instruction:
Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
question:
Approximately 5-6% of intravaginal clindamycin is absorbed in the bloodstream, making systemic effects possible.
answer:
non-adverse drug event


question:
BACKGROUND: Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy.
answer:
adverse drug event


question:
A new type of minocycline-induced cutaneous hyperpigmentation.
answer:

adverse drug event