Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: Imatinib mesylate is a new drug that can inhibit the tyrosine kinase activity of Bcr-Abl, the receptors for platelet-derived growth factor receptor(PDGF) and stem cell factor, or c-kit. Chronic myeloid leukemia (CML) is distinguished by the presence of a reciprocal translocation between chromosomes 9 and 22 that results in a shortened chromosome 22, termed the Philadelphia(Ph) chromosome. As a result of the translocation, a fusion gene called the Bcr-Abl gene is created from two normal cellular genes, encoding a chimeric Bcr-Abl protein with a deregulated tyrosine kinase activity. The expression of Bcr-Abl tyrosine kinase has been shown to be necessary and sufficient for the transformed phenotype of CML cells. Imatinib can block the kinase activity of Bcr-Abl, thus inhibiting the proliferation of Ph-positive progenitors, and has shown activity against all phases of CML, though responses are most substantial and durable in patients in the chronic phase. An international phase III study which compared the efficacy of imatinib with that of interferon alpha combined with low-dose cytarabine in newly diagnosed chronic-phase CML showed the rate of major cytogenetic response at 24 months was 90%, including 82% of complete cytogenetic response. These results indicated that imatinib was superior to interferon-containing treatment as a first-line therapy. More than 10,000 patients worldwide, including those in Japan, have been treated with imatinib in clinical trials, and a lot of information has been accumulated on the use of this drug. The aim of this article is to review the use of this drug and the practical management of patients with chronic myeloid leukemia.
[A]: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


[Q]: The Patriots travelled to the Metrodome for a Monday Night Football showdown with the Minnesota Vikings, who, like the Patriots, boasted an excellent run defense. The Patriots, who took to the air with a spread offense for the entire game, opened with a seven-play, 86-yard strike that ended with a touchdown pass from Brady to wide receiver Reche Caldwell. Their next drive was for 93 yards which resulted in a 23-yard Gostkowski field goal. And just before halftime the Patriots moved 74 yards in 11 plays to take a 17-0 lead on a nine-yard scoring toss to tight end Benjamin Watson. The only Vikings score of the game came on a 71-yard punt return by Mewelde Moore in the third quarter; Laurence Maroney immediately answered on the ensuing kickoff, with a 77-yard return to Minnesota's 21-yard line, his second return of over 70 yards in as many weeks. The Patriots' lead grew to 17 after a seven-yard touchdown reception by Brown with 9:03 in the third quarter and then became 31-7 with a touchdown catch by Jackson. The Patriots defense also intercepted four passes from quarterbacks Brad Johnson and Brooks Bollinger. On Bollinger's first drive after relieving Brad Johnson he was sacked three times in a row for a net loss of 23 yards. With their fourth straight victory, the Patriots advanced to 6-1.This was the Patriots' third and final game played in the Metrodome.
[A]: Which team scored more touchdowns, the Patriots or the Vikings?


[Q]: The discovery of the Hippo pathway can be traced back to two areas of research. Genetic screens in fruit flies led to the identification of the Hippo pathway kinases and scaffolding proteins that function together to suppress cell proliferation and tumor growth. Independent research, often in the context of muscle biology, described Tead (TEA domain) transcription factors, which bind CATTCC DNA motifs to regulate gene expression. These two research areas were joined by the finding that the Hippo pathway regulates the activity of Tead transcription factors mainly through phosphorylation of the transcriptional coactivators Yap and Taz, which bind to and activate Teads. Additionally, many other signal transduction proteins crosstalk to members of the Hippo pathway forming a Hippo signal transduction network. We discuss evidence that the Hippo signal transduction network plays important roles in myogenesis, regeneration, muscular dystrophy, and rhabdomyosarcoma in skeletal muscle, as well as in myogenesis, organ size control, and regeneration of the heart. Understanding the role of Hippo kinases in skeletal and heart muscle physiology could have important implications for translational research.
[A]:
Which are the coactivators of the Yes-associated protein (yap)?