Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
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Question: Context: Telomeres may regulate human disease by at least two independent mechanisms. First, replicative senescence occurs once short telomeres generate DNA-damage signals that produce a barrier to tumor progression. Second, telomere position effects (TPE) could change gene expression at intermediate telomere lengths in cultured human cells. Here we report that telomere length may contribute to the pathogenesis of facioscapulohumeral muscular dystrophy (FSHD). FSHD is a late-onset disease genetically residing only 25-60 kilobases from the end of chromosome 4q. We used a floxable telomerase to generate isogenic clones with different telomere lengths from affected patients and their unaffected siblings. DUX4, the primary candidate for FSHD pathogenesis, is upregulated over ten-fold in FSHD myoblasts and myotubes with short telomeres, and its expression is inversely proportional to telomere length. FSHD may be the first known human disease in which TPE contributes to age-related phenotype. 
 Question: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?

Answer: fshd


Question: Context: The movie opens with Ralph Wiggum singing along to the 20th Century Fox logo. We then cut to Itchy & Scratchy: The Movie. They are out on the moon. Itchy kills Scratchy and then returns to earth and is painted as a hero by the media. Shortly thereafter, Itchy is elected president. Later as Itchy is in the White House, he sees a supposedly dead Scratchy on the moon. Scratchy holds up a sign that says "I'm telling", which freaks President Itchy out. Itchy then retaliates by sending a hundred missiles toward Scratchy. This is then seen in the theater which is being attended by the Simpsons. Homer stands up and yells "Boring!". Lisa replies "Dad, we can't see the movie!". Homer then goes off on a tirade about why they're paying to watch something in the theater that they normally watch on TV, and that everyone in the audience is a gigantic sucker, especially you. Cue a very fancy and stylized version of the standard Simpsons opening theme.The opening ends with Green Day hosting a concert at Lake Springfield (Singing the Simpsons theme after the opening credits). After they finish their song, they talk about the environment. The audience becomes angry and begins to throw garbage at them polluting the lake and causing their barge to dissolve and sink, killing them. The next day at church, while they have a short memorial for Green Day, Grampa is possessed by God warns the city of a future disaster. Marge believes Grampa's prediction, and decides to work out the meaning of the message. Meanwhile, Lisa starts to talk about the environment, with no success. She encounters Colin, an Irish boy who shares the same passions as her. Homer gets a note from Marge of his chores, and one is fixing the sinkhole. Instead of fixing it, Homer puts Maggie's sandbox over it. His next chore is to fix the roof. While repairing the roof, Homer and Bart decide to have a dare contest. Homer dares Bart to climb the antenna. Bart does so, and gets stuck. Homer shakes it in order to get Bart down. Homer dares Bart to skateboard to Krusty Burger naked, which Bart object's to, saying girls will see his "doodle". After Homer threatens to call him chicken for the rest of his life, Bart agrees. Bart becomes stuck naked on the window of the building. After he is apprehended by the police, and tied to a Stop sign pole, Homer turns up and they decide to order a meal, he brings him socks and a shirt, and no pants. Inside the restuarant, Ned Flanders helps Bart out by giving him a pair of pants, and understands his feelings which begins a relationship and mutual respect between the two. Meanwhile Krusty is filming a commercial. When recording finishes Krusty orders for the pig he is using in the commercial to be slaughtered, causing it to flee to Homer who adopts him, and calls him Spider-Pig. That evening Lisa holds a conference at city hall, called "An Irritating Truth" and explains that the town lake cannot sustain anymore pollution. Mayor Quimby declares a state of emergency and orders the cleansing and protection of Lake Springfield.They put up a fence around the lake to halt further dumping, and announce it is idiot proof, using Cletus as an example to try to throw a possum in the lake, and fail. Soon, Marge asks Homer where "Spider-Pig's/Harry Plopper's" waste is going. Homer shows her an overflowing silo, asking how a pig can fill it up in two days, Homer replies that he helped, horrifying Marge who tells Homer to dispose of it safely. While waiting in a queue at the dump Homer is told by Lenny that Lard Lad Donuts has been shut down and that they are giving away free donuts. Homer, in his haste to get to the giveaway decides on a quicker means of disposal and dumps the silo into the lake, causing it to become heavily polluted. A nearby squirrel jumps into it and becomes severely mutated, with many eyes. Nearby, 
 Question: What do Lisa and Colin convince the entire town to clean?

Answer: the lake


Question: Context: On July 15, 2009 Nucleosys was announced to be disbanding. 
 Question: What year was the end of Nucleosys?

Answer:
2009