TASK DEFINITION: In this task, you are given a sentence and a verb from the sentence. Your task is to generate a set of wh-questions starting with who, what, when, where, why, how, how much. The generated questions must contain the verb and the answers to these questions are phrases in the input sentence. The answer to the questions is associated with a specific semantic role. The answer to these questions is associated with a specific semantic role. The questions must use pronouns instead of direct nouns that could be used to refer to various roles present in the sentence. Construct a question in such a way that (i) it is unambiguous, (ii) its answer is unique (iii) its answer is a continuous text span from the paragraph.
PROBLEM: Sentence: When BrdU is integrated into DNA , it is supposed that the bromine deforms the minor groove so that Hoechst dyes can not reach their optimal binding site . 
 Verb: integrated

SOLUTION: what will  be integrated  into something?

PROBLEM: Sentence: When BrdU is integrated into DNA , it is supposed that the bromine deforms the minor groove so that Hoechst dyes can not reach their optimal binding site . 
 Verb: binding

SOLUTION: where is something binding?

PROBLEM: Sentence: A type modifier is used to make a pointer or reference . 
 Verb: used

SOLUTION:
what is  used  to do something?