instruction:
Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
question:
To validate the presence and demonstrate the clinical value of the type I interferon (IFN)-signature during arthritis development. In 115 seropositive arthralgia patients who were followed for the development of arthritis (Amsterdam Reade cohort), and 25 presymptomatic individuals who developed rheumatoid arthritis (RA) later, and 45 population-based controls (Northern Sweden cohort), the expression levels of 7 type I IFN response genes were determined with multiplex qPCR and an IFN-score was calculated. The diagnostic performance of the IFN-score was evaluated using Cox regression and Receiver Operating Characteristics (ROC)-curve analysis. In 44 of the 115 at-risk individuals (38%) from the Amsterdam Reade cohort, arthritis developed after a median period of 8 months (IQR 5-13). Stratification of these individuals based on the IFN-score revealed that 15 out of 25 IFN(high) individuals converted to arthritis, compared with 29 out of 90 IFN(low) individuals (p=0.011). In the Northern Sweden cohort, the level of the IFN-score was also significantly increased in presymptomatic individuals who developed RA compared with population-based controls (p=0.002). Cox regression analysis of the Amsterdam Reade cohort showed that the hazard ratio (HR) for development of arthritis was 2.38 (p=0.008) for IFN(high) at-risk individuals after correction for anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF). The ROC-curve area under the curve (AUC) for the IFN-score combined with ACPA and RF in the prediction of arthritis was 78.5% (p=0.0001, 95% CI 0.70 to 0.87). The results demonstrated clinical utility for the IFN-signature as a biomarker in the prediction of arthritis development.
answer:
Which is the most common gene signature in Rheumatoid Arthritis patients?


question:
Einsteinium was discovered as a component of the debris of the first hydrogen bomb explosion in 1952, and named after Albert Einstein.
answer:
When was Einsteinium first discovered?


question:
Mercury is released into the atmosphere when coal is burned (Figure 1.1). But breathing the mercury is not harmful. In the atmosphere, the mercury forms small droplets that are deposited in water or sediments. Do you know why you are supposed to eat large predatory fish like tuna infrequently? It is because of the bioaccu- mulation of mercury in those species. Some pollutants remain in an organism throughout its life, a phenomenon called bioaccumulation. In this process, an organism accumulates the entire amount of a toxic compound that it consumes over its lifetime. Not all substances bioaccumulate. Can you name one that does not? Aspirin does not bioaccumulate; if it did, a person would quickly accumulate a toxic amount in her body. Compounds that bioaccumulate are usually stored in the organisms fat. In the sediments, bacteria convert the droplets to the hazardous compound methyl mercury. Bacteria and plankton store all of the mercury from all of the seawater they ingest (Figure 1.2). A small fish that eats bacteria and plankton accumulates all of the mercury from all of the tiny creatures it eats over its lifetime. A big fish accumulates all of the mercury from all of the small fish it eats over its lifetime. For a tuna at the top of the food chain, thats a lot of mercury. Historic increases of mercury in the atmo- sphere: blue is volcanic eruptions; brown, purple, and pink are human-caused. The red region shows the effect of industrial- ization on atmospheric mercury. So tuna pose a health hazard to anything that eats them because their bodies are so high in mercury. This is why the government recommends limits on the amount of tuna that people eat. Limiting intake of large predatory fish is especially important for children and pregnant women. If the mercury just stayed in a persons fat, it would not be harmful, but that fat is used when a woman is pregnant or nursing a baby. A person will also get the mercury into her system when she (or he) burns the fat while losing weight. Methyl mercury poisoning can cause nervous system or brain damage, especially in infants and children. Children may experience brain damage or developmental delays. The phrase mad as a hatter was common when Lewis Carroll wrote his Alice in Wonderland stories. It was based on symptoms suffered by hatters who were exposed to mercury and experienced mercury poisoning while using the metal to make hats (Figure 1.3). Like mercury, other metals and VOCS can bioaccumulate, causing harm to animals and people high on the food chain. Mercury, a potent neurotoxin, has been flowing into the San Francisco Bay since the Gold Rush Era. It has settled in the bays mud and made its way up the food chain, endangering wildlife and making many fish unsafe to eat. Now a multi-billion-dollar plan aims to clean it up. Click image to the left or use the URL below. URL:
answer:

mercury poisoning can drive a person to be as mad as a hatter, which is based off of this novel.