Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: Bone, as well as the lung and liver, is among the sites of predilection for cancer metastasis. The bone stores large amounts of growth factors such as insulin-like growth factors and transforming growth factor-b, and provides fertile soil for metastatic cancer cells by continuously releasing these bone-stored growth factors, which are a consequence of osteoclastic bone resorption. Metastatic cancer cells in turn produce osteoclast-stimulating cytokines such as parathyroid hormone-related protein( PTH-rP), prostaglandin E2.(PGE2), and various interleukins(ILs). These cancer-produced osteoclast-stimulating cytokines bind to their cognitive receptors and promote the expression of ligands for the receptor activators of nuclear factor kB (RANKL)in osteoblasts. RANKL then binds to its receptor RANK, expressed in pre-osteoclasts, stimulates mature osteoclast formation, and subsequently, osteoclastic bone resorption. This vicious cycle between metastatic cancer cells and osteoclasts is critical to the development and progression of bone metastases. In addition, it is likely that metastatic cancer cells are influenced by bone environments(or niche)and acquire additional capacities such as an epithelial-mesenchymal transition(EMT), allowing them to be resistant to chemotherapy or apoptosis, to survive in a dormant state, or to aggressively spread to distant organs including lung and liver. Thus, the bone can serve as transit port. Disrupting this cycle by inhibiting osteoclastic bone resorption, antagonizing bone-derived growth factors, and neutralizing RANKL or PTH-rP, should be a promising therapeutic intervention for bone metastases. Bisphosphonates(BP)are specific inhibitors of osteoclasts, and have been shown to significantly reduce skeletal-related events(SRE)associated with bone metastasis. Denosumab is a neutralizing monoclonal antibody to RANKL and has recently been found to inhibit SRE more effectively than BP. Further understanding of the crosstalk communication between metastatic cancer cells and bone at the molecular level should lead us to design novel, more effective and specific treatments for cancer patients with bone metastases.
[EX A]: To the ligand of which receptors does Denosumab (Prolia) bind?

[EX Q]: The movie begins in the year 1967 with a pregnant woman being admitted to a hospital, bleeding from the neck. Paramedics think she was attacked by some type of animal. Doctors perform an emergency C-Section, and her baby (a boy) is born alive just as she dies.Thirty years later a young man named Dennis (Kenny Johnson) is riding in a car with an attractive redhead named Racquel (Traci Lords) heading to an underground nightclub (located, oddly, in a slaughterhouse) somewhere in Los Angeles. After addressing the doorman in Russian, Racquel brings the young man into the club. The man is confused and trying to understand the rules of the club. Some of the regulars indifferently push him aside. Saying he needs a drink, the sprinkler suddenly system activates, raining blood down on everyone inside. It is then that he (and the audience) realizes that everyone in the club is a vampire.Dennis desperately tries to get away and winds up at the feet of a menacing figure in a black-leather trenchcoat. The vampires look on this figure with awe, mumbling the words: "it's the Daywalker!" This is our first look at Blade (Wesley Snipes), the vampire killer.Blade pulls out a shotgun and opens fire on the vampires, who instantly burn to ashes when killed. When the gun is knocked out of his hands by Racquel, Blade uses a set of silver stakes to kill Racquel and more vampires, including the disk jockey. Soon all the vamps are either dead or have fled except for one; a heavyset vamp named Quinn (Donal Logue), whom Blade has apparently run into before. Blade pins Quinn to the wall, and then sets him on fire before confronting the last member in the club (the human man from the beginning). Finding no vampire bite marks on Dennis, Blade lets him live and makes his escape as the police arrive.Quinn is extinguished and taken to the local hospital. A morgue technician examines his blood and shows the results to Dr. Karen Jenson (N'Bushe Wright), who finds a number of irregularities, including abnormally developed jaw muscles. As they are discussing the test results, Quinn springs back to life and bites both doctors. Before he can finish Dr. Jenson, Blade shows up and saves her, cutting off one of Quinn's arms.Blade brings Karen to his hideout and asks for help from his mentor, an elderly man named named Whistler (Kris Kristofferson). Whistler injects Dr. Jenson with a solution of garlic essence and silver nitrate and remarks that she has a 50/50 chance of recovering.Meanwhile, a group of vampires are discussing Blade's latest attack on their members. Apparently this club (and to an extent, Quinn) is the property of a vampire named Deacon Frost (Stephen Dorff). Frost wants the vampires to outright rule the humans and use them as a food source while the others (particularly an older vampire named Dragonetti) prefer to maintain a peaceful co-existance. Dragonetti (Udo Kier) in particular does not like Frost because Frost is not a "pure-blood" (ie: was not born a vampire, merely became one through the bite of another). Frost is also arrogant and his & the actions of his followers draw unnecessary attention to the vampire underworld.The next morning, Jenson awakens and sees Whistler injecting Blade with some type of serum. She tries to run away but Whistler confronts her and tells her that he and Blade are hunting vampires. Karen of course is skeptical, but Whistler goes on to talk about what they use to hunt- explaining that vampires are severely allergic to silver & garlic while also being vulnerable to sunlight (ultraviolet rays in particular). Whistler fuels up Blade's car and gives him a new UV flashlight to use when hunting that night. Whistler also gives Karen a type of "vampire mace" (garlic & silver nitrate in a liquid form).Blade drops Karen off at her apartment and she tries to pack up and get out of town. A police officer, identifying himself as Officer Krieger (Kevin Patrick Walls), arrives and questions her about the events
[EX A]: What are the weapons made out of?

[EX Q]: Although it is now seen as belonging to the Italian Nouvelle Vague, Before the Revolution did not attract large audiences in Italy where it only received lukewarm approval from most of the critics.
[EX A]:
Which place does Before the Revolution exist in?