instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: Some stem cell lines may contain an endogenous virus or can be contaminated with exogenous viruses (even of animal origin) and may secrete viral particles or express viral antigens on their surface. Moreover, certain biotechnological products (e.g. bovine fetal serum, murine feeder cells) may contain prion particles. Viral and prion contamination of cell cultures and ''feeder'' cells, which is a common risk in all biotechnological products derived from the cell lines, is the most challenging and potentially serious outcome to address, due to the difficulty involved in virus and prion detection and the potential to cause serious disease in recipients of these cell products. Stem cell banks should introduce adequate quality assurance programs like the microbiological control program and can provide researchers with valuable support in the standardization and safety of procedures and protocols used for the viral and prion testing and in validation programs to assure the quality and safety of the cells. 
 Title: Diagnostic approaches for viruses and prions in stem cell banks
answer:
True


question:
Paragraph: Background: Public health emergencies have challenged the public health emergency management systems (PHEMSs) of many countries critically and frequently since this century. As the world's most populated country and the second biggest economy in the world, China used to have a fragile PHEMS; however, the government took forceful actions to build PHEMS after the 2003 SARS outbreak. After more than one decade's efforts, we tried to assess the improvements and problems of China's PHEMS between 2002 and 2012. Methods: We conducted two rounds of national surveys and collected the data of the year 2002 and 2012, including all 32 provincial, 139 municipal, and 489 county CDCs. The municipal and county CDCs were selected by systematic random sampling. Twenty-one indicators of four stages (preparation, readiness, response and recovery) from the National Assessment Criteria for CDC Performance were chosen to assess the ten-year trends. Results: At the preparation stage, organization, mechanisms, workforce, and stockpile across all levels and regions were significantly improved after one decade's efforts. At the readiness stage, the capability for formulating an emergency plan was also significantly improved during the same period. At the response stage, internet-based direct reporting was 98.8%, and coping scores were nearly full points of ten in 2012. At the recovery stage, the capabilities were generally lower than expected. Conclusions: Due to forceful leadership, sounder regulations, and intensive resources, China's PHEMS has been improved at the preparation, readiness, and response stages; however, the recovery stage was still weak and could not meet the requirements of crisis management and preventive governance. In addition, CDCs in the Western region and counties lagged behind in performance on most indicators. Future priorities should include developing the recovery stage, establishing a closed feedback loop, and strengthening the capabilities of CDCs in Western region and counties. 
 Title: The public health emergency management system in China: trends from 2002 to 2012
answer:
True


question:
Paragraph: Beijing, China from 2015 to 2017. Nasopharyngeal swabs and sputum were collected from 30 sentinel hospitals in Beijing and subjected to EV and EV-D68 detection by real-time PCR. The VP1 gene region and complete genome sequences of EV-D68 positive cases were analyzed. Of 21816 ARTI cases, 619 (2.84%) were EV positive and 42 cases were EV-D68 positive. The detection rates of EV-D68 were 0 (0/6644) in 2015, 0.53% (40/7522) in 2016 and 0.03% (2/7650) in 2017, respectively. Two peaks of EV-D68 infections occurred in late summer and early-winter. Ten cases (23.81%) with upper respiratory tract infection and 32 cases (76.19%) presented with pneumonia, including 3 cases with severe pneumonia. The phylogenetic analysis suggested 15 subclade D3 strains and 27 subclade B3 strains of EV-D68 were circulated in China from 2016 to 2017. A total of 52 amino acid polymorphisms were identified between subclades D1 and D3. These data suggest an upsurge of EV-D68 occurred in Beijing in 2016, the new subclade D3 emerged in 2016 and co-circulated with subclade B3 between 2016 and 2017. Enteroviruses (EV) are small, non-enveloped viruses with a single-stranded, positive-sense RNA in the family Picornaviridae 1,2 . The length of enteroviruses is approximately 7.5 kilobases, and divided into 15 species (EV-A to L and rhinovirus A to C) 3-6 . Seven species, including EV-A to D and rhinovirus (RV) A to C, caused a wide spectrum of diseases in human 7,8 . Enterovirus D68 (EV-D68), a member of the species EV-D, was first identified from bronchiolitis and pneumonia in California in 1962 9 . EV-D68 infections have been rarely reported until the worldwide outbreaks 10-18 . A nationwide outbreak of EV-D68 associated with severe respiratory tract infection was reported in the USA from mid-August 2014 to January 15, 2015 and 1,153 cases were confirmed with clinical characteristics of patients mainly resembling pneumonia with severe dyspnea syndrome during this epidemic 19 . In China, sporadic cases of EV-D68 were reported between 2006 and 2014 13,20-23 . The similar results were found that few patients confirmed with EV-D68 infections during the surveillance among US 24 , China 21 in 2015. However, an upsurge of EV-D68 infections occurred in 2016, ranging from Europe to North America, including Netherlands, France, Sweden and United states 24-27 . In addition, sporadic cases have been reported in Hong Kong, Italy, Germany, Portugal and UK in 2016 28, 29 . Earlier phylogenetic analysis revealed that EV-D68 strains circulating worldwide during 1961-2013 were divided into three clades (clades A to C) or lineages (lineages 1 to 3) 10,11,29-31 . With the deepening of the study, the clades of EV-D68 were further refined. After the outbreak of the United States in 2014, EV-D68 was grouped into four clades and five subclades, including clade A, clade B (subclades B1 to B3), clade C and clade D (subclades D1 to D2) 32,33 . The subclade B1 and B3, as the major subclade, circulated around the world in 2014 and in 2016, respectively. To raise awareness of this upsurge of EV-D68 infection, we performed an EV-D68 surveillance study on ARTI cases from the Respiratory Virus Surveillance System (RVSS) in Beijing and analyzed the epidemiological and clinical characteristics of EV-D68 infections from 2015 to 2017 in Beijing. Results A total of 21, 816 ARTI cases were collected from RVSS from January 2015 to December 2017. The median age of them was 36 years old (range: 1 day to 101 years). Among 21, 816 cases, 619 (2.84%) cases were enterovirus positive and 42 (0.19%) cases were EV-D68 positive. 359 cases were successfully amplified among 619 enterovirus positive cases, including 326 cases belonging to EV-A to D, 26 cases and 7 cases belonging to RV-A and RV-C respectively, and no case belonging to RV-B. Of 326 cases belonging to EV-A to D, they were genotyped to 30 serotypes including 9 of EV-A, 16 of EV-B, 4 of EV-C and 1 of EV-D and the dominant serotypes were CVA6, EV-D68, CVA4, CVA2, CVA10, CVA5 and CVA12, accounting for 16.27%, 12.88%, 11.83%, 11.54%, 8.28%, 5.62% and 5.03%, respectively (Fig. 1) . No samples of EV-D68 co-infected with other enteroviruses were found. The annual detection rates of EV-D68 were 0 (0/6, 644) in 2015, 0.53% (40/7, 522) in 2016 and 0.03% (2/7, 650) in 2017, respectively (Table 1) . Twenty cases were aged younger than 18 years, 15 were aged 18 to 60 years and 7 were aged over 60 years. No statistically significant difference of EV-D68 positive rates was identified in the different age groups in 2016 (P = 0.062). Statistical analysis. The differences of EV-D68 positive cases among different age groups were performed using chi-square test. The comparison of EV-D68 different subclades proportions in different age groups were performed using fisher's exact test. The comparison of respiratory diseases by different subclades of EV-D68 were performed using fisher's exact test. A two-sided P value of less than 0.05 was considered to be statistically significant. All analyses were performed using SPSS software, version 17.0. 
 Title: Upsurge of Enterovirus D68 and Circulation of the New Subclade D3 and Subclade B3 in Beijing OPEN
answer:

False