1980–81 Coupe de France Round of 16 Round of 16

| Team_1 | Score | Team_2 | _1st_round | _2nd_round |
|---|---|---|---|---|
| SEC Bastia (D1) | 3 - 2 | AS Monaco (D1) | 2 - 0 | 1 - 2 |
| FC Nantes (D1) | 5 - 10 | Girondins de Bordeaux (D1) | 1 - 4 | 4 - 6 |
| AS Nancy (D1) | 3 - 4 | AS Saint-Étienne (D1) | 2 - 1 | 1 - 3 |
| LB Châteauroux (D2) | 1 - 2 | Lille OSC (D1) | 1 - 0 | 0 - 2 |
| Le Havre AC (D2) | 1 - 2 | RC Lens (D1) | 1 - 0 | 0 - 2 |
| FC Metz (D1) | 2 - 2 | Montpellier HSC (D2) | 2 - 1 | 0 - 1 |