Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
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Question: Question: Does dNA Methylation of MMP9 be Associated with High Levels of MMP-9 Messenger RNA in Periapical Inflammatory Lesions?
Answer: The present study suggests that the unmethylated status of the MMP9 gene in periapical lesions may explain the observed up-regulation of messenger RNA transcription in these lesions.

Answer: yes


Question: Question: Does novel individual metabolic profile characterize the protein kinase B-alpha ( pkbα-/- ) in vivo model?
Answer: Specific metabolic characterization should be assessed individually. Therefore, our in silico model enables novel insights inaugurating specific primary preventive strategies targeting individual metabolic profiling precisely.

Answer: yes


Question: Question: Do amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease?
Answer: Clinically normal individuals who are APOE ε4+ and have high Aβ showed the highest cognitive decline. These results suggest that Aβ and APOE ε4 are not redundant contributors of decline in aging but rather interact to promote decline during the short follow-up period examined in this study. Longer follow-up periods will be essential to fully elucidate the influence of Alzheimer disease risk factors on cognitive decline in aging.

Answer:
yes