1980–81 FA Cup Second Round Proper Second Round Proper

| Tie_no | Home_team | Score | Away_team | Date_ |
|---|---|---|---|---|
| 9 | Fulham | 1–0 | Brentford | 13 December 1980 |
| 10 | Plymouth Argyle | 3–0 | Oxford United | 13 December 1980 |
| 11 | Millwall | 0–1 | Exeter City | 13 December 1980 |
| 12 | Hull City | 1–1 | Blyth Spartans | 13 December 1980 |
| Replay | Blyth Spartans | 2–2 | Hull City | 16 December 1980 |
| Replay | Hull City | 2–1 | Blyth Spartans | 22 December 1980 |
| 13 | Carlisle United | 3–0 | Walsall | 13 December 1980 |
| 14 | Wimbledon | 2–0 | Swindon Town | 13 December 1980 |
| 15 | St Albans City | 1–1 | Torquay United | 13 December 1980 |
| Replay | Torquay United | 4–1 | St Albans City | 17 December 1980 |
| 16 | Scunthorpe United | 0–0 | Altrincham | 13 December 1980 |
| Replay | Altrincham | 1–0 | Scunthorpe United | 15 December 1980 |