In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.

Example Input: Attenuated, live viral vaccines have been extraordinarily successful in protecting against many diseases. The main drawbacks in their development and use have been reliance on an unpredictable method of attenuation and the potential for evolutionary reversion to high virulence. Methods of genetic engineering now provide many safer alternatives to live vaccines, so if live vaccines are to compete with these alternatives in the future, they must either have superior immunogenicity or they must be able to overcome these former disadvantages. Several live vaccine designs that were historically inaccessible are now feasible because of advances in genome synthesis. Some of those methods are addressed here, with an emphasis on whether they enable predictable levels of attenuation and whether they are stable against evolutionary reversion. These new designs overcome many of the former drawbacks and position live vaccines to be competitive with alternatives. Not only do new methods appear to retard evolutionary reversion enough to prevent vaccine-derived epidemics, but it may even be possible to permanently attenuate live vaccines that are transmissible but cannot evolve to higher virulence under prolonged adaptation.
Example Output: Evolutionary reversion of live viral vaccines: Can genetic engineering subdue it?

Example Input: Thread-based microfluidics Point-of-care Cotton Colorimetric Electrochemical A B S T R A C T Over the past decades, researchers have been seeking attractive substrate materials to keep microfluidics improving to outbalance the drawbacks and issues. Cellulose substrates, including thread, paper and hydrogels are alternatives due to their distinct structural and mechanical properties for a number of applications. Thread have gained considerable attention and become promising powerful tool due to its advantages over paper-based systems thus finds numerous applications in the development of diagnostic systems, smart bandages and tissue engineering. To the best of our knowledge, no comprehensive review articles on the topic of thread-based microfluidics have been published and it is of significance for many scientific communities working on Microfluidics, Biosensors and Lab-on-Chip. This review gives an overview of the advances of thread-based microfluidic diagnostic devices in a variety of applications. It begins with an overall introduction of the fabrication followed by an in-depth review on the detection techniques in such devices and various applications with respect to effort and performance to date. A few perspective directions of thread-based microfluidics in its development are also discussed. Thread-based microfluidics are still at an early development stage and further improvements in terms of fabrication, analytical strategies, and function to become low-cost, low-volume and easy-to-use pointof-care (POC) diagnostic devices that can be adapted or commercialized for real world applications.
Example Output: Recent advances in thread-based microfluidics for diagnostic applications

Example Input: Infection control is an essential component of health care. The literature generally suggests that most health professionals' knowledge of infection control principles and standards is poor or, at the very least, inadequate. There is a paucity of research examining paramedic knowledge of infection control principles and standards, particularly in the Australian pre -hospital context. The purpose of this study was to determine paramedic knowledge of standard infection control definitions and principles in an Australian emergency medical system (EMS). A confidential and anonymous mail survey was distributed to all paramedics working in a State-wide Australian ambulance service (n=2274) A total of 1258 surveys were returned -a response rate of 55.3%. Only 46.2% (n=581) of the participants identified the correct components of the 'chain of infection'. Correct identification of the definition of 'nosocomial'was made by 27.9% (n=347) of participants. Less than onefifth (17.2%, n=217) of participants identified 'standards and additional precautions' as the current system of infection control. Less than half (41.6%, n=523) of the sample correctly identified hand washing as the primary infection control strategy to prevent cross-infection. This study suggests knowledge of fundamental principles and standards of infection control among paramedics is poor in this jurisdiction and recommends the introduction of comprehensive in-service education programmes in infection control. Further research is required to investigate if, and how, these results may be realised in practice.
Example Output:
Paramedic knowledge of infection control principles and standards in an Australian emergency medical system (EMS)