In this task, you are given a context, a subject, a relation, and many options. Based on the context, from the options select the object entity that has the given relation with the subject. Answer with text (not indexes).

[EX Q]: Context: The Great Lakes region of North America is a bi-national Canadian-American region that includes portions of the eight U.S. states of Illinois, Indiana, Michigan, Minnesota, New York, Ohio, Pennsylvania and Wisconsin as well as the Canadian province of Ontario. The region borders the Great Lakes and forms a distinctive historical, economic, and cultural identity. A portion of the region also encompasses most of the Great Lakes Megalopolis, which extends outside the region to St. Louis, Missouri., State Road 427 ( SR 427 ) is a roughly northeast - southwest two - lane surface road between U.S. Route 6 ( US 6 ) at Waterloo and the Ohio state line east of Hamilton . Fifteen miles in length , it is a child of U.S. Route 27 ( US 27 ) , which is now decommissioned north of Fort Wayne ., Ohio is an Eastern state in the Great Lakes region of the United States. Ohio is the 34th largest by area, the 7th most populous, and the 10th most densely populated of the 50 United States. The state's capital and largest city is Columbus., The Great Lakes (also called the Laurentian Great Lakes, or the Great Lakes of North America) are a series of interconnected freshwater lakes located primarily in the upper mid-east region of North America, on the CanadaUnited States border, which connect to the Atlantic Ocean through the Saint Lawrence River. Consisting of Lakes Superior, Michigan, Huron (or MichiganHuron), Erie, and Ontario, they form the largest group of freshwater lakes on Earth, containing 21% of the world's surface fresh water by volume. The total surface is , and the total volume (measured at the low water datum) is . Due to their sea-like characteristics (rolling waves, sustained winds, strong currents, great depths, and distant horizons) the five Great Lakes have also long been referred to as "inland seas". Lake Superior is the second largest lake in the world by area, and Lake Michigan is the largest lake that is entirely within one country. The southern half of the Great Lakes is bordered by the Great Lakes Megalopolis., Subject: indiana state road 427, Relation: located_in_the_administrative_territorial_entity, Options: (A) canada (B) columbus (C) east (D) erie (E) illinois (F) indiana (G) lakes (H) lawrence (I) new york (J) north america (K) of (L) ohio (M) ontario (N) river (O) superior (P) york
[EX A]: indiana

[EX Q]: Context: Plants are mainly multicellular, predominantly photosynthetic eukaryotes of the kingdom Plantae., Bacteria (common noun bacteria, singular bacterium) constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a number of shapes, ranging from spheres to rods and spirals. Bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs, radioactive waste, and the deep portions of Earth's crust. Bacteria also live in symbiotic and parasitic relationships with plants and animals., A honey bee (or honeybee) is any bee member of the genus Apis, primarily distinguished by the production and storage of honey and the construction of perennial, colonial nests from wax. Currently, only seven species of honey bee are recognized, with a total of 44 subspecies, though historically, from six to eleven species have been recognized. The best known honey bee is the Western honey bee which has been domesticated for honey production and crop pollination. Honey bees represent only a small fraction of the roughly 20,000 known species of bees. Some other types of related bees produce and store honey, including the stingless honey bees, but only members of the genus "Apis" are true honey bees. The study of bees including honey bees is known as melittology., Animals are multicellular, eukaryotic organisms of the kingdom Animalia (also called Metazoa). The animal kingdom emerged as a basal clade within Apoikozoa as a sister of the choanoflagellates. Sponges are the most basal clade of animals. Animals are motile, meaning they can move spontaneously and independently at some point in their lives. Their body plan eventually becomes fixed as they develop, although some undergo a process of metamorphosis later in their lives. All animals are heterotrophs: they must ingest other organisms or their products for sustenance., Kakugo virus is a picorna - like virus most commonly found in the brains of worker bees . It is a subtype of the Deformed wing virus . The Kakugo ( Japanese for ' ready to attack ' ) virus , when resident in a bee 's brain , can contribute to aggressive behaviors such as are preeminent during a bee 's guard phase in their life cycle . Kakugo is the first virus to have been found to cause aggressive behavior , although because the virus was only recently discovered to have such effects , research into the matter is limited ., Deformed wing virus (DWV) is an RNA virus, one of 22 known viruses affecting honey bees. While most commonly infecting the honey bee, "Apis mellifera", it has also been documented in other bee species, like "Bombus terrestris", thus, indicating it may have a wider host specificity than previously anticipated. The virus was first isolated from a sample of symptomatic honeybees from Japan in the early 1980s and is currently distributed worldwide. Found also in pollen baskets and commercially reared bumblebees (Graystock et al 2013). Its main vector in "A. mellifera" is the Varroa mite. It is named after what is usually the most obvious deformity it induces in the development of a honeybee pupa, which is shrunken and deformed wings, but other developmental deformities are often present., A virus is a small infectious agent that replicates only inside the living cells of other organisms. Viruses can infect all types of life forms, from animals and plants to microorganisms, including bacteria and archaea., The Archaea (or or ) constitute a domain and kingdom of single-celled microorganisms. These microbes (archaea; singular archaeon) are prokaryotes, meaning that they have no cell nucleus or any other membrane-bound organelles in their cells., Bombus terrestris, the buff-tailed bumblebee or large earth bumblebee, is one of the most numerous bumblebee species in Europe. It is one of the main species used in greenhouse pollination, and so can be found in many countries and areas where it is not native, such as Tasmania. Moreover, it is a eusocial insect with an overlap of generations, a division of labor, and cooperative brood care. The queen is monandrous which means she mates with only one male. "B. terrestris" workers learn flower colors and forage efficiently., Varroa is a genus of parasitic mites associated with honey bees, placed in its own family, Varroidae. The genus was named for Marcus Terentius Varro, a Roman scholar and beekeeper. The condition of a honeybee colony being infested with "Varroa" mites is called varroosis (also, incorrectly, varroatosis)., Subject: kakugo virus, Relation: taxon_rank, Options: (A) domain (B) family (C) genus (D) kingdom (E) species
[EX A]: species

[EX Q]: Context: Cannabis is a genus of flowering plant that includes three species (and seven taxa) or subspecies, "sativa", "indica", and "ruderalis". The plant is indigenous to central Asia and the Indian subcontinent., Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it is in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms, with women more likely than men to present atypically. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat (including serious types), cardiogenic shock, or cardiac arrest.
Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake, among others. The mechanism of an MI often involves the complete blockage of a coronary artery caused by a rupture of an atherosclerotic plaque. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress, and extreme cold, among others. A number of tests are useful to help with diagnosis, including electrocardiograms (ECGs), blood tests, and coronary angiography. An ECG may confirm an ST elevation MI if ST elevation is present. Commonly used blood tests include troponin and less often creatine kinase MB.
Aspirin is an appropriate immediate treatment for a suspected MI. Nitroglycerin or opioids may be used to help with chest pain; however, they do not improve overall outcomes. Supplemental oxygen should be used in those with low oxygen levels or shortness of breath. In ST elevation MIs treatments which attempt to restore blood flow to the heart are typically recommended and include angioplasty, where the arteries are pushed open, or thrombolysis, where the blockage is removed using medications. People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use of angioplasty in those at high risk. In people with blockages of multiple coronary arteries and diabetes, bypass surgery (CABG) may be recommended rather than angioplasty. After an MI, lifestyle modifications, along with long term treatment with aspirin, beta blockers, and statins, are typically recommended.
Worldwide, about 8.6 million myocardial infarctions occurred in 2013. More than 3 million people had an ST elevation MI and more than 4 million had an NSTEMI. STEMIs occur about twice as often in men as women. About one million people have an MI each year in the United States. In the developed world the risk of death in those who have had an STEMI is about 10%. Rates of MI for a given age have decreased globally between 1990 and 2010., Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug. It is commonly snorted, inhaled, or injected into the veins. Mental effects may include loss of contact with reality, an intense feeling of happiness, or agitation. Physical symptoms may include a fast heart rate, sweating, and large pupils. High doses can result in very high blood pressure or body temperature. Effects begin within seconds to minutes of use and last between five and ninety minutes. Cocaine has a small number of accepted medical uses such as numbing and decreasing bleeding during nasal surgery.
Cocaine is addictive due to its effect on the reward pathway in the brain. After a short period of use, there is a high risk that dependence will occur. Its use also increases the risk of stroke, myocardial infarction, lung problems in those who smoke it, blood infections, and sudden cardiac death. Cocaine sold on the street is commonly mixed with local anesthetics, cornstarch, quinine, or sugar which can result in additional toxicity. Following repeated doses a person may have decreased ability to feel pleasure and be very physically tired.
Cocaine acts by inhibiting the reuptake of serotonin, norepinephrine, and dopamine. This results in greater concentrations of these three neurotransmitters in the brain. It can easily cross the bloodbrain barrier and may lead to the breakdown of the barrier. Cocaine is made from the leaves of the "coca" plant which are mostly grown in South America. In 2013, 419 kilograms were produced legally. It is estimated that the illegal market for cocaine is 100 to 500 billion USD each year. With further processing crack cocaine can be produced from cocaine.
After cannabis, cocaine is the most frequently used illegal drug globally. Between 14 and 21 million people use the drug each year. Use is highest in North America followed by Europe and South America. Between one and three percent of people in the developed world have used cocaine at some point in their life. In 2013 cocaine use directly resulted in 4,300 deaths, up from 2,400 in 1990. The leaves of the "coca" plant have been used by Peruvians since ancient times. Cocaine was first isolated from the leaves in 1860. Since 1961 the international Single Convention on Narcotic Drugs has required countries to make recreational use of cocaine a crime., The bloodbrain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain extracellular fluid in the central nervous system (CNS). The bloodbrain barrier is formed by brain endothelial cells, which are connected by tight junctions. The bloodbrain barrier allows the passage of water, some gases, and lipid-soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are crucial to neural function. Furthermore, it prevents the entry of lipophilic potential neurotoxins by way of an active transport mechanism mediated by P-glycoprotein. Astrocytes have been claimed to be necessary to create the bloodbrain barrier. A few regions in the brain, including the circumventricular organs, do not have a bloodbrain barrier., Stimulants (also referred to as psychostimulants) is an overarching term that covers many drugs including those that increase activity of the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects. Due to their rendering a characteristic "up" feeling, stimulants are also occasionally referred to as "uppers". Depressants or "downers", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be the functionally opposite drug class. Stimulants are widely used throughout the world as prescription medicines as well as without a prescription (either legally or illicitly) as performance-enhancing or recreational drugs. The most frequently prescribed stimulants as of 2013 were lisdexamfetamine, methylphenidate, and amphetamine. It is estimated that the percent of the population that has abused amphetamines, cocaine and MDMA combined is between .8% and 2.1%., Neurotransmitters, also known as chemical messengers, are endogenous chemicals that enable neurotransmission. They transmit signals across a chemical synapse, such as a neuromuscular junction, from one neuron (nerve cell) to another "target" neuron, muscle cell, or gland cell. Neurotransmitters are released from synaptic vesicles in synapses into the synaptic cleft, where they are received by receptors on the target cells. Many neurotransmitters are synthesized from simple and plentiful precursors such as amino acids, which are readily available from the diet and only require a small number of biosynthetic steps for conversion. Neurotransmitters play a major role in shaping everyday life and functions. Their exact numbers are unknown, but more than 100 chemical messengers have been uniquely identified., Stroke is when poor blood flow to the brain results in cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. They result in part of the brain not functioning properly. Signs and symptoms of a stroke may include an inability to move or feel on one side of the body, problems understanding or speaking, feeling like the world is spinning, or loss of vision to one side. Signs and symptoms often appear soon after the stroke has occurred. If symptoms last less than one or two hours it is known as a transient ischemic attack (TIA) or mini-stroke. A hemorrhagic stroke may also be associated with a severe headache. The symptoms of a stroke can be permanent. Long-term complications may include pneumonia or loss of bladder control.
The main risk factor for stroke is high blood pressure. Other risk factors include tobacco smoking, obesity, high blood cholesterol, diabetes mellitus, previous TIA, and atrial fibrillation. An ischemic stroke is typically caused by blockage of a blood vessel, though there are also less common causes. A hemorrhagic stroke is caused by either bleeding directly into the brain or into the space between the brain's membranes. Bleeding may occur due to a ruptured brain aneurysm. Diagnosis is typically with medical imaging such as a CT scan or magnetic resonance imaging (MRI) scan along with a physical exam. Other tests such as an electrocardiogram (ECG) and blood tests are done to determine risk factors and rule out other possible causes. Low blood sugar may cause similar symptoms.
Prevention includes decreasing risk factors, as well as possibly aspirin, statins, surgery to open up the arteries to the brain in those with problematic narrowing, and warfarin in those with atrial fibrillation. A stroke or TIA often requires emergency care. An ischemic stroke, if detected within three to four and half hours, may be treatable with a medication that can break down the clot. Aspirin should be used. Some hemorrhagic strokes benefit from surgery. Treatment to try recover lost function is called stroke rehabilitation and ideally takes place in a stroke unit; however, these are not available in much of the world.
In 2013 approximately 6.9 million people had an ischemic stroke and 3.4 million people had a hemorrhagic stroke. In 2010 there were about 33 million people who had previously had a stroke and were still alive. Between 1990 and 2010 the number of strokes which occurred each year decreased by approximately 10% in the developed world and increased by 10% in the developing world. In 2013, stroke was the second most frequent cause of death after coronary artery disease, accounting for 6.4 million deaths (12% of the total). About 3.3 million deaths resulted from ischemic stroke while 3.2 million deaths resulted from hemorrhagic stroke. About half of people who have had a stroke live less than one year. Overall, two thirds of strokes occurred in those over 65 years old., A pen (Latin: "penna", feather) is a writing implement used to apply ink to a surface, such as paper, for writing or drawing. Historically, reed pens, quill pens, and dip pens were used, with a nib dipped in ink. Ruling pens allow precise adjustment of line width, and still find a few specialized uses, but technical pens such as the Rapidograph are more commonly used. Modern types also include ballpoint, rollerball, fountain, and felt or ceramic tip pens., Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter. The name "noradrenaline," derived from Latin roots meaning "at/alongside the kidneys," is more commonly used in the United Kingdom; in the United States, "norepinephrine," derived from Greek roots having that same meaning, is usually preferred. "Norepinephrine" is also the international nonproprietary name given to the drug. Regardless of which name is used for the substance itself, parts of the body that produce or are affected by it are referred to as noradrenergic., In ordinary language, a crime is an unlawful act punishable by a state or other authority. The term "crime" does not, in modern criminal law, have any simple and universally accepted definition, though statutory definitions have been provided for certain purposes. The most popular view is that crime is a category created by law; in other words, something is a crime if declared as such by the relevant and applicable law. One proposed definition is that a crime or offence (or criminal offence) is an act harmful not only to some individual or individuals but also to a community, society or the state ("a public wrong"). Such acts are forbidden and punishable by law., Peru , officially the Republic of Peru, is a country in western South America. It is bordered in the north by Ecuador and Colombia, in the east by Brazil, in the southeast by Bolivia, in the south by Chile, and in the west by the Pacific Ocean. Peru is an extremely biodiverse country with habitats ranging from the arid plains of the Pacific coastal region in the west to the peaks of the Andes mountains vertically extending from the north to the southeast of the country to the tropical Amazon Basin rainforest in the east with the Amazon river., This is a list of countries ( and some territories ) by the annual prevalence of cocaine use as percentage of the population aged 15 -- 64 ( unless otherwise indicated ) . The primary sources of information are the World Drug Report 2014 ( WDR 2014 ) , and the World Drug Report 2006 ( WDR 2006 ) , published by the United Nations Office on Drugs and Crime ( UNODC ) . The indicator is the `` annual prevalence '' rate which is the percentage of the youth and adult population who have consumed the drug at least once in the past year ., The Single Convention on Narcotic Drugs of 1961 is an international treaty to prohibit production and supply of specific (nominally narcotic) drugs and of drugs with similar effects except under licence for specific purposes, such as medical treatment and research. As noted below, its major effects included updating the Paris Convention of 13 July 1931 to include the vast number of synthetic opioids invented in the intervening thirty years and a mechanism for more easily including new ones. From 1931 to 1961, most of the families of synthetic opioids had been developed, including drugs in whatever way related to methadone, pethidine, morphinans and dextromoramide and related drugs; research on fentanyls and piritramide was also nearing fruition at that point., Epinephrine, also known as adrenalin or adrenaline, is a hormone, neurotransmitter and medication. Epinephrine is normally produced by both the adrenal glands and certain neurons. It plays an important role in the fight-or-flight response by increasing blood flow to muscles, output of the heart, pupil dilation, and blood sugar. Epinephrine does this by its effects on alpha and beta receptors. It is found in many animals and some one cell organisms. Jokichi Takamine first isolated epinephrine in 1901. 
As a medication it is used to treat a number of conditions, including anaphylaxis, cardiac arrest, and superficial bleeding. Inhaled epinephrine may be used to improve the symptoms of croup. It may also be used for asthma when other treatments are not effective. It is given intravenously, by injection into a muscle, by inhalation, or by injection just under the skin. Common side effects include shakiness, anxiety, and sweating. A fast heart rate and high blood pressure may occur. Occasionally it may result in an abnormal heart rhythm. While the safety of its use during pregnancy and breastfeeding is unclear, the benefits to the mother must be taken into account., Peruvians are the citizens of the Republic of Peru or their descendants abroad. Peru is a multiethnic country formed by the combination of different groups over five centuries, so people in Peru usually treat their nationality as a citizenship rather than an ethnicity. Amerindians inhabited Peruvian territory for several millennia before Spanish Conquest in the 16th century; according to historian David N. Cook their population decreased from an estimated 59 million in the 1520s to around 600,000 in 1620 mainly because of infectious diseases. Spaniards and Africans arrived in large numbers under colonial rule, mixing widely with each other and with indigenous peoples. During the Republic, there has been a gradual immigration of European people (specially from Spain and Italy, and in a less extent from France, the Balkans, Great Britain and Germany). Japanese and Chinese arrived in large numbers at the end of nineteenth century., Crack cocaine, also known simply as crack, is a free base form of cocaine that can be smoked. It offers a short but intense high to smokers. The Manual of Adolescent Substance Abuse Treatment calls it the most "addictive" (effective) form of cocaine. Crack cocaine is commonly used as a recreational drug. Crack first saw widespread use in primarily impoverished inner city neighborhoods in New York, Los Angeles, and Miami in late 1984 and 1985; its rapid increase in use and availability is sometimes termed as the "crack epidemic"., Subject: list of countries by prevalence of cocaine use, Relation: is_a_list_of, Options: (A) ancient (B) century (C) country (D) drug (E) fountain (F) genus (G) language (H) line (I) name (J) people (K) person (L) plant (M) population (N) role (O) single (P) state (Q) street (R) system (S) term (T) year
[EX A]:
country