TASK DEFINITION: Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.
PROBLEM: Paragraph: The FDA has set a May 2020 deadline for e-cigarette makers to submit a formal application to keep their products on the market amid its efforts to curb the use of e-cigarette among teens. Reynolds, whose Vuse e-cigarettes deliver nicotine via a cartridge-based vapor system, said it had provided the health regulator with over 150,000 pages of documentation, including information on the composition, design and manufacturing process associated with its product, as well as safety data. The company said it had also worked with a team of more than 100 people to prepare the filing, including multiple regulatory experts and scientists. U.S. regulators are exploring ways to monitor the manufacturing and marketing of e-cigarettes following a rise in use of these products among teens, and a recent outbreak of a mysterious lung illness linked to vaping that has claimed at least 29 lives. Vaping devices such as Juul’s, which vaporize liquid containing nicotine, have borne the brunt of the regulatory crackdown globally. The Trump administration also outlined plans in September to remove all flavored e-cigarettes from store shelves, pointing the finger at sweet flavors that had drawn millions of children into nicotine addiction. Claim: Reynolds American files for FDA review of e-cigarette.

SOLUTION: British American Tobacco Plc unit Reynolds American Inc said on Friday it had filed for a review of its Vuse e-cigarettes by the U.S. Food and Drug administration, giving it a lead over its main rival Juul Labs Inc.

PROBLEM: Paragraph: According to two studies published on Wednesday, DNA from these pre-modern humans may play a role in the appearance of hair and skin as well as the risk of certain diseases. Although Neanderthals became extinct 28,000 years ago in Europe, as much as one-fifth of their DNA has survived in human genomes due to interbreeding tens of thousands of years ago, one of the studies found, although any one individual has only about 2 percent of caveman DNA. “The 2 percent of your Neanderthal DNA might be different than my 2 percent of Neanderthal DNA, and it’s found at different places in the genome,” said geneticist Joshua Akey, who led one of the studies. Put it all together in a study of hundreds of people, and “you can recover a substantial proportion of the Neanderthal genome.”  Both studies confirmed earlier findings that the genomes of east Asians harbor more Neanderthal DNA than those of Europeans. This could be 21 percent more, according to an analysis by Akey and Benjamin Vernot, published online in the journal Science. Still, “more” is a relative term. According to the paper by geneticists at Harvard Medical School, published in Nature, about 1.4 percent of the genomes of Han Chinese in Beijing and south China, as well as Japanese in Tokyo come from Neanderthals, compared to 1.1 percent of the genomes of Europeans. Anthropologists expressed caution about the findings. Fewer than half a dozen Neanderthal fossils have yielded genetic material, said Erik Trinkaus of Washington University in  St. Louis, one of the world’s leading experts on early humans. Using this small sample to infer how much Neanderthal DNA persists in today’s genome is therefore questionable, he said. As expected, since Neanderthals never existed in Africa, Africans and those who trace their ancestry to that continent have almost no Neanderthal DNA, the Harvard team found. Human ancestors began migrating out of humanity’s natal continent as early as 1 million years ago, paleoanthropologists infer from fossil evidence, and between 500,000 and 200,000 years ago evolved into the robust, large-browed Homo neanderthalensis in Western Europe. Ever since scientists extracted DNA from the remains of Neanderthals, they have known that people today carry snippets of cavemen genes, in the amounts of 2 percent to 3 percent. That clinched the case that Neanderthals and modern humans interbred, probably 40,000 to 80,000 years ago, soon after the latter arrived in Europe from Africa. The new studies add details about how much DNA and of what kind we inherited. “The story of early human evolution is captivating in itself, yet it also has far-reaching implications for understanding the organization of the modern human genome,” Irene Eckstrand of the National Institutes of Health’s National Institute of General Medical Sciences, which partially funded the research, said in a statement. “Every piece of this story that we uncover tells us more about our ancestors’ genetic contributions to modern human health and disease.”  The Harvard team used a novel genetic algorithm to estimate the probability that a particular genetic variant arose from Neanderthals. Basically, they started with the genome of a 50,000-year-old Neanderthal, and determined whether pieces of it also appeared in some non-Africans but not in sub-Saharan Africans. The algorithm identified remnants of Neanderthal DNA, called alleles, in genes associated with type 2 diabetes, Crohn’s disease, lupus, biliary cirrhosis and smoking behavior. “But we can’t tell if the Neanderthal alleles are contributing to disease,” said Harvard’s Sriram Sankararaman, lead author of the paper in Nature. Areas “with increased Neanderthal ancestry tend to be higher the farther away you go from genes,” sitting, instead, in regions of the genome that do not actually produce the proteins, enzymes and other working molecules of the body. Neanderthal DNA does sit within some genes, however, such as those for keratin, a fibrous protein that makes skin, hair and nails tough and can be beneficial in colder environments by providing thicker insulation. The endurance of this Neanderthal DNA suggests that our caveman inheritance was adaptive, picked by natural selection to persist in our genome, generation after generation, because it conferred a survival advantage in individuals who carried it. The Harvard team analyzed the genomes of 1,004 people to estimate which populations got more or fewer Neanderthal DNA. Confirming a 2013 study, they found more in the genomes of east Asians than in Europeans. But they also dug deeper. Puerto Ricans and Spaniards have the least Neanderthal DNA, 1.05 percent and 1.07 percent respectively. That is curious because Neanderthals made their last stand on the Iberian peninsula, finally dying out there 28,000 years ago. Across all populations, Neanderthal DNA is conspicuously low in regions of the X chromosome and in testes-specific genes. The paucity of Neanderthal genes among those active in the testes suggests that interbreeding wasn’t a resounding success: It produced viable children, but the males were infertile. Although as much as 20 percent of Neanderthal DNA persists in modern genomes, according to the Washington scientists, vast regions of the latter are Neanderthal deserts. Among them is a region of chromosome 7 that includes a gene called FOXP2. “FOXP2 has previously been implicated in speech and language and may be an example of a gene that influences a uniquely human trait, which is why we find no Neanderthal sequences in these regions,” said Akey. Claim: Modern humans more Neanderthal than once thought, studies suggest.

SOLUTION: It’s getting harder and harder to take umbrage if someone calls you a Neanderthal.

PROBLEM: Paragraph: "Scott Henson of Austin, who writes the Grits for Breakfast blog on criminal justice policy and politics, told the Austin Post, an online community newspaper, that Texas and the nation have ""criminalized far too much of public life."" ""I think we have somewhere in the range of 2,500 or so felonies on the books in Texas,"" Henson said in an interview posted online Feb. 25, 2013. ""There are 11 different felonies you can commit with an oyster."" That cracked our interest, partly because the conservative Texas Public Policy Foundation likewise said about a month earlier that Texas has 11 felonies (not a dozen, dang it) related to harvesting oysters. Felonies are considered the most serious criminal offenses. By email, the center’s Marc Levin, director of its Center for Effective Justice, pointed out a January 2012 publication, the ""Current Offense Severity Rankings List,"" written by the Texas Board of Pardons and Paroles. Henson told us by email that Levin was his source for the count when he initially wrote about the topic in 2007. He also said he would check his claim against the state’s ""offense severity"" list. Among the state-listed 2,324 felonies, Levin said, some are rather similar or are enhancements of lesser offenses, though the agency ""presumably uses a consistent methodology to delineate each separate offense."" He said the tally of oyster-related felonies aired by the foundation ""allows for some that the parole board counts as separate offenses which some might consider to be essentially the same offense."" We spotted 16 oyster-connected felonies on the list but pruned three that appeared to be duplicates. Also, as Levin noted, two felonies appeared distinct from others only because they take into consideration repeat offenses. Theft of oysters from a private bed is a felony, as is theft of oysters from a private bed and having two or more previous convictions. Similarly, harvesting oysters in a restricted area is a felony, as is oystering in a restricted area with a previous conviction. Adjusting for the seeming duplications and near-similar felonies knocked the oyster-tied felonies in state law to 11: theft of oysters placed on a private seabed; interfering with an oyster buoy or marker with two previous convictions; oystering in a restricted area as designated by the state; night dredging of oysters; night dredging in a restricted area with a previous conviction; night dredging in a polluted area; not having an oystering license; harvesting oysters for non-commercial purposes without a license; harvesting oysters without a commercial license; selling sport oysters; and violating oyster regulations. By telephone and email, a Texas Parks and Wildlife Department official confirmed the felonies, though Brandi Reeder, the agency’s fisheries law administrator, stressed that a person could be charged with each felony only if they have been convicted of similar misdemeanor violations in the previous five years--sometimes just once, in other cases two or more times, according to the relevant statutes. At our request, Reeder reviewed our identified 11 felonies, later saying by email that she would say there are seven distinct oyster-related offenses or crimes. Broadly, Reeder said, the oyster felonies are in place for a reason, to deter nefarious, potentially risky activities. ""An oyster can kill you,"" Reeder said, referring to the possible presence of viruses, bacteria and parasites in raw shellfish. ""That’s why we take it seriously."" But Texans rarely face oyster felony charges, Reeder said, because nearly all offenders stop after being charged with a misdemeanor. Statewide in the fiscal year ending Aug. 31, 2012, according to the agency, no such felonies were charged. By telephone, neither Henson nor Levin expressed surprise that no oyster felonies were charged in a recent year or that no one can be charged with such a felony without a prior misdemeanor conviction. With a laugh, Henson said: ""I guess the laws worked. They stamped out oyster crime in Texas."" Henson and Levin each said, too, the oyster felonies demonstrate regulatory issues--such as having a license or fishing in restricted waters--being placed inappropriately into criminal statutes. Levin said there is an opportunity to shrink the number of state crimes starting from a Texas House proposal to create a commission that would recommend changes in advance of the 2015 legislative session. Our ruling Henson said there are 11 Texas felonies one can commit with an oyster. He could have said 16, according to the state’s breakdown of felony offenses, though Parks & Wildlife suggests such  oyster-related crimes break down to seven distinct offenses. Significantly, too, these felony charges are rare. No one can even face one without having previously been convicted of at least one related misdemeanor.s ." Claim: "Scott Henson Says Texas has ""11 different felonies you can commit with an oyster."

SOLUTION:
Henson said there are 11 Texas felonies one can commit with an oyster. He could have said 16, according to the state’s breakdown of felony offenses, though Parks & Wildlife suggests such  oyster-related crimes break down to seven distinct offenses. Significantly, too, these felony charges are rare. No one can even face one without having previously been convicted of at least one related misdemeanor.