Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

MicroRNAs (miRNAs) constitute a large family of noncoding RNAs that function as guide molecules in diverse gene silencing pathways. Current efforts are focused on the regulatory function of miRNAs, while little is known about how these unusual genes themselves are regulated. Here we present the first direct evidence that miRNA genes are transcribed by RNA polymerase II (pol II). The primary miRNA transcripts (pri-miRNAs) contain cap structures as well as poly(A) tails, which are the unique properties of class II gene transcripts. The treatment of human cells with alpha-amanitin decreased the level of pri-miRNAs at a concentration that selectively inhibits pol II activity. Furthermore, chromatin immunoprecipitation analyses show that pol II is physically associated with a miRNA promoter. We also describe, for the first time, the detailed structure of a miRNA gene by determining the promoter and the terminator of mir-23a approximately 27a approximately 24-2. These data indicate that pol II is the main, if not the only, RNA polymerase for miRNA gene transcription. Our study offers a basis for understanding the structure and regulation of miRNA genes.
Which polymerase transcribes pri-miRNAs?

Yana De Leeuw (born 6 September 1990) is a Belgian female former volleyball player, playing as a setter.
Which sex or gender can Yana De Leeuw be described as?

The Toyota MR2 is a two-seat, mid-engined, rear-wheel-drive sports car manufactured in Japan and marketed globally by Toyota from 1984-2007 over three generations:

What year did Toyota MR2 start?