TASK DEFINITION: Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.
PROBLEM: If true, it would be a profound leap of science and ethics. A U.S. scientist said he took part in the work in China, but this kind of gene editing is banned in the United States because the DNA changes can pass to future generations and it risks harming other genes. Many mainstream scientists think it’s too unsafe to try, and some denounced the Chinese report as human experimentation. The researcher, He Jiankui of Shenzhen, said he altered embryos for seven couples during fertility treatments, with one pregnancy resulting thus far. He said his goal was not to cure or prevent an inherited disease, but to try to bestow a trait that few people naturally have — an ability to resist possible future infection with HIV, the AIDS virus. He said the parents involved declined to be identified or interviewed, and he would not say where they live or where the work was done. There is no independent confirmation of He’s claim, and it has not been published in a journal, where it would be vetted by other experts. He revealed it Monday in Hong Kong to one of the organizers of an international conference on gene editing that is set to begin Tuesday, and earlier in exclusive interviews with The Associated Press. “I feel a strong responsibility that it’s not just to make a first, but also make it an example,” He told the AP. “Society will decide what to do next” in terms of allowing or forbidding such science. Some scientists were astounded to hear of the claim and strongly condemned it. It’s “unconscionable ... an experiment on human beings that is not morally or ethically defensible,” said Dr. Kiran Musunuru, a University of Pennsylvania gene editing expert and editor of a genetics journal. “This is far too premature,” said Dr. Eric Topol, who heads the Scripps Research Translational Institute in California. “We’re dealing with the operating instructions of a human being. It’s a big deal.” However, one famed geneticist, Harvard University’s George Church, defended attempting gene editing for HIV, which he called “a major and growing public health threat.” “I think this is justifiable,” Church said of that goal. In recent years scientists have discovered a relatively easy way to edit genes, the strands of DNA that govern the body. The tool, called CRISPR-cas9, makes it possible to operate on DNA to supply a needed gene or disable one that’s causing problems. It’s only recently been tried in adults to treat deadly diseases, and the changes are confined to that person. Editing sperm, eggs or embryos is different — the changes can be inherited. In the U.S., it’s not allowed except for lab research. China outlaws human cloning but not specifically gene editing. He Jiankui (HEH JEE’-an-qway), who goes by “JK,” studied at Rice and Stanford universities in the U.S. before returning to his homeland to open a lab at Southern University of Science and Technology of China in Shenzhen, where he also has two genetics companies. The university said He’s work “seriously violated academic ethics and standards” and planned to investigate. A spokesman for He confirmed that he has been on leave from teaching since early this year, but he remains on the faculty and has a lab at the school. The U.S. scientist who worked with him on this project after He returned to China was physics and bioengineering professor Michael Deem, who was his adviser at Rice in Houston. Deem also holds what he called “a small stake” in — and is on the scientific advisory boards of — He’s two companies. The Chinese researcher said he practiced editing mice, monkey and human embryos in the lab for several years and has applied for patents on his methods. He said he chose embryo gene editing for HIV because these infections are a big problem in China. He sought to disable a gene called CCR5 that forms a protein doorway that allows HIV, the virus that causes AIDS, to enter a cell. All of the men in the project had HIV and all of the women did not, but the gene editing was not aimed at preventing the small risk of transmission, He said. The fathers had their infections deeply suppressed by standard HIV medicines and there are simple ways to keep them from infecting offspring that do not involve altering genes. Instead, the appeal was to offer couples affected by HIV a chance to have a child that might be protected from a similar fate. He recruited couples through a Beijing-based AIDS advocacy group called Baihualin. Its leader, known by the pseudonym “Bai Hua,” told the AP that it’s not uncommon for people with HIV to lose jobs or have trouble getting medical care if their infections are revealed. Here is how He described the work: The gene editing occurred during IVF, or lab dish fertilization. First, sperm was “washed” to separate it from semen, the fluid where HIV can lurk. A single sperm was placed into a single egg to create an embryo. Then the gene editing tool was added. When the embryos were 3 to 5 days old, a few cells were removed and checked for editing. Couples could choose whether to use edited or unedited embryos for pregnancy attempts. In all, 16 of 22 embryos were edited, and 11 embryos were used in six implant attempts before the twin pregnancy was achieved, He said. Tests suggest that one twin had both copies of the intended gene altered and the other twin had just one altered, with no evidence of harm to other genes, He said. People with one copy of the gene can still get HIV, although some very limited research suggests their health might decline more slowly once they do. Several scientists reviewed materials that He provided to the AP and said tests so far are insufficient to say the editing worked or to rule out harm. They also noted evidence that the editing was incomplete and that at least one twin appears to be a patchwork of cells with various changes. “It’s almost like not editing at all” if only some of certain cells were altered, because HIV infection can still occur, Church said. Church and Musunuru questioned the decision to allow one of the embryos to be used in a pregnancy attempt, because the Chinese researchers said they knew in advance that both copies of the intended gene had not been altered. “In that child, there really was almost nothing to be gained in terms of protection against HIV and yet you’re exposing that child to all the unknown safety risks,” Musunuru said. The use of that embryo suggests that the researchers’ “main emphasis was on testing editing rather than avoiding this disease,” Church said. Even if editing worked perfectly, people without normal CCR5 genes face higher risks of getting certain other viruses, such as West Nile, and of dying from the flu. Since there are many ways to prevent HIV infection and it’s very treatable if it occurs, those other medical risks are a concern, Musunuru said. There also are questions about the way He said he proceeded. He gave official notice of his work long after he said he started it — on Nov. 8, on a Chinese registry of clinical trials. It’s unclear whether participants fully understood the purpose and potential risks and benefits. For example, consent forms called the project an “AIDS vaccine development” program. The Rice scientist, Deem, said he was present in China when potential participants gave their consent and that he “absolutely” thinks they were able to understand the risks. Deem said he worked with He on vaccine research at Rice and considers the gene editing similar to a vaccine. “That might be a layman’s way of describing it,” he said. Both men are physics experts with no experience running human clinical trials. The Chinese scientist, He, said he personally made the goals clear and told participants that embryo gene editing has never been tried before and carries risks. He said he also would provide insurance coverage for any children conceived through the project and plans medical follow-up until the children are 18 and longer if they agree once they’re adults. Further pregnancy attempts are on hold until the safety of this one is analyzed and experts in the field weigh in, but participants were not told in advance that they might not have a chance to try what they signed up for once a “first” was achieved, He acknowledged. Free fertility treatment was part of the deal they were offered. He sought and received approval for his project from Shenzhen Harmonicare Women’s and Children’s Hospital, which is not one of the four hospitals that He said provided embryos for his research or the pregnancy attempts. Some staff at some of the other hospitals were kept in the dark about the nature of the research, which He and Deem said was done to keep some participants’ HIV infection from being disclosed. “We think this is ethical,” said Lin Zhitong, a Harmonicare administrator who heads the ethics panel. Any medical staff who handled samples that might contain HIV were aware, He said. An embryologist in He’s lab, Qin Jinzhou, confirmed to the AP that he did sperm washing and injected the gene editing tool in some of the pregnancy attempts. The study participants are not ethicists, He said, but “are as much authorities on what is correct and what is wrong because it’s their life on the line.” “I believe this is going to help the families and their children,” He said. If it causes unwanted side effects or harm, “I would feel the same pain as they do and it’s going to be my own responsibility.” ___ AP science writer Christina Larson, video journalist Emily Wang and researcher Fu Ting contributed to this report from Beijing and Shenzhen, China. ___ This Associated Press series was produced in partnership with the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.

SOLUTION: Chinese researcher claims first gene-edited babies.

PROBLEM: The third-term Democrat touted past achievements and trumpeted a long list of policy initiatives, many of which he previewed in a series of announcements over the past month. Cuomo also stressed the need for fiscal restraint, with the state staring at a $6 billion budget gap, caused largely by soaring Medicaid spending. The agenda Cuomo outlined in the speech includes plans for expanding anti-discrimination protections in the state constitution, an overhaul for New York City’s Penn Station and a proposed ban on foam food containers. Cuomo also outlined another ban that would cover marketing flavored e-cigarettes to children, initiatives intended to lower the cost of prescription drugs, guaranteed paid sick leave time for more New York workers and expanded universal pre-kindergarten. “New York at her best is the progressive capitol of the nation, and we must fulfill that destiny again this year,” Cuomo said. Cuomo delivered his address at the Empire State Plaza Convention Center in downtown Albany to an audience of members of the Legislature and top politicians from around the state. The speech kicked off a legislative session running through June 2. The governor’s address comes after several episodes of violence targeting Jewish people, including an attack by a man who stormed inside the home of a Monsey rabbi, Chaim Rottenberg, and stabbed five people at a Hanukkah celebration. Rottenberg delivered a blessing before Cuomo’s address and called for tolerance. “I will never forget the horror of that night,” Rottenberg said. “But I will also never forget how we continue to celebrate after that day, how we continue to rejoice in the miracle of Hanukkah. I will never forget the resilience on display that night and in the following days, the resilience of Jewish people and the resilience of New York.” Cuomo is proposing a new law targeted at domestic terrorism and said New York would be the first state in the U.S. to enact such legislation. The new law would apply to crimes in which at least one person died and victims were targeted by their race, religion and gender, among other topics. Cuomo called the attack “intolerable” and pledged the state won’t stand for it. “They attacked me, and they attacked you,” Cuomo said. “These are the times, my friends, when New York state is called upon to lead to set a course for a troubled nation searching its way through the fog of confusion,” he said. In a policy briefing book that accompanied his speech, Cuomo said his proposal to legalize marijuana would limit the sale of cannabis products to adults over age 21. But he only briefly mentioned his legalization proposal in his address Wednesday, to tepid applause. A similar proposal to legalize recreational marijuana failed last year among disagreements over funding and hesitation from suburban Democrats. Lawmakers instead scaled back penalties for possession of small amounts of marijuana and created a process for expungement. Cuomo has declared “Making Progress Happen” as his slogan for 2020. But any progress will have to come while the state is grappling with a budget gap fueled by soaring Medicaid costs. Debate over how to handle the shortfall is expected to color virtually every policy debate this year. Hundreds of activists rallied in Albany demanding action on issues including the state’s ambitious climate change goals. Cuomo called climate change the “transcendent threat of our times” and proposed sending voters a $3 billion bond in November to fund a flood reduction and habitat restoration program he is calling Restore Mother Nature. “Because no economic strategy, no social justice reform, no education policy will be worth a damn if we don’t have a planet to live on,” he said. Cuomo has yet to share many details about his plans to address soaring costs of the Medicaid program, which serves over 6 million people. The governor called Wednesday for improved accountability in the Medicaid system, saying safeguards were needed to limit potential overspending on the program by municipalities. More details of how the administration plans to address the funding gap may have to wait for his budget proposal, expected in mid-January. Cuomo has cautioned against overspending while pledging not to raise taxes. That budget-conscious message could clash with more left-leaning lawmakers and advocates who want to balance the budget with new taxes on the wealthy. The governor’s party has seen big political wins in recent years, even as some long-time Democratic incumbents have lost to more left-wing challengers. But Cuomo argued Wednesday true progressive politics must be grounded in “reality” and champion results over rhetoric. Republicans, who have seen their clout diminish in Albany, say they will hold down spending and resist new taxes. Republican leaders including state GOP chairman Nick Langworthy criticized the governor for failing to address the budget deficit as well as a mounting debate over bail reforms enacted last year. Cuomo and other Democrats have signaled they are open to making changes to the statute. In his preview announcements over the past month, Cuomo has released proposals to ban untraceable guns, study high speed rail, allow liquor sales in movie theaters, require the use of American-made steel and iron on infrastructure projects and ease rules for prosecuting sexual assault involving intoxicated victims, among other initiatives. Assembly Speaker Carl Heastie, a Democrat, said lawmakers have their own priorities this year, including working to increase school aid, affordable housing, infrastructure, local businesses, rural hospitals and mental healthcare.

SOLUTION: Cuomo’s 2020 agenda: Fight hate, help planet, legalize pot.

PROBLEM: On March 21 2020, Facebook and Twitter users began sharing purportedly official guidelines for COVID-19 and sex, attributed to the New York City Health Department:the NYC department of health says that during the COVID-19 pandemic “you are your safest sex partner”, so i’m just trying to spread the word pic.twitter.com/oUHIqRKlfY— Tommy Siegel (@TommySiegel) March 23, 2020OMG I had a mouthful of ass while reading this NYC Health guide to Covid-safe Sex and of course, responsible New Yorker that I am, I IMMEDIATELY spat it out. Is there a five second rule? #oneonethousandtwoonethousand pic.twitter.com/QpDmt4hJU0— BD WONG (@wongbd) March 23, 2020Highlights of NYC’s government official guide to having safe sex during these times include:-“wash your hands (and any sex toys)”-Rimming (mouth on anus) might spread COVID-19.”-“You are your safest sex partner.” pic.twitter.com/M0VzSVP75I— chris (@ichrisherrero) March 22, 2020The NYC Health Department’s guide to sex during the COVID-19 outbreak is a gem. https://t.co/pX3nrHzrjv— Sasha Perigo (@sashaperigo) March 21, 2020Facebook’s iterations of the share bore the NYC Health logo, but typically linked to a Google Docs PDF with no clear attribution. That document was unassumingly titled “covid-sex-guidance.pdf,” and it began by urging all New York City residents to stay home in an effort to reduce the spread of highly infectious coronavirus strain COVID-19.Immediately thereafter, it addressed whether it was safe to have sex at all while coronavirus was spreading:Sex and Coronavirus Disease 2019 (COVID-19)All New Yorkers should stay home and minimize contact with others to reduce the spread of COVID-19.But can you have sex? Here are some tips for how to enjoy sex and to avoid spreading COVID-19.1. Know how COVID-19 spreads. • You can get COVID-19 from a person who has it. o The virus can spread to people who are within about 6 feet of a person with COVID-19 when that person coughs or sneezes. o The virus can spread through direct contact with their saliva or mucus. • We still have a lot to learn about COVID-19 and sex. o COVID-19 has been found in feces of people who are infected with the virus. o COVID-19 has not yet been found in semen or vaginal fluid. o We know that other coronaviruses do not efficiently transmit through sex.Amorous New York City residents were first advised to understand how coronavirus COVID-19 spreads, and detailed how as of March 2020 — still in the first weeks of a global pandemic — comparatively little is still known about about SARS-nCoV-2. In the document’s second point, it went on to provide perhaps the most discussed of all the advice on the page (emphasis ours):2. Have sex with people close to you. • You are your safest sex partner. Masturbation will not spread COVID-19, especially if you wash your hands (and any sex toys) with soap and water for at least 20 seconds before and after sex. • The next safest partner is someone you live with. Having close contact — including sex — with only a small circle of people helps prevent spreading COVID-19. • You should avoid close contact — including sex — with anyone outside your household. If you do have sex with others, have as few partners as possible and avoid group sex. • If you usually meet your sex partners online or make a living by having sex, consider taking a break from in-person dates. Video dates, sexting or chat rooms may be options for you.City residents were, to put it bluntly, advised to stay home and masturbate. However, if that wasn’t sufficiently stimulating, household members were deemed the safest option with whom to have sex.Group sex was, perhaps predictably, not recommended during the pandemic.While Facebook shares linked to a Google Docs page, tweets about the NYC guidelines for safe sex and COVID-19 tended to be in screenshot form. It was uncommon to see anything with a direct link back to an official, verified NYC.gov account. We checked the official NYC Department of Health Facebook page and did not see the COVID-19 sex guidelines shared there.Twitter was another story, though:Soooo …Since we’re all staying home, you might be wondering what to do with all that extra time. We got you, NYC. 😘Read our guide on how to enjoy sex and avoid spreading #COVID19: https://t.co/fjjkfGgf3C— nycHealthy – STAY HOME NYC (@nycHealthy) March 22, 2020In addition to a link to a NYC.gov page, the tweet read:Soooo …Since we’re all staying home, you might be wondering what to do with all that extra time. We got you, NYC. 😘Read our guide on how to enjoy sex and avoid spreading #COVID19: https://on.nyc.gov/3agKh8ULinked was the same circulating document [PDF], with “covid-sex-guidance.pdf” and “Sex and Coronavirus Disease 2019 (COVID-19)” as titles. The officially issued guidance matched the aforementioned screengrabs and documents, right down to “you are your safest sex partner” and “masturbation will not spread COVID-19.” The circulating document is authentic — despite the fact it s spreading primarily via screenshots or an unattributed Google Docs page.

SOLUTION:
New York City Health (NYC Health) issued official guidelines for sex during a global coronavirus pandemic.