instruction:
Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
question:
Context: In America, when the eighth graders leave the middle school, they are often worried about moving to the high school. It is a hard time for them, but it can be an exciting one as well. To make it easier, students need to get familiar with their school. Even though they've done this already in the middle school, it's still important to find where their classrooms are. Most schools take students to the high school for a visit at the end of their eighth grade year. And, most schools also have a freshman speech for parents and students before the first year begins. Sometimes the main office will give away a map of the school. This can help students and parents to find different places in the school. One way to know your high school more and make new friends is to join a club or play a sport. Schools often offer chances to join different clubs and sports. Fall activities begin in August before the first day of school. If you are not interested in sports, there are clubs for any interest, such as drama, dance, chess, photography, community service, etc. These clubs allow students from different grades. By joining an activity, students can find new friendships, not to mention improving their chances in future college applications . The school office will have a list of activities offered at the school and information on how to join them. What's more, to have a great start to a high school year, students can write down some of their worries, and ask for help from teachers and school workers. 
 Question: When do many schools take students to visit their new high school?
answer:
at the end of their eighth grade year


question:
Context: On July 15, 2009 Nucleosys was announced to be disbanding. 
 Question: What year was the end of Nucleosys?
answer:
2009


question:
Context: Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disorder linked to contractions of the D4Z4 repeat array in the subtelomeric region of chromosome 4q. By comparing genome-wide gene expression data from muscle biopsies of patients with FSHD to those of 11 other neuromuscular disorders, paired-like homeodomain transcription factor 1 (PITX1) was found specifically up-regulated in patients with FSHD. In addition, we showed that the double homeobox 4 gene (DUX4) that maps within the D4Z4 repeat unit was up-regulated in patient myoblasts at both mRNA and protein level. We further showed that the DUX4 protein could activate transient expression of a luciferase reporter gene fused to the Pitx1 promoter as well as the endogenous Pitx1 gene in transfected C2C12 cells. In EMSAs, DUX4 specifically interacted with a 30-bp sequence 5'-CGGATGCTGTCTTCTAATTAGTTTGGACCC-3' in the Pitx1 promoter. Mutations of the TAAT core affected Pitx1-LUC activation in C2C12 cells and DUX4 binding in vitro. Our results suggest that up-regulation of both DUX4 and PITX1 in FSHD muscles may play critical roles in the molecular mechanisms of the disease. 
 Question: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?
answer:

fshd