Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Input: Consider Input: Context: The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein tau. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds tau with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the tau-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10(-9) M MAP2c and 10(-8) M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and tau might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease. 
 Question: Which ApoE isoform is associated with atherosclerosis and Alzheimer's disease?

Output: apoe4 isoform


Input: Consider Input: Context: Rick Riker (Drake Bell) is an unpopular student at Empire High with his only friend Trey (Kevin Hart), living with his uncle Albert (Leslie Nielsen) and Aunt Lucielle (Marion Ross). His crush Jill Johnson (Sara Paxton), who hardly notices him, is dating Rick's bully Lance Landers (Ryan Hansen). Rick and Trey are then shown to be on a school trip to an animal research lab. In the lab Rick meets Lou Landers (Christopher McDonald) who coughs up blood because he is terminally ill. Dr. Strom, the head researcher at the lab, then shows his seven mutated dragonflies, though there are only six there because one has escaped which then bites Rick, and causes his neck to swell.The scene then goes to Rick's house where his Aunt Lucille and Uncle Albert are talking on the couch when Rick comes in. He is very sick, and throws up in a fish tank because of his illness and goes up to his room. Albert and Lucille believe Rick is acting strange, so Albert proceeds to talk to Rick. Rick then passes out from the bite.He wakes up the next morning, with a strange video sent to him from a man wanting to speak to him, later adding Rick as a friend on Facebook. Meanwhile, Lou Landers gets into a scientific accident, transforming into the Hourglass who feeds on human life. At a science fair, with a comically rude and mean-spirited Stephen Hawking who gets physically hurt throughout the film, Rick gets into mishaps, such as becoming stuck to water fountains. He then realizes he has superpowers such as the ability to walk on walls, has incredible strength, but cannot fly. He tests his strength in an alleyway, then decides to test how he can walk up walls. He climbs up and begins to break dance, then has a lie-down on the wall and a cat walks up the wall beside him. He then sees an old woman about to be hit by a truck in the road, and just as she is about to get hit he pushes her out of the way and the truck collides with him stopping it.After his heroic feat he is congratulated by passers-by, but as they are congratulating him he looks to his right and sees he has accidentally pushed the woman into a woodchipper and the dog she was holding the lead of up is slowly getting pulled up into the machine as well. Trey offers to become his sidekick, but Rick resigns. His Uncle and he have a brief fight, which reminds Rick when he was younger and rich with his parents who die in a spoof of Batman Begins. His father urges him to invest of all his money in, not Google, but Enron.Rick later watches the girl of his dreams, Jill, who leaves with Lance in his car. Rick wants a car, and he sets out to get money from the bank. He fails though, with no credit or payment.After his uncle is quickly injured, Rick is met by Xavier (Tracy Morgan) at his school for mutants ala X-Men. Rick is told to make a costume, which he does (and later improves), and he becomes known as the Dragonfly. He quickly becomes a sensation, until his fight with the Hourglass, who ends up cutting him with little hourglass blades. The Hourglass then escapes.Jill is then seen walking in an alleyway and is attacked by thugs, but the Dragonfly saves her. The two then try to kiss, but encounter difficulties as Dragonfly is hanging upside down. They eventually kiss for the first time, and Jill thanks him.The scene then goes to a Thanksgiving dinner at Rick's house. During Thanksgiving Landers visits the family (everyone is unaware he is Hourglass). He nearly catches Rick dressed as the Dragonfly, but later manages to figure out his secret identity.Just as Rick and Jill are about to fall in love, the Hourglass comes in and murders Aunt Lucille. After a comical funeral, Rick decides to throw in the towel as a superhero.Trey and Uncle Albert find Rick after the funeral 
 Question: Who plays Rick riker?

Output: drake bell


Input: Consider Input: Context: Jonathan Shale (Berenger) is a mercenary and a Vietnam veteran who returns home to Miami after a botched covert operation in Cuba in which three men from his platoon were killed. He surprises his girlfriend, Jane Hetzko (Diane Venora) at her apartment and is warmly welcomed. On the outside, Jane is a schoolteacher at inner-city Columbus High School, an institution with a considerable gang problem. She is particularly disliked by Juan Lacas (Anthony), leader of the KOD ("Kings of Destruction") gang. While jogging one morning, Jane is attacked and has her leg broken. Jane and Shale believe this to be related to the KOD, which prompts the latter to go undercover as an Ivy League-educated, government-affiliated substitute teacher for his girlfriend's class. Shale arrives at Columbus High School and is, at first, taken back by the lowly conditions. He is unable to control his class of poorly-educated students on the first day, but decides to use his street-smarts and military tactics to gain the upper hand. Soon enough, he is able to take command of the students by displaying his combat self-defence techniques when students attack him. He is warned not to use such methods by Principal Claude Rolle (Hudson), but gains the respect of his students when he bonds with them over the similarities between his early gang and Vietnam War experiences and their involvement in petty crime and street gangs. During this time, he befriends fellow schoolteacher Darrell Sherman (Plummer) and also crosses paths with Lacas, one of his students. Suspicious of odd conditions within the high school, Shale sets up surveillance cameras throughout the building. He discovers that Lacas orchestrated the attack on Jane. He also discovers that Lacas is secretly working with Rolle to distribute cocaine around Miami for a major narcotics ring. Shale and his team raid a drug deal, using the stolen money to buy music and sports equipment in the form of a "school donation." While Sherman initially denies Shale's discovery, Sherman and a female student inadvertently witness the drugs being loaded into one of the school buses later that day. Sherman tells the student to warn Shale and Hetzko, and sacrifices himself by creating a distraction. Rolle, who at this point is aware of Shale's interference orders a "car accident" for Shale, and sends Lacas after Hetzko. With the help of another student, Lacas is killed and Shale saves Hetzko, learning the full story from the female witness. Shale and his team garrison the school grounds to enter combat against the remaining K.O.D. members, a rival mercenary company led by Janus, and Rolle himself. Ultimately, Shale and Joey Six end up as the sole survivors of the battle, walking away from the school grounds discussing future operations as substitute teachers. 
 Question: Shale is an undercover principal at a gang-run high school in what city?


Output: miami