Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Q: A significant role for IFN in the pathogenesis of systemic lupus erythematosus is well supported, and clinical trials of anti-IFN monoclonal antibodies are in progress in this disease. In other autoimmune diseases characterized by substantial inflammation and tissue destruction, the role of type I interferons is less clear. Gene expression analysis of peripheral blood cells from patients with rheumatoid arthritis and multiple sclerosis demonstrate an interferon signature similar to but less intense than that seen in patients with lupus. In both of those diseases, presence of the interferon signature has been associated with more significant clinical manifestations. At the same time, evidence supports an anti-inflammatory and beneficial role of IFN locally in the joints of patients with rheumatoid arthritis and in murine arthritis models, and many patients with multiple sclerosis show a clinical response to recombinant IFN. As can also be proposed for type I diabetes mellitus, type I interferon appears to contribute to the development of autoimmunity and disease progression in multiple autoimmune diseases, while maintaining some capacity to control established disease - particularly at local sites of inflammation. Recent studies in both rheumatoid arthritis and multiple sclerosis suggest that quantification of type I interferon activity or target gene expression might be informative in predicting responses to distinct classes of therapeutic agents.

A: Which is the most common gene signature in Rheumatoid Arthritis patients?
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Q: My grandmother often said to me, "You can count the number of your true friends on the fingers of one hand." For a long time I thought this was true. However, I've now discovered my grandmother was only half right. Maybe we do only make a few "best" friends in our lifetime, but those aren't the only people that we can call friends. There are many different types. Let me tell you about a few of them. One type of friends is the type I call the "football mom friend". My neighbor Sally is a good example. We both have kids who play football in a football club, and someone has to take them to practice and pick them up. Sally and I and two other mothers take turns to do this. We meet sometimes and have tea and talk about what our kids are doing, but those are the only times that we meet each other. I enjoy being with these women, but we don't do anything else together. Another type is called the "hobby friend". That's the person you share an interest or a hobby with. Michael and Cater, who are brothers, are a good example of this type. We're all in a bird watching club. Every few weekends the members of the club go on a trip to watch different kinds of birds. There's nothing romantic about my relationship with Michael and Cater, of course. We just share interest in birds. Then there's the "other half of the couple" type of friends. Jim is married to Rose, a friend that I've known since college. When Rose married Jim, I realized that I would have to be Jim's friend if I want to continue to be Rose's. Jim and I don't share so many interests, but we do have a friendly relationship.

A: Many people are mentioned in this passage. Who is the writer's true friend?
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Q: Recombinant tissue plasminogen activator (rT-PA) is an effective treatment for acute ischaemic stroke when given within 3h of symptom onset but can be delayed as patients wait for a diagnosis. The ROSIER assessment tool (Fig. 1) has been found to be effective in diagnosing stroke but to date has only been tested when used by doctors. To compare registered nurses' ability to diagnose stroke using the ROSIER assessment tool with doctors' ability to diagnose stroke using traditional neurological assessment. A prospective audit of all suspected stroke patients (n=106) admitted to the stroke unit of a district general hospital over an eight month period, assessed by registered nurses trained to use the ROSIER assessment tool to identify stroke. Time from admission to the stroke unit until initial assessment by doctors and registered nurses. Comparison of initial diagnosis by doctors and registered nurses with final diagnosis by a consultant for stroke. Of 106 suspected stroke patients, 78 (73.5%) had a final diagnosis of stroke or transient ischaemic attack (TIA) and 28 (26.4%) had an alternative diagnosis. Six patients with TIA were subsequently excluded as they were asymptomatic at the time of assessment, leaving 100 participants in the validation phase of the study. Using the ROSIER tool registered nurses achieved a diagnostic sensitivity for stroke of 98% (95% confidence interval 88-99), positive predictive value (PPV) 83% (95% confidence interval 73-90). Doctors using standard neurological assessment had a similar diagnostic sensitivity of 94% (95% confidence interval 86-98), PPV 80% (95% confidence interval 70-88). The mean time from initial assessment by registered nurses using the ROSIER tool, until assessment by doctor on the stroke unit was 75 min (SD=65.8 min). Registered nurses working on a stroke unit using the ROSIER assessment tool are able to diagnose stroke with a degree of accuracy comparable to doctors using clinical neurological assessment. Prompt assessment of suspected stroke patients by registered nurses using the ROSIER tool could reduce delays in eligible stroke patients being assessed for rT-PA treatment.

A:
ROSIER scale is used for which disorder?
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