Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

Q: Question: Does extended pattern prostate biopsy minimize the volume-grade bias in prostate cancer detection?
Answer: Although more high grade cancers are detected with extended pattern biopsy, there is no differential upgrading with respect to prostate volume. Based on these observations extended prostate sampling in trials of agents that decrease prostate volume would have minimal impact on volume-grade associations.

A: no
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Q: Question: Does peroxiredoxin 1 promote pancreatic cancer cell invasion by modulating p38 MAPK activity?
Answer: Prdx1 associates with the formation of membrane protrusions through modulation of the activity of p38 MAPK, which in turn promotes PDAC cell invasion.

A: yes
****
Q: Question: Do [ Angiogenesis and density of dendritic cells correlate with metachronous distant metastases after curative surgery of rectal carcinoma ]?
Answer: Angiogenesis and density of dendritic cells in rectal cancer are not prognostic factors for metachronous distant metastasis and, therefore, cannot serve as selection parameters for adjuvant therapy.

A:
no
****