Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: In anaesthesia and in the intensive care unit, benzodiazepines have proven safe and effective agents for the induction and maintenance of sedation for a variety of therapeutic goals. However, in these contexts, or in benzodiazepine overdose, it is often desirable to be able to terminate or interrupt sedation without waiting for the effect of the benzodiazepine to become dissipated by normal metabolism and excretion. Flumazenil, a 1,4-imidazobenzodiazepine, is a highly effective, specific benzodiazepine antagonist which is indicated for use when the effect of a benzodiazepine must be attenuated or terminated at short notice. It acts by displacing other benzodiazepines from the receptor site by competitive inhibition. The onset of effect after intravenous administration occurs within 1 to 3 minutes. The optimal dosage is determined for each patient by a dose titration procedure and lies in the range 0.2 to 1.0mg in anaesthesiology, and 0.1 to 2.0mg in intensive care use. Despite its short elimination half-life of around 1 hour, after general anaesthesia or conscious to moderate sedation for short procedures, a single dose of flumazenil is usually sufficient to attain and maintain the desired level of consciousness. After intoxication with high benzodiazepine doses, the duration of effect of a single dose of flumazenil is not expected to exceed 1 hour. In such cases, the period of wakefulness can be prolonged as necessary by repeated low intravenous doses of flumazenil or by infusion (0.1 mg/hour). Flumazenil is well tolerated both systemically and locally. The only adverse events seen with greater frequency after flumazenil compared with placebo were nausea and/or vomiting after general anaesthesia, although the incidence of actual vomiting was not significantly different between the 2 groups. Since these effects were virtually absent in studies of intensive care patients and after sedation for short procedures, and were not seen in tolerability studies in healthy volunteers receiving intravenous bolus doses of up to 100mg, there may be a link between these symptoms and the other agents used in general anaesthesia, some of which have well-known emetic properties. Thus, flumazenil provides a safe and effective means of attenuating or reversing the CNS-depressant effects of benzodiazepines whenever indicated, e.g. following benzodiazepine-induced general anaesthesia, conscious sedation, or after benzodiazepine overdose, either alone or in combination with other agents.(ABSTRACT TRUNCATED AT 400 WORDS)

A: Which drug should be used as an antidote in benzodiazepine overdose?
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Q: Somewhere in harbourside Sydney, Australia, a family lives within a high-rise apartment building where the mother is preparing a meal and listening to the radio. Her fourteen year old daughter (Jenny Agutter) and six year old son (Luc Roeg) swim in the building's pool overlooking a view of the ocean while their father (John Meillon), deep in troubled thought, watches them from their balcony.One day, the father takes his children, still in their school uniforms, on a picnic into the Outback. He parks the car and reads while his daughter sets up a blanket with their lunch. Her brother plays nearby with his water gun and toy soldiers. Suddenly, and for reasons unclear to his children, the father announces it is time to go and brandishes a gun, firing several shots at them. The boy thinks it all to be a game but his sister understands the danger and shields her brother as they run from their mad father. She watches in horror as her father returns to the car and sets it on fire before seating himself within and putting a bullet into his head. Quickly, and keeping her brother's eyes averted, the girl retrieves their radio, a scarf, and what food she can carry before setting off into the wilderness with her brother.The siblings walk for hours under the hot sun, calmed by irrelevant radio broadcasts, and walking past a host of wild creatures. Come nightfall, they make a crude camp for themselves, much to the boy's delight. In the morning, the girl leads them up a rocky hillside where she hopes to find some bearings. However, she can see nothing but a broad spanse of wilderness. When they finish their lemonade, the girl opens a can of vegetables from which they drink the juice. Recalling an uncle's story of military training, the girl suggests they eat salt to retain water and surmises to her brother that they may spend some time in the desert. She remains stoic, but wary, while her brother is blissfully unaware of their situation, remaining entertained by the radio and his toys. Eventually, after becoming filthy and tired, they come upon a lone tree standing over a pool of water where parakeets flock and feast on fallen fruit. The boy puts on in his mouth and proclaims that it 'tastes lovely'. They wash in the water and the girl scolds her brother to take care of his clothes so they will last. When he asks if they are lost, the girl replies that they are not, trying to remain chipper. They sleep to the sounds of the radio as night animals stir around them.In the morning, the girl wakes to find that their water hole has dried up and the fruit has either been eaten or spoiled. The girl decides to remain where they are, hoping that the water will return. As they nap in the hot sun, the boy spots an aborigine youth (David Gulpilil) pursuing an animal for food. They make contact and the children attempt to communicate with the aborigine boy. However, he does not understand their language and merely stares at them with curiosity. The girl repeats their need for water but the word is incomprehensible to the aborigine. When her brother mimics drinking, the aborigine understands and shows them how to dig for water using a hollow tube to drink through. Assuming that he will lead them to civilization, the siblings accompany the aborigine, unaware that he is on a 'walkabout', a coming-of-age journey that every male aborigine youth must take alone in order to be initiated as an adult in his tribe.As they travel the Outback, the aborigine kills and harvests food for them, giving them all plenty to eat and drink. The move from the desert to greener pastures and forests where wildlife becomes plentiful. When the boy becomes sunburnt from going shirtless, the aborigine rubs pig fat on his back to alleviate the burn. While communication between them remains limited, the trio share food and play together, though cultural differences are evident; the boy attempts to share his toy soldiers with the aborigine, but he finds no use for them and tosses

A: What does the Aboriginal boy hunt down ?
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Q: Cap analysis of gene expression (CAGE) is a high-throughput method for transcriptome analysis that provides a single base-pair resolution map of transcription start sites (TSS) and their relative usage. Despite their high resolution and functional significance, published CAGE data are still underused in promoter analysis due to the absence of tools that enable its efficient manipulation and integration with other genome data types. Here we present CAGEr, an R implementation of novel methods for the analysis of differential TSS usage and promoter dynamics, integrated with CAGE data processing and promoterome mining into a first comprehensive CAGE toolbox on a common analysis platform. Crucially, we provide collections of TSSs derived from most published CAGE datasets, as well as direct access to FANTOM5 resource of TSSs for numerous human and mouse cell/tissue types from within R, greatly increasing the accessibility of precise context-specific TSS data for integrative analyses. The CAGEr package is freely available from Bioconductor at [Link]

A:
Which tool is used for promoterome mining using CAGE data?
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