In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Input: Consider Input: Question: Before a 49-year-old man, asymptomatic, with a family history of a father who died of prostate cancer, a PSA (Specific Prostate Antigen) of 5.9 ng / ml was identified in a routine company control, with a PSA ratio free / Total PSA of 11% and that in a digital rectal examination there is an increase in consistency in the right prostatic lobe, what is the following clinical indication? 
 Options:  <1> Ask the patient to perform a transrectal ultrasound and prostate biopsy. <2> Perform a abdominopelvic CT scan. <3> Start treatment with 5 alpha reductase inhibitors to halve PSA levels. <4> Start combined treatment of LHRH analogues and antiandrogens. <5> Perform a bone scan.

Output: 1


Input: Consider Input: Question: Epidemiology allows early detection of changes in the incidence of a certain disease in the population. For this, the most correct thing is to use: 
 Options:  <1> The etiological investigation. <2> The description of the natural history of the disease. <3> Epidemiological surveillance. <4> The evaluation of the functioning of the services. <5> None of the previous answers is correct.

Output: 3


Input: Consider Input: Question: Type II restriction endonucleases cleave the DNA molecule: 
 Options:  <1> Within its recognition sequence. <2> Randomly <3> Out of the recognition sequence. <4> At the 5 'end. <5> At the 3 'end.


Output: 1