In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Input: Consider Input: Paragraph: There is a need for simple and inexpensive diagnostic and screening tests for the detection of Cryptosporidium parvum infection in calves. A sucrose wet mount test and a lateral immunochromatography test were evaluated for epidemiological sensitivity and specificity, cost per test, simplicity, test time and ease of batching. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) of the Cryptosporidium oocyst wall protein (COWP) gene locus, with gel electrophoresis, was used as a gold standard. Cohen's kappa statistic of agreement (k) between the Ontario Veterinary College (OVC) sucrose wet mount test and COWP PCR-RFLP was 0.82, and the sensitivity and specificity of the OVC sucrose wet mount test were 88.6% and 93.8%, respectively. The sensitivity and specificity of the lateral immunochromatography test were 78.3% and 93.3%, respectively, and agreement between this test and PCR-RFLP was good (k = 0.73). There was substantial agreement between the OVC sucrose wet mount test and the lateral immunochromatography test (k = 0.84). Both tests were inexpensive and easy to use; however, the lateral immunochromatography test was faster and simpler to perform than the sucrose wet mount test, and was generally more user-friendly. These tests provide practitioners and researchers with cheap, quick and accurate methods of detecting C. parvum infection in young calves. # 
 Title: Multiattribute evaluation of two simple tests for the detection of Cryptosporidium parvum in calf faeces

Output: False


Input: Consider Input: Paragraph: Saffold virus (SAFV) is classified into the Cardiovirus genus of the Picornaviridae family. Up to now, eleven genotypes have been identified however, their clinical significance remains unclear. Here, we investigated the presence of SAFV in asymptomatic patients admitted for adenoidectomy. A total of 70 adenoid tissue samples were collected from children with clinical symptoms caused by hypertrophy of adenoids but without symptoms of airway infection. Samples were investigated for SAFV by RT-nested PCR and sequence analysis. Eleven of 70 (15.7%) samples were positive for SAFV. Nasopharyngeal swabs were available from 45 children just before surgery. SAFV was rarely found and only in children with SAFV-positive adenoids 2/8. Our findings indicate that the presence of SAFV seems to be more frequent in adenoid tissue than expected. This could support the notion of a longer than previously anticipated persistence of SAFV nucleic acids in the respiratory tract and possibly a chronic infection. Further investigations are necessary to establish the role of SAFV infection in humans. 
 Title: Frequent detection of Saffold cardiovirus in adenoids

Output: True


Input: Consider Input: Paragraph: a b c d MERS-CoV NP Podocin Merge 50 µm Supplementary figure 1. Productive MERS-CoV replication in a primary human podocyte cell line. (a) Co-immunohistochemical staining of MERS-CoV NP (green) and a podocytespecific marker, podocin (red) in a primary human podocyte cell line 1 24 h after the challenge of MERS-CoV. (b) Western blot analysis of MERS-CoV NP in MERS-CoV-and mock-infected podocytes. γ-tubulin was also detected as a loading control. Total RNAs (c) and the conditioned media (d) of the MERS-CoV-inoculated podocytes were harvested for viral load detection at the indicated time-points using RT-qPCR as previously described. 2 The MERS-CoV RNA from the cell lysates were normalized to the expression level of GAPDH mRNA. Images shown in a and b are representatives of three independent experiments. Error bars shown in c and d represent the mean ± s.d. of three independent experiments. Statistical significance was evaluated by Student's t-tests and the ranges of p-values were indicated in c and d. Samples from a, b, c and d represent biological replicates. NATURE MICROBIOLOGY | www.nature.com/naturemicrobiology 1 2 50 µm 50 µm Supplementary figure 2. Apoptosis due to MERS-CoV infection in kidney cells or overexpression of Smad7 and FGF2 in uninfected kidney cells. (a) HK2 cells were infected by MERS-CoV or SARS-CoV at M.O.I. = 9.6, separately. At different time-points (0, 16, 28 and 34 hpi), the infected cells were assayed by terminal deoxynucleotidy transferase dUTP nick end labeling (TUNEL) assays. The degree of apoptosis (top) was measured by counting the number of positively stained cells (red focal stain; bottom) over the total number of cells in the counted fields (blue nuclei counterstained by DAPI; bottom). Statistical analyses of the percentage of apoptotic cells induced by MERS-CoV over that of SARS-CoV were evaluated by Student's ttests and the ranges of p-values were indicated on top of each time-point. Immunostainings of the virus NP (green; bottom) in each infection condition were included. (b) HK2 cells were transfected with overexpression constructs of Smad7 and FGF2 followed by the detection of apoptosis using TUNEL assays as described above. Different doses of cDNA (0, 0.25 and 0.5 μg) were first topped up to 0.5 μg with their vector backbone plasmids followed by transfection. The degree of apoptosis (top) was measured by counting the number of positively stained cells (red focal stain; bottom) over the total number of cells in the counted fields (blue nuclei counterstained by DAPI; bottom). Images shown in a and b are representatives of three independent experiments. Error bars shown in a and b represent the mean ± s.d. of three independent experiments. Statistical significance was evaluated by Student's t-tests and the ranges of p-values were indicated in a and b. Samples from a and b represent biological replicates. NATURE MICROBIOLOGY | www.nature.com/naturemicrobiology 
 Title: MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2


Output: False