TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: A significant role for IFN in the pathogenesis of systemic lupus erythematosus is well supported, and clinical trials of anti-IFN monoclonal antibodies are in progress in this disease. In other autoimmune diseases characterized by substantial inflammation and tissue destruction, the role of type I interferons is less clear. Gene expression analysis of peripheral blood cells from patients with rheumatoid arthritis and multiple sclerosis demonstrate an interferon signature similar to but less intense than that seen in patients with lupus. In both of those diseases, presence of the interferon signature has been associated with more significant clinical manifestations. At the same time, evidence supports an anti-inflammatory and beneficial role of IFN locally in the joints of patients with rheumatoid arthritis and in murine arthritis models, and many patients with multiple sclerosis show a clinical response to recombinant IFN. As can also be proposed for type I diabetes mellitus, type I interferon appears to contribute to the development of autoimmunity and disease progression in multiple autoimmune diseases, while maintaining some capacity to control established disease - particularly at local sites of inflammation. Recent studies in both rheumatoid arthritis and multiple sclerosis suggest that quantification of type I interferon activity or target gene expression might be informative in predicting responses to distinct classes of therapeutic agents.

SOLUTION: Which is the most common gene signature in Rheumatoid Arthritis patients?

PROBLEM: The film opens where the previous film ended, set a few years later, where Rafiki (Robert Guillaume) gathers the animals of the Pride Lands together for the presentation of Simba (Matthew Broderick) and Nalas (Moira Kelly) new daughter Kiara. Mufasa's spirit (James Earl Jones) watches over the ceremony. Later, Simba becomes very overprotective of an older Kiara (Michelle Horn), assigning Timon and Pumbaa (Nathan Lane and Ernie Sabella) to watch her. One day as Kiara was playing, she fell into a small pond as Timon and Pumbba got her back onto land. Kiara tells them only half of her is a princess. Pumbba asks, "Well, who's the other half?" While they wait for her to answer, they start having a snack. Then they started arguing about slimy and crunchy grubs. While they were arguing, Kiara sneaks into the "Outlands" where she meets a young cub named Kovu (Ryan O'Donohue). After escaping a river filled with nile crocodiles, the two become friendly, unaware they are being watched by Kovu's mother, Zira (Suzanne Pleshette). Simba arrives and confronts Zira, who reminds Simba that he exiled the Outsiders, and that if he wants to punish them, Kovu is Scar's hand-chosen successor. Unwilling to harm the cub, Simba orders them to leave. Later Simba scolds Kiara for endangering herself. In the Outlands, Zira's eldest son, Nuka (Andy Dick), complains to his younger sister Vitani (Lacey Chabert) about Kovu's status as "the Chosen One" the cub chosen by Scar to lead the pride after his death. ("I should've been the "Chosen One". I'm the strongest, I'm the smartest, I'm the oldest, etc.") At that moment, Zira returns and scolds both of her sons, but Kovu accidentally gives her the idea to use Kovu's new friendship with Kiara as a means of exacting her revenge on Simba for Scar's death. Now an adult, Kiara (Neve Campbell) heads out from home for her first solo hunt, however Simba again sends Timon and Pumbaa to follow and watch her progress after he promised to let Kiara hunt on her own. Furious to find out her father still insists on maintaining surveillance, Kiara goes further from home to hunt, though is still unsuccessful in her efforts. Meanwhile, Zira's plan to implant Kovu in Simba's pride has been set in motion; Nuka and Vitani (Jennifer Lien) set fire to the plains where Kiara is hunting, causing her to faint and giving Kovu (Jason Marsden) the chance to rescue her. Drawn by the smoke, Simba finds them together and reluctantly accepts Kovu's request to come to Pride Rock in return for saving Kiara's life, though he forces Kovu to sleep outside. That same night, Simba has a nightmare about his father's death, where Scar suddenly morphs into Kovu and Simba takes his father's place falling off the cliff. The next morning, he goes outside to a watering hole where Kovu contemplates attacking him, but Kiara interrupts and they go off together so Kovu can help her learn how to hunt. Kiara kept on failing. During the lesson, Kovu was setting an example for Kiara, thinking Timon was just an ordinary meerkat. They run into Timon and Pumbaa struggling with some birds, so the two lions help them chase the birds off. Together, they have fun playing, something Kovu notes he has never experienced before. That night, Kovu tells Kiara that he is not Scar's real son, but "was a part of him". Simba watches from above, seeking guidance from the "Great Kings" and Nala advises him to give Kovu a chance, because he is not his father. Kovu decides to leave after he almost confesses his real intentions to Kiara, but Rafiki stops him and invites the young lions to experience "Upendi" love. After a musical journey through the jungle, the two fall in love. In the morning, Simba invites Kovu for a walk and tells him the true story of

SOLUTION: Who did Kiara meet at the Outlands?

PROBLEM: 1784 Benguella, provisional designation 1935 MG, is an asteroid from the asteroid belt discovered by English-born South African astronomer Cyril Jackson at Union Observatory, Johannesburg on 30 June 1935.

SOLUTION:
At which time was 1784 Benguella discovered?