USA Today All-USA high school football team 2012 team Second Team Defense

| Player | Position_ | School | Hometown | College |
|---|---|---|---|---|
| Jonathan Allen | Defensive line | Stone Bridge High School | Ashburn, Virginia | Alabama |
| Da`Shawn Hand ‡ | Defensive line | Woodbridge High School | Woodbridge, Virginia | Undecided |
| Tim Williams ‡ | Defensive line | University Lab School | Baton Rouge, Louisiana | Undecided |
| Joey Bosa | Defensive line | St. Thomas Aquinas High School | Fort Lauderdale, Florida | Ohio State |
| A`Shawn Robinson | Defensive line | Arlington Heights High School | Fort Worth, Texas | Alabama |
| Eddie Vanderdoes | Defensive line | Placer High School | Placer, California | Notre Dame |
| Michael Hutchings | Linebacker | De La Salle High School | Concord, California | Southern California |
| Mark Fossati ‡ | Linebacker | St. Joseph High School | Montvale, New Jersey | Undecided |