Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

[EX Q]: Context: Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia chromosome, which is associated with a balanced translocation involving chromosomes 9 and 22 to produce a fusion gene (bcr-abl) that gives rise to a constitutively activated Abl tyrosine kinase. This kinase led to the discovery of several small-molecule inhibitors, imatinib being the first and most successful of these. Resistance to imatinib results in some patients from Abl kinase point mutations. Overcoming imatinib resistance represents one of the biggest challenges facing clinicians in the modern management of CML. In this review, we discuss the current understanding of CML pathophysiology and mechanisms of imatinib resistance and how advancing this knowledge has led to the design of novel therapies in the area of blastic phase CML and Philadelphia chromosome-positive acute lymphoblastic leukemia with previous imatinib failure. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
[EX A]: bcr-abl

[EX Q]: Context: Spleen tyrosine kinase (SYK) has come into focus as a potential therapeutic target in chronic inflammatory diseases, such as rheumatoid arthritis and asthma, as well as in B-cell lymphomas. SYK has also been involved in the signaling of immunoreceptors, cytokine receptors, and integrins. We therefore hypothesized that inhibition of SYK attenuates the inflammatory process underlying atherosclerosis and reduces plaque development. Low-density lipoprotein receptor-deficient mice consuming a high-cholesterol diet supplemented with 2 doses of the orally available SYK inhibitor fostamatinib for 16 weeks showed a dose-dependent reduction in atherosclerotic lesion size by up to 596% compared with the respective controls. Lesions of fostamatinib-treated animals contained fewer macrophages but more smooth muscle cells and collagen-characteristics associated with more stable plaques in humans. Mechanistically, fostamatinib attenuated adhesion and migration of inflammatory cells and limited macrophage survival. Furthermore, fostamatinib normalized high-cholesterol diet -induced monocytosis and inflammatory gene expression. We present the novel finding that the SYK inhibitor fostamatinib attenuates atherogenesis in mice. Our data identify SYK inhibition as a potentially fruitful antiinflammatory therapeutic strategy in atherosclerosis. 
 Question: Which enzyme is inhibited by a drug fostamatinib?
[EX A]: spleen tyrosine kinase

[EX Q]: Context: Following their victory over the Patriots, the Steelers remained at home the next week for their second match-up of the season against division rivals the Baltimore Ravens. The Ravens scored first with an 18-yard field goal by kicker Billy Cundiff, the only points scored in the first quarter by either team. Steelers kicker Shaun Suisham answered with a 36-yard field goal early in the second quarter, and a 30-yard field goal near the end, but both of these were quickly matched by Baltimore's Cundiff with a 43-yard and 51-yard field goal, respectively, giving Baltimore a 9-6 lead at halftime. The Ravens then increased their lead in the third quarter when Ray Rice scored the first touchdown of the game on a 4-yard run. The Steelers rallied hard in the fourth quarter, with running back Rashard Mendenhall making a 1-yard run to score a touchdown, and then taking the lead for the first time in the game when quarterback Ben Roethlisberger made a successful 25-yard pass to wide receiver Mike Wallace in the endzone for a second touchdown. On their final drive of the game, the Steelers were ready to potentially increase their lead with a 47-yard field goal kick by Shaun Suisham, but a 5-yard delay of game penalty put them out of field goal range and they were instead forced to punt the ball to the Ravens. The Ravens then began a 92-yard drive, culminating in a 26-yard touchdown pass by quarterback Joe Flacco to wide receiver Torrey Smith in the endzone with just 8 seconds remaining, giving them the game. 
 Question: Who kicked the two longest field goals of the game?
[EX A]:
billy cundiff