In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

[Q]: Question: A 55-year-old woman with adrenal insufficiency has been prescribed corticosteroid treatment. Which of the following instructions would you provide in relation to this treatment? 
 Options:  <1> Take the drug first thing in the morning. <2> Take the drug before bedtime. <3> Exclude foods rich in calcium and vitamin D from the diet. <4> Eat a diet low in calories and protein. <5> Monitor the decrease in blood pressure.
[A]: 1


[Q]: Question: The proteasome: 
 Options:  <1> It is formed by 21 homologous subunits organized in 3 rings. <2> It is a protein complex that catalyzes the hydrolysis of ubiquitinated proteins. <3> It is found only in animal eukaryotic cells. <4> Digest acylated proteins. <5> It is activated by a drug, bertezomil, in therapy for multiple myeloma.
[A]: 2


[Q]: Question: Sodium metal reacts violently with water because Na: 
 Options:  <1> Oxidize the water to oxygen, and the reaction is very exothermic. <2> It reduces the water to hydrogen, and the reaction is very exothermic. <3> Oxidizes the water to oxygen, and when a gas is generated, the entropy increases enormously. <4> It reduces the water to hydrogen, and the reaction is very endothermic. <5> It combines with water giving rise to an explosive hydride.
[A]:
2