Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.

[Q]: The Sackler family owns Purdue Pharma, the privately held drug company that has made billions from OxyContin, and Sacklers hold most of the seats on the board. Members of the family have been accused in a case brought by the state of Massachusetts of deceiving patients and doctors about the drug’s risks as deaths mounted. And documents recently released in the case shine new light on former Purdue Pharma President Richard Sackler’s role in the aggressive marketing of the powerful opioid. As the allegations mount, family members who made their fortunes well before OxyContin even went on the market have sought to distance themselves from their relatives. At the same time, activists have called on institutions to cut ties with the Sacklers, staging protests at museums that have received millions in donations. “The Sackler name is becoming synonymous with the opioid epidemic, and it is damning for these institutions to have their name up,” said Nan Goldin, a photographer whose works have been displayed at Harvard’s Arthur M. Sackler Museum and at New York’s Metropolitan Museum of Art, which has a Sackler Wing. Lost in the outrage: One of the most generous and best known of the Sacklers died in 1987, nearly a decade before OxyContin was released. Arthur M. Sackler made his money from medical research, medical advertising and trade publications. His younger brothers, Raymond and Mortimer, bought out his stake after he died. Arthur Sackler’s name is on a gallery at the Smithsonian, a wing of galleries at London’s Royal Academy of Arts and a museum at Beijing’s Peking University. The Sackler Wing at the Met, which houses the celebrated Temple of Dendur from ancient Egypt, was funded by all three brothers. Richard has likewise donated heavily to various institutions. After a federal investigation, Purdue Pharma and three executives — none of them Sacklers — pleaded guilty in 2007 and agreed to pay more than $600 million for misleading the public about the risks of OxyContin. The Stamford, Connecticut, company has also been hit with a multitude of lawsuits over its role in the opioid crisis that killed more than 47,000 people in 2017 alone. Arthur’s nephew, Richard Sackler, who became president of Purdue Pharma in 1999 and remains on the board, is at the center of the litigation. He and other current and former executives have been accused of hiding the dangers of the drug from doctors and patients, encouraging physicians to prescribe more of the highest doses and minimizing the abuse crisis as it was unfolding. “This is not too bad. It could have been far worse,” he wrote to Purdue Pharma executives in 2001 after a federal prosecutor reported that 59 people in one state had died from OxyContin, according to documents released this week in the Massachusetts case. At the launch party for OxyContin in 1996, Richard Sackler boasted the drug would bring a “blizzard of prescriptions that will bury the competition,” the documents say. Years later, they say, he sought to shift blame onto drug users themselves, recommending the company “hammer on the abusers in every way possible.” “Richard followed that strategy for the rest of his career: collect millions from selling addictive drugs, and blame the terrible consequences on the people who became addicted,” attorneys in Massachusetts Attorney General Maura Healey’s office wrote. “By their misconduct, the Sacklers have hammered Massachusetts families in every way possible. And the stigma they used as a weapon made the crisis worse.” A spokesman for Richard Sackler’s family referred questions about the lawsuit to the company. Purdue Pharma said in a statement that Massachusetts’ case — the first one brought by a state to personally name members of the Sackler family — is “littered with biased and inaccurate characterizations.” The company said it will “aggressively defend against these misleading allegations.” Arthur Sackler’s widow and children insist that they never financially benefited from the sale of OxyContin. “It is a gross injustice to connect Arthur to the opioid crisis some 30 years after his death when he had nothing to do with it,” Dame Jillian Sackler said in a statement. “It denies the many important contributions he made working to improve world health and to build cultural bridges between peoples.” But activists have made no distinction between Arthur and his relatives. In July, dozens of activists led by Goldin held a protest inside the Arthur M. Sackler Museum at Harvard, scattering pill bottles and holding banners that read “SHAME ON SACKLER.” Similar demonstrations have been held at the Met and the Smithsonian. Goldin, who was addicted OxyContin for years, said that getting the institutions to act will be difficult. “Who is going to turn down the money? They offer millions to these institutions, and the board members are not necessarily committed to action, so it’s going to take a lot,” she said. A Met spokesman said that the Sackler family’s support began decades before the opioid crisis, but that the museum will be examining its gift acceptance policies. The Guggenheim, home to the Sackler Center for Arts Education, had no comment. A Harvard spokesman said in an email that Arthur Sackler’s donation in 1982 paid for the construction of the building that originally housed the museum but that his foundation does not fund the museum. ___ Associated Press reporter Verena Dobnik contributed to this report from New York. ___ Follow Alanna Durkin Richer at http://www.twitter.com/aedurkinricher
[A]: Opioid crisis brings unwanted attention to wealthy family.


[Q]: No one was killed in the incident in Mato Grosso state, ANM said in a statement. The dam is registered under the name of an individual wildcat miner rather than in the name of a mining company. Inspections of the dam had not turned up any problems, and it had been declared as stable on Sept. 25, the agency said. Brazil remains on high alert for dam ruptures after a tailings dam at a Vale SA iron ore mine burst in January, killing at least 250 people in the second major disaster of its kind in four years.
[A]: Health tourism costs nearly £300 million on some estimates.


[Q]: Pfizer shares were up nearly 4 percent on positive findings for the oral treatment, called palbociclib, one of the company’s most important experimental drugs that some analysts believe could eventually claim annual sales of more than $5 billion, if approved. The trial tested the pill in post-menopausal patients with locally advanced or newly diagnosed breast cancer that had spread to other parts of the body. “We are delighted with the final data,” Pfizer said in a release, adding the company will discuss the successful data on progression-free survival with the U.S. Food and Drug Administration “to determine next steps” for palbociclib. A secondary goal of the study is to determine whether palbociclib can prolong overall survival. But Pfizer spokeswoman Sally Beatty said the company does not yet have such data, because it takes longer periods to follow patients and gauge survival trends. Although Pfizer is conducting two larger late-stage trials of palbociclib, ISI Group analyst Mark Schoenebaum noted the company has previously said it might discuss with the FDA the potential to seek approval of the medicine based upon mid-stage trial data, if the data warranted. Palbociclib, which blocks enzymes known as cyclin-dependent kinases (CDKs) 4 and 6, was taken in combination with a standard treatment called letrozole among women who were estrogen receptor positive - meaning tumors grow in response to estrogen - and HER2-negative, meaning that the HER2 protein is not causing the cancer. Such patients make up about 60 percent of advanced breast cancer cases. Letrozole is the chemical name of Femara, a Novartis AG drug that belongs to a class of treatments called aromatase inhibitors that block production of estrogen. Pfizer on Monday did not present detailed data from the trial results, saying they would be presented at a scientific meeting in San Diego in April. The success of the trial, called Paloma-1, follows highly favorable interim data that Pfizer unveiled in December 2012. At that point in the study, those taking both palbociclib and letrozole went an average of 26.1 months before tumors worsened. That compared with 7.5 months for those taking letrozole, but not palbociclib. The 18.6-month difference was considered statistically significant. Side effects from palbociclib were similar to those previously reported, Pfizer said on Monday. The earlier interim results had shown that patients taking the drug combination experienced anemia, fatigue and neutropenia - a decline in white blood cells called neutrophils that can put patients at higher risk of infection. Palbociclib was designated a “breakthrough” drug by the FDA last April based on initial data from the trial. The FDA grants “breakthrough” status to drugs that may offer substantial improvement over existing treatments for serious or life-threatening diseases. The status helps to speed up the approval process. Pfizer has started two late-stage trials of the drug - Paloma-2 and Paloma-3 - in patients with advanced breast cancer. Paloma-2 will test the same drug combination, palbociclib and letrozole, as an initial treatment for breast cancer. Paloma-3 will evaluate palbociclib in combination with another hormone therapy, fulvestrant, in women whose cancer has progressed after hormonal therapy. The drug, sold under the brand name Faslodex by AstraZeneca Plc, is called an estrogen receptor antagonist. Companies trying to develop treatments similar to palbociclib include Novartis and Eli Lilly & Co. Breast cancer killed more than 508,000 women worldwide in 2011, according to the World Health Organization. Pfizer shares were up 3.7 percent at $31.53 on Monday morning on the New York Stock Exchange.
[A]:
Pfizer breast cancer drug succeeds in mid-stage trial.