2008–09 U.S. Città di Palermo season Competitions Serie A - Matches

| Date_ | Opponent | Venue | Result_ | Scorers | Report_ |
|---|---|---|---|---|---|
| August 30, 2008 – 18:00 | Udinese | Away | Lost 1–3 | Bresciano | 18 |
| September 13, 2008 – 18:00 | AS Roma | Home | Won 3–1 | Miccoli (2), Cavani |  |
| September 21, 2008 – 15:00 | Genoa | Home | Won 2–1 | Bovo, Cavani | 4 |
| September 24, 2008 – 15:00 | Napoli | Away | Lost 2–1 | Miccoli |  |
| September 28, 2008 – 15:00 | Reggina | Home | Won 1–0 | Miccoli |  |
| October 5, 2008 – 15:00 | Juventus | Away | Won 2–1 | Miccoli, Mchedlidze |  |
| October 19, 2008 - 15:00 | Catania | Away | Lost 0–2 |  | Report |
| October 26, 2008 - 20:30 | Fiorentina | Home | Lost 1–3 | Simplício | Report |
| October 29, 2008 – 20:30 | Lecce | Away | Drew 1–1 | Cavani | Report |