Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Example Input: Context: Ion Assault is a multidirectional shooter video game developed by Coreplay and published by Black Inc. for the Xbox Live Arcade, PlayStation Network, and Microsoft Windows. 
 Question: Who worked on Ion Assault?
Example Output: coreplay

Example Input: Context: NeXTSTEP (also stylized as NeXTstep, NeXTStep, and NEXTSTEP) is a combination of several parts: a Unix operating system based on the Mach kernel, plus source code from BSD Display PostScript and a proprietary windowing engine the Objective-C language and runtime an object-oriented (OO) application layer, including several ''kits'' development tools for the OO layers NeXTSTEP is notable for having been a preeminent implementation of the latter three items. 
 Question: What is the programming language for NeXTSTEP?
Example Output: objective-c

Example Input: Context: Reactive oxygen species (ROS) production by NADPH oxidase 1 (NOX1), which is mainly expressed in colon epithelial cells, requires the membrane-bound component p22(PHOX) and the cytosolic partners NOX organizer 1 (NOXO1), NOX activator 1 (NOXA1), and Rac1. Contrary to that of its phagocyte counterpart NOX2, the molecular basis of NOX1 regulation is not clear. Because NOXO1 lacks the phosphorylated region found in its homolog p47(PHOX), the current view is that NOX1 activation occurs without NOXO1 phosphorylation. Here, however, we demonstrate that phorbol myristate acetate (PMA) stimulates NOXO1 phosphorylation in a transfected human embryonic kidney (HEK) 293 epithelial cell model via protein kinase C and identify Ser-154 as the major phosphorylated site. Endogenous NOXO1 from T84 colon epithelial cells was also phosphorylated, suggesting that NOXO1 phosphorylation is physiologically relevant. In transfected HEK-293 cells, PMA-induced phosphorylation on Ser-154 enhanced NOXO1 binding to NOXA1 (+97%) and to the p22(PHOX) C-terminal region (+384%), increased NOXO1 colocalization with p22(PHOX), and allowed optimal ROS production by NOX1 as demonstrated by the use of S154A and S154D mutants compared with that by wild-type NOXO1 (P<0.05). Pulldown experiments revealed that phos-phorylation on Ser-154 was sufficient to markedly enhance NOXO1 binding to NOXA1, which in turn acts as a molecular switch, allowing optimal interaction of NOXO1 with p22(PHOX). This study unexpectedly revealed that full assembly and activation of NOX1 is a tightly regulated process in which NOXO1 phosphorylation on Ser-154 is the initial trigger. 
 Question: Which NADPH oxidase family member requires interaction with NOXO1 for function?
Example Output:
nadph oxidase 1