In this task, you are given a context, a subject, a relation, and many options. Based on the context, from the options select the object entity that has the given relation with the subject. Answer with text (not indexes).

[Q]: Context: Princeton University is a private Ivy League research university in Princeton, New Jersey, United States., Sula is a 1973 novel by Nobel Prize - winning author Toni Morrison ., Toni Morrison (born Chloe Ardelia Wofford; February 18, 1931) is an American novelist, editor, and Professor Emeritus at Princeton University. Her novels are known for their epic themes, vivid dialogue, and richly detailed characters. Among her best known novels are "The Bluest Eye" (1970), "Sula" (1973), "Song of Solomon" (1977), and "Beloved" (1987)., The Bluest Eye was written by Toni Morrison in 1970. A single mother of two sons, Morrison wrote the novel while she was teaching at Howard University . She centers the story around a young African American girl named Pecola who grows up during the years following the Great Depression in Lorain, Ohio. Due to her dark skin color, Pecola gets taunted for her appearance as the members of her community associate beauty with "whiteness". She ultimately develops an inferiority complex, which fuels her desire for blue eyes. The point of view switches between the perspective of Claudia MacTeer, the daughter of Pecola's foster parents, and multiple third-person limited viewpoints. Due to the controversial issues the book raises such as racism, incest, and child molestation, there have been numerous attempts to ban it from schools and libraries., Subject: sula , Relation: follows, Options: (A) 18 (B) 1970 (C) a (D) american girl (E) as (F) beloved (G) born (H) characters (I) child (J) community (K) daughter (L) epic (M) eye (N) february (O) february 18 (P) following (Q) is (R) it (S) mother (T) new (U) novel (V) ohio (W) parents (X) s (Y) song of solomon (Z) sons ([) sula (\) the bluest eye (]) the great depression (^) the story (_) united (`) university (a) view (b) years (c) young
[A]: the bluest eye


[Q]: Context: The PlayStation 3 (abbreviated as PS3) is a home video game console developed by Sony Computer Entertainment. It is the successor to PlayStation 2, and is part of the PlayStation brand of consoles. It competed with Microsoft's Xbox 360 and Nintendo's Wii as part of the seventh generation of video game consoles. It was first released on November 11, 2006, in Japan, November 17, 2006 in North America, and March 27, 2007 in Europe and Australia., Fry and Laurie are a successful English comedy double act, mostly active in the 1980s and 1990s. The duo consisted of Stephen Fry and Hugh Laurie, who met in 1980 through mutual friend Emma Thompson whilst all three attended the University of Cambridge. They initially gained prominence in a television sketch show, "A Bit of Fry & Laurie" (1987, 19891995), and have collaborated on numerous other projects including, most notably, the television series "Jeeves and Wooster" (19901993) in which they portrayed P. G. Wodehouse's literary characters Jeeves (Fry) and Wooster (Laurie)., Monty Pythons Flying Circus (known during the final series as just Monty Python) is a British sketch comedy series created by the comedy group Monty Python and broadcast by the BBC from 1969 to 1974. The shows were composed of surreality, risqué or innuendo-laden humour, sight gags and observational sketches without punchlines. It also featured animations by group member Terry Gilliam, often sequenced or merged with live action. The first episode was recorded on 7 September and premiered on 5 October 1969 on BBC One, with 45 episodes airing over four series from 1969 to 1974, plus two episodes for German TV., Simon John Pegg ("né" Beckingham; born 14 February 1970) is an English actor, comedian, screenwriter, and producer. He co-wrote and starred in the "Three Flavours Cornetto" trilogy of films: "Shaun of the Dead" (2004), "Hot Fuzz" (2007), and "The World's End" (2013). He and Nick Frost wrote and starred in the sci-fi film "Paul" (2011). Pegg portrayed Benji Dunn in the and Montgomery Scott in "Star Trek" (2009), "Star Trek Into Darkness" (2013), and "Star Trek Beyond" (2016), co-writing the latter., Lionhead Studios Ltd. was a British video game developer, formerly led by Peter Molyneux. It was acquired by Microsoft Studios in April 2006. Lionhead started as a breakaway from developer Bullfrog Productions, which was also founded by Molyneux. Lionhead's first game was "Black & White", a god game with elements of artificial life and strategy games. "Black & White" was published by Electronic Arts in 2001. Lionhead Studios is named after Mark Webley's hamster, which died not long after the naming of the studio., The Royal Shakespeare Company (RSC) is a major British theatre company, based in Stratford-upon-Avon, Warwickshire, England. The company employs over 1000 staff and produces around 20 productions a year from its home in Stratford-upon-Avon and plays regularly in London, Newcastle upon Tyne and on tour across the UK and internationally., Alan Bleasdale (born 23 March 1946) is an English writer, best known for social realist drama serials based on the lives of ordinary people. A former teacher, he has written for radio, stage and screen, and has also written novels., The British Broadcasting Corporation (BBC) is a British public service broadcaster. It is headquartered at Broadcasting House in London, is the world's oldest national broadcasting organisation, and is the largest broadcaster in the world by number of employees, with over 20,950 staff in total, of whom 16,672 are in public sector broadcasting; including part-time, flexible as well as fixed contract staff, the total number is 35,402., Windows Phone (WP) is a family of mobile operating systems developed by Microsoft for smartphones as the replacement successor to Windows Mobile and Zune. Windows Phone features a new user interface derived from Metro design language. Unlike Windows Mobile, it is primarily aimed at the consumer market rather than the enterprise market. It was first launched in October 2010 with Windows Phone 7. Windows Phone 8.1 is the latest public release of the operating system, released to manufacturing on April 14, 2014., Windows IoT, formerly Windows Embedded, is a family of operating systems from Microsoft designed for use in embedded systems. Microsoft currently has three different subfamilies of operating systems for embedded devices targeting a wide market, ranging from small-footprint, real-time devices to point of sale (POS) devices like kiosks. Windows Embedded operating systems are available to original equipment manufacturers (OEMs), who make it available to end users preloaded with their hardware, in addition to volume license customers in some cases., The Academy Award for Best Supporting Actress is an award presented annually by the Academy of Motion Picture Arts and Sciences (AMPAS). It is given in honor of an actress who has delivered an outstanding performance in a supporting role while working within the film industry., Dame Hilary Mary Mantel, (; born Thompson, 6 July 1952), is an English writer whose work includes personal memoirs, short stories, and historical fiction., Microsoft Corporation (commonly referred to as Microsoft or MS) is an American multinational technology company headquartered in Redmond, Washington, that develops, manufactures, licenses, supports and sells computer software, consumer electronics and personal computers and services. Its best known software products are the Microsoft Windows line of operating systems, Microsoft Office office suite, and Internet Explorer and Edge web browsers. Its flagship hardware products are the Xbox video game consoles and the Microsoft Surface tablet lineup. As of 2016, it was the world's largest software maker by revenue, and one of the world's most valuable companies., Microsoft Studios is the video game production wing for Microsoft, responsible for the development and publishing of games for the Xbox, Xbox 360, Xbox One, Games for Windows, Steam, Windows Store, and Windows Phone platforms. They were established in 2002 as Microsoft Game Studios to coincide with the already released Xbox, before being re-branded in 2011. The subsidiary had also been known as Microsoft Game Division and simply Microsoft Games before 2002. Microsoft Studios develops and publishes games in conjunction with first and third party development studios under their publishing label., Wolf Hall (2009) is an historical novel by English author Hilary Mantel, published by Fourth Estate, named after the Seymour family seat of Wolfhall or Wulfhall in Wiltshire. Set in the period from 1500 to 1535, "Wolf Hall" is a sympathetic fictionalised biography documenting the rapid rise to power of Thomas Cromwell in the court of Henry VIII through to the death of Sir Thomas More. The novel won both the Man Booker Prize and the National Book Critics Circle Award. In 2012, "The Observer" named it as one of "The 10 best historical novels"., The Xbox 360 is a home video game console developed by Microsoft. As the successor to the original Xbox, it is the second console in the Xbox series. The Xbox 360 competed with Sony's PlayStation 3 and Nintendo's Wii as part of the seventh generation of video game consoles. The Xbox 360 was officially unveiled on MTV on May 12, 2005, with detailed launch and game information divulged later that month at the Electronic Entertainment Expo (E3)., John Marwood Cleese (born 27 October 1939) is an English actor, voice actor, screenwriter, producer, and comedian. He achieved success at the Edinburgh Festival Fringe and as a scriptwriter and performer on "The Frost Report". In the late 1960s, he co-founded Monty Python, the comedy troupe responsible for the sketch show "Monty Python's Flying Circus" and the four Monty Python films: "And Now for Something Completely Different", "Monty Python and the Holy Grail", "Life of Brian" and "The Meaning of Life"., Windows 9x is a generic term referring to a series of Microsoft Windows computer operating systems produced from 1995 to 2000, which were based on the Windows 95 kernel and its underlying foundation of MS-DOS, both of which were updated in subsequent versions. This includes all versions of Windows 95 and Windows 98. Windows ME is sometimes included., Zoë Wanamaker, CBE (born 13 May 1949) is an American-born British stage, television and film actress, who has worked extensively with the Royal Shakespeare Company and the National Theatre. A nine-time Olivier Award nominee, she won for "Once in a Lifetime" (1979) and "Electra" (1998). She has also received four Tony Award nominations for her work on Broadway; for "Piaf" (1981), "Loot" (1986), "Electra" (1999), and "Awake and Sing!" (2006)., The Critics' Choice Award for Best Young Performer (Actor/Actress) is one of the awards given to people working in the motion picture industry by the Broadcast Film Critics Association. It is given for the best performance by a child actor in a motion picture., Monty Python (sometimes known as The Pythons) were a British surreal comedy group who created their sketch comedy show "Monty Python's Flying Circus", which first aired on the BBC in 1969. Forty-five episodes were made over four series. The Python phenomenon developed from the television series into something larger in scope and impact, including touring stage shows, films, numerous albums, several books, and a stage musical. The Pythons' influence on comedy has been compared to the Beatles' influence on music. The "Orlando Sentinel" referred to their sketch show as "not only one of the more enduring icons of 1970s British popular culture, but also an important moment in the evolution of television comedy.", Hot Fuzz is a 2007 British satirical action comedy film directed by Edgar Wright, written by Wright and Simon Pegg, and starring Pegg and Nick Frost. The three and the film's producer Nira Park had previously worked together on the television series "Spaced" and the 2004 film "Shaun of the Dead". The film follows two police officers attempting to solve a series of mysterious deaths in Sandford, a fictional small English town., Clinton "Clint" Eastwood Jr. (born May 31, 1930) is an American actor, filmmaker, musician, and political figure. After earning success in the Western TV series "Rawhide", he rose to international fame with his role as the Man with No Name in Sergio Leone's "Dollars" trilogy of spaghetti Westerns during the 1960s, and as antihero cop Harry Callahan in the five "Dirty Harry" films throughout the 1970s and 1980s. These roles, among others, have made Eastwood an enduring cultural icon of masculinity., Sony Corporation is the electronics business unit and the parent company of the Sony Group, which is engaged in business through its four operating components  electronics (video games, network services and medical business), motion pictures, music and financial services. These make Sony one of the most comprehensive entertainment companies in the world. Sony's principal business operations include Sony Corporation, Sony Pictures Entertainment, Sony Interactive Entertainment, Sony Music Entertainment, Sony Mobile (formerly Sony Ericsson) and Sony Financial. Sony is among the Semiconductor sales leaders by year and as of 2013, the fourth-largest television manufacturer in the world, after Samsung Electronics, LG Electronics and TCL., Electronic Arts Inc. (EA) is an American video game company headquartered in Redwood City, California. Founded and incorporated on May 28, 1982 by Trip Hawkins, the company was a pioneer of the early home computer games industry and was notable for promoting the designers and programmers responsible for its games. As of 2014, Electronic Arts was the world's fourth-largest gaming company by revenue after Tencent, Sony and Microsoft 
The company sparked controversies over its advertising efforts, and acquisition of other studios., This article is focused on English-language literature rather than the literature of England, so that it includes writers from Scotland, Wales, and the whole of Ireland, as well as literature in English from countries of the former British Empire, including the United States. However, until the early 19th century, it only deals with the literature of the United Kingdom and Ireland. It does not include literature written in the other languages of Britain., Windows Embedded Compact, formerly Windows Embedded CE and Windows CE, is an operating system subfamily developed by Microsoft as part of its Windows Embedded family of products. Unlike Windows Embedded Standard, which is based on Windows NT, Windows Embedded Compact uses a different hybrid kernel. Microsoft licenses Windows CE to original equipment manufacturers (OEMs), who can modify and create their own user interfaces and experiences, with Windows CE providing the technical foundation to do so., Monty Python and the Holy Grail is a 1975 British slapstick comedy film concerning the Arthurian legend, written and performed by the comedy group of Monty Python (Graham Chapman, John Cleese, Terry Gilliam, Eric Idle, Terry Jones, and Michael Palin), and directed by Gilliam and Jones. It was conceived during the hiatus between the third and fourth series of their BBC television series "Monty Python's Flying Circus"., Nicholas John "Nick" Frost (born 28 March 1972) is a British actor, comedian, screenwriter, producer and author. He is best known for his work in the "Three Flavours Cornetto trilogy" of films, consisting of "Shaun of the Dead" (2004), "Hot Fuzz" (2007), and "The World's End" (2013), and the television comedy "Spaced" (19992001). He also appeared in Joe Cornish's film "Attack the Block" (2011). He co-starred in the 2011 film "Paul", which he co-wrote with frequent collaborator and friend Simon Pegg. He is also well known for his various roles in the sketch show "Man Stroke Woman". He starred in "Mr. Sloane" as the title character, Jeremy Sloane., Bernard Hill (born 17 December 1944) is an English film, stage and television actor. He is known for playing Yosser Hughes, the troubled 'hard man' whose life is falling apart in Alan Bleasdale's groundbreaking 1980s TV drama "Boys from the Blackstuff" and, more recently, as the Duke of Norfolk in the BBC adaption of Dame Hilary Mantel's "Wolf Hall". He is also known for roles in blockbuster films, including Captain Edward Smith in "Titanic", King Théoden in "The Lord of the Rings" film trilogy and Luther Plunkitt, the Warden of San Quentin Prison in the Clint Eastwood film "True Crime"., The Frost Report was a satirical television show hosted by David Frost. It ran for 28 episodes on the BBC from 10 March 1966 to 26 December 1967. It introduced John Cleese, Ronnie Barker, and Ronnie Corbett to television, and launched the careers of other writers and performers., IBM PC compatible computers are those similar to the original IBM PC, XT, and AT, able to run the same software and support the same expansion cards as those. Such computers used to be referred to as PC clones, or IBM clones. They duplicate almost exactly all the significant features of the PC architecture, facilitated by IBM's choice of commodity hardware components and various manufacturers' ability to reverse engineer the BIOS firmware using a "clean room design" technique. Columbia Data Products built the first clone of the IBM personal computer by a clean room implementation of its BIOS., Peter Douglas Molyneux, OBE (born 5 May 1959) is an English video game designer and programmer. He created the god games "Populous", "Dungeon Keeper" and "Black & White" as well as "Theme Park", the "Fable" series and "Curiosity  What's Inside the Cube?" His new studio 22Cans currently works on "Godus" and the brand new hiking resource-gathering game, The Trail-A Frontier., Nicholas Caradoc Hoult (born 7 December 1989) is an English actor. Hoult made his professional acting debut at the age of seven in the 1996 film "Intimate Relations". He received recognition after landing the role of Marcus Brewer in "About a Boy", for which he was nominated for the Critics' Choice Movie Award for Best Young Performer. He received further acclaim for his performance as Tony Stonem in the E4 teen drama "Skins"., Kellie Bright (born Kelly Denise Bright, 1 July 1976) is an English actress. She is known for playing Linda Carter in the BBC soap opera "EastEnders", for which she won the 2015 British Soap Awards for Best Actress and Best Dramatic Performance. Her other television roles include Joanna Burrows in "The Upper Hand" (199096), Cassie Tyler in "Bad Girls" (2002) and Joan Trotter in "Rock & Chips" (201011). In 2015, she was the runner-up in the 13th series of the BBC One show "Strictly Come Dancing"., Anthony "Tony" Stonem is a fictional character from the British television series "Skins". He is the antagonist of the first series and the protagonist of the second series. Portrayed by Nicholas Hoult, the character was created by Bryan Elsley; Tony was the series' central character in its first and second series, from 20072008. In the first series, the character is considered an antihero, and in some respects his actions are very antagonistic due to his antisocial tendencies. However, this changes in the second series after he becomes a victim of a subdural hematoma and, as a result, becomes more vulnerable. Hoult, along with the other starring actors of the first two series, departed the show after its second season. The character was subsequently alluded to in episodes of the third and fourth series, which centred on Tony's sister Effy, played by Kaya Scodelario. In the 2011 North American adaptation of the show, Tony is played by actor James Newman, and the character's surname is changed to Snyder., EastEnders is a British soap opera; the first episode was broadcast in the United Kingdom on BBC One on 19 February 1985. "EastEnders" storylines examine the domestic and professional lives of the people who live and work in the fictional London Borough of Walford in the East End of London. The series primarily centres on the residents of Albert Square, a Victorian square of terraced houses, and its neighbouring streets, namely Bridge Street, Turpin Road and George Street. The area encompasses a pub, street market, night club, community centre, funeral parlour, café, wine bar, various other small businesses, a park and allotments., Fable II is an action role-playing open world video game in the "Fable" game series developed by Lionhead Studios and published by Microsoft Game Studios for Xbox 360. It is the sequel to "Fable" and "", it was originally announced in 2006 and released in October 2008. A compilation of the game, and its two downloadable content packs, was released on 24 October 2009, titled the "Game of the Year" edition., Michael Fassbender (born 2 April 1977) is an Irish-German actor., Windows Mobile is a family of mobile operating systems developed by Microsoft for smartphones and Pocket PCs., Microsoft Windows (or simply Windows) is a metafamily of graphical operating systems developed, marketed, and sold by Microsoft. It consists of several families of operating systems, each of which cater to a certain sector of the computing industry with the OS typically associated with IBM PC compatible architecture. Active Windows families include Windows NT, Windows Embedded and Windows Phone; these may encompass subfamilies, e.g. Windows Embedded Compact (Windows CE) or Windows Server. Defunct Windows families include Windows 9x; Windows 10 Mobile is an active product, unrelated to the defunct family Windows Mobile., Windows NT is a family of operating systems produced by Microsoft, the first version of which was released in July 1993. It is a processor-independent, multiprocessing, multi-user operating system., Naomie Melanie Harris, OBE (born 6 September 1976) is an English actress. She started her career as a child actress, appearing on the children television series "Simon and the Witch" in 1987. She played voodoo witch Tia Dalma in the second and third "Pirates of the Caribbean" films, Selena in "28 Days Later", and Winnie Mandela in "". She played Eve Moneypenny in the James Bond films "Skyfall" and "Spectre". In 2016, she starred in the critically acclaimed film "Moonlight", a performance which earned her nominations for several awards including the Golden Globe, BAFTA, and Academy Award for Best Supporting Actress., Fable III is the third video game in the Fable series of action role - playing open world video games . The game was published by Microsoft Game Studios and developed by Lionhead Studios for the Xbox 360 and Microsoft Windows . The story focuses on the player character 's struggle to overthrow the King of Albion ( who is the hero 's brother ) by forming alliances and building support for a revolution . After a successful revolt , the player becomes the monarch and is tasked with attempting to defend Albion from a great evil . The game includes voice acting by Ben Kingsley ( Sabine ) , Stephen Fry ( Reaver ) , Simon Pegg ( Ben Finn ) , Naomie Harris ( Page ) , Michael Fassbender ( Logan ) , Zoë Wanamaker ( Theresa ) , Bernard Hill ( Sir Walter Beck ) , Nicholas Hoult ( Elliot ) , John Cleese ( Jasper ) , Kellie Bright ( Hero of Brightwall female ) , and Louis Tamone ( Hero of Brightwall male ) . The game was released on 29 October 2010 for Xbox 360 and on 20 May 2011 for PC via both Games for Windows and Steam . The PC version includes a Hardcore mode and 3D functionality not found in the Xbox 360 version . Since 2013 , the PC version is no longer available for download through either venue ., Simon and the Witch is a children's book by Margaret Stuart Barry, published by Collins, illustrated by Linda Birch. It also refers to the name of the series, which follows on. Simon is a very sensible young schoolboy, who has a friend who is a real witch. She is very silly, and a huge showoff., BBC One is the flagship television channel of the British Broadcasting Corporation in the United Kingdom, Isle of Man and Channel Islands. It was launched on 2 November 1936 as the BBC Television Service, and was the world's first regular television service with a high level of image resolution. It was renamed BBC TV in 1960, using this name until the launch of sister channel BBC2 in 1964, whereupon the BBC TV channel became known as BBC1, with the current spelling adopted in 1997., Stephen John Fry (born 24 August 1957) is an English comedian, actor, writer, presenter, and activist. After a troubled childhood and adolescence, during which he was expelled from two schools and spent three months in prison for credit card fraud, Fry secured a place at Queens' College, Cambridge, where he studied English literature. While at university, he became involved with the Cambridge Footlights, where he met his long-time collaborator Hugh Laurie. As half of the comic double act Fry and Laurie, he co-wrote and co-starred in "A Bit of Fry & Laurie" and also took the role of Jeeves (with Laurie playing Wooster) in "Jeeves and Wooster"., James Hugh Calum Laurie (born 11 June 1959), is an English actor, writer, director, musician, singer and comedian. He first became known as one-half of the Fry and Laurie double act with his friend and comedy partner Stephen Fry, whom he joined in the cast of "A Bit of Fry & Laurie", "Blackadder", and "Jeeves and Wooster" in the 1980s and 1990s., Abandoning previous ventures in favor of toys in the 1960s, Nintendo then developed into a video game company in the 1970s, ultimately becoming one of the most influential in the industry and Japan's third most-valuable company with a market value of over $85 billion. From 1992 until 2016, Nintendo was also the majority shareholder of Major League Baseball's Seattle Mariners., Edinburgh is the capital city of Scotland and one of its 32 local government council areas. Located in Lothian on the Firth of Forth's southern shore, it is Scotland's second most populous city and the seventh most populous in the United Kingdom. The 2014 official population estimates are 464,990 for the city of Edinburgh, 492,680 for the local authority area, and 1,339,380 for the city region as of 2014 (Edinburgh lies at the heart of the proposed Edinburgh and South East Scotland city region). Recognised as the capital of Scotland since at least the 15th century, Edinburgh is home to the Scottish Parliament and the seat of the monarchy in Scotland. The city is also the annual venue of the General Assembly of the Church of Scotland and home to national institutions such as the National Museum of Scotland, the National Library of Scotland and the Scottish National Gallery. It is the largest financial centre in the UK after London., The original console in the series was the first video game console to ship 100 million units, 9 years and 6 months after its initial launch. Its successor, the PlayStation 2, was released in 2000. The PlayStation 2 is the best-selling home console to date, having reached over 155 million units sold as of December 28, 2012. Sony's next console, the PlayStation 3, was released in 2006 and has sold over 80 million consoles worldwide as of November 2013. Sony's latest console, the PlayStation 4, was released in 2013, selling 1 million consoles in its first 24 hours on sale, becoming the fastest selling console in history., The Wii is a home video game console released by Nintendo on November 19, 2006. As a seventh-generation console, the Wii competed with Microsoft's Xbox 360 and Sony's PlayStation 3. Nintendo states that its console targets a broader demographic than that of the two others. , the Wii leads its generation over PlayStation 3 and Xbox 360 in worldwide sales, with more than 101 million units sold; in December 2009, the console broke the sales record for a single month in the United States., Windows Server is a brand name for a group of server operating systems released by Microsoft. It includes all Windows operating systems branded "Windows Server", but not any other Microsoft product. The first Windows server edition to be released under that brand was Windows Server 2003. However, the first server edition of Windows was Windows NT 3.1 Advanced Server, followed by Windows NT 3.5 Server, Windows NT 4.0 Server, and Windows 2000 Server; the latter was the first server edition to include Active Directory, DNS Server, DHCP Server, Group Policy, as well as many other popular features used today., Queens' College is a constituent college of the University of Cambridge, England. Queens' is one of the oldest and largest colleges of the university, founded in 1448 by Margaret of Anjou (the Queen of Henry VI, who founded King's College), and has some of the most recognisable buildings in Cambridge. The college spans both sides of the river Cam, colloquially referred to as the "light side" and the "dark side", with the world-famous Mathematical Bridge connecting the two., Subject: fable iii, Relation: publisher, Options: (A) 22cans (B) actor (C) avon (D) bbc (E) century (F) electronic arts (G) english (H) fourth estate (I) ibm (J) lionhead studios (K) microsoft (L) microsoft studios (M) microsoft windows (N) mtv (O) national museum (P) newcastle upon tyne (Q) nintendo (R) north america (S) pocket (T) samsung (U) sentinel (V) sony (W) sony computer entertainment (X) square (Y) star trek (Z) stuart ([) the academy (\) university of cambridge
[A]: microsoft studios


[Q]: Context: Megacolon is an abnormal dilation of the colon (also called the large intestine). The dilation is often accompanied by a paralysis of the peristaltic movements of the bowel. In more extreme cases, the feces consolidate into hard masses inside the colon, called fecalomas (literally, "fecal tumor"), which can require surgery to be removed., An abscess is a collection of pus that has built up within the tissue of the body. Signs and symptoms of abscesses include redness, pain, warmth, and swelling. The swelling may feel fluid filled when pressed. The area of redness often extends beyond the swelling. Carbuncles and boils are types of abscess that often involve hair follicles with carbuncles being larger.
They are usually caused by a bacterial infection. Often many different types of bacteria are involved in a single infection. In the United States and many other areas of the world the most common bacteria present is "methicillin-resistant Staphylococcus aureus". Rarely, parasites can cause abscesses and this is more common in the developing world. Diagnosis of a skin abscess is usually made based on what it looks like and is confirmed by cutting it open. Ultrasound imaging may be useful in cases in which the diagnosis is not clear. In abscesses around the anus, computer tomography (CT) may be important to look for deeper infection.
Standard treatment for most skin or soft tissue abscesses is cutting it open and drainage. There does not appear to be any benefit from also using antibiotics for this type of abscess in most people who are otherwise healthy. A small amount of evidence supports not packing the cavity that remains with gauze after drainage. Closing this cavity right after draining it rather than leaving it open may speed healing without increasing the risk of the abscess returning. Sucking out the pus with a needle is often not sufficient.
Skin abscesses are common and have become more common in recent years. Risk factors include intravenous drug use with rates reported as high as 65% in this population. In 2005 in the United States 3.2 million people went to the emergency department for an abscess. In Australia around 13,000 people were hospitalized in 2008 with the condition., Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In some types other organs are also affected. Onset can be gradual or sudden.
There are over 100 types of arthritis. The most common forms are osteoarthritis (degenerative joint disease) and rheumatoid arthritis. Osteoarthritis usually occurs with age and affects the fingers, knees, and hips. Rheumatoid arthritis is an autoimmune disorder that often affects the hands and feet. Other types include gout, lupus, fibromyalgia, and septic arthritis. They are all types of rheumatic disease.
Treatment may include resting the joint and alternating between applying ice and heat. Weight loss and exercise may also be useful. Pain medications such as ibuprofen and paracetamol (acetaminophen) may be used. In some a joint replacement may be useful.
Osteoarthritis affects more than 3.8% of people while rheumatoid arthritis affects about 0.24% of people. Gout affects about 1 to 2% of the Western population at some point in their lives. In Australia about 15% of people are affected, while in the United States more than 20% of have a type of arthritis. Overall the disease becomes more common with age. Arthritis is a common reason that people miss work and can result in a decreased quality of life. The term is from Greek "arthro-" meaning joint and "-itis" meaning inflammation., Medical imaging is the technique and process of creating visual representations of the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organs and tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging., Reactive arthritis is a form of inflammatory arthritis that develops in response to an infection in another part of the body (cross-reactivity). Coming into contact with bacteria and developing an infection can trigger the disease. By the time the patient presents with symptoms, often the "trigger" infection has been cured or is in remission in chronic cases, thus making determination of the initial cause difficult., Bowel obstruction, also known as intestinal obstruction, is a mechanical or functional obstruction of the intestines which prevents the normal movement of the products of digestion. Either the small bowel or large bowel may be affected. Symptoms include abdominal pain, vomiting, bloating, and not passing gas. Mechanical obstruction is the cause of about 5 to 15% of cases of severe abdominal pain of sudden onset requiring admission to hospital.
Causes of bowel obstruction include adhesions, hernias, volvulus, endometriosis, inflammatory bowel disease, appendicitis, tumors, diverticulitis, ischemic bowel, tuberculosis, and intussusception. Small bowel obstructions are most often due to adhesions and hernias while large bowel obstructions are most often due to tumors and volvulus. The diagnosis may be made on plain X-rays; however, CT scan is more accurate. Ultrasound or MRI may help in the diagnosis of children or pregnant women.
The condition may be treated conservatively or with surgery. Typically intravenous fluids are given, a tube is placed through the nose into the stomach to decompress the intestines, and pain medications are given. Antibiotics are often given. In small bowel obstruction about 25% require surgery. Complications may include sepsis, bowel ischemia, and bowel perforation.
About 2.5 million cases of or bowel obstruction occurred in 2013 which resulted in 236,000 deaths. Both sexes are equally affected and the condition can occur at any age. Bowel obstruction has been documented throughout history with cases detailed in the Ebers Papyrus of 1550 BC and by Hippocrates., Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. Most cases of immunodeficiency are acquired ("secondary") due to extrinsic factors that affect the patient's immune system. Examples of these extrinsic factors include HIV infection, extremes of age, and environmental factors, such as nutrition. In the clinical setting, the immunosuppression by some drugs, such as steroids, can be either an adverse effect or the intended purpose of the treatment. Examples of such use is in organ transplant surgery as an anti-rejection measure and in patients suffering from an overactive immune system, as in autoimmune diseases. Some people are born with intrinsic defects in their immune system, or primary immunodeficiency. A person who has an immunodeficiency of any kind is said to be immunocompromised. An immunocompromised person may be particularly vulnerable to opportunistic infections, in addition to normal infections that could affect everyone. Immunodeficiency also decreases cancer immunosurveillance, in which the immune system scans the body's cells and kills neoplastic ones., Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. The disease may also affect other parts of the body. This may result in a low red blood cell count, inflammation around the lungs, and inflammation around the heart. Fever and low energy may also be present. Often, symptoms come on gradually over weeks to months.
While the cause of rheumatoid arthritis is not clear, it is believed to involve a combination of genetic and environmental factors. The underlying mechanism involves the body's immune system attacking the joints. This results in inflammation and thickening of the joint capsule. It also affects the underlying bone and cartilage. The diagnosis is made mostly on the basis of a person's signs and symptoms. X-rays and laboratory testing may support a diagnosis or exclude other diseases with similar symptoms. Other diseases that may present similarly include systemic lupus erythematosus, psoriatic arthritis, and fibromyalgia among others.
The goal of treatment is to reduce pain, decrease inflammation, and improve a person's overall functioning. This may be helped by balancing rest and exercise, the use of splints and braces, or the use of assistive devices. Pain medications, steroids, and NSAIDs are frequently used to help with symptoms. A group of medications called disease-modifying antirheumatic drugs (DMARDs), such as hydroxychloroquine and methotrexate, may be used to try to slow the progression of disease. Biological DMARDs may be used when disease does not respond to other treatments. However, they may have a greater rate of adverse effects. Surgery to repair, replace, or fuse joints may help in certain situations. Most alternative medicine treatments are not supported by evidence.
RA affects between 0.5 and 1% of adults in the developed world with between 5 and 50 per 100,000 people newly developing the condition each year. Onset is most frequent during middle age and women are affected 2.5 times as frequently as men. In 2013, it resulted in 38,000 deaths up from 28,000 deaths in 1990. The first recognized description of RA was made in 1800 by Dr. Augustin Jacob Landré-Beauvais (17721840) of Paris. The term "rheumatoid arthritis" is based on the Greek for watery and inflamed joints.
Signs and symptoms.
RA primarily affects joints, but it also affects other organs in more than 1525% of individuals., Diarrhea, also spelled diarrhoea, is the condition of having at least three loose or liquid bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin with loss of the normal stretchiness of the skin and irritable behaviour. This can progress to decreased urination, loss of skin color, a fast heart rate, and a decrease in responsiveness as it becomes more severe. Loose but non-watery stools in babies who are breastfed, however, may be normal.
The most common cause is an infection of the intestines due to either a virus, bacteria, or parasite; a condition known as gastroenteritis. These infections are often acquired from food or water that has been contaminated by stool, or directly from another person who is infected. It may be divided into three types: short duration watery diarrhea, short duration bloody diarrhea, and if it lasts for more than two weeks, persistent diarrhea. The short duration watery diarrhea may be due to an infection by cholera, although this is rare in the developed world. If blood is present it is also known as dysentery. A number of non-infectious causes may also result in diarrhea, including hyperthyroidism, lactose intolerance, inflammatory bowel disease, a number of medications, and irritable bowel syndrome. In most cases, stool cultures are not required to confirm the exact cause.
Prevention of infectious diarrhea is by improved sanitation, clean drinking water, and hand washing with soap. Breastfeeding for at least six months is also recommended as is vaccination against rotavirus. Oral rehydration solution (ORS), which is clean water with modest amounts of salts and sugar, is the treatment of choice. Zinc tablets are also recommended. These treatments have been estimated to have saved 50 million children in the past 25 years. When people have diarrhea it is recommended that they continue to eat healthy food and babies continue to be breastfed. If commercial ORS are not available, homemade solutions may be used. In those with severe dehydration, intravenous fluids may be required. Most cases; however, can be managed well with fluids by mouth. Antibiotics, while rarely used, may be recommended in a few cases such as those who have bloody diarrhea and a high fever, those with severe diarrhea following travelling, and those who grow specific bacteria or parasites in their stool. Loperamide may help decrease the number of bowel movements but is not recommended in those with severe disease.
About 1.7 to 5 billion cases of diarrhea occur per year. It is most common in developing countries, where young children get diarrhea on average three times a year. Total deaths from diarrhea are estimated at 1.26 million in 2013  down from 2.58 million in 1990. In 2012, it was the second most common cause of deaths in children younger than five (0.76 million or 11%). Frequent episodes of diarrhea are also a common cause of malnutrition and the most common cause in those younger than five years of age. Other long term problems that can result include stunted growth and poor intellectual development., Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any part of the gastrointestinal tract from mouth to anus. Signs and symptoms often include abdominal pain, diarrhea (which may be bloody if inflammation is severe), fever, and weight loss. Other complications may occur outside the gastrointestinal tract and include anemia, skin rashes, arthritis, inflammation of the eye, and feeling tired. The skin rashes may be due to infections as well as pyoderma gangrenosum or erythema nodosum. Bowel obstruction also commonly occurs and those with the disease are at greater risk of bowel cancer.
Crohn's disease is caused by a combination of environmental, immune and bacterial factors in genetically susceptible individuals. It results in a chronic inflammatory disorder, in which the body's immune system attacks the gastrointestinal tract possibly directed at microbial antigens. While Crohn's is an immune related disease, it does not appear to be an autoimmune disease (in that the immune system is not being triggered by the body itself). The exact underlying immune problem is not clear; however, it may be an immunodeficiency state. About half of the overall risk is related to genetics with more than 70 genes found to be involved. Tobacco smokers are two times more likely to develop Crohn's disease than nonsmokers. It also often begins after gastroenteritis. Diagnosis is based on a number of findings including biopsy and appearance of the bowel wall, medical imaging and description of the disease. Other conditions that can present similarly include irritable bowel syndrome and Behçet's disease.
There are no medications or surgical procedures that can cure Crohn's disease. Treatment options help with symptoms, maintain remission, and prevent relapse. In those newly diagnosed, a corticosteroid may be used for a brief period of time to quickly improve the disease with another medication such as either methotrexate or a thiopurine used to prevent recurrence. An important part of treatment is the stopping of smoking among those who do. One in five people with the disease are admitted to hospital each year, and half of those with the disease will require surgery for the disease at some point over a ten-year period. While surgery should be used as little as possible, it is necessary to address some abscesses, certain bowel obstructions, and cancers. Checking for bowel cancer via colonoscopy is recommended every few years, starting eight years after the disease has begun.
Crohn's disease affects about 3.2 per 1,000 people in Europe and North America. It is less common in Asia and Africa. It has historically been more common in the developed world. Rates have, however, been increasing, particularly in the developing world, since the 1970s. Inflammatory bowel disease resulted in 35,000 deaths in 2010 and those with Crohn's disease have a slightly reduced life expectancy. It tends to start in the teens and twenties, although it can occur at any age. Males and females are equally affected. The disease was named after gastroenterologist Burrill Bernard Crohn, who, in 1932, together with two other colleagues at Mount Sinai Hospital in New York, described a series of patients with inflammation of the terminal ileum of the small intestine, the area most commonly affected by the illness., Irritable bowel syndrome (IBS) is a group of symptomsincluding abdominal pain and changes in the pattern of bowel movements without any evidence of underlying damage. These symptoms occur over a long time, often years. It has been classified into four main types depending on if diarrhea is common, constipation is common, both are common, or neither occurs very often (IBS-D, IBS-C, IBS-M, or IBS-U respectively). IBS negatively affects quality of life and may result in missed school or work. Disorders such as anxiety, major depression, and chronic fatigue syndrome are common among people with IBS.
The causes of IBS are not clear. Theories include gutbrain axis problems, small intestinal bacterial overgrowth, genetic factors, food sensitivity, and gut motility problems. Onset may be triggered by an intestinal infection, or stressful life event. IBS is a functional gastrointestinal disorder. Diagnosis is based on signs and symptoms in the absence of worrisome features. Worrisome features include onset at greater than 50 years of age, weight loss, blood in the stool, or a family history of inflammatory bowel disease. Other conditions that may present similarly include celiac disease, microscopic colitis, inflammatory bowel disease, bile acid malabsorption, and colon cancer.
There is no cure for IBS. Treatment is carried out to improve symptoms. This may including dietary changes, medication, probiotics, and counseling. Dietary measures include increasing soluble fiber intake, a gluten free diet, or a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP). The medication loperamide may be used to help with diarrhea while laxatives may be used to help with constipation. Antidepressants may improve overall symptoms and pain. Patient education and a good doctorpatient relationship are an important part of care.
About 10 to 15% of people in the developed world are believed to be affected by IBS. It is more common in South America and less common in Southeast Asia. It is twice as common in women as men and typically occurs before age 45. The condition appears to become less common with age. IBS does not affect life expectancy or lead to other serious diseases. The first description of the condition was in 1820 while the current term "irritable bowel syndrome" came into use in 1944.
Classification.
IBS can be classified as either diarrhea-predominant (IBS-D), constipation-predominant (IBS-C), or with alternating stool pattern (IBS-A) or pain-predominant. In some individuals, IBS may have an acute onset and develop after an infectious illness characterized by two or more of: fever, vomiting, diarrhea, or positive stool culture. This postinfective syndrome has consequently been termed "postinfectious IBS" (IBS-PI)., Infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to these organisms and the toxins they produce. Infectious disease, also known as transmissible disease or communicable disease, is illness resulting from an infection.
Infections are caused by infectious agents including viruses, viroids, prions, bacteria, nematodes such as parasitic roundworms and pinworms, arthropods such as ticks, mites, fleas, and lice, fungi such as ringworm, and other macroparasites such as tapeworms and other helminths., In medicine , sacroiliitis is an inflammation of the sacroiliac joint . Sacroiliitis is a feature of spondylarthropathies , such as ankylosing spondylitis , psoriatic arthritis , reactive arthritis or arthritis related to inflammatory bowel diseases , including ulcerative colitis or Crohn 's disease . It is also the most common presentation of arthritis from Brucellosis ., Septic arthritis, also known as infectious arthritis or joint infection, is the purulent invasion of a joint by an infectious agent which produces arthritis. People with artificial joints are more at risk than the general population but have slightly different symptoms, are infected with different organisms and require different treatment. Septic arthritis is considered a medical emergency. If untreated, it may destroy the joint in a period of days. The infection may also spread to other parts of the body., Surgery (from the "cheirourgik" (composed of , "hand", and , "work"), via , meaning "hand work") is an ancient medical specialty that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance or to repair unwanted ruptured areas (for example, a perforated ear drum)., Osteoarthritis (OA) is a type of joint disease that results from breakdown of joint cartilage and underlying bone. The most common symptoms are joint pain and stiffness. Initially, symptoms may occur only following exercise, but over time may become constant. Other symptoms may include joint swelling, decreased range of motion, and when the back is affected weakness or numbness of the arms and legs. The most commonly involved joints are those near the ends of the fingers, at the base of the thumb, neck, lower back, knee, and hips. Joints on one side of the body are often more affected than those on the other. Usually the symptoms come on over years. It can affect work and normal daily activities. Unlike other types of arthritis, only the joints are typically affected.
Causes include previous joint injury, abnormal joint or limb development, and inherited factors. Risk is greater in those who are overweight, have one leg of a different length, and have jobs that result in high levels of joint stress. Osteoarthritis is believed to be caused by mechanical stress on the joint and low grade inflammatory processes. It develops as cartilage is lost and the underlying bone becomes affected. As pain may make it difficult to exercise, muscle loss may occur. Diagnosis is typically based on signs and symptoms, with medical imaging and other tests occasionally used to either support or rule out other problems. In contrast to rheumatoid arthritis, which is primarily an inflammatory condition, in osteoarthritis, the joints do not typically become hot or red.
Treatment includes exercise, efforts to decrease joint stress, support groups, and pain medications. Efforts to decrease joint stress include resting and the use of a cane. Weight loss may help in those who are overweight. Pain medications may include paracetamol (acetaminophen) as well as NSAIDs such as naproxen or ibuprofen. Long-term opioid use is generally discouraged due to lack of information on benefits as well as risks of addiction and other side effects. If pain interferes with normal life despite other treatments, joint replacement surgery may help. An artificial joint typically lasts 10 to 15 years.
Osteoarthritis is the most common form of arthritis with disease of the knee and hip affecting about 3.8% of people as of 2010. Among those over 60 years old, about 10% of males and 18% of females are affected. It is the cause of about 2% of years lived with disability. In Australia, about 1.9 million people are affected, and in the United States, 30 to 52.5 million people are affected. It becomes more common in both sexes as people become older., Genetics is the study of genes, genetic variation, and heredity in living organisms. It is generally considered a field of biology, but intersects frequently with many other life sciences and is strongly linked with the study of information systems., Replacement arthroplasty (from Greek "arthron", joint, limb, articulate, + "plassein", to form, mould, forge, feign, make an image of), or joint replacement surgery, is a procedure of orthopedic surgery in which an arthritic or dysfunctional joint surface is replaced with an orthopedic prosthesis. Joint replacement is considered as a treatment when severe joint pain or dysfunction is not alleviated by less-invasive therapies. During the latter half of the 20th century, rheumasurgery developed as a subspecialty focused on these and a few other procedures in patients with rheumatic diseases., Burrill Bernard Crohn (June 13, 1884  July 29, 1983) was an American gastroenterologist and made the first major advance to identify the disease that now bears his name. Although the description of Crohn's disease is by far his most famous accomplishment, Crohn had a long career both as a clinician, and as a researcher who contributed to modern understanding of many gastrointestinal conditions.
Life and work.
Crohn received his bachelor's degree from City College of New York in 1902. He received a medical degree from Columbia University College of Physicians and Surgeons in 1907. Crohn first became an intern at Mount Sinai Hospital in 1907. He was promoted to head of gastroenterology in 1920, the same year he joined the staff of Columbia University., Fibromyalgia (FM) is a medical condition characterised by chronic widespread pain and a heightened pain response to pressure. Other symptoms include feeling tired to a degree that normal activities are affected, sleep problems, and troubles with memory. Some people also report restless legs syndrome, bowel or bladder problems, numbness and tingling, and sensitivity to noise, lights or temperature. Fibromyalgia is frequently associated with depression, anxiety, and posttraumatic stress disorder. Other types of chronic pain are also frequently present.
The cause of fibromyalgia is unknown; however, it is believed to involve a combination of genetic and environmental factors with half the risk attributed to each. The condition runs in families and many genes are believed to be involved. Environmental factors may include psychological stress, trauma, and certain infections. The pain appears to result from processes in the central nervous system and the condition is referred to as a "central sensitization syndrome". Fibromyalgia is recognized as a disorder by the US National Institutes of Health and the American College of Rheumatology. There is no specific diagnostic test. Diagnosis involves first ruling out other potential causes and verifying that a set number of symptoms are present.
The treatment of fibromyalgia can be difficult. Recommendations often include getting enough sleep, exercising regularly, and eating a healthy diet. Cognitive behavioral therapy may also be helpful. The medications duloxetine, milnacipran, or pregabalin may be used. Use of opioid pain medication is controversial with some stating their use is poorly supported by evidence and others saying that weak opioids may be reasonable if other medications are not effective. Dietary supplements also lack evidence to support their use. While fibromyalgia can last a long time, it does not result in death or tissue damage.
Fibromyalgia is estimated to affect 28% of the population. Females are affected about twice as often as males. Rates appear similar in different areas of the world and among different cultures. Fibromyalgia was first defined in 1990 with updated criteria in 2011. There is controversy about the classification, diagnosis, and treatment of fibromyalgia. While some feel the diagnosis of fibromyalgia may negatively affect a person, other research finds it to be beneficial. The term "fibromyalgia" is from New Latin, "fibro-", meaning "fibrous tissues", Greek  "myo-", "muscle", and Greek  "algos", "pain"; thus the term literally means "muscle and fibrous connective tissue pain"., Ankylosing spondylitis (AS) is a type of arthritis in which there is long term inflammation of the joints of the spine. Typically the joints where the spine joins the pelvis are also affected. Occasionally other joints such as the shoulders or hips are involved. Eye and bowel problems may also occur. Back pain is a characteristic symptom of AS, and it often comes and goes. Stiffness of the affected joints generally worsens over time.
The cause of ankylosing spondylitis is unknown; however, it is believed to involve a combination of genetic and environmental factors. More than 90% of those effected have a specific human leukocyte antigen known as the HLA-B27 antigen. The underlying mechanism is believed to be autoimmune or autoinflammatory. Diagnosis is typically based on the symptoms with support from medical imaging and blood tests. AS is a type of seronegative spondyloarthropathy, meaning that tests show no presence of rheumatoid factor (RF) antibodies.
There is no cure for ankylosing spondylitis. Treatments may improve symptoms and prevent worsening. This may include medication, exercise, and surgery. Medications used include NSAIDs, steroids, DMARDs such as sulfasalazine, and biologic agents such as infliximab.
Between 0.1% and 1.8% of people are affected. Onset is typically in young adults. Males are more often affected than females. The condition was first fully described in the late 1600s by Bernard Connor; however, skeletons with ankylosing spondylitis are found in Egyptian mummies. The word is from Greek "ankylos" meaning stiffening, "spondylos" meaning vertebra, and "-itis" meaning inflammation., Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon and rectum. The primary symptom of active disease is abdominal pain and diarrhea mixed with blood. Weight loss, fever, and anemia may also occur. Often symptoms come on slowly and can range from mild to severe. Symptoms typically occur intermittently with periods of no symptoms between flares. Complications may include megacolon, inflammation of the eye, joints, or liver, and colon cancer.
The cause of UC is unknown. Theories involve immune system dysfunction, genetics, changes in the normal gut bacteria, and environmental factors. Rates tend to be higher in the developed world with some proposing this to be the result of less exposure to intestinal infections, or a Western diet and lifestyle. The removal of the appendix at an early age may be protective. Diagnosis is typically by colonoscopy with tissue biopsies. It is a kind of inflammatory bowel disease (IBD) along with Crohn's disease and microscopic colitis.
Dietary changes may improve symptoms. A number of medications are used to treat symptoms and bring about and maintain remission. These include aminosalicylates such as sulfasalazine, steroids, immunosuppressants such as azathioprine, and biological therapy. Removal of the colon by surgery may be necessary if the disease is severe, does not respond to treatment, or if complications such as colon cancer develop. Removal of the colon and rectum can cure the disease.
The first description of ulcerative colitis occurred around the 1850s. Each year it newly occurs in 1 to 20 people per 100,000 and 5 to 500 per 100,000 individuals are affected. The disease is more common in North America and Europe. Often it begins between 15 and 30 years of age or among those over 60. Males and females appear to be affected equally. It has also become more common since the 1950s. Together, ulcerative colitis and Crohn's disease affect approximately 500,000 to 2 million people in the United States. With appropriate treatment the risk of death appears the same as that of the general population., Subject: sacroiliitis, Relation: medical_specialty, Options: (A) gastroenterology (B) genetics (C) infection (D) infectious disease (E) pathology (F) rheumatology (G) surgery
[A]:
rheumatology