Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: The effect of the newly synthesized compound 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400) on the Na+-Ca2+ exchanger (NCX) was investigated and compared against that of 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea (KB-R7943). In addition, the effects of SEA0400 on reperfusion injury in vitro and in vivo were examined. SEA0400 was extremely more potent than KB-R7943 in inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia: IC50s of SEA0400 and KB-R7943 were 5 to 33 nM and 2 to 4 microM, respectively. SEA0400 at the concentration range that inhibited NCX exhibited negligible affinities for the Ca2+ channels, Na+ channels, K+ channels, norepinephrine transporter, and 14 receptors, and did not affect the activities of the Na+/H+ exchanger, Na+,K+-ATPase, Ca2+-ATPase, and five enzymes. SEA0400, unlike KB-R7943, did not inhibit the store-operated Ca2+ entry in cultured astrocytes. SEA0400 attenuated dose- dependently paradoxical Ca2+ challenge-induced production of reactive oxygen species, DNA ladder formation, and nuclear condensation in cultured astrocytes, whereas it did not affect thapsigargin-induced cell injury. Furthermore, administration of SEA0400 reduced infarct volumes after a transient middle cerebral artery occlusion in rat cerebral cortex and striatum. These results indicate that SEA0400 is the most potent and selective inhibitor of NCX, and suggest that the compound may exert protective effects on postischemic brain damage.
Example Output: The small molecule SEA0400 is an inhibitor of which ion antiporter/exchanger?

Example Input: Two forms of neurofibromatosis, type 1 (NF1) and type 2 (NF2) are connected with genes localized on chromosomes 17 and 22, respectively. The genes that are inactivated in neurofibromatosis code for the proteins neurofibromine and merline, respectively. Since inactivation leads to neoplasia, they are called tumour suppressor genes. Neurofibromine shows resemblances to proteins that serve to inactivate oncogenes. Merline has a relationship with proteins that connect the cytoskeleton and the cell membrane. The precise function of the proteins is still unknown. The NF1 gene is characterized by extraordinarily high sensitivity to mutation; half the NF1 patients have not inherited the disease. In the familial form of neurofibromatosis, a mutated gene is inherited and the normal allele in the tumour is inactivated, making tumour growth possible. In the sporadic form of neurofibromatosis, both normal alleles are inactivated locally in the tissue so that a tumour develops in that place.
Example Output: Which is the gene mutated in type 1 neurofibromatosis?

Example Input: Radioactivity is the tendency of certain atoms to decay into lighter atoms, a process that emits energy. Radioactivity also provides a way to find the absolute age of a rock. First, we need to know about radioactive decay. Some isotopes are radioactive; radioactive isotopes are unstable and spontaneously change by gaining or losing particles. Two types of radioactive decay are relevant to dating Earth materials (Table 1.1): Particle Alpha Composition 2 protons, 2 neutrons Beta 1 electron Effect on Nucleus The nucleus contains two fewer protons and two fewer neutrons. One neutron decays to form a pro- ton and an electron. The electron is emitted. The radioactive decay of a parent isotope (the original element) leads to the formation of stable daughter product, also known as daughter isotope. As time passes, the number of parent isotopes decreases and the number of daughter isotopes increases (Figure 1.1). Radioactive materials decay at known rates, measured as a unit called half-life. The half-life of a radioactive substance is the amount of time it takes for half of the parent atoms to decay. This is how the material decays over time (see Table 1.2). No. of half lives passed 0 1 2 3 4 5 6 7 8 Percent parent remaining 100 50 25 12.5 6.25 3.125 1.563 0.781 0.391 Percent daughter produced 0 50 75 87.5 93.75 96.875 98.437 99.219 99.609 Pretend you find a rock with 3.125% parent atoms and 96.875% daughter atoms. How many half lives have passed? If the half-life of the parent isotope is 1 year, then how old is the rock? The decay of radioactive materials can be shown with a graph (Figure 1.2). Notice how it doesnt take too many half lives before there is very little parent remaining and most of the isotopes are daughter isotopes. This limits how many half lives can pass before a radioactive element is no longer useful for Decay of an imaginary radioactive sub- stance with a half-life of one year. dating materials. Fortunately, different isotopes have very different half lives. Click image to the left or use the URL below. URL:
Example Output:
radioactive decay of an isotope leads to the formation of a ____________ product.