Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: Chronic myeloid leukemia (CML) is a progressive and often fatal myeloproliferative neoplasm. The hallmark of CML is an acquired chromosomal translocation known as the Philadelphia chromosome (Ph), which results in the synthesis of the breakpoint cluster region-Abelson murine leukemia (BCR-ABL) fusion oncoprotein, a constitutively active tyrosine kinase. The introduction of imatinib, a tyrosine kinase inhibitor (TKI) that is specific for BCR-ABL, was a major breakthrough in CML therapy. Although most patients respond to first-line imatinib therapy, some experience loss of response (resistance) or require treatment discontinuation because of toxicity (intolerance). For patients with CML, failure on standard-dose imatinib therapy (400 mg daily), imatinib dose escalation (600-800 mg daily) is a second-line option. However, high-dose imatinib is not an appropriate approach for patients who experience drug toxicity, and there remain questions over the durability of responses achieved with this strategy. Alternative second-line options include the TKIs dasatinib and nilotinib. A substantial amount of long-term data for these agents is available. Although both are potent and specific BCR-ABL TKIs, dasatinib and nilotinib exhibit unique pharmacologic profiles and response patterns relative to different patient characteristics, such as disease stage and BCR-ABL mutation status. To optimize therapeutic benefit, clinicians should select treatment based on each patient's historic response, adverse-event tolerance, and risk factors.

A: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?
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Q: You're in your office when you learn there's someone with a gun wandering outside. You can hear gunshots and screams. What do you do? That's the challenge for users of a new virtual reality program called SurviVR, designed to train employees how to deal with an active shooter situation in the workplace. The program works with HTC Vive, the virtual reality headset released earlier this year. An active shooter situation is when an armed person or people actively shoot in a small, populated area with the intention to kill. There were 20 such situations in the United States last year and 20 the year before, according to FBI statistics, resulting in a total of 231 deaths. This year saw the deadliest active shooter situation in US history , with 49 people killed in a nightclub in Orlando. In the training situation, users have four choices. They can lock themselves in the office. They can hide, perhaps in the office closet. They can run for an exit. Or they can use something in the office--a computer or a cup a pair of scissors-as a weapon to fight the shooter. This is an improvement on standard active shooter training. Gallo says, which typically teachers people to lock themselves in place and hide. The "lock down" method is often ineffective, he says, and has resulted in many deaths in recent years. In the training's basic level, no one gets killed. But as the trainings become more advanced, players who make a wrong choice be shot. There's no blood; the screen simply turns black slowly. If this sounds terrifying, that's the point, says Gallo. There are plenty of training programs to teach employees how to deal with workplace violence, sometimes involving role play with toy guns. But these trainings are basically games. Gallo says, with employees relaxed and even enjoying themselves. To teach people what they really need to know for an active shooter situation, they need to be scared. "SurviVR will take the fear and turn it into confidence." Gallo says.

A: What does Gallo think of the training programs involving role play with toy guns?
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Q: The Green Revolution has brought enormous impacts to the planet. Natural landscapes have been altered to create farmland and cities. Already, half of the ice-free lands have been converted to human uses. Estimates are that by 2030, that number will be more than 70%. Forests and other landscapes have been cleared for farming or urban areas. Rivers have been dammed and the water is transported by canals for irrigation and domestic uses. Ecologically sensitive areas have been altered: wetlands are now drained and coastlines are developed. Modern agricultural practices produce a lot of pollution (Figure 1.1). Some pesticides are toxic. Dead zones grow as fertilizers drain off farmland and introduce nutrients into lakes and coastal areas. Farm machines and vehicles used to transport crops produce air pollutants. Pollutants enter the air, water, or are spilled onto the land. Moreover, many types of pollution easily move between air, water, and land. As a result, no location or organism not even polar bears in the remote Arctic is free from pollution. The increased numbers of people have other impacts on the planet. Humans do not just need food. They also need clean water, secure shelter, and a safe place for their wastes. These needs are met to different degrees in different nations and among different socioeconomic classes of people. For example, about 1.2 billion of the worlds people do not have enough clean water for drinking and washing each day (Figure 1.2). The addition of more people has not just resulted in more poor people. A large percentage of people expect much more than to have their basic needs met. For about one-quarter of people there is an abundance of food, plenty of water, and a secure home. Comfortable temperatures are made possible by heating and cooling systems, rapid trans- portation is available by motor vehicles or a well-developed public transportation system, instant communication takes place by phones and email, and many other luxuries are available that were not even dreamed of only a few The percentage of people in the world that live in abject poverty is decreasing some- what globally, but increasing in some re- gions, such as Sub-Saharan Africa. decades ago. All of these require resources in order to be produced, and fossil fuels in order to be powered (Figure Many people refer to the abundance of luxury items in these peoples lives as over-consumption. People in developed nations use 32 times more resources than people in the developing countries of the world. Click image to the left or use the URL below. URL: Click image to the left or use the URL below. URL:

A:
which of these regions is experiencing an increase in abject poverty?
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