In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Question: A primary standard solution in a titration should not: 
 Options:  <1> Be prepared from a high purity reagent. <2> Have an exactly known concentration. <3> Keep your composition over time. <4> React instantly. <5> Give rise to secondary reactions.
5

Question: A healthy couple has an 8-year-old daughter with hepatosplenomegaly. The laboratory of biochemical genetics has detected in it a deficiency of the acid beta-glucosidase enzyme (glucocerebrosidase) and molecularly presents the mutation N370S in homozygosis. Which diagnosis is correct? 
 Options:  <1> Fabry disease (Xq22.1). <2> Huntington's disease (4p16.3). <3> Autosomal dominant cerebellar ataxia SCA1 (6p22.3). <4> Adrenoleukodystrophy (Xq28). <5> Gaucher disease (1q22).
5

Question: Mitochondrial oxidative phosphorylation is regulated by: 
 Options:  <1> Mitochondrial steroid hormones. <2> Apoptosis <3> Thermogenin <4> The cytochrome c. <5> The cellular energy charge.

5