Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: Einsteinium was discovered as a component of the debris of the first hydrogen bomb explosion in 1952, and named after Albert Einstein.
Example Output: When was Einsteinium first discovered?

Example Input: Big Pumpkin is a children's book written by Erica Silverman, illustrated by S. D. Schindler, and published by Aladdin Paperbacks in 1992.
Example Output: What is the name of the publisher of Big Pumpkin?

Example Input: Common cellular and molecular mechanisms including protein aggregation and inclusion body formation are involved in many neurodegenerative diseases. -Synuclein is a major component of Lewy bodies in Parkinson's disease (PD) as well as in glial cytoplasmic inclusions in multiple system atrophy (MSA). Tau is a principal component of neurofibrillary and glial tangles in tauopathies. Recently, TDP-43 was identified as a component of ubiquitinated inclusions in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. PD is traditionally considered a movement disorder with hallmark lesions in the brainstem pigmented nuclei. However, pathological changes occur in widespread regions of the central and peripheral nervous systems in this disease. Furthermore, primary glial involvement ("gliodegeneration") can be observed in PD and MSA as well as in tauopathy. The present article reviews abnormal protein accumulation and inclusion body formation inside and outside the central nervous system.
Example Output:
Which is the primary protein component of Lewy bodies?