GitHub repository: naseermk/3Dtumorsimulator
Primary language: MATLAB
Created: 2019-05-29T18:15:45Z
Description: simulated the spatiotemporal dynamics of a multicellular tumor using a three-dimensional (3D) agent-based model, in which the cells in the tumor are represented as interacting objects. In this model, the cells grow stochastically as a function of time and divide upon reaching a critical size. The cell-to-cell interaction is characterized by direct elastic and adhesive forces. We also consider cell-to-cell and cell-to-matrix damping as a way of accounting for the effects of friction experienced by a moving cell because of other cells and by the extracellular matrix (ECM) (or collagen matrix), respectively.  Each cell is modeled as a deformable sphere with a time-dependent radius. Several physical properties, such as the radius, elastic modulus, membrane receptor and ligand concentration, and adhesive interaction, characterize each cell.