TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: Something strange was unbelievable. Take Robert for example. After the terrible car accident, his whole world had been completely dark and quiet for almost ten years. The loss of sight and hearing made him try many times to put end to his life. His family especially his wife did their best to tend and comfort him. By and by he finally regained the courage to live on. On a hot summer afternoon he was taking a walk with a stick near his house when a thunderstorm started suddenly. He stood under a large tree in order not to get himself wet. Unfortunately he was struck down to the ground by a lightning. The witnesses thought him dead but he woke up some 20 minutes later lying face down in muddy water below the tree. He felt that he was trembling badly, but when he opened his eyes ,he didn't dare to believe that he saw a plough( )lying near the wall. When Mrs Edwards came running up to him, she shouted their neighbours for help. And he saw her and heard her voice for the first time in nearly ten years. The news of Robert's regaining his sight and hearing quickly spread in his area. And many doctors came to prove the truth of the news. Most of them said that he gained sight and hearing again obviously from the knock of lightning; none of them could give convincing reasons, however. The only reasonable explanation given by one doctor was that, since Edwards lost his sight and hearing as a result of sudden shock in a terrible accident, perhaps the only way for them to regain was by another sudden shock.

SOLUTION: What did Edwards see first after being struck down by a lightning?

PROBLEM: The SP790 study (ClinicalTrials.gov, NCT00136045) showed benefits of rotigotine over placebo in improving symptom severity of restless legs syndrome (RLS), also known as Willis-Ekbom disease, on the International Restless Legs Syndrome Study Group rating scale (IRLS), Clinical Global Impression item 1 (CGI-1), RLS 6-item questionnaire (RLS-6), and the RLS-quality of life questionnaire (RLS-QoL) in patients with moderate to severe idiopathic RLS. To provide clinical context for the IRLS and to guide the choice of assessment scales for RLS studies, our post hoc analysis of SP790 data evaluated associations between the IRLS and the CGI-1, IRLS and RLS-6, and the IRLS and RLS-QoL. Scale associations were analyzed at baseline and at the end of maintenance (EoM) using data from the safety set (rotigotine and placebo groups combined [n=458]). Changes from baseline to EoM in IRLS score vs comparator scale scores also were analyzed. There was a trend towards increasing IRLS severity category with increasing CGI-1, RLS-6, and RLS-QoL score. Pearson product moment correlation coefficients showed correlations between IRLS and comparator scale scores at baseline and EoM as well as correlations for change from baseline to EoM. Correlations between the IRLS and comparator scales were substantial. These data indicate that the IRLS is clinically meaningful. The IRLS and CGI-1 are generally sufficient to evaluate the overall severity and impact of RLS symptoms in clinical trials.

SOLUTION: Willis-Ekbom disease is also known as?

PROBLEM: In a previous study, we reported that two kaempferol glycosides isolated from Laurus nobilis L., kaempferol-3-O-alpha-L-(2'',4''-di-E-p-coumaroyl)-rhamnoside (C2) and kaempferol-3-O-alpha-L-(2''-E-p-coumaroyl-4''-Z-p-coumaroyl)-rhamnoside (C3), showed strong antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. Thereafter we found that these compounds greatly reduced the minimum inhibitory concentrations (MICs) of some fluoroquinolones in MRSA. In other words, C2 and C3 greatly potentiated anti-MRSA activity of fluoroquinolones. The effect of C2 and C3 with fluoroquinolones was found to be synergistic. The potentiation activity was observed with hydrophilic fluoroquinolones, such as norfloxacin and ciprofloxacin, but not with hydrophobic quinolones. We also found that norfloxacin reduced MICs of C2 and C3. The effect was synergistic. Possible mechanism of the synergistic effect was discussed.

SOLUTION:
What is MRSA?