TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Is a gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity associated with familial Inappropriate Sinus Tachycardia?
Answer: This is the first report of a gain-of-function HCN4 mutation associated with IST through increased sensitivity to cAMP-dependent activation.

SOLUTION: yes

PROBLEM: Question: Do high-oxygen-transmissibility soft contact lenses induce limbal hyperaemia?
Answer: SCL wear induces a marked increase in limbal hyperaemia during open-eye wear, which is not seen either in the no lens situation or when EHD lenses are worn. The pattern of limbal hyperaemia for both the open and closed eyes during EHD lens wear is very similar to that for the no-lens situation. The mechanism whereby SCL induces excess limbal hyperaemia has not been absolutely established, but it may involve local hypoxia.

SOLUTION: no

PROBLEM: Question: Does mitral regurgitation reduce systemic coagulation activity in patients with rheumatic heart disease?
Answer: Plasma D-dimer levels correlated with the embolic risk in mitral valve disease and non-valvular AF. The highest levels were found in patients with MS+AF and non-valvular AF. Severe MR decreased the D-dimer levels in MS and/or AF to control levels.

SOLUTION:
yes