Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.
adverse drug event

Over the next 15 h she developed progressive hemolysis and methemoglobinemia.
non-adverse drug event

Some cases run a chronic severe course and fail to respond to local and systemic therapy.

non-adverse drug event