Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: Phosphorylation of cytoplasmic polyadenylation element binding protein (CPEB) regulates protein synthesis in hippocampal dendrites. CPEB binds the 3' untranslated region (UTR) of cytoplasmic mRNAs and, when phosphorylated, initiates mRNA polyadenylation and translation. We report that, of the protein kinases activated in the hippocampus during synaptic plasticity, calcium/calmodulin-dependent protein kinase II (CaMKII) robustly phosphorylated the regulatory site (threonine 171) in CPEB in vitro. In postsynaptic density fractions or hippocampal neurons, CPEB phosphorylation increased when CaMKII was activated. These increases in CPEB phosphorylation were attenuated by a specific peptide inhibitor of CaMKII and by the general CaM-kinase inhibitor KN-93. Inhibitors of protein phosphatase 1 increased basal CPEB phosphorylation in neurons; this was also attenuated by a CaM-kinase inhibitor. To determine whether CaM-kinase activity regulates CPEB-dependent mRNA translation, hippocampal neurons were transfected with luciferase fused to a 3' UTR containing CPE-binding elements. Depolarization of neurons stimulated synthesis of luciferase; this was abrogated by inhibitors of protein synthesis, mRNA polyadenylation, and CaMKII. These results demonstrate that CPEB phosphorylation and translation are regulated by CaMKII activity and provide a possible mechanism for how dendritic protein synthesis in the hippocampus may be stimulated during synaptic plasticity.

A: Which kinase is inhibited by the small molecule KN-93?
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Q: Gregory A. Feest (born 1956) is a United States Air Force Air Force major general who is currently serving as the Chief of Safety of the United States Air Force, Headquarters U.S. Air Force, Washington, D.C., and Commander, Air Force Safety Center, Kirtland Air Force Base, New Mexico.

A: What military branch did Gregory A. Feest belong to?
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Q: Brepols was once one of the largest printing companies of the world and one of the main employers in Turnhout (Belgium).

A:
In what city or state did the formation of Brepols occur?
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