Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.

Q: The settlements with the patient assistance charities Good Days and Patient Access Network Foundation were the first with foundations linked to an industry-wide probe that has resulted in $840 million in settlements with drugmakers. Both foundations provide assistance to patients seeking to pay out-of-pocket costs for medications. Good Days agreed to pay $2 million while PAN Foundation agreed to pay $4 million. Neither admitted wrongdoing. Good Days in a statement said the settlement will allow it to concentrate on providing help to people in need of life-saving medications. PAN said the settlement involved “legacy matters” rather than its current operations. Drug companies are prohibited from subsidizing co-payments for patients enrolled in the government’s Medicare healthcare program for those aged 65 and older. Companies may donate to non-profits providing co-pay assistance as long as they are independent. But the government has alleged that various drugmakers have used charities like Good Days and PAN as means to improperly pay the co-pay obligations of Medicare patients using their drugs, in violation of the Anti-Kickback Statute. The department said Good Days, previously known as the Chronic Disease Fund, from 2010 to 2014 conspired with companies including Novartis AG, Astellas and Questcor, now owned by Mallinckrodt Plc, to pay kickbacks to Medicare patients using their drugs. Those drugs included H.P. Acthar Gel, an expensive treatment for a rare infant seizure disorder and multiple sclerosis that is subject of a related lawsuit by the government against Mallinckrodt over Questcor’s donations to the charity. The Justice Department said Questcor from 2010 to 2014 used the charity as a conduit to improperly subsidize patients’ copays, allowing it to keep raising prices for Acthar, whose price increased from $50 per vial in 2001 to $32,200 in 2014. Mallinckrodt declined to comment. It has said it believed its actions were lawful. PAN similarly permitted Bayer AG, Astellas, Dendreon Pharmaceuticals and Amgen Inc to use it as a conduit to pay patients kickbacks, according to the government’s allegations. Astellas and Amgen in April agreed to pay $100 million and $24.75 million, respectively, to resolve related claims. Dendreon said it takes compliance seriously. Novartis declined to comment. The other companies’ representatives did not respond to requests for comment.

A: Two charities to pay $6 million to resolve U.S. pharma kickback probe.
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Q: While governments in at least 20 other states obtained more than 30 million doses of the drug through donations from the federal reserve or private companies, Oklahoma and Utah instead bought them from private pharmaceutical companies. Top officials in both states chalked up the decisions to “the fog of war.”  Oklahoma Gov. Kevin Stitt on Tuesday defended the state’s $2 million purchase, saying the drug was showing some promise. His health secretary attributed buying the 1.2 million hydroxychloroquine pills to something that happens in the “fog of war.”  Utah Gov. Gary Herbert at first defended the state’s $800,000 purchase of 20,000 packets of hydroxychloroquine compounded with zinc, but has since ordered an investigation of a no-bid contract with a local company that had been promoting the drugs. Herbert, a Republican, also canceled an additional plan to spend $8 million more to buy 200,000 additional treatments from the same company. A left-leaning nonprofit group in Utah filed a price gouging complaint Tuesday with state regulators, arguing the $40 per pack drug was grossly overpriced. Oklahoma’s attorney general requested an investigative audit on Tuesday of its Department of Health over spending and warned the agency about retaliating against employees who report wrongful government activities under the state’s Whistleblower Act. A spokesman for Attorney General Mike Hunter declined to comment on whether the request was related to the $2 million spent on the drug. Doctors can already prescribe the malaria drug to patients with COVID-19, a practice known as off-label prescribing, and many do. But the U.S. Food and Drug Administration on Friday warned doctors against prescribing hydroxychloroquine for treating the coronavirus outside of hospitals or research settings because of reports of serious side effects, including irregular heart rhythms and death among patients. Preliminary results from a recent study done on coronavirus patients at U.S. veterans hospitals showed no benefit, casting more doubt on the drug’s efficacy during the pandemic. Those were the latest admonitions against the drug that Trump has regularly promoted in public appearances, touting its potential despite his own health advisors telling him it is unproven. Oklahoma acquired 1.2 million pills, or about 100,000 doses, on April 4 from FFF Enterprises, a California-based medical supply wholesaler, according to the Oklahoma State Department of Health. Oklahoma state Rep. Melissa Provenzano, a Democrat from Tulsa, said the state’s purchase shows that Gov. Stitt’s actions don’t follow his claim that he relies on data to drive his decisions. “Two million dollars is a lot of money to waste, especially when we have unemployment claims approved yet going unpaid, health care professionals without proper protective equipment, and diagnosed cases and deaths continuing to rise,” Provenzano said. Stitt, a first-term Republican, said hydroxychloroquine was showing some promise as a treatment in early March, and he didn’t want Oklahoma to miss out on an opportunity to acquire it. “Now there’s some evidence the chloroquine may not be as effective, but I was being proactive to try and protect Oklahomans,” Stitt said Tuesday when asked about the purchase. “That’s always going to be my first instinct, to get the equipment and things we need that I’m seeing in the future would help Oklahomans.” Oklahoma’s Secretary of Health Jerome Loughridge said several physicians, including some in Oklahoma, were previously optimistic about the drug’s promise in treating COVID-19. He added that the drug is also useful for treating lupus and some other auto-immune diseases, so the state’s supply “will not have gone to waste.” “When we were battling sort of the fog of war at that point, we certainly acquired it on the potential that it would have utility,” Loughridge said. Jeff Burton, a former adjutant general of the Utah National Guard chosen to lead the state health department’s coronavirus task force, offered a similar explanation for why the state made its purchase. He said the state never received the pills and is trying to get its money back. “I chalk it up to fog of war,” Burton told the state’s pharmacy board. “There was a lot going on. It’s easy to judge it from (an) easy chair.. . . Since then we’ve decided that was not a wise purchase.”  Doctors in Oklahoma have been using the drug to treat patients with COVID-19, often in conjunction with a second drug, azithromiocin, but the results “just are not that promising,” said Dr. Douglas Drevets, chief of infectious diseases at University of Oklahoma Medicine. FFF Enterprises said it’s the company’s policy not to comment on transactions with customers. Utah gave a local company called Meds in Motion the $800,000 contract without taking bids from other companies under emergency procurement rules, said Christopher Hughes, director of Utah’s division of purchasing. State officials haven’t explained why they didn’t seek to get the drugs for free. The Federal Emergency Management Agency said Saturday it has sent out 28.6 million tablets of hydroxychloroquine sulfate free of cost to states around the country. Several states including New York, Connecticut and Texas received donations of the medication from a private company based in New Jersey called Amneal Pharmaceutical, according to information compiled by The Associated Press. Utah taxpayers deserve to know what happened to allow a purchase that seems like a company taking advantage of the early, chaotic days of the pandemic, said Chase Thomas, executive director of the group called Alliance for a Better Utah that submitted the price gouging complaint. The complaint alleges Utah paid at least double the common price for the medication. “Whether they were buying drugs we didn’t need or paying too much for it when they could have gotten them for free, there just needed to be a lot more thought going into this,” Thomas said. Meds in Motion didn’t answer an email seeking comment about the allegations. Herbert declined to provide an update Tuesday about the investigation of the purchase. He said Friday the state’s legal counsel would aim to find out what, how and why it happened. He said he believed state officials acted in good faith as they scrambled to slow the spread of coronavirus, but acknowledged a mistake may have been made. “I have some questions about how it came about,” Herbert said Friday. “Bottom line is, we’re not purchasing any more of this drug.”  ___ McCombs and Whitehurst reported from Salt Lake City.

A: Oklahoma, Utah face scrutiny over malaria drug purchases.
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Q: The innovative brain shuttle technology, which has so far been tested in mice, can cross the blood-brain barrier that has been a key obstacle for researchers working on neurological drugs because it acts as a seal against large molecules such as antibodies. Alzheimer’s is a fatal brain-wasting disease that affects 44 million people worldwide, with the number set to triple by 2050, campaign group Alzheimer’s Disease International says. Although there is still no treatment that can effectively modify the disease or slow its progression, a number of companies - including Roche, Eli Lilly, Merck & Co and Johnson & Johnson - are pursuing a variety of approaches to get to the root cause. It is proving an uphill battle. Over the past 15 years more than 100 experimental Alzheimer’s drugs have failed in tests. Industry analysts believe that the prize for a truly effective drug could be a market worth $10 billion in annual sales. Roche’s new technology works by hijacking a natural transport mechanism called receptor-mediated transcytosis, which is normally used by the body to transfer proteins inside the brain. “We have basically designed this module, called shuttle, that binds to this transport mechanism and shuttles a cargo inside the brain,” Luca Santarelli, Roche’s head of neuroscience, ophthalmology and rare diseases, said in a telephone interview. Results of a study published in the journal Neuron on Wednesday found the technology helped to increase the concentration of antibodies in the brains of mice, reducing the amount of amyloid plaque, which is a hallmark of Alzheimer’s. Roche tested a precursor of its experimental Alzheimer’s drug gantenerumab in the pre-clinical trials. The amount of antibody that penetrated the brain increased more than fiftyfold. Santarelli said that the brain shuttle technology is not limited to the memory-robbing disease and could be applied to other neurodegenerative disorders such as Huntington’s disease. The drugmaker is in the process of evaluating which therapeutic targets and diseases to prioritize. Roche has struck a deal with U.S. biotech firm Isis to develop treatments for Huntington’s and aims to engineer a shuttle to increase penetration of drugs into the brain. It is also working on a program with Irish company Prothena in Parkinson’s disease. Santarelli said that all projects are still in pre-clinical testing and the company needs to undertake a few more steps before it can begin clinical trials. Turning to Roche’s Alzheimer’s pipeline, he said that its Phase III trial of gantenerumab in patients who have yet to develop dementia is on track, with results expected in the first half of 2016. Roche has two other drugs in clinical testing, including crenezumab, which has been chosen for a U.S. government-backed trial in a group of Colombians with a genetic mutation that leads to Alzheimer’s in their forties.

A:
Roche 'brain shuttle' technology offers Alzheimer's hope.
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