1980–81 Aston Villa F.C. season First Division First Division

| Date_ | Opponent | Venue | Result_ | Attendance |
|---|---|---|---|---|
| 18 October 1980 | Tottenham Hotspur | Villa Park | 3–0 | 30940 |
| 22 October 1980 | Brighton & Hove Albion | Villa Park | 4–1 | 27367 |
| 25 October 1980 | Southampton | The Dell | 2–1 | 21249 |
| 1 November 1980 | Leicester City | Villa Park | 2–0 | 29953 |
| 8 November 1980 | West Bromwich Albion | The Hawthorns | 0–0 | 34195 |
| 12 November 1980 | Norwich City | Carrow Road | 3–1 | 17050 |
| 15 November 1980 | Leeds United | Villa Park | 1–1 | 29106 |
| 22 November 1980 | Liverpool | Anfield | 1–2 | 48114 |
| 29 November 1980 | Arsenal | Villa Park | 1–1 | 30140 |
| 6 December 1980 | Middlesbrough | Ayresome Park | 1–2 | 15597 |
| 11 December 1980 | Birmingham City | Villa Park | 3–0 | 41101 |
| 20 December 1980 | Brighton & Hove Albion | Goldstone Ground | 0–1 | 16425 |