Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: Chronic myeloid leukemia (CML) is arguably the best understood of all human malignancies. Its origins in the hematopoietic stem cell can be traced to a reciprocal translocation involving chromosomes 9 and 22, dubbed the Philadelphia chromosome, which is observed in essentially all patients. The resulting fusion gene, BCR/ABL, encodes an activated tyrosine kinase that can act alone to induce a CML-like syndrome in mouse models. These animal models have validated BCR/ABL as a target for the development of specific pharmaceutical inhibitors. The kinase inhibitor imatinib mesylate (Gleevec) is highly specific, effective, and minimally toxic, but may not effect cures as a single agent, particularly in patients with accelerated and blast-phase disease. Resistance to imatinib can confound therapy. Surprisingly, a high percentage of resistant cases manifest intact or augmented BCR/ABL signaling, suggesting that this oncoprotein, or signaling pathways emanating from it, remain viable targets. Combination chemotherapy is under active investigation, and among the most compelling strategies is dual treatment with agents that both target BCR/ABL signal transduction. BCR/ABL activates Ras, and compounds designed to antagonize Ras function called farnesyl transferase inhibitors (FTIs) have shown potent activity in vitro and in animal models of BCR/ABL-induced leukemia. Initial clinical trials in patients with refractory acute myeloid leukemia and CML in blast crisis have shown significant activity, suggesting that trials combining imatinib and FTIs are warranted.
Example Output: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

Example Input: Some minerals are very useful. An ore is a rock that contains minerals with useful elements. Aluminum in bauxite ore (Figure 1.1) is extracted from the ground and refined to be used in aluminum foil and many other products. The cost of creating a product from a mineral depends on how abundant the mineral is and how much the extraction and refining processes cost. Environmental damage from these processes is often not figured into a products cost. It is important to use mineral resources wisely. Geologic processes create and concentrate minerals that are valuable natural resources. Geologists study geological formations and then test the physical and chemical properties of soil and rocks to locate possible ores and determine their size and concentration. A mineral deposit will only be mined if it is profitable. A concentration of minerals is only called an ore deposit if it is profitable to mine. There are many ways to mine ores. Aluminum is made from the aluminum- bearing minerals in bauxite. Surface mining allows extraction of ores that are close to Earths surface. Overlying rock is blasted and the rock that contains the valuable minerals is placed in a truck and taken to a refinery. As pictured in Figure 1.2, surface mining includes open-pit mining and mountaintop removal. Other methods of surface mining include strip mining, placer mining, and dredging. Strip mining is like open pit mining but with material removed along a strip. These different forms of surface mining are methods of extracting ores close to Earths surface. Placers are valuable minerals found in stream gravels. Californias nickname, the Golden State, can be traced back to the discovery of placer deposits of gold in 1848. The gold weathered out of hard metamorphic rock in the western Sierra Nevada, which also contains deposits of copper, lead, zinc, silver, chromite, and other valuable minerals. The Underground mining is used to recover ores that are deeper into Earths surface. Miners blast and tunnel into rock to gain access to the ores. How underground mining is approached from above, below, or sideways depends on the placement of the ore body, its depth, the concentration of ore, and the strength of the surrounding rock. Underground mining is very expensive and dangerous. Fresh air and lights must also be brought into the tunnels for the miners, and accidents are far too common. The ores journey to becoming a useable material is only just beginning when the ore leaves the mine (Figure separated out of the ore. A few methods for extracting ore are: heap leaching: the addition of chemicals, such as cyanide or acid, to remove ore. flotation: the addition of a compound that attaches to the valuable mineral and floats. smelting: roasting rock, causing it to segregate into layers so the mineral can be extracted. To extract the metal from the ore, the rock is melted at a temperature greater than 900o C, which requires a lot of energy. Extracting metal from rock is so energy-intensive that if you recycle just 40 aluminum cans, you will save the energy equivalent of one gallon of gasoline.
Example Output: when valuable minerals are taken from stream gravels, this is called

Example Input: Something that is elastic can return to its original shape after being stretched or compressed. This property is called elasticity. As you stretch or compress an elastic material, it resists the change in shape. It exerts a counter force in the opposite direction. This force is called elastic force. Elastic force causes the material to spring back to its original shape as soon as the stretching or compressing force is released. You can watch a demonstration of elastic force at this URL: (3:57). MEDIA Click image to the left or use the URL below. URL: Elastic force can be very useful. You probably use it yourself every day. A few common uses of elastic force are pictured in Figure 13.25. Did you ever use a resistance band like the one in the figure? When you pull on the band, it stretches but doesnt break. The resistance you feel when you pull on it is elastic force. The resistance of the band to stretching is what gives your muscles a workout. After you stop pulling on the band, it returns to its original shape, ready for the next workout. Springs like the ones in Figure 13.26 also have elastic force when they are stretched or compressed. And like stretchy materials, they return to their original shape when the stretching or compressing force is released. Because of these properties, springs are used in scales to measure weight. They also cushion the ride in a car and provide springy support beneath a mattress. Can you think of other uses of springs?
Example Output:
structure that returns to its original shape after being stretched or compressed