TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Does apelin-13 protect the heart against ischemia-reperfusion injury through the RISK-GSK-3β-mPTP pathway?
Answer: The protective mechanism of apelin-13 might be that inactivation of GSK-3β could inhibit the opening of mPTP by activating PI3K/Akt and ERK1/2 involved in the reperfusion injury salvage kinase (RISK) pathway.

SOLUTION: yes

PROBLEM: Question: Is [ The incidence of postoperative nausea and vomiting effected by routinely applied manual pre-oxygenation during induction of anesthesia ]?
Answer: Since neither routine pre-intubation positive pressure mask ventilation nor the medical qualification of the anesthesilogist affect the incidence of PONV neither variable needs to be taken into account in studies concerning PONV.

SOLUTION: no

PROBLEM: Question: Does high prevalence of goiter in schoolchildren in Isfahan ; zinc deficiency play a role?
Answer: The prevalence of goiter is still high in Isfahan schoolchildren. It seems that zinc status is not involved in the high prevalence of goiter in this region. The role of other possible goitrogens should be investigated in Isfahan.

SOLUTION:
no