Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: Conker's Bad Fur Day is an action-platform video game developed by Rare for the Nintendo 64 video game console.
[A]: Which company developed the videogame Conker's Bad Fur Day?


[Q]: In melanoma, transition to the vertical growth phase is the critical step in conversion to a deadly malignant disease. Here, we offer the first evidence that an antioxidant enzyme has a key role in this transition. We found that the antioxidant enzyme peroxiredoxin-2 (Prx2) inversely correlated with the metastatic capacity of human melanoma cells. Silencing Prx2 expression stimulated proliferation and migration, whereas ectopic expression of Prx2 produced the opposite effect. Mechanistic investigations indicated that Prx2 negatively regulated Src/ERK activation status, which in turn fortified adherens junctions function by increasing E-cadherin expression and phospho-Y654-dependent retention of -catenin in the plasma membrane. In murine melanoma cells, Prx2 silencing enhanced lung metastasis in vivo. Interestingly, the natural compound gliotoxin, which is known to exert a Prx-like activity, inhibited proliferation and migration as well as lung metastasis of Prx2-deficient melanoma cells. Overall, our findings reveal that Prx2 is a key regulator of invasion and metastasis in melanoma, and also suggest a pharmacologic strategy to effectively decrease deadly malignant forms of this disease.
[A]: What type of enzyme is peroxiredoxin 2 (PRDX2)?


[Q]: Many disorders of the reproductive system are not sexually transmitted infections. They are not caused by pathogens, so they dont spread from person to person. They develop for other reasons. The disorders are different between males and females. In both genders, the disorders could cause a little discomfort, or they could cause death. Most common disorders of the male reproductive system involve the testes. For example, injuries to the testes are very common. In teenagers, injuries to the testes most often occur while playing sports. An injury such as a strike or kick to the testes can be very painful. It may also cause bruising and swelling. Such injuries do not usually last very long. Another disorder of the testes is cancer. Cancer of the testes is most common in males aged 15 to 35. It occurs when cells in the testes grow out of control. The cells form a lump called a tumor. If found early, cancer of the testes usually can be easily cured with surgery. Disorders of the female reproductive system may affect the vagina, uterus, or ovaries. They may also affect the breasts. One of the most common disorders is vaginitis. This is redness and itching of the vagina. It may be due to irritation by soap or bubble bath. Another possible cause of vaginitis is a yeast infection. Yeast normally grow in the vagina. A yeast infection happens when the yeast multiply too fast and cause symptoms. A yeast infection can be treated with medication. Bubble baths may be fun, but for women and girls they can cause irritation to the vagina. A common disorder of the ovaries is an ovarian cyst. A cyst is a sac filled with fluid or other material. An ovarian cyst is usually harmless, but it may cause pain. Most cysts slowly disappear and do not need treatment. Very large or painful cysts can be removed with surgery. Many teen girls have painful menstrual periods. They typically have cramping in the lower abdomen. Generally, this is nothing to worry about. Taking a warm bath or using a heating pad often helps. Exercise can help as well. A pain reliever like ibuprofen may also work. If the pain is severe, a doctor can prescribe stronger medicine to relieve the pain. The most common type of cancer in females is breast cancer. The cancer causes the cells of the breast to grow out of control and form a tumor. Breast cancer is rare in teens. It becomes more common as women get older. If breast cancer is found early, it usually can be cured with surgery.
[A]:
cancer of the testes is most common in males aged