TASK DEFINITION: In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
PROBLEM: According to recent statistics, 96 million apparent dengue infections were estimated worldwide in 2010. This figure is by far greater than the WHO prediction which indicates the rapid spread of this disease posing a growing threat to the economy and a major challenge to clinicians and health care services across the globe particularly in the affected areas. This article aims at bringing to light the current epidemiological and clinical status of the dengue fever. The relationship between genetic mutations, single nucleotide polymorphism (SNP) and the pathophysiology of disease progression will be put into perspective. It will also highlight the recent advances in dengue vaccine development. Thus far, a significant progress has been made in unraveling the risk factors and understanding the molecular pathogenesis associated with the disease. However, further insights in molecular features of the disease and the development of animal models will enormously help improving the therapeutic interventions and potentially contribute to finding new preventive measures for population at risk.

SOLUTION: Tackling dengue fever: Current status and challenges

PROBLEM: To ensure the safety of wastewater reuse for irrigation of food crops and drinking water pathogenic viruses must be reduced to levels that pose no significant risk. To achieve this goal minimum reduction of viruses by treatment trains have been suggested. For use of edible crops a 6-log reduction and for production of potable drinking water a 12-log reduction has been suggested. These reductions were based on assuming infective virus concentrations of 10 5 to 10 6 per liter. Recent application of molecular methods suggests that some pathogenic viruses may be occurring in concentrations of 10 7 to 10 9 per liter. Factors influencing these levels include the development of molecular methods for virus detection, emergence of newly recognized viruses, decrease in per capita water use due to conservation measures, and outbreaks. Since neither cell culture nor molecular methods can assess all the potentially infectious virus in wastewater conservative estimates should be used to assess the virus load in untreated wastewater. This review indicates that an additional 2-to 3-log reduction of viruses above current recommendations may be needed to ensure the safety of recycled water. Information is needed on peak loading of viruses. In addition, more virus groups need to be quantified using better methods of virus quantification, including more accurate methods for measuring viral infectivity in order to better quantify risks from viruses in recycled water.

SOLUTION: How much reduction of virus is needed for recycled water: A continuous changing need for assessment?

PROBLEM: Immunity to respiratory virus infection is governed by complex biological networks that influence disease progression and pathogenesis. Systems biology provides an opportunity to explore and understand these multifaceted interactions based on integration and modeling of multiple biological parameters. In this review, we describe new and refined systems-based approaches used to model, identify, and validate novel targets within complex networks following influenza and coronavirus infection. In addition, we propose avenues for extension and expansion that can revolutionize our understanding of infectious disease processes. Together, we hope to provide a window into the unique and expansive opportunity presented by systems biology to understand complex disease processes within the context of infectious diseases. analysis, and model refinement, thus highlighting the iterative cycles intended by systems biology. In this way, the systems biology paradigm drives understanding of complex systems through identification of novel, important components. The approach is not without criticism. Skeptics of systems biology criticize its high cost, slow pace, and descriptive results (2). While these charges reflect the initial development of any new field, the complaints are not at the root of the disillusionment with systems biology. Rather, subscribers of systems biology also over-emphasized the limitations of reductionist science and the corresponding lack of progress in complex diseases treatments for cancer, human immunodeficiency virus (HIV) infection, and diabetes (9). Systems biology was heralded as the evolution and replacement of these approaches, providing novel insights through hypothesis-neutral and discovery based approaches (4). Yet, it has also been fraught with setbacks and challenges, leading to criticisms on its reliance on reductionist-based approaches for validation, lack of hypothesis-driven direction, and declarations that the entire endeavor as a fishing expedition with a limited, non-specific catch (9). This conflict highlights the great irony of systems biology; an approach designed to integrate biological data has successfully divided the scientific field.

SOLUTION:
Bugs in the System