1991 Buffalo Bills season NFL Draft NFL Draft

| Round_ | Pick_ | Player | Position_ | College |
|---|---|---|---|---|
| 1 | 26 | Henry Jones | Defensive Back | Illinois |
| 2 | 54 | Phil Hansen | Defensive end | North Dakota State |
| 3 | 82 | Darryl Wren | Defensive back | Pittsburg State |
| 4 | 138 | Shawn Wilbourn | Defensive Back | Long Beach State |
| 5 | 166 | Millard Hamilton | Wide receiver | Clark University |
| 6 | 194 | Amir Rasul | Running back | Florida A&M |
| 8 | 222 | Brad Lamb | Wide receiver | Anderson |
| 9 | 249 | Mark Maddox | Linebacker | Northern Michigan |
| 10 | 277 | Tony DeLorenzo | Guard | New Mexico State |
| 11 | 305 | Dean Kirkland | Guard | Washington |