Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
Throughout its history, chronic myeloid leukemia (CML) has set precedents for cancer research and therapy. These range from the identification of the first specific chromosomal abnormality associated with cancer to the development of imatinib as a specific, targeted therapy for the disease. The successful development of imatinib as a therapeutic agent for CML can be attributed directly to decades of scientific discoveries. These discoveries determined that the BCR-ABL tyrosine kinase is the critical pathogenetic event in CML and an ideal target for therapy. This was confirmed in clinical trials of imatinib, with imatinib significantly improving the long-term survival of patients with CML. Continuing in this tradition of scientific discoveries leading to improved therapies, the understanding of resistance to imatinib has rapidly led to strategies to circumvent resistance. Continued studies of hematologic malignancies will allow this paradigm of targeting molecular pathogenetic events to be applied to many additional hematologic cancers.

Ex Output:
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Ex Input:
The tradition of birthday parties started in Europe a long time ago. It was feared that evil spirits were particularly attracted to people on their birthdays. To protect them from harm, friends and family members would come to stay with the birthday person and bring good thoughts and wishes. Giving gifts brought even more good cheer to keep away from the evil spirits. This is how birthday parties began. The following are some countries' birthday traditions: Canada---Putting butter on the nose. In Atlantic Canada, the birthday child's nose is put butter on for good luck. China---Noodles for lunch. The birthday child pays respect to his / her parents and receives a gift of money. Friends and relatives are invited to lunch and noodles are served to wish the birthday child a long life. England---Money cakes. Certain symbolic objects are mixed into the birthday cake as it is being prepared. If your piece of cake has a coin in it, you will be rich. Ireland---Birthday bump . The birthday child is lifted upside down and " bumped" on the floor for good luck. Italy---Pulling ears. The child's ears are pulled as many times as how old he / she is turning. Japan---New clothes. The birthday child wears new clothes to mark the occasion. New Zealand---Birthday claps. After the candles are hit, the happy birthday song is sung loudly and often out of tune and then the birthday person receives a clap for each year he / she has been alive and then one for good luck. The United States---Cake, candles and the birthday song. A cake is made, and candles are put on top based on how old the person is.

Ex Output:
According to the passage, in which country can the birthday children probably receive a gift of money?


Ex Input:
Have you ever been to the world's smallest bookstore? The World's Smallest Bookstore,whose official name is just these three words,sits quietly about 100 miles northeast of Toronto. The bookstore is about 10 feet by 10 feet,so it is easy to imagine how tiny it really is.The bookstore is open 24 hours a day.Inside the bookstore are various books,especially literary books and classic authors' works.So if you are looking for something less popular,you may get a bit disappointed there. Another special feature of this bookstore is that each book only costs three dollars.All the expenses are paid on the honor system,which means buyers should make a note of what they've bought and leave their money by themselves.So the tools of the trade in this bookstore are quite simple: pens,papers,light bulbs and a label-maker. In order to catch passers-by's attention,the billboards of the bookstore are several times bigger than the store itself.With these large eye-catchers,many people are willing to stop by and have a visit.

Ex Output:

What's the passage mainly about?