the treatment options for patients with CTEPH or PAH.

Output: What is generic name of drug Adempas?


Input: Consider Input: You're in your office when you learn there's someone with a gun wandering outside. You can hear gunshots and screams. What do you do? That's the challenge for users of a new virtual reality program called SurviVR, designed to train employees how to deal with an active shooter situation in the workplace. The program works with HTC Vive, the virtual reality headset released earlier this year. An active shooter situation is when an armed person or people actively shoot in a small, populated area with the intention to kill. There were 20 such situations in the United States last year and 20 the year before, according to FBI statistics, resulting in a total of 231 deaths. This year saw the deadliest active shooter situation in US history , with 49 people killed in a nightclub in Orlando. In the training situation, users have four choices. They can lock themselves in the office. They can hide, perhaps in the office closet. They can run for an exit. Or they can use something in the office--a computer or a cup a pair of scissors-as a weapon to fight the shooter. This is an improvement on standard active shooter training. Gallo says, which typically teachers people to lock themselves in place and hide. The "lock down" method is often ineffective, he says, and has resulted in many deaths in recent years. In the training's basic level, no one gets killed. But as the trainings become more advanced, players who make a wrong choice be shot. There's no blood; the screen simply turns black slowly. If this sounds terrifying, that's the point, says Gallo. There are plenty of training programs to teach employees how to deal with workplace violence, sometimes involving role play with toy guns. But these trainings are basically games. Gallo says, with employees relaxed and even enjoying themselves. To teach people what they really need to know for an active shooter situation, they need to be scared. "SurviVR will take the fear and turn it into confidence." Gallo says.

Output: What does Gallo think of the training programs involving role play with toy guns?


Input: Consider Input: Lindsay (Ashley C. Williams) and Jenny (Ashlynn Yennie), two American tourists in Germany, are drugged and involuntarily detained by crazed surgeon Dr. Josef Heiter (Dieter Laser) when they seek help at his house after they get a flat tire. The women awake in a makeshift medical ward. They witness Heiter kill a kidnapped truck driver after Heiter informs him he is "not a match". Heiter secures a new male captive, Japanese tourist Katsuro (Akihiro Kitamura). The doctor explains that he is a world-renowned expert at separating Siamese twins, but dreams of making new creatures by sewing people together. He describes in detail how he will surgically connect his three victims mouth-to-anus, so that they share a single digestive system. After Lindsay tries to escape and fails, Heiter explains that he had previously experimented with creating what he called a "three-dog", also joined mouth-to-anus. However, the three-dog died shortly after surgery. Heiter tells Lindsay that one dog tried to escape and that dog became the middle, thus this caused the most pain to the dog and as punishment for her escape attempt, she will become the middle part of his centipede. Heiter performs the surgery, placing Katsuro at the front, Lindsay in the middle and Jenny at the rear. He removes the front teeth of both women and mutilates the buttocks of both Katsuro and Lindsay in order to provide easier access to the rectums, to which he hideously stitches and grafts their mouths. During his procedure, he severs the ligaments within his victims' knees to prevent leg extension, forcing his victims to crawl. He then connects his victims together in a straight line with their mouths surgically attached to the anus of the victim in front of them. Once the operation is complete, Heiter attempts to train his centipede as a pet, often belittling Katsuro with racist insults and beating him with a crop when he becomes rebellious. When Katsuro defecates, Lindsay is forced to swallow his excrement while the doctor watches in delight. However, he eventually becomes irritated after being kept awake by the constant screaming of Katsuro (who, as the front part of the centipede, has his mouth free and is still able to speak) and the realization that Jenny is dying from septicemia. When two detectives, Kranz (Andreas Leupold) and Voller (Peter Blankenstein), visit the house to investigate the disappearance of tourists, Heiter comes up with an idea to add them as replacements for Jenny in a new creation; a four-segment centipede. He offers the two detectives water spiked with sedatives in hopes of knocking the two unconscious. After being given the water, the detectives become suspicious and obtain a search warrant for his home. While the detectives leave Heiter's home, the victims attempt to escape. Katsuro attacks Heiter in the process. Their attempt to escape ultimately fails. Katsuro confesses to the doctor that he deserves his fate because he had treated his own family poorly, then commits suicide by slitting his throat with a glass shard. Upon returning to Heiter's home, the detectives forcefully conduct separate searches as an injured Heiter hides near his swimming pool. Kranz finds the ward along with Heiter's victims. Voller begins to feel ill from the earlier drugging, and Heiter stabs him with the scalpel pulled from his leg during Katsuro's attack. Upon finding Voller dead, Kranz is shot by Heiter with Voller's sidearm. Kranz responds by shooting Heiter in the head before dying. Back in the house, Jenny and Lindsay hold hands as Jenny dies. Lindsay sobs as she is left alone in the house, trapped between her deceased fellow captives. Her fate is left unknown. The film ends with the sounds of her sobbing while the camera pans to the roof of the house.


Output: what type of poisoning is Jenny dying from?