TASK DEFINITION: Given a document, generate a short title of the document. The title should convey the main idea/event/topic about which the document is being written. Note that URLs in the text have been replaced with [Link].
PROBLEM: Melbourne (AFP) â  Croatiaâs Marin Cilic  won  his  100th Grand Slam match as  he  mastered Spainâs Pablo Carreno Busta in four sets to reach the quarter-finals of the Australian Open on Sunday.
 Cilic  reached the last eight in Melbourne for the second time and also claimed  his  11th Slam quarter-final to equal Goran Ivanisevicâs record for appearances at that stage of the majors by a Croatian man.
âThere were lots of ups and downs and Pablo gave me a lot of trouble in that third set where he was twice a break up and it was difficult mentally â  Cilic  said.
â We  had a lot of tough rallies in difficult humid conditions so I was really glad how I stayed in there mentally and really played well in the end.â
 Cilic  served 20 aces  broke serve six times and made a total of 73 winners as well as winning the majority of the long rallies.
âThatâs my style of play. Pablo is extremely solid from the back of the court and has great shots both on the forehand and backhand and  he  was serving really good today â  Cilic  said.
 Cilic  said  he  faced a big challenge against either Nadal or Schwartzman in the quarter-finals.
âI have played great tennis from the first round against tough opponents and now I am really looking to the next match  it will be definitely be a big challenge â  he  said.

SOLUTION: Cilic brings up 100 as he makes Open quarters

PROBLEM: A few years ago he began working with Dr. Jenny Chang  medical director of the Lester and Sue Smith Breast Center at Baylor College of Medicine.
 Chang had performed a number of biopsies on breast cancer patients  both on those whose cancers were confined to the breast and on those whose cancers had metastasized to the brain.
 From those biopsies  Chang said she had identified a number of genetic pathways ways in which gene mutations affected the ability of the cancer to spread unique to patients who developed metastatic breast cancer.
 "But I had a lot of trouble with the data and trying to translate it into clinical practice " she said. She couldn't find her way out from beneath the avalanche of data.
 So she turned to Wong.
 Using his mathematical modeling  Wong sifted through Chang's data and the large databases of genome and clinical trial data. Out of that  he identified several candidate drugs to impair the genetic pathways that helped the cancer spread.
Chang's data and the large databases of genome and clinical trial data. Out of that  he identified several candidate drugs to impair the genetic pathways that helped the cancer spread.
 One of them  a drug named sunitinib  which treats a kidney cancer called renal cell carcinoma  emerged as the best bet. Chang then tested the drug in mice  and the study showed it prevented breast cancer from spreading to the brain.
 She has already begun a Phase II clinical trial of the drug  enrolling nine patients with metastatic breast cancer  and she is looking for more.
 "The drug is very well-tolerated by patients  and so far the trial is going very well " Chang said.
 But by using an existing drug  Chang and Wong could skip the lengthy Phase I  during which a drug is checked for safety. If Chang's tests go well  sunitinib could be on the market within a few years for metastatic breast cancer.

SOLUTION: IN OLD DRUGS RESEARCHER LOOKS FOR NEW TREATMENTS

PROBLEM: SEATTLE (AP) â In the view of  Mike Hopkins    his  first season as the head coach at Washington will be filled basically with freshmen.
That's not to be taken in the literal sense. What  Hopkins  means is that with a new coaching staff  a new style and new expectations  even the players that are returning from last year are just like the incoming freshmen.
"I think the biggest thing is we've focused on the day-to-day  how we're going to do the process of getting better "  Hopkins  said. "That's the standard of excellence every day and everybody here is learning a new system. A lot of the players end up being freshmen again because they're learning  from our zone to our press to how we're going to play offensively  defensively. I think they've made the transition pretty smooth."
After spending 22 seasons as an assistant at Syracuse and being the presumptive replacement for Jim Boeheim when he retired   Hopkins  left behind everything  he  knew in upstate New York and accepted the job of rebuilding the Washington program after the Huskies fired Lorenzo Romar following 15 seasons.
 Hopkins  also had to recruit those who slogged through a 9-22 record a season ago to keep them around. A number considered leaving. Most  including starters David Crisp  Noah Dickerson and Matisse Thybulle  all ended up staying with the chance to create the new foundation for the next chapter at Washington.
"The biggest concern with a new coach is the buy-in there "  Hopkins  said. "I think from the beginning our staff did a great job of really connecting with the kids  working with them  developing them  getting them to stay  that was our first priority. I'm very happy with the guys."
IN THE ZONE: Yes  Washington will play zone. Yes  it will be the same zone defense that  Hopkins  helped teach at Syracuse.
Defense was a major problem in the waning years of Romar's tenure. The Huskies' defense was more of a liability that an asset. How  Hopkins  is able to implement the zone will be important since the Huskies don't have a lot of size on the interior. A year ago  Washington allowed 81 points per game  11th in the conference.
"I know the benefits of it. The biggest thing I want to do is control tempo. So if you're fast  I can slow you down; if you're slow  I can speed you up  " Hopkins  said.
FINDING SCORING: One of  Hopkins ' first tasks will be finding enough scoring. Crisp is Washington's leading returning scorer at 13.8 points per game  while Dickerson averaged 12.5 points last season. But the Huskies don't have an obvious scorer on the roster that can carry the load or get points in crucial situations. In recent seasons  the Huskies have had Markelle Fultz  Andrew Andrews and C.J. Wilcox. Fultz averaged 23.2 points last season  while Andrews scored 20.9 per game the season before.
"You try and figure out how you're going to score 70 to 75 points per game and who is going to do it "  Hopkins  said. "That's been one of the processes."
DIFFICULT BEGINNING:  Hopkins  certainly isn't shying away from having a challenging schedule to begin  his  Washington tenure.

SOLUTION:
All new at Washington under first