List of highway route numbers in Oregon Mainline routes Mainline routes

| Number_ | South_west_end | North_east_end | Formed | Eliminated_ |
|---|---|---|---|---|
| Oregon Route 452 | OR 201 southwest of Adrian | SH-18 towards Parma, ID | 2003 |  |
| Oregon Route 453 | OR 454 southeast of Adrian | Idaho state line | 2003 |  |
| Oregon Route 454 | OR 452 southeast of Adrian | Idaho state line | 2003 |  |
| Oregon Route 501 | Southwest of Alsea | OR 34 at Alsea | 2002 |  |
| Oregon Route 528 | OR 126B in Springfield | OR 126 in Springfield | 2002 |  |
| Oregon Route 540 | Cape Arago State Park | US 101 in North Bend | 2003 |  |
| Oregon Route 542 | Powers | OR 42 southeast of Myrtle Point | 2003 |  |
| Oregon Route 551 | OR 99E southwest of Aurora | I-5 in Wilsonville | 2002 |  |
| Oregon Route 569 | OR 126 in Eugene | I-5 in Springfield | 2007 |  |