Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

Q: Paragraph: There was no discussion of costs. The story included quantitive information about weight loss over time. It did not quantify the impact on blood pressure. The story mentioned specific side effects of this particular medication combination. To be most informative to readers, the story should have mentioned that the potential for long-term harm is not known. And the rate at which people stopped taking the drug due to side effects should have been included. While indicating that several studies had been conducted in more than 4,500 people with various characteristics, the story never mentioned whether the studies are considered definitive or not; it also did not mention that the results of these studies have not yet been published in peer-reviewed journals. And while reporting that weight loss appeared to be dose dependent, there was no discussion of how weight loss compared with those in control groups. Lastly – as the focus of the story appeared to be on an effect on blood pressure, it would seem that the story should have included some detail about the magnitude of the change. The story did not engage in overt disease mongering. The story mention that the study author and Dr. Aronne received funding from the manufacturer of this drug. It also included a quote from the president of the American Society of Hypertension who does not appear to have a financial tie to this product. There was no information about how well this product works in comparison with other approaches to weight loss. It’s pretty clear from the story that the combination of the two drugs is not yet available. The story reported that the drug was a combination of two commercially available medications. It does not appear that the story relied solely or largely on a news release. Claim: Weight Loss Pill Also Lowers Blood Pressure

A: Although highlighting the effect of this product on blood pressure, the story did not explain how much blood pressure dropped. The story also didn’t say how common the side effects are or how often people have to discontinue the medication due to side effects. It would have been helpful to remind readers of the possible pitfalls that may be ahead and that little is known about the long term use of this product in terms of both weight loss and potential risks that might result. Obesity and high blood pressure are very common conditions. There are few treatment for obesity that have been demonstrated to be enable people to lose weight and maintain that loss.
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Q: Paragraph: On July 14 2019, a Facebook user shared a photograph purportedly illustrating the risks posed by grill brushes and the metal they can leave behind attaching to food that is consumed. In an attached status update, the poster warned:I would suggest to anyone that has a metal brush to clean your grill get rid of it. This is the result of eating a bristle off of one. I am looking at a long recovery. — at Pelham Medical Center.In the attached image, an exposed abdomen bears a long and painful-looking scar with more than twenty staples. No other details about the image were included with the post, but the obvious inference was that this was the result of surgery that was required after inadvertently ingesting metal fragments left on a grill by a cleaning brush.No information was included about how the injury manifested or which symptoms people already exposed to grilled foods might exhibit. However, news stories from previous years indicated that even if rare, summer grilling has occasionally led to people accidentally consuming food with grill brush debris attached.In May 2015, CBS reported that a Connecticut woman had been treated for the same injury. Her symptoms were described as a “sharp” and “unusual” pain:[In May 2015], a woman in Connecticut needed emergency surgery to remove a wire barbecue brush bristle from her digestive tract — and doctors say she’s not the first. Cheryl Harrison of Wallingford, Connecticut, was rushed to the hospital by her husband after feeling a sharp and unusual pain in her stomach.That pain was caused by a single stray bristle that had fallen off the metal grill cleaning brush and found its way into the hamburger she ate. She came into the emergency room within a day because of severe abdominal pain. After a CT scan showed the wire, doctors were able to remove it from her stomach through laparoscopic surgery.The article went on to describe a similar case in which the patient was not made aware of the injury as quickly. One doctor stated the injury was difficult to identify because the small size of the bristles meant they were difficult to find:Dr. Aziz Benbrahim, her general surgeon at MidState Medical Center, told CBS News she was lucky because she came in right away. A previous patient of his who had a grill brush wire stuck in his system waited for a couple of weeks. It had punctured his intestine.“I had to open him up completely, ” said Benbrahim. “Then we remove this wire and we found out also why he had chest pain — because he also had pulmonary embolism, which is a blood clot in his lungs.”“He was just lucky he was still alive,” he added. “All from this wire.”[…]“Nobody knows the statistics, that’s the problem. The only paper published talks about 6 or 7 cases and I believe it’s a much, much more common,” Benbrahim said. “When I was talking to my colleagues at the hospital, I was surprised that all of them had at least one or two patients like this. I didn’t think it was that common. And this isn’t a very big hospital, so I assume that in a bigger hospital they would have more.”The story further noted that in one hospital, at least six patients had similar injuries from ingesting grill brush wire over an 18-month period. One year later, WTSP reported that a man in Florida was injured the same way:A warning if you plan to fire up the grill this holiday weekend. A Lakeland man discovered a hidden health hazard the hard way, and it could be on your grill right now.“This is my little parting gift,” says Clif Hennecy. It’s a souvenir from the doctor’s office that Hennecy never imagined his doctor would find stuck in his stomach during a routine checkup.“It’s just a tiny, little bristle, but it’s stainless steel,” says Hennecy.The Lakeland man says the metal bristle came from the brush he used to use to clean his grill.“It’s a scary proposition having one of those lodged inside your stomach. It can cause abscesses, and cause infections, and it can cause people to die,” Hennecy says.And in July 2017, a boy in Canada was hurt when he swallowed wire fragments:Jenna Kuchik was kicking back after a July 4 [2017] barbecue with her fiance and three children when her 4-year-old son, Oliver Schenn, began to scream in pain.Terrified, Kuchik ran for the EpiPen. Oliver, whom Kuchik and her fiance, Matt Schenn, affectionately call Ollie, has a severe nut allergy. But the boy was not exhibiting any of symptoms of a reaction — only choking, screaming and crying.Twenty-four hours and two hospitals later, Ollie would emerge from surgery after doctors removed two tiny metal fibers from his esophagus. The culprit: the family’s wire barbecue brush.That outlet included some statistics about frequency, noting it was low but acute, and possibly underreported:Barbecue brushes have caused an estimated 1,698 emergency room visits from 2002 to 2014, according to a study published in 2016 in the journal Otolaryngology-Head and Neck Surgery. The rate of injuries is low when compared to similar emergencies, like children ingesting batteries, but the study’s lead, Dr. David Chang, associate professor at the University of Missouri’s department of otolaryngology, believes the data underrepresents the total volume of injuries. Urgent care clinics and primary care doctors likely see many similar cases that aren’t covered by the data in Chang’s study.A 2018 Consumer Reports article provided alternative methods of cleaning a grill without the ubiquitous wire brush:Consider alternative cleaning tools. Depending on what type of grill you have, you might try cleaning warm grill grates with a tool such as a pumice stone or a coil-shaped bristle-free brush. Check your owner’s manual for recommendations … You can also brush loose food particles off a warm grate with a wad of crumpled-up aluminum foil. Make sure grill grates are not hot enough to burn you.The claim about ingesting grill brush wires and requiring hospitalization represents a known but rare risk. Experts advise anyone who experiences symptoms like stomach pain after consuming grilled food to seek medical attention. Instead of using a wire grill brush, consumer safety advocates advise alternative grill cleaning methods, such as aluminum foil. Claim: People sometimes ingest metal fragments from grill brushes and become seriously injured.

A: Can Grill Brushes Cause You to Ingest Metal and Become Ill?
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Q: Paragraph: But the drugmakers and industry analysts said some data in the trial were encouraging and that the medicine could still prove effective in preventing dangerous blood clots in other large trials. “Not good news, but not a death knell either,” said Michael Castor, a portfolio manager with health-care fund Sio Capital Management. He noted that the drug remains in development, including for other uses, and did show effectiveness despite missing the trial’s main goal. The stocks of both drugmakers were little changed in after-hours trading. Bristol-Myers closed unchanged at $21.98, while Pfizer fell 23 cents to $19.28, both on the New York Stock Exchange in regular trading. The Phase III trial was designed to show whether twice-daily apixaban was at least as effective as twice-daily injections of Sanofi-Aventis’ Lovenox in preventing dangerous blood clots among patients undergoing knee-replacement surgery. The failure represents another setback for two companies that had hoped apixaban would become a big seller and bolster their earnings in the face of looming generic competition within three years for their best-selling drugs. “Not to say that apixaban is buried, but this initial poor result is another in a string of poor partnering decisions that Pfizer has recently made,” said Damien Conover, an analyst with Morningstar. The drugmakers said 9 percent of knee-surgery patients receiving apixaban developed dangerous clots, versus 8.9 percent of those receiving Lovenox. The new drug, therefore, was not deemed statistically as effective as Lovenox. Bristol-Myers said this was surprising because about 16 percent of patients taking Lovenox had developed dangerous clots in earlier studies. Patients had statistically similar incidents of major bleeding, although the combined incidence of major and non-major bleeding was significantly less in patients given apixaban, the company said. Apixaban has generated excitement because it works through a new mechanism of action, by blocking a protein called Factor Xa that is instrumental in the clotting process. A similar drug, called rivaroxaban, is being co-developed by Bayer AG and Johnson & Johnson and considered slightly farther along in testing. “This would seem to benefit Johnson & Johnson and Bayer,” said Mike Krensavage, a principal of Krensavage Asset Management. “It’s another setback for Pfizer as well,” he said, referring to its string of drug failures in recent years that has driven the company’s stock to 10-year lows. Just weeks ago, Bristol-Myers described apixaban as the most promising of its medicines in late-stage studies. Analysts have said it could become a blockbuster drug, especially if it proves effective in preventing strokes among patients with atrial fibrillation, a form of irregular heartbeat. Despite the setback, the drugmakers said they remain confident in apixaban and will continue other large studies of the medicine. “This is the first of eight Phase III trials for a broad range of indications, including atrial fibrillation, and we view all of them as very significant opportunities,” said Jack Lawrence, a Bristol-Myers research official who heads the apixaban program. Claim: Bristol, Pfizer to delay clot drug after setback.

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Bristol-Myers Squibb Co and Pfizer Inc said on Tuesday their apixaban blood clot preventer failed its primary goal in a late-stage trial, and that they no longer plan to seek marketing approval next year for the pill.
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