In this task, you are given a context, a subject, a relation, and many options. Based on the context, from the options select the object entity that has the given relation with the subject. Answer with text (not indexes).

Context: Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a category of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). Chemotherapy is one of the major categories of medical oncology (the medical discipline specifically devoted to pharmacotherapy for cancer)., A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist involving extraction of sample cells or tissues for examination to determine the presence or extent of a disease. The tissue is generally examined under a microscope by a pathologist, and can also be analyzed chemically. When an entire lump or suspicious area is removed, the procedure is called an excisional biopsy. When only a sample of tissue is removed with preservation of the histological architecture of the tissues cells, the procedure is called an incisional biopsy or core biopsy. When a sample of tissue or fluid is removed with a needle in such a way that cells are removed without preserving the histological architecture of the tissue cells, the procedure is called a needle aspiration biopsy. Biopsies are most commonly performed for insight into possible cancerous and inflammatory conditions., Xeroderma pigmentosum (XP) is a rare autosomal recessive genetic disorder of DNA repair in which the ability to repair damage caused by ultraviolet (UV) light is deficient. In extreme cases, "all" exposure to sunlight must be forbidden, no matter how small; as such, individuals with the disease are often colloquially referred to as "Moon child". Multiple basal cell carcinomas (basaliomas) and other skin malignancies frequently occur at a young age in those with XP; metastatic malignant melanoma and squamous cell carcinoma are the two most common causes of death in XP victims. This disease is present in both genders and in all races, with an incidence of 1:250,000 in the United States. XP is roughly six times more common in Japanese people than in other groups., Ivan Yevhenovych Vyshnevskyi ( Ukrainian :    , Russian :    ; born 21 February 1957 in the village of Chortoryia ( today 's Myrolyubivka , Ternopil Raion ) ; died 11 May 1996 in Dnipropetrovsk of melanoma ) was a Ukrainian footballer . He earned 6 caps for the USSR national football team , making his debut on 25 January 1985 in a friendly against Yugoslavia . He was selected for the UEFA Euro 1988 squad , but did not play in any games at the tournament . He is from the region that once belonged to Winiowiecki family that had estates near Zboriv where the village of Vyshnivets is located ., Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Not all tumors are cancerous; benign tumors do not spread to other parts of the body. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss and a change in bowel movements. While these symptoms may indicate cancer, they may have other causes. Over 100 types of cancers affect humans.
Tobacco use is the cause of about 22% of cancer deaths. Another 10% is due to obesity, poor diet, lack of physical activity and drinking alcohol. Other factors include certain infections, exposure to ionizing radiation and environmental pollutants. In the developing world nearly 20% of cancers are due to infections such as hepatitis B, hepatitis C and human papillomavirus (HPV). These factors act, at least partly, by changing the genes of a cell. Typically many genetic changes are required before cancer develops. Approximately 510% of cancers are due to inherited genetic defects from a person's parents. Cancer can be detected by certain signs and symptoms or screening tests. It is then typically further investigated by medical imaging and confirmed by biopsy.
Many cancers can be prevented by not smoking, maintaining a healthy weight, not drinking too much alcohol, eating plenty of vegetables, fruits and whole grains, vaccination against certain infectious diseases, not eating too much processed and red meat, and avoiding too much sunlight exposure. Early detection through screening is useful for cervical and colorectal cancer. The benefits of screening in breast cancer are controversial. Cancer is often treated with some combination of radiation therapy, surgery, chemotherapy, and targeted therapy. Pain and symptom management are an important part of care. Palliative care is particularly important in people with advanced disease. The chance of survival depends on the type of cancer and extent of disease at the start of treatment. In children under 15 at diagnosis the five-year survival rate in the developed world is on average 80%. For cancer in the United States the average five-year survival rate is 66%.
In 2012 about 14.1 million new cases of cancer occurred globally (not including skin cancer other than melanoma). It caused about 8.2 million deaths or 14.6% of human deaths. The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer and stomach cancer. In females, the most common types are breast cancer, colorectal cancer, lung cancer and cervical cancer. If skin cancer other than melanoma were included in total new cancers each year it would account for around 40% of cases. In children, acute lymphoblastic leukaemia and brain tumors are most common except in Africa where non-Hodgkin lymphoma occurs more often. In 2012, about 165,000 children under 15 years of age were diagnosed with cancer. The risk of cancer increases significantly with age and many cancers occur more commonly in developed countries. Rates are increasing as more people live to an old age and as lifestyle changes occur in the developing world. The financial costs of cancer were estimated at $1.16 trillion US dollars per year as of 2010.
Definitions.
Cancers are a large family of diseases that involve abnormal cell growth with the potential to invade or spread to other parts of the body. They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often form a mass or lump, but may be distributed diffusely., A lymph node or lymph gland, is an ovoid or kidney-shaped organ of the lymphatic system, and of the adaptive immune system, that is widely present throughout the body. They are linked by the lymphatic vessels as a part of the circulatory system. Lymph nodes are major sites of B and T lymphocytes, and other white blood cells. Lymph nodes are important for the proper functioning of the immune system, acting as filters for foreign particles and cancer cells. Lymph nodes do not have a detoxification function, which is primarily dealt with by the liver and kidneys., Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is therapy using ionizing radiation, generally as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology., Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes. Melanomas typically occur in the skin but may rarely occur in the mouth, intestines, or eye. In women they most commonly occur on the legs, while in men they are most common on the back. Sometimes they develop from a mole with concerning changes including an increase in size, irregular edges, change in color, itchiness, or skin breakdown.
The primary cause of melanoma is ultraviolet light (UV) exposure in those with low levels of skin pigment. The UV light may be from either the sun or from other sources, such as tanning devices. About 25% develop from moles. Those with many moles, a history of affected family members, and who have poor immune function are at greater risk. A number of rare genetic defects such as xeroderma pigmentosum also increase risk. Diagnosis is by biopsy of any concerning skin lesion.
Using sunscreen and avoiding UV light may prevent melanoma. Treatment is typically removal by surgery. In those with slightly larger cancers, nearby lymph nodes may be tested for spread. Most people are cured if spread has not occurred. For those in whom melanoma has spread, immunotherapy, biologic therapy, radiation therapy, or chemotherapy may improve survival. With treatment the five-year survival rates in the United States is 98% among those with localized disease and 17% among those in whom spread has occurred. The likelihood that it will come back or spread depends how thick the melanoma is, how fast the cells are dividing, and whether or not the overlying skin has broken down.
Melanoma is the most dangerous type of skin cancer. Globally, in 2012, it occurred in 232,000 people and resulted in 55,000 deaths. Australia and New Zealand have the highest rates of melanoma in the world. There are also high rates in Northern Europe and North America, while it is less common in Asia, Africa, and Latin America. Melanoma is more common in men than women. Melanoma has become more common since the 1960s in areas that are mostly Caucasian., Subject: ivan vyshnevskyi, Relation: cause_of_death, Options: (A) bleeding (B) breast cancer (C) cancer (D) carcinoma (E) disease (F) hepatitis (G) lung cancer (H) melanoma (I) old age (J) skin cancer (K) tumor
skin cancer

Context: Noricum is the Latin name for a Celtic kingdom, or federation of tribes, that included most of modern Austria and part of Slovenia. In the first century AD, it became a province of the Roman Empire. Its borders were the Danube to the north, "Raetia" and "Vindelicia" to the west, Pannonia to the east and southeast, and "Italia" ("Venetia et Histria") to the south. The kingdom was founded around 400 BC, and had its capital at the royal residence at Virunum on the Magdalensberg., Late Antiquity is a periodization used by historians to describe the time of transition from classical antiquity to the Middle Ages in mainland Europe, the Mediterranean world, and the Middle East. The development of the periodization has generally been accredited to historian Peter Brown, after the publication of his seminal work "The World of Late Antiquity" (1971). Precise boundaries for the period are a continuing matter of debate, but Brown proposes a period between the 3rd and 8th centuries AD. Generally, it can be thought of as from the end of the Roman Empire's Crisis of the Third Century (c. 235  284) to, in the East, the early Islamic period (7th9th centuries), following the Muslim conquests in the mid7th century. In the West the end was earlier, with the start of the Early Medieval period typically placed in the 6th century, or earlier on the Western edges of the empire., The Iron Age is an archaeological era, referring to a period of time in the prehistory and protohistory of the Old World (Afro-Eurasia) when the dominant toolmaking material was iron. It is commonly preceded by the Bronze Age in Europe and Asia with exceptions and the Stone Age in Africa. Meteoric iron has been used by humans since at least 3200 BC, but ancient iron production did not become widespread until the ability to smelt iron ore, remove impurities and regulate the amount of carbon in the alloy were developed. The start of the Iron Age proper is considered by many to fall between around 1200 BC to 600 BC, depending on the region. In most parts of the world, its end is defined by the widespread adoption of writing, and therefore marks the transition from prehistory to history., Gaul (Latin: "Gallia") was a region of Western Europe during the Iron Age that was inhabited by Celtic tribes, encompassing present day France, Luxembourg, Belgium, most of Switzerland, Northern Italy, as well as the parts of the Netherlands, Central Italy and Germany on the west bank of the Rhine. It covered an area of 190,800 mi² or 494,169 km². According to the testimony of Julius Caesar, Gaul was divided into three parts: Gallia Celtica, Belgica and Aquitania.
Archaeologically, the Gauls were bearers of the La Tène culture, which extended across all of Gaul, as well as east to Raetia, Noricum, Pannonia and southwestern Germania during the 5th to 1st centuries BC.
During the 2nd and 1st centuries BC, Gaul fell under Roman rule: Gallia Cisalpina was conquered in 203 BC and Gallia Narbonensis in 123 BC. Gaul was invaded after 120 BC by the Cimbri and the Teutons, who were in turn defeated by the Romans by 103 BC. Julius Caesar finally subdued the remaining parts of Gaul in his campaigns of 58 to 51 BC., The Visigoths were the western branches of the nomadic tribes of Germanic peoples referred to collectively as the Goths. These tribes flourished and spread during the late Roman Empire in Late Antiquity, or the Migration Period. The Visigoths emerged from earlier Gothic groups (possibly the Thervingi) who had invaded the Roman Empire beginning in 376 and had defeated the Romans at the Battle of Adrianople in 378. Relations between the Romans and the Visigoths were variable, alternately warring with one another and making treaties when convenient. The Visigoths invaded Italy under Alaric I and sacked Rome in 410. After the Visigoths sacked Rome, they began settling down, first in southern Gaul and eventually in Spain and Portugal, where they founded the Visigothic Kingdom and maintained a presence from the 5th to the 8th centuries AD., Flavius Ricimer (; c. 405  August 18, 472) was a Romanized Germanic general who effectively ruled the remaining territory of the Western Roman Empire from 456 until his death in 472. Deriving his power from his position as "magister militum" of the Western Empire, Ricimer exercised political control through a series of puppet emperors., Aegidius ( died 464 or 465 ) was a Gallo - Roman warlord of northern Gaul . He had been promoted as magister militum in Gaul under Aëtius around 450 . An ardent supporter of Majorian , Aegidius rebelled when Ricimer deposed Majorian , engaging in several campaigns against the Visigoths and creating a Roman rump state that came to be known as the Domain of Soissons . After winning an important victory over the Visigoths he died suddenly , and was succeeded by his son Syagrius . Ralph Mathisen points out the name of Aegidius ' son , Syagrius , `` would suggest that he was related to the Syagrii of Lyons , one of the oldest , most aristocratic families of Gaul . Aegidius , in fact , has been proposed as a grandson of Flavius Afranius Syagrius , consul in 382 '' . Other Syagrii Mathisen lists with a connection to Gaul are a great - grandson of Afranius , who had an estate at Taionnacus near Lyons , and a wealthy Syagria of Lyons who was described by Magnus Felix Ennodius as thesaurus ecclesiae ., Flavius Julius Valerius Majorianus (c. AD 420  August 7, 461), usually known simply as Majorian, was the Western Roman Emperor from 457 to 461., Syagrius (430  486 or 487) was the last Roman military commander in Gaul, whose defeat by king Clovis I of the Franks is considered the end of Western Roman rule outside of Italy. He came to this position through inheritance, for his father was Aegidius, the last Roman "magister militum per Gallias". Syagrius preserved his father's rump state between the Somme and the Loire around Soissons after the collapse of central rule in the Western Empire, a domain Gregory of Tours called the "Kingdom" of Soissons. Syagrius governed this Gallo-Roman enclave from the death of his father in 464 until 486, when he was defeated in battle by Clovis I., The Roman Empire (Koine and Medieval Greek:   , tr. ) was the post-Roman Republic period of the ancient Roman civilization, characterized by government headed by emperors and large territorial holdings around the Mediterranean Sea in Europe, Africa and Asia. The city of Rome was the largest city in the world BC AD, with Constantinople (New Rome) becoming the largest around 500 AD, and the Empire's populace grew to an estimated 50 to 90 million inhabitants (roughly 20% of the world's population at the time). The 500-year-old republic which preceded it was severely destabilized in a series of civil wars and political conflict, during which Julius Caesar was appointed as perpetual dictator and then assassinated in 44 BC. Civil wars and executions continued, culminating in the victory of Octavian, Caesar's adopted son, over Mark Antony and Cleopatra at the Battle of Actium in 31 BC and the annexation of Egypt. Octavian's power was then unassailable and in 27 BC the Roman Senate formally granted him overarching power and the new title "Augustus", effectively marking the end of the Roman Republic., Soissons is a commune in the Aisne department in Hauts-de-France in northern France, located on the Aisne River, about northeast of Paris. It is one of the most ancient towns of France, and is probably the ancient capital of the Suessiones. Soissons is also the see of an ancient Roman Catholic diocese, whose establishment dates from about 300., Gaius Julius Caesar (13 July 100 BC  15 March 44 BC), known as Julius Caesar, was a Roman politician, general, and notable author of Latin prose. He played a critical role in the events that led to the demise of the Roman Republic and the rise of the Roman Empire., Subject: aegidius, Relation: floruit, Options: (A) 100 (B) 120 (C) 1200 (D) 1971 (E) 300 (F) 400 (G) 456 (H) 457 (I) 464 (J) 500 (K) 600
457

Context: The River Thame is a river in Southern England. It is a tributary of the River Thames., Charing Cross denotes the junction of Strand, Whitehall and Cockspur Street, just south of Trafalgar Square in central London. It gives its name to several landmarks, including Charing Cross railway station, one of the main London rail terminals., Kew is a suburban district in the London Borough of Richmond upon Thames , 1.5 miles ( 2.4 km ) north - east of Richmond and 7.1 miles ( 11.4 km ) west by south - west of Charing Cross ; its population at the 2011 Census was 11,436 . Kew is the location of the Royal Botanic Gardens ( `` Kew Gardens '' ) , now a World Heritage Site , which includes Kew Palace . Kew is also the home of important historical documents such as Domesday Book , which is on public display at The National Archives . Successive Tudor , Stuart and Georgian monarchs maintained links with Kew . During the French Revolution , many refugees established themselves there and it was the home of several artists in the 18th and 19th centuries . Since 1965 Kew has incorporated the former area of North Sheen which includes St Philip and All Saints , the first barn church consecrated in England . It is now in a combined Church of England ecclesiastical parish with St Luke 's Church , Kew . Today , Kew is an expensive residential area because of its suburban hallmarks . Among these are sports - and - leisure open spaces , schools , transport links , architecture , restaurants , no high rise buildings , modest road sizes , trees and gardens . Most of Kew developed in the late 19th century , following the arrival of the District line of the Underground . Further development took place in the 1920s and 1930s when new houses were built on the market gardens of North Sheen and in the first decade of the 21st century when considerably more river - fronting flats and houses were constructed by the Thames on land formerly owned by Thames Water ., Thame is a market town and civil parish in Oxfordshire, about east of the city of Oxford and southwest of the Buckinghamshire town of Aylesbury. It derives its toponym from the River Thame which flows along the north side of the town. The parish includes the hamlet of Moreton south of the town. The 2011 Census recorded the parish's population as 11,561., The London Borough of Richmond upon Thames in south-west London, England, forms part of Outer London and is the only London borough on both sides of the River Thames. It was created in 1965 when three smaller council areas amalgamated under the London Government Act 1963. It is governed by Richmond upon Thames London Borough Council., England is a country that is part of the United Kingdom. It shares land borders with Scotland to the north and Wales to the west. The Irish Sea lies northwest of England and the Celtic Sea lies to the southwest. England is separated from continental Europe by the North Sea to the east and the English Channel to the south. The country covers five-eighths of the island of Great Britain (which lies in the North Atlantic) in its centre and south; and includes over 100 smaller islands such as the Isles of Scilly, and the Isle of Wight., Whitehall is a road in the City of Westminster, Central London, which forms the first part of the A3212 road from Trafalgar Square to Chelsea. It is the main thoroughfare running south from Trafalgar Square towards Parliament Square. The street is recognised as the centre of Her Majesty's Government and is lined with numerous departments and ministries including the Ministry of Defence, Horse Guards and the Cabinet Office. Consequently, the name "Whitehall" is used as a metonym for British central governmental administration, and the geographic name for the surrounding area., The River Thames is a river that flows through southern England. At , it is the longest river entirely in England and the second longest in the United Kingdom, after the River Severn. It also flows through Oxford (where it is called Isis), Reading, Henley-on-Thames and Windsor. The lower reaches of the river are called the Tideway, derived from its long tidal reach up to Teddington Lock. It rises at Thames Head in Gloucestershire, and flows into the North Sea via the Thames Estuary. The Thames drains the whole of Greater London. , Subject: kew, Relation: located_next_to_body_of_water, Options: (A) irish sea (B) main (C) north sea (D) river thames

river thames