Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

[EX Q]: Processing of filtrate in the proximal tubule helps maintain the ph level in body fluid.
[EX A]: Processing of filtrate in the proximal tubule helps maintain what level in body fluid?

[EX Q]: Multiple genes mutations is usually necessary to develop cancer.
[EX A]: What is usually necessary to develop cancer?

[EX Q]: An endocrine disease usually involves the secretion of too much or not enough hormone by endocrine gland.
[EX A]:
An endocrine disease usually involves the secretion of too much or not enough hormone by which gland?