In this task, you're given a paragraph and title from the research paper. Your task is to classify whether the given title is suitable or not for the research paper based on the given paragraph. Return "True" if title is proper according to paragraph else "False".

Q: Paragraph: Background: The goal of this study was to evaluate whether a live attenuated poliovirus vaccine (OPV) has clinically relevant interfering effect with non-polio infections causing otitis media in young children. Methods: Open trial in which the intervention group (64 children) received OPV at the age of 2, 3, 6 and 12 months. The control group (250 children) received IPV (inactivated polio vaccine) at the age of 6 and 12 months. Clinical symptoms were recorded by a questionnaire at the age of 3, 6, 12, 18 and 24 months. Results: Otitis media episodes were less frequent in the OPV than in the control group. A significant difference was seen at the age of 6-18 months (IRR = 0.76 [95% CI 0.59-0.94], P = 0.011) and was particularly clear among children, who attended daycare (IRR 0.37 [95% CI 0.19-0.71], P = 0.003). Conclusions: OPV provides some protection against otitis media. This effect may be mediated by viral interference with non-polio viruses. 
 Title: Viral interference induced by live attenuated virus vaccine (OPV) can prevent otitis media

A: False
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Q: Paragraph: Coronaviruses (CoVs) are positive-sense single-stranded RNA viruses and contain the largest known RNA genomes, ranging from 27 to 32 kilobases in length. CoVs are capable of transspecies movement as evidenced by the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) epidemic in 2002-2003 [1,2]. Additionally, the emergence of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in 2012 demonstrates that CoVs continue to cause severe and lethal human disease [3] . Exactly how CoVs maintain the integrity of their large genomes while generating the population diversity required for emergence and adaptation has been a major question in RNA virology. The discovery of 39-to-59 exoribonuclease (ExoN) activity within CoV nonstructural protein 14 (nsp14-ExoN), which is critical for CoV high-fidelity replication, has challenged the long-held paradigm that RNA viruses cannot proofread and raises the possibility of an entirely new model for how RNA viruses regulate replication fidelity. We will summarize: 1) the data supporting proofreading during CoV replication; 2) the possibility of a multi-protein fidelity complex, using E. coli DNA polymerase III as a conceptual framework; and 3) the promise of genetic and therapeutic interference with fidelity regulation as an approach for attenuation and treatment of CoVs. 
 Title: Coronaviruses as DNA Wannabes: A New Model for the Regulation of RNA Virus Replication Fidelity

A: True
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Q: Paragraph: It is well known that piglets congenitally infected with porcine reproductive and respiratory syndrome virus (PRRSV) can be viremic at birth, and that preweaning mortality due to secondary infections often increases during acute outbreaks of PRRS. Therefore, an immunosuppressive effect of in utero infection has been suggested. The aim of the present study was to characterise the changes of leukocyte populations in piglets surviving in utero infection with PRRSV. A total of 27 liveborn uninfected control piglets and 22 piglets infected transplacentally with a Danish strain of PRRSV were included. At 2 and 4 weeks of age, 21 of 22 (96%) and 7 of 14 (50%) examined infected piglets were still viremic, whereas PRRSV could not be detected in the six infected piglets examined at 6 weeks of age. Flow cytometry analysis was used to determine the phenotypic composition of leukocytes in peripheral blood and bronchoalveolar lavage fluid (BALF) of 2-, 4-and 6-week-old infected piglets and age-matched uninfected controls. The key observation in the present study is that high levels of CD8 þ cells constitute a dominant feature in peripheral blood and BALF of piglets surviving in utero infection with PRRSV. In BALF, the average high level of CD8 þ cells in 2-week-old infected piglets (33:4 AE 12:6%) was followed by a decline to 7:3 AE 3:0 and 11:1 AE 3:0% at 4 and 6 weeks of age. BALF of control piglets contained 1:6 AE 0:9, 2:3 AE 1:8 and 1:9 AE 0:5% CD8 þ cells, only. In peripheral blood, however, the average number of CD8 þ cells remained at high levels in the infected piglets throughout the post-natal experimental period (2:8 AE 1:9, 2:9 AE 1:8 and 3:2 AE 1:7 Â 10 6 CD8 þ cells/ml at 2, 4 and 6 weeks, respectively). In the controls, the average levels of CD8 þ cells were 0:9 AE 0:2, 1:9 AE 1:7 and 1:6 AE 0:5 Â 10 6 /ml, respectively. Furthermore, the numbers of CD2 þ , CD4 þ CD8 þ and SLA-classII þ cells, respectively, in peripheral blood, together with the levels of CD2 þ and CD3 þ cells in BALF were increased in the infected piglets infected in utero compared to the uninfected controls. Veterinary Immunology and Immunopathology 93 (2003) 135-151 Abbreviations: SLA, swine leukocyte antigen; FSC, forward light scattering; SSC, side light scattering; BALF, bronchoalveolar lavage fluid; PPAM, porcine pulmonary alveolar macrophages; WBC, white blood cells; CD, cluster of differentiation The kinetic analyses carried out in the present study reflect that in utero infection with PRRSV modulates immune cell populations in peripheral blood and BALF of surviving piglets. The observed changes are characterised by high levels of CD8 þ cells supporting an important role of these cells in PRRSV infection. The present results, however, do not support the existence of post-natal immunosuppression following in utero infection with PRRSV. # 
 Title: In utero infection with porcine reproductive and respiratory syndrome virus modulates leukocyte subpopulations in peripheral blood and bronchoalveolar fluid of surviving piglets

A:
False
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