Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Ex Input:
Amphotericin B nephrotoxicity in humans decreased by salt repletion.

Ex Output:
adverse drug event


Ex Input:
Septic knee arthritis after intra-articular hyaluronate injection.

Ex Output:
adverse drug event


Ex Input:
This unusual pattern of low-grade endometrial carcinoma adds to the spectrum of uterine neoplasia associated with tamoxifen therapy.

Ex Output:

adverse drug event