2010–11 UEFA Champions League Second qualifying round Second qualifying round

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Liepājas Metalurgs | 0–5 | Sparta Prague | 0–3 | 0–2 |
| Aktobe | 3–1 | Olimpi Rustavi | 2–0 | 1–1 |
| Levadia | 3–4 | Debrecen | 1–1 | 2–3 |
| Partizan | 4–1 | Pyunik | 3–1 | 1–0 |
| Inter Baku | 1–1 (8–9 p ) | Lech Poznań | 0–1 | 1–0 ( aet ) |
| Dinamo Zagreb | 5–4 | Koper | 5–1 | 0–3 |
| Litex Lovech | 5–0 | Rudar Pljevlja | 1–0 | 4–0 |
| Birkirkara | 1–3 | Žilina | 1–0 | 0–3 |
| Sheriff Tiraspol | 3–2 | Dinamo Tirana | 3–1 | 0–1 |
| Hapoel Tel Aviv | 6–0 | Željezničar | 5–0 | 1–0 |
| Omonia | 5–0 | Renova | 3–0 | 2–0 |
| Red Bull Salzburg | 5–1 | HB Tórshavn | 5–0 | 0–1 |
| Bohemians | 1–4 | The New Saints | 1–0 | 0–4 |
| BATE | 6–1 | FH | 5–1 | 1–0 |
| AIK | 1–0 | Jeunesse Esch | 1–0 | 0–0 |