Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: Sandford-on-Thames is a village and Parish Council beside the River Thames in Oxfordshire just south of Oxford.

Output: Which is the body of water by Sandford-on-Thames?


Input: Consider Input: For Fall 2018, Berkeleys acceptance rate for freshman was 15.1%. Total enrollment was 41,910 - 30,574 undergraduate and 11,336 graduate students - with women accounting for 52.7% of undergraduates and 46.2% of graduate and professional students. Of enrolled freshman, nearly 54% were women and approximately 60% self-identified as persons of color. Enrolled freshman had an average weighted secondary school GPA of 4.45 (unweighted GPA of 3.92) and had an average SAT score of 1435 (average ACT score of 32). The interquartile range for SAT scores was 1340-1530, with 660-750 for reading/writing and 670-750 for math. Berkeleys enrollment of National Merit Scholarship Program was third in the nation until 2002, when participation in the National Merit program was discontinued. For 2016-17, Berkeley ranked fifth in enrollment of recipients of the National Merit Scholarship Program (136 scholars). 33% of admitted students receive federal Pell grants.

Output: In Fall of 2018 were there more women or men enrolled as freshman?


Input: Consider Input: Accumulation and deposition of -amyloid peptides (A) in the brain is a central event in the pathogenesis of Alzheimer's disease (AD). Besides the parenchymal pathology, A is known to undergo active transport across the blood-brain barrier and cerebral amyloid angiopathy (CAA) is a prominent feature in the majority of AD. Although impaired cerebral blood flow (CBF) has been implicated in faulty A transport and clearance, and cerebral hypoperfusion can exist in the pre-clinical phase of Alzheimer's disease (AD), it is still unclear whether it is one of the causal factors for AD pathogenesis, or an early consequence of a multi-factor condition that would lead to AD at late stage. To study the potential interaction between faulty CBF and amyloid accumulation in clinical-relevant situation, we generated a new amyloid precursor protein (APP) knock-in allele that expresses humanized A and a Dutch mutation in addition to Swedish/London mutations and compared this line with an equivalent knock-in line but in the absence of the Dutch mutation, both crossed onto the PS1M146V knock-in background. Introduction of the Dutch mutation results in robust CAA and parenchymal A pathology, age-dependent reduction of spatial learning and memory deficits, and CBF reduction as detected by fMRI. Direct manipulation of CBF by transverse aortic constriction surgery on the left common carotid artery caused differential changes in CBF in the anterior and middle region of the cortex, where it is reduced on the left side and increased on the right side. However these perturbations in CBF resulted in the same effect: both significantly exacerbate CAA and amyloid pathology. Our study reveals a direct and positive link between vascular and parenchymal A; both can be modulated by CBF. The new APP knock-in mouse model recapitulates many symptoms of AD including progressive vascular and parenchymal A pathology and behavioral deficits in the absence of APP overexpression.


Output: Which disease the London mutation involved in?