2005–06 U.S. Città di Palermo season Serie A Serie A

| Date_and_time | Opponent | Venue | Result_ | Attendance |
|---|---|---|---|---|
| August 28, 2005 – 15.00 | Parma | Away | Drew 1-1 | 12733 |
| September 10, 2005 – 18.00 | Inter | Home | Won 3-2 | 31309 |
| September 18, 2005 – 15.00 | Siena | Away | Won 2-1 | 7492 |
| September 21, 2005 – 20.30 | Reggina | Home | Won 1-0 | 28145 |
| September 25, 2005 – 15.00 | Lazio | Away | Lost 2-4 | 23935 |
| October 2, 2005 – 15.00 | Empoli | Home | Drew 2-2 | 26642 |
| October 16, 2005 – 15.00 | Chievo | Home | Drew 2-2 | 27092 |
| October 23, 2005 – 15.00 | AC Milan | Away | Lost 1-2 | 63115 |
| October 26, 2005 – 20.30 | Lecce | Home | Won 3-0 | 27084 |