2006 Chicago Cubs season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 13 | Dodgers | 6–0 | Guzmán (0–6) | 35868 | 58–88 |
| September 14 | Dodgers | 6–5 | Tomko (8–7) | 31361 | 59–88 |
| September 15 | Reds | 4–0 | Mármol (5–7) | 37188 | 59–89 |
| September 16 | Reds | 4–0 | Michalak (1–3) | 40526 | 60–89 |
| September 17 | Reds | 11–3 | Milton (8–8) | 39164 | 61–89 |
| September 18 | @ Phillies | 11–6 | Lieber (8–10) | 31101 | 62–89 |
| September 19 | @ Phillies | 4–1 | Miller (0–2) | 31892 | 62–90 |
| September 20 | @ Phillies | 6–2 | Walrond (0–1) | 35269 | 62–91 |
| September 22 | @ Reds | 4–2 | Hill (6–7) | 21332 | 62–92 |
| September 23 | @ Reds | 11–4 | Lohse (2–5) | 28264 | 63–92 |
| September 24 | @ Reds | 3–2 | Dempster (1–9) | 22226 | 63–93 |
| September 25 | @ Reds | 5–4 | Eyre (1–3) | 16278 | 63–94 |