TASK DEFINITION: Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
PROBLEM: Context: The film opens with an animated prologue revealing the origins of leprechauns, stating that they were summoned by a king to protect his gold from those who would try to steal it. After the death of the king the Leprechauns returned to their places of origin, all except one (Warwick Davis) who remained in the mortal world and through the ages slowly became corrupted and obsessed with the treasure he still guarded. In the present Father Jacob (Willie C. Carpenter) is chased through the construction site of the youth center he had planned on building by the Leprechaun, whose gold Jacob had taken to fund the building project. Using four-leaf clover laced holy water Jacob manages to banish the Leprechaun, summoning demonic hands which drag him underground, but soon after drops dead of injuries inflicted by the Leprechaun during the fight.One year later two down on their luck friends Emily Woodrow (Tangi Miller) and Lisa Duncan (Sherrie Jackson) have their fortune told when the clairvoyant Esmeralda (Donzaleigh Abernathy) who warns them that they will attain great wealth soon, but it must be denied as it will come at a great price and summon a terrible evil. While having a barbecue at the abandoned youth center construction site with Lisa, their stoner friend Jamie Davis (Page Kennedy) and her ex-boyfriend turned drug dealer Rory Jackson (Laz Alonso) Emily falls through a hole and discovers the Leprechaun's gold in an old tunnel where it was hidden by Father Jacob. Splitting up the gold (which is produced in a never ending amount by the chest it was contained in) evenly the quartet of friends use it to fulfill their fantasies, unaware that by taking the gold they have released the Leprechaun, who begins stalking the group (killing a guest who takes one of his coins at a party held by Jamie, prompting the police to temporarily arrest him). At the salon where Emily works the Leprechaun sneaks in and, after killing a regular customer, Doria, on the massage table by breaking her neck, attacks Emily, who barely escapes and warns Rory and the recently released Jamie, who rush to get to Lisa's. In her house Lisa is attacked by the Leprechaun and manages to fight him off for a short while, but is killed when the Leprechaun claws her in the stomach, with her friends finding her body moments later.While Emily and Jamie want to return the gold Rory does not and takes off with it; shortly after realizing Rory is gone Emily is attacked and chased outside by the Leprechaun, but is saved when Rory has a change of heart and comes back for her. Searching for Rory the Leprechaun stops by his house and kills Rory's profligate girlfriend Chanel (Keesha Sharp) by tearing out her upper jaw, reclaiming the gold she used to make a tooth while Rory and Emily are stopped and harassed by Officers Thompson (Beau Billingslea) and Whitaker (Chris Murray). After the Leprechaun appears and kills the two officers Emily and Rory escape and regroup with Jamie, only to be confronted by a machine gun wielding group of Rory's drug dealing rivals, led by Watson (Shiek Mahmud-Bey) and Cedric (Sticky Fingaz). Planning on executing Rory for infringing on their territory Watson and his gang are all disposed of by the Leprechaun, (who kills Watson and Cedric while the other two members run off) while Emily, Rory and Jamie drive off in Watson's car (which the Leprechaun latches to the bottom of for a short while) and go looking for help from Esmeralda.Advised to use four-leaf clovers against the Leprechaun by Esmeralda, Rory laces the hollow-point bullets of his gun with clovers Jamie finds in the marijuana Rory had earlier sold him. When the Leprechaun arrives Rory shoots him several times with the clover bullets, only for his gun to jam before he can finish the Leprechaun off. Rory and Emily are given the chance to run with the gold when the Leprechaun is distracted by Jamie and Esmeralda (the latter dying in a magical duel with the Leprechaun). Followed to the roof of the building Rory tries fighting the Leprechaun and is knocked out, though before the Leprechaun can kill him 
 Question: Why does a machine gun wielding group of Rory's drug-dealing rivals confront the group?

SOLUTION: planning on executing rory for infringing on their territory

PROBLEM: Context: In the Caucasus region of Russia, nearly 50 out of every 100,000 people live to celebrate their 100th birthday, and many don't stop at 100! By comparison, in America only 3 people in 100,000 reach 100. But these Russian old people aren't alone. The Pakistanis, who live high in the Himalaya Mountains, and the Ecuadorans of the Andes Mountains seem to share the secret of long life, too. These people remain healthy in body and spirit despite the passage of time. While many older persons in industrial societies become weak and ill in their 60s and 70s, some Caucasians aged 100 to 140, work in the fields beside their great-great-grandchildren. Even the idea of aging is foreign to them. When asked "at what age does youth end?"most of these old people had no answer. Several replied, "Well, perhaps at age 80." What accounts for this ability to survive to such old age, and to survive so well?First of all, hard physical work is a way of life for all of these long-lived people. They begin their long days of physical labor as children and never seem to stop. For example, Mr . Rustam Mamedov is 142 years of age. His wife is 116 years old. They have been married for 90 years. Mr. Mamedov has no intention of retiring from his life as a farmer. "Why?What else would I do?"he asks. All these people get healthful rewards from the environment in which they work. They all come from mountainous regions. They live and work at elevations of 1,660 to 1,000 meters above sea level. The air has less oxygen and is pollution-free. This reduced-oxygen environment makes the heart and blood vessel system stronger. Another factor that may contribute to the good health of these people is their isolation. To a great extent, they are separated from the pressures and worries of industrial society. Inherited factors also play some role. Most of the longest-lived people had parents and grandparents who also reached very old ages. Good family genes may, therefore, be one factor in living longer. 
 Question: What is the main way of life for all of these long-lived people?

SOLUTION: hard physical work.

PROBLEM: Context: CML (chronic myeloid leukaemia) is a myeloproliferative disease that originates in an HSC (haemopoietic stem cell) as a result of the t(9;22) translocation, giving rise to the Ph (Philadelphia chromosome) and bcr-abl oncoprotein. The disease starts in CP (chronic phase), but as a result of genomic instability, it progresses over time to accelerated phase and then to BC (blast crisis), becoming increasingly resistant to therapy. bcr-abl is a constitutively active tyrosine kinase that has been targeted by TKIs (tyrosine kinase inhibitors), including IM (imatinib mesylate), nilotinib and dasatinib. We have developed various flow cytometry techniques to enable us to isolate candidate CML stem cells from CP patients at diagnosis that efflux Hoechst dye, express CD34, lack CD38 and are cytokine-non-responsive in culture over periods of up to 12 days in growth factors. These stem cells have been shown to regenerate bcr-abl-positive haemopoiesis in immunocompromised mice upon transplantation. We previously demonstrated that IM was antiproliferative for CML stem cells but did not induce apoptosis. Clinical experience now confirms that IM may not target CML stem cells in vivo with few patients achieving complete molecular remission and relapse occurring rapidly upon drug withdrawal. Our recent efforts have focused on understanding why CML stem cells are resistant to IM and on trying to find novel ways to induce apoptosis of this population. We have shown that CML stem cells express very high levels of functional wild-type bcr-abl; no kinase domain mutations have been detected in the stem cell population. Dasatinib, a more potent multitargeted TKI than IM, inhibits bcr-abl activity more efficiently than IM but still does not induce apoptosis of the stem cell population. Most recently, we have tested a number of novel drug combinations and found that FTIs (farnesyl transferase inhibitors) have activity against CML. BMS-214662 is the most effective of these and induces apoptosis of phenotypically and functionally defined CML stem cells in vitro, as a single agent and in combination with IM or dasatinib. The effect against CML stem cells is selective with little effect on normal stem cells. The drug is also effective against BC CML stem cells and equally effective against wild-type and mutant bcr-abl, including the most resistant mutant T315I. In association with apoptosis, there is activation of caspase 8 and caspase 3, inhibition of the MAPK pathway, IAP-1 (inhibitor of apoptosis protein-1), NF-kappaB (nuclear factor kappaB) and iNOS (inducible nitric oxide synthase). Furthermore, BMS-214662 synergizes with MEK1/2 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 1/2] inhibitors, suggesting a second mechanism other that RAS inhibition for induction of apoptosis. Our intentions are now to explore the activity of BMS-214662 in other cancer stem cell disorders and to move this preclinical work to a clinical trial combining dasatinib with BMS-214662 in CML. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

SOLUTION:
bcr-abl