TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: The Volvo B12M is an underfloor-engined bus/coach chassis introduced by Volvo Buses in 2001 as a replacement for the Volvo B10M.

SOLUTION: What year was Volvo B12M commissioned?

PROBLEM: The State of Rhode Island has become a popular family seaside destination. In addition to beach activities and water sports, kids can participate in supervised activities at cultural centres and tourist attractions around the state. The Kayak Centre of Rhode Island The Kayak Centre of Rhode Island offers Oceanplay to kids, a program for children between 9 and 14 years old. The course teaches basic kayak skills and safety protocol on the waters around historic Wickford Village. The all-day program includes games and skill-building activities at all skill levels. The package includes equipment, instructions and lunch. The Courthouse Centre for the Arts The Courthouse Centre for the Arts offers summer camp educational workshops and fine arts programs to kids who want to learn about theatre, dance, classical music and different art mediums. Kids and families can also enjoy concerts, film screenings and theatre performances. The Providence Children's Museum The Providence Children's Museum hosts daily drop-in programs for kids between 5 and 11 years of age and museum adventure classes. Kids can learn how water moves in the Water Ways exhibit, listen to music and learn about plants in the Children's Garden exhibit. The RISD Museum The RISD Museum hosts family workshops and activities for kids between 5 and 12 years of age on alternating Sunday afternoons. Kids can learn different types of art techniques and work with different mediums in a supervised setting. Families taking a self-guided tour of the museum can see exhibits.

SOLUTION: What will a child interested in plants probably visit?

PROBLEM: Empagliflozin is a selective sodium glucose cotransporter 2 (SGLT2) inhibitor that inhibits renal glucose reabsorption and is being investigated for the treatment of type 2 diabetes mellitus (T2DM). In this open-label study, the effect of renal impairment on the pharmacokinetics, pharmacodynamics and safety of a 50mg dose of empagliflozin was investigated in 40 subjects, grouped according to estimated glomerular filtration rate (eGFR). Maximum empagliflozin plasma concentrations were similar in subjects with normal renal function and renal impairment. Area under the empagliflozin concentration-time curve (AUC0 - ) values increased by approximately 18, 20, 66 and 48% in subjects with mild, moderate, severe renal impairment and renal failure/end stage renal disease (ESRD), respectively, in comparison to healthy subjects. This was attributed to decreased renal clearance (CLR ). Urinary glucose excretion (UGE) decreased with increasing renal impairment and correlated with decreased eGFR and CLR . Empagliflozin was well tolerated, with no increase in adverse events associated with renal impairment. Renal insufficiency resulted in decreased CLR of empagliflozin, moderately increased systemic exposure and decreased UGE. A single 50mg dose of empagliflozin was well tolerated in subjects with normal renal function and any degree of renal impairment. The pharmacokinetic results of this study indicate that no dose adjustment of empagliflozin is required in patients with renal impairment.

SOLUTION:
Which protein does empagliflozin inhibit?