In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Paragraph: Reproductive success in the eight founder strains of the Collaborative Cross (CC) was measured using a diallel-mating scheme. Over a 48-month period we generated 4,448 litters, and provided 24,782 weaned pups for use in 16 different published experiments. We identified factors that affect the average litter size in a cross by estimating the overall contribution of parent-of-origin, heterosis, inbred, and epistatic effects using a Bayesian zero-truncated overdispersed Poisson mixed model. The phenotypic variance of litter size has a substantial contribution (82%) from unexplained and environmental sources, but no detectable effect of seasonality. Most of the explained variance was due to additive effects (9.2%) and parental sex (maternal vs. paternal strain; 5.8%), with epistasis accounting for 3.4%. Within the parental effects, the effect of the dam's strain explained more than the sire's strain (13.2% vs. 1.8%), and the dam's strain effects account for 74.2% of total variation explained. Dams from strains C57BL/6J and NOD/ShiLtJ increased the expected litter size by a mean of 1.66 and 1.79 pups, whereas dams from strains WSB/EiJ, PWK/PhJ, and CAST/EiJ reduced expected litter size by a mean of 1.51, 0.81, and 0.90 pups. Finally, there was no strong evidence for strain-specific effects on sex ratio distortion. Overall, these results demonstrate that strains vary substantially in their reproductive ability depending on their genetic background, and that litter size is largely determined by dam's strain rather than sire's strain effects, as expected. This analysis adds to our understanding of factors that influence litter size in mammals, and also helps to explain breeding successes and failures in the extinct lines and surviving CC strains. KEYWORDS 
 Title: A Diallel of the Mouse Collaborative Cross Founders Reveals Strong Strain-Specific Maternal Effects on Litter Size
False

Paragraph: Rational design of proteins with novel binding specificities and increased affinity is one of the major goals of computational protein design. Epitope-scaffolds are a new class of antigens engineered by transplanting viral epitopes of pre-defined structure to protein scaffolds, or by building protein scaffolds around such epitopes. Epitope-scaffolds are of interest as vaccine components to attempt to elicit neutralizing antibodies targeting the specified epitope. In this study we developed a new computational protocol, MultiGraft Interface, that transplants epitopes but also designs additional scaffold features outside the epitope to enhance antibody-binding specificity and potentially influence the specificity of elicited antibodies. We employed MultiGraft Interface to engineer novel epitope-scaffolds that display the known epitope of HIV-1 neutralizing antibody 2F5 and that also interact with the functionally important CDR H3 antibody loop. MultiGraft Interface generated an epitope-scaffold that bound 2F5 with sub-nanomolar affinity (K D = 400 pM) and that interacted with the antibody CDR H3 loop through computationally designed contacts. Substantial structural modifications were necessary to engineer this antigen, with the 2F5 epitope replacing a helix in the native scaffold and with 15% of the native scaffold sequence being modified in the design stage. This epitope-scaffold represents a successful example of rational protein backbone engineering and protein-protein interface design and could prove useful in the field of HIV vaccine design. MultiGraft Interface can be generally applied to engineer novel binding partners with altered specificity and optimized affinity. § 
 Title: Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5 HHS Public Access
False

Paragraph: publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. The term 'emerging infectious diseases' (EIDs) is a broad one that covers newly recognized human diseases caused by pathogens that have recently jumped species, older pathogens that have emerged in new populations due to human behaviors or modifications to natural habitats, and older pathogens that are exhibiting resurgence in areas once brought under control, usually due to microbiological adaptation and change; this includes previously-identified microorganisms exhibiting new patterns of antimicrobial drug resistance and pathogenic properties. Emerging infectious diseases are those with increasing incidence at local, regional, or international scales, and are spreading from epicenters to new geographic areas. The surveillance, study and control of EIDs is a complex interdisciplinary effort, crossing international borders and involving the collaborative efforts of scientists, clinicians, and political leaders from many disciplines and backgrounds to protect human health. According to a comprehensive literature review performed by Taylor et al. (2001) at the Centre for Tropical Veterinary Medicine at the University of Edinburgh, 1415 species of infectious organisms known to be pathogenic to humans were identified. The human pathogens tabulated by this study included an assortment of 217 viruses and prions, 538 bacteria and rickettsia, 307 fungi, 66 protozoa and 287 helminths. The majority of these (61%) were zoonotic infections transmitted from animals to humans. Of the 175 pathogenic species associated with diseases considered to be 'emerging', 135 (75%) were zoonotic. The study found that protozoan and virus pathogens were particularly likely to emerge, and that the helminths were less likely to do so. Interestingly, no association was found between route of transmission and emergence in this study. An updated literature survey from the Centre for Infectious Diseases at the same institution (University of Edinburgh) was published in 2005 by Woolhouse and Gowtage-Sequeria. This study identified 1407 species of human pathogens, 58% of which were zoonotic. Of the total, 177 were regarded as 'emerging' or 're-emerging' pathogens. The emerging and re-emerging zoonotic pathogens were most likely to have the broadest host ranges. The authors noted that although zoonotic pathogens constitute a significant source for emerging and re-EIDs, only a small minority of them would prove capable of causing major epidemics in the human population -but the H5N1 influenza strain could prove to be an exception. Causal factors contributing to the emergence of new pathogens include human population growth resulting in human encroachment on wildlife habitats, increased human contact with domestic and wild animals, changes in agricultural practices CHAPTER 3 sECTion 1 ä PRE-TRAvEl AdviCE 
 Title: Emerging Diseases and the International Traveler

True