Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.

[EX Q]: Context: From the outside, the skin looks plain and simple, as you can see in Figure 16.5. But at a cellular level, theres nothing plain or simple about it. A single square inch of skin contains about 20 blood vessels, hundreds of sweat glands, and more than a thousand nerve endings. It also contains tens of thousands of pigment-producing cells. Clearly, there is much more to skin than meets the eye! For a dramatic introduction to the skin, watch this video: MEDIA Click image to the left or use the URL below. URL: The skin is only about 2 mm thick, or about as thick as the cover of a book. Although it is very thin, it consists of two distinct layers, called the epidermis and the dermis. You can see both layers and some of their structures in Figure 16.6. Refer to the figure as you read about the epidermis and dermis below. The epidermis is the outer layer of skin. It consists almost entirely of epithelial cells. There are no blood vessels, nerve endings, or glands in this skin layer. Nonetheless, this layer of skin is very active. It is constantly being renewed. How does this happen? 1. The cells at the bottom of the epidermis are always dividing by mitosis to form new cells. 2. The new cells gradually move up through the epidermis toward the surface of the body. As they move, they produce the tough, fibrous protein called keratin. 3. By the time the cells reach the surface, they have filled with keratin and died. On the surface, the dead cells form a protective, waterproof layer. 4. Dead cells are gradually shed from the surface of the epidermis. As they are shed, they are replaced by other dead cells that move up from below. The epidermis also contains cells called melanocytes. You can see a melanocyte in Figure 16.7. Melanocytes produce melanin. Melanin is a brown pigment that gives skin much of its color. Everyones skin has about the same number of melanocytes per square inch. However, the melanocytes of people with darker skin produce more melanin. The amount of melanin that is produced depends partly on your genes and partly on how much ultraviolet light strikes your skin. The more light you get, the more melanin your melanocytes produce. This explains why skin tans when its exposed to sunlight. The dermis is the inner layer of skin. It is made of tough connective tissue. The dermis is attached to the epidermis by fibers made of the protein collagen. The dermis is where most skin structures are located. Look again at Figure pain, pressure, and temperature. If you cut your skin and it bleeds, the cut has penetrated the dermis and damaged a blood vessel. The cut probably hurts as well because of the nerve endings in this skin layer. The dermis also contains hair follicles and two types of glands. You can see some of these structures in Figure 16.8. Hair follicles are structures where hairs originate. Each hair grows out of a follicle, passes up through the epidermis, and extends above the skin surface. Sebaceous glands are commonly called oil glands. They produce an oily substance called sebum. Sebum is secreted into hair follicles. Then it makes its way along the hair shaft to the surface of the skin. Sebum waterproofs the hair and skin and helps prevent them from drying out. Sweat glands produce the salty fluid known as sweat. Sweat contains excess water, salts, and other waste products. Each sweat gland has a duct that passes through the epidermis. Sweat travels from the gland through the duct and out through a pore on the surface of the skin. You couldnt survive without your skin. It has many important functions. In several ways, it helps maintain homeostasis. The main function of the skin is controlling what enters and leaves the body. It prevents the loss of too much water from the body. It also prevents bacteria and other microorganisms from entering the body. Melanin in the epidermis absorbs ultraviolet light. This prevents the light from reaching and damaging the dermis. The skin helps maintain a constant body temperature. It 
 Question: __major organ of the integumentary system
[EX A]: skin

[EX Q]: Context: The film explores adolescent issues through the minds of three friends and their reactions after a boy named Rudy Carges (Conor Donovan) is killed in a tree house set on fire by local bullies Jeff and Kenny, who carelessly didn't find out he was inside until too late. The boy's twin brother Jacob, a boy with a huge birthmark (also played by Donovan), decides to seek revenge against the bullies. Leonard (Jesse Camacho) who's overweight, survives the tree house fire but loses his sense of taste and smell. Thanks to the fire, this prompts Leonard to go on a diet, which isn't welcomed by his obese family. The boys' female friend Malee (Zoe Weizenbaum) tries to befriend an adult named Gus (Jeremy Renner), a grief-stricken patient of her therapist mother, Carla (Annabella Sciorra). Jacob's family falls apart after the death of his brother. But shortly after, his parents adopt a boy named Keith Gardner. Meanwhile, Malee begins to have a crush on Gus and changes the song for her recital to one Gus liked, just for him. As time goes by, she sees Gus as her "soul mate". She sneaks into his house one night to find him grieving. Afraid to confront him, Malee steals his gun and leaves. She gives it to Jacob the following day. Jacob frequently visits Jeff and Kenny, who are serving time in a juvenile hall. Jacob initially threatens them, until eventually Jeff commits suicide. Jacob befriends Kenny, soon learning he has an early release and is illegally moving to New Mexico. Meanwhile, Leonard's father decides to take his sisters to Florida instead of Leonard (who would usually go). Leonard decides to force his mother to lose weight by trapping her in the cellar. They both end up in the hospital after a gas leak in their home. Next, Jacob and Kenny agree that Jacob can go with him to New Mexico. Malee visits Gus and removes her clothes in an attempt to seduce him. Instead, Gus calls Malee's mother to come and pick her up. The next day, Gus explains to therapist Carla about the last fire he ever fought (which involved killing an injured little girl, upon the girl's request), claiming that Malee wanted him to take her pain away, as he was aware of her growing crush on him. Meanwhile, Jacob's mother tells him that Keith Gardner wasn't adopted to replace Rudy, and that she wants Kenny dead, which reminds Jacob of his planned revenge. The night of escape for Jacob finally comes and he meets up with Kenny. Jacob insists on going through a construction site which he says is a secret route. Once there, Jacob points Gus's gun at Kenny, and tells him "you killed him" before shooting him dead. Jacob buries the body and leaves. He returns in the daytime, and sees Gus spreading cement above Kenny's grave. Malee begins visiting her estranged father and Leonard's family finally starts eating healthily. The movie ends with Jacob's mother smiling at him from inside the house. 
 Question: How many stories are there in this film?
[EX A]: three

[EX Q]: Context: Lack of specific antidotes is a major concern in intracerebral hemorrhage (ICH) related to direct anticoagulants including dabigatran (OAC-ICH). We examined the efficacy of idarucizumab, an antibody fragment binding to dabigatran, in a mouse model of OAC-ICH. Dabigatran etexilate (DE) dose-dependently prolonged diluted thrombin time and tail-vein bleeding time, which were reversed by idarucizumab. Pretreatment with DE increased intracerebral hematoma volume and cerebral hemoglobin content. Idarucizumab in equimolar dose prevented excess hematoma expansion for both DE doses. In more extensive ICH, idarucizumab significantly reduced mortality. Thus, idarucizumab prevents excess intracerebral hematoma formation in mice anticoagulated with dabigatran and reduces mortality. 
 Question: Which drug can be reversed with idarucizumab?
[EX A]:
dabigatran