Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: In chronic lymphocytic leukemia (CLL) signals from the B cell receptor (BCR) play a major role in disease development and progression. In this light, new therapies that specifically target signaling molecules downstream of the BCR continue to be developed. While first studies on the selective small molecule inhibitor of Bruton's tyrosine kinase (Btk), Ibrutinib (PCI-32765), demonstrated that Btk inhibition sensitizes CLL cells to apoptosis and alters their migratory behavior, these studies however did not address whether Btk-mediated signaling is involved in the process of CLL leukemogenesis. To investigate the requirement of Btk signaling for CLL development, we modulated Btk expression in the IgH.ET CLL mouse model, which is based on sporadic expression of the simian oncovirus SV40 T-antigen in mature B cells. To this end, we crossed IgH.ET mice on a Btk-deficient background or introduced a human Btk transgene (CD19-hBtk). Here we show that Btk deficiency fully abrogates CLL formation in IgH.ET mice, and that leukemias formed in Btk haplo-insufficient mice selectively expressed the wild-type Btk allele on their active X chromosome. Conversely, Btk overexpression accelerated CLL onset, increased mortality, and was associated with selection of non-stereotypical BCRs into CLL clones. Taken together, these data show that Btk expression represents an absolute prerequisite for CLL development and that Btk mediated signaling enhances leukemogenesis in mice. We therefore conclude that in CLL Btk expression levels set the threshold for malignant transformation.

A: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?
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Q: King Hedley II is a play by American playwright August Wilson, the eighth in his ten-part series, The Pittsburgh Cycle.

A: Who wrote the novel King Hedley II?
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Q: It seems that beauty and women are twins.You are joking? No,I do not.Observe for yourself Ads on fashion TV screens,radio programs,magazines,newspapers,and the streets.Whether they have realized it or not, women are surrounded by a sea of fashion.They are taught to think that without beautiful clothes they will grow old and lose their charm.So who dares to neglect dressing up at the cost of their appearance and youth? But I do not agree with the opinion that women have to show their beauty through their looks.The richness of their minds proves to be more beautiful and attractive than their looks.A woman who has experienced many troubles and may be called "aunt" or "granny" can still keep up her beauty if she has such excellent qualities as knowledge,ability,a kind heart,great courage,concern for others,etc. In addition,old and young,beautiful and ugly are concept.People who keep a young mind will never feel old.Interested in new things and eager to learn more,they keep up with the tide.Plainly dressed women may have a type of beauty that is pure and real.Reading and learning is the best way to keep one youthful.Good books ale rich soil which can feed the flower of one's heart and looks.

A:
What is the best way for a woman to appear young according to the writer?
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