2000 San Diego Chargers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Game_Site | Record | Attendance |
|---|---|---|---|---|---|---|
| 1 | September 3, 2000 | at Oakland Raiders | L 6–9 | Network Associates Coliseum | 0–1 | 56373 |
| 2 | September 10, 2000 | New Orleans Saints | L 27–28 | Qualcomm Stadium | 0–2 | 51300 |
| 3 | September 17, 2000 | at Kansas City Chiefs | L 10–42 | Arrowhead Stadium | 0–3 | 77604 |
| 4 | September 24, 2000 | Seattle Seahawks | L 12–20 | Qualcomm Stadium | 0–4 | 47233 |
| 5 | October 1, 2000 | at St. Louis Rams | L 31–57 | Trans World Dome | 0–5 | 66010 |
| 6 | October 8, 2000 | Denver Broncos | L 7–21 | Qualcomm Stadium | 0–6 | 56079 |
| 7 | October 15, 2000 | at Buffalo Bills | L 24–27 | Ralph Wilson Stadium | 0–7 | 72351 |