instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: Brink (Sir Cedric Hardwicke) has recently taken Pud's (Bobs Watson) parents in an auto wreck. Brink later comes for Gramps (Lionel Barrymore). Believing Brink to be an ordinary stranger, the crotchety old Gramps orders Mr. Brink off the property. Pud comes out of the house and asks who the stranger was. Gramps is surprised and relieved that someone else could see the stranger; he was not merely a dream or apparition. Pud tells Gramps that when he does a good deed, he will be able to make a wish. Because his apples are constantly being stolen, Gramps wishes that anyone who climbs up his apple tree will have to stay there until he permits them to climb down. Pud inadvertently tests the wish when he has trouble coming down from the tree himself, becoming free only when Gramps says he can. Pud's busybody Aunt Demetria (Eily Malyon) has designs on Pud and the money left him by his parents. Gramps spends much time fending off her efforts to adopt the boy. Brink takes Granny Nellie (Beulah Bondi) in a peaceful death just after she finishes a bit of knitting. When Mr. Brink returns again for Gramps, the old man finally realizes who his visitor is. Determined not to leave Pud to Demetria, Gramps tricks Mr. Brink into climbing the apple tree. While stuck in the tree, he cannot take Gramps or anyone else. The only way anyone or anything can die is if they touch Mr. Brink or the apple tree. Demetria plots to have Gramps committed to a psychiatric hospital when he claims that Death is trapped in his apple tree. Gramps proves his story first by proving that his doctor, Dr. Evans (Henry Travers), can not even kill a fly they have captured. He offers further proof of his power by shooting Mr. Grimes (Nat Pendleton), the orderly who has come to take him to the asylum; Grimes lives when he should have died. Dr. Evans is now a believer, but he tries to convince Gramps to let Death down so people who are suffering can find release. Gramps refuses, so the doctor arranges for the local sheriff to commit Gramps while Pud is delivered to Demetria's custody. With the help of his housekeeper (Una Merkel), Gramps tricks both of them into believing they are scheduled to go with Mr. Brink when he comes down from the tree. They beg Gramps to convince Brink otherwise, and Demetria vows never to bother Gramps or Pud again. Gramps realizes that sooner or later he will have to let Brinks downDeath is an ultimately unavoidable part of life. He tries to say goodbye to Pud, who reacts angrily and tries to run away. Mr. Brink sees Pud in the yard and dares him to climb the tree. Pud gets over the fence Gramps has had built around the tree, but falls and is crippled for life. Distraught, Gramps lets Death down from the tree. He takes both Gramps and Pud, who find they can walk again. In the final scene, they walk together up a beautiful country lane and hear Granny Nellie calling to them from beyond a brilliant light. 
 Question: What does Gramps trick Mr. Brink into doing?
answer:
climbing the apple tree


question:
Context: Baghdad, in 2004, three soldiers of an Army bomb-disposal unit are investigating a report of an improvised explosive device (IED). They use a sophisticated robot drone to examine the device, which consists of several undetonated artillery shells wired together and hidden under plastic/fabric sheets. The unit, led by Sgt. Thompson, decides that they can detonate the IED using plastic explosives that they'll activate from a safe distance. Thompson also says that the explosion won't cause very much property damage and should result in no loss of life.A small cart is affixed to the back of the robot, which is then sent back into the blast zone. Before it can reach the IED, the trailer loses a wheel. Thompson dresses in a bulky bomb suit and walks down to the trailer. He picks it up and carries it to the IED, rigging it properly. As he walks back, his partners, Sgt. Sanborn and Specialist Eldridge, scan the immediate area for anyone they consider suspicious or who may be in the blast zone. When Thompson is about 25 meters from the bomb, but still in the kill zone, Eldridge notices a man running a butcher shop who is using a cellular phone. Eldridge yells to Sanborn and the specialist begins to run toward the man, ordering him to drop his phone. Sanborn tells Eldridge to shoot the man, who presses a sequence of numbers on the phone. The bomb detonates with Thompson still in the kill zone. The overpressure from the bomb kills Thompson despite the bomb suit; a large splash of blood hits the inside of the clear visor on his helmet.Thompson's body is packed into a coffin for shipment home, Sanborn supervises the procedure. He looks over Thompson's possessions for a few moments before the coffin is sealed. Back at the base, Eldridge is sitting in the rec room when the base psychologist, Lt. Col. Cambridge walks in and asks Eldridge how he's feeling (in the wake of Thompson's death). Eldridge is still clearly upset over the incident; he dry fires his rifle several times, suggesting that if he'd shot the man with the cell phone, Thompson might still be alive.A new leader for the team, Sgt. William James, arrives at the base. Sanborn meets him at his housing unit, where James is taking the plywood covers off his windows. When Sanborn suggests that James keep them on because of mortar shrapnel, James tells him that they won't be any good anyway if a mortar shell crashes in through the unit's roof.The next day the team responds to a report of another IED on a narrow street in the city. After the initial investigation, where they link up with the Army platoon that reported the bomb, James is dressed up in a suit similar to the one Thompson wore previously. As James approaches the bomb site, he tosses a smoke grenade, which agitates Sanborn, who can't see James to instruct him further. James also is uncommunicative with his team members, another factor that Sanborn does not appreciate. James finds an artillery shell buried under a small pile of trash. He disarms it easily, and then notices a secondary wire leading away from it. He uncovers the cable and finds it connects to a junction of six more cables. When James pulls on the junction connector, six more shells are uncovered. Another cable leads to a nearby building. James disarms the six new shells; as he does, he notices a man quickly leaving the building, presumably the bomber. James flashes one of the small detonators from one of the shells and smiles at the man, who vanishes from sight. Back at their Humvee, Sanborn tells James that he needs to communicate more during operations and not treat his duty as if it's a solo act. James brushes his teammate off. James does the same later when he and Sanborn talk while grooming themselves for another day's work in the latrine.The team is again called out for another bomb threat. This time, the bomb is in a car parked in front of a United Nations building. When the building is evacuated, James dons 
 Question: Who plays Connie?
answer:
james


question:
Context: Osteoporosis is characterised by a progressive loss of bone mass and microarchitecture which leads to increased fracture risk. Some of the drugs available to date have shown reductions in vertebral and non-vertebral fracture risk. However, in the ageing population of industrialised countries, still more fractures happen today than are avoided, which highlights the large medical need for new treatment options, models, and strategies. Recent insights into bone biology, have led to a better understanding of bone cell functions and crosstalk between osteoblasts, osteoclasts, and osteocytes at the molecular level. In the future, the armamentarium against osteoporotic fractures will likely be enriched by (1.) new bone anabolic substances such as antibodies directed against the endogenous inhibitors of bone formation sclerostin and dickkopf-1, PTH and PTHrp analogues, and possibly calcilytics; (2.) new inhibitors of bone resorption such as cathepsin K inhibitors which may suppress osteoclast function without impairing osteoclast viability and thus maintain bone formation by preserving the osteoclast-osteoblast crosstalk, and denosumab, an already widely available antibody against RANKL which inhibits osteoclast formation, function, and survival; and (3.) new therapeutic strategies based on an extended understanding of the pathophysiology of osteoporosis which may include sequential therapies with two or more bone active substances aimed at optimising the management of bone capital acquired during adolescence and maintained during adulthood in terms of both quantity and quality. Finally, one of the future challenges will be to identify those patients and patient populations expected to benefit the most from a given drug therapy or regimen. The WHO fracture risk assessment tool FRAX® and improved access to bone mineral density measurements by DXA will play a key role in this regard. 
 Question: To the ligand of which receptors does Denosumab (Prolia) bind?
answer:

rankl