Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Example Input: CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor-like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues. To date, more than 130 different mutations in the NOTCH3 gene have been reported in CADASIL patients, of which 95% are missense point mutations. Many polymorphisms have also been identified in the NOTCH3 coding sequence, some of them leading to amino acid substitutions. The aim of the present study was to analyze the NOTCH3 gene in a large group of patients affected by leukoencephalopathy and to investigate the presence of genetic variants. The molecular analysis revealed several nucleotide alterations. In particular, we identified 20 different mutations, 22 polymorphisms, and 8 genetic variants of unknown pathological significance never reported previously. We hope that this NOTCH3 gene mutational analysis, performed in such a significant number of unrelated and related patients affected by leukoencephalopathy, will help in molecular screening for the NOTCH3 gene, thus contributing to enlargement of the NOTCH3 gene variation database.
Example Output: Which amino acid residue appears mutated in most of the cases reported with  cadasil syndrome?

Example Input: Aava Whistler Hotel Star Ratings: Location: Whistler Rooms:192 Stay at the Aava Whistler Hotel (formerly Coast Whistler Hotel) and experience a great vacation. The Aava Whistler Hotel is within minutes from over a hundred shopping malls and restaurants. It also has a great number of recreational facilities, including swimming, diving and even skiing. Hotel services include 24-hour reception, laundry and room service. Guests can stay in cozy rooms equipped with air-conditioning, bathroom and television. From CNY=496 per night. Best Western Cairn Croft Hotel Star Ratings: Location: East Lundy's Lane Room:l66 Relax and unwind at the Best Western Cairn Hotel. This resort-style hotel is located just minutes from the airport. At the Best Western Cairn Croft, guests can enjoy a large number of recreational facilities, including children's activities, sightseeing and a swimming pool. Business travelers can also take advantage of spacious meeting and banqueting facilities for hosting corporate events. All rooms come with basic amenities . From CNY=439 per night. Clarion Hotel&Suites Downtown Montreal Star Ratings: Location:Montreal Rooms:266 Conveniently located just 20 minutes from the airport, the Clarion Hotel&Suite Downtown Montreal is a moderately-priced three-star hotel that provides services to both business and leisure travelers. The Clarion has spacious meeting facilities and modern business centers for business travelers. It also has a sauna and whirlpool where guest can relax. All rooms come with basic amenities, including cable TV and a kitchenette. From CNY=553 per night. Delta Bow Valley Hotel Star Ratings: Location:Calgary Rooms:398 The Delta Bow Valley Hotel is located a couple of blocks north of Olympic Plaza, east of James Short Park, and north-east of the Petro-Canada Centre. Apart from business and recreational services such as a business centre, fitness centre and restaurant, all rooms in the Delta come with a mini-bar and in-house movies. From CNY=l, 227 per night.
Example Output: Which hotel offers facilities for children's activities?

Example Input: Can You Feel Anything When I Do This? is a collection of science fiction short stories by American writer Robert Sheckley, published in December 1971 by Doubleday.
Example Output:
What business published Can You Feel Anything When I Do This??