Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Input: Consider Input: In the 1950s, a family that owned a farm near Beulah, Michigan kept a bull chained to an elm . The bull paced around the tree, dragging the heavy iron chain, which led to a groove in the bark . The groove deepened over the years. Though for whatever reason, it did not kill the tree. After some years, the family took their bull away. They cut the chain, leaving the loop around the tree and one link hanging down. Then one year, agricultural disaster struck Michigan in the form of Dutch Elm Disease. All of the elms lining the road leading to the farm became infected and died. Everyone thought that the old elm would be the next. The farm owners considered doing the safe thing: pulling it out and cutting it up into firewood before it died. But they simply could not bring themselves to do it. It was as if the old tree had become a family friend. So they decided to let nature take its course. Amazingly, the tree did not die. Nobody could understand why it was the only elm still standing in the county! Plant experts from Michigan State University came out to observe the tree. They observed the scar left by the iron chain, now almost completely covered by bark. The experts decided that it was the chain that saved the elm's life. They reasoned that the tree must have absorbed so much iron from the chain that it became immune to the virus. It's said that what doesn't kill you will make you stronger. Or, as Earnest Hemingway put it, "Life breaks us all, but afterwards, many of us are strongest at the broken places."

Output: What actually saved the elm?


Input: Consider Input: With an ageing population and improving cancer therapies, the two most common benign and malignant bone diseases, osteoporosis and bone metastases, will continue to affect an increasing number of patients. Our expanding knowledge of the molecular processes underlying these conditions has resulted in novel bone targets that are currently being explored in clinical trials. Clearly, the approval of denosumab, a monoclonal antibody directed against RANKL, has just marked the beginning of a new era for bone therapy with several additional new therapies lining up for clinical approval in the coming years. Potential agents targeting the osteoclast include cathepsin K, currently in phase 3 trials, and src inhibitors. Amongst anabolic agents, inhibitors of the Wnt-inhibitor sclerostin and dickkopf-1 are promising in clinical trials. Here, we will provide a comprehensive overview of the most promising agents currently explored for the treatment of bone diseases.

Output: To the ligand of which receptors does Denosumab (Prolia) bind?


Input: Consider Input: It was the last KH-2 Corona' satellite, which was based on an Agena-B. The launch of Discoverer 28 occurred at 00:01 UTC on 4 August 1961.


Output: When was the launch date of Discoverer 28?