In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Example Input: Question: The main indication for using 4 drugs in the initial treatment of tuberculosis is: 
 Options:  <1> Affectation of the central nervous system. <2> High prevalence of primary resistance to isoniazid. <3> Cavitated and extensive pulmonary tuberculosis with large bacillary load. <4> Disseminated tuberculosis associated with HIV infection. <5> Extrapulmonary tuberculosis in immunodepressed patients of any origin.
Example Output: 2

Example Input: Question: With regard to pyrogens and biotechnological medicines, it is possible to say: 
 Options:  <1> They have no tendency to aggregate or form large units with high molecular weight. <2> Ion exchange chromatography procedures (using their positive charge) can reduce endotoxin levels. <3> Ion exchange chromatography procedures (using their negative charge) can reduce endotoxin levels. <4> Ion exchange chromatography procedures (regardless of their charge) can reduce endotoxin levels. <5> They are unstable under standard autoclaving conditions.
Example Output: 3

Example Input: Question: In neurons once an action potential has started, a second action potential can not be triggered for a short period of time, regardless of the intensity of the stimulus applied. This period of time is known as: 
 Options:  <1> Synaptic delay. <2> Threshold depolarizing period. <3> Absolute refractory period. <4> Relative refractory period. <5> Spatial sumary.
Example Output:
3