instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
Patients with multiple myeloma (MM) experience pathologic fractures, bone pain, hypercalcemia, neurologic symptoms, and renal insufficiency with substantial morbidity and mortality. Bisphosphonates have been used successfully for the management of MM-related bone disease. Increased incidence of osteonecrosis of the jaw has been observed in patients with cancer receiving bisphosphonate therapy. Recent advances in the pathobiology of MM-related bone disease and other cancer-related bone metastases have led to the identification of novel therapeutic targets, such as receptor activator of nuclear factor-kappaB (RANK); its ligand (RANKL); and a decoy receptor, osteoprotegerin, for the development of potential targeted agents. Initials studies have demonstrated that targeting RANK/ RANKL signaling with the fully human monoclonal antibody denosumab prevented skeletal complications in patients with MM and other cancers with bone metastases. Ongoing studies evaluating the clinical utility of denosumab in cancer- related bone destruction have been discussed. In addition, several potential targets, such as macrophage inflammatory protein-1alpha, chemokine receptors 1 and 5, interleukin-3, and Wnt signaling, are b riefly described.
answer:
To the ligand of which receptors does Denosumab (Prolia) bind?


question:
The movie opens with James Reece (Jonathan Rhys Meyers) driving through the streets of Paris in a black SUV to work. Reece works in the American Embassy as an aide to Ambassador Bennington (Richard Durden), the U.S. Ambassador to France. Taking a delivery of some forms from the Ambassador's secretary, he goes over Bennington's itinerary for the next few days, centering around a major summit in which the U.S., France, and several other nations are preparing foreign aid to the African continent. Bennington shows that he is more absorbed right now in a chess game he's playing with Reece during all this time. Despite paying less attention to the board and the game than Bennington is, Reece quickly checkmates him to win.Reece receives a call from an unknown source (voiced by David Gasman) directing him to a silver BMW in the parking lot, excusing himself with a cover story to Bennington that he has to review the Summit's planned seating arrangement. Going to the parking lot, Reece opens a code-locked security compartment in the trunk of his SUV to reveal a firearm and several French license plates. He removes the license plate from the silver BMW and replaces it with one of the plates he has stowed away in his SUV. He then moves his SUV to another parking space and waits there, watching the silver BMW. He watches several men get into the vehicle, put a briefcase into its trunk, and drive away.Arriving home, Reece gets another call from the same source. Reece is in fact a CIA operative working in the Embassy as a cover. He does minor jobs for his superiors, and is eager to move up into Special Ops. His superior assures him he'll get his chance, but for right now he is needed to secure a hidden transmission chip in the French Foreign Minister's office during a meeting with Ambassador Bennington. Reece doesn't believe he was given a chip, but is told it's in his left jacket pocket. Checking his jacket, he finds the chip there.Sitting in his apartment, Reece examines the chip. He is interrupted by a knock on his door. It's his girlfriend, Caroline (Kasia Smutnak) (pronounced Cah-roll-een, the 'ine' being pronounced like in the word 'magazine'). Caroline kisses Reece and tells him she has a surprise. She sits him in a chair and makes him keep his back to her. He can hear her undressing and changing into a different outfit. When she tells him to look, his jaw drops at the sight of her wearing a sexy strapless dress. He thinks he recognizes the fabric, and Caroline tells him she made it out of their bedroom curtains-- Caroline is a clothing designer. The two of them quickly start to undress as they head into the bedroom to make out.Reece arrives the next day at the conference site to give Bennington a summary of what is intended to be discussed at the meeting. Bennington invites Reece to attend the meeting with him.During the meeting, Reece discreetly takes the chip (disguising it by putting a piece of gum in his mouth and offering another piece to the Minister's secretary) and tries to put it under the lampstand beside his seat, using his chewing gum as an adhesive. However, the gum fails to hold and twice it falls back to the floor in plain sight. Frustrated, and barely managing to keep the chip hidden, as a diversion Reece finally questions the Foreign Minister (Eric Godon) about his having several Goyas in his office. The Minister says he does, and offers to show them to Bennington, who is very interested in Goya art. As Bennington accompanies the Minister and secretary to see the Goyas, leaving Reece alone in the meeting room, Reece takes the stapler from the Minister's desk and staples the chip to the underside of the desk... but accidentally leaves the stapler open as he exits.Arriving home that evening, Reece is disquieted as the lights in the hallway go out. He finds what looks like a trail of blood leading to a door out onto the roof of the building. Grabbing a broom left in
answer:
What are the terrorists targeting?


question:
Past presidents of PEN International have included Alberto Moravia, Heinrich Boll, Arthur Miller, Mario Vargas Llosa, Homero Aridjis, Jiri Grusa and John Ralston Saul.
answer:

Who led PEN International?