Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: CC's (pronounced cee-cees) is a brand of flavoured tortilla chips produced since the early 1980s, originally by The Smith's Snackfood Company, and currently by Snack Brands Australia.

Answer: The country for CC's was what?


Question: Imatinib mesylate is a new drug that can inhibit the tyrosine kinase activity of Bcr-Abl, the receptors for platelet-derived growth factor receptor(PDGF) and stem cell factor, or c-kit. Chronic myeloid leukemia (CML) is distinguished by the presence of a reciprocal translocation between chromosomes 9 and 22 that results in a shortened chromosome 22, termed the Philadelphia(Ph) chromosome. As a result of the translocation, a fusion gene called the Bcr-Abl gene is created from two normal cellular genes, encoding a chimeric Bcr-Abl protein with a deregulated tyrosine kinase activity. The expression of Bcr-Abl tyrosine kinase has been shown to be necessary and sufficient for the transformed phenotype of CML cells. Imatinib can block the kinase activity of Bcr-Abl, thus inhibiting the proliferation of Ph-positive progenitors, and has shown activity against all phases of CML, though responses are most substantial and durable in patients in the chronic phase. An international phase III study which compared the efficacy of imatinib with that of interferon alpha combined with low-dose cytarabine in newly diagnosed chronic-phase CML showed the rate of major cytogenetic response at 24 months was 90%, including 82% of complete cytogenetic response. These results indicated that imatinib was superior to interferon-containing treatment as a first-line therapy. More than 10,000 patients worldwide, including those in Japan, have been treated with imatinib in clinical trials, and a lot of information has been accumulated on the use of this drug. The aim of this article is to review the use of this drug and the practical management of patients with chronic myeloid leukemia.

Answer: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Question: Alfred Wegener, born in 1880, was a meteorologist and explorer. In 1911, Wegener found a scientific paper that listed identical plant and animal fossils on opposite sides of the Atlantic Ocean. Intrigued, he then searched for and found other cases of identical fossils on opposite sides of oceans. The explanation put out by the scientists of the day was that land bridges had once stretched between these continents. Instead, Wegener pondered the way Africa and South America appeared to fit together like puzzle pieces. Other scientists had suggested that Africa and South America had once been joined, but Wegener was the ideas most dogged supporter. Wegener amassed a tremendous amount of evidence to support his hypothesis that the continents had once been joined. Imagine that youre Wegeners colleague. What sort of evidence would you look for to see if the continents had actually been joined and had moved apart? Here is the main evidence that Wegener and his supporters collected for the continental drift hypothesis: The continents appear to fit together. Ancient fossils of the same species of extinct plants and animals are found in rocks of the same age but are on continents that are now widely separated (Figure 1.1). Wegener proposed that the organisms had lived side by side, but that the lands had moved apart after they were dead and fossilized. His critics suggested that the organisms moved over long-gone land bridges, but Wegener thought that the organisms could not have been able to travel across the oceans. Fossils of the seed fern Glossopteris were too heavy to be carried so far by wind. Mesosaurus was a swimming reptile, but could only swim in fresh water. Cynognathus and Lystrosaurus were land reptiles and were unable to swim. Wegener used fossil evidence to support his continental drift hypothesis. The fos- sils of these organisms are found on lands that are now far apart. Identical rocks, of the same type and age, are found on both sides of the Atlantic Ocean. Wegener said the rocks had formed side by side and that the land had since moved apart. Mountain ranges with the same rock types, structures, and ages are now on opposite sides of the Atlantic Ocean. The Appalachians of the eastern United States and Canada, for example, are just like mountain ranges in eastern Greenland, Ireland, Great Britain, and Norway (Figure 1.2). Wegener concluded that they formed as a single mountain range that was separated as the continents drifted. Grooves and rock deposits left by ancient glaciers are found today on different continents very close to the Equator. This would indicate that the glaciers either formed in the middle of the ocean and/or covered most of the Earth. Today, glaciers only form on land and nearer the poles. Wegener thought that the glaciers were centered over the southern land mass close to the South Pole and the continents moved to their present positions later on. The similarities between the Appalachian and the eastern Greenland mountain ranges are evidences for the continental drift hypothesis. Coral reefs and coal-forming swamps are found in tropical and subtropical environments, but ancient coal seams and coral reefs are found in locations where it is much too cold today. Wegener suggested that these creatures were alive in warm climate zones and that the fossils and coal later drifted to new locations on the continents. Wegener thought that mountains formed as continents ran into each other. This got around the problem of the leading hypothesis of the day, which was that Earth had been a molten ball that bulked up in spots as it cooled (the problem with this idea was that the mountains should all be the same age and they were known not to be). Click image to the left or use the URL below. URL:

Answer:
the coast of south america fits closely to this continent like a puzzle piece.