Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: Fafhrd and the Gray Mouser are two sword-and-sorcery heroes appearing in stories written by American author Fritz Leiber.
[A]: Who is the author of Fafhrd and the Gray Mouser?


[Q]: A significant role for IFN in the pathogenesis of systemic lupus erythematosus is well supported, and clinical trials of anti-IFN monoclonal antibodies are in progress in this disease. In other autoimmune diseases characterized by substantial inflammation and tissue destruction, the role of type I interferons is less clear. Gene expression analysis of peripheral blood cells from patients with rheumatoid arthritis and multiple sclerosis demonstrate an interferon signature similar to but less intense than that seen in patients with lupus. In both of those diseases, presence of the interferon signature has been associated with more significant clinical manifestations. At the same time, evidence supports an anti-inflammatory and beneficial role of IFN locally in the joints of patients with rheumatoid arthritis and in murine arthritis models, and many patients with multiple sclerosis show a clinical response to recombinant IFN. As can also be proposed for type I diabetes mellitus, type I interferon appears to contribute to the development of autoimmunity and disease progression in multiple autoimmune diseases, while maintaining some capacity to control established disease - particularly at local sites of inflammation. Recent studies in both rheumatoid arthritis and multiple sclerosis suggest that quantification of type I interferon activity or target gene expression might be informative in predicting responses to distinct classes of therapeutic agents.
[A]: Which is the most common gene signature in Rheumatoid Arthritis patients?


[Q]: The Quarrymen (also written as ''the Quarry Men'') are a British skiffle/rock and roll group, formed by John Lennon in Liverpool in 1956, which eventually evolved into the Beatles in 1960.
[A]:
From what city is the band The Quarrymen?