Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

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Paragraph: The Alaska Section of Epidemiology said in an update this week that it has requested help with response efforts from the Centers for Disease Control and Prevention, KTVA-TV reported Wednesday. The number of cases is the highest reported in the state since at least the 1970s, said Susan Jones, a program manager with the state Division of Public Health. “It actually can be before that but that’s as far back as we have saved data,” Jones said. Out of the 75 cases, 64 occurred in Anchorage and 66 were men, according to the state. Of the nine women, two were pregnant at the time of diagnosis. The ages of people infected ranged from 18 to 76, with 20 cases recorded in the 25 to 29 age group. Health officials also found a probable case of congenital syphilis in an infant born in March whose mother had been diagnosed last year. Symptoms of the sexually transmitted infection in its early stages include genital sores, skin rash, swollen lymph nodes, and fever, according to the CDC. The disease in the tertiary stage can damage internal organs and result in death. According to the CDC, most people with untreated syphilis do not develop symptoms of the last stage, but tertiary syphilis could develop decades after infection. “It’s easy to acquire syphilis by having sex with somebody with infection, it’s easy to have the disease and not be aware of it, and it’s also easy to treat if we catch it early,” Jones said. Syphilis can be treated with an antibiotic injection. ___ Information from: KTVA-TV, http://www.ktva.com Claim: Alaska hit with largest syphilis outbreak in 40 years.

Ex Output:
Alaska health officials have recorded 75 cases of syphilis in the state this year, marking the largest outbreak of the infectious disease in at least four decades.


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Paragraph: A panel of Food and Drug Administration advisers voted unanimously in favor of Amgen’s version of AbbVie’s Humira, a biotech drug that raked in nearly $15 billion last year, according to IMS Health. While not binding, the recommendation likely paves the way for FDA approval of the knockoff drug. For years, biotech drugs faced no competition because there was no regulatory way to approve copycat versions, even after patents had expired. If approved, Amgen’s drug would join a new wave of so-called biosimilars, which have the potential to generate billions in savings for U.S. insurers, doctors and patients. But it could take years for those savings to arrive. Evercore ISI analyst Mark Schoenebaum says the earliest Amgen could launch its product would be March 2017, though that would risk infringing patents which Abbvie says protect its drug until at least 2022. Wall Street analysts expect the patent issue to be fought in court, and then for Amgen’s drug to launch sometime between 2018 and 2022. First approved in 2002, Humira has long been among the most profitable drugs in the world. It accounted for 60 percent of Abbvie’s total revenue last year. The injectable drug, which blocks chemicals linked to inflammation, is approved for multiple uses, including rheumatoid arthritis, Crohn’s disease and psoriasis. Thousand Oaks, Calif-based Amgen is seeking FDA approval to market its version, known only as ABP 501, for seven diseases. Amgen is itself a biotech powerhouse, and it too has medications facing competition from cheaper versions. The company is working to hedge those loses by developing lower-cost versions of competitors’ drugs. Biotech drugs are powerful, injected medicines produced in living cells that are typically much more expensive than traditional, chemical-based drugs. In 2015, six of the 10 top-selling medicines globally were biotech drugs, with more than $56 billion in combined sales. The FDA only approved the first lower-cost biotech drug last March, a Novartis version of the Amgen drug Neupogen. Pfizer won approval to market a second biosimilar in April, a version of Johnson & Johnson’s Remicade, but it is not yet for sale. Questions remain about just how much savings U.S. biosimilars will deliver. Novartis’ Zarxio sells for 15 percent less than the original Neupogen. Experts predict biosimilar discounts of 15 percent to 30 percent in the U.S. In Europe, where governments regulate prices, discounts are higher. Development of lower-cost anti-inflammatory drugs like Humira is considered pivotal in reducing U.S. spending on specialty drugs, which has doubled to $150 billion since 2010, according to IMS Health. On Wednesday, the same panel of FDA advisers will review a Novartis version of Enbrel, which is marketed by Amgen. Claim: Lower-cost biotech drug gets thumbs up from FDA panel.

Ex Output:
The second-biggest selling drug in the world could get some cheaper competition in the U.S., after a federal panel endorsed an alternative version of the pricey medication used to treat rheumatoid arthritis and other inflammatory diseases.


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Paragraph: Many of China’s usually teeming cities have almost become ghost towns during the past two weeks as Communist Party rulers ordered virtual lockdowns, canceled flights, closed factories and shut schools. Even on Monday, a large number of workplaces and schools will remain closed and many white-collar employees will work from home. The scale of the potential hit to an economy that has been the engine of global growth in recent years has taken a toll on financial markets, as shares slumped and investors switched into safe-havens such as gold, bonds and the Japanese yen. China’s ambassador to Britain described the newly identified virus as “the enemy of mankind” in a BBC interview on Sunday, but added it “is controllable, is preventable, is curable”. “At this moment is very difficult to predict when we are going to have an inflection point,” Liu Xiaoming said. “We certainly hope it will come soon, but the isolation and quarantine measures have been very effective.”  China’s cabinet said it would coordinate with transport authorities to ensure the smooth return to work of employees in key industries such as food and medicines. The State Council’s special coronavirus group also said workers should return in “batches”, rather than all at once, in order to reduce infection risks. China’s National Health Commission recorded another 89 deaths on Saturday, pushing the total well above the 774 who died from SARS, or Severe Acute Respiratory Syndrome in 2002/2003. GRAPHIC: Comparing new coronavirus to SARS and MERS - here  Total confirmed coronavirus cases in China stood at 37,198, commission data showed. New infections recorded the first drop below 3,000 cases Feb. 2, at 2,656 cases. Of those, 2,147 cases were in Hubei province, the epicenter of the outbreak. The virus has also spread to at least 27 countries and territories, according to a Reuters count based on official reports, infecting more than 330 people. Two deaths have been reported outside mainland China - both of Chinese nationals. The latest patients outside China include a group of British nationals staying in a mountain village in Haute-Savoie in the Alps, French health officials said, raising fears of further infections at a busy period in the ski season. A British man who contracted the virus while attending a conference in Singapore may have infected seven other people when he stopped off at a chalet in the French village on his way home, health experts said. Those infected include a British man diagnosed in Spain and a Briton found to have the disease in the UK, both of whom appeared to have been part of the chalet group. GRAPHIC: Tracking the novel coronavirus - here  As millions of Chinese prepared to go back to work, the public dismay and mistrust of official numbers was evident on Weibo, China’s equivalent of Twitter. “What’s even more frustrating is that these are only the ‘official’ data,” said one user. “We all know we can’t purchase masks anywhere, why are we still going back to work?” said a second. “More than 20,000 doctors and nurses around the country have been sent to Hubei, but why are the numbers still rising?” asked a third. Authorities had told businesses to tack up to 10 extra days on to holidays that had been due to finish at the end of January and some restrictions continued. Gaming giant Tencent Holdings said it had asked staff to continue working from home until Feb. 21. Hebei province, which surrounds Beijing, will keep schools shut until March 1, the People’s Daily newspaper said. Several provinces have shut schools until the end of February. The local government in the southern manufacturing hub of Shenzhen, meanwhile, denied a report in the Nikkei business daily that it had blocked a plan by Apple supplier Foxconn Technology Co to resume production in China from Monday. The company would restart once inspections were completed, it said. Among the latest deaths, 81 were in Hubei. An American hospitalized in the provincial capital Wuhan, where the outbreak began, became the first confirmed non-Chinese victim. Joseph Eisenberg, professor of epidemiology at the School of Public Health at the University of Michigan, said it was too early to say whether the epidemic was peaking. “Even if reported cases might be peaking, we don’t know what is happening with unreported cases,” he said. Major cities and capitals announced new travel restrictions as concern over the spread of the virus increased. Chinese-ruled Hong Kong introduced a two-week quarantine on Saturday for all people arriving from the mainland, or who have been there during the previous 14 days. Malaysia expanded its ban on visitors from China. France issued a new travel advisory for its citizens, saying it did not recommend traveling to China unless there was an “imperative” reason. Italy asked children traveling from China to stay away from school for two weeks voluntarily. Princess Cruises, operator of the Diamond Princess cruise ship quarantined off Japan, said a further six people had tested positive, bringing the total cases aboard to 70. (This story corrects to remove in paragraph 23 reference to 53-year-old geneticist who died, citing Washington Post, after newspaper said it incorrectly identified the name and age of a U.S. citizen who died.) Claim: 'Enemy of mankind': Coronavirus deaths top SARS as China returns to work.

Ex Output:

China raised the death toll from its coronavirus outbreak to 811 on Sunday, passing the number killed globally by the SARS epidemic, as authorities made plans for millions of people returning to work after an extended Lunar New Year break.