Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Ex Input:
This Is Not a Film (Persian: In film nist - ) is an Iranian documentary film by Jafar Panahi and Mojtaba Mirtahmasb.

Ex Output:
Who was This Is Not a Film directed by?


Ex Input:
Molecular abnormalities caused by the hybrid Bcr-Abl gene are causally associated with the development and progression of Philadelphia chromosome-positive (Ph(+)) chronic myelogenous leukemia (CML). Imatinib mesylate (STI571), a specific Bcr-Abl tyrosine-kinase signal-transduction inhibitor, has shown encouraging activity in phase I and II studies of CML. Here, we describe the use of imatinib mesylate to treat 75 patients in blast-phase CML (median age, 53 years; 65 with nonlymphoid and 10 with lymphoid blasts), and compare the results with those of a historical control group treated with standard cytarabine-based therapy. Imatinib mesylate was given as oral doses at 300 to 1000 mg per day and was the first salvage therapy for 47 patients. The objective response rate was 52% (39 of 75 patients: 16 had complete and 3 had partial hematologic response; 12 had hematologic improvement; 7 returned to second chronic phase; and 1 had a complete response in extramedullary blastic disease). Response rates were not different between nonlymphoid and lymphoid groups. The cytogenetic response rate was 16% (12 patients: 5 complete, 3 partial [Ph(+) below 35%], and 4 minor [Ph(+), 34% to 90%]). The estimated median overall survival was 6.5 months; the estimated 1-year survival was 22%. Response to therapy (landmark analysis at 8 weeks) was associated with survival prolongation. Compared with standard cytarabine combinations, imatinib mesylate therapy was less toxic and produced a higher response rate (55% versus 29%, P =.001), longer median survival (7 versus 4 months, P =.04), and lower 4-week induction mortality (4% versus 15%, P =.07). Imatinib mesylate is currently being tested in combination with other drugs to improve the prognosis for blast-phase CML.

Ex Output:
What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?


Ex Input:
It seems that great artists and scientists often suffer from mental problems. Both Einstein and Dickens had mental illness. Now scientists have started to look at whether mental illness and genius are linked . Dr. Adele Juda studied 5,000 creative people in Germany. She found there were more people with mental illness in this group than in the general population. Poets had the highest rate of mental illness, followed by musicians, with lower numbers for painters and architects. Other scientists did research which also showed a strong link between mental problems and creativity. But, it did nothing to explain it. Dr. Ruth Richards of Harvard University _ . Instead of studying creative people, she took a group of psychiatric patients and tested them for creativity. The patients got much higher scores than a normal group. Also, the patients' close relatives were much more creative than the patients and a normal group. This suggests that the key to the link between creativity and mental illness is in our genes . But this is a problem. According to Darwinism, harmful genes should be removed. Some scientists believe that evolution has created a balance, where the madness of a few people leads to the development of the whole human race. Geniuses may be mad, bad or just difficult to understand, but their discoveries have improved the world we live in. It seems that a little creative madness is good for us all.

Ex Output:

What is the writer's attitude toward madness?