Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

[EX Q]: Imatinib mesylate is a new drug that can inhibit the tyrosine kinase activity of Bcr-Abl, the receptors for platelet-derived growth factor receptor(PDGF) and stem cell factor, or c-kit. Chronic myeloid leukemia (CML) is distinguished by the presence of a reciprocal translocation between chromosomes 9 and 22 that results in a shortened chromosome 22, termed the Philadelphia(Ph) chromosome. As a result of the translocation, a fusion gene called the Bcr-Abl gene is created from two normal cellular genes, encoding a chimeric Bcr-Abl protein with a deregulated tyrosine kinase activity. The expression of Bcr-Abl tyrosine kinase has been shown to be necessary and sufficient for the transformed phenotype of CML cells. Imatinib can block the kinase activity of Bcr-Abl, thus inhibiting the proliferation of Ph-positive progenitors, and has shown activity against all phases of CML, though responses are most substantial and durable in patients in the chronic phase. An international phase III study which compared the efficacy of imatinib with that of interferon alpha combined with low-dose cytarabine in newly diagnosed chronic-phase CML showed the rate of major cytogenetic response at 24 months was 90%, including 82% of complete cytogenetic response. These results indicated that imatinib was superior to interferon-containing treatment as a first-line therapy. More than 10,000 patients worldwide, including those in Japan, have been treated with imatinib in clinical trials, and a lot of information has been accumulated on the use of this drug. The aim of this article is to review the use of this drug and the practical management of patients with chronic myeloid leukemia.
[EX A]: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

[EX Q]: In 1997 the Kymi Province was merged with the Uusimaa Province and the southern parts of the Hame Province into the new Southern Finland Province.
[EX A]: What was replaced Kymi Province?

[EX Q]: April 11, 2003 12:44 a. m. PST, Associated Press The respiratory virus known as SARS has appeared to spread in the United States only to family members of health workers with close contact to a sick person. On Thursday, the head of the Centers for Disease Control and Prevention said there might be a case of severe acute respiratory syndrome spreading through the workplace. Dr. Julie Gerberding said a suspected SARS virus patient who became ill after traveling to Asia might have infected a co-worker in Florida, which made her "very worried". So far, a dozen people--nine family members and three health workers--were infected after coming into close contact with the person with SARS. The rest of the 166 suspected American cases have something to do with people who were infected while traveling in Asia. In the Gainesville, Fla. area, a 47-year-old woman was believed to have been infected at work by a 60-year-old woman who was the nation's first suspected SARS case, said Tom Belcuore, director of the Alachua County health department. Since the World Health Organization announced a worldwide warning last month about SARS, the United States has started infection control in hospitals and among families of suspected cases. Florida officials said a school in Okaloosa County went through a cleaning after a 6-year-old boy suspected of having SARS appeared at school with slight symptoms. "Health officials are watching the boys' contacts at school to make sure no one else is infected," said Rob Hayes, health department spokesman, "The boy may have been infected from a family member," Hayes said, "We immediately became aware of it and had the child sent home. He's staying at home with his family until 10 days after symptoms disappear." The researchers guessed that the virus might have come from animals. However, the scientists have not ruled out the possibility that some other microbe might also help make SARS more serious or easier to catch.
[EX A]:
How many cases of suspected SARS are there in the U.S.A. according to the text?