Given scientific fact as input, generate the question from this fact such that it can be answered from the input.

Example Input: The ileocecal valve, a sphincter, is usually in a constricted state, but when motility in the ileum increases, this sphincter relaxes, allowing food residue to enter the first portion of large intestine.
Example Output: The ileocecal valve, a sphincter, is usually in a constricted state, but when motility in the ileum increases, this sphincter relaxes, allowing food residue to enter the first portion of what?

Example Input: Temperature and ph level are important in the activity of an enzyme.
Example Output: Temperature and what other environmental factor are important in the activity of an enzyme?

Example Input: Pangaea began breaking apart 250 million years ago.
Example Output:
How many millions of years ago did pangaea begin breaking apart?