instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: Viruses, the molecular nanomachines infecting hosts ranging from prokaryotes to eukaryotes, come in different sizes, shapes and symmetries. Questions such as what principles govern their structural organization, what factors guide their assembly, how these viruses integrate multifarious functions into one unique structure have enamored researchers for years. In the last five decades, following Caspar and Klug's elegant conceptualization of how viruses are constructed, high resolution structural studies using X-ray crystallography and more recently cryo-EM techniques have provided a wealth of information on structures of variety of viruses. These studies have significantly furthered our understanding of the principles that underlie structural organization in viruses. Such an understanding has practical impact in providing a rational basis for the design and development of antiviral strategies. In this chapter, we review principles underlying capsid formation in a variety of viruses, emphasizing the recent developments along with some historical perspective. -barrel fold; HK97-like fold; Double -barrel trimer Often the size of the virus is proportional to the size of the genome. However, the viral genome contributes far less to the total mass of the virion than the capsid proteins. It was NIH Public Access 
 Title: Principles of Virus Structural Organization
answer:
True


question:
Paragraph: Saffold virus (SAFV) is classified into the Cardiovirus genus of the Picornaviridae family. Up to now, eleven genotypes have been identified however, their clinical significance remains unclear. Here, we investigated the presence of SAFV in asymptomatic patients admitted for adenoidectomy. A total of 70 adenoid tissue samples were collected from children with clinical symptoms caused by hypertrophy of adenoids but without symptoms of airway infection. Samples were investigated for SAFV by RT-nested PCR and sequence analysis. Eleven of 70 (15.7%) samples were positive for SAFV. Nasopharyngeal swabs were available from 45 children just before surgery. SAFV was rarely found and only in children with SAFV-positive adenoids 2/8. Our findings indicate that the presence of SAFV seems to be more frequent in adenoid tissue than expected. This could support the notion of a longer than previously anticipated persistence of SAFV nucleic acids in the respiratory tract and possibly a chronic infection. Further investigations are necessary to establish the role of SAFV infection in humans. 
 Title: Frequent detection of Saffold cardiovirus in adenoids
answer:
True


question:
Paragraph: China reported zero locally-acquired malaria cases in 2017 and 2018. Understanding the spatio-9 temporal pattern underlying this decline, especially the relationship between locally-acquired and 10 imported cases, can inform efforts to maintain elimination and prevent re-emergence. This is 11 particularly pertinent in Yunnan province, where the potential for local transmission is highest. Using 12 a geo-located individual-level dataset of cases recorded in Yunnan province between 2011 and 2016, 13 we jointly estimate the case reproduction number, , and the number of unobserved sources of 14 infection. We use these estimates within spatio-temporal geostatistical models to map how 15 transmission varied over time and space, estimate the timeline to elimination and the risk of 16 resurgence. Our estimates suggest that, maintaining current intervention efforts, Yunnan is unlikely 17 to experience sustained local transmission up to 2020. However, even with a mean of 0.005 18 projected for the year 2019, locally-acquired cases are possible due to high levels of importation. 
 Title: Tracking progress towards malaria elimination in China: estimates of 1 reproduction numbers and their spatiotemporal variation 2 3
answer:

False