Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Molecular abnormalities caused by the hybrid Bcr-Abl gene are causally associated with the development and progression of Philadelphia chromosome-positive (Ph(+)) chronic myelogenous leukemia (CML). Imatinib mesylate (STI571), a specific Bcr-Abl tyrosine-kinase signal-transduction inhibitor, has shown encouraging activity in phase I and II studies of CML. Here, we describe the use of imatinib mesylate to treat 75 patients in blast-phase CML (median age, 53 years; 65 with nonlymphoid and 10 with lymphoid blasts), and compare the results with those of a historical control group treated with standard cytarabine-based therapy. Imatinib mesylate was given as oral doses at 300 to 1000 mg per day and was the first salvage therapy for 47 patients. The objective response rate was 52% (39 of 75 patients: 16 had complete and 3 had partial hematologic response; 12 had hematologic improvement; 7 returned to second chronic phase; and 1 had a complete response in extramedullary blastic disease). Response rates were not different between nonlymphoid and lymphoid groups. The cytogenetic response rate was 16% (12 patients: 5 complete, 3 partial [Ph(+) below 35%], and 4 minor [Ph(+), 34% to 90%]). The estimated median overall survival was 6.5 months; the estimated 1-year survival was 22%. Response to therapy (landmark analysis at 8 weeks) was associated with survival prolongation. Compared with standard cytarabine combinations, imatinib mesylate therapy was less toxic and produced a higher response rate (55% versus 29%, P =.001), longer median survival (7 versus 4 months, P =.04), and lower 4-week induction mortality (4% versus 15%, P =.07). Imatinib mesylate is currently being tested in combination with other drugs to improve the prognosis for blast-phase CML.
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

Pittosporum viridulatum is a critically endangered species of plant in the Pittosporaceae family.
What is the conservation status of Pittosporum viridulatum?

It's not the first movie to show the end of the world. But in the latest box office hit 2012 it is neither aliens nor a killer disease that threaten the human race, but climate change. Some say the film lacks good dialogue and its science is questionable, others believe German director Roland Emmerich makes up for these flaws in special effects. An earthquake destroys the White House and Yellow stone National Park ends up in flames. Emmerich borrows from the old Mayan story which says, that the world will end in 2012.He is being criticized for Internet rumors about doomsday "There is no factual basis for these claims,'' NASA said on its website. "Credible scientists worldwide know of no threat connected with 2012,'' it insisted. "After all, our planet has been getting along just fine for more than 4 billion years, " they added. According to the UK's Daily Telegraph, it was first thought that the disaster would happen in May 2003. When the world continued, supporters picked the last day of the Mayan calendar. "Every culture has a myth of destruction , just as they have a myth of creation. These myths |of destruction tend to surface during times of crisis , " Michael A. Ryan, an assistant profess of history,speaking to Purdue University News. Ryan studies apocalyptic themes from the Middle Ages at the US university. "Today's current economic climate is a state of crisis for many people who are worried whether they can afford to feed themselves,"he added.

What led to the end of the world according to the film 2012?