You are given a background paragraph that describes one or more causal or qualitative relationships such as a relationship in economics or a scientific law and a story that makes use of the concepts or the relationship described in the provided paragraph. You need to come up with a question about the story that requires an understanding of the relationship described in the background paragraph. The generated question should not be answerable without both the background and story. Write a question about the story that requires a relationship in the background paragraph to answer. Check whether your question requires both the background paragraph and the story to answer. If your question can be answered by only one of these, try to rewrite your question so that it requires both. Note that "flipping" a word in the question can give rise to a new question where the answer will be different from the original question. Often, "flipping" a word gives rise to flipping the direction of the relationship, for example, from "increase" to "decrease."
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Question: Background Paragraph: The primary role of red blood cells in the circulatory system is to transport oxygen to the tissues. The actual carrier of oxygen molecules is the protein hemoglobin, which binds to the oxygen and moves it throughout the body, releasing it in areas where the concentration of dissolved oxygen is low. A certain mutation in the gene for hemoglobin causes a slight change in the structure of this crucial protein, resulting in a disease called sickle-cell anemia. For people with this mutation, the hemoglobin produced by their red blood cells has a tendency to clump together, distorting the shape of the red blood cells and giving rise to the crescent-shaped cells seen above. By understanding the changes in structure that are the underlying cause of this disease, we have developed various ways to treat and manage this illness. 
Story: Doctor Jones studied two teams of workers. Team one had healthy people with normal red blood cell levels, but team two had people with sickle-cell anemia. the differences in health parameters were amazing and obvious.

Answer: Which team didn't have people with crescent shaped cells in their blood?


Question: Background Paragraph: Unfortunately, the layer of good ozone is being destroyed by air pollution. The chief culprits are chlorine and bromine gases. They are released in aerosol sprays, coolants, and other products. Loss of ozone has created an ozone hole over Antarctica. Ozone depletion results in higher levels of UV radiation reaching Earth. In humans, this increases skin cancers and eye cataracts. It also disturbs the nitrogen cycle, kills plankton, and disrupts ocean food webs. The total loss of the ozone layer would be devastating to most life. It’s rate of loss has slowed with restrictions on pollutants, but it is still at risk. 
Story: The researches studied the atmosphere in Antarctica, and close to Greenland. They found out there's an ozone hole over Antarctica.

Answer: Which landmass didn't have its atmosphere destroyed by aerosol sprays?


Question: Background Paragraph: As a cell grows, its volume increases more quickly than its surface area. If a cell was to get very large, the small surface area would not allow enough nutrients to enter the cell quickly enough for the cell’s needs. This idea is explained in Figure below . However, large cells have a way of dealing with some size challenges. Big cells, such as some white blood cells, often grow more nuclei so that they can supply enough proteins and RNA for the cell’s requirements. Large, metabolically active cells often have lots of cell protrusions, resulting in many folds throughout the membrane. These folds increase the surface area available for transport of materials into or out of the cell. Such cell types are found lining your small intestine, where they absorb nutrients from your food through protrusions called microvilli . 
Story: Mike is studying for his biology exam. He found that all body cells are not equal in size - some are large and some are small. He labeled the large cells as class A cells. Then he labeled the small cells as class B cells. He is now prepared to find the differences between them.

Answer:
Which cell might have less number nuclei, class A or class B?