United States House of Representatives elections, 2000 South Carolina South Carolina

| District | Incumbent | Party | First_elected | Results | Candidates |
|---|---|---|---|---|---|
| South Carolina 1 | Mark Sanford | Republican | 1994 | Retired Republican hold | Henry Brown (R) 60% Andy Brack (D) 36% |
| South Carolina 2 | Floyd Spence | Republican | 1970 | Re-elected | Floyd Spence (R) 58% Jane Frederick (D) 41% |
| South Carolina 3 | Lindsey Graham | Republican | 1994 | Re-elected | Lindsey Graham (R) 68% George Brightharp (D) 31% |
| South Carolina 4 | Jim DeMint | Republican | 1998 | Re-elected | Jim DeMint (R) 80% |
| South Carolina 5 | John Spratt | Democratic | 1982 | Re-elected | John Spratt (D) 59% Carl Gullick (R) 40% |