In this task, you are given a multiple-choice question about healthcare. Answer the question based on your information and classify your answers into '1', '2', '3', and '4'.

Input: Consider Input: Question: What dose should you administer orally every 12 hours of a drug whose plasma clearance is equal to 1 L / h if you want to reach an average concentration of 10mg / L equilibrium? Assume complete bioavailability (F = 1): 
 Options:  <1> 120 mg. <2> 12 mg. <3> 200 mg. <4> 10 mg. <5> With this information it is not possible to estimate the dose necessary to reach this equilibrium concentration.

Output: 1


Input: Consider Input: Question: In the pharmacological treatment of hallucinations and delusions, what is the correct answer? 
 Options:  <1> Between 30-50% of people with psychosis treated with antipsychotics continue to experience difficulties derived from clinical symptoms. <2> Antipsychotics act on the positive symptoms of psychosis, but mainly eliminate the negative symptoms. <3> The extrapyramidal side effects they cause are intractable. <4> When an antipsychotic does not improve symptoms, changing the treatment is not advisable. <5> It is advisable not to combine it with psychological treatment until the psychotic symptoms have disappeared.

Output: 1


Input: Consider Input: Question: When an enzyme catalyzes a reaction: 
 Options:  <1> It is not modified and can be reused. <2> It does not change, but it loses its activity. <3> It always requires the participation of cofactors. <4> It denatures to facilitate bonding with the substrate. <5> It always requires energy.


Output: 1