2006 Cincinnati Reds season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 23 | Cubs | 11 - 4 | Lohse (2-5) | 28264 | 75-79 |
| September 24 | Cubs | 3 - 2 | Dempster (1-9) | 22226 | 76-79 |
| September 25 | Cubs | 5 - 4 | Eyre (1-3) | 16278 | 77-79 |
| September 26 | @ Marlins | 5 - 3 | Willis (12-12) | 11422 | 78-79 |
| September 27 | @ Marlins | 7 - 2 | Michalak (2-4) | 13295 | 78-80 |
| September 28 | @ Marlins | 5 - 1 | Nolasco (11-11) | 14106 | 79-80 |
| September 29 | @ Pirates | 5 - 2 | Duke (10-15) | 27033 | 80-80 |
| September 30 | @ Pirates | 3 - 0 | Arroyo (14-11) | 35514 | 80-81 |