TASK DEFINITION: Given a question and a context passage, generate the answer having the word or phrase from the context passage. Here, the answer should be a shortest continous span from the passage.
PROBLEM: Context: We show that overexpression of Polo-like kinase 4 (Plk4) in human cells induces centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole. This provided an opportunity for dissecting centriole assembly and characterizing assembly intermediates. Critical components were identified and ordered into an assembly pathway through siRNA and localized through immunoelectron microscopy. Plk4, hSas-6, CPAP, Cep135, gamma-tubulin, and CP110 were required at different stages of procentriole formation and in association with different centriolar structures. Remarkably, hSas-6 associated only transiently with nascent procentrioles, whereas Cep135 and CPAP formed a core structure within the proximal lumen of both parental and nascent centrioles. Finally, CP110 was recruited early and then associated with the growing distal tips, indicating that centrioles elongate through insertion of alpha-/beta-tubulin underneath a CP110 cap. Collectively, these data afford a comprehensive view of the assembly pathway underlying centriole biogenesis in human cells. 
 Question: Where in the cell do we find the protein Cep135?

SOLUTION: centrosome

PROBLEM: Context: Imatinib mesylate is a new drug that can inhibit the tyrosine kinase activity of Bcr-Abl, the receptors for platelet-derived growth factor receptor(PDGF) and stem cell factor, or c-kit. Chronic myeloid leukemia (CML) is distinguished by the presence of a reciprocal translocation between chromosomes 9 and 22 that results in a shortened chromosome 22, termed the Philadelphia(Ph) chromosome. As a result of the translocation, a fusion gene called the Bcr-Abl gene is created from two normal cellular genes, encoding a chimeric Bcr-Abl protein with a deregulated tyrosine kinase activity. The expression of Bcr-Abl tyrosine kinase has been shown to be necessary and sufficient for the transformed phenotype of CML cells. Imatinib can block the kinase activity of Bcr-Abl, thus inhibiting the proliferation of Ph-positive progenitors, and has shown activity against all phases of CML, though responses are most substantial and durable in patients in the chronic phase. An international phase III study which compared the efficacy of imatinib with that of interferon alpha combined with low-dose cytarabine in newly diagnosed chronic-phase CML showed the rate of major cytogenetic response at 24 months was 90%, including 82% of complete cytogenetic response. These results indicated that imatinib was superior to interferon-containing treatment as a first-line therapy. More than 10,000 patients worldwide, including those in Japan, have been treated with imatinib in clinical trials, and a lot of information has been accumulated on the use of this drug. The aim of this article is to review the use of this drug and the practical management of patients with chronic myeloid leukemia. 
 Question: What tyrosine kinase, involved in a Philadelphia- chromosome positive chronic myelogenous leukemia, is the target of Imatinib (Gleevec)?

SOLUTION: bcr-abl

PROBLEM: Context: The plot is 24 hours in the life of a glamorous fashion photographer named Thomas (David Hemmings), inspired by the life of an actual "Swinging London" photographer, David Bailey.In the opening scene, Thomas wakes up after spending the night at a doss house where he has taken pictures for a book of art photos. He is late for a photo shoot with Veruschka von Lehndorff (playing herself) at his studio, which in turn makes him late for a shoot with other models later in the morning. He grows bored and walks off, leaving the models and production staff in the lurch. As he leaves the studio, two teenage girls who are aspiring models, a blond (Jane Birkin) and a dark-haired brunette (Gillian Hills) ask to speak with him, but the photographer drives off to look at an antiques shop.Wandering into Maryon Park, he takes photos of two lovers making out. The woman (Vanessa Redgrave) is furious at being photographed and demands that Thomas hand over the film, but he refuses. When she walks away to rejoin her boyfriend, he is gone and she runs away with Thomas taking photos of her as she runs.Thomas then meets his agent for lunch, and notices a man following him and looking into his car. Back at his studio, the mysterious woman from the park arrives asking for the film, but he refuses. The woman introduces herself as 'Jane' and tries to seduce Thomas by removing her top to entice him to hand over the film and negatives. Thomas agrees without going any further, but he deliberately hands Jane a different roll. She in turn writes down a telephone number to give to him.After Jane leaves, Thomas begins work on developing his photos that he took that day. His many enlargements of the black and white film are grainy but he finds something strange. In the Maryon Park photos, Thomas notices a figure hiding in the bushes near Jane and her boyfriend and upon enlarging them in a series of 'blow-up' shots, sees that it is a man with a gun (the same man he saw following him earlier). In the shots where Jane is running away with her back to the camera, Thomas also notices something on the ground in the distance. The blow-up shots of the blurred figure on the ground that Jane is running to appears to be a body in the grass. Thomas gets the feeling that he just witnessed the before and afterwards of a murder.Thomas is disturbed by a knock on the door, but it is only the two girls again, with whom he has a group-sex romp in his studio and falls asleep. Awakening, he finds they hope he will photograph them but he tells them to leave, saying, "Tomorrow! Tomorrow!"As evening falls, Thomas goes back to the park to investigate and finds a dead body (Jane's dead lover), but he has not brought his camera and is scared off by a twig breaking, as if being stepped on by someone unseen watching him. Thomas returns to his studio to find that someone (possibly Jane and her gunman accomplice) has broken into his place and all the negatives and prints from the park are gone except for one large, very grainy blowup showing the body (which proves nothing). He tries to call the phone number Jane gave him, but learns from the operator that the number does not exist.After driving into town, Thomas sees Jane walking alone on a sidewalk and he pulls his car over and follows her on foot into a night club where The Yardbirds, featuring both Jimmy Page and Jeff Beck on guitar, are seen playing. Thomas moves to confront Jane, but she sees him and runs. Thomas loses her on the crowded street.Thomas then goes to a drug-drenched party in a house on the Thames near central London. He finds a strung-out Veruschka, who had told him that she was going to Paris, and when confronted, she says she is in Paris. Thomas then meets his agent Ron (Peter Bowles), whom he wants to bring to the park 
 Question: Who writes down a false telephone number?

SOLUTION:
jane