2010–11 Belgian Pro League During summer break During summer break

| Team | Outgoing_manager | Manner_of_departure | Date_of_vacancy | Replaced_by | Date_of_appointment |
|---|---|---|---|---|---|
| Charleroi | Tommy Craig | Sacked | 14 April 2010 (Dutch) | Jacky Mathijssen | 4 June 2010 (Dutch) |
| Lokeren | Emilio Ferrera | Contract ended. | 26 April 2010 (Dutch) | Peter Maes | 20 May 2010 |
| Germinal Beerschot | Jos Daerden | Contract ended. | End of 2009-10 season | Glen De Boeck | 21 May 2010 |
| Mechelen | Peter Maes | Signed for Lokeren . | 20 May 2010 | Marc Brys | 27 May 2010 |
| Cercle Brugge | Glen De Boeck | Signed for Germinal Beerschot . | 21 May 2010 | Bob Peeters | 26 May 2010 |
| Gent | Michel Preud`homme | Signed for Twente . | 23 May 2010 | Francky Dury | 10 June 2010 |