In this task, you are given the abstract of a research paper. Your task is to generate a summary of this abstract. Your summary should not be very short, but it's better if it's not more than 30 words.

It is well-known that deeper neural networks are harder to train than shallower ones. In this short paper, we use the (full) eigenvalue spectrum of the Hessian to explore how the loss landscape changes as the network gets deeper, and as residual connections are added to the architecture. Computing a series of quantitative measures on the Hessian spectrum, we show that the Hessian eigenvalue distribution in deeper networks has substantially heavier tails (equivalently, more outlier eigenvalues), which makes the network harder to optimize with first-order methods. We show that adding residual connections mitigates this effect substantially, suggesting a mechanism by which residual connections improve training.
Network depth increases outlier eigenvalues in the Hessian. Residual connections mitigate this.

One of the most successful techniques in generative models has been decomposing a complicated generation task into a series of simpler generation tasks.   For example, generating an image at a low resolution and then learning to refine that into a high resolution image often improves results substantially.   Here we explore a novel strategy for decomposing generation for complicated objects in which we first generate latent variables which describe a subset of the observed variables, and then map from these latent variables to the observed space.   We show that this allows us to achieve decoupled training of complicated generative models and present both theoretical and experimental results supporting the benefit of such an approach.  
Decompose the task of learning a generative model into learning disentangled latent factors for subsets of the data and then learning the joint over those latent factors.  

Somatic cancer mutation detection at ultra-low variant allele frequencies (VAFs) is an unmet challenge that is intractable with current state-of-the-art mutation calling methods. Specifically, the limit of VAF detection is closely related to the depth of coverage, due to the requirement of multiple supporting reads in extant methods, precluding the detection of mutations at VAFs that are orders of magnitude lower than the depth of coverage. Nevertheless, the ability to detect cancer-associated mutations in ultra low VAFs is a fundamental requirement for low-tumor burden cancer diagnostics applications such as early detection, monitoring, and therapy nomination using liquid biopsy methods (cell-free DNA). Here we defined a spatial representation of sequencing information adapted for convolutional architecture that enables variant detection at VAFs, in a manner independent of the depth of sequencing. This method enables the detection of cancer mutations even in VAFs as low as 10x-4^, >2 orders of magnitude below the current state-of-the-art. We validated our method on both simulated plasma and on clinical cfDNA plasma samples from cancer patients and non-cancer controls. This method introduces a new domain within bioinformatics and personalized medicine – somatic whole genome mutation calling for liquid biopsy.

 Current somatic mutation methods do not work with liquid biopsies (ie low coverage sequencing), we apply a CNN architecture to a unique representation of a read and its ailgnment, we show significant improvement over previous methods in the low frequency setting.