Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: To validate the presence and demonstrate the clinical value of the type I interferon (IFN)-signature during arthritis development. In 115 seropositive arthralgia patients who were followed for the development of arthritis (Amsterdam Reade cohort), and 25 presymptomatic individuals who developed rheumatoid arthritis (RA) later, and 45 population-based controls (Northern Sweden cohort), the expression levels of 7 type I IFN response genes were determined with multiplex qPCR and an IFN-score was calculated. The diagnostic performance of the IFN-score was evaluated using Cox regression and Receiver Operating Characteristics (ROC)-curve analysis. In 44 of the 115 at-risk individuals (38%) from the Amsterdam Reade cohort, arthritis developed after a median period of 8 months (IQR 5-13). Stratification of these individuals based on the IFN-score revealed that 15 out of 25 IFN(high) individuals converted to arthritis, compared with 29 out of 90 IFN(low) individuals (p=0.011). In the Northern Sweden cohort, the level of the IFN-score was also significantly increased in presymptomatic individuals who developed RA compared with population-based controls (p=0.002). Cox regression analysis of the Amsterdam Reade cohort showed that the hazard ratio (HR) for development of arthritis was 2.38 (p=0.008) for IFN(high) at-risk individuals after correction for anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF). The ROC-curve area under the curve (AUC) for the IFN-score combined with ACPA and RF in the prediction of arthritis was 78.5% (p=0.0001, 95% CI 0.70 to 0.87). The results demonstrated clinical utility for the IFN-signature as a biomarker in the prediction of arthritis development.
[A]: Which is the most common gene signature in Rheumatoid Arthritis patients?


[Q]: Les Abencerages, ou L'etendard de Grenade (English: The Abencerrages, or The Standard of Granada) is an opera in three acts by Luigi Cherubini with a French libretto by Etienne de Jouy, based on the novel Gonzalve de Cordoue by Jean-Pierre Claris de Florian.
[A]: Which place is Les Abencérages in?


[Q]: Gotham City's geography, like other fictional cities' geographies in the DC Universe, has varied over the decades, because of changing writers, editors, and storylines.
[A]:
What type of universe is Gotham City a fictional character in?