Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
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Question: Context: Dabigatran is a direct thrombin inhibitor used to reduce the risk of stroke in patients with nonvalvular atrial fibrillation. For patients who present with an acute stroke despite dabigatran therapy, clinical data on the use of intravenous tissue plasminogen activator (IV-tPA) is limited. There is an anticipated increased risk of symptomatic intracranial hemorrhage (sICH) when using IV-tPA in patients on dabigatran therapy. In 2015, the humanized monoclonal antibody fragment idarucizumab was approved for rapid (minutes) reversal of anticoagulant effects of dabigatran. Dabigatran reversal with idarucizumab before administration of IV-tPA might reduce the risk of sICH. We report a case of a 69-year-old stroke patient on dabigatran for paroxysmal atrial fibrillation who presented with an initial National Institutes of Health Stroke Scale (NIHSS) of 12. There was no early evidence of ischemic stroke or hemorrhage on head computed tomography, and coagulation studies implied therapeutic dabigatran levels. After controlling blood pressure, dabigatran was reversed with idarucizumab, and IV-tPA was administrated beginning 197minutes after he was last seen at his baseline. Subsequent brain magnetic resonance imaging showed 2 punctate infarcts in the left temporal lobe and occipital lobe with no evidence of hemorrhage. The patient was discharged with an NIHSS of 1. Telephone follow-up 2 months later indicated that he was at his prestroke baseline, except for a complaint of worsened short-term memory. Idarucizumab reversal of dabigatran may reduce the risk of sICH and should be considered for acute stroke patients arriving in the IV-tPA time window. 
 Question: Which drug can be reversed with idarucizumab?

Answer: dabigatran


Question: Context: Chronic lymphocytic leukemia (CLL) cells depend on microenvironmental factors for proliferation and survival. In particular, the B-cell receptor (BCR) and nuclear factor- B (NF-B) pathways are activated in the lymph node (LN) microenvironment. Thus, model systems mimicking tumor-host interactions are important tools to study CLL biology and pathogenesis. We investigated whether the recently established NOD/scid/c(null) (NSG) mouse xenograft model can recapitulate the effects of the human microenvironment. We assessed, therefore, tumor characteristics previously defined in LN-resident CLL cells, including proliferation, and activation of the BCR and NF-B pathways. We found that the murine spleen (SP) microenvironment supported CLL cell proliferation and activation to a similar degree than the human LN, including induction of BCR and NF-B signaling in the xenografted cells. Next, we used this model to study ibrutinib, a Bruton's tyrosine kinase inhibitor in clinical development. Ibrutinib inhibited BCR and NF-B signaling induced by the microenvironment, decreased proliferation, induced apoptosis and reduced the tumor burden in vivo. Thus, our data demonstrate that the SP of xenografted NSG mice can, in part, recapitulate the role of the human LN for CLL cells. In addition, we show that ibrutinib effectively disrupts tumor-host interactions essential for CLL cell proliferation and survival in vivo. 
 Question: What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?

Answer: ibrutinib


Question: Context: Newtons third law of motion states that every action has an equal and opposite reaction. This means that forces always act in pairs. First an action occurs, such as the skateboarders pushing together. Then a reaction occurs that is equal in strength to the action but in the opposite direction. In the case of the skateboarders, they move apart, and the distance they move depends on how hard they first pushed together. You can see other examples of actions and reactions in Figure 14.9. You can watch a video about actions and reactions at this URL: You might think that actions and reactions would cancel each other out like balanced forces do. Balanced forces, which are also equal and opposite, cancel each other out because they act on the same object. Action and reaction forces, in contrast, act on different objects, so they dont cancel each other out and, in fact, often result in motion. For example, in Figure 14.9, the kangaroos action acts on the ground, but the grounds reaction acts on the kangaroo. As a result, the kangaroo jumps away from the ground. One of the action-reaction examples in the Figure 14.9 does not result in motion. Do you know which one it is? What if a friend asked you to play catch with a bowling ball, like the one pictured in Figure 14.10? Hopefully, you would refuse to play! A bowling ball would be too heavy to catch without risk of injury assuming you could even throw it. Thats because a bowling ball has a lot of mass. This gives it a great deal of momentum. Momentum is a property of a moving object that makes the object hard to stop. It equals the objects mass times its velocity. It can be represented by the equation: Momentum = Mass Velocity This equation shows that momentum is directly related to both mass and velocity. An object has greater momentum if it has greater mass, greater velocity, or both. For example, a bowling ball has greater momentum than a softball when both are moving at the same velocity because the bowling ball has greater mass. However, a softball moving at a very high velocity say, 100 miles an hour would have greater momentum than a slow-rolling bowling ball. If an object isnt moving at all, it has no momentum. Thats because its velocity is zero, and zero times anything is zero. Momentum can be calculated by multiplying an objects mass in kilograms (kg) by its velocity in meters per second (m/s). For example, assume that a golf ball has a mass of 0.05 kg. If the ball is traveling at a velocity of 50 m/s, its momentum is: Momentum = 0.05 kg 50 m/s = 2.5 kg m/s Note that the SI unit for momentum is kgm/s. Problem Solving Problem: What is the momentum of a 40-kg child who is running straight ahead with a velocity of 2 m/s? Solution: The child has momentum of: 40 kg 2 m/s = 80 kgm/s. You Try It! Problem: Which football player has greater momentum? Player A: mass = 60 kg; velocity = 2.5 m/s Player B: mass = 65 kg; velocity = 2.0 m/s When an action and reaction occur, momentum is transferred from one object to the other. However, the com- bined momentum of the objects remains the same. In other words, momentum is conserved. This is the law of conservation of momentum. Consider the example of a truck colliding with a car, which is illustrated in Figure 14.11. Both vehicles are moving in the same direction before and after the collision, but the truck is moving faster than the car before the collision occurs. During the collision, the truck transfers some of its momentum to the car. After the collision, the truck is moving slower and the car is moving faster than before the collision occurred. Nonetheless, their combined momentum is the same both before and after the collision. You can see an animation showing how momentum is conserved in a head- 
 Question: property of a moving object that makes it hard to stop

Answer:
momentum