In this task, you are given a sentence. You are expected to recognize the name of gene or protein. Although there might be several correct answers, you need to write one of them.

[EX Q]:  This study investigated expression of the SART3 antigen in breast cancer to explore an appropriate molecule for use in specific immunotherapy of breast cancer patients .
[EX A]: SART3 antigen

[EX Q]:  The discordant mutants may reflect interactions with a variable domain of a conserved component or unique interactions with specialized components of the basal transcription apparatus in different cells .
[EX A]: variable domain

[EX Q]:  In summary , whilst intensive investigations are in progress to target the many HIF - 1 effectors , the results herein indicate that blocking hypoxia - inducible pathways and enhancing NK - mediated antitumor immunity by targeting HIF - 1 itself may be advantageous , especially when combined with cancer immunotherapy .
[EX A]:
HIF - 1