instruction:
Given a paragraph, generate a claim that is supported by the given paragraph. 1) The claim must contain information from within the paragraph. 2) A sentence within the paragraph can be used as a claim. 3) The claim should not have contradictions within the paragraph. 4) The claim should be at most one sentence long.
question:
"Costs and the cost-effectiveness of this strategy are not discussed. Any discussion of a preventive strategy should include comments on cost. Avandia and metformin, at the doses used in the study, cost about $195 a month, according to drugstore.com. We get absolute benefits, relative benefits, and the all-important number needed to treat (NNT). Very nice. While harms weren’t quantified, the story provided a good amount of detail, context, and caveat about the safety of this regimen. We get many important details about the study: the number of patients, the enrollment criteria, randomization, placebo control, half doses, and the length of follow-up. It also describes some limitations of the study, such as its inability to detect rare adverse events due to its size. It’s an important caveat, particularly with a cardiovascular cloud hanging over rosiglitazone. The author also points to the editorial’s observation that the approach didn’t affect the problems in the pancreas that underly diabetes and which must be addressed by such a strategy. The author is very specific about the thresholds for the patient population, and who was considered at high risk to progress to diabetes. We note that it was judiciously limited in its use of the term ""prevention."" Props to the author for citing the editorial written by two independent experts and published in the same issue of the Lancet. This article selects several of their many cogent comments. Ideally, another independent source outside the publication would’ve been consulted, too. The story describes how GSK has a dog in this fight, funding the study and manufacturing Avandia. The story also provides the institutional affiliations of Zinman and the two editorialists. While it’s probably covered in the GSK funding source, we’ll point out that several investigators had other financial ties to GSK, too. The article talks about the effectiveness of lifestyle changes and the challenge of implementing them. It also reviews the barriers to using full-dose rosi because of adverse events. It’s clear Avandia and metformin are currently available. We’re told of similar prior studies and the novelty of attempting a low-dose regimen to block progression. We don’t see evidence that the article relied on any news releases."
answer:
Low-dose combination of Avandia and metformin decreases progression to diabetes by two-thirds with few side effects


question:
The outbreak comes ahead of the Lunar New Year holiday in late January, when many of China’s 1.4 billion people will be travelling to their home towns or abroad. The World Health Organization and Chinese authorities are taking steps to ensure the disease does not spread further. Thai health authorities said on Wednesday they were stepping up monitoring of passengers arriving at airports with infrared thermal scanners ahead of the holiday, when 800,000 Chinese tourists are expected to visit the country. Memories remain fresh in Asia of a 2002-2003 outbreak of SARS, or Severe Acute Respiratory Syndrome (SARS), which emerged in China and killed nearly 800 people worldwide. WHO has said there may have been limited human-to-human transmission of the new coronavirus in China within families. And authorities in Wuhan confirmed on Wednesday that a married couple were among 41 people diagnosed with pneumonia believed to be caused by the new virus. There were no new cases or deaths at the end of Tuesday, the city’s health authority said. The Wuhan Municipal Health Commission did not say in the statement whether the couple represented an instance of human-to-human transmission. But it said the husband, who worked at a seafood market suspected of being at the epicentre of the outbreak, was the first to fall ill and that his wife did not have any exposure to the market. Some of the other people diagnosed also denied visiting the market, the commission said. The authorities in Wuhan also confirmed that a Chinese woman quarantined in Thailand, the first case of the mystery strain of coronavirus to be detected outside of China, had come from Wuhan. The State Department’s notice referred to an alert by the U.S. Centers for Disease Control and Prevention urging citizens in China travelling to Wuhan to avoid contact with animals, animal markets or animal products, among other precautions. It also asked citizens those who had visited Wuhan and feel sick to seek medical care. The Wuhan health commission said in another statement issued late Wednesday that 7 of the 41 pneumonia patients have been released. The statement also said that 450 of the 763 people put under observation due to their close contact with known patients have been released.
answer:
U.S. warns citizens in China about pneumonia outbreak.


question:
The story did not address costs. Because this ran in the U.S. edition of The Guardian, this is important and useful information for readers stateside, who often have substantial out-of-pocket drug costs. The research examined the side effect profiles of  lithium, valproate, olanzapine, and quetiapine and provided hazard ratios for the most commonly recognized side effects. The Guardian story reflects those findings in a qualitative way with some quantitative details, such as: “Meanwhile, lithium patients were less likely to put on weight than patients on the other drugs. While 15%-20% of those on the three other drugs were more likely to gain more than 15% of their body weight, just 10% of those on lithium put on the same amount of extra pounds.” The story does a reasonable job in outlining the side effects seen with the four drugs in question and provides them in context. The reader is told: “The researchers studied a nationally representative sample of 6,671 patients across the UK who were treated for bipolar disorder between 1995 and 2013. Of those, 2,148 had taken lithium, 1,670 had used valproate, 1,477 had been on olanzapine and 1,376 had taken quetiapine. They experienced side-effects including chronic kidney disease, thyroid disease, weight gain and high blood pressure.” These are important details, but we also wanted to see some nod to the caveats of the study, which were noted by the researchers in their paper in the “strengths and limitations” section. There is no evidence of disease mongering. Given the seriousness of the disorder and its prevalence, we would have liked to have seen read more on how many people it affects. Although the majority of the quotes come from a senior author of the research, the comments of Stephen Buckley, head of information at the charity Mind were welcomed and provided an important second voice. A few words from other clinicians would have been a bonus. The research examined the side effect profiles of the most commonly used drugs to treat bipolar disorder, it also discusses “talk therapy” (but not until the end of the story). The story makes it clear that the four drugs studied are indeed available. The story begins with: The new study is the first to compare the side-effects of the four main mood-stabilising drugs prescribed by the NHS.”  Based on our review of the medical literature, we agree. The story does not appear to rely on a news release.
answer:

Lithium should be more widely used for bipolar disorder, researchers say