In this task, you are given a context, a subject, a relation, and many options. Based on the context, from the options select the object entity that has the given relation with the subject. Answer with text (not indexes).
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Question: Context: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. The disease may also affect other parts of the body. This may result in a low red blood cell count, inflammation around the lungs, and inflammation around the heart. Fever and low energy may also be present. Often, symptoms come on gradually over weeks to months.
While the cause of rheumatoid arthritis is not clear, it is believed to involve a combination of genetic and environmental factors. The underlying mechanism involves the body's immune system attacking the joints. This results in inflammation and thickening of the joint capsule. It also affects the underlying bone and cartilage. The diagnosis is made mostly on the basis of a person's signs and symptoms. X-rays and laboratory testing may support a diagnosis or exclude other diseases with similar symptoms. Other diseases that may present similarly include systemic lupus erythematosus, psoriatic arthritis, and fibromyalgia among others.
The goal of treatment is to reduce pain, decrease inflammation, and improve a person's overall functioning. This may be helped by balancing rest and exercise, the use of splints and braces, or the use of assistive devices. Pain medications, steroids, and NSAIDs are frequently used to help with symptoms. A group of medications called disease-modifying antirheumatic drugs (DMARDs), such as hydroxychloroquine and methotrexate, may be used to try to slow the progression of disease. Biological DMARDs may be used when disease does not respond to other treatments. However, they may have a greater rate of adverse effects. Surgery to repair, replace, or fuse joints may help in certain situations. Most alternative medicine treatments are not supported by evidence.
RA affects between 0.5 and 1% of adults in the developed world with between 5 and 50 per 100,000 people newly developing the condition each year. Onset is most frequent during middle age and women are affected 2.5 times as frequently as men. In 2013, it resulted in 38,000 deaths up from 28,000 deaths in 1990. The first recognized description of RA was made in 1800 by Dr. Augustin Jacob Landré-Beauvais (17721840) of Paris. The term "rheumatoid arthritis" is based on the Greek for watery and inflamed joints.
Signs and symptoms.
RA primarily affects joints, but it also affects other organs in more than 1525% of individuals., Fibromyalgia (FM) is a medical condition characterised by chronic widespread pain and a heightened pain response to pressure. Other symptoms include feeling tired to a degree that normal activities are affected, sleep problems, and troubles with memory. Some people also report restless legs syndrome, bowel or bladder problems, numbness and tingling, and sensitivity to noise, lights or temperature. Fibromyalgia is frequently associated with depression, anxiety, and posttraumatic stress disorder. Other types of chronic pain are also frequently present.
The cause of fibromyalgia is unknown; however, it is believed to involve a combination of genetic and environmental factors with half the risk attributed to each. The condition runs in families and many genes are believed to be involved. Environmental factors may include psychological stress, trauma, and certain infections. The pain appears to result from processes in the central nervous system and the condition is referred to as a "central sensitization syndrome". Fibromyalgia is recognized as a disorder by the US National Institutes of Health and the American College of Rheumatology. There is no specific diagnostic test. Diagnosis involves first ruling out other potential causes and verifying that a set number of symptoms are present.
The treatment of fibromyalgia can be difficult. Recommendations often include getting enough sleep, exercising regularly, and eating a healthy diet. Cognitive behavioral therapy may also be helpful. The medications duloxetine, milnacipran, or pregabalin may be used. Use of opioid pain medication is controversial with some stating their use is poorly supported by evidence and others saying that weak opioids may be reasonable if other medications are not effective. Dietary supplements also lack evidence to support their use. While fibromyalgia can last a long time, it does not result in death or tissue damage.
Fibromyalgia is estimated to affect 28% of the population. Females are affected about twice as often as males. Rates appear similar in different areas of the world and among different cultures. Fibromyalgia was first defined in 1990 with updated criteria in 2011. There is controversy about the classification, diagnosis, and treatment of fibromyalgia. While some feel the diagnosis of fibromyalgia may negatively affect a person, other research finds it to be beneficial. The term "fibromyalgia" is from New Latin, "fibro-", meaning "fibrous tissues", Greek  "myo-", "muscle", and Greek  "algos", "pain"; thus the term literally means "muscle and fibrous connective tissue pain"., A burn is a type of injury to skin, or other tissues, caused by heat, cold, electricity, chemicals, friction, or radiation. Most burns are due to heat from hot liquids, solids, or fire. Females in many areas of the world have a higher risk related to the more frequent use of open cooking fires or unsafe cook stoves. Alcoholism and smoking are other risk factors. Burns can also occur as a result of self harm or violence between people.
Burns that affect only the superficial skin layers are known as superficial or first-degree burns. They appear red without blisters and pain typically lasts around three days. When the injury extends into some of the underlying skin layer, it is a partial-thickness or second-degree burn. Blisters are frequently present and they are often very painful. Healing can require up to eight weeks and scarring may occur. In a full-thickness or third-degree burn, the injury extends to all layers of the skin. Often there is no pain and the burn area is stiff. Healing typically does not occur on its own. A fourth-degree burn additionally involves injury to deeper tissues, such as muscle, tendons, or bone. The burn is often black and frequently leads to loss of the burned part.
Burns are generally preventable. Treatment depends on the severity of the burn. Superficial burns may be managed with little more than simple pain medication, while major burns may require prolonged treatment in specialized burn centers. Cooling with tap water may help pain and decrease damage; however, prolonged cooling may result in low body temperature. Partial-thickness burns may require cleaning with soap and water, followed by dressings. It is not clear how to manage blisters, but it is probably reasonable to leave them intact if small and drain them if large. Full-thickness burns usually require surgical treatments, such as skin grafting. Extensive burns often require large amounts of intravenous fluid, due to capillary fluid leakage and tissue swelling. The most common complications of burns involve infection. Tetanus toxoid should be given if not up to date.
In 2013, fire and heat resulted in 35 million injuries. This resulted in about 2.9 million hospitalizations and 238,000 dying. Most deaths due to burns occur in the developing world, particularly in Southeast Asia. While large burns can be fatal, treatments developed since 1960 have improved outcomes, especially in children and young adults. In the United States, approximately 96% of those admitted to a burn center survive their injuries. Burns occur at similar frequencies in men and women. The long-term outcome is related to the size of burn and the age of the person affected.
Signs and symptoms.
The characteristics of a burn depend upon its depth. Superficial burns cause pain lasting two or three days, followed by peeling of the skin over the next few days. Individuals suffering from more severe burns may indicate discomfort or complain of feeling pressure rather than pain. Full-thickness burns may be entirely insensitive to light touch or puncture. While superficial burns are typically red in color, severe burns may be pink, white or black. Burns around the mouth or singed hair inside the nose may indicate that burns to the airways have occurred, but these findings are not definitive. More worrisome signs include: shortness of breath, hoarseness, and stridor or wheezing. Itchiness is common during the healing process, occurring in up to 90% of adults and nearly all children. Numbness or tingling may persist for a prolonged period of time after an electrical injury. Burns may also produce emotional and psychological distress., Orthopedic surgery or orthopedics (alternatively spelled orthopaedic surgery and orthopaedics) is the branch of surgery concerned with conditions involving the musculoskeletal system. Orthopedic surgeons use both surgical and nonsurgical means to treat musculoskeletal trauma, spine diseases, sports injuries, degenerative diseases, infections, tumors, and congenital disorders.
Etymology.
Nicholas Andry coined the word ""orthopædics"" in French as "orthopédie", derived from the Greek words  "orthos" ("correct", "straight") and  "paidion" ("child"), when he published "Orthopedie" (translated as "Orthopædia: or the Art of Correcting and Preventing Deformities in Children") in 1741. Though as the name implies it was initially developed with attention to children, the correction of spinal and bony deformities in all stages of life eventually became the cornerstone of orthopedic practice., Septic arthritis, also known as infectious arthritis or joint infection, is the purulent invasion of a joint by an infectious agent which produces arthritis. People with artificial joints are more at risk than the general population but have slightly different symptoms, are infected with different organisms and require different treatment. Septic arthritis is considered a medical emergency. If untreated, it may destroy the joint in a period of days. The infection may also spread to other parts of the body., Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In some types other organs are also affected. Onset can be gradual or sudden.
There are over 100 types of arthritis. The most common forms are osteoarthritis (degenerative joint disease) and rheumatoid arthritis. Osteoarthritis usually occurs with age and affects the fingers, knees, and hips. Rheumatoid arthritis is an autoimmune disorder that often affects the hands and feet. Other types include gout, lupus, fibromyalgia, and septic arthritis. They are all types of rheumatic disease.
Treatment may include resting the joint and alternating between applying ice and heat. Weight loss and exercise may also be useful. Pain medications such as ibuprofen and paracetamol (acetaminophen) may be used. In some a joint replacement may be useful.
Osteoarthritis affects more than 3.8% of people while rheumatoid arthritis affects about 0.24% of people. Gout affects about 1 to 2% of the Western population at some point in their lives. In Australia about 15% of people are affected, while in the United States more than 20% of have a type of arthritis. Overall the disease becomes more common with age. Arthritis is a common reason that people miss work and can result in a decreased quality of life. The term is from Greek "arthro-" meaning joint and "-itis" meaning inflammation., A bone is a rigid organ that constitutes part of the vertebrate skeleton. Bones support and protect the various organs of the body, produce red and white blood cells, store minerals, provide structure and support for the body, and enable mobility. Bones come in a variety of shapes and sizes and have a complex internal and external structure. They are lightweight yet strong and hard, and serve multiple functions. , Pain is a distressing feeling often caused by intense or damaging stimuli, such as stubbing a toe, burning a finger, putting alcohol on a cut, or bumping the "funny bone". Because it is a complex, subjective phenomenon, defining pain has been a challenge. The International Association for the Study of Pain's widely used definition states: "Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage." In medical diagnosis, pain is regarded as a symptom of an underlying condition., A disease is a particular abnormal condition, a disorder of a structure or function, that affects part or all of an organism. The study of disease is called pathology which includes the causal study of etiology. Disease is often construed as a medical condition associated with specific symptoms and signs. It may be caused by external factors such as pathogens, or it may be caused by internal dysfunctions particularly of the immune system such as an immunodeficiency, or a hypersensitivity including allergies and autoimmunity., Replacement arthroplasty (from Greek "arthron", joint, limb, articulate, + "plassein", to form, mould, forge, feign, make an image of), or joint replacement surgery, is a procedure of orthopedic surgery in which an arthritic or dysfunctional joint surface is replaced with an orthopedic prosthesis. Joint replacement is considered as a treatment when severe joint pain or dysfunction is not alleviated by less-invasive therapies. During the latter half of the 20th century, rheumasurgery developed as a subspecialty focused on these and a few other procedures in patients with rheumatic diseases., White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from multipotent cells in the bone marrow known as hematopoietic stem cells. Leukocytes are found throughout the body, including the blood and lymphatic system., Osteoarthritis ( OA ) is a type of joint disease that results from breakdown of joint cartilage and underlying bone . The most common symptoms are joint pain and stiffness . Initially , symptoms may occur only following exercise , but over time may become constant . Other symptoms may include joint swelling , decreased range of motion , and when the back is affected weakness or numbness of the arms and legs . The most commonly involved joints are those near the ends of the fingers , at the base of the thumb , neck , lower back , knees , and hips . Joints on one side of the body are often more affected than those on the other . Usually the problems come on over years . It can affect work and normal daily activities . Unlike other types of arthritis , only the joints are typically affected . Causes include previous joint injury , abnormal joint or limb development , and inherited factors . Risk is greater in those who are overweight , have one leg of a different length , and have jobs that result in high levels of joint stress . Osteoarthritis is believed to be caused by mechanical stress on the joint and low grade inflammatory processes . It develops as cartilage is lost with eventually the underlying bone becoming affected . As pain may make it difficult to exercise , muscle loss may occur . Diagnosis is typically based on signs and symptoms with medical imaging and other tests occasionally used to either support or rule out other problems . Unlike in rheumatoid arthritis , which is primarily an inflammatory condition , the joints do not typically become hot or red . Treatment includes exercise , efforts to decrease joint stress , support groups , and pain medications . Efforts to decrease joint stress include resting and the use of a cane . Weight loss may help in those who are overweight . Pain medications may include paracetamol ( acetaminophen ) . If this does not work NSAIDs such as naproxen may be used , but these medications are associated with greater side effects . Opioids if used are generally only recommended short term due to the risk of addiction . If pain interferes with normal life despite other treatments , joint replacement surgery may help . An artificial joint , however , only lasts a limited amount of time . Outcomes for most people with osteoarthritis are good . OA is the most common form of arthritis with disease of the knee and hip affecting about 3.8 % of people as of 2010 . Among those over 60 years old about 10 % of males and 18 % of females are affected . It is the cause of about 2 % of years lived with disability . In Australia about 1.9 million people are affected , and in the United States about 27 million people are affected . Before 45 years of age it is more common in men , while after 45 years of age it is more common in women . It becomes more common in both sexes as people become older ., Pathology (from the Greek roots of "pathos", meaning "experience" or "suffering", and "-logia", "study of") is a significant component of the causal study of disease and a major field in modern medicine and diagnosis., Medical imaging is the technique and process of creating visual representations of the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organs and tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging., Subject: osteoarthritis, Relation: medical_specialty, Options: (A) infection (B) infectious disease (C) orthopedics (D) pathology (E) rheumatology (F) surgery

Answer: rheumatology


Question: Context: The Professional Football League, formerly the Russian Second Division is the third level of Russian professional football., FC Dynamo Kirov ( Russian :  ``  ''  ) is a Russian association football club from Kirov , founded in 1923 . It plays in the Russian Professional Football League . It played on the professional level in 1937 , 1957 to 1994 , and since 1999 . The highest level it ever achieved was the second highest ( Soviet First League and Russian First Division ) , where it played in 1957 - 1962 , 1982 , 1983 , and 1992 . It was called Dynamo Vyatka ( 1923 - 1934 before the city of Vyatka was renamed to Kirov ) , Vyatka Kirov ( 1993 -- 1996 ) , Mashinostroitel Kirov ( 1997 -- 1998 ) , and Dynamo - Mashinostroitel Kirov ( 1999 -- 2003 ) ., The Soviet First League was the second highest division of Soviet football, below the Soviet Top League. The division lasted from the inception of Soviet league football in 1936 to the dissolution of the USSR in 1991., Subject: fc dynamo kirov, Relation: league, Options: (A) first league (B) football league (C) russian second division

Answer: russian second division


Question: Context: Boricua College is a post-secondary educational institution located in New York City in the United States. The college was designed to serve the educational needs of Puerto Ricans and other Hispanics and was founded by Victor G. Alicea and several others., Scotland (Scots: ) is a country that is part of the United Kingdom and covers the northern third of the island of Great Britain. It shares a border with England to the south, and is otherwise surrounded by the Atlantic Ocean, with the North Sea to the east and the North Channel and Irish Sea to the south-west. In addition to the mainland, the country is made up of more than 790 islands, including the Northern Isles and the Hebrides., The American Academy of Arts and Letters is a 250-member honor society; its goal is to "foster, assist, and sustain excellence" in American literature, music, and art. Located in the Washington Heights neighborhood of Manhattan, New York City, it shares Audubon Terrace, a complex on Broadway between West 155th and 156th Streets, with the Hispanic Society of America and Boricua College., Manhattan is the most densely populated borough of New York City, its economic and administrative center, and the city's historical birthplace. The borough is coextensive with New York County, founded on November 1, 1683, as one of the original counties of the U.S. state of New York. The borough consists mostly of Manhattan Island, bounded by the East, Hudson, and Harlem rivers, and also includes several small adjacent islands and Marble Hill, a small neighborhood on the U.S. mainland., England is a country that is part of the United Kingdom. It shares land borders with Scotland to the north and Wales to the west. The Irish Sea lies northwest of England and the Celtic Sea lies to the southwest. England is separated from continental Europe by the North Sea to the east and the English Channel to the south. The country covers five-eighths of the island of Great Britain (which lies in the North Atlantic) in its centre and south; and includes over 100 smaller islands such as the Isles of Scilly, and the Isle of Wight., Audubon Terrace, also known as the Audubon Terrace Historic District, is a landmark complex of eight early-20th century Beaux Arts/American Renaissance buildings located on the west side of Broadway, bounded by West 155th and West 156th Streets, in the Washington Heights neighborhood of upper Manhattan, New York City. Home to several cultural institutions, the architecturally complementary buildings, which take up most of a city block, are arranged in two parallel rows facing each other across a common plaza. The complex is directly across 155th Street from Trinity Church Cemetery., A research university is a university that expects all its tenured and tenure-track faculty to continuously engage in research, as opposed to merely requiring it as a condition of an initial appointment or tenure. Such universities can be recognized by their strong focus on innovative research and the prestige of their brand names. On the one hand, research universities strive to recruit faculty who are the most brilliant minds in their disciplines in the world, and their students enjoy the opportunity to learn from such experts. On the other hand, new students are often disappointed to realize their undergraduate courses at research universities are overly academic and fail to provide vocational training with immediate "real world" applications; but many employers value degrees from research universities because they know that such coursework develops fundamental skills like critical thinking. , George Washington Duke (December 18, 1820  May 8, 1905) was an American tobacco industrialist and philanthropist who fought in the American Civil War., The British Empire comprised the dominions, colonies, protectorates, mandates and other territories ruled or administered by the United Kingdom and its predecessor states. It originated with the overseas possessions and trading posts established by England between the late 16th and early 18th centuries. At its height, it was the largest empire in history and, for over a century, was the foremost global power. By 1913, the British Empire held sway over 412 million people, % of the world population at the time, and by 1920, it covered , % of the Earth's total land area. As a result, its political, legal, linguistic and cultural legacy is widespread. At the peak of its power, the phrase "the empire on which the sun never sets" was often used to describe the British Empire, because its expanse around the globe meant that the sun was always shining on at least one of its territories., Durham is a city in the U.S. state of North Carolina. It is the county seat of Durham County, though portions also extend into Wake County in the east and Orange County in the west., The City of New York, often called New York City or simply New York, is the most populous city in the United States. With an estimated 2015 population of 8,550,405 distributed over a land area of just , New York City is also the most densely populated major city in the United States. Located at the southern tip of the state of New York, the city is the center of the New York metropolitan area, one of the most populous urban agglomerations in the world. A global power city, New York City exerts a significant impact upon commerce, finance, media, art, fashion, research, technology, education, and entertainment, its fast pace defining the term "New York minute". Home to the headquarters of the United Nations, New York is an important center for international diplomacy and has been described as the cultural and financial capital of the world., James Buchanan Duke (December 23, 1856  October 10, 1925) was a U.S. tobacco and electric power industrialist best known for the introduction of modern cigarette manufacture and marketing, and his involvement with Duke University., Ireland (Ulster-Scots: ) is an island in the North Atlantic. It is separated from Great Britain to its east by the North Channel, the Irish Sea, and St George's Channel. Ireland is the second-largest island of the British Isles, the third-largest in Europe, and the twentieth-largest on Earth., Duke University is a private research university located in Durham, North Carolina, United States. Founded by Methodists and Quakers in the present-day town of Trinity in 1838, the school moved to Durham in 1892. In 1924, tobacco and electric power industrialist James Buchanan Duke established The Duke Endowment, at which time the institution changed its name to honor his deceased father, Washington Duke., Reynolds Price ( February 1 , 1933 -- January 20 , 2011 ) , born Edward Reynolds Price , was an American poet , novelist , dramatist , essayist and James B. Duke Professor of English at Duke University . Apart from English literature , Price had a lifelong interest in Biblical scholarship . He was a member of the American Academy of Arts and Letters ., This article is focused on English-language literature rather than the literature of England, so that it includes writers from Scotland, Wales, and the whole of Ireland, as well as literature in English from countries of the former British Empire, including the United States. However, until the early 19th century, it only deals with the literature of the United Kingdom and Ireland. It does not include literature written in the other languages of Britain., The Hispanic Society of America is a museum and reference library for the study of the arts and cultures of Spain, Portugal, and Latin America. (Despite the name and the founder's intention, it has never functioned as a learned association.) Founded in 1904 by Archer M. Huntington, the institution is free and open to the public at its original location in a Beaux Arts building on Audubon Terrace (at 155th Street and Broadway) in the lower Washington Heights area of New York City in the United States. The campus was designated a National Historic Landmark in 2012., Wales is a country that is part of the United Kingdom and the island of Great Britain. It is bordered by England to the east, the Irish Sea to the north and west, and the Bristol Channel to the south. It had a population in 2011 of 3,063,456 and has a total area of . Wales has over of coastline and is largely mountainous, with its higher peaks in the north and central areas, including Snowdon, its highest summit. The country lies within the north temperate zone and has a changeable, maritime climate., The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a sovereign country in western Europe. Lying off the north-western coast of the European mainland, it includes the island of Great Britain (the name of which is also loosely applied to the whole country), the north-eastern part of the island of Ireland, and many smaller islands. Northern Ireland is the only part of the UK that shares a land border with another sovereign statethe Republic of Ireland. Apart from this land border, the UK is surrounded by the Atlantic Ocean, with the North Sea to its east, the English Channel to its south and the Celtic Sea to its south-south-west, giving it the 12th-longest coastline in the world. The Irish Sea lies between Great Britain and Ireland. With an area of , the UK is the 78th-largest sovereign state in the world and the 11th-largest in Europe. It is also the 21st-most populous country, with an estimated 65.1 million inhabitants. Together, this makes it the fourth most densely populated country in the European Union., The Duke Endowment is a private foundation established in 1924 by industrialist and philanthropist James B. Duke. The mission of the foundation is to serve the people of North Carolina and South Carolina by supporting selected programs of higher education, health care, children's welfare, and spiritual life., Subject: reynolds price, Relation: place_of_death, Options: (A) atlantic ocean (B) best (C) durham (D) england (E) english channel (F) george (G) hudson (H) huntington (I) ireland (J) isle (K) isles of scilly (L) manhattan (M) media (N) mission (O) most (P) new york (Q) north atlantic (R) north carolina (S) north channel (T) northern ireland (U) orange county (V) portugal (W) scotland (X) side (Y) snowdon (Z) south carolina ([) spain (\) trinity (]) union (^) united kingdom (_) wales (`) washington (a) york (b) york county

Answer:
durham