Given two noun phrases (arguments) and relationship between them, form a sentence that expresses theses arguments with the given relationship.

Q: Relationship: 'be city in', Argument/Subject 1: 'siena', Argument/Subject 2: 'tuscany'

A: Siena is one of the leading art cities in Tuscany .
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Q: Relationship: 'be bear in', Argument/Subject 1: 'smith', Argument/Subject 2: 'scotland'

A: SMITH , ROBERT BARR , businessman and philanthropist , was born on 4 February 1824 at Lochwinnoch , Renfrewshire , Scotland , son of Rev. Dr Robert Smith , Church of Scotland minister , and his wife Marjory , n?e Barr .
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Q: Relationship: 'be city in', Argument/Subject 1: 'santiago de cuba', Argument/Subject 2: 'cuba'

A:
Havana is Cuba 's largest city , nearly five times larger than the next largest city , Santiago de Cuba , whose population numbers about 400,000 .
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