instruction:
In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".
question:
Paragraph: The spread of the COVID-19 caused by the SARS-CoV-2 outbreak has been growing since its first identification in December 2019. The publishing of the first SARS-CoV-2 genome made a valuable source of data to study the details about its phylogeny, evolution, and interaction with the host. Protein-protein binding assays have confirmed that Angiotensin-converting enzyme 2 (ACE2) is more likely to be the cell receptor via which the virus invades the host cell. In the present work, we provide an insight into the interaction of the viral spike Receptor Binding Domain (RBD) from different coronavirus isolates with host ACE2 protein. By calculating : bioRxiv preprint 2 the binding energy between RBD and ACE2, we highlighted the putative jump in the affinity from a progenitor form of SARS-CoV-2 to the current virus responsible for COVID-19 outbreak. Our result was consistent with the phylogeny analysis and corroborates the opinion that the interface segment of the spike protein RBD might be acquired by SARS-CoV-2 via a complex evolutionary process rather than mutation accumulation. We also highlighted the relevance of Q493 and P499 amino acid residues of SARS-CoV-2 RBD for binding to hACE2 and maintaining the stability of the interface. Moreover, we show from the structural analysis that it is unlikely for the interface residues to be the result of human engineering. Finally, we studied the impact of eight different variants located at the interaction surface of ACE2, on the complex formation with SARS-CoV-2 RBD. We found that none of them is likely to disrupt the interaction with the viral RBD of SARS-CoV-2. 
 Title: Interaction of the spike protein RBD from SARS-CoV-2 with ACE2: similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism
answer:
False


question:
Paragraph: Respiratory virus infection (RVI) in pediatric solid organ transplant (SOT) recipients poses a significant risk; however, the epidemiology and effects of an RVI after pediatric SOT in the era of current molecular diagnostic assays are unclear. Methods. A retrospective observational cohort of pediatric SOT recipients (January 2010 to June 2013) was assembled from 9 US pediatric transplant centers. Charts were reviewed for RVI events associated with hospitalization within 1 year after the transplant. An RVI diagnosis required respiratory symptoms and detection of a virus (ie, human rhinovirus/enterovirus, human metapneumovirus, influenza virus, parainfluenza virus, coronavirus, and/or respiratory syncytial virus). The incidence of RVI was calculated, and the association of baseline SOT factors with subsequent pulmonary complications and death was assessed. Results. Of 1096 pediatric SOT recipients (448 liver, 289 kidney, 251 heart, 66 lung, 42 intestine/multivisceral), 159 (14.5%) developed RVI associated with hospitalization within 12 months after their transplant. RVI occurred at the highest rates in intestine/ abdominal multivisceral (38%), thoracic (heart/lung) (18.6%), and liver (15.6%) transplant recipients and a lower rate in kidney (5.5%) transplant recipients. RVI was associated with younger median age at transplant (1.72 vs 7.89 years; P < .001) and among liver or kidney transplant recipients with the receipt of a deceased-donor graft compared to a living donor (P = .01). The all-cause and attributable case-fatality rates within 3 months of RVI onset were 4% and 0%, respectively. Multivariable logistic regression models revealed that age was independently associated with increased risk for a pulmonary complication (odds ratio, 1.24 [95% confidence interval, 1.02-1.51]) and that receipt of an intestine/multivisceral transplant was associated with increased risk of all-cause death (odds ratio, 24.54 [95% confidence interval, 1.69-327.96]). Conclusions. In this study, hospital-associated RVI was common in the first year after pediatric SOT and associated with younger age at transplant. All-cause death after RVI was rare, and no definitive attributable death occurred. 
 Title: A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection
answer:
True


question:
Paragraph: Neonatal calves possess a very immature and naïve immune system and are reliant on the intake of maternal colostrum for passive transfer of immunoglobulins. Variation in colostrum management of beef and dairy calves is thought to affect early immune development. Therefore, the objective of this study was to examine changes in gene expression and investigate molecular pathways involved in the immune-competence development of neonatal Holstein dairy calves and naturally suckled beef calves using next generation RNA-sequencing during the first week of life. Jugular whole blood samples were collected from Holstein (H) dairy calves (n = 8) artificially fed 5% B.W. colostrum, and from beef calves which were the progenies of Charolais-Limousin (CL; n = 7) and Limousin-Friesian beef suckler cows (LF; n = 7), for subsequent RNA isolation. In dairy calves, there was a surge in pro-inflammatory cytokine gene expression possibly due to the stress of separation from the dam. LF calves exhibited early signs of humoral immune development with observed increases in the expression genes coding for Ig receptors, which was not evident in the other breeds by 7 days of age. Immune and health related DEGs identified as upregulated in beef calves are prospective contender genes for the classification of biomarkers for immune-competence development, and will contribute towards a greater understanding of the development of an immune response in neonatal calves. New-born calves are immunologically naïve at birth, offering the ideal scenario to observe the development of immunocompetence through time. The protection of the womb environment during the pre-partum period, coupled with syndesmochorial placentation, results in a lack of experience to pathogens, meaning that calves are born with an essentially non-functional immune response 1 . Development of immunocompetence in calves relies on successful absorption of maternal colostrum derived immunoglobulins, which in turn is dependent upon successful colostrum management. The importance of colostrum-derived passive immunity, through intestinal absorption of colostral immunoglobulins, to the mortality, morbidity, and subsequent growth and welfare of a newborn calf is recognised internationally 2-5 . Consequently, colostrum feeding management is of critical importance to the health and vitality of the calf, in order to confer protection from the various septicemic and enteric diseases that they are susceptible to in early life 2 . Failure of passive transfer of colostrum derived IgGs (FPT, serum IgG < 10 mg/mL) markedly increases morbidity and mortality in calves 3-5 . There is tremendous variation in the passive immune status of dairy calves 3,6-8 and, generally passive immunity of dairy calves is much lower than beef calves 7 . This difference is primarily attributed to differences in colostrum Ig levels, whereby dairy cows produce relatively large volumes of colostrum with relatively low concentrations of Ig while beef cows produce the opposite 3, 9, 10 . In the suckled beef calf, there are also large differences in passive immunity between cow breed types 3,8 . The use of a systems approach such as RNA sequencing offers advantages over other molecular based techniques such as microarray, enabling unbiased opportunities towards the profiling of developing immunocompetence using a global unbiased view of relative transcriptomic alterations 11 . Peripheral whole blood samples are commonly used for immunological studies as they are easily obtained and may provide an insight into immune development, particularly when combined with a transcriptomics approach 12 . Previous studies from our group Published: xx xx xxxx OPEN www.nature.com/scientificreports/ 2 ScIenTIfIc REPORTS | (2018) 8:15461 | have successfully investigated the immune response of two dairy breeds to gradual weaning using whole blood to analyse alterations in the relative abundance of key immune genes 13 . Here, utilizing the whole blood transcriptome of dairy calves in addition to two beef breeds, we aim to elucidate the molecular mechanisms involved in the development of immunocompetence, from birth through the first 7 days of life. Understanding such mechanisms would be a step towards integrating optimum husbandry practices, and to identifying possible biomarkers associated with development of immunocompetence for breeding of superior calves. 
 Title: Blood immune transcriptome analysis of artificially fed dairy calves and naturally suckled beef calves from birth to 7 days of age OPEN
answer:

True