Given a passage classify if the passage has a definite objective/aim/goal or not. Output '1' if the passage has a defininte objective/aim/goal and output '0' if the passage does not have a definite objective/aim/goal.

In recent years, with the introduction of Enhanced Recovery After Surgery (ERAS) or Fast-Track protocols, perioperative care for colonic surgery has changed significantly. This is the experience of a single surgeon within a public hospital in New Zealand.', 'Between October 2005 and July 2007, consecutive patients undergoing segmental colonic resection by the senior author (AGH) were managed within a multimodal structured perioperative care pathway.', 'Thirty-two consecutive patients had elective colonic surgery without a stoma. Two were excluded because of cognitive impairment. The 30 remaining patients had a median age of 68.5 years (range 37-92) and a median daystay of 3 days (range 3-21). There were four (13%) readmissions, including one anastomotic leak.
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Methotrexate (MTX) is the anchor drug in the treatment of patients with rheumatoid arthritis (RA). MTX shows effects on disease activity and mortality. However, it is unclear whether the effect of MTX on mortality depends on its effect on disease activity.', 'In a post-hoc analysis we analysed the data of our cohort established in Ratingen, Germany, and included all patients starting treatment with MTX (n=271) between 1980 and 1987. One year after baseline (BL), response to MTX treatment was assessed using a modified ACR 20 response. Follow-up data of 250 patients were available after 10 and 18 years.', 'After 1 year, there were 66% responders and 20% non-responders; only 14% had discontinued MTX treatment due to side effects or lack of efficacy. Most patients continued MTX treatment irrespective of efficacy. Ten years after BL, 61% of the patients were still treated with MTX. After 18 years, the responder-group showed a standardised mortality ratio of 1.6 compared to 3.2 for the group of non-responders. However, when adjusting for age, gender, response to MTX treatment one year after BL, number of swollen joints and comorbidities after 10 years an independent association of continued MTX treatment with lower mortality was found for the period 10 to 18 years after BL (hazard ratio (HR): 0.63, 95% confidence interval: 0.43-0.92, p=0.015).
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Pathological complete remission (pCR) of estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer is rarely achieved after neoadjuvant chemotherapy (NAC). In addition, the prognostic value of pCR for this breast cancer subtype is limited. We explored whether response evaluation by magnetic resonance imaging (MRI) is associated with recurrence-free survival after NAC in ER-positive/HER2-negative breast cancer.', 'MRI examinations were performed in 272 women with ER-positive/HER2-negative breast cancer before, during and after NAC. MRI interpretation included lesion morphology at baseline, changes in morphology and size, and contrast uptake kinetics. These MRI features, clinical characteristics and final pathology were correlated with recurrence-free survival.', 'The median follow up time was 41 months. There were 35 women with events, including 19 breast-cancer-related deaths. On multivariable analysis, age younger than 50 years (hazard ratio (HR)\u2009=\u20092.55, 95 % confidence interval (CI) 1.3, 5.02, p\u2009=\u20090.007), radiological complete response after NAC (HR\u2009=\u200914.11, CI 1.81, 1818; p\u2009=\u20090.006) and smaller diameters of washout/plateau enhancement at MRI after NAC (HR\u2009=\u20091.02, CI 1.00, 1.04, p\u2009=\u20090.036) were independently associated with best recurrence-free survival. Pathological response was not significant; HR\u2009=\u20092.12, CI 0.86, 4.64, p\u2009=\u20090.096.

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