Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Q: Context: A rock is a naturally formed, non-living Earth material. Rocks are made of collections of mineral grains that are held together in a firm, solid mass (Figure 1.1). How is a rock different from a mineral? Rocks are made of minerals. The mineral grains in a rock may be so tiny that you can only see them with a microscope, or they may be as big as your fingernail or even your finger (Figure Rocks are identified primarily by the minerals they contain and by their texture. Each type of rock has a distinctive set of minerals. A rock may be made of grains of all one mineral type, such as quartzite. Much more commonly, rocks are made of a mixture of different minerals. Texture is a description of the size, shape, and arrangement of mineral grains. Are the two samples in Figure 1.3 the same rock type? Do they have the same minerals? The same texture? The different colors and textures seen in this rock are caused by the presence of different minerals. A pegmatite from South Dakota with crystals of lepidolite, tourmaline, and quartz (1 cm scale on the upper left). Sample 2 Crystals are tiny or microscopic Magma erupted and cooled quickly Andesite As seen in Table 1.1, these two rocks have the same chemical composition and contain mostly the same minerals, but they do not have the same texture. Sample 1 has visible mineral grains, but Sample 2 has very tiny or invisible grains. The two different textures indicate different histories. Sample 1 is a diorite, a rock that cooled slowly from magma (molten rock) underground. Sample 2 is an andesite, a rock that cooled rapidly from a very similar magma that erupted onto Earths surface. A few rocks are not made of minerals because the material they are made of does not fit the definition of a mineral. Coal, for example, is made of organic material, which is not a mineral. Can you think of other rocks that are not made of minerals? Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL: 
 Question: _______________________ is a naturally formed, non-living earth material.

A: rock
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Q: Context: The Islands of Hawaii Hawaii The "Big Island" of Hawaii is a paradise playground where visitors can enjoy a popular lifestyle and at the same time, witness the attraction of nature: thousands of square miles form a wonderland, featuring breathtaking beaches, forests, snow-covered mountains and amazing active volcanoes. A visit to Volcanoes National Park, which has been described as a true wonder of the world, is a must. It is the state's biggest attraction. Accommodations Seasons Resort Hualalai from $ 205.00Fairmont Orchid: from $108.00 Sightseeing and Experiences Circle Island Tour: from $48.00 Kauai The beautiful landscape of Kauai has led to it being called the "Garden Isle", but it is also referred to as the "Island of discovery", and with good reason - a land of striking natural contrasts just waiting to be explored. Green mountains, a breathtaking coastline and white sand beaches combine to make it one of the world's most relaxing locations. Accommodations Grand Hyatt Kauai: from $ 101.00Sheraton Kauai Resort: from $ 79.00 Maui Voted the "World's Best Island", Maui is widely regarded as one of the most romantic destinations on earth. It is known as the "Valley Isle" and was the ancient playground for Hawaiian royalty. The island is largely rural with a small and wonderful population and a host of attractions and nature wonders. Accommodations Hyatt Regency Maui Resort & Spa: from $ 87.00 Sheraton Maui: from $ 99.00 Oahu Oahu has a unique rhythm, filling the air with sweet fragrances , music and language: from lovely beaches and amazing nightlife to beautiful rainforests and quiet valleys. Adventure, history, romance, discovery--Oahu waits for you. Accommodations Halekulani: from $ 121.00 Hilton Hawaiia: Village: from $ 73.00 Sightseeing and Experiences Royal Circle Island Tour: from $ 34.00 Paradise Cove Lu'au: $ 44.00 # All prices are based on per person per night. 
 Question: Which island was the ancient playground for Hawaiian royalty?

A: maui
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Q: Context: Chronic myeloid leukemia (CML) is caused by Bcr-Abl, a constitutively active tyrosine kinase that is the result of a reciprocal translocation between chromosomes 9 and 22 and cytogenetically evident as the Philadelphia chromosome. Imatinib (Glivec, Gleevec), a specific small molecule inhibitor of Bcr-Abl, has become the standard drug therapy for CML, and has dramatically diminished the use of allogeneic stem cell transplantation. Despite unprecedented rates of complete cytogenetic response, residual disease remains detectable in the majority of patients, suggesting that imatinib fails to eradicate leukemic stem cells. In this publication, the current perspectives for CML patients treated with imatinib are reviewed, focusing on the results of both standard and high-dose therapy. Monitoring of time-dependent prognostic factors is reviewed. The reasons imatinib may not be able to eradicate the disease are discussed, and potential strategies to achieve disease elimination are presented. Lastly, resistance to imatinib and the potential of second-generation Abl kinase inhibitors in the setting of clinical resistance are considered. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

A:
bcr-abl
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