Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: To evaluate the role of apoptosis in the pathogenesis of brain lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary microangiopathy leading to cognitive decline and dementia, caused by mutations in the NOTCH3 gene. Detection of apoptotic nuclei in temporal lobe, brain stem, medulla oblongata, hippocampus and basal ganglia from one young CADASIL patient was performed by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling (TUNEL). Our results showed a great involvement of glial cells in apoptotic cell death in the majority of the brain regions examined; neuronal apoptosis was significantly present only in the brain stem region. We hypothesized that in the early stages of the disease neuronal involvement of apoptosis is limited to the cells of the brain stem, sparing the cortical area which is involved in neuronal apoptosis and cognitive decline later.

Output: Which gene is involved in CADASIL?


Input: Consider Input: Jo was the first to wake in the gray dawn of Christmas morning. No stockings hung at the fireplace, and for a moment she felt as much disappointed as she did long ago, when her little sock fell down because it was crammed so full of goodies. Then she remembered her mother's promise and, slipping her hand under her pillow, drew out a little red-covered book. She knew it very well, for it was that beautiful old story of the best life ever lived, and Jo felt that it was a true guidebook for any pilgrim going on a long journey. She woke Meg with a "Merry Christmas," and asked her to see what was under her pillow. A green-covered book appeared, with the same picture inside, and a few words written by their mother, which made their one present very precious in their eyes. Presently Beth and Amy woke to find their little books also, one grey-color1ed, the other blue, and all sat looking at and talking about them, while the east grew rosy with the coming day. "Girls," said Meg seriously, "Mother wants us to read and love and mind these books, and we must begin at once. I shall keep my book on the table here and read a little every morning as soon as I wake, for I know it will do me good and help me through the day." Then she opened her new book and began to read. Jo put her arm round her and, leaning cheek to cheek, read also, with the quiet expression so seldom seen on her restless face. Much impressed by the pretty books and her sisters' example, the other two started reading too. And then the rooms were very still while the pages were softly turned, and the winter sunshine crept in to touch the bright heads and serious faces with a Christmas greeting. "Where is Mother?" asked Meg, as she and Jo ran down to thank her for their gifts, half an hour later. "Your ma went straight off to see what was needed in a poor woman's home." Replied Hannah, who had lived with the family since Meg was born, and was considered by them all more as a friend than a servant. "She will be back soon, I think, so fry your cakes, and have everything ready," said Meg, looking over the presents which were collected in a basket and kept under the sofa, ready to be produced at the proper time." "There's Mother. Hide the basket, quick!" cried Jo, as a door slammed and steps sounded in the hall. The girls rushed to the table, eager for breakfast. "Merry Christmas, Mummy! Thank you for our books. We read some, and mean to every day," they all cried happily together. "Merry Christmas, little daughters! I'm glad you began at once, and hope you will keep on. But I want to say one word before we sit down. Not far away from here lies a poor woman with a little newborn baby. Six children are huddled into one bed to keep from freezing, for they have no fire. There is nothing to eat over there, and the oldest boy came to tell me they were suffering hunger and cold. My girls, will you give them your breakfast as a Christmas present?" They were all unusually hungry, having waited nearly an hour, and for a minute no one spoke, only a minute, for Jo exclaimed excitedly, "I'm so glad you came before we began!" Then the four girls put the cream, the muffins and the buckwheat bread into a big basket. "I thought you'd do it," said Mrs. March, smiling as if satisfied." You shall all go and help me, and when we come back we will have bread and milk for breakfast, and make it up at dinner time." They were soon ready, and the procession set out. A poor, bare, miserable room it was, with broken windows, no fire, ragged bedclothes

Output: Who got the green-covered book with a few words written by Mother as a Christmas gift?


Input: Consider Input: Tardive dyskinesia (TD) is a movement disorder characterized by abnormal involuntary facial movements induced by chronic therapy with classical antipsychotic medications. Currently, there is no satisfactory pharmacotherapy for TD, which represents a major limitation to therapy with classical antipsychotics. In order to develop or optimize therapies for TD, and to develop new APDs with lower indices of motor side effects, the pathology underlying TD must first be understood. The use of animal models has been used to further this objective. Here, we review different preparations that have been used to model TD and discuss the contribution of neuroimaging studies conducted in these models. Studies in animal models have lead to several hypotheses of TD pathology, although none has yet emerged as the ultimate underlying cause of this syndrome. We discuss alterations in functional indices, neuron and synapse morphology and changes in specific neurotransmitter systems that have been described in animal models of TD, and outline how these findings have contributed to our understanding of antipsychotic-induced dyskinesias. We conclude that several non-mutually exclusive theories of TD are supported by animal studies, including increases in oxidative stress leading to structural and functional changes in specific neurotransmitter systems. Elucidating the mechanisms underlying TD neuropathology partly through the use of animal models will lead to the development of APDs with superior side effect profiles or more effective therapies for TD.


Output: What is the cause of Tardive dyskinesia?