Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

[Q]: We describe a patient with transitional cell carcinoma of the renal pelvis who developed respiratory dysfunction and an abnormal chest x-ray with diffuse interstitial opacities while on chemotherapy with piritrexim, a methotrexate analog.
[A]: adverse drug event


[Q]: Recent efforts have focused on heightened surveillance to detect contamination before transfusion to limit recipient morbidity and mortality.
[A]: non-adverse drug event


[Q]: The mechanism of the interaction is probably inhibition of glipizide metabolism rather than protein-binding displacement.
[A]:
non-adverse drug event