Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Jo was the first to wake in the gray dawn of Christmas morning. No stockings hung at the fireplace, and for a moment she felt as much disappointed as she did long ago, when her little sock fell down because it was crammed so full of goodies. Then she remembered her mother's promise and, slipping her hand under her pillow, drew out a little red-covered book. She knew it very well, for it was that beautiful old story of the best life ever lived, and Jo felt that it was a true guidebook for any pilgrim going on a long journey. She woke Meg with a "Merry Christmas," and asked her to see what was under her pillow. A green-covered book appeared, with the same picture inside, and a few words written by their mother, which made their one present very precious in their eyes. Presently Beth and Amy woke to find their little books also, one grey-color1ed, the other blue, and all sat looking at and talking about them, while the east grew rosy with the coming day. "Girls," said Meg seriously, "Mother wants us to read and love and mind these books, and we must begin at once. I shall keep my book on the table here and read a little every morning as soon as I wake, for I know it will do me good and help me through the day." Then she opened her new book and began to read. Jo put her arm round her and, leaning cheek to cheek, read also, with the quiet expression so seldom seen on her restless face. Much impressed by the pretty books and her sisters' example, the other two started reading too. And then the rooms were very still while the pages were softly turned, and the winter sunshine crept in to touch the bright heads and serious faces with a Christmas greeting. "Where is Mother?" asked Meg, as she and Jo ran down to thank her for their gifts, half an hour later. "Your ma went straight off to see what was needed in a poor woman's home." Replied Hannah, who had lived with the family since Meg was born, and was considered by them all more as a friend than a servant. "She will be back soon, I think, so fry your cakes, and have everything ready," said Meg, looking over the presents which were collected in a basket and kept under the sofa, ready to be produced at the proper time." "There's Mother. Hide the basket, quick!" cried Jo, as a door slammed and steps sounded in the hall. The girls rushed to the table, eager for breakfast. "Merry Christmas, Mummy! Thank you for our books. We read some, and mean to every day," they all cried happily together. "Merry Christmas, little daughters! I'm glad you began at once, and hope you will keep on. But I want to say one word before we sit down. Not far away from here lies a poor woman with a little newborn baby. Six children are huddled into one bed to keep from freezing, for they have no fire. There is nothing to eat over there, and the oldest boy came to tell me they were suffering hunger and cold. My girls, will you give them your breakfast as a Christmas present?" They were all unusually hungry, having waited nearly an hour, and for a minute no one spoke, only a minute, for Jo exclaimed excitedly, "I'm so glad you came before we began!" Then the four girls put the cream, the muffins and the buckwheat bread into a big basket. "I thought you'd do it," said Mrs. March, smiling as if satisfied." You shall all go and help me, and when we come back we will have bread and milk for breakfast, and make it up at dinner time." They were soon ready, and the procession set out. A poor, bare, miserable room it was, with broken windows, no fire, ragged bedclothes
Who got the green-covered book with a few words written by Mother as a Christmas gift?

Isova is a ruined Frankish monastery in the Peloponnese, Greece, which was built after the Fourth Crusade and inhabited by Cistercian monks.
To which religious order did Isova belong?

Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. The objective of this phase 2 study was to evaluate the efficacy and safety of R788, an oral inhibitor of Syk, in patients with active rheumatoid arthritis despite methotrexate therapy. We enrolled 457 patients who had active rheumatoid arthritis despite long-term methotrexate therapy in a 6-month, double-blind, placebo-controlled trial. The primary outcome was the American College of Rheumatology (ACR) 20 response (which indicates at least a 20% reduction in the number of both tender and swollen joints and improvement in at least three of five other criteria) at month 6. R788, at a dose of 100 mg twice daily and at a dose of 150 mg once daily, was significantly superior to placebo at month 6 (ACR 20 response rates of 67% and 57%, respectively, vs. 35%; P<0.001 for the comparison of both doses with placebo). It was also significantly superior with respect to ACR 50, which indicates at least a 50% improvement (43% and 32% vs. 19%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.007 for the comparison of the 150-mg dose with placebo) and ACR 70 (28% and 14% vs. 10%; P<0.001 for the comparison of the 100-mg dose with placebo, P=0.34 for the comparison of the 150-mg dose with placebo). A clinically significant effect was noted by the end of the first week of treatment. Adverse effects included diarrhea (in 19% of subjects taking the 100-mg dose of R788 vs. 3% of those taking placebo), upper respiratory infections (14% vs. 7%), and neutropenia (6% vs. 1%). R788 was associated with an increase in systolic blood pressure of approximately 3 mm Hg between baseline and month 1, as compared with a decrease of 2 mm Hg with placebo; 23% of the patients taking R788 vs. 7% of the patients receiving placebo required the initiation of or a change in antihypertensive therapy. In this phase 2 study, a Syk inhibitor reduced disease activity in patients with rheumatoid arthritis; adverse events included diarrhea, hypertension, and neutropenia. Additional studies will be needed to further assess the safety and efficacy of Syk-inhibition therapy in patients with rheumatoid arthritis. (Funded by Rigel; ClinicalTrials.gov number, NCT00665925.)

Which enzyme is inhibited by a drug fostamatinib?