2005 CFL Draft Round Six Round Six

| Pick_ | CFL_Team | Player | Position_ | College |
|---|---|---|---|---|
| 45 | Calgary Stampeders | Brett Ralph | WR | Alberta |
| 46 | Ottawa Renegades | Lenard Semajuste | FB | Adams State |
| 47 | Winnipeg Blue Bombers | Ryan Bisson | OL | Northwood |
| 48 | Saskatchewan Roughriders | Ryan Gottselig | DL | Saskatchewan |
| 49 | Montreal Alouettes (via Edmonton) | Adam Eckert | WR | Dickinson State |
| 50 | Hamilton Tiger-Cats | Andrew Paopao | DL | San Jose State |
| 51 | Montreal Alouettes | Olivier Manigat | OL | Columbia |
| 52 | BC Lions | Karl Ortmanns | OL | Acadia |