Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Ex Input:
Context: In the present study, we tested the hypothesis that having migraine in middle age is related to late-life parkinsonism and a related disorder, restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED). The AGES-Reykjavik cohort (born 1907-1935) has been followed since 1967. Headaches were classified based on symptoms assessed in middle age. From 2002 to 2006, 5,764 participants were reexamined to assess symptoms of parkinsonism, diagnosis of Parkinson disease (PD), family history of PD, and RLS/WED. Subjects with midlife migraine, particularly migraine with aura (MA), were in later life more likely than others to report parkinsonian symptoms (odds ratio [OR]MA = 3.6 [95% CI 2.7-4.8]) and diagnosed PD (ORMA = 2.5 [95% CI 1.2-5.2]). Women with MA were more likely than others to have a parent (ORMA = 2.26 [95% CI 1.3-4.0]) or sibling (ORMA = 1.78 [95% CI 1.1-2.9]) with PD. Late-life RLS/WED was increased for headache generally. Associations were independent of cardiovascular disease and MRI-evident presumed ischemic lesions. These findings suggest there may be a common vulnerability to, or consequences of, migraine and multiple indicators of parkinsonism. Additional genetic and longitudinal observational studies are needed to identify candidate pathways that may account for the comorbid constellation of symptoms. 
 Question: Willis-Ekbom disease is also known as?

Ex Output:
restless legs syndrome


Ex Input:
Context: Facioscapulohumeral muscular dystrophy (FSHD) is one of the most prevalent adult muscular dystrophies. The common clinical signs usually appear during the second decade of life but when the first molecular dysregulations occur is still unknown. Our aim was to determine whether molecular dysregulations can be identified during FSHD fetal muscle development. We compared muscle biopsies derived from FSHD1 fetuses and the cells derived from some of these biopsies with biopsies and cells derived from control fetuses. We mainly focus on DUX4 isoform expression because the expression of DUX4 has been confirmed in both FSHD cells and biopsies by several laboratories. We measured DUX4 isoform expression by using qRT-PCR in fetal FSHD1 myotubes treated or not with an shRNA directed against DUX4 mRNA. We also analyzed DUX4 downstream target gene expression in myotubes and fetal or adult FSHD1 and control quadriceps biopsies. We show that both DUX4-FL isoforms are already expressed in FSHD1 myotubes. Interestingly, DUX4-FL expression level is much lower in trapezius than in quadriceps myotubes, which is confirmed by the level of expression of DUX4 downstream genes. We observed that TRIM43 and MBD3L2 are already overexpressed in FSHD1 fetal quadriceps biopsies, at similar levels to those observed in adult FSHD1 quadriceps biopsies. These results indicate that molecular markers of the disease are already expressed during fetal life, thus opening a new field of investigation for mechanisms leading to FSHD. 
 Question: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?

Ex Output:
fshd


Ex Input:
Context: When you take a walk along a beach, what do you find there? Sand, the ocean, lots of sunlight. You may also find shells. The shells you find are most likely left by organisms in the phylum Mollusca. On the beach, you can find the shells of many different mollusks ( Figure 1.1), including clams, mussels, scallops, oysters, and snails. Mollusks are invertebrates that usually have a hard shell, a mantle, and a radula. Their glossy pearls, mother of pearl, and abalone shells are like pieces of jewelry. Some mollusks, such as squid and octopus, do not have shells. The Mollusks body is often divided into different parts ( Figure 1.2): On the beach, you can find a wide variety of mollusk shells. 1. A head with eyes or tentacles. 2. In most species, a muscular foot, which helps the mollusk move. Some mollusks use the foot for burrowing into the sand, and others use it for jet-propulsion. 3. A mantle, or fold of the outer skin lining the shell. The mantle often releases calcium carbonate, which creates an external shell, just like the ones you find on the beach. The shell is made of chitin, a tough, semitransparent substance. 4. A mass housing the organs. 5. A complete digestive tract that begins at the mouth and runs to the anus. 6. Most ocean mollusks have a gill or gills to absorb oxygen from the water. 7. Many species have a feeding structure, the radula, found only in mollusks. The radula can be thought of as a "tongue-like" structure. The radula is made mostly of chitin. Types of radulae range from structures used to scrape algae off of rocks to the beaks of squid and octopuses. This is the basic body plan of a mollusk. Note the mantle, gills, and radula. Keep in mind the basic body plan can differ slightly among the mollusks. Mollusks are probably most closely related to organisms in the phylum Annelida, also known as segmented worms. This phylum includes the earthworm and leech. Scientists believe these two groups are related because, when they are in the early stage of development, they look very similar. Mollusks also share features of their organ systems with segmented worms. Unlike segmented worms, however, mollusks do not have body segmentation. The basic mollusk body shape is usually quite different as well. 
 Question: the foot of a squid is probably used for

Ex Output:

jet-propulsion.