Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Q: Context: Mortimer Dormer Leggett (April 19, 1821 -- January 6, 1896) was a lawyer, school administrator, professor, and major general of the Union Army during the American Civil War. 
 Question: Which entity was Mortimer Dormer Leggett a part of?

A: union army
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Q: Context: Edmund Crouchback (16 January 1245 -- 5 June 1296), a member of the House of Plantagenet, was the second surviving son of Henry III of England and Eleanor of Provence. 
 Question: What was the noble family that Edmund Crouchback was from?

A: house of plantagenet
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Q: Context: Biallelic mutations of the DNA annealing helicase SMARCAL1 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1) cause Schimke immuno-osseous dysplasia (SIOD, MIM 242900), an incompletely penetrant autosomal recessive disorder. Using human, Drosophila and mouse models, we show that the proteins encoded by SMARCAL1 orthologs localize to transcriptionally active chromatin and modulate gene expression. We also show that, as found in SIOD patients, deficiency of the SMARCAL1 orthologs alone is insufficient to cause disease in fruit flies and mice, although such deficiency causes modest diffuse alterations in gene expression. Rather, disease manifests when SMARCAL1 deficiency interacts with genetic and environmental factors that further alter gene expression. We conclude that the SMARCAL1 annealing helicase buffers fluctuations in gene expression and that alterations in gene expression contribute to the penetrance of SIOD. 
 Question: Mutations in which gene cause Schimke immune-osseous dysplasia?

A:
harp
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