In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Example Input: Paragraph: Aquaporins are small channel proteins which facilitate the diffusion of water and small neutral molecules across biological membranes. Compared with animals, plant genomes encode numerous aquaporins, which display a large variety of subcellular localization patterns. More specifically, plant aquaporins of the plasma membrane intrinsic protein (PIP) subfamily were first described as plasma membrane (PM)-resident proteins, but recent research has demonstrated that the trafficking and subcellular localization of these proteins are complex and highly regulated. In the past few years, PIPs emerged as new model proteins to study subcellular sorting and membrane dynamics in plant cells. At least two distinct sorting motifs (one cytosolic, the other buried in the membrane) are required to direct PIPs to the PM. Hetero-oligomerization and interaction with SNAREs (soluble N-ethylmaleimide-sensitive factor protein attachment protein receptors) also influence the subcellular trafficking of PIPs. In addition to these constitutive processes, both the progression of PIPs through the secretory pathway and their dynamics at the PM are responsive to changing environmental conditions. The first aquaporins discovered in plants were classified on the basis of their subcellular localization. NIPs (nodulin26-like 
 Title: Trafficking of Plant Plasma Membrane Aquaporins: Multiple Regulation Levels and Complex Sorting Signals
Example Output: False

Example Input: Paragraph: Danhong injection (DHI) is a widely used Chinese Materia Medica standardized product for the clinical treatment of ischemic encephalopathy and coronary heart disease. The bindings of eight natural components in DHI between bovine serum albumin (BSA) were studied by fluorescence spectroscopy technology and molecular docking. According to the results, the quenching process of salvianolic acid B and hydroxysafflor yellow A was a static quenching procedure through the analysis of quenching data by the Stern-Volmer equation, the modified Stern-Volmer equation, and the modified Scatchard equation. Meanwhile, syringin (Syr) enhanced the fluorescence of BSA, and the data were analyzed using the Lineweaver-Burk equation. Molecular docking suggested that all of these natural components bind to serum albumin at the site I location. Further competitive experiments of SaB confirmed the result of molecular docking studies duo to the displacement of warfarin by SaB. Base on these studies, we selected SaB as a research target because it presented the strongest binding ability to BSA and investigated the influence of the multi-components coexisting in DHI on the interaction between the components of the SaB-BSA binding system. The participation of these natural components in DHI affected the interaction between the components of the SaB-BSA system. Therefore, when DHI is used in mammals, SaB is released from serum albumin more quickly than it is used alone. This work would provide a new experiment basis for revealing the scientific principle of compatibility for Traditional Chinese Medicine. 
 Title: Interaction between the Natural Components in Danhong Injection (DHI) with Serum Albumin (SA) and the Influence of the Coexisting Multi-Components on the SaB-BSA Binding System: Fluorescence and Molecular Docking Studies
Example Output: False

Example Input: Paragraph: Self-replicating single-stranded RNA viruses such as alphaviruses, flaviviruses, measles viruses, and rhabdoviruses provide efficient delivery and high-level expression of therapeutic genes due to their high capacity of RNA replication. This has contributed to novel approaches for therapeutic applications including vaccine development and gene therapy-based immunotherapy. Numerous studies in animal tumor models have demonstrated that self-replicating RNA viral vectors can generate antibody responses against infectious agents and tumor cells. Moreover, protection against challenges with pathogenic Ebola virus was obtained in primates immunized with alphaviruses and flaviviruses. Similarly, vaccinated animals have been demonstrated to withstand challenges with lethal doses of tumor cells. Furthermore, clinical trials have been conducted for several indications with self-amplifying RNA viruses. In this context, alphaviruses have been subjected to phase I clinical trials for a cytomegalovirus vaccine generating neutralizing antibodies in healthy volunteers, and for antigen delivery to dendritic cells providing clinically relevant antibody responses in cancer patients, respectively. Likewise, rhabdovirus particles have been subjected to phase I/II clinical trials showing good safety and immunogenicity against Ebola virus. Rhabdoviruses have generated promising results in phase III trials against Ebola virus. The purpose of this review is to summarize the achievements of using self-replicating RNA viruses for RNA therapy based on preclinical animal studies and clinical trials in humans. Molecules 2018, 23, 3310 2 of 22 in the areas of cancer immunotherapy [4,5], vaccine development against infectious diseases [6,7], protein replacement [8], and gene editing [9]. Related to mRNA-based drug approaches, the employment of self-replicating RNA viruses has provided an interesting and attractive alternative to further enhance delivery and efficacy [10] . The unique feature of high-rate cytoplasmic replication combined with extreme transgene expression has made these RNA viruses the system of choice for RNA therapeutics. In this review, self-replicating vectors are described and their applications for preclinical studies and clinical trials are discussed. The common feature of self-replicating RNA viruses relates to their single-stranded RNA (ssRNA) genome surrounded by a capsid core structure and a protein envelope. Alphaviruses [11] and flaviviruses [12] possess a genome of positive polarity, whereas the genome of measles viruses (MVs) [13] and rhabdoviruses [14] as negative strand ssRNA. Expression vectors serving as templates for RNA transcription and recombinant viral particles have been engineered. Moreover, alphavirus vectors providing RNA replication can be utilized as plasmid DNA. 2.1. Alphaviruses Alphaviruses belong to the family of Togaviridiae [15]. The most common alphaviruses engineered as expression vectors are based on Semliki Forest virus (SFV) [15], Sindbis virus (SIN) [16], and Venezuelan equine encephalitis virus (VEE) [17]. The alphavirus genome consists of four nonstructural genes (nsP1-4), responsible for RNA self-replication and the genes for the capsid and envelope proteins [11] (Figure 1A-C). Engineered alphavirus vectors generate replication-deficient and -proficient recombinant particles suitable for transgene expression in cell lines and in vivo [18]. Introduction of a CMV promoter upstream of the nsP genes allows direct transfection of plasmid DNA with self-replicating RNA capacity [19]. Due to the design of these alternative alphavirus vectors it is possible to conduct studies with naked RNA replicons, recombinant viral particles and layered DNA-RNA vectors. Molecules 2018, 23, 3310 2 of 21 cancer immunotherapy [4,5], vaccine development against infectious diseases [6,7], protein replacement [8], and gene editing [9]. Related to mRNA-based drug approaches, the employment of self-replicating RNA viruses has provided an interesting and attractive alternative to further enhance delivery and efficacy [10] . The unique feature of high-rate cytoplasmic replication combined with extreme transgene expression has made these RNA viruses the system of choice for RNA therapeutics. In this review, self-replicating vectors are described and their applications for preclinical studies and clinical trials are discussed. The common feature of self-replicating RNA viruses relates to their single-stranded RNA (ssRNA) genome surrounded by a capsid core structure and a protein envelope. Alphaviruses [11] and flaviviruses [12] possess a genome of positive polarity, whereas the genome of measles viruses (MVs) [13] and rhabdoviruses [14] as negative strand ssRNA. Expression vectors serving as templates for RNA transcription and recombinant viral particles have been engineered. Moreover, alphavirus vectors providing RNA replication can be utilized as plasmid DNA. Alphaviruses belong to the family of Togaviridiae [15]. The most common alphaviruses engineered as expression vectors are based on Semliki Forest virus (SFV) [15], Sindbis virus (SIN) [16], and Venezuelan equine encephalitis virus (VEE) [17]. The alphavirus genome consists of four nonstructural genes (nsP1-4), responsible for RNA self-replication and the genes for the capsid and envelope proteins [11] (Figure 1A-C). Engineered alphavirus vectors generate replication-deficient and -proficient recombinant particles suitable for transgene expression in cell lines and in vivo [18]. Introduction of a CMV promoter upstream of the nsP genes allows direct transfection of plasmid DNA with self-replicating RNA capacity [19] . Due to the design of these alternative alphavirus vectors it is possible to conduct studies with naked RNA replicons, recombinant viral particles and layered DNA-RNA vectors. 
 Title: molecules Self-Replicating RNA Viruses for RNA Therapeutics
Example Output:
True