Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Corynebacterium minutissimum is the bacteria that leads to cutaneous eruptions of erythrasma and is the most common cause of interdigital foot infections. It is found mostly in occluded intertriginous areas such as the axillae, inframammary areas, interspaces of the toes, intergluteal and crural folds, and is more common in individuals with diabetes mellitus than other clinical patients. This organism can be isolated from a cutaneous site along with a concurrent dermatophyte or Candida albicans infection. The differential diagnosis of erythrasma includes psoriasis, dermatophytosis, candidiasis and intertrigo, and methods for differentiating include Wood's light examination and bacterial and mycological cultures. Erythromycin 250mg four times daily for 14 days is the treatment of choice and other antibacterials include tetracycline and chloramphenicol; however, the use of chloramphenicol is limited by bone marrow suppression potentially leading to neutropenia, agranulocytosis and aplastic anaemia. Further studies are needed but clarithromycin may be an additional drug for use in the future. Where there is therapeutic failure or intertriginous involvement, topical solutions such as clindamycin, Whitfield's ointment, sodium fusidate ointment and antibacterial soaps may be required for both treatment and prophylaxis. Limited studies on the efficacy of these medications exist, however, systemic erythromycin demonstrates cure rates as high as 100%. Compared with tetracyclines, systemic erythromycin has greater efficacy in patients with involvement of the axillae and groin, and similar efficacy for interdigital infections. Whitfield's ointment has equal efficacy to systemic erythromycin in the axillae and groin, but shows greater efficacy in the interdigital areas and is comparable with 2% sodium fusidate ointment for treatment of all areas. Adverse drug effects and potential drug interactions need to be considered. No cost-effectiveness data are available but there are limited data on cost-related treatment issues. A guideline is proposed for the detection, evaluation, treatment and prophylaxis of this cutaneous eruption.
Which bacteria causes erythrasma?

The Bacillus anthracis toxin genes, cya, lef, and pag, can be viewed as a regulon, in which transcription of all three genes is activated in trans by the same regulatory gene, atxA, in response to the same signal, CO2. In atxA+ strains, toxin gene expression is increased 5- to 20-fold in cells grown in 5% CO2 relative to cells grown in air. CO2-enhanced toxin gene transcription is not observed in atx4-null mutants. Here, we used two independent techniques to obtain evidence for additional CO2-induced atxA-regulated genes. First, total protein preparations from atxA4+ and atxA isolates grown in 5% CO2 and in air were examined by two-dimensional electrophoresis. Comparison of the resulting protein patterns indicated that synthesis of non-toxin proteins is influenced by growth in elevated CO2 and the toxin gene regulator, atxA. Second, we generated random transcriptional lacZ fusions in B. anthracis with transposon Tn917-LTV3. Transposon-insertion libraries were screened for mutants expressing CO2-enhanced atxA-dependent beta-galactosidase activity. DNA sequence analysis of transposon insertion sites in 17 mutants carrying CO2- and atxA-regulated fusions revealed 10 mutants carrying independent insertions on the 185-kb toxin plasmid pXO1 which did not map to the toxin genes. The tcr-lacZ fusion mutants (tcr for toxin coregulated) were Tox+, indicating that these genes may not be involved in anthrax toxin gene activation. Our data indicate a clear association of atxA with CO2-enhanced gene expression in B. anthracis and provide evidence that atxA regulates genes other than the structural genes for the anthrax toxin proteins.
Which metabolite activates AtxA?

We are lucky to have an atmosphere on Earth. The atmosphere supports life, and is also needed for the water cycle and weather. The gases of the atmosphere even allow us to hear. Most of the atmosphere is nitrogen, but it doesnt do much. Carbon dioxide and oxygen are the gases in the atmosphere that are needed for life. Plants need carbon dioxide for photosynthesis. They use sunlight to change carbon dioxide and water into food. The process releases oxygen. Without photosynthesis, there would be very little oxygen in the air. Other living things depend on plants for food. These organisms need the oxygen plants release to get energy out of the food. Even plants need oxygen for this purpose. The atmosphere protects living things from the Suns most harmful rays. Gases reflect or absorb the strongest rays of sunlight. Figure 15.1 models this role of the atmosphere. Gases in the atmosphere surround Earth like a blanket. They keep the temperature in a range that can support life. The gases keep out some of the Suns scorching heat during the day. At night, they hold the heat close to the surface, so it doesnt radiate out into space. Figure 15.2 shows the role of the atmosphere in the water cycle. Water vapor rises from Earths surface into the atmosphere. As it rises, it cools. The water vapor may then condense into water droplets and form clouds. If enough water droplets collect in clouds they may fall as rain. This how freshwater gets from the atmosphere back to Earths surface. Without the atmosphere, there would be no clouds or rain. In fact, there would be no weather at all. Most weather occurs because the atmosphere heats up more in some places than others. Weather makes life interesting. Weather also causes weathering. Weathering is the slow wearing down of rocks on Earths surface. Wind-blown sand scours rocks like sandpaper. Glaciers of ice scrape across rock surfaces like a file. Even gentle rain may seep into rocks and slowly dissolve them. If the water freezes, it expands. This eventually causes the rocks to crack. Without the atmosphere, none of this weathering would happen. Sound is a form of energy that travels in waves. Sound waves cant travel through empty space, but they can travel through gases. Gases in the air allow us to hear most of the sounds in our world. Because of air, you can hear birds singing, horns tooting, and friends laughing. Without the atmosphere, the world would be a silent, eerie place. Air is easy to forget about. We usually cant see it, taste it, or smell it. We can only feel it when it moves. But air is actually made of molecules of many different gases. It also contains tiny particles of solid matter. Figure 15.3 shows the main gases in air. Nitrogen and oxygen make up 99 percent of air. Argon and carbon dioxide make up much of the rest. These percentages are the same just about everywhere in the atmosphere. Air also includes water vapor. The amount of water vapor varies from place to place. Thats why water vapor isnt included in Figure 15.3. It can make up as much as 4 percent of the air. Ozone is a molecule made of three oxygen atoms. Ozone collects in a layer in the stratosphere. Air includes many tiny particles. The particles may consist of dust, soil, salt, smoke, or ash. Some particles pollute the air and may make it unhealthy to breathe. But having particles in the air is very important. Tiny particles are needed for water vapor to condense on. Without particles, water vapor could not condense. Then clouds could not form and Earth would have no rain. We usually cant sense the air around us unless it is moving. But air has the same basic properties as other matter. For example, air has mass, volume and, of course, density. Density is mass per unit volume. Density is a measure of how closely molecules are packed together. The closer together they are, the greater the density. Since air

main gas in Earths atmosphere