Given a passage with a question and an answer to that question, classify if the answer actually answers the question into 'yes' or 'no'. Output 'yes' if the answer answers the question and output 'no' if the answer does not answer the question.

Q: Question: Does monocyte chemoattractant protein-1 or macrophage inflammatory protein-1alpha deficiency affect angiotensin II-induced intimal hyperplasia in carotid artery ligation model?
Answer: These results indicate that MCP-1 or MIP-1alpha may not be essential in mediating the proliferative effects of Ang II, a major pathological changes in intimal hyperplasia in the carotid artery ligation model.

A: no
****
Q: Question: Are immunologic marker paths for seroconversion : single determinations of immunoglobulin A and beta 2-microglobulin adequate to estimate time of HIV infection . Multicohort Analysis Project Workshop . Part II?
Answer: Further study of how serum IgA reflects HIV infection and careful clinical and statistical assessment of reduced beta 2M from 5 or 6 years after HIV infection are needed. The dependence of marker paths on mode of HIV transmission suggests that sexual transmission may have implications for HIV disease progression. The feasibility of using serum IgA and beta 2M, evaluable in single stored blood samples, to estimate time of HIV infection has been set back by our results.

A: no
****
Q: Question: Does repeated ingestion of grapefruit juice alter clozapine 's steady-state plasma levels , effectiveness , and tolerability?
Answer: Consumption of regular-strength grapefruit juice, 250 mL b.i.d., for 14 days did not significantly impact clozapine metabolism, clinical efficacy, or tolerability. One reason is that enzymes other than CYP3A4 also mediate clozapine disposition. Also, grapefruit juice inhibits CYP3A4 in the gut, but not in the liver. The preliminary results also suggest that clozapine is unlikely to be a P-glycoprotein substrate. Further rigorous studies are necessary to reconfirm these findings.

A:
no
****