Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: Riociguat (Adempas(®)), an oral first-in-class soluble guanylate cyclase (sGC) stimulator, is under global development by Bayer Healthcare Pharmaceuticals Inc. for the treatment of adult patients with inoperable or chronic/persistent chronic thromboembolic pulmonary hypertension (CTEPH) and for the treatment of adult patients with pulmonary arterial hypertension (PAH). The drug directly stimulates sGC in a nitric oxide independent manner, thereby increasing the sensitivity of sGC to nitric oxide, leading to increased cyclic guanosine monophosphate generation (a key signalling molecule involved in regulating vascular tone, proliferation, fibrosis and inflammation). Riociguat is the world's first approved pharmacotherapy for CTEPH, with its first global approval in this indication occurring in Canada. It has subsequently been approved in the USA for the treatment of patients with CTEPH and also received its first global approval in patients with PAH in the USA. It is undergoing regulatory review for these indications in Europe and for use in patients with CTEPH in Japan. This article summarizes the milestones in the development of riociguat, leading to its first global approvals in patients with CTEPH and PAH.
[A]: What is generic name of drug Adempas?


[Q]: If you want to become a fluent English speaker you should take some advice: There are four skills in learning English. They are reading, listening, speaking, and writing. The most important thing you must remember is that if you want to improve your speaking and writing skills you should first master the skills of reading and listening. Read as much as you can. But your reading must be active. It means that you must think about the meaning of the sentence, the meanings of the unfamiliar words, etc. There is no need for you to pay much attention to grammars or try to understand all the unfamiliar words you _ , but the fact that you see them for the first time and recognize them whenever you see them, for example in other passages or books, is enough. It would be better to prepare yourself a notebook so you can write down the important words or sentences in it. As for listening, there are two choices: besides reading, you can listen every day for about 30 minutes. You can only pay attention to your reading and become skillful at your reading, then you can catch up on your listening. Since you have lots of inputs in your mind, you can easily guess what the speaker is going to say. This never means that you should not practice listening. For listening you can listen to cartoons or some movies that are specially made for children. Their languages are easy. Or if you are good at listening you can listen to VOA or BBC programs every day. Again the thing to remember is being active in listening and preferably taking some notes. If you follow these pieces of advice, your speaking and writing will improve automatically, and you can be sure that with a little effort they will become perfect.
[A]: According to the author, which should you improve first among the four skills?


[Q]: Tata Prima is a range of heavy trucks produced by Tata Daewoo, a wholly owned subsidiary of Tata Motors of India.
[A]:
By which company, Tata Prima has been manufactured?