instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: Ca2+ is a ubiquitous intracellular messenger responsible for controlling numerous cellular processes including fertilization, mitosis, neuronal transmission, contraction and relaxation of muscles, gene transcription, and cell death. At rest, the cytoplasmic Ca2+ concentration [Ca2+]i is approximately 100 nM, but this level rises to 500-1,000 nM upon activation. In osteoblasts, the elevation of [Ca2+]i is a result of an increase in the release of Ca2+ from endoplasmic reticulum and/or extracellular Ca2+ influx through voltage gated Ca2+ channels. Many of the cellular effects of Ca2+ are mediated by the Ca2+ binding protein, calmodulin (CaM). Upon binding up to four calcium ions, CaM undergoes a conformational change, which enables it to bind to specific proteins eliciting a specific response. Calmodulin kinase II (CaMKII) is a major target of the Ca(2+)/CaM second messenger system. Once bound to Ca(2+)/CaM, the multimeric CaMKII is released from its autoinhibitory status and maximally activated, which then leads to an intraholoenzyme autophosphorylation reaction. Calcineurin (Cn) is another major target protein that is activated by Ca(2+)/CaM. Cn is a serine-threonine phosphatase that consists of a heterodimeric protein complex composed of a catalytic subunit (CnA) and a regulatory subunit (CnB). Upon activation, Cn directly binds to, and dephosphorylates nuclear factor of activated T cells (NFAT) transcription factors within the cytoplasm allowing them to translocate to the nucleus and participate in the regulation of gene expression. This review will examine the potential mechanisms by which calcium, CaM, CaMKII, and Cn/NFAT control osteoblast proliferation and differentiation. 
 Question: Which calcium/calmodulin dependent protein phosphatase is involved in the activation of the family of NFAT transcription factors (Nuclear Factors of Activated T cells)?
answer:
can


question:
Context: The muscular system consists of all the muscles in the body. This is the body system that allows us to move. You also depend on many muscles to keep you alive. Your heart, which is mostly muscle, pumps blood around your body. Each muscle in the body is made up of cells called muscle fibers. Muscle fibers are long, thin cells that can do something that other cells cannot dothey are able to get shorter. Shortening of muscle fibers is called contraction. Muscle fibers can contract because they are made of proteins, called actin and myosin, that form long filaments (or fibers). When muscles contract, these protein filaments slide or glide past one another, shortening the length of the cell. When your muscles relax, the length extends back to the previous position. Nearly all movement in the body is the result of muscle contraction. You can control some muscle movements. However, certain muscle movements happen without you thinking about them. Muscles that are under your conscious control are called voluntary muscles. Muscles that are not under your conscious control are called involuntary muscles. Muscle tissue is one of the four types of tissue found in animals. There are three different types of muscle in the body ( Figure 1.1): 1. Skeletal muscle is made up of voluntary muscles, usually attached to the skeleton. Skeletal muscles move the body. They can also contract involuntarily by reflexes. For example, you can choose to move your arm, but your arm would move automatically if you were to burn your finger on a stove top. This voluntary contraction begins with a thought process. A signal from your brain tells your muscles to contract or relax. Quickly contract and relax the muscles in your fingers a few times. Think about how quickly these signals must travel throughout your body to make this happen. 2. Smooth muscle is composed of involuntary muscles found within the walls of organs and structures such as the esophagus, stomach, intestines, and blood vessels. These muscles push materials like food or blood through organs. Unlike skeletal muscle, smooth muscle can never be under your control. 3. Cardiac muscle is also an involuntary muscle, found only in the heart. The cardiac muscle fibers all contract together, generating enough force to push blood throughout the body. What would happen if this muscle was under conscious or voluntary control? There are three types of muscles in the body: cardiac, skeletal, and smooth. 
 Question: what muscle pushes food through your intestines?
answer:
smooth muscle


question:
Context: Remo Giazotto (September 4, 1910, Rome -- August 26, 1998, Pisa) was an Italian musicologist, music critic, and composer, mostly known through his systematic catalogue of the works of Tomaso Albinoni. 
 Question: The nationality of Remo Giazotto is what?
answer:

italian