Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.

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Irish-born William Campbell and Japan’s Satoshi Omura won half of the prize for discovering avermectin, a derivative of which has been used to treat hundreds of millions of people with river blindness and lymphatic filariasis, or elephantiasis. China’s Tu Youyou was awarded the other half of the prize for discovering artemisinin, a drug that has slashed malaria deaths and has become the mainstay of fighting the mosquito-borne disease. She is China’s first Nobel laureate in medicine. Some 3.4 billion people, most of them living in poor countries, are at risk of contracting the three parasitic diseases. “These two discoveries have provided humankind with powerful new means to combat these debilitating diseases that affect hundreds of millions of people annually,” the Nobel Assembly at Sweden’s Karolinska Institute said. “The consequences in terms of improved human health and reduced suffering are immeasurable.”  Today, the medicine ivermectin, a derivative of avermectin made by Merck & Co, is used worldwide to fight roundworm parasites, while artemisinin-based drugs from firms including Novartis and Sanofi are the main weapons against malaria. Omura and Campbell made their breakthrough in fighting parasitic worms, or helminths, after studying compounds from soil bacteria. That led to the discovery of avermectin, which was then further modified into ivermectin. The treatment is so successful that river blindness and lymphatic filariasis are now on the verge of being eradicated. Omura, 80, said the real credit for the achievement should go to the ingenuity of the Streptomyces bacteria, whose naturally occurring chemicals were so effective at killing off parasites. “I really wonder if I deserve this,” he said after learning he had won the prize. “I have done all my work depending on microbes and learning from them, so I think the microbes might almost deserve it more than I do.”  Omura is professor emeritus at Kitasato University in Japan, while Campbell is research fellow emeritus at Drew University in Madison, New Jersey. “This was the work of a team of researchers so it is by no means my work, it’s our work,” said Campbell, 85, who learned of his prize in a pre-dawn phone call from Reuters that woke him at his home in North Andover, Massachusetts. “In the first decade, there were 70 authors that I co-authored papers with. That gives you some idea of the number of people involved,” he said. Tu, meanwhile, turned to a traditional Chinese herbal medicine in her hunt for a better malaria treatment, following the declining success of the older drugs chloroquine and quinine. She found that an extract from the plant Artemisia annua was sometimes effective but the results were inconsistent, so she went back to ancient literature, including a recipe from AD 350, in the search for clues. This eventually led to the isolation of artemisinin, a new class of anti-malaria drug, which was available in China before it reached the West. Tu, 84, has worked at the China Academy of Traditional Chinese Medicine since 1965. World Health Organization spokesman Gregory Hartl said the award of a Nobel prize for the discovery was a great tribute to the contribution of Chinese science in fighting malaria. “We now have drugs that kill these parasites very early in their life-cycle,” said Juleen Zierath, chair of the Nobel Committee. “They not only kill these parasites but they stop these infections from spreading.”     Death rates from malaria have plunged 60 percent in the past 15 years, although the disease still kills around half a million people a year, the vast majority of them babies and young children in the poorest parts of Africa. The 8 million Swedish crowns ($960,000) medicine prize is the first of the Nobel prizes awarded each year. Prizes for achievements in science, literature and peace were first awarded in 1901 in accordance with the will of dynamite inventor and businessman Alfred Nobel. Last year, the medicine prize went to three scientists who discovered the brain’s inner navigation system.

Ex Output:
Beating parasites wins three scientists Nobel prize for medicine.


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The public-private partnership includes the World Health Organization, UNICEF, the Bill & Melinda Gates Foundation and the World Bank, among others. The funding announcement was made after a meeting of GAVI’s board. GAVI said the investment, which it called an estimate, will be provided between now and 2025. Since the current outbreak in eastern Congo was identified last August, health officials have immunized more than 255,000 people with a recently licensed vaccine made by Merck. To date there have been nearly 3,200 confirmed Ebola cases, including more than 2,200 deaths, in what has become the second deadliest Ebola outbreak in history. Dr. Ngozi Okonjo-Iweala, chair of Gavi’s board, called the creation of the Ebola vaccine stockpile a “historic milestone in humanity’s fight against this horrific disease.” GAVI said “a coordinating mechanism” to decide how and when vaccines will be used will be established with partner organizations. There are similar stockpiles for vaccines against yellow fever, meningitis and cholera. Those limited shots are doled out to developing countries by WHO, UNICEF, the Red Cross and Doctors Without Borders after receiving technical advice from others. The Ebola vaccine stockpile will be available to all countries, but only developing countries will be able to get vaccines for free in addition to support for the logistical costs of mounting vaccination campaigns. Jason Nickerson, a humanitarian affairs adviser at Doctors Without Borders, said the new stockpile would change how officials respond to future Ebola outbreaks. “Knowing how many doses of the vaccine exist in the world, and then being able to get a supply of them to high-risk countries in a very quick way, gives us another tool to respond to these outbreaks,” he said. Earlier this year, the medical charity publicly called for an independent committee to oversee Ebola vaccination efforts in Congo, saying WHO sometimes used arbitrary criteria to determine who would get immunized. It said the fact that Ebola was continuing to spread despite the large number of people vaccinated was a damning assessment of the response. Containing this outbreak has been complicated by violence and misunderstandings in a part of Congo that had never reported an Ebola case before. Last week, response activities were suspended after attacks killed four Ebola responders, including a member of a vaccination team. Multiple rebel groups operate in eastern Congo and the region has been described as a war zone. WHO has warned continued attacks on health workers and Ebola clinics could undermine attempts to curb Ebola and prompt a resurgence of the disease.

Ex Output:
Vaccine group announces creation of Ebola vaccine stockpile.


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Andee Shuster and Ben Urovitch kiss as in front of a heart shaped sculpture outside the Montreal Museum of Arts, February 13, 2005. U.S. researchers said their observational study was the first to show an independent relationship between positive emotions and coronary heart disease, but stressed that more work was needed before any treatment recommendations could be made. “We desperately need rigorous clinical trials in this area. If the trials support our findings, then these results will be incredibly important in describing specifically what clinicians and/or patients could do to improve health,” Karina Davidson of Columbia University Medical Center wrote in the study in the European Heart Journal. Heart disease is the leading killer of men and women in Europe, the United States and most industrialized countries. Together with diabetes, cardiovascular diseases accounted for 32 percent of all deaths around the world in 2005, according to the World Health Organization. Over 10 years, Davidson and her team followed 1,739 men and women who were taking part in a large health survey in Canada. Trained nurses assessed the participants’ heart disease risk and measured negative emotions like depression, hostility and anxiety, as well as positive emotions like joy, happiness, excitement, enthusiasm and contentment — collectively known as a “positive affect”. The researchers ranked the “positive affect” across five levels ranging from “none” to “extreme” and found that for each rank the risk of heart disease fell by 22 percent. Davidson, who led the research, said her findings suggested it might be possible to help prevent heart disease by enhancing people’s positive emotions. “Participants with no positive affect were at a 22 percent higher risk of ... heart attack or angina ... than those with a little positive affect, who were themselves at 22 percent higher risk than those with moderate positive affect,” she wrote. “We also found that if someone who was usually positive had some depressive symptoms at the time of the survey, this did not affect their overall lower risk of heart disease.”   Smoking, being overweight, a history of heart problems in the family and high blood pressure are traditionally seen as major risk factors for heart disease, but studies have also linked such things as intelligence and income levels to heart risks. Research published last week found intelligence is second only to smoking as a predictor of heart disease. Ellen Mason of the British Heart Foundation (BHF) advocacy group said Thursday’s study echoed previous findings which had prompted the BHF to delve deeper. “The BHF is funding science to unravel the biology that underlies this link,” she said. Davidson’s team said one possible reason for the link between happiness and heart risk could be that people who are happier tend to have longer periods of rest or relaxation, and may recover more quickly from stressful events and not spend as much time “re-living” them.

Ex Output:

Happiness makes for a healthy heart.