Given a context passage, generate a question from the passage such that its answer is shortest continous span from the passage.

Protein kinases (PKs) and lipid kinases (LKs) are good choices for targets of signal transduction therapy as these enzymes are involved in signaling pathways, and are often related to the pathogenesis of lymphoid malignancies. The attractiveness of PKs and LKs as drug able targets is enhanced by the fact that they are enzymes whose biological activity can be turned off by drugs that block their catalytic site. In the last few years small molecular kinase inhibitors (KIs) have been synthesized and become available for preclinical studies and clinical trials. The first KI, introduced into clinical practice in 1998, was imatinib mesylate, which became the first choice drug in chronic myeloid leukemia. More recently, several KIs have been developed to target the proximal B-cell receptor (BCR) signaling pathway including spleen tyrosine kinase inhibitor (Fostamatinib) and Bruton's tyrosine kinase inhibitors (Ibrutinib, AVL-263). These agents are currently evaluated in early clinical trials in chronic lymphocytic leukemia (CLL) and other diseases. Cyclin-dependent kinase (Cdk) inhibitors, flavopiridol (alvocidib), BMS-387032 (SNS-032), sunitinib and sorafenib are currently under evaluation in clinical trials for relapsed/refractory CLL. Multi-tyrosine kinase inhibitors including vandetanib (ZD6474) bosutinib (SKI-606), TKI258 (CHIR-258), pazopanib (GW786034) and axitinib (AG013736) have been also developed for the treatment of lymphoid malignancies. Phosphatidylinositol 3-kinases (PI3K ) are a family of lipid kinases that mediate signals from cell surface receptors. CAL-101 (GS-1101) is an oral PI3K-specific inhibitor which has shown preclinical and clinical activity against CLL. This article summarizes recent achievements in the mechanism of action, pharmacological properties and clinical activity and toxicity of PK and LK inhibitors in CLL.
What is the name of Bruton's tyrosine kinase inhibitor that can be used for treatment of chronic lymphocytic leukemia?

Many patients with restless legs syndrome (Willis-Ekbom disease) complain of burning sensations in their feet associated with the desire to move, such that they seek cooler environments. This pilot study aimed to characterise the microvascular skin changes in 12 patients with restless legs syndrome compared with 12 age- and sex-matched controls. Patients with moderate or severe restless legs syndrome and controls underwent detailed thermovascular assessment in a controlled temperature room at three different stages (normothermic phase 23C, hot phase 30C, cold phase 18C). Microvascular activity was recorded during all phases by bilateral great toe laser-Doppler flowmetry and also by whole-body thermography. Patient and control measurements were compared. The study protocol was well tolerated. Parameters extracted from the laser-Doppler flowmetry measurements were used to model a logistic function using binary logistic regression. This demonstrated a statistically significant difference between patients with restless legs syndrome and healthy controls (P<0.001). Visual inspection of the body thermography image sequences showed increased lower limb movement in patients with restless legs syndrome patients compared with controls. Thermography analysis also showed significant differences between foot temperatures in patients with restless legs syndrome compared with controls during the hot phase (P=0.011). Notably, patients with restless legs syndrome had more uniform foot temperatures, whereas controls had a wider variability in surface temperature across the feet. This novel study demonstrates impaired microvascular circulation in patients with restless legs syndrome in comparison to matched controls and a potential mechanism for the sensation of burning feet. The protocol also provides an experimental paradigm to test therapeutic interventions for the future.
Willis-Ekbom disease is also known as?

When it comes to hotel pools, the indoor variety has long been inferior to their outdoor -- often rooftop -- counterparts. But these days, striking decoration, luxury facilities and stunning settings mean many indoor swimming holes can now challenge even the most glamorous of outdoor pools. So go ahead and take a dip at these luxurious indoor pools. The Water Club at Borgata, Atlantic City This nongaming hotel, which is part of the large Borgata complex in Atlantic City, has three indoor pools (and two more outdoors) so there's really no reason for things to get crowded at any of them. A two-lane lap pool is in the two-floor Immersion spa on the 32nd floor and is set against full-length windows that look out to the Atlantic Ocean, the perfect setup for a water workout. An extremely attractive top-floor pool surrounded by lounge chairs, cabanas and lush foliage expresses a more exotic tropical scene than the property's Jersey Shore location. Rooms from $249/ night. www.theborgata.com Altira Macau On the 16th floor of the tallest building on the island of Taipa is the glamorous indoor infinity pool of the impressively massive gaming complex of Altira Macau. It's easy to see why Forbes once named it one of the best hotel pools in the world: One side faces all of the city with crystal-clear floor-to-ceiling windows. Rooms from $235/ night. www.altiramacau.com Waldorf Astoria Chicago The spa at this hotel is done mostly in a stark white, which only further emphasizes the gorgeous rose-design tile-work at the bottom of the pool, giving bathers the feel of swimming over a bed of roses. The 102,600 individually patterned tiles come from Bisazza, an Italian company renowned for its mosaic tile production. Rooms from $435/night, double occupancy. www.waldorfastoriachicagohotel.com The Charles Hotel, Munich One of the largest pools in Munich, at The Charles Hotel, is also one of the most beautiful. The entire spa is outfitted with marble mosaic tiles, mostly in subdued color1s punctuated with red flourishes. At the pool itself, a very pretty mosaic of red coral shows respect to the 19th century Bavarian royalty, the Wittelsbach family, known for its collection of red coral paraphernalia, from dining cups to jewelry. Rooms from $375/ night, double occupancy. www.roccofortehotels.com

In which of the hotel pools can you look out to the city from one of the side?