TASK DEFINITION: Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.
PROBLEM: The 1980 film Magnificent 72 and the 2011 film 72 Heroes focus on the uprising. Events of the uprising open the 2011 film 1911.

SOLUTION: Which film cam out first, in 1980 Magnificent 72 or 2011 72 Heroes?

PROBLEM: Chronic myeloid leukemia (CML) is characterized by the Philadelphia translocation that fuses BCR sequences from chromosome 22 upstream of the ABL gene on chromosome 9. The chimerical Bcr-Abl protein expressed by CML cells has constitutive tyrosine kinase activity, which is essential for the pathogenesis of the disease. Imatinib, an ATP-competitive selective inhibitor of Bcr-Abl, has unprecedented efficacy for the treatment of CML. Most patients with early stage disease achieve durable complete hematological and complete cytogenetic remissions, with minimal toxicity. In contrast, responses are less stable in patients with advanced CML. This review highlights the pathogenesis of CML, its clinical features, and the development of imatinib as a specific molecularly targeted therapy. Aspects of disease monitoring and side effects are covered as well as resistance to imatinib and strategies to overcome resistance, such as alternative signal transduction inhibitors and drug combinations. Perspectives for further development are also discussed.

SOLUTION: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

PROBLEM: Hermann Friedrich Kohlbrugge, or Kohlbrugge (August 15, 1803, Amsterdam - March 5, 1875, Elberfeld) was a Dutch (German father) minister.

SOLUTION:
Where did Hermann Friedrich Kohlbrugge live when he died?