Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
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Question: Question: Is the G-308A variant of the Tumor Necrosis Factor-alpha ( TNF-alpha ) gene associated with obesity , insulin resistance and body fat distribution?
Answer: Our study did not detect any significant association of the G-308A TNFalpha polymorphism with obesity or with its clinical and metabolic abnormalities in this population. Our data suggests that, in our population, the G-308A TNFalpha polymorphism is unlikely to play a major role in the pathogenesis of these conditions.

Answer: no


Question: Question: Does a null mutation in ANGPTL8 associate with either plasma glucose or type 2 diabetes in humans?
Answer: Disruption of ANGPTL8 function in humans does not seem to have a large effect on measures of glucose tolerance.

Answer: no


Question: Question: Are overweight and obesity in old age associated with greater dementia risk?
Answer: Older persons with higher BMI scores have less dementia risk than their counterparts with lower BMI scores. High BMI scores in late life should not necessarily be considered to be a risk factor for dementia.

Answer:
no