List of Seattle Mariners Opening Day starting pitchers Pitchers Pitchers

| Season | Pitcher | Decision | Opponent | Location_ |
|---|---|---|---|---|
| 2003 | Freddy García Category:Articles with hCards (3) | L | Oakland Athletics | Network Associates Coliseum |
| 2004 | Jamie Moyer Category:Articles with hCards (2) | L | Anaheim Angels | Safeco Field |
| 2005 | Jamie Moyer Category:Articles with hCards (3) | W | Minnesota Twins | Safeco Field |
| 2006 | Jamie Moyer Category:Articles with hCards (4) | ND (L) | Los Angeles Angels of Anaheim | Safeco Field |
| 2007 | Félix Hernández Category:Articles with hCards | W | Oakland Athletics | Safeco Field |
| 2008 | Érik Bédard Category:Articles with hCards | ND (W) | Texas Rangers | Safeco Field |
| 2009 | Félix Hernández Category:Articles with hCards (2) | W | Minnesota Twins | Hubert H. Humphrey Metrodome |
| 2010 | Félix Hernández Category:Articles with hCards (3) | ND (W) | Oakland Athletics | Oakland-Alameda County Coliseum |