Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a small vessel disease of the brain caused by mutations in the NOTCH3 gene. CADASIL progresses, in some cases, to subcortical dementia with a particular cognitive impairment. Different diseases in the dementia spectrum share a central cholinergic and sensorimotor plasticity alteration. We aimed to study different intracortical circuits and sensorimotor plasticity in CADASIL patients using transcranial magnetic stimulation protocols, and to determine whether these characteristics correlated with the results of clinical neuropsychological evaluation. Ten CADASIL patients and 10 healthy subjects were included in the study. All subjects underwent a transcranial magnetic stimulation study examining different intracortical circuits. Sensorimotor plasticity was also assessed using a paired associative stimulation and extensive neuropsychological tests. CADASIL patients showed a lack of intracortical facilitation, short latency afferent inhibition and sensorimotor plasticity when compared with control subjects. CADASIL patients also showed an altered neuropsychological profile. Correlation between sensorimotor plasticity and neuropsychological alterations was observed in CADASIL patients. These results suggest that acetylcholine and glutamate could be involved in the dementia process in CADASIL and that abnormal sensorimotor plasticity correlates with the neuropsychological profile in CADASIL patients.
[EX A]: Which gene is involved in CADASIL?

[EX Q]: Siltuximab, a chimeric monoclonal antibody with high affinity and specificity for interleukin-6, has been shown to enhance anti-multiple myeloma activity of bortezomib and corticosteroid in vitro. We evaluated the safety, pharmacokinetics, immunogenicity, and antitumor effect of siltuximab in combination with bortezomib and dexamethasone in Japanese patients with relapsed or refractory multiple myeloma. This open-label, phase 1, dose-escalating study used two doses of siltuximab: 5.5 and 11.0 mg/kg (administered on day 1 of each 21-day cycle). In total, nine patients were treated. The most common grade 3/4 adverse events, lymphopenia (89 %) and thrombocytopenia (44 %), occurred in patients receiving both doses of siltuximab; however, no dose-limiting toxicities (DLTs) were observed. Following intravenous administration of siltuximab at 5.5 and 11.0 mg/kg, the maximum serum concentration and the area under the curve from 0 to 21 days and from 0 to infinity increased in an approximately dose-proportional manner. Mean half-life, total systemic clearance, and volume of distribution were similar at doses of 5.5 and 11.0 mg/kg. Across both doses, six of the nine patients had complete or partial response (22 and 44 %, respectively). In conclusion, as no DLT was observed, the recommended dose for this combination is 11.0 mg/kg once every 3 weeks. The study is registered at [Link] as NCT01309412.
[EX A]: Which interleukin is blocked by Siltuximab?

[EX Q]: For Fall 2018, Berkeleys acceptance rate for freshman was 15.1%. Total enrollment was 41,910 - 30,574 undergraduate and 11,336 graduate students - with women accounting for 52.7% of undergraduates and 46.2% of graduate and professional students. Of enrolled freshman, nearly 54% were women and approximately 60% self-identified as persons of color. Enrolled freshman had an average weighted secondary school GPA of 4.45 (unweighted GPA of 3.92) and had an average SAT score of 1435 (average ACT score of 32). The interquartile range for SAT scores was 1340-1530, with 660-750 for reading/writing and 670-750 for math. Berkeleys enrollment of National Merit Scholarship Program was third in the nation until 2002, when participation in the National Merit program was discontinued. For 2016-17, Berkeley ranked fifth in enrollment of recipients of the National Merit Scholarship Program (136 scholars). 33% of admitted students receive federal Pell grants.
[EX A]:
In Fall of 2018 were there more women or men enrolled as freshman?