Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: The water droplets of fog form from water vapor in the air. Fog disappears when the water droplets change back to water vapor. These changes are examples of changes of state. A change of state occurs whenever matter changes from one state to another. Common states of matter on Earth are solid, liquid, and gas. Matter may change back and forth between any two of these states. Changes of state are physical changes in matter. They are reversible changes that do not change matters chemical makeup or chemical properties. For example, when fog changes to water vapor, it is still water and can change back to liquid water again. Several processes are involved in common changes of state. They include melting, freezing, sublimation, deposition, condensation, and evaporation. The Figure 1.1 shows how matter changes in each of these processes. Q: Which two processes result in matter changing to the solid state? A: The processes are deposition, in which matter changes from a gas to a solid, and freezing, in which matter changes from a liquid to a solid. Suppose that you leave some squares of chocolate candy in the hot sun. A couple of hours later, you notice that the chocolate has turned into a puddle like the one pictured in the Figure 1.2. Q: What happened to the chocolate? A: The chocolate melted. It changed from a solid to a liquid. In order for solid chocolate to melt and change to a liquid, the particles of chocolate must gain energy. The chocolate pictured in the Figure 1.2 gained energy from sunlight. Energy is the ability to cause changes in matter, and it is always involved in changes of state. When matter changes from one state to another, it either absorbs energyas when chocolate meltsor loses energy. For example, if you were to place the melted chocolate in a refrigerator, it would lose energy to the cold air inside the refrigerator. As a result, the liquid chocolate would change to a solid Q: Why is energy always involved in changes of state? A: The energy of particles of matter determines the matters state. Particles of a gas have more energy than particles of a liquid, and particles of a liquid have more energy than particles of a solid. Therefore, in order for matter to change from a solid to a liquid or from a liquid to a gas, particles of matter must absorb energy. In order for matter to change from a gas to a liquid or from a liquid to a solid, particles of matter must lose energy.

Answer: which process does not involve matter in the liquid state?


Question: Nuclear receptor co-repressor (N-CoR) plays important role in transcriptional control mediated by several tumor suppressor proteins. Recently, we reported a role of misfolded-conformation dependent loss (MCDL) of N-CoR in the activation of oncogenic survival pathway in acute promyelocytic leukemia (APL). Since N-CoR plays important role in cellular homeostasis in various tissues, therefore, we hypothesized that an APL like MCDL of N-CoR might also be involved in other malignancy. Indeed, our initial screening of N-CoR status in various leukemia and solid tumor cells revealed an APL like MCDL of N-CoR in primary and secondary tumor cells derived from non-small cell lung cancer (NSCLC). The NSCLC cell specific N-CoR loss could be blocked by Kaletra, a clinical grade protease inhibitor and by genistein, an inhibitor of N-CoR misfolding previously characterized by us. The misfolded N-CoR presented in NSCLC cells was linked to the amplification of ER stress and was subjected to degradation by NSCLC cell specific aberrant protease activity. In NSCLC cells, misfolded N-CoR was found to be associated with Hsc70, a molecular chaperone involved in chaperone mediated autophagy (CMA). Genetic and chemical inhibition of Lamp2A, a rate limiting factor of CMA, significantly blocked the loss of N-CoR in NSCLC cells, suggesting a crucial role of CMA in N-CoR degradation. These findings identify an important role of CMA-induced degradation of misfolded N-CoR in the neutralization of ER stress and suggest a possible role of misfolded N-CoR protein in the activation of oncogenic survival pathway in NSCLC cells.

Answer: Which is the receptor for substrates of Chaperone Mediated Autophagy?


Question: Energy levels (also called electron shells) are fixed distances from the nucleus of an atom where electrons may be found. Electrons are tiny, negatively charged particles in an atom that move around the positive nucleus at the center. Energy levels are a little like the steps of a staircase. You can stand on one step or another but not in between the steps. The same goes for electrons. They can occupy one energy level or another but not the space between energy levels. The model in the Figure 1.1 shows the first four energy levels of an atom. Electrons in energy level I (also called energy level K) have the least amount of energy. As you go farther from the nucleus, electrons at higher levels have more energy, and their energy increases by a fixed, discrete amount. Electrons can jump from a lower to the next higher energy level if they absorb this amount of energy. Conversely, if electrons jump from a higher to a lower energy level, they give off energy, often in the form of light. This explains the fireworks pictured above. When the fireworks explode, electrons gain energy and jump to higher energy levels. When they jump back to their original energy levels, they release the energy as light. Different atoms have different arrangements of electrons, so they give off light of different colors. Q: In the atomic model Figure 1.1, where would you find electrons that have the most energy? A: Electrons with the most energy would be found in energy level IV. The smallest atoms are hydrogen atoms. They have just one electron orbiting the nucleus. That one electron is in the first energy level. Bigger atoms have more electrons. Electrons are always added to the lowest energy level first until it has the maximum number of electrons possible. Then electrons are added to the next higher energy level until that level is full, and so on. How many electrons can a given energy level hold? The maximum numbers of electrons possible for the first four energy levels are shown in the Figure 1.1. For example, energy level I can hold a maximum of two electrons, and energy level II can hold a maximum of eight electrons. The maximum number depends on the number of orbitals at a given energy level. An orbital is a volume of space within an atom where an electron is most likely to be found. As you can see by the images in the Figure 1.2, some orbitals are shaped like spheres (S orbitals) and some are shaped like dumbbells (P orbitals). There are other types of orbitals as well. Regardless of its shape, each orbital can hold a maximum of two electrons. Energy level I has just one orbital, so two electrons will fill this energy level. Energy level II has four orbitals, so it takes eight electrons to fill this energy level. Q: Energy level III can hold a maximum of 18 electrons. How many orbitals does this energy level have? A: At two electrons per orbital, this energy level must have nine orbitals. Electrons in the outermost energy level of an atom have a special significance. These electrons are called valence electrons, and they determine many of the properties of an atom. An atom is most stable if its outermost energy level contains as many electrons as it can hold. For example, helium has two electrons, both in the first energy level. This energy level can hold only two electrons, so heliums only energy level is full. This makes helium a very stable element. In other words, its atoms are unlikely to react with other atoms. Consider the elements fluorine and lithium, modeled in the Figure 1.3. Fluorine has seven of eight possible electrons in its outermost energy level, which is energy level II. It would be more stable if it had one more electron because this would fill its outermost energy level. Lithium, on the other hand, has just one of eight possible electrons in its outermost energy level (also energy level II). It would be more stable if it had one less electron because it would have a full outer energy level (now energy level I). Both fluorine and lithium are

Answer:
any atom is most stable when its outermost energy level contains