Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
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Question: The 80-string koto (or hachijugen) was an invention of Japanese composer Michio Miyagi which appeared In 1923.

Answer: By whom was 80-string koto discovered?


Question: Parkinson's disease is the most common neurodegenerative movement disorder. The motor impairments of Parkinson's disease are caused by the loss of dopaminergic neurons in the substantia nigra and associated with the appearance of fibrillar aggregates of -synuclein (-syn) called Lewy bodies. Approximately 90% of -syn deposited in Lewy bodies is phosphorylated at serine 129 (Ser129). In contrast, only 4% or less of total -syn is phosphorylated at this residue in the normal brain. This suggests that the accumulation of Ser129-phosphorylated -syn leads to the formation of Lewy bodies and dopaminergic neurodegeneration in Parkinson's disease. Our laboratory and others have performed experiments using in vivo models of Parkinson's disease to elucidate the role of increased Ser129 phosphorylation in -syn neurotoxicity. However, there has been a lack of consistency among these models. In this review, we summarize the main findings regarding the relationship between Ser129 phosphorylation and -syn neurotoxicity, and examine the differences among models. We further discuss the role of Ser129 phosphorylation in -syn aggregation and the future directions to test the potential of Ser129 phosphorylation as a therapeutic target for slowing the progression of Parkinson's disease.

Answer: Which residue of alpha-synuclein was found to be phosphorylated in Lewy bodies?


Question: Cleopatra and Antony staged both ''Donations'' to donate lands dominated by Rome and Parthia to Cleopatra's children: the 11-year-old Caesarion (fathered by Julius Caesar) and the 4 year old twins Alexander Helios and Cleopatra Selene II (fathered by Marc Antony) initially in 36 BC, and in 34 BC including the 2 year old Ptolemy Philadelphus.

Answer:
Who is Caesarion's sister?