Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Ex Input:
We report a case of acne fulminans occurring during treatment with 13-cis-retinoic acid for cystic acne.

Ex Output:
adverse drug event


Ex Input:
Specifically, for children with a family history of gallbladder, biliary tract, liver or pancreas dysfunction, ceftriaxone may not be the drug of choice since the likelihood of complications is increased in this population.

Ex Output:
non-adverse drug event


Ex Input:
To the best of our knowledge, this is the first report of an association between sunitinib and gynaecomastia.

Ex Output:

non-adverse drug event