TASK DEFINITION: In this task, you are given a sentence in the Spanish language. Your task is to translate the Spanish sentence into the English language.
PROBLEM: Mediante el Real Decreto 450/2005, de 22 de abril, se regulan

SOLUTION: Royal Decree 450/2005, of April 22, regulates

PROBLEM: ¿Qué caracteriza al proceso de envejecimiento fisiológico del sistema musculoesquelético?

SOLUTION: What characterizes the physiological aging process of the musculoskeletal system?

PROBLEM: ¿Cuál de las siguientes características farmacocinéticas de la rosiglitazona NO es correcta?

SOLUTION:
Which of the following pharmacokinetic characteristics of rosiglitazone is NOT correct ?