In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Ex Input:
Question: In a determination of the activity of an enzyme, the depletion of the substrate: 
 Options:  <1> It is essential for most trials. <2> It may give falsely low results in sera with high enzymatic activity. <3> It occurs when the reagent is finished. <4> It occurs due to a defect in the spectrophotometer. <5> It can lead to falsely elevated results in sera with high enzymatic activity.

Ex Output:
2


Ex Input:
Question: The reaction of an alkene with metachloroperbenzoic acid causes a cyclic ether which is called: 
 Options:  <1> Furano <2> Dioxane <3> Epoxide <4> Azirano <5> Lactone

Ex Output:
3


Ex Input:
Question: The folded sheet β: 
 Options:  <1> It is formed by a single polypetide chain. <2> It presents a distance between adjacent amino acids of approximately 4 ångströms. <3> It is formed by the union of two or more strands by hydrogen bonds. <4> Presents the side chains of contiguous amino acids pointing to the same side. <5> They are of two types: parallel, where the chains of the β sheet go in a different direction and antiparallel, where they go in the same direction.

Ex Output:

3