Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Ex Input:
Context: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebrovascular disease due to mutations involving loss or gain of a cysteine residue in the NOTCH3 gene. A cluster of mutations around exons 3 and 4 was originally reported. Identification of pathogenic mutation is important for diagnostic confirmation of the disease, however genetic counselling and testing of relatives at risk is critical in mutation carriers. Mutation analysis of the NOTCH3 gene was performed through direct sequencing in 140 patients with clinical suspicion of CADASIL. Patients underwent genetic counselling pre and post testing. The 2-23 exons containing all EGF-like domains were screened. 14 familial forms of the disease have been identified with 14 different causative mutations in exons 2, 3, 4, 5, 7, 10, 14, 19, 20 and 22 of the NOTCH3 gene; no pathogenetic mutations have been identified in exons 6 and 8; several genetic variations both in coding as well as in intronic regions were identified too. Our data confirm the importance of screening the whole EGF-like domains region of NOTCH3 gene for the molecular diagnosis of CADASIL among the Italian population too. Moreover genetic variants different from loss or gain of a cysteine residue are identified and presented. 
 Question: Which amino acid residue appears mutated in most of the cases reported with cadasil syndrome?

Ex Output:
cysteine


Ex Input:
Context: Fluorescence in situ hybridization (FISH) technique has been successfully used to detect the BCR-ABL gene fusion in chronic myeloid leukemia (CML) with the classic form of the Philadelphia chromosome (Ph). We applied FISH to study three CML patients showing variant Ph chromosome (either complex or simple type). The results demonstrate that the use of a yeast artificial chromosome (YAC)-derived probe (D107F9) and a cosmid probe (cos-abl 8), specific for BCR and ABL genes respectively, allows also the detection of the BCR-ABL fusion in CML patients with variant Ph. 
 Question: Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation?

Ex Output:
the bcr/abl gene fusion


Ex Input:
Context: Sometimes, the urinary system ( Figure 1.1) is called the excretory system. But the urinary system is only one part of the excretory system. Recall that the excretory system is also made up of the skin, lungs, and large intestine, as well as the kidneys. The urinary system is the organ system that makes, stores, and gets rid of urine. 1. As you can see above ( Figure 1.1), the kidneys are two bean-shaped organs. Kidneys filter and clean the blood and form urine. They are about the size of your fists and are found near the middle of the back, just below your ribcage. 2. Ureters are tube-shaped and bring urine from the kidneys to the urinary bladder. 3. The urinary bladder is a hollow and muscular organ. It is shaped a little like a balloon. It is the organ that collects urine. 4. Urine leaves the body through the urethra. The kidneys filter the blood that passes through them, and the urinary bladder stores the urine until it is released from the body. Urine is a liquid that is formed by the kidneys when they filter wastes from the blood. Urine contains mostly water, but it also contains salts and nitrogen-containing molecules. The amount of urine released from the body depends on many things. Some of these include the amount of fluid and food a person consumes and how much fluid they have lost from sweating and breathing. Urine ranges from colorless to dark yellow but is usually a pale yellow color. Light yellow urine contains mostly water. The darker the urine, the less water it contains. The urinary system also removes a type of waste called urea from your blood. Urea is a nitrogen-containing molecule that is made when foods containing protein, such as meat, poultry, and certain vegetables, are broken down in the body. Urea and other wastes are carried in the bloodstream to the kidneys, where they are removed and form urine. 
 Question: which organ is not part of the urinary system?

Ex Output:

the ribcage