Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
A cardiovascular disease (CVD) is any disease that affects the cardiovascular system. But the term is usually used to describe diseases that are linked to atherosclerosis. Atherosclerosis ( Figure 1.1) is an inflammation of the walls of arteries that causes swelling and a buildup of material called plaque. Plaque is made of cell pieces, fatty substances, calcium, and connective tissue that builds up around the area of inflammation. As a plaque grows, it stiffens and narrows the artery, which decreases the flow of blood through the artery. Atherosclerosis normally begins in late childhood and is typically found in most major arteries. It does not usually have any early symptoms. Causes of atherosclerosis include a high-fat diet, high cholesterol, smoking, obesity, and diabetes. Atherosclerosis becomes a threat to health when the plaque buildup prevents blood circulation in the heart or the brain. A blocked blood vessel in the heart can cause a heart attack. Blockage of the circulation in the brain can cause a stroke. Ways to prevent atherosclerosis include eating healthy foods, getting plenty of exercise and not smoking. These three factors are not as hard to control as you may think. If you smoke, STOP. Start a regular exercise program and watch what you eat. A diet high in saturated fat and cholesterol can raise your cholesterol levels, which makes more plaque available to line artery walls and narrow your arteries. Cholesterol and saturated fats are found mostly in animal products such Atherosclerosis is sometimes referred to as hardening of the arteries; plaque build- up decreases the blood flow through the artery. as meat, eggs, milk, and other dairy products. Check food labels to find the amount of saturated fat in a product. Also, avoid large amounts of salt and sugar. Be careful with processed foods, such as frozen dinners, as they can be high in fat, sugar, salt and cholesterol. Eat lots of fresh or frozen fruits and vegetables, smaller portions of lean meats and fish, and whole grains such as oats and whole wheat. Limit saturated fats like butter, instead choose unsaturated vegetable oils such as canola oil. Like any other muscle, your heart needs oxygen. Hearts have arteries that provide oxygen through the blood. They are known as coronary arteries. Coronary heart disease is the end result of the buildup of plaque within the walls of the coronary arteries. Coronary heart disease often does not have any symptoms. A symptom of coronary heart disease is chest pain. Occasional chest pain can happen during times of stress or physical activity. The pain of angina means the heart muscle fibers need more oxygen than they are getting. Most people with coronary heart disease often have no symptoms for many years until they have a heart attack. A heart attack happens when the blood cannot reach the heart because a blood vessel is blocked. If cardiac muscle is starved of oxygen for more than roughly five minutes, it will die. Cardiac muscle cells cannot be replaced, so once they die, they are dead forever. Coronary heart disease is the leading cause of death of adults in the United States. The image below shows the way in which a blocked coronary artery can cause a heart attack and cause part of the heart muscle to die ( Figure 1.2). Maybe one day stem cells will be used to replace dead cardiac muscle cells. Atherosclerosis in the arteries of the brain can also lead to a stroke. A stroke is a loss of brain function due to a blockage of the blood supply to the brain. Risk factors for stroke include old age, high blood pressure, having a previous stroke, diabetes, high cholesterol, and smoking. The best way to reduce the risk of stroke is to have low blood pressure.

Ex Output:
what is atherosclerosis?


Ex Input:
Molecular abnormalities caused by the hybrid Bcr-Abl gene are causally associated with the development and progression of Philadelphia chromosome-positive (Ph(+)) chronic myelogenous leukemia (CML). Imatinib mesylate (STI571), a specific Bcr-Abl tyrosine-kinase signal-transduction inhibitor, has shown encouraging activity in phase I and II studies of CML. Here, we describe the use of imatinib mesylate to treat 75 patients in blast-phase CML (median age, 53 years; 65 with nonlymphoid and 10 with lymphoid blasts), and compare the results with those of a historical control group treated with standard cytarabine-based therapy. Imatinib mesylate was given as oral doses at 300 to 1000 mg per day and was the first salvage therapy for 47 patients. The objective response rate was 52% (39 of 75 patients: 16 had complete and 3 had partial hematologic response; 12 had hematologic improvement; 7 returned to second chronic phase; and 1 had a complete response in extramedullary blastic disease). Response rates were not different between nonlymphoid and lymphoid groups. The cytogenetic response rate was 16% (12 patients: 5 complete, 3 partial [Ph(+) below 35%], and 4 minor [Ph(+), 34% to 90%]). The estimated median overall survival was 6.5 months; the estimated 1-year survival was 22%. Response to therapy (landmark analysis at 8 weeks) was associated with survival prolongation. Compared with standard cytarabine combinations, imatinib mesylate therapy was less toxic and produced a higher response rate (55% versus 29%, P =.001), longer median survival (7 versus 4 months, P =.04), and lower 4-week induction mortality (4% versus 15%, P =.07). Imatinib mesylate is currently being tested in combination with other drugs to improve the prognosis for blast-phase CML.

Ex Output:
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Ex Input:
Only a Mother (Swedish: Bara en mor) is a 1949 Swedish drama film directed by Alf Sjoberg.

Ex Output:

Who was responsible for the direction of Only a Mother?