Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Q: Destructive thyrotoxicosis appeared 4-6 months after starting IFN-alpha, followed by Graves' hyperthyroidism within 8 to 11 months.

A: adverse drug event
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Q: A manual pumping test is commonly used to verify the patency of a ventriculoperitoneal (V-P) shunt.

A: non-adverse drug event
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Q: It is used alone or in combination with other lipid-lowering agents in the treatment of various forms of hypercholesterolemia.

A:
non-adverse drug event
****