Given a text passage, come up with an appropriate title for it. The title should accurately represent what the main focus of the passage is. The title of a passage may be present in the first few sentences of the passage and/or be referred to multiple times in the passage. The title should be 1-5 words long.
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Question: Transition state analogs ( transition state analogues ) , are chemical compounds with a chemical structure that resembles the transition state of a substrate molecule in an enzyme - catalyzed chemical reaction . Enzymes interact with a substrate by means of strain or distortions , moving the substrate towards the transition state . Transition state analogs can be used as inhibitors in enzyme - catalyzed reactions by blocking the active site of the enzyme . Theory suggests that enzyme inhibitors which resembled the transition state structure would bind more tightly to the enzyme than the actual substrate . Examples of drugs that are transition state analog inhibitors include flu medications such as the neuraminidase inhibitor oseltamivir and the HIV protease inhibitors saquinavir in the treatment of AIDS .

Answer: Transition state analog


Question: In Greek mythology , Icarus ( the Latin spelling , conventionally adopted in English ; Ancient Greek : Ἴκαρος , Íkaros , Etruscan : Vikare ) is the son of the master craftsman Daedalus , the creator of the Labyrinth . Icarus and his father attempt to escape from Crete by means of wings that his father constructed from feathers and wax . Icarus ' father warns him first of complacency and then of hubris , asking that he fly neither too low nor too high , so the sea 's dampness would not clog his wings or the sun 's heat melt them . Icarus ignored his father 's instructions not to fly too close to the sun ; when the wax in his wings melted he tumbled out of the sky and fell into the sea where he drowned , sparking the idiom `` do n't fly too close to the sun '' .

Answer: Icarus


Question: The St Ives Bay Line is a 4.25 miles ( 6.84 km ) railway line from St Erth to St Ives in Cornwall , England , United Kingdom . It was opened in 1877 , the last new 7 ft ( 2,134 mm ) broad gauge passenger railway to be constructed in the country . Converted to standard gauge in 1892 , it continues to operate as a community railway which carries a large number of tourists as well as local passengers . It has five stations including the junction with the Cornish Main Line at St Erth .

Answer:
St Ives Bay Line