Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Context: In 2000, the label moved from Brussels to London and was renamed PIAS Recordings. 
 Question: What city is the band PIAS Recordings from?
brussels

Context: Change in gene expression associated with pancreatic cancer could be attributed to the variation in histone posttranslational modifications leading to subsequent remodeling of the chromatin template during transcription. However, the interconnected network of molecules involved in regulating such processes remains elusive. hPaf1/PD2, a subunit of the human PAF-complex, involved in the regulation of transcriptional elongation has oncogenic potential. Our study explores the possibility that regulation of histone methylation by hPaf1 can contribute towards alteration in gene expression by nucleosomal rearrangement. Here, we show that knockdown of hPaf1/PD2 leads to decreased di- and tri-methylation at histone H3 lysine 4 residues in pancreatic cancer cells. Interestingly, hPaf1/PD2 colocalizes with MLL1 (Mixed Lineage Leukemia 1), a histone methyltransferase that methylates H3K4 residues. Also, a reduction in hPaf1 level resulted in reduced MLL1 expression and a corresponding decrease in the level of CHD1 (Chromohelicase DNA-binding protein 1), an ATPase dependent chromatin remodeling enzyme that specifically binds to H3K4 di and trimethyl marks. hPaf1/PD2 was also found to interact and colocalize with CHD1 in both cytoplasmic and nuclear extracts of pancreatic cancer cells. Further, reduced level of CHD1 localization in the nucleus in hPaf1/PD2 Knockdown cells could be rescued by ectopic expression of hPaf1/PD2. Micrococcal nuclease digestion showed an altered chromatin structure in hPaf1/PD2-KD cells. Overall, our results suggest that hPaf1/PD2 in association with MLL1 regulates methylation of H3K4 residues, as well as interacts and regulates nuclear shuttling of chromatin remodeling protein CHD1, facilitating its function in pancreatic cancer cells. 
 Question: Which is the histone residue methylated by MLL1?
h3k4

Context: Water is simply two atoms of hydrogen and one atom of oxygen bonded together (Figure 1.1). The hydrogen ions are on one side of the oxygen ion, making water a polar molecule. This means that one side, the side with the hydrogen ions, has a slightly positive electrical charge. The other side, the side without the hydrogen ions, has a slightly negative charge. Despite its simplicity, water has remarkable properties. Water expands when it freezes, has high surface tension (because of the polar nature of the molecules, they tend to stick together), and others. Without water, life might not be able to exist on Earth and it certainly would not have the tremendous complexity and diversity that we see. Water is the only substance on Earth that is present in all three states of matter - as a solid, liquid or gas. (And Earth is the only planet where water is abundantly present in all three states.) Because of the ranges in temperature in specific locations around the planet, all three phases may be present in a single location or in a region. The three phases are solid (ice or snow), liquid (water), and gas (water vapor). See ice, water, and clouds (Figure 1.2). (a) Ice floating in the sea. Can you find all three phases of water in this image? (b) Liquid water. (c) Water vapor is invisible, but clouds that form when water vapor condenses are not. Click image to the left or use the URL below. URL: 
 Question: hydrogen atoms have this kind of charge.

positive