Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: It was the last KH-2 Corona' satellite, which was based on an Agena-B. The launch of Discoverer 28 occurred at 00:01 UTC on 4 August 1961.
[A]: When was the launch date of Discoverer 28?


[Q]: Chronic myeloid leukemia (CML) is characterized by the Philadelphia translocation that fuses BCR sequences from chromosome 22 upstream of the ABL gene on chromosome 9. The chimerical Bcr-Abl protein expressed by CML cells has constitutive tyrosine kinase activity, which is essential for the pathogenesis of the disease. Imatinib, an ATP-competitive selective inhibitor of Bcr-Abl, has unprecedented efficacy for the treatment of CML. Most patients with early stage disease achieve durable complete hematological and complete cytogenetic remissions, with minimal toxicity. In contrast, responses are less stable in patients with advanced CML. This review highlights the pathogenesis of CML, its clinical features, and the development of imatinib as a specific molecularly targeted therapy. Aspects of disease monitoring and side effects are covered as well as resistance to imatinib and strategies to overcome resistance, such as alternative signal transduction inhibitors and drug combinations. Perspectives for further development are also discussed.
[A]: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


[Q]: Ends and Means (an Enquiry Into the Nature of Ideals and Into the Methods Employed for Their Realization) is a book of essays written by Aldous Huxley.
[A]:
Which author wrote the novel titled Ends and Means?