Strikeout Pitchers Pitchers

| Pitcher | Strikeouts | Season | Team | League | Overall_Rank |
|---|---|---|---|---|---|
| Matt Kilroy | 513 | 1886 | Baltimore Orioles | AA | 1 |
| Toad Ramsey | 499 | 1886 | Louisville Colonels | AA | 2 |
| Dupee Shaw | 451 | 1884 | Detroit Wolverines / Boston Reds | NL/UA | 4 |
| Old Hoss Radbourn | 441 | 1884 | Providence Grays | NL | 5 |
| Charlie Buffington | 417 | 1884 | Boston Beaneaters | NL | 6 |
| Guy Hecker | 385 | 1884 | Louisville Eclipse | AA | 7 |
| Nolan Ryan | 383 | 1973 | California Angels | AL | 8 |
| Sandy Koufax | 382 | 1965 | Los Angeles Dodgers | NL | 9 |