Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

Paragraph: The analysis suggests the potentially harmful effect of Celebrex dosage is most pronounced in higher-risk patients, researchers said at the American College of Cardiology scientific meeting. “Patients at low cardiovascular risk should take some level of comfort,” said Dr. Scott Solomon, lead researcher of the National Cancer Institute-sponsored analysis. “That wasn’t so clear previously.”   Doctors should exercise caution in prescribing the drug, generally known as celecoxib, in high-risk patients, said Solomon, whose analysis was also published online in the journal Circulation. Celebrex belongs to a class of pain drugs known as cox-2 inhibitors and is the only such drug still on the market in the United States. Merck and Co Inc withdrew its widely used cox-2 drug, Vioxx, from the market in 2004 after a study showed it doubled the risk of heart attack and stroke in long- term users. Another cox-2 inhibitor from Pfizer called Bextra was also pulled from the U.S. market due to safety concerns. While the analysis sheds light on how the drug should be used, Solomon said he could not judge whether the data lift the cloud over this class of drugs. The six trials involving a total of 7,950 patients all studied Celebrex against a placebo for uses other than arthritis. Patients received either 400 milligrams once a day, 200 mg twice a day, or 400 mg twice a day. The primary goal of the pooled analysis was an assessment of the combined risk of cardiovascular death, heart attack, stroke, heart failure or events involving blood clots. Researchers found the heart risk was lowest at the 400 mg daily dose. They found nearly a two-fold risk of adverse heart events with the 200 mg twice daily dose and that jumped to about a three-fold risk at the 400 mg twice daily dose. “Even 400 mg once a day showed elevated risk” in the high-risk population, Solomon said, adding he could not extrapolate whether doses lower than 400 mg cut risk further. The increased risk was not affected by aspirin use, researchers said. “Most of the data used in this pooled analysis have previously been published and are consistent with what we already know about the cardiovascular risks of Celebrex and other prescription arthritis pain relievers,” said Gail Cawkwell, Pfizer’s executive medical director. “The analysis doesn’t provide any new conclusions on the FDA-approved doses of Celebrex, including the most commonly prescribed dose of 200 mg daily,” she said. Dr. Steven Nissen of the Cleveland Clinic, who has a study on lower doses underway, added: “There aren’t long-term randomized placebo-controlled trials for that dose, The only way we’re ever going to answer these questions is with good randomized prospective data,” he said. “We’ll tell it like it is when the data is in.” Claim: Celebrex risky in high-risk patients, study finds.
Doctors should prescribe the lowest doses of Celebrex possible in patients at high risk of heart problems, researchers who did a combined analysis of six studies of the Pfizer Inc pain drug said on Monday.

Paragraph: Yet nothing prepared residents of its oldest town, Graaff-Reinet, for their worst drought in more than a century. As the dry spell entered its fourth year, tap water turned brown and smelled like rotting fish. When the water behind the Nqweba Dam dried up, depositing tens of thousands of dead fish onto cracked earth, queues began forming at municipal bore holes and farm animals died in their hundreds. The bleak choices facing millions of people in drought-stricken southern Africa - whether to flush toilets or not, or to keep animals alive or let them die - could soon be faced by other places on a warming planet with shrinking water supplies. “This area is dry but our taps have never been completely empty. Never,” said Bukelwa Booysen, who has had to send staff in search of borehole water for her school for disabled children, and send the kids home when they can’t find any. An abnormally hot summer with rainfall 75% below average, according to the U.S. National Oceanic and Atmospheric Administration, has struck the whole region. The United Nations says 45 million people in southern Africa face hunger. Bushes and trees clinging to the Karoo’s rocky ravines are withered and grey - even hardy acacia thorns are dying. Signs mark rivers that are now dry beds. At one farm, Gerrie Snyman, 65, was feeding grain to sheep and goats that couldn’t find pasture. More than a third of his couple-thousand goats and sheep had either died or been sold this year. His 80 cows were now 15. He loaded a calf that was starving - its mother had stopped producing milk - onto his truck to take home and shoot. A friend had shot himself dead after his animals died of thirst. “We are grateful to the Almighty for our borehole water,” he said. “We don’t know what we’ll do when it runs out.”   When Cape Town’s reservoir nearly ran dry 18 months ago, it made international headlines and authorities rationed water. Yet Karoo is long past water rationing. For Valentia Esho, 45, an unemployed mother of seven in the township of Umazisakhe, it means letting her toilet fill up  instead of flushing, never washing clothes and only washing plates that stink. Water is just for drinking. “The house is really smelling,” she said, inside her one-room brick-and-tin home. “Everyone is paining from stomach aches and diarrhoea.”   In another township, Asherville, where wind kicked up dust devils, school headmaster Basil Vaaltyn was overseeing water distribution from a truck. He’d done everything to cut down on his usage: “I’m down to a minute showering instead of two.” His wife saves dirty dishwater to fill the cistern. A spokesman for the municipality said it was drilling boreholes, installing pipelines and building an 18-million-litre reservoir, adding: “Usage of water is still very high. The community is requested to use water sparingly.”  With municipal authorities overwhelmed, South African charity Gift of the Givers is trucking water to townships and drilling boreholes. Gideon Groenewald, a geohydrologist for the charity, uses science and spirituality to look for groundwater. When he was growing up on a farm, he used to dowse with wet twigs. Nowadays he prefers magnetic detectors. “I open Google maps and look for the lines of trees. I ask God in prayer which lines hold water, then I go down to that GPS location,” he said while a forked stick turned in his hand over an arid patch of shrubs. “You see the stick moving where the magnetic field is? There’s water here,” he continued. “It’s pure science.”  The charity has drilled 1,800 boreholes in the past three years, Groenewald said, only a third of them dry. But Louise Stafford, water director for the Nature Conservancy in South Africa, urged caution with boreholes, because groundwater is a finite resource. Water-intensive agriculture like citrus farms can make droughts worse, she said, and leaky pipes are losing a billion litres a year - problems Water Minister Lindiwe Sisulu pledged to tackle in a new water masterplan she delivered on Thursday. One Sunday, as clouds formed over Graaff-Reinet, its Assembly Church prayed. The clouds spat but didn’t pour. “We pray for God to open heaven and send rain,” Pastor Dolan Cochrane said. The congregation bowed. “Lord,” Cochrane continued. “We know that, in your time, you will come to our rescue.” Claim: South Africa's Karoo drills and prays as taps run dry.
South Africa’s Karoo region has always been parched - it means land of thirst in the language of its earliest inhabitants, the Khoisan hunter gatherers.

Paragraph: Tedros Adhanom Ghebreyesus was speaking Monday at the start of the World Health Organization’s annual assembly, where issues like anti-microbial resistance, universal health care and WHO reform are among the topics up for discussion. Ghebreyesus noted that the current Ebola outbreak, which is the second deadliest on record and has been confirmed to have taken nearly 1,100 lives, is so far contained to two provinces of eastern Congo that are wracked by violence by armed groups. He said the outbreak was “one of the most complex health emergencies any of us have ever faced.” Claim: UN health chief warns of ‘very high’ risk of Ebola spread.

The head of the U.N. health agency says the risk that the Ebola virus will spread remains “very high.”