Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: P&O European Ferries (formerly Townsend Thoresen), a division of P&O Ferries, was a ferry company which operated in the English Channel from 1987 after the Herald of Free Enterprise disaster, when Townsend Thoresen was renamed P&O European Ferries, until 1999 when the Portsmouth Operations became P&O Portsmouth and the Dover Operation where merged with Stena Line AB to make P&O Stena Line.

Output: What is the ending year of P&O European Ferries?


Input: Consider Input: The 2008 Tour of Qatar was held from 27 January to 1 February 2008 in Qatar.

Output: On what date did 2008 Tour of Qatar end?


Input: Consider Input: Rosiglitazone, a synthetic peroxisome proliferator-activated receptor- (PPAR) agonist, prevents cell death after cerebral ischemia in animal models, but the underlying mechanism has not been clarified. In this study, we examined how rosiglitazone protects neurons against ischemia. Mice treated with rosiglitazone were subjected to 60 minutes of focal ischemia followed by reperfusion. Rosiglitazone reduced infarct volume after ischemia and reperfusion. We show that this neuroprotective effect was reversed with a PPAR antagonist. Western blot analysis showed a significant increase in expression of phosphorylated stress-activated protein kinases (c-Jun N-terminal kinase (JNK) and p38) in ischemic brain tissue. Rosiglitazone blocked this increase. Furthermore, we observed that rosiglitazone increased expression of the dual-specificity phosphatase 8 (DUSP8) protein and messenger RNA in ischemic brain tissue. Dual-specificity phosphatase 8 is a mitogen-activated protein kinase phosphatase that can dephosphorylate JNK and p38. Another key finding of the present study was that knockdown of DUSP8 in primary cultured cortical neurons that were subjected to oxygen-glucose deprivation diminished rosiglitazone's effect on downregulation of JNK phosphorylation. Thus, rosiglitazone's neuroprotective effect after ischemia is mediated by blocking JNK phosphorylation induced by ischemia via DUSP8 upregulation.


Output: Which protein is affected by dusp8 activation?