In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Q: Paragraph: Hepatitis C Virus (HCV) infects 2% of the world's population and is the leading cause of liver disease and liver transplantation. It poses a serious and growing worldwide public health problem that will only be partially addressed with the introduction of new antiviral therapies. However, these treatments will not prevent re-infection particularly in high risk populations. The introduction of a HCV vaccine has been predicted, using simulation models in a high risk population, to have a significant effect on reducing the incidence of HCV. A vaccine with 50 to 80% efficacy targeted to high-risk intravenous drug users could dramatically reduce HCV incidence in this population. Virus like particles (VLPs) are composed of viral structural proteins which self-assemble into non-infectious particles that lack genetic material and resemble native viruses. Thus, VLPs represent a safe and highly immunogenic vaccine delivery platform able to induce potent adaptive immune responses. Currently, many VLP-based vaccines have entered clinical trials, while licensed VLP vaccines for hepatitis B virus (HBV) and human papilloma virus (HPV) have been in use for many years. The HCV core, E1 and E2 proteins can self-assemble into immunogenic VLPs while inclusion of HCV antigens into heterogenous (chimeric) VLPs is also a promising approach. These VLPs are produced using different expression systems such as bacterial, yeast, mammalian, plant, or insect cells. Here, this paper will review HCV VLP-based vaccines and their immunogenicity in animal models as well as the different expression systems used in their production. 
 Title: Preclinical Development and Production of Virus-Like Particles As Vaccine Candidates for Hepatitis C

A: True
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Q: Paragraph: Background: Chronic Hepatitis B (CHB) remains a major problem for global public health. Viral persistence and immune defects are the two major reasons for CHB, and it was hypothesized that based on a transient clearance of serum viral DNA and HBsAg "window stage", active immunization against hepatitis B virus (HBV) might initiate effective host immune responses versus HBV to achieve functional cure of CHB. Methods: Two experimental mouse models that mice hydrodynamic injected HBV DNA or infected with recombinant AAV/HBV were used. The "sandwich" therapeutic effect by using a potent human anti-HBsAg neutralizing monoclonal antibody (G12) in combination with antiviral drug tenofovir disoproxil fumarate (TDF), followed by active immunization with HBsAg-HBsAb (mYIC) was evaluated. Findings: A single G12 injection rapidly cleared serum HBsAg in HDI-HBV carrier mice, with a synergistic effect in decreasing viral DNA load when TDF was given orally. When both serum viral DNA and HBsAg load became low or undetectable, mYIC was administered. A more effective clearance of viral DNA and HBsAg was observed and serum HBsAb was developed only in these "sandwich"-treated mice. Efficient intrahepatic anti-HBV immune responses were also observed in these mice, including the formation of aggregates of myeloid cells with CD8 + T cells and increased TNF-α, granzyme B production. The "sandwich" combination therapy not only efficiently decreased HBsAg and HBV DNA levels but also induced effective cellular and humoral immunity, which may result in functional cure of CHB. Research in context section Persistence of HBV cccDNA and various host immune defects were shown as the two main obstacles for HBV clearance. Blocking a single target will not be sufficient to achieve functional cure of CHB. A very small percentage of CHB patients could attain "functional cure" by antiviral treatment fol- * Corresponding authors. .cn (Z. Yuan). lowed by interferon therapy. Therapeutic vaccination for CHB showed substantial efficacy. A humanized HBsAb G12 could efficiently block HBV infection and decrease HBsAg level in mice model. This research showed that when both serum viral DNA and HB-sAg load became low or undetectable by antiviral and HBsAb treatment, therapeutic vaccine (mYIC) add on induced effective, host humoral and intrahepatic cellular anti-HBV immune responses, with more rapid and efficient clearance of HBV and HBsAg. Based on optimized antiviral treatment with potent human HB-sAb to rapidly decrease serum HBsAg, followed by boosting host with active immunization provides a novel strategy for functional cure of CHB. 
 Title: Evaluation of antiviral -passive -active immunization ("sandwich") therapeutic strategy for functional cure of chronic hepatitis B in mice

A: True
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Q: Paragraph: To celebrate the 60th anniversary of SCIENCE CHINA, the second issue of Science China Life Sciences (2010) focuses on immunology, with six articles contributed by immunologists working both in and outside China. The articles review the current position and recent developments in the field of immunology, including tumor necrosis factor (TNF) receptor-associated factor (TRAF) family molecules, innate recognition, plasmacytoid dendritic cells (pDCs), costimulatory molecules, T cells, and humanized mouse models. As early as 1798, the word "vaccination" was coined specifically to describe the injection of smallpox vaccine. In 1880, Louis Pasteur published a paper on Pasteurella septica cholera, heralding the beginning of a new scientific field: Immunology. From then on, Pasteur's germ theory of human infectious disease facilitated the development of various vaccines, leading to a greater understanding of the immune system which, in turn, resulted in the expansion of the field of Immunology. For a century, immunologists around the world have enhanced our understanding of the immune system; from humoral and cellular adaptive immunity to the pattern recognition involved in innate immunity. Alongside great advances due to the expansion of molecular biology over the past decade, Immunology has become a central pillar of the life sciences, developing many branches such as Medical Immunology, Tumor Immunology, Clinical Immunology and Transplantation Immunology. As an integral component of medical science, Immunology plays an important role in deepening the understanding of the pathophysiology of human disease, and also contributes to the development of modern therapeutics to treat infection, autoimmune diseases, allergies and cancer. In recent years, Chinese immunologists have produced many important studies in Immunology. The following reviews provide a brief overview of recent advances in Immunology, highlighting the contributions of leading Chinese immunologists. The first review "TRAF-mediated regulation of immune and inflammatory responses" by Wang et al. [1] focuses on the TRAF family, beginning with a comprehensive introduction to structure and function. Over the past few years, research studies have established a central role of TRAF proteins in inflammation and immunity. The TRAF family plays divergent and non-redundant roles in regulating the many signal transduction pathways involved in innate and adaptive immune responses. These molecules participate in signal transduction by a large number of receptor families, including the TNF receptor family and the Toll-like receptor-interleukin-1 receptor family. The review summarizes the divergent roles played by TRAF proteins in positive and negative regulation of the canonical and non-canonical NF-κB pathways and type I interferon pathways, and also points out many aspects of TRAF biology that, although not clear, may still be of great significance to related research. The second review is entitled "On self-non-self discrimination in pattern recognition" by Liu et al. [2]. The first section of this article discusses the development of immunity from a historical perspective. The second part deals with two different patterns of innate immune recognition. The third part then goes on to summarize the latest advances in the authors' own research into the CD24-SiglecG/10 pathway. According to their studies, the CD24/Siglec 10 pathway discriminates pathogen-associated molecular patterns 
 Title: Recent progress of immunology research in China

A:
False
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