TASK DEFINITION: Given scientific fact as input, generate the question from this fact such that it can be answered from the input.
PROBLEM: Pleiotropic effects causes symptoms associated with sickle-cell disease.

SOLUTION: What causes symptoms associated with sickle-cell disease?

PROBLEM: During the early paleozoic, the amount of carbon dioxide in the atmosphere was much greater compared to today.

SOLUTION: During the early paleozoic, the amount of carbon dioxide in the atmosphere compared to today was?

PROBLEM: Centrifuges use inertia to perform their task.

SOLUTION:
Centrifuges use what to perform their task?