In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: Point out the correct answer in relation to the monitoring of plasma drug concentrations: 
 Options:  <1> Allergy reactions are related to the dose administered. <2> The extraction of the blood sample must be done once the balance of drug distribution in the organism has been reached. <3> The information provided by the analytical determination of plasma concentration is sufficient to perform the dosage individualization. <4> Only the immunoassay methods are valid for carrying out the analytical determination of the blood samples. <5> It must be done for all drugs that are administered intravenously.
2

Question: A 45-year-old patient who went to the emergency room for general malaise, headache and progressive tiredness in recent weeks. On physical examination, a slight icteric dye of the skin and mucous membranes was detected and a 2-cm splenomegaly was felt under the costal margin. The analytical presents hemoglobin 8.6 g / dL, VCM 100 fL. The number of reticulocytes is high and anisopoikilocytosis is observed in the blood smear. In the biochemistry highlights LDH 1300 IU / L, bilirubin 2.2 mg / dL and undetectable haptoglobin. Which test is the most appropriate to guide the diagnosis of the patient? 
 Options:  <1> Fecal occult blood test. <2> Test of Coombs. <3> Determination of iron, cobalamin and folic acid. <4> Abdominal ultrasound. <5> Bone marrow aspirate.
2

Question: The bacteria contain endotoxins: 
 Options:  <1> Of all types except microplasmas. <2> Gram positive. <3> Gram negative <4> Intracellular <5> Endospore formers

3