TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Malaria, which is the result of Plasmodium falciparum infection, is a global health threat that resulted in 655,000 deaths and 216 million clinical cases in 2010 alone. Recent phase 3 trials with malaria vaccine candidate RTS,S/AS01 (RTS,S) in children has demonstrated modest efficacy against clinical and severe malaria. RTS,S targets the pre-erythrocytic phase of the disease and induces high antibody titers against the P. falciparum circumsporozoite protein (CSP) and a moderate CD4(+) T cell response. The individual contribution of these adaptive immune responses to protection from infection remains unknown. Here, we found that prophylactic administration of anti-CSP mAbs derived from an RTS,S-vaccinated recipient fully protected mice with humanized livers from i.v.- and mosquito bitedelivered P. falciparum sporozoite challenge. Titers of anti-CSP that conveyed full protection were within the range observed in human RTS,S vaccine recipients. Increasing anti-CSP titers resulted in a dose-dependent reduction of the liver parasite burden. These data indicate that RTS,S-induced antibodies are protective and provide sterilizing immunity against P. falciparum infection when reaching or exceeding a critical plasma concentration.

SOLUTION: RTS S AS01 vaccine was developed to prevent which disease?

PROBLEM: Deletions of the proximal long arm of chromosome 15 (bands 15q11q13) are found in the majority of patients with two distinct genetic disorders, Angelman syndrome (AS) and Prader-Willi syndrome (PWS). The deleted regions in the two syndromes, defined cytogenetically and by using cloned DNA probes, are similar. However, deletions in AS occur on the maternally inherited chromosome 15, and deletions in PWS occur on the paternally derived chromosome 15. This observation has led to the suggestion that one or more genes in this region show differential expression dependent on parental origin (genetic imprinting). No genes of known function have previously been mapped to this region. We show here that the gene encoding the GABAA (gamma-aminobutyric acid) receptor beta 3 subunit maps to the AS/PWS region. Deletion of this gene (GABRB3) was found in AS and PWS patients with interstitial cytogenetic deletions. Evidence of beta 3 gene deletion was also found in an AS patient with an unbalanced 13;15 translocation but not in a PWS patient with an unbalanced 9;15 translocation. The localization of this receptor gene to the AS/PWS region suggests a possible role of the inhibitory neurotransmitter GABA in the pathogenesis of one or both of these syndromes.

SOLUTION: Angelman syndrome is associated with deletion of a part of Chromosome 15 but if the deletion occurs in the paternally inherited chromosome 15, what is the disease?

PROBLEM: In the north of the region is the Sailughem Mountains, also known as Kolyvan Altai, which stretch northeast from 49 N and 86 E towards the western extremity of the Sayan Mountains in 51 60 N and 89 E. Their mean elevation is 1,500 to 1,750 m. The snow-line runs at 2,000 m on the northern side and at 2,400 m on the southern, and above it the rugged peaks tower some 1,000 m higher. Mountain passes across the range are few and difficult, the chief being the Ulan-daban at 2,827 m (2,879 m according to Kozlov), and the Chapchan-daban, at 3,217 m, in the south and north respectively. On the east and southeast this range is flanked by the great plateau of Mongolia, the transition being effected gradually by means of several minor plateaus, such as Ukok plateau (2,380 m) with Pazyryk Valley, Chuya (1,830 m), Kendykty (2,500 m), Kak plateau (2,520 m), (2,590 m), and (2,410 m).

SOLUTION:
Which plateau has the lowest elevation of Ukok, Chuya, and Kak?