Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. Despite significant progresses in the last decades, the origin of this cancer remains unclear and no efficient therapy exists. PDAC does not arise de novo: three remarkable different types of pancreatic lesions can evolve towards pancreatic cancer. These precursor lesions include: Pancreatic intraepithelial neoplasia (PanIN) that are microscopic lesions of the pancreas, Intraductal Papillary Mucinous Neoplasms (IPMN) and Mucinous Cystic Neoplasms (MCN) that are both macroscopic lesions. However, the cellular origin of these lesions is still a matter of debate. Classically, neoplasm initiation or progression is driven by several genetic and epigenetic alterations. The aim of this review is to assemble the current information on genetic mutations and epigenetic disorders that affect genes during pancreatic carcinogenesis. We will further discuss the interest of the genetic and epigenetic alterations for the diagnosis and prognosis of PDAC. Large genetic alterations (chromosomal deletion/amplification) and single point mutations are well described for carcinogenesis inducers. Mutations classically occur within key regions of the genome. Consequences are various and include activation of mitogenic pathways or silencing of apoptotic processes. Alterations of K-RAS, P16 and DPC4 genes are frequently observed in PDAC samples and have been described to arise gradually during carcinogenesis. DNA methylation is an epigenetic process involved in imprinting and X chromosome inactivation. Alteration of DNA methylation patterns leads to deregulation of gene expression, in the absence of mutation. Both genetic and epigenetic events influence genes and non-coding RNA expression, with dramatic effects on proliferation, survival and invasion. Besides improvement in our fundamental understanding of PDAC development, highlighting the molecular alterations that occur in pancreatic carcinogenesis could provide new clinical tools for early diagnosis of PDAC and the molecular basis for the development of new effective therapies.

A: Which is the molecular mechanism underlying K-ras alterations in carcinomas?
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Q: German academics believe they have solved the centuries-old mystery of the "Mona Lisa" in Leonardo ad Vinci's famous portrait . Lisa Gherardini, the wife of a wealthy Florentine merchant, Francesco del Giocondo, has long been seen as the most likely model for the sixteenth-century painting. Art historians have wondered whether the smiling woman may actually have been da Vinci's lover or mother, or the artist himself. Now experts at the prefix = st1 /HeidelbergUniversitylibrary say old notes made in a book by its owner in October, 1503, confirm that Lisa del Giocondo was indeed the model for the famous portrait in the world. "All doubts about the identity of the Mona Lisa have been removed by a discovery by Dr. Armin Schlechter," the library said in a statement on Monday. "Until then, only 'scant evidence' from sixteenth-century documents had been available. These had left lots of room for doubt, and many different identities were put forward." The comments compare Leonardo to the ancient Greek artist Apelles, and say he was working on three paintings at that time, one of which was a portrait of Lisa del Giocondo. Art experts say the Heidelbergdiscovery is a break-through, and the earliest mention linking the merchant's wife to the portrait. Before this discovery the earliest link dated from around 1550, and was made by Italian official Giorgio Vasari, the library said, adding that there had been doubts about Vasari's reliability. The Heidelbergnotes were actually discovered over two year's ago in the library by Schlechter, a spokeswoman said. Although the findings were published in the library's catalogue, they were not widely publicized, and received little attention until a German broadcaster decided to do some recording there, she said.

A: Who discovered the Heidelbergnotes?
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Q: The Bat has struck again, making off with a priceless necklace even after warning the police that he would rob the safe at precisely 1 a.m., after which he intends to go to country in order to give the police a rest. On his way through the village of Oakdale, the Bat notices someone robbing the Oakdale bank. Intrigued, the Bat follows the robber, who leads him to the old Fleming mansion.Inside the Fleming mansion, Cornelia van Gorder [Grayce Hamptom] and her ditzy maid Lizzie Allen [Maude Eburne] are discussing Cornelia's decision to rent the house for the summer. The big old house is a scary place, and Lizzie doesn't like the strange sounds, the strange caretaker [Spencer Charters], and the strange stories he tells about seeing ghosts in the house. Add to the fact that the Bat has taken to the country, and Lizzie is terrified of everything and anything. She's even gone so far as to set a bear trap outside her bedroom window, just in case the Bat decides to pay a vist. When Cornelia's niece Dale [Una Merkel], who works at the Oakdale Bank, returns home with her boyfriend Brook Bailey[William Bakewell] and tries to pass him off as a gardener, Cornelia is immediately suspicious (Cornelia: Any experience with alopecias? Brook: They dry up if you don't water them.), but Cornelia hires him anyway, at least until she can find out why Dale has brought him home.A rock suddenly comes crashing through the window. A note on it reads: Get out of the house now while there is still time. Immediately thereafter, Dr Venrees [Gustav von Seyffertitz] drops by to inform Cornelia that the Oakdale bank has been robbed of a half million dollars and that Fleming, Sr, the owner of the mansion, is returning from Europe so Cornelia will have to vacate the house. Then, a heavy painting moves, and a voice from behind warns them to get out of the house. Becoming concerned, Cornelia phones the police. When Detective Anderson [Chester Morris] shows up, Cornelia explains her suspicion that Fleming, Jr [Hugh Huntley] is trying to frighten her out of the house, possibly because he rented it to her while his father was out of the country. Nowthat his father is returning, she thinks he may be trying to frighten her into leaving.Soon everyone begins acting suspiciously. The doctor unlocks the broken window and "forgets" to relock it until Cornelia relocks it herself. Alone in the parlor for a few moments, Venrees unlocks the window again. Brook starts going around the house pounding on the walls. Dale phones Fleming Jr and asks him to come over. When he does, he brings a blueprint of the house so that they can locate a hidden room. Before they can find it, he is murdered, and Dale hides a piece torn from the blueprint under a tray. A storm is approaching, and the lightning knocks out the electricity. Someone phones from the garage, but when Det Anderson goes out to check, there is no one there. Detective Jones [Charles Dow Clark] arrives to help with the investigation. Dr Venrees finds the torn piece from the blueprint showing that the hidden room is behind a fireplace, but Det Anderson forces him to hand it over. When Anderson is poring over the blueprint, Venrees clobbers him with a heavy statue and locks his body in a closet. In the lightning flashes, the silhouette of the Bat can be seen peering into the window.It gets even more intriguing. Brook turns out to be a cashier from the bank and the primary suspect in the theft. Fleming Sr is seen walking on the roof when he's supposed to be out of the country. Dale finds the secret room behind a fireplace and gets locked in, along with the Bat, Mr Fleming Sr, and the money. The Bat shoots Fleming Sr. Dale escapes and leads Inspector Jones, Cornelia, and Dr Venrees to the secret room. Just as the fireplace swings open, Venrees blows out the candle, allowing whomever was in the room to escape. Finally,

A:
Where was the man found unconscious?
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