In this task, you're given a paragraph from the research paper and your task is to generate a suitable title for the research paper based on the given paper. Under 100 words is a good title length.
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Question: Background: The novel corona virus SARS-CoV-2 (COVID-19) can infect healthcare workers. We developed an institutional algorithm to protect operating room team members during the COVID-19 pandemic and rationally conserve personal protective equipment (PPE). Study Design: An interventional platform (operating room, interventional suites, and endoscopy) PPE taskforce was convened by the hospital and medical school leadership and tasked with developing a common algorithm for PPE use, to be used throughout the interventional platform. In conjunction with our infection disease experts, we developed our guidelines based upon potential patterns of spread, risk of exposure and conservation of PPE. A decision tree algorithm describing our institutional guidelines for precautions for operating room team members was created. This algorithm is based on urgency of operation, anticipated viral burden at the surgical site, opportunity for a procedure to aerosolize virus, and likelihood a patient could be infected based on symptoms and testing. Conclusion: Despite COVID-19 being a new threat, we have shown that by developing an easyto-follow decision tree algorithm for the interventional platform teams, we can ensure optimal healthcare worker safety.

Answer: Journal Pre-proof Precautions for Operating Room Team Members during the COVID-19 Pandemic Precautions for Operating Room Team Members during the COVID-19 Pandemic


Question: Background: Lower respiratory tract infections in the first years of life are associated with later asthma, and this observation has led to a focus on the potential causal role of specific respiratory viruses, such as rhinoviruses and respiratory syncytial virus, in asthma development. However, many respiratory viruses and bacteria trigger similar respiratory symptoms and it is possible that the important risk factors for asthma are the underlying susceptibility to infection and the exaggerated reaction to such triggers rather than the particular triggering agent. Objective: We sought to study the association between specific infections in early life and development of asthma later in childhood. Methods: Three hundred thirteen children were followed prospectively in the Copenhagen Prospective Studies of Asthma in Childhood 2000 high-risk birth cohort. Nine respiratory virus types (respiratory syncytial virus, rhinoviruses, other picornaviruses, coronaviruses 229E and OC43, parainfluenza viruses 1-3, influenza viruses AH1, AH3, and B, human metapneumovirus, adenoviruses, and bocavirus) and 3 pathogenic airway bacteria (Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis) were identified in airway secretions sampled during episodes of troublesome lung symptoms in the first 3 years of life. Asthma was determined by age 7 years. Results: In unadjusted analyses, all viruses and pathogenic bacteria identified during episodes of troublesome lung symptoms were associated with increased risk of asthma by age 7 years with similar odds ratios for all viruses and pathogenic bacteria. After adjustment for the frequency of respiratory episodes, the particular triggers were no longer associated with asthma. Conclusion: The number of respiratory episodes in the first years of life, but not the particular viral trigger, was associated with later asthma development. This suggests that future research should focus on the susceptibility and exaggerated response to lower respiratory tract infections in general rather than on the specific triggering agent. (J Allergy Clin Immunol 2015;136:81-6.)

Answer: Association between respiratory infections in early life and later asthma is independent of virus type


Question: 2 3 Halim Maaroufi 4 Institut de biologie intégrative et des systèmes (IBIS). Université Laval. Quebec. Canada 5 Halim.maaroufi@ibis.ulaval.ca 6 7 ABSTRACT The novel betacoronavirus (SARS-CoV-2) is highly contagious and can cause 8 serious acute respiratory illness syndromes, often fatal, called covid-19. It is an urgent priority to 9 better understand SARS-CoV-2 infection mechanisms that will help in the development of 10 prophylactic vaccines and therapeutics that are very important to people health and socioeconomic 11 stability around the world. The surface coronavirus spike (S) glycoprotein is considered as a key 12 factor in host specificity because it mediates infection by receptor-recognition and membrane 13 fusion. Here the analysis of CoV-2 S protein revealed in S1subunit a B56-binding LxxIxE-like 14 motif that could recruit the host protein phosphatase 2A (PP2A). This motif is absent in SARS-15 CoV and MERS-CoV. PP2A is a major family of serine/threonine phosphatases in eukaryotic cells. 16 Phosphatases and kinases are big players in the regulation of pro-inflammatory responses during 17 pathogenic infections. Moreover, studies have shown that viruses use multiple strategies to target 18 PP2A in order to manipulate host's antiviral responses. The latest studies have indicated that 19 SARS-CoV-2 is involved in sustained inflammation in the host. Therefore, by controlling acute 20 inflammation; it is possible to eliminate its dangerous effects on the host. Among efforts to fight 21 covid-19, the interaction between LxxIxE-like motif and PP2A-B56-binding pocket could be a 22 target for the development of a bioactive peptide and ligand inhibitors for therapeutic purposes. 23 24 25

Answer:
The Spike Protein S1 Subunit of SARS-CoV-2 Contains an LxxIxE-like Motif that is Known to Recruit the Host PP2A-B56 Phosphatase