You will be given a trivia clue, and the category it belongs to. You should answer with the best answer that belongs in the category and is described by the clue. For simplicity, answers should be in all lower cased letters.

[Q]: Category: PLAGUES & PESTILENCE 
Clue: Having first escaped from a South American research lab in 1957, they became a threat to the U.S. in 1990
[A]: killer bees


[Q]: Category: U.S. CITIES 
Clue: Founded in 1758, it's named for a British prime minister who was a noted defender of the American Colonists
[A]: pittsburgh


[Q]: Category: 20th CENTURY BOOKS 
Clue: Chapter I of this book tells us: "Worse than the ordinary miserable childhood is the miserable Irish childhood..."
[A]:
angela\'s ashes