Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor-like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues. To date, more than 130 different mutations in the NOTCH3 gene have been reported in CADASIL patients, of which 95% are missense point mutations. Many polymorphisms have also been identified in the NOTCH3 coding sequence, some of them leading to amino acid substitutions. The aim of the present study was to analyze the NOTCH3 gene in a large group of patients affected by leukoencephalopathy and to investigate the presence of genetic variants. The molecular analysis revealed several nucleotide alterations. In particular, we identified 20 different mutations, 22 polymorphisms, and 8 genetic variants of unknown pathological significance never reported previously. We hope that this NOTCH3 gene mutational analysis, performed in such a significant number of unrelated and related patients affected by leukoencephalopathy, will help in molecular screening for the NOTCH3 gene, thus contributing to enlargement of the NOTCH3 gene variation database.

Answer: Which amino acid residue appears mutated in most of the cases reported with  cadasil syndrome?


Question: The Battle of Adwa (also known as Adowa, or sometimes by the Italian name Adua) was fought on 1 March 1896 between the Ethiopian Empire and the Kingdom of Italy near the town of Adwa, Ethiopia, in Tigray.

Answer: The point in time of Battle of Adwa was when?


Question: In February 2009, James L. Jones, then-chairman of the Atlantic Council, stepped down in order to serve as President Obama's new National Security Advisor and was succeeded by Senator Chuck Hagel.

Answer:
Who led Atlantic Council?