In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Example Input: Paragraph: Severe inflammation may lead to multiple organs dysfunction syndrome, which has a high mortality. MicroRNA is found participated in this process. In this study we developed a lipopolysaccharide-induced inflammation cell model on macrophages and a lipopolysaccharide-induced inflammation mouse model. It was found that during inflammation, microRNA-9 was increased, accompanied with the up-regulation of pro-inflammatory cytokines and anti-inflammatory cytokines. Down-regulation of microRNA-9 inhibited the up-regulation of inflammatory cytokines, promoted the up-regulation of anti-inflammatory cytokines and induced the remission of organ damage, showing a protective effect in inflammation. Bioinformatics analysis combined with luciferase reporter assay showed that SIRT1 was the target gene of microRNA-9. Transfection of microRNA-9 inhibitor could increase the level of SIRT1 and decrease the activation of NF-κB pathway in macrophages. Myeloid specific sirt1 knockout mice were included and we found that lack of SIRT1 in mice macrophages led to aggravated inflammation, cell apoptosis and organ injury, and eliminated the protective property of microRNA-9 inhibitor. In conclusion, we demonstrated that inhibition of microRNA-9 could alleviate inflammation through the up-regulation of SIRT1 and then suppressed the activation of NF-κB pathway. This is a meaningful explore about the specific mechanism of microRNA-9 in inflammation. 
 Title: Inhibition of SIRT1 by microRNA-9, the key point in process of LPS-induced severe inflammation
Example Output: False

Example Input: Paragraph: Background: Newcastle Disease virus (NDV) causes severe and economically significant disease in almost all birds. However, factors that affect NDV replication in host cells are poorly understood. NDV generates long double-stranded RNA (dsRNA) molecules during transcription of single-stranded genomic RNA. Protein kinase R (PKR) is activated by dsRNA. The aim of this study was to elucidate the role of PKR in NDV infection. Results: NDV infection led to the activation of dsRNA-dependent PKR and phosphorylation of its substrate, translation initiation factor eIF2α, in a dose-dependent manner by either the lentogenic strain LaSota or a velogenic strain Herts/33. PKR activation coincided with the accumulation of dsRNA induced by NDV infection. PKR knockdown remarkably decreased eIF2α phosphorylation as well as IFN-β mRNA levels, leading to the augmentation of extracellular virus titer. Furthermore, siRNA knockdown or phosphorylation of eIF2α or okadaic acid treatment significantly impaired NDV replication, indicating the critical role of the PKR/eIF2α signaling cascade in NDV infection. Conclusion: PKR is activated by dsRNA generated by NDV infection and inhibits NDV replication by eIF2α phosphorylation. This study provides insight into NDV-host interactions for the development of candidate antiviral strategies. 
 Title: Activation of the PKR/eIF2α signaling cascade inhibits replication of Newcastle disease virus
Example Output: False

Example Input: Paragraph: It is an exciting time in the field of microbiology because of the expansion of rapid diagnostic tests. Pathogen testing previously was performed by traditional laboratory methods such as bacterial, fungal, and viral culture or ova and parasite (O&P) examination. Testing could have a slow time to results; some testing lacked sensitivity, and most testing was centralized in the laboratory. Newer advances in pathogen detection assays are now providing rapid results and have greater sensitivity and specificity, and many assays are moving out of the centralized laboratory and to the patient as pointof-care tests. In this review, the authors chose to highlight the currently available US Food and Drug Administration (FDA)-cleared molecular assays for various infectious syndromes relevant to the pediatric population. Although outcome studies in this area are sparse, rapid results may result in decreased time to optimal antimicrobial treatment and improved patient outcomes. Disclosure Statement: E. McElvania is a consultant for Luminex Corporation. M.D. Gonzalez has no disclosures. KEYWORDS Rapid diagnostic assays Group A streptococcus Influenza RSV Syndromic multiplex panels Gastrointestinal panel Respiratory panel Meningitis encephalitis panel Compared with traditional rapid antigen testing, new diagnostics assays for Group A Streptococcus, influenza, and respiratory syncytial virus combine rapid turnaround time with high sensitivity and specificity. There has been a surge in the availability of multiplex syndromic panels that test for a broad range of pathogens associated with a single clinical presentation. Molecular infectious disease testing that was previously performed in microbiology laboratories is now being developed in easy-to-use platforms, which are available at point of care. 
 Title: New Developments in Rapid Diagnostic Testing for Children
Example Output:
False