Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: Zach Conroy and Celeste Mercier are the hottest couple on and off the ice until a nasty spill knocks Celeste out of competition. With their dreams of gold medals put in ice and their romance chilling as a result, Zach has to find another partner for the championship in Paris. And fast. In glides Alejandra Alex Delgado, a beautiful, tough talking hockey player with fierce moves and a fearless skating style. Zachs willing to give her a chance, but his coach, Bryan quits in a huff to train Zachs biggest rivals, Cindy Halgyord and Jason Bright. That leaves Zach with a newbie partner and no coach until he convinces former figure skating champ Jackie Dorsey to step in. She puts Zach and Alex through their paces, but the hardest trick of all is keeping them focused on practice and not each other as they bicker and struggle with a growing attraction both on and off the ice. Jackie knows these kids are fire and ice, and sees the chemistry between them. She also knows that if they cant get it together, theyll set the skating world on fire. That is, if the heat between them doesnt cause a total meltdown. With the competition fierce and the stakes higher than ever, the only way Zach and Alex can win is by putting aside their feelings and pulling out a secret weapon: the deadly Pamchecko jump. But is it worth the risk? Can Zach rise above the past and his history of injuring partners? And can Alex prove that shes got the moves to match her passion? It all comes down to the biggest moment of their lives when they learn that sometimes on the ice and in life youve got to risk it all.

A: Who refuses to coach the pair?
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Q: Chronic myeloid leukemia (CML) is caused by Bcr-Abl, a constitutively active tyrosine kinase that is the result of a reciprocal translocation between chromosomes 9 and 22 and cytogenetically evident as the Philadelphia chromosome. Imatinib (Glivec, Gleevec), a specific small molecule inhibitor of Bcr-Abl, has become the standard drug therapy for CML, and has dramatically diminished the use of allogeneic stem cell transplantation. Despite unprecedented rates of complete cytogenetic response, residual disease remains detectable in the majority of patients, suggesting that imatinib fails to eradicate leukemic stem cells. In this publication, the current perspectives for CML patients treated with imatinib are reviewed, focusing on the results of both standard and high-dose therapy. Monitoring of time-dependent prognostic factors is reviewed. The reasons imatinib may not be able to eradicate the disease are discussed, and potential strategies to achieve disease elimination are presented. Lastly, resistance to imatinib and the potential of second-generation Abl kinase inhibitors in the setting of clinical resistance are considered.

A: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
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Q: Viewed as paranoid and dangerous, An Lushan was assassinated in 757 by his own son, An Qingxu, after which the state of Yan continued to spiral into a turmoil that eventually led to its collapse in 763.

A:
What noble family was An Lushan part of?
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