Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein tau. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds tau with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the tau-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10(-9) M MAP2c and 10(-8) M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and tau might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease.

Answer: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?


Question: This busy and popular hotel requires a Junior Chef. You will need to be energetic, enthusiastic with a minimum of five years' kitchen experience. You must assist the head and senior chefs in the creation of new dishes. Annual salaries range from 20,000 to 25,000 pounds. Please send or e-mail your CV to the Personnel Administrator Hydo Hotel, Mount Road Eastbourne BN207HZ eclaine.ward@hydrohotel.com. We are looking for a kitchen assistant willing to learn the day-to-day jobs in a professional kitchen environment. You must have a passion for cooking and basic understanding of spoken English. You will mainly be working for a well-known company and learn valuable cheffing skills. The salary will be based on experience but could start from 12,500 pounds to 14,000 pounds annually plus tips. Please forward your CV and a letter of recommendation. 01428644460 Kitchen Manager. Spirit Pub Company is looking for the best individuals to lead our kitchen teams through some very exciting new developments. As an experienced Kitchen Manager, you will play an important role in engaging the chef team by great leaderships to deliver excellent standards and guest satisfaction. We can offer a starting salary of up to 27,000 pounds plus a bonus worth an extra 2,000 pounds per year for the right candidates. If you have what it takes to join our company, please provide your CV with your application. 07044338313 Food Service Assistant, South East Food Service Assistant required. Salary starts from 15,000 pound to 20,000 pounds annually. We are seeking a General Assistant for a Care Home East Sussex. Assisting the Cook and kitchen team in the food preparation of freshly prepared meals, washing up and cleaning of all kitchen areas. Previous experience would be an advantage. 07044338228

Answer: Which job probably offers the second highest salary?


Question: Probe-to-bone test and simple X-rays are both standard tests for the diagnosis of diabetic foot osteomyelitis. This study demonstrates the importance of considering jointly clinical information (probe-to-bone test) and diagnostic tests (simple radiography) to increase agreement among clinicians on diagnosis of diabetic foot osteomyelitis.

Answer:
Which disease can be diagnosed with the "probe to bone" test?