In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

[EX Q]: Question: With what aspect does the difficulty of the elderly relate to solve new problems ?: 
 Options:  <1> Creativity. <2> Motivation. <3> Verbal fluency. <4> Memory. <5> Response time.
[EX A]: 5

[EX Q]: Question: Indinavir is a selective inhibitor of HIV protease because: 
 Options:  <1> By hydrolysis, the active drug is generated. <2> Rents irreversibly the active center of the enzyme. <3> Its structure mimics the transition state of the reaction catalyzed by the enzyme. <4> It is a suicide inhibitor. <5> Its symmetric structure interacts effectively with the active center of the enzyme.
[EX A]: 3

[EX Q]: Question: Indicate which of the following is an alteration of the pyrimidine metabolism: 
 Options:  <1> Thrombophilia <2> Phenylketonuria <3> Wilson's disease <4> Urine disease with the smell of maple syrup. <5> Orotic hereditary acidity.
[EX A]:
5