Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: A solution is a mixture of two or more substances in which dissolved particles are distributed evenly throughout the solution. The substance that dissolves in a solution is called the solute, and the substance that does the dissolving is called the solvent. The concentration of a solution is the amount of solute in a given amount of solution. A solution with a lot of dissolved solute has a high concentration and is called a concentrated solution. A solution with little dissolved solute has a low concentration and is called a dilute solution. The concentration of a solution represents the percentage of the solution that is the solute. You can calculate the concentration of a solution using this formula: Concentration = Mass (or volume) of Solute Mass (or volume) of Solution 100% For example, if a 100-gram solution of salt water contains 3 grams of salt, then its concentration is: Concentration = 3g 100g 100% = 3% Q: A 1000 mL container of brand A juice drink contains 250 mL of juice and 750 mL of water. A 600 mL container of brand B juice drink contains 200 mL of juice and 400 mL of water. Which brand of juice drink is more concentrated, brand A or brand B? 250 mL 1000 mL 100% = 25% 200 mL 600 mL 100% = 33% A: Concentration(A) = Concentration(B) = You can conclude that brand B is more concentrated. 
 Question: a solution with a small amount of solute for a given amount of solution is called
dilute.

Context: Bazex syndrome, or acrokeratosis paraneoplastica, is a cutaneous paraneoplastic syndrome characterized by psoriasiform lesions associated with, usually, a squamous cell carcinoma of the upper aerodigestive tract. We present a case of Bazex syndrome associated with metastatic cervical squamous cell carcinoma with an unknown primary. The features of the condition are discussed in the light of current knowledge. 
 Question: Name synonym of Acrokeratosis paraneoplastica.
bazex syndrome

Context: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebrovascular disease due to mutations involving loss or gain of a cysteine residue in the NOTCH3 gene. A cluster of mutations around exons 3 and 4 was originally reported. Identification of pathogenic mutation is important for diagnostic confirmation of the disease, however genetic counselling and testing of relatives at risk is critical in mutation carriers. Mutation analysis of the NOTCH3 gene was performed through direct sequencing in 140 patients with clinical suspicion of CADASIL. Patients underwent genetic counselling pre and post testing. The 2-23 exons containing all EGF-like domains were screened. 14 familial forms of the disease have been identified with 14 different causative mutations in exons 2, 3, 4, 5, 7, 10, 14, 19, 20 and 22 of the NOTCH3 gene; no pathogenetic mutations have been identified in exons 6 and 8; several genetic variations both in coding as well as in intronic regions were identified too. Our data confirm the importance of screening the whole EGF-like domains region of NOTCH3 gene for the molecular diagnosis of CADASIL among the Italian population too. Moreover genetic variants different from loss or gain of a cysteine residue are identified and presented. 
 Question: Which amino acid residue appears mutated in most of the cases reported with cadasil syndrome?

cysteine