Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Throughout its history, chronic myeloid leukemia (CML) has set precedents for cancer research and therapy. These range from the identification of the first specific chromosomal abnormality associated with cancer to the development of imatinib as a specific, targeted therapy for the disease. The successful development of imatinib as a therapeutic agent for CML can be attributed directly to decades of scientific discoveries. These discoveries determined that the BCR-ABL tyrosine kinase is the critical pathogenetic event in CML and an ideal target for therapy. This was confirmed in clinical trials of imatinib, with imatinib significantly improving the long-term survival of patients with CML. Continuing in this tradition of scientific discoveries leading to improved therapies, the understanding of resistance to imatinib has rapidly led to strategies to circumvent resistance. Continued studies of hematologic malignancies will allow this paradigm of targeting molecular pathogenetic events to be applied to many additional hematologic cancers.
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

A cardiovascular disease (CVD) is any disease that affects the cardiovascular system. But the term is usually used to describe diseases that are linked to atherosclerosis. Atherosclerosis ( Figure 1.1) is an inflammation of the walls of arteries that causes swelling and a buildup of material called plaque. Plaque is made of cell pieces, fatty substances, calcium, and connective tissue that builds up around the area of inflammation. As a plaque grows, it stiffens and narrows the artery, which decreases the flow of blood through the artery. Atherosclerosis normally begins in late childhood and is typically found in most major arteries. It does not usually have any early symptoms. Causes of atherosclerosis include a high-fat diet, high cholesterol, smoking, obesity, and diabetes. Atherosclerosis becomes a threat to health when the plaque buildup prevents blood circulation in the heart or the brain. A blocked blood vessel in the heart can cause a heart attack. Blockage of the circulation in the brain can cause a stroke. Ways to prevent atherosclerosis include eating healthy foods, getting plenty of exercise and not smoking. These three factors are not as hard to control as you may think. If you smoke, STOP. Start a regular exercise program and watch what you eat. A diet high in saturated fat and cholesterol can raise your cholesterol levels, which makes more plaque available to line artery walls and narrow your arteries. Cholesterol and saturated fats are found mostly in animal products such Atherosclerosis is sometimes referred to as hardening of the arteries; plaque build- up decreases the blood flow through the artery. as meat, eggs, milk, and other dairy products. Check food labels to find the amount of saturated fat in a product. Also, avoid large amounts of salt and sugar. Be careful with processed foods, such as frozen dinners, as they can be high in fat, sugar, salt and cholesterol. Eat lots of fresh or frozen fruits and vegetables, smaller portions of lean meats and fish, and whole grains such as oats and whole wheat. Limit saturated fats like butter, instead choose unsaturated vegetable oils such as canola oil. Like any other muscle, your heart needs oxygen. Hearts have arteries that provide oxygen through the blood. They are known as coronary arteries. Coronary heart disease is the end result of the buildup of plaque within the walls of the coronary arteries. Coronary heart disease often does not have any symptoms. A symptom of coronary heart disease is chest pain. Occasional chest pain can happen during times of stress or physical activity. The pain of angina means the heart muscle fibers need more oxygen than they are getting. Most people with coronary heart disease often have no symptoms for many years until they have a heart attack. A heart attack happens when the blood cannot reach the heart because a blood vessel is blocked. If cardiac muscle is starved of oxygen for more than roughly five minutes, it will die. Cardiac muscle cells cannot be replaced, so once they die, they are dead forever. Coronary heart disease is the leading cause of death of adults in the United States. The image below shows the way in which a blocked coronary artery can cause a heart attack and cause part of the heart muscle to die ( Figure 1.2). Maybe one day stem cells will be used to replace dead cardiac muscle cells. Atherosclerosis in the arteries of the brain can also lead to a stroke. A stroke is a loss of brain function due to a blockage of the blood supply to the brain. Risk factors for stroke include old age, high blood pressure, having a previous stroke, diabetes, high cholesterol, and smoking. The best way to reduce the risk of stroke is to have low blood pressure.
what is atherosclerosis?

You have been badly injured in a car accident. It is necessary to give you a blood transfusion because you lost a great deal of blood in the accident. However, special care must be taken in selecting new blood for you. If the blood is too different from your own, the transfusion could kill you. There are four basic types of blood; A, B, AB, and O. A simple test can make sure of a person's blood type. Everybody is born with one of these four types of blood. Blood type, like hair color1 and height, is received from parents. The four groups must be transfused carefully. A and B cannot be mixed. A and B cannot receive AB, but AB may receive A or B. O can give to any other group; therefore, it is often called the universal donor . For the opposite reason, AB is sometimes called the universal recipient . However, because so many reactions can happen in transfusions , patients usually receive only salt of plasma (liquid part of blood) until their blood can be matched as exactly as possible in the blood bank of a hospital. In this way, it is possible to prevent the transfusion from any bad reactions.

People with type A blood can receive type     .