2000 Cleveland Indians season Game log May

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| May 21 | Yankees | 6 - 1 | Hernandez (4-4) | 42587 | 23-17 |
| May 23 | @ Tigers | 10 - 4 | Colón (4-2) | 27039 | 23-18 |
| May 24 | @ Tigers | 10 - 9 | Watson (0-1) | 27274 | 23-19 |
| May 25 | @ Tigers | 4 - 1 | Moehler (1-3) | 30103 | 24-19 |
| May 26 | @ White Sox | 5 - 3 | Finley (3-4) | 18225 | 24-20 |
| May 27 | @ White Sox | 14 - 3 | Wright (3-3) | 30250 | 24-21 |
| May 28 | @ White Sox | 12 - 3 | Wells (3-4) | 24192 | 25-21 |
| May 29 | Angels | 3 - 2 (10) | Karsay (0-3) | 42888 | 25-22 |
| May 30 | Angels | 6 - 1 | Schoeneweis (5-3) | 42910 | 26-22 |
| May 31 | Angels | 7 - 3 | Etherton (0-1) | 41637 | 27-22 |