In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Q: Question: Regarding gastroesophageal reflux disease, which of the following statements is true? 
 Options:  <1> The intensity and frequency of heartburn has little relationship with the presence and severity of endoscopic esophagitis. <2> Most patients with gastroesophageal reflux disease have esophagitis at endoscopy. <3> Treatment with proton pump inhibitors usually achieves good control of symptoms but is not superior to placebo in the endoscopic cure of esophagitis. <4> Barrett's esophagus can progress to low-grade epithelial dysplasia, high-grade epithelial dysplasia, and finally squamous cell carcinoma of the esophagus. <5> Endoscopic screening and surveillance programs have unequivocally shown to be able to reduce mortality in patients with Barrett's esophagus.

A: 1
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Q: Question: Question linked to image no. 5 A 41-year-old man referred for presenting for more than 5 years bilateral alternating gluteal pain predominantly nocturnal, which interferes with sleep and relieves with mobilization. It is accompanied by stiffness for more than 1 hour after inactivity. Denies pain, swelling or deformity to another level. It provides elementary analytics without alterations except PCR 11.5 mg / dl (N <5) and the attached radiograph. The objective radiological alteration and the most probable diagnosis would be: 
 Options:  <1> Fracture of Looser- Osteomalacia. <2> Bilateral sacroiliitis - Ankylosing spondylitis. <3> Coexistence of lytic and blastic lesions Paget's disease. <4> Blastic lesions - Prostatic adenocarcinoma with bone metastases. <5> Osteosclerosis - Lymphoma.

A: 2
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Q: Question: A study is carried out to investigate the association between factor X and disease Z. To do this, 120 subjects with the disease and 420 controls (without the disease) are matched by age and sex. In both groups it is found that 20 subjects were exposed to factor X. What is the odds ratio (OR) between factor X and disease Z? 
 Options:  <1> OR = 1 (no association). <2> OR = 2. <3> OR = 4 <4> OR = 6 <5> OR = 8

A:
3
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