Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[Q]: Bone, as well as the lung and liver, is among the sites of predilection for cancer metastasis. The bone stores large amounts of growth factors such as insulin-like growth factors and transforming growth factor-b, and provides fertile soil for metastatic cancer cells by continuously releasing these bone-stored growth factors, which are a consequence of osteoclastic bone resorption. Metastatic cancer cells in turn produce osteoclast-stimulating cytokines such as parathyroid hormone-related protein( PTH-rP), prostaglandin E2.(PGE2), and various interleukins(ILs). These cancer-produced osteoclast-stimulating cytokines bind to their cognitive receptors and promote the expression of ligands for the receptor activators of nuclear factor kB (RANKL)in osteoblasts. RANKL then binds to its receptor RANK, expressed in pre-osteoclasts, stimulates mature osteoclast formation, and subsequently, osteoclastic bone resorption. This vicious cycle between metastatic cancer cells and osteoclasts is critical to the development and progression of bone metastases. In addition, it is likely that metastatic cancer cells are influenced by bone environments(or niche)and acquire additional capacities such as an epithelial-mesenchymal transition(EMT), allowing them to be resistant to chemotherapy or apoptosis, to survive in a dormant state, or to aggressively spread to distant organs including lung and liver. Thus, the bone can serve as transit port. Disrupting this cycle by inhibiting osteoclastic bone resorption, antagonizing bone-derived growth factors, and neutralizing RANKL or PTH-rP, should be a promising therapeutic intervention for bone metastases. Bisphosphonates(BP)are specific inhibitors of osteoclasts, and have been shown to significantly reduce skeletal-related events(SRE)associated with bone metastasis. Denosumab is a neutralizing monoclonal antibody to RANKL and has recently been found to inhibit SRE more effectively than BP. Further understanding of the crosstalk communication between metastatic cancer cells and bone at the molecular level should lead us to design novel, more effective and specific treatments for cancer patients with bone metastases.
[A]: To the ligand of which receptors does Denosumab (Prolia) bind?


[Q]: Alexey Suetin was married to Woman Grandmaster Kira Zvorykina and together they had a son Aleksandr, born 1951.
[A]: What is Alexey Suetin's spouse's name?


[Q]: "Since the dawn of what became a legend, the most unimaginable is about to occur . This summer, experience the absolute conquest of all mankind. Beginning with one search. For the one and only. The chosen one. Descended from the heavens above. Welcome to Dragon Wars."A STORY THAT HAS BEEN LOST TO MANKIND...CONCEPT:"Dragons are mythical, legendary creatures found in cultures throughout the world. However, the Imoogi possesses extraordinary powers that allow it to transform itself into a dynamic, powerful and sometimes demonic animal.In mythology, the Dragon is characterized as a divine governor of water and rain. People held sacrificial rites to the God of King Dragon to pray for rain or protection from deadly storms . These sacrificial rites also included prayers to the Imoogi because it had the ability to cause droughts by filling the skies with fire. There are still actual remnants around the cult-like shrines and prayer altars used to worship the Imoogi thousands of years ago.Yeouijoo, a symbol for Dragon, refers to a magical pearl possessing the power to grant any wish. Legend has it that an Imoogi can transform itself into a Dragon if it acquires the Yeouijoo .Every five hundred years, the Imoogi have the ability to become Dragons and, thereby, conquer the world by obtaining the magical Yeouijoo.The Yeouijoo is currently hidden in a young's girl's body. The culmination of the Imoogi's perseverance and determination promises to bring dramatic, devastating and inconceivable consequences .By applying the legend of Imoogi to modern times, D-War is a film that invites us into a new and exceptional world full of suspense, thrill and fantasy !SYNOPSIS:In a small Korean village, five hundred years ago, a girl named Narin was born carrying the coveted Yeouijoo inside her. The Heavens sent the protector Bochun and his protege Haram, to ensure that when it came time, Narin was peacefully sacrificed to the pre-determined Good Imoogi. Bochun vigorously trained Haram as a knight, to be prepared for the eventual day when Narin would be delivered to the Good Imoogi. The day the Dark Imoogi, Buraki, and his army destroyed Narin's village looking for the Yeouijoo, Bochun instructed Haram to take her to the Good Imoogi.The young girl and her knight would then fulfill the giant's serpent's destiny by giving it the power to save the world and become a heavenly dragon. By this time, after spending several years together, Haram and Narin had fallen in love. Unable to sacrifice their love to the benevolent Imoogi, they jumped to their deaths together in each other's arms. The Good Imoogi's destiny was unfulfilled and he would have to wait another five hundred years until the next Yeouijoo appears.It is now five hundred years later in present day Los Angeles and the quest for the Imoogi is reborn. Haram and Narin have been reincarnated as Ethan Kendrick and Sarah Daniels whose bond of love remains unsevered. Ethan is an investigative reporter for the local news. He is closely following a series of unexplainable disasters occurring in the area. When a young woman named Sarah is linked to those occurrences, Ethan remembers that an ancient man he met many years before had predicted all of these events . Ethan finds Sarah and helps her escape the wrath of Buraki and his army. Aware that Sarah must sacrifice herself in order to save the city from the Buraki and ensure that the Good Imoogi becomes the Dragon, Ethan tries to convince Sarah that there is another way to battle the Imoogies. Meanwhile, the FBI agent on the case, Frank Campbell, has uncovered the Imoogies' intentions through his own investigations. Campbell is ready to sacrifice Sarah to the demonic animals to save Los Angeles. In the face of chaos and destruction, Ethan and Sarah must decide their own fate - whether to defy the will of heaven once again and let the city be destroyed or deliver Sarah to the Good Imoogi. "-----end( obtained from Younggu-Art by media liaison, Irene Nakano , in Seoul , Korea / e-mail: soongshil@gmail.com )
[A]:
Who attempts to save Sarah from Buraki?