Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

[EX Q]: Bilateral Acanthamoeba keratitis with late recurrence of the infection in a corneal graft: a case report.
[EX A]: non-adverse drug event

[EX Q]: These patients were treated by the continuous administration of an estrogen-progestogen combination for 6 months.
[EX A]: non-adverse drug event

[EX Q]: METHODS: Repeated blood samples were drawn in a patient with severe acyclovir overdose who developed coma and nonoliguric renal failure.
[EX A]:
adverse drug event