Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Example Input: Context: The Margraviate of Brandenburg (German: Markgrafschaft Brandenburg) was a major principality of the Holy Roman Empire from 1157 to 1806. 
 Question: In what year was Margraviate of Brandenburg formed?
Example Output: 1157

Example Input: Context: We report on maternal first cousins with bilateral microtia, micrognathia, cleft palate and hematologic findings of Diamond-Blackfan anemia (DBA). The similarity of findings shared between our cases and a female reported by Hasan and Inoue [1993] suggests that this is a distinctive syndrome, rather than a chance association. DBA is a heterogeneous disorder, caused in about 25% of cases by heterozygous mutations in the RPS19 gene (DBA1). Mutation analysis in our cases did not show an RPS19 mutation, and 2 alleles were present in each. Segregation analysis for DBA1 on chromosome 19 and DBA2 on 8p23 was not consistent with linkage. We conclude that this syndrome of microtia, cleft palate and DBA is not allelic to known DBA loci. 
 Question: In which syndrome is the RPS19 gene most frequently mutated?
Example Output: dba

Example Input: Context: One Shell Square is a 51-story, 697-foot (212 m) skyscraper designed in the International style by Skidmore, Owings and Merrill, located at 701 Poydras Street in the Central Business District of New Orleans, Louisiana. 
 Question: The designer for One Shell Square was?
Example Output:
skidmore, owings and merrill