Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: Nuclear receptor co-repressor (N-CoR) plays important role in transcriptional control mediated by several tumor suppressor proteins. Recently, we reported a role of misfolded-conformation dependent loss (MCDL) of N-CoR in the activation of oncogenic survival pathway in acute promyelocytic leukemia (APL). Since N-CoR plays important role in cellular homeostasis in various tissues, therefore, we hypothesized that an APL like MCDL of N-CoR might also be involved in other malignancy. Indeed, our initial screening of N-CoR status in various leukemia and solid tumor cells revealed an APL like MCDL of N-CoR in primary and secondary tumor cells derived from non-small cell lung cancer (NSCLC). The NSCLC cell specific N-CoR loss could be blocked by Kaletra, a clinical grade protease inhibitor and by genistein, an inhibitor of N-CoR misfolding previously characterized by us. The misfolded N-CoR presented in NSCLC cells was linked to the amplification of ER stress and was subjected to degradation by NSCLC cell specific aberrant protease activity. In NSCLC cells, misfolded N-CoR was found to be associated with Hsc70, a molecular chaperone involved in chaperone mediated autophagy (CMA). Genetic and chemical inhibition of Lamp2A, a rate limiting factor of CMA, significantly blocked the loss of N-CoR in NSCLC cells, suggesting a crucial role of CMA in N-CoR degradation. These findings identify an important role of CMA-induced degradation of misfolded N-CoR in the neutralization of ER stress and suggest a possible role of misfolded N-CoR protein in the activation of oncogenic survival pathway in NSCLC cells.

Output: Which is the receptor for substrates of Chaperone Mediated Autophagy?


Input: Consider Input: The Men in Black are a secret law-enforcement agency that is responsible for policing the extraterrestrial life hidden on Earth, as well as protecting the world from any aliens who attempt to destroy/invade the planet.The film begins on LunarMax, a MiB prison situated on the moon. A one-armed criminal, a Boglodite named Boris the Animal, stages a jailbreak (along the way killing Obadiah Price, a fellow inmate he'd made a deal with). His intention is to rewrite history, with Agent K, the one who arrested and imprisoned him, being a major factor in his plan...On Earth, Agent K and his partner Agent J cover up an arrival of an alien spacecraft, and hear of the prison break. At a Chinese restaurant thats a local haunt for aliens, Agent K discovers Boris (who had previously gone to see Obadiah's son Jeffrey) and the two fight, with J joining in. K is upset that the alien he should have killed is out loose again; he deems it his own affair and forbids J to help him, suspending him. A puzzled J checks up on Boris: he appeared in 1969 to stop the prevention of the ArcNet Shield, a device that K deployed to protect the world from harm (but which killed off the Boglodites, as they can only survive by feeding off worlds). He managed to kill on 15 July 1969 an alien named Roman the Fabulous and on the following day... at this point O cuts him off and tells him not to investigate any further. That night, as K waits for Boris with a gun in his hand, he suddenly vanishes...The next morning, J discovers that he has a new partner, the liberated Agent AA, and that K has been dead for forty years (having been killed by Boris the Animal on 16th July 1969). O notices he is suffering from headaches and craves chocolate milk, which she explains are symptoms of time-fracture (aka the crime of interfering with history, which Obadiah Price was imprisoned for). At this point a Boglodite armada appears; J learns that there was nothing to hold them at bay, with no K to deploy the ArcNet. He theorizes that Boris went back in time to 1969 to kill K, thus changing history to what it was, and proposes to follow him; he heads to Jeffrey Price, who had provided Boris a time-jump device, and gets another one from him, and activates it by jumping off the Chrysler Building just as the Boglodites begin their assault...J arrives in 15 July 1969, with the intention to catch Boris as he is about to murder Roman the Fabulous. However, he is delayed from navigating the era of 1969 (most notably by an altercation with two racist cops), and gets there too late to stop Romans murder by 1969 Boris. He encounters 1969 Agent K, who subdues him and brings him to MiB headquarters. J tells K nothing, but when threatened with getting his memory erased he tells K part of the truth: he came from the future in pursuit of another time-traveler whos trying to change history.K and J follow a trail of clues to Andy Warhols Factory complex, where Warhol is revealed to be MiB Agent W. He notifies them of Griffin, an Arcanian being who has the ability to foresee all timelines and futures; Griffins planet was destroyed by the Boglodites, so he came to live on Earth and brought with him a device which will prevent the Boglodites from consuming the Earth. 1969 Boris arrives at the Factory in search of Griffin, who makes a quick exit with Boris in fast pursuit (to Js displeasure, although K doesnt seem to get too worried).J and K eventually track down Griffin at Shea Stadium, where he is foreseeing the future victory for the Mets baseball team. 1969 Boris appears and captures Griffin, but J and K are able to rescue Griffin, although Boris gets away. Griffin gives them the ArcNet and explains it can only work in zero gravity: K gets the idea to head to Cape Canaveral on 16th July 1969 (the day the Apollo 11 ship launched)

Output: Who attacks the agents as they climb up the tower?


Input: Consider Input: The centriole and basal body (CBB) structure nucleates cilia and flagella, and is an essential component of the centrosome, underlying eukaryotic microtubule-based motility, cell division and polarity. In recent years, components of the CBB-assembly machinery have been identified, but little is known about their regulation and evolution. Given the diversity of cellular contexts encountered in eukaryotes, but the remarkable conservation of CBB morphology, we asked whether general mechanistic principles could explain CBB assembly. We analysed the distribution of each component of the human CBB-assembly machinery across eukaryotes as a strategy to generate testable hypotheses. We found an evolutionarily cohesive and ancestral module, which we term UNIMOD and is defined by three components (SAS6, SAS4/CPAP and BLD10/CEP135), that correlates with the occurrence of CBBs. Unexpectedly, other players (SAK/PLK4, SPD2/CEP192 and CP110) emerged in a taxon-specific manner. We report that gene duplication plays an important role in the evolution of CBB components and show that, in the case of BLD10/CEP135, this is a source of tissue specificity in CBB and flagella biogenesis. Moreover, we observe extreme protein divergence amongst CBB components and show experimentally that there is loss of cross-species complementation among SAK/PLK4 family members, suggesting species-specific adaptations in CBB assembly. We propose that the UNIMOD theory explains the conservation of CBB architecture and that taxon- and tissue-specific molecular innovations, gained through emergence, duplication and divergence, play important roles in coordinating CBB biogenesis and function in different cellular contexts.


Output: Where in the cell do we find the protein Cep135?