In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Example Input: Question: With regard to pyrogens and biotechnological medicines, it is possible to say: 
 Options:  <1> They have no tendency to aggregate or form large units with high molecular weight. <2> Ion exchange chromatography procedures (using their positive charge) can reduce endotoxin levels. <3> Ion exchange chromatography procedures (using their negative charge) can reduce endotoxin levels. <4> Ion exchange chromatography procedures (regardless of their charge) can reduce endotoxin levels. <5> They are unstable under standard autoclaving conditions.
Example Output: 3

Example Input: Question: Enzymatic regulation by phosphorylation: 
 Options:  <1> It is reversible. <2> It requires enzymes that directly introduce the Pi. <3> Introduce the Pi into acidic and basic amino acids. <4> Always activate enzymes. <5> It is carried out by phosphatases.
Example Output: 1

Example Input: Question: The only autonomic adrenergic fibers are axons of neurons: 
 Options:  <1> Sympathetic preganglions. <2> Postganglionic sympathetics. <3> Preganglionic parasympathetic. <4> Postganglionic parasympathetic. <5> Parasympathetic ganglion.
Example Output:
2