2005 Jacksonville Jaguars season Regular season Regular season

| Week | Date_ | Opponent | Result_ | Record | Game_site |
|---|---|---|---|---|---|
| 1 | September 11 | Seattle Seahawks | W 26–14 | 1–0 | Alltel Stadium |
| 2 | September 18 | at Indianapolis Colts | L 10–3 | 1–1 | RCA Dome |
| 3 | September 25 | at New York Jets | W 26–20 (OT) | 2–1 | The Meadowlands |
| 4 | October 2 | Denver Broncos | L 20–7 | 2–2 | Alltel Stadium |
| 5 | October 9 | Cincinnati Bengals | W 23–20 | 3–2 | Alltel Stadium |
| 6 | October 16 | at Pittsburgh Steelers | W 23–17 (OT) | 4–2 | Heinz Field |
| 7 | Bye | Bye | Bye | Bye | Bye |
| 8 | October 30 | at St. Louis Rams | L 24–21 | 4–3 | Edward Jones Dome |
| 9 | November 6 | Houston Texans | W 21–14 | 5–3 | Alltel Stadium |