Given a passage with a context and an answer, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.

[EX Q]: Context: Cytotechnologists and pathologists often perform onsite evaluations of thyroid fine-needle aspirations (FNAs) to provide immediate feedback regarding whether adequate material has been obtained for cytologic diagnosis. The current study was designed to determine whether onsite adequacy assessment results in a significant decrease in nondiagnostic specimens between ultrasound (US)-guided FNAs of the thyroid and those performed by palpation alone.', 'A search was performed to identify in-house thyroid FNAs performed between January 1, 2000 and December 31, 2003 that were obtained under US guidance or by palpation only. It was then recorded whether an onsite adequacy assessment was performed. The submitting physician and final diagnosis also were recorded for each case. Contingency tables were constructed and evaluated using chi-square analysis.', 'Of 1502 in-house thyroid FNAs included in the current study, 981 (65.3%) were performed under US guidance and 521 (34.7%) were performed with palpation alone. Onsite adequacy assessment of the aspirated material was performed in 323 cases (21.5%), whereas 1179 cases (78.5%) were performed without onsite evaluation. Of the 418 palpation-guided FNAs that were performed without adequacy assessment, 70 (16.7%) were reported to be nondiagnostic, whereas of the 103 palpation-guided FNAs with immediate evaluation, only 7 (6.8%) were determined to be inadequate for diagnosis. This difference was statistically significant (P < 0.025). Of 761 US-guided FNAs without immediate adequacy assessment, 54 (7.1%) were nondiagnostic, which was not statistically different from the nondiagnostic rate of 4.5% (10 of 220 cases) for US-guided FNAs with onsite evaluation. However, when these US-guided FNAs were divided further into 2 groups based on the experience of the radiologist performing the FNA, the nondiagnostic rate in the group of experienced radiologists was only 5.4% (or 32 of 592 US-guided FNAs), even though onsite evaluation was not performed. Among radiologists with less experience, adequacy assessment significantly reduced the nondiagnostic rate from 13.0% (22 of 169 FNAs without adequacy assessment) to 4.5% (10 of 220 FNAs with adequacy assessment) (P < 0.01).
Answer: The results of the current study demonstrate that onsite adequacy assessment of thyroid FNAs significantly reduces the number of nondiagnostic aspirates. However, the benefit of onsite evaluation, at least for US-guided FNAs, depends on the experience of the radiologist. In the current study, experienced radiologists with a relatively low nondiagnostic rate did not benefit from onsite adequacy assessment. This finding confirms the importance of experience in the performance of FNA, but suggests that onsite adequacy assessment may assist the less experienced operator.
[EX A]: Is the value of onsite adequacy assessment of thyroid fine-needle aspirations a function of operator experience?

[EX Q]: Context: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. The aim of the present study was to investigate the role of CALPAIN-5 (CAPN5) gene in PCOS susceptibility.', 'We analysed four intronic polymorphisms of the CAPN5 gene in 148 well-characterized women with PCOS and 606 unrelated controls. We performed a case-control study and an intracohort analysis of clinical characteristics associated with PCOS.', 'Analysis of haplotypes distribution between PCOS population compared to controls showed a strong deviation (P = 0.00029). The haplotypes GGCA and GGTG were overrepresented in PCOS patients (P = 0.009 and P = 0.001, respectively). In addition, we identified several CAPN5 haplotypes associated with phenotypic differences observed between PCOS patients, such as the presence of obesity (P = 0.02), cardiovascular complications (P = 0.02), familial antecedents of obesity (P = 0.003) and of hypertension (P = 0.007) and type 2 diabetes mellitus aggregation (P = 0.04).
Answer: These results suggest a role of CAPN5 gene in PCOS susceptibility in humans. Moreover, novel candidate risk alleles have been identified, within CAPN5 gene, which could be associated with important phenotypic and prognosis differences observed in PCOS patients.
[EX A]: Are specific haplotypes of the CALPAIN-5 gene associated with polycystic ovary syndrome?

[EX Q]: Context: To determine the effects of supplemental fiber on plasma p-cresol, stool frequency, and quality of life (QoL) in chronic kidney disease (CKD) patients.', 'In a 12-week single-blind study, participants were provided with control muffins and supplements (5.5\xa0g sucrose/day) for 2\xa0weeks, muffins containing 10\xa0g/day pea hull fiber and control supplements for 4\xa0weeks, and muffins with 10\xa0g/day pea hull fiber and 15\xa0g/day inulin as a supplement for 6\xa0weeks.', 'Individuals with CKD (n\xa0=\xa013; 6 males, 7 females; aged 65\xa0±\xa03\xa0years; estimated glomerular filtration rate <50\xa0mL/minute/1.73(2)) completed the study.', 'Plasma p-cresol was determined by gas chromatography-mass spectrometry, stool frequency by 5-day journals, and QoL by the KDQOL-36™.', 'Plasma p-cresol decreased from 7.25\xa0±\xa01.74\xa0mg/L during week 1 to 5.82\xa0±\xa01.72\xa0mg/L during week 12 (P\xa0<\xa0.05), and in participants with high compliance (>70% inulin intake), from 6.71\xa0±\xa01.98\xa0mg/L to 4.22\xa0±\xa01.16\xa0mg/L (P\xa0<\xa0.05). Total fiber intake increased from 16.6\xa0±\xa01.7\xa0g/day during control to 26.5\xa0±\xa02.4\xa0g/day (P\xa0<\xa0.0001) with the added pea hull and to 34.5\xa0±\xa02.2\xa0g/day with pea hull and inulin (P\xa0<\xa0.0001). Stool frequency increased from 1.4\xa0±\xa00.2 stools/day during control to 1.9\xa0±\xa00.3 stools/day during both fiber periods (P\xa0<\xa0.05). No change in overall QoL was observed.
Answer: Supplementing the diet of CKD patients with fiber may be a dietary therapy to reduce p-cresol and improve stool frequency.
[EX A]:
Does fiber supplementation lower plasma p-cresol in chronic kidney disease patients?