1981 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 6, 1981 | New York Jets | W 31–0 | 79754 |
| 2 | September 13, 1981 | at Baltimore Colts | W 35–3 | 44950 |
| 3 | September 17, 1981 | Philadelphia Eagles | L 20–14 | 78331 |
| 4 | September 27, 1981 | at Cincinnati Bengals | L 27–24 | 46418 |
| 5 | October 4, 1981 | Baltimore Colts | W 23–17 | 77811 |
| 6 | October 12, 1981 | Miami Dolphins | W 31–21 | 78576 |
| 7 | October 18, 1981 | at New York Jets | L 33–14 | 54607 |
| 8 | October 25, 1981 | Denver Broncos | W 9–7 | 77757 |
| 9 | November 1, 1981 | Cleveland Browns | W 22–13 | 78266 |
| 10 | November 9, 1981 | at Dallas Cowboys | L 27–14 | 62583 |