Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: Nuclear receptor co-repressor (N-CoR) plays important role in transcriptional control mediated by several tumor suppressor proteins. Recently, we reported a role of misfolded-conformation dependent loss (MCDL) of N-CoR in the activation of oncogenic survival pathway in acute promyelocytic leukemia (APL). Since N-CoR plays important role in cellular homeostasis in various tissues, therefore, we hypothesized that an APL like MCDL of N-CoR might also be involved in other malignancy. Indeed, our initial screening of N-CoR status in various leukemia and solid tumor cells revealed an APL like MCDL of N-CoR in primary and secondary tumor cells derived from non-small cell lung cancer (NSCLC). The NSCLC cell specific N-CoR loss could be blocked by Kaletra, a clinical grade protease inhibitor and by genistein, an inhibitor of N-CoR misfolding previously characterized by us. The misfolded N-CoR presented in NSCLC cells was linked to the amplification of ER stress and was subjected to degradation by NSCLC cell specific aberrant protease activity. In NSCLC cells, misfolded N-CoR was found to be associated with Hsc70, a molecular chaperone involved in chaperone mediated autophagy (CMA). Genetic and chemical inhibition of Lamp2A, a rate limiting factor of CMA, significantly blocked the loss of N-CoR in NSCLC cells, suggesting a crucial role of CMA in N-CoR degradation. These findings identify an important role of CMA-induced degradation of misfolded N-CoR in the neutralization of ER stress and suggest a possible role of misfolded N-CoR protein in the activation of oncogenic survival pathway in NSCLC cells.

A: Which is the receptor for substrates of Chaperone Mediated Autophagy?
****
Q: The Raytown Branch of Mid-Continent Public Library is offering the following activities for the month of March. The library is located at 6131 Raytown Road. All activities are free, but registration is required. Tax Help for Seniors 10 a.m. Mondays and Wednesdays. AARP Tax-Aide representatives will be at the Library to assist seniors with medium to low incomes with tax questions and free tax return preparation. Time listed indicates starting time. Teen Games 2 p.m. March 2. Challenge yourself, challenge your friends. Movie Classics For adults, 2 p.m. March 4. Join us for an afternoon of nostalgia as we watch classic films. Call to see what's showing. KC Zoomobile Africa, for ages 5 and older, 11 a.m. March 5. Join the Kansas City Zoo for an African adventure. We will share African culture as well as show you an animal or two. Come with us to learn something new about Africa. Kids at the Library For ages 6 and older, 11 a.m. March 12. Discover, create, and play. Explore big ideas in a new way. Chess Free Play For ages 6 and older, 1 p.m. March 12. Play chess, learn the basics, brush up on your chess skills, challenge other players at Free Chess Play at the library. The Raytown Branch, in cooperation with the Raytown High School Chess Team coaches, will be hosting chess on the second Saturday of the month from 1 to 3 p.m. Chess boards and chess pieces will be provided. Eggstravaganza Noon March 26. Join us for story time with Mayor Mike McDonough, as we take part in Raytown's Easter festivities. After the stories, the Easter Bunny will escort the children across the street for an Easter egg hunt.

A: Which activity is more likely to develop imagination and creativity?
****
Q: Mutations in the solute carrier family 9, subfamily A member 6 (SLC9A6) gene, encoding the endosomal Na+/H+ exchanger 6 (NHE6) are associated with Christianson syndrome, a syndromic form of X-linked intellectual disability characterized by microcephaly, severe global developmental delay, autistic behavior, early onset seizures and ataxia. In a 7-year-old boy with characteristic clinical and neuroimaging features of Christianson syndrome and epileptic encephalopathy with continuous spikes and waves during sleep, we identified a novel splice site mutation (IVS10-1G>A) in SLC9A6. These findings expand the clinical spectrum of the syndrome and indicate NHE6 dysfunction as a new cause of electrical status epilepticus during slow-wave sleep (ESES).

A:
Mutation of which gene is implicated in the Christianson syndrome?
****