Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event.

Q: CONCLUSIONS: The results of our study suggest that the pharmacokinetics of parent ifosfamide may not be substantially altered in patients with renal failure.

A: non-adverse drug event
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Q: Hypersensitivity reactions involving the kidneys can occur with any of the penicillin groups.

A: non-adverse drug event
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Q: Catatonia associated with disulfiram therapy.

A:
adverse drug event
****