In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.
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Question: Question: Before a 49-year-old man, asymptomatic, with a family history of a father who died of prostate cancer, a PSA (Specific Prostate Antigen) of 5.9 ng / ml was identified in a routine company control, with a PSA ratio free / Total PSA of 11% and that in a digital rectal examination there is an increase in consistency in the right prostatic lobe, what is the following clinical indication? 
 Options:  <1> Ask the patient to perform a transrectal ultrasound and prostate biopsy. <2> Perform a abdominopelvic CT scan. <3> Start treatment with 5 alpha reductase inhibitors to halve PSA levels. <4> Start combined treatment of LHRH analogues and antiandrogens. <5> Perform a bone scan.

Answer: 1


Question: Question: The hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C generates the following second messengers: 
 Options:  <1> Inositol 1,4,5-trisphosphate and triacylglycerol. <2> Inositol 1,4, 5-trisphosphate and glycerol. <3> Inositol 1,4, 5-trisphosphate and diacylglycerol. <4> Inositol 4,5-bisphosphate and diacylglycerol. <5> Inositol 4,5-bisphosphate and glycerol.

Answer: 3


Question: Question: Which statement regarding the substitution treatment with L-thyroxine in a patient with hypothyroidism is correct? 
 Options:  <1> Thyroid function will be determined 48 hours after its initiation to assess efficacy. <2> In elderly patients and in order to improve symptomatology quickly, treatment with L-T4 is started at a dose of 150-200 micrograms per day. <3> In pregnancy, thyroid hormone requirements usually increase by about 50 micrograms per day, over the previous dose. <4> The medication should be taken in the middle of meals. <5> It is advisable to administer a gastric protector simultaneously to avoid gastritis.

Answer:
3