Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Example Input: This procedure appears to be a simple, safe, and effective method for closure of a small conjunctival break.
Example Output: non-adverse drug event

Example Input: Hemoglobin electrophoresis and methemoglobin reductase determinations were normal for age.
Example Output: non-adverse drug event

Example Input: Recognizing early signs of HMSN, such as areflexia and pes cavus deformity, can prevent severe neurotoxicity of polychemotherapy by avoiding vincristine.
Example Output:
adverse drug event