Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: Einsteinium was discovered as a component of the debris of the first hydrogen bomb explosion in 1952, and named after Albert Einstein.

Output: When was Einsteinium first discovered?


Input: Consider Input: Ataxin-3 (AT3) is the protein that triggers the inherited neurodegenerative disorder spinocerebellar ataxia type 3 when its polyglutamine (polyQ) stretch close to the C-terminus exceeds a critical length. AT3 consists of the N-terminal globular Josephin domain (JD) and the C-terminal disordered one. It cleaves isopeptide bonds between ubiquitin monomers, an event involved in protein quality control mechanisms. AT3 has been implicated in the pathway that sorts aggregated protein to aggresomes via microtubules, in which dynein and histone deacetylase 6 (HDAC6) also seem to be involved. By taking advantage of small angle X-ray scattering (SAXS) and surface plasmon resonance (SPR), we have investigated the interaction of AT3 with tubulin and HDAC6. Based on SAXS results, the AT3 oligomer, consisting of 6-7 subunits, tightly binds to the tubulin hexameric oligomer in a "parallel" fashion. By SPR analysis we have demonstrated that AT3 binds to tubulin dimer with a 50nM affinity. Binding fits with a Langmuir 1:1 model and involves a single binding interface. Nevertheless, the interaction surface consists of three distinct, discontinuous tubulin-binding regions (TBR), one located in the JD, and the two others in the disordered domain, upstream and downstream of the polyQ stretch. In the absence of any of the three TBRs, the affinity is drastically reduced. By SPR we have also provided the first evidence of direct binding of AT3 to HDAC6, with affinity in the range 0.1-1M. These results shed light on the interactions among the components of the transport machinery that sorts aggregate protein to the aggresome, and pave the way to in vivo studies aimed at further clarifying their roles.

Output: Which is the protein implicated in Spinocerebellar ataxia type 3?


Input: Consider Input: England has a longstanding problem with youngsters dropping out of training. Almost half of 17-year-olds in some parts of England have dropped out of fulltime education or training. The statistics show 49% in Thurrock and 44% in Salford have dropped out of school or job training. Across England,31%of 17-year-olds are not in education or training. The figures also reveal deep regional divides,with wealthier areas such as Richmon and Harrow recording18% of 17-year-olds out of official education. The statistics confirm England's poor international standing for staying-on rates in education. The Organization for Economic Cooperation and Development considers England's drop-out rates as among the worst among the industrialised countries. Regionally,the statistics show Yorkshire and the Humber have the highest rate of 17-year-olds not in full-time education or work-based training at 35%. Outer London has the highest staying-on rate,with l3%of 17-year-olds having dropped out of official learning. In the east of England this figure stands at 31%and at 29%in the South West. Edward Davey,Liberal Democrat Shadow Education Secretary,said the government "should be ashamed"that so many youngsters were dropping out of school. A spokesman for the Department for Education and Skills said the government had carried out a series of reforms,with aPS2.5 billion rise in funding for further education.


Output: Which part of England has the lowest rate of 17-year-olds dropping out of education?