Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Example Input: Context: It is unanimously accepted that there is an unmet need for pain medications that are both effective and safe. Unfortunately, no really novel analgesics have been approved over the past three decades. In view of both experimental and clinical evidence of a major role for nerve growth factor (NGF) in the generation and maintenance of a wide range of pain states, drug discovery efforts focusing on the development of anti-NGF agents have aroused particular interest. Several humanized anti-NGF monoclonal antibodies (mAbs) have entered clinical trials as potential analgesics. In this respect, tanezumab is at an advanced stage of clinical development while fulranumab, fasinumab and ABT-110, previously known as PG110, are in early phases of clinical development. This Current Opinion article aims at describing the rationale for targeting NGF for pain, reviewing the analgesic efficacy and safety of anti-NGF agents based on data from fully published studies, conference abstracts, and the US Food and Drug Administration (FDA) website, and discussing the possible future of these agents in managing chronic pain. Anti-NGF mAbs produced significant pain relief and functional improvement in patients with osteoarthritis of the knee and/or hip. Conversely, studies in non-specific lower back pain generated mixed results; overall, this condition appeared to be less responsive to anti-NGF agents than osteoarthritis. Finally, there was no conclusive evidence of the effectiveness of anti-NGF mAbs in some types of chronic visceral or neuropathic pain. Furthermore, these studies raised safety concerns about anti-NGF mAbs. As a class, these drugs may cause or worsen peripheral neuropathies. But the most problematic issue-which prompted the FDA to place studies of these compounds on clinical hold in 2010-was rapid joint destruction leading to joint replacement surgery. The aetiologies of these side effects have been much debated and their pathophysiology is poorly understood. After an Arthritis Advisory Committee meeting held in March 2012, pharmaceutical companies negotiated with the FDA on the conditions for restarting clinical studies. Although the FDA lifted its clinical hold, there remain many unresolved issues about the long-term efficacy and safety of anti-NGF mAbs. While acknowledging that the future of these drugs is unforeseeable, it appears that they may not be the safe and effective painkillers that have been awaited for decades. 
 Question: What is the target of tanezumab?
Example Output: ngf

Example Input: Context: The photo above represents water in three common states of matter. States of matter are different phases in which any given type of matter can exist. There are actually four well-known states of matter: solid, liquid, gas, and plasma. Plasma isnt represented in the iceberg photo, but the other three states of matter are. The iceberg itself consists of water in the solid state, and the lake consists of water in the liquid state. Q: Where is water in the gaseous state in the above photo? A: You cant see the gaseous water, but its there. It exists as water vapor in the air. Q: Water is one of the few substances that commonly exist on Earth in more than one state. Many other substances typically exist only in the solid, liquid, or gaseous state. Can you think of examples of matter that usually exists in just one of these three states? A: Just look around you and you will see many examples of matter that usually exists in the solid state. They include soil, rock, wood, metal, glass, and plastic. Examples of matter that usually exist in the liquid state include cooking oil, gasoline, and mercury, which is the only metal that commonly exists as a liquid. Examples of matter that usually exists in the gaseous state include oxygen and nitrogen, which are the chief gases in Earths atmosphere. A given kind of matter has the same chemical makeup and the same chemical properties regardless of its state. Thats because state of matter is a physical property. As a result, when matter changes state, it doesnt become a different kind of substance. For example, water is still water whether it exists as ice, liquid water, or water vapor. The most common states of matter on Earth are solids, liquids, and gases. How do these states of matter differ? Their properties are contrasted in the Figure 1.1. Click image to the left or use the URL below. URL: Properties of matter in different states. Q: The Figure 1.2 shows that a liquid takes the shape of its container. How could you demonstrate this? A: You could put the same volume of liquid in containers with different shapes. This is illustrated below with a beaker (left) and a graduated cylinder (right). The shape of the liquid in the beaker is short and wide like the beaker, while the shape of the liquid in the graduated cylinder is tall and narrow like that container, but each container holds the same volume of liquid. Q: How could you show that a gas spreads out to take the volume as well as the shape of its container? A: You could pump air into a bicycle tire. The tire would become firm all over as air molecules spread out to take the shape of the tire and also to occupy the entire volume of the tire. 
 Question: the only state in which matter has a fixed shape is
Example Output: solid.

Example Input: Context: Restless legs syndrome (RLS) has gradually been recognized as a cause for insomnia in adults, but there have been few reports about children with RLS in Japan. Here we described seven pediatric RLS patients. All of the parents of our patients had difficult times to make their children sleep due to irritability, restlessness, and demanding bedtime routines. All patients had asked their parents to rub their feet in bed, and it took more than half an hour to soothe them until they fell asleep. Their mothers had been exhausted from this night-time routine. However, they did not consider the routine abnormal, as it had been their habitual behavior since infancy. Some parents were too distressed or embarrassed to describe the symptoms of their child properly. Five patients had clear family history and none had obvious periodic leg movements during sleep. All patients showed low levels of ferritin and iron supplementation was effective in five cases. In the severest two cases, pramipexole, but not iron, was dramatically effective. Both patients started to show RLS symptoms in the early days of infancy, which may suggest more severe hereditary dopaminergic dysfunction. RLS does occur in childhood and pediatricians should bear it in mind as one of the differential diagnoses when seeing children who are irritated and/or having difficulty in initiating their sleep. 
 Question: Which deficiency is the cause of restless leg syndrome?
Example Output:
iron