Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
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Question: Question: Does protamine affect the formation of cGMP or cAMP in pig vascular smooth muscle cells in response to vasodilators?
Answer: These experiments show that protamine does not alter the responses of the intracellular second messengers, cGMP and cAMP, to the vasodilators sodium nitroprusside, atrial natriuretic peptide, isoproterenol, and forskolin. These results do not support the hypothesis that protamine sensitizes vascular smooth muscle cells to the endothelium-derived relaxing factor, nitric oxide.

Answer: no


Question: Question: Is daily physical activity in patients with chronic obstructive pulmonary disease mainly associated with dynamic hyperinflation?
Answer: Daily physical activity of patients with COPD is mainly associated with dynamic hyperinflation, regardless of severity classification.

Answer: yes


Question: Question: Do mid-regional proadrenomedullin levels predict recurrence of atrial fibrillation after catheter ablation?
Answer: This is the first study revealing the association between MR-proADM elevation before ablation and poor outcomes after ablation of AF. Larger studies are needed to validate these results.

Answer:
yes