Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

Input: Consider Input: Context: Fluorescence in situ hybridization (FISH) technique has been successfully used to detect the BCR-ABL gene fusion in chronic myeloid leukemia (CML) with the classic form of the Philadelphia chromosome (Ph). We applied FISH to study three CML patients showing variant Ph chromosome (either complex or simple type). The results demonstrate that the use of a yeast artificial chromosome (YAC)-derived probe (D107F9) and a cosmid probe (cos-abl 8), specific for BCR and ABL genes respectively, allows also the detection of the BCR-ABL fusion in CML patients with variant Ph. 
 Question: Which gene fusion is the result of the "philadelphia translocation" or the "philadelphia chromosome" mutation?

Output: the bcr/abl gene fusion


Input: Consider Input: Context: Scores of people queued up to use a cash machine after it started giving out double the money requested. The cash machine, outside a Sainsbury's store in Barham Road, Hull, attracted a big crowd of people hoping to take advantage of the fault, on Tuesday night. Police officers were eventually sent in to guard the machine and prevent anymore money from being withdrawn. The fault is thought to have affected cash machines at supermarkets across the city. It is not yet known whether the customers will have to repay the cash or how much money was taken out. A spokeswoman for Humberside Police said, "Officers were sent to the cash machine to prevent anyone else from withdrawing anymore money. We have also tried to make contact with the owners of the machine." The spokeswoman said those who benefited from the fault could be traced and could face theft charges, but investigations would only take place if the operator made a complaint. The cash machine is owned by a company called Payzone, a spokesman later confirmed. He said the fault was due to the machine being filled with notes of the wrong denomination . An investigation is underway into the incident and the machine had been taken out of service, he added. The Payzone spokesman said, "The transit company which is contracted to service this ATM has filled it up with the wrong denomination of notes, meaning it is paying out double what it should have. " He could not say how much money had been taken out of the machine, or whether it would have to be paid back. It was understood that a number of cash machines in Hull owned by other companies had also been affected by this problem, he added. 
 Question: Who caused the cash machine not to work properly?

Output: the transit company.


Input: Consider Input: Context: Nucleotide excision repair (NER) mechanism is the major pathway responsible for the removal of a large variety of bulky lesions from the genome. Two different NER subpathways have been identified, i.e. the transcription-coupled and the global genome repair pathways. For DNA-damage induced by ultraviolet light both transcription-coupled repair and global genome repair are essential to confer resistance to cytotoxic effects. To gain further insight into the contribution of NER subpathways in the repair of bulky lesions and in their prevention of biological effects we measured the rate of repair of dG-C8-AF in active and inactive genes in normal human cells, XP-C cells (only transcription-coupled repair) and XP-A cells (completely NER-deficient) exposed to NA-AAF. XP-C cells are only slightly more sensitive to NA-AAF than normal cells and, like normal cells, they are able to recover RNA synthesis repressed by the treatment. In contrast, XP-A cells are sensitive to NA-AAF and unable to recover from RNA synthesis inhibition. Repair of dG-C8-AF in the active ADA gene proceeds in a biphasic way and without strand specificity, with a subclass of lesions quickly repaired during the first 8 h after treatment. Repair in the inactive 754 gene occurs more slowly than in the ADA gene. In XP-C cells, repair of dG-C8-AF in the ADA gene is confined to the transcribed strand and occurs at about half the rate of repair seen in normal cells. Repair in the inactive 754 gene in XP-C cells is virtually absent. Consistent with these results we found that repair replication in XP-C is drastically reduced when compared with normal cells and abolished by alpha-amanitin indicating that the repair in XP-C cells is mediated by transcription-coupled repair only. Our data suggest that dG-C8-AF is a target for transcription-coupled repair and that this repair pathway is the main pathway or recovery of RNA synthesis inhibition conferring resistance to cytotoxic effects of NA-AAF. In spite of this, repair of dG-C8-AF in active genes in normal cells by transcription-coupled repair and global genome repair is not additive, but dominated by global genome repair. This indicates that the subset of lesions which are capable of stalling RNA polymerase II, and are, therefore, a substrate for TCR, are also the lesions which are very efficiently recognized by the global genome repair system. 
 Question: Which gene strand is targeted by transcription-coupled repair (TCR)?


Output: the transcribed strand