1978 San Diego Chargers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 3, 1978 | at Seattle Seahawks | W 24–20 | 55778 |
| 2 | September 10, 1978 | Oakland Raiders | L 21–20 | 51653 |
| 3 | September 17, 1978 | at Denver Broncos | L 27–14 | 74983 |
| 4 | September 24, 1978 | Green Bay Packers | L 24–3 | 42755 |
| 5 | October 1, 1978 | at New England Patriots | L 28–23 | 60781 |
| 6 | October 8, 1978 | Denver Broncos | W 23–0 | 50077 |
| 7 | October 15, 1978 | Miami Dolphins | L 28–21 | 50637 |
| 8 | October 22, 1978 | at Detroit Lions | L 31–14 | 54031 |
| 9 | October 29, 1978 | at Oakland Raiders | W 27–23 | 52612 |
| 10 | November 5, 1978 | Cincinnati Bengals | W 22–13 | 43639 |