Generate an explanation for the given claim using the provided supporting material from the paragraph. Please consider the following points while generating an output. 1) The claim will always have supporting proof in the paragraph, and the paragraph will have a clear point of view supporting the claim. 2) There can be instances where direct correlation to the claim is not available. Make use of the sentences in the paragraph to provide a corresponding output supporting the claim. 3) The explanation should be at least one and at most twelve sentences long.

[EX Q]: Paragraph: Although the release doesn’t give actual costs of warfarin versus some of the newer drugs, or factor in the cost of the usual monthly blood testing required of those taking the drug, it does note the cost of the gene testing used for the study, and that the $200 price tag is now less than a month’s prescription of one of the newer anti-coagulants on the market. The release gives results in both actual numbers of patients and the percentage of reduction of adverse events in those given the genetic test and a comparison group. Although it does so in general terms, the release covers the essentials: the risk of using blood thinners like warfarin and the risks of not using them. The release offers a good description of the design of the study. It was randomized and enrolled more than 1,600 older patients at high risk of blood clots following surgeries. The release explains that one group received warfarin dosing based on standard factors (age, height and weight) and the second group was dosed using these clinical factors plus their genetic variants. The release also offers a detailed breakdown on how many fewer side effects occurred among patients had genetic testing completed compared to those who didn’t. No mongering here. Nicely done and quite complete. Although the release briefly mentions the availability of a “newer anticoagulant,” it should have included a sentence or two about these newer injectable drugs and their overall risks and benefits in comparison to warfarin. It would also have been helpful to tell readers whether the genetic testing that appears to play a role in safer warfarin dosing would have clinical relevance for informing the use of the new blood thinners as well. The fact is that genetic testing is irrelevant for the newer anti-coagulants because they operate in a completely different manner. But all the blood thinners — old and new — carry the same risk of bleeding. The problem with warfarin is the variability in blood levels which requires frequent monitoring, hence the genetic tests to guide dosing. The careful reader will get it: testing for these genetic variants is still an experimental practice for the most part, and further testing of how the mutations affect warfarin is needed. But the release could have been more explicit in saying that no one is yet recommending genetic testing for millions of warfarin users. While the genetic tests are “available” in the sense that anyone can order them for the most part, they are not routinely used clinically and probably wouldn’t be covered by insurance so in that sense they are not widely available to most people. The release describes how the genetic test used in the new study differs from previous similar studies. Overall the language is careful and contextual. The headline should have been toned back a bit to note that this is early research and more study is needed before concluding that “Genetic testing helps set safe dose of common blood thinner,” as the headline now states. Claim: Genetic testing helps set safe dose of common blood thinner
[EX A]: This news release describes results of a study designed to learn whether testing for the presence of three gene variants could make dosing with the blood thinner warfarin safer for patients given the drug to prevent blood clots after joint replacement surgery. The study found a modest reduction in the risk of bleeding or clots (from over- or under-dosing) in those whose regimens were developed in part by genetic testing for the variants, compared to those whose doses were calculated without the genetic testing. The release does an overall good job in describing the study, its purpose and design; and in quantifying the results. It could have been even stronger if it had included more information about newer alternatives to warfarin that are growing in use and an explicit statement that no one is yet recommending routine genetic testing for the variants based on this study. And although the headline somewhat over promises clinical benefit at this point in time, thoughtful readers will come away with a decent understanding of the context of the research and its potential impact. Some estimates put the number of Americans regularly taking the clot-preventing blood thinner warfarin and several newer anticoagulants at more than six million. Warfarin (sold under the brand name Coumadin) requires frequent blood testing to address risks of overdoses (and potentially lethal bleeding) and under-dosing (ineffective prevention of strokes and other blood clots). Because warfarin is cheap, and its effects are reversible with vitamin K, research designed to make it easier and safer for patients to take is likely to be highly newsworthy for them and their caregivers.

[EX Q]: Paragraph: A nurse extracts a vaccine in a file photo. Federal health officials said on Thursday the government has not conceded that vaccines cause autism even after a Georgia girl won federal compensation in a case arguing a vaccine led to her brain damage. REUTERS/Phil Klein  Hannah Poling, 9, had a rare mitochondrial disorder and a  federal court ruling said regular childhood vaccinations may  have contributed to some of her autism-like symptoms. She was  awarded compensation under the National Vaccine Injury  Compensation Program in a case that became public this week. Some activists who argue vaccines can trigger autism jumped  on the case as vindication of their cause. But Dr. Julie  Gerberding, director of the U.S. Centers for Disease Control  and Prevention, denied this. “Let me be very clear that (the) government has made  absolutely no statement about indicating that vaccines are a  cause of autism,” Gerberding told reporters in a telephone  briefing. “That is a complete mischaracterization of the findings of  the case, and a complete mischaracterization of any of the  science that we have at our disposal today. So I think we need  to set the record straight on that.”    The vaccine injury program is a no-fault system that has a  $2.5 billion fund built up from a 75-cent-per-dose tax on  vaccines. It was set up to ensure companies would not be afraid  to make vaccines, and to provide injured children an easier way  to seek compensation. Thousands of lawsuits have been filed by parents who argue  their children have autism caused by vaccines. The Institute of Medicine, an independent organization set  up to inform U.S. policy, has found there is no evidence that  vaccines can cause autism. Many recent studies have come to the  same conclusion. Some autism advocacy groups argue that a mercury-containing  preservative in vaccines called thimerosal can cause autism. Republican presidential candidate Sen. John McCain entered  the debate last week, saying there is “strong evidence” linking  autism to a thimerosal. Dr. Edwin Trevathan, director of the CDC’s National Center  on Birth Defects and Developmental Disabilities, said the  Poling case did not demonstrate any link between vaccines and  autism. “I think it’s also worth noting that most children with  autism do not seem to have a mitochondrial problem,” he told  the briefing. “So this association between mitochondrial disorders and  autism is actually probably relatively rare. But the  association between mitochondrial disorders and severe brain  damage and dysfunction is one that is not as rare and is  actually quite important.”    Trevathan said it is not clear whether a fever caused by a  vaccine might further stress a child with such a condition,  causing autism-like symptoms. Autism can have relatively mild symptoms or can severely  disable a child by interfering with speech and behavior. No one  knows what causes it. The CDC estimates that about one in every 150 children has  autism or a related disorder such as Asperger’s syndrome —  560,000 people up to age 21 in the United States. “Our message to parents is that immunization is  life-saving. There’s absolutely nothing changed in the adamant  recommendations that we are making to get children vaccinated,”  Gerberding said. Claim: Still no autism-vaccine link, say health officials.
[EX A]: Federal health officials said on  Thursday the government has not conceded that vaccines cause  autism even after a Georgia girl won federal compensation in a  case arguing a vaccine led to her brain damage.

[EX Q]: Paragraph: The 78-year-old TV personality tells People magazine he’s responding very well to chemotherapy and the doctors have told him “they hadn’t seen this kind of positive results in their memory.” Trebek says some of the tumors have shrunk by more than 50%. Trebek announced his diagnosis in March, but said he intended to keep working. He said he planned to beat the disease’s low survival rate with the love and support of family and friends and with prayers from viewers. The American Cancer Society estimates 3% of patients with stage 4 pancreatic cancer are alive 5 years after being diagnosed. Trebek says he still has several more rounds of treatment to hopefully get into full remission. Claim: Alex Trebek shares ‘mind-boggling’ pancreatic cancer update.
[EX A]:
“Jeopardy!” host Alex Trebek says his doctors say he’s in “near remission” of advanced pancreatic cancer and his response to the treatment is “kind of mind-boggling.”