Given a passage, construct a question on the basis of the information present in the passage. Construct the question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) it answer uses text phrases from the passage. Avoid creating questions that (i) can't be answered correctly without actually understanding the passage and (ii) uses the same words or phrases given in the passage.

Input: Consider Input: Nanoparticles (NPs) in contact with biological fluids become covered by a tightly bound layer of proteins, the "protein corona", and it is largely accepted that this corona gives a new identity to NPs in biological milieu. We here consider the exposing scenario of NPs through an environmental route exemplified by the use of hydrophobins, highly adhesive proteins that are secreted into the environment in large quantities by fungi. HFBII of Trichoderma reesei has been used as a model protein and we have shown strong binding to polystyrene NPs of different sizes and surface groups. Hydrophobin coated NPs are shown to strongly increase the stability and the dispersion when exposed to human plasma compared to pristine ones particles. It is also shown that the presence of hydrophobin on the NPs results in an attenuated protein corona formation, in a different corona composition, and we also show that hydrophobin remained strongly associated to the NPs in competition with plasma proteins. As a conclusion we therefore suggest that the route of exposure of nanoparticles strongly affects their surface properties and their possible physiological behavior.

Output: Does an environmental route of exposure affect the formation of nanoparticle coronas in blood plasma?


Input: Consider Input: The role of sleep in the enhancement of motor skills has been studied extensively in adults. We aimed to determine involvement of sleep and characteristics of spindles and slow waves in a motor skill in children.', 'We hypothesized sleep-dependence of skill enhancement and an association of interindividual differences in skill and sleep characteristics.', '30 children (19 females, 10.7 ± 0.8 years of age; mean ± SD) performed finger sequence tapping tasks in a repeated-measures design spanning 4 days including 1 polysomnography (PSG) night. Initial and delayed performance were assessed over 12 h of wake; 12 h with sleep; and 24 h with wake and sleep. For the 12 h with sleep, children were assigned to one of three conditions: modulation of slow waves and spindles was attempted using acoustic perturbation, and compared to yoked and no-sound control conditions.', 'Mixed effect regression models evaluated the association of sleep, its macrostructure and spindles and slow wave parameters with initial and delayed speed and accuracy.

Output: Do sleep spindle and slow wave frequency reflect motor skill performance in primary school-age children?


Input: Consider Input: The magnitude and duration of postprandial blood glucose elevation seem to be important risk factors for diabetes Type 2 and coronary heart disease. AIM.: To investigate whether post-meal light physical activity might reduce the blood glucose increase.', 'Nine young (18-25 years) and 10 middle-aged (45-65 years) sedentary women, and 10 young and 10 middle-aged trained women participated in a meal/physical activity trial. Commencing after an overnight fast, each subject participated in two experiments, carried out on separate days: Day 1, the subjects were given cornflakes (1 g carbohydrate per kg body weight) to be ingested during 15 min. Blood glucose was determined while resting, before meal, and each 15 min for the next 120 min. Day 2 was similar to Day 1 but included light bicycling exercise for 30 min after finishing the meal.', 'In all trials, irrespective of age and training condition, light bicycling for 30 min after the carbohydrate meal blunted the rise in blood glucose.


Output: Does postprandial light physical activity blunt the blood glucose increase?