In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Example Input: Question: What kind of validity does the degree of confidence refer to, with which it can be inferred that the cause-effect relationships between the variables of an investigation are interpretable in the sense suggested by the researcher? 
 Options:  <1> Internal validity <2> External validity <3> Discriminant validity <4> Ecological validity <5> Construct validity
Example Output: 1

Example Input: Question: A patient with Diabetes Mellitus type 1, which starts with high fever should: 
 Options:  <1> Assess the evolution of fever and wait. <2> Do not eat <3> Assess the need to increase insulin. <4> Drink plenty of water. <5> Do not administer insulin.
Example Output: 3

Example Input: Question: The cyclization of monosaccharides: 
 Options:  <1> It is an enzymatically catalyzed reaction. <2> It gives rise to enantiomers D and L. <3> It happens in the trios and tetrosas. <4> Generates a new asymmetric C, called anomeric C. <5> In ketoses it is produced by the formation of a hemiacetal bond.
Example Output:
4