Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

Q: Question: Does toll-like receptor 4 signaling contribute to Paclitaxel-induced peripheral neuropathy?
Answer: The toll-like receptor TLR4 and MyD88 signaling pathway could be a new potential therapeutic target in paclitaxel-induced painful neuropathy.

A: yes
****
Q: Question: Does preinjury beta blocker usage affect the heart rate response to initial trauma resuscitation?
Answer: Preinjury beta blockade is associated with a slower presenting heart rate, more bradycardia, less tachycardia, but no difference in mortality or ability to achieve a normal heart rate with resuscitation.

A: no
****
Q: Question: Does simvastatin influence the intestinal P-glycoprotein and MPR2 , and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1 , ABCC2 and SLCO1B1 polymorphisms?
Answer: Simvastatin does not influence the intestinal expression of P-gp and MRP2 in man. There was no pharmacokinetic interaction between talinolol and simvastatin during their chronic co-administration to healthy subjects.

A:
no
****