Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: Yana De Leeuw (born 6 September 1990) is a Belgian female former volleyball player, playing as a setter.
[EX A]: Which sex or gender can Yana De Leeuw be described as?

[EX Q]: Somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene are present in lung adenocarcinomas that respond to the EGFR inhibitors gefitinib and erlotinib. Two types of mutations account for approximately 90% of mutated cases: short in-frame deletions in exon 19 and a specific point mutation in exon 21 at codon 858 (L858R). Screening for these mutations has been based mainly on direct sequencing. We report here the development and validation of polymerase chain reaction-based assays for these two predominant types of EGFR mutations. The assay for exon 19 mutations is based on length analysis of fluorescently labeled polymerase chain reaction products, and the assay for the exon 21 L858R mutation is based on a new Sau96I restriction site created by this mutation. Using serial dilutions of DNAs from lung cancer cell lines harboring either exon 19 or 21 mutations, we detected these mutations in the presence of up to approximately 90% normal DNA. In a test set of 39 lung cancer samples, direct sequencing detected mutations in 25 cases whereas our assays were positive in 29 cases, including 4 cases in which mutations were not apparent by sequencing. These assays offer higher sensitivity and ease of scoring and eliminate the need for sequencing, providing a robust and accessible approach to the rapid identification of most lung cancer patients likely to respond to EGFR inhibitors.
[EX A]: Mutations in which gene determine response to both erlotinib and gefitinib?

[EX Q]: "People are ruder today because they are rushed and more 'time poor' than ever before, " says Patsy Rowe, " Manners have fallen off the radar . " Due to our strong attraction to electronic equipment it is a wonder more people don't wake up each morning and greet the singing birds with a complaint about the noise. Here are some examples of rudeness. Some people prefer to do almost everything over the internet. To them, dealing with an actual human is like an evolutionary step backward. It feels very slow because humans don, t work at 4G speeds. When you have dinner with friends, you will often notice someone paying more attention to his mobile phone. We have programmed ourselves to think that every new message brings life-changing news, so taking calls and checking our texts are more important than talking to the people we are with. What is worse, some people even tend to send anonymous rude messages by email. However, rudeness is never acceptable, Don, t assume it is OK to be rude if the person you, re in touch with won, t recognize you. If you have something awful to say, have the courage to face the person and say it, write a letter or email and sign it, or forget it. Upsetting people with unsigned messages is cruel and disgusting. We shouldn't blame technology for our shortcomings. Technology is here to help us, but we should not allow it to take over our lives. An important step is acknowledging our shortcomings. People spend a lot of time pointing out bad manners but it would be even more help if we'd publicly acknowledge good manners when we see them.
[EX A]:
The author thinks sending unsigned awful messages is