TASK DEFINITION: Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.
PROBLEM: Question: Is expression of epigenetic modifiers significantly altered by exposure to secondhand smoke?
Answer: Quantification of the expression of genes encoding DNA methyltransferases (Dnmt1, Dnmt3a, Dnmt3b and Dnmt3l), methyl binding domain proteins (Mecp2, Mbd2 and Mbd3) and histone deacetylases (Hdac1 and Hdac2) by quantitative reverse-transcription polymerase chain reaction analysis showed modest but not statistically significant differences in the relative transcription of these key epigenetic regulators between SHS-exposed mice and age-matched controls. The non-significant changes in the expression of main epigenetic modifiers in SHS-exposed mice imply that SHS may predominantly induce genotoxic effects, particularly at non-tumorigenic doses, whereas epigenetic effects may only be secondary and manifest en route to tumor formation.

SOLUTION: no

PROBLEM: Question: Does single copy of variant CYP2A6 alleles confer susceptibility to liver dysfunction in patients treated with coumarin?
Answer: No evidence was obtained that the studied polymorphism in CYP2A6 is a determinant of the coumarin-associated liver dysfunction.

SOLUTION: no

PROBLEM: Question: Do xenon and nitrous oxide depress cardiac function in an isolated rat heart model?
Answer: Our data suggest that cardiac contractility was decreased by the effects of reduced O2 delivery, but both Xe and N2O did not cause further cardiac depressant effects compared to N2 in this experimental model.

SOLUTION:
no