In medical studies, the efficacy of medical treatments (called interventions) is evaluated within a group of study participants. You will be given a sentence of a study report in which your task is to list the phrases that describe the intervention(s) of the study. You should list the phrase in the same order that they appear in the text, separated by commas. If no information about the interventions is mentioned, just answer with "not found". Interventions are: a specific drug, surgery, talking therapy, a lifestyle modification, control or placebo treatment. Do not include details, dosages, frequency and duration, intervention mentions that are not in an informative span of text.

MLMs indicated a slight increase in depressive symptoms over time in the sample as a whole .
not found

A new immunomodulating agent , bestatin ( INN : Ubenimex has low toxicity even after long-term oral administration and has significant modifications in immunological response .
bestatin

However , no study to date has examined whether or not they understand conceptual metaphors ( i.e . mappings between conceptual structures ) , which could be the building blocks of metaphoric thinking and understanding .

not found