TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Does obesity independently influence gonadal function in very long-term adult male survivors of childhood cancer?
Answer: Obesity is associated with gonadal dysfunction in male CCS, independent of the irreversible effect of previous cancer treatment. Randomized controlled trials are required to evaluate whether weight normalization could improve gonadal function, especially in obese survivors with potential other mechanisms than lifestyle causing their obesity.

SOLUTION: yes

PROBLEM: Question: Is cYP3A5 genotype associated with a higher risk of acute rejection in tacrolimus-treated renal transplant recipients?
Answer: We conclude that patients expressing CYP3A5 need more tacrolimus to reach target concentrations and have a lower tacrolimus exposure shortly after transplantation. This delay in reaching target concentrations, however, did not result in an increased incidence of early BPAR and therefore, genotyping for CYP3A5 is unlikely to improve short-term transplantation outcome.

SOLUTION: no

PROBLEM: Question: Does iGF-I secretion by prostate carcinoma cells alter tumor-bone cell interactions in vitro or in vivo?
Answer: IGF-I is neither necessary nor sufficient for the osteoblastic response to PC metastases.

SOLUTION:
no