In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Example Input: Paragraph: Background: Infrared thermography (IRT) is used to screen febrile passengers at international airports, but it suffers from low sensitivity. This study explored the application of a combined visible and thermal image processing approach that uses a CMOS camera equipped with IRT to remotely sense multiple vital signs and screen patients with suspected infectious diseases. Methods: An IRT system that produced visible and thermal images was used for image acquisition. The subjects' respiration rates were measured by monitoring temperature changes around the nasal areas on thermal images; facial skin temperatures were measured simultaneously. Facial blood circulation causes tiny color changes in visible facial images that enable the determination of the heart rate. A logistic regression discriminant function predicted the likelihood of infection within 10 s, based on the measured vital signs. Sixteen patients with an influenza-like illness and 22 control subjects participated in a clinical test at a clinic in Fukushima, Japan. Results: The vital-sign-based IRT screening system had a sensitivity of 87.5% and a negative predictive value of 91.7%; these values are higher than those of conventional fever-based screening approaches. Conclusions: Multiple vital-sign-based screening efficiently detected patients with suspected infectious diseases. It offers a promising alternative to conventional fever-based screening. 
 Title: Remote sensing of multiple vital signs using a CMOS camera-equipped infrared thermography system and its clinical application in rapidly screening patients with suspected infectious diseases
Example Output: True

Example Input: Paragraph: Background. Animal models suggest that influenza infection favors nasopharyngeal acquisition of pneumococci. We assessed this relationship with influenza and other respiratory viruses in young children. Methods. A case-control study was nested within a prospective cohort study of acute respiratory illness (ARI) in Andean children <3 years of age (RESPIRA-PERU study). Weekly household visits were made to identify ARI and obtain nasal swabs for viral detection using real-time reverse-transcription polymerase chain reaction. Monthly nasopharyngeal (NP) samples were obtained to assess pneumococcal colonization. We determined whether specific respiratory viral ARI episodes occurring within the interval between NP samples increased the risk of NP acquisition of new pneumococcal serotypes. Results. A total of 729 children contributed 2128 episodes of observation, including 681 pneumococcal acquisition episodes (new serotype, not detected in prior sample), 1029 nonacquisition episodes (no colonization or persistent colonization with the same serotype as the prior sample), and 418 indeterminate episodes. The risk of pneumococcal acquisition increased following influenza-ARI (adjusted odds ratio [AOR], 2.19; 95% confidence interval [CI], 1.02-4.69) and parainfluenza-ARI (AOR, 1.86; 95% CI, 1.15-3.01), when compared with episodes without ARI. Other viral infections (respiratory syncytial virus, human metapneumovirus, human rhinovirus, and adenovirus) were not associated with acquisition. Conclusions. Influenza and parainfluenza ARIs appeared to facilitate pneumococcal acquisition among young children. As acquisition increases the risk of pneumococcal diseases, these observations are pivotal in our attempts to prevent pneumococcal disease. 
 Title: The Role of Influenza and Parainfluenza Infections in Nasopharyngeal Pneumococcal Acquisition Among Young Children
Example Output: False

Example Input: Paragraph: Porcine circovirus type 2 (PCV2) is the essential infectious agent responsible for causing porcine circovirus-associated diseases in pigs. To date, eleven RNAs and five viral proteins of PCV2 have been detected. Here, we identified a novel viral gene within the PCV2 genome, termed ORF5, that exists at both the transcriptional and translational level during productive infection of PCV2 in porcine alveolar macrophages 3D4/2 (PAMs). Northern blot analysis was used to demonstrate that the ORF5 gene measures 180 bp in length and overlaps completely with ORF1 when read in the same direction. Site-directed mutagenesis was used to show that the ORF5 protein is not essential for PCV2 replication. To investigate the biological functions of the novel protein, we constructed a recombinant eukaryotic expression plasmid capable of expressing PCV2 ORF5. The results show that the GFP-tagged PCV2 ORF5 protein localizes to the endoplasmic reticulum (ER), is degraded via the proteasome, inhibits PAM growth and prolongs the S-phase of the cell cycle. Further studies show that the GFP-tagged PCV2 ORF5 protein induces ER stress and activates NF-κB, which was further confirmed by a significant upregulation in IL-6, IL-8 and COX-2 expression. In addition, five cellular proteins (GPNMB, CYP1A1, YWHAB, ZNF511 and SRSF3) were found to interact with ORF5 via yeast two-hybrid assay. These findings provide novel information on the identification and functional analysis of the PCV2 ORF5 protein and are likely to be of benefit in elucidating the molecular mechanisms of PCV2 pathogenicity. However, additional experiments are needed to validate the expression and function of the ORF5 protein during PCV2 infection in vitro before any definitive conclusion can be drawn. piglets and is clinically characterized by fever, unthriftiness, respiratory distress, enlarged lymph nodes, and occasional jaundice and diarrhea [7] [8] . Many other conditions, including congenital tremors (CT), porcine dermatitis and nephropathy syndrome (PDNS), porcine respiratory disease complex (PRDC), reproduction disorders and fetal myocarditis, are also closely related to PCV2 infection [9] [10] [11] [12] [13] [14] . PCV2 infection leads to the development of microscopic lesions mainly dominated by lymphoid depletion and histiocytic infiltration in lymphoid tissues [9, [15] [16] [17] . Mortality rates may vary from 15 to 20% and can be significantly higher in the presence of co-infection with either porcine reproductive and respiratory syndrome virus (PRRSV) or mycoplasma hyopneumoniae [7] [8] 18] . PCV2 infection has thus far caused huge economic losses to the swine industry worldwide. The PCV2 genome is a single-stranded, ambisense, closed circular DNA containing between 1,766 and 1,768 nucleotides [19] [20] . Although the nucleotide homology within individual isolates of either PCV1 or PCV2 is over 90%, the homology between PCV1 and PCV2 as serotypes is only 68% to 76% [19, 21] . This diversity may be responsible for the differences in pathogenicity or virulence observed for these serotypes. The virus was predicted to possess 11 overlapping open reading frames (ORFs) [19], of which four have been characterized in detail in replicating PCV2. On the viral strand, there is the ORF1 (nucleotides 51-995) gene, which encodes the Rep and Rep' proteins essential for PCV2 replication [22]. On the complementary strand, there are the ORF2 (nucleotides 1735-1034), ORF3 (nucleotides 671-357) and ORF4 (nucleotides 565-386) genes, which encode the capsid protein [23], apoptotic protein [21] and controversial anti-apoptotic protein, respectively [24-25]. Previous transcriptional analysis conducted during productive PCV2 infection of porcine kidney cells measured nine unique PCV2-specific RNA transcripts (designated-CR, Rep, Rep 0 , Rep3a, Rep3b, Rep3c, NS515, NS672, and NS0) [26]; however, only CR, Rep and Rep 0 transcripts were proven capable of translation into functional proteins [22, [26] [27] . In contrast, ORF3 and ORF4 transcripts, which are not included in the above nine RNAs, were subsequently confirmed to play important roles in the pathogenesis of PCV2; ORF3-deficient PCV2 is attenuated in its natural host [28] , and ORF4-deficient PCV2 induces a higher viral load and more severe microscopic lesions in the spleen during early stages of infection in mice [24] . Collectively, these research findings indicate that PCV2 pathogenesis is both complicated and multigenic and that the individual viral proteins encoded by ORF2, ORF3 or ORF4 are insufficient in determining pathogenicity. Previous computational analysis has revealed that the PCV2 genome contains at least seven ORFs with the potential to encode proteins > 5 kDa [29] ; to date, four have been identified. However, it has not yet been determined whether the three additional predicted proteins exist or whether there are still other viral proteins encoded by PCV2 that control its pathogenicity. Sequence alignment analysis of PCV2 isolates from varying geographic regions suggested that the putative ORF5 gene (proposed to exist by Hamel et al) might not encode a functional protein, as translation of the protein was found to terminate after only seven amino acids in some Chinese PCV2 strains [19, 30] . However, several groups have aligned the genomic sequences of various PCV2 isolates and found a region of extremely high identity (over 95%) at the amino acid level, suggesting that PCV2 encodes a novel protein, although different names for this possible protein have been used in the literature (Gen Bank accession no. O92288, Q77GS3, Q77S04, etc). This new putative viral gene (designated ORF5 in this study), which is entirely different from that predicted by Hamel et al in 1998 [19], completely overlaps the ORF1 gene and is read in the same direction. The ORF5 gene is approximately 180 bp (spanning nucleotides 553-732) and encodes a polypeptide that is predicted to be of 6.5 kDa in molecular weight, whereas the corresponding region of PCV1 does not appear to produce a peptide. As PCV1 isolates are naturally nonpathogenic [31] [32] and PCV2 isolates are pathogenic, this putative polypeptide may be important for the pathogenesis of PCV2. Presently, no Functional Analysis of GFP-Fused Putative PCV2 ORF5 Protein PLOS ONE | 
 Title: Identification of Putative ORF5 Protein of Porcine Circovirus Type 2 and Functional Analysis of GFP-Fused ORF5 Protein
Example Output:
False