Given a passage, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.

Endometrial cancers (ECs) are the most common form of gynecologic malignancy. Recent studies have reported that ECs reveal distinct markers for molecular pathogenesis, which in turn is linked to the various histological types of ECs. To understand further the molecular events contributing to ECs and endometrial tumorigenesis in general, a more precise identification of cancer-associated molecules and signaling networks would be useful for the detection and monitoring of malignancy, improving clinical cancer therapy, and personalization of treatments.', 'ECs-specific gene co-expression networks were constructed by differential expression analysis and weighted gene co-expression network analysis (WGCNA). Important pathways and putative cancer hub genes contribution to tumorigenesis of ECs were identified. An elastic-net regularized classification model was built using the cancer hub gene signatures to predict the phenotypic characteristics of ECs. The 19 cancer hub gene signatures had high predictive power to distinguish among three key principal features of ECs: grade, type, and stage. Intriguingly, these hub gene networks seem to contribute to ECs progression and malignancy via cell-cycle regulation, antigen processing and the citric acid (TCA) cycle.
Does visual gene-network analysis reveal the cancer gene co-expression in human endometrial cancer?

The main objective of this study was to analyse the outcomes after total knee arthroplasty (TKA) of a group of patients with at least one self-reported allergy and a group of patients without reported allergies. We hypothesized there is a significant negative influence on clinical outcome scores after TKA in patients with self-reported allergies.', "Four-hundred and seventy-five patients who had undergone TKA were analysed preoperatively and 1\xa0year after surgery. The WOMAC, KSS and SF-36 scores were obtained. The patients' Yesavage depression questionnaire score was also recorded. The scores of the 330 (69.5\xa0%) patients without self-reported allergies were compared to the scores of the 145 (30.5\xa0%) patients with at least one self-reported allergy in the medical record.", 'Preoperative scores were similar in both groups. The WOMAC post-operative scores (23.6 vs 20.4; p\xa0=\xa00.037) and the KSS-Knee score (91.1 vs 87.6; p\xa0=\xa00.027) were worse in the group of patients with self-reported allergies than in the group without allergies. The scores from the Yesavage depression questionnaire and in the SF-36 were similar in both groups.
Do patient-reported allergies cause inferior outcomes after total knee arthroplasty?

There is debate surrounding the use of laparoscopic resection for advanced gastric cancer in the Western population. Here we aim to assess the feasibility and short-term outcomes of laparoscopic gastrectomy in consecutive patients in a Western population.', 'From 2012 to 2014, retrospective review of 28 patients with clinically staged advanced gastric cancer (≥T3 or ≥N1) treated with laparoscopic resection.', 'Sixty-one percentage of patients were male. Median age was 67 years (range 35-86). Median BMI was 26.5 (range 19.4-46.1). Resection types were proximal (n\xa0=\xa02), distal (n\xa0=\xa014), and total (n\xa0=\xa012). Twenty-six (93\xa0%) patients underwent D2 lymphadenectomy. Four patients underwent conversion to open. Median blood loss was 125\xa0mL (range 30-300). Median LOS was 7\xa0days (range 4-16). Of postoperative complications, five were minor: arrhythmia (n\xa0=\xa01), surgical site infection (n\xa0=\xa03), in-hospital fall (n\xa0=\xa01); and four were major (intra-abdominal abscess, stricture, PE, and anastomotic bleed). T stages were Tx (n\xa0=\xa01), T2 (n\xa0=\xa03), T3 (n\xa0=\xa018), and T4 (n\xa0=\xa06). N stages were N0 (n\xa0=\xa04), N1 (n\xa0=\xa08), N2 (n\xa0=\xa01), and N3 (n\xa0=\xa015). Median tumor size was 5.8\xa0cm (range 0-9.5). Median lymph node yield was 22 (range 6-53). All margins were negative. Median follow-up was 12.8\xa0months (range 2-27). Six patients have died of progressive disease.

Is total laparoscopic resection for advanced gastric cancer safe and feasible in the Western population?