TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Does long-term treatment with methotrexate or tumor necrosis factor alpha inhibitors increase epstein-barr virus load in patients with rheumatoid arthritis?
Answer: Long-term usage of methotrexate or TNFalpha inhibitors in patients with RA does not significantly influence EBV load in PBMCs.

SOLUTION: no

PROBLEM: Question: Are antihelminthic benzimidazoles novel HIF activators that prevent oxidative neuronal death via binding to tubulin?
Answer: These studies demonstrate that tubulin-binding drugs can activate a component of the hypoxic adaptive response, specifically the stabilization of HIF-1α and its downstream targets. Tubulin-binding drugs, including antihelminthic benzimidazoles, also abrogate oxidative neuronal death in primary neurons. Given their safety in humans and known ability to penetrate into the central nervous system, antihelminthic benzimidazoles may be considered viable candidates for treating diseases associated with oxidative neuronal death, including stroke.

SOLUTION: yes

PROBLEM: Question: Is paclitaxel-induced apoptosis in non-small cell lung cancer cell lines associated with increased caspase-3 activity?
Answer: Paclitaxel induces apoptosis in lung cancer cell lines, as assessed by a consistent increase in caspase-3 activity, DNA laddering, and characteristic morphologic changes. Paclitaxel-induced apoptosis in human lung cancer cells is associated with caspase-3 activation but is not Fas dependent.

SOLUTION:
yes