Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.
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Question: Hemoglobin electrophoresis and methemoglobin reductase determinations were normal for age.

Answer: non-adverse drug event


Question: Intravenous injection of diazepam caused a rapid normalization of the EEG with disappearance of the clinical manifestations.

Answer: non-adverse drug event


Question: We report a case of biopsy-proven acute tubulointerstitial nephritis associated with a second course of flurbiprofen, a nonsteroidal anti-inflammatory drug of the propionic acid class.

Answer:
adverse drug event