Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

Q: Question: Does cognitive impairment in patients with multiple sclerosis predict worse caregiver 's health-related quality of life?
Answer: MS patients' caregivers' HRQoL is significantly influenced by information processing speed impairment of MS patients.

A: yes
****
Q: Question: Does δNp63α enhance the oncogenic phenotype of osteosarcoma cells by inducing the expression of GLI2?
Answer: Here, we report that GLI2 is the novel target gene of ΔNp63α and that ΔNp63α-GLI2 crosstalk in osteosarcoma cells is a necessary event in osteosarcoma progression. Defining the exact mechanisms involved in this interaction that mediate the pathogenesis of osteosarcoma promises to identify targets for drug therapy.

A: yes
****
Q: Question: Is the systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber independent of age and body size?
Answer: The systemic exposure to the active ingredients of a fixed dose combination of beclometasone/formoterol administered via pMDI with AeroChamber Plus™ correlates with the nominal dose independently of patient age and body size. Thus, dose reduction in relation to age when using a pMDI with VHC may be unnecessary for reducing the systemic exposure in children.

A:
yes
****