2000–01 Middlesbrough F.C. season FA Premier League FA Premier League

| Date_ | Opponent | Venue | Result_ | Attendance |
|---|---|---|---|---|
| 10 February 2001 | Aston Villa | A | 1–1 | 28912 |
| 24 February 2001 | Southampton | H | 0–1 | 28725 |
| 3 March 2001 | Charlton Athletic | H | 0–0 | 28177 |
| 17 March 2001 | Newcastle United | A | 2–1 | 51751 |
| 31 March 2001 | Chelsea | A | 1–2 | 34933 |
| 9 April 2001 | Sunderland | H | 0–0 | 31284 |
| 14 April 2001 | Arsenal | A | 3–0 | 37879 |
| 16 April 2001 | Ipswich Town | H | 1–2 | 34294 |
| 21 April 2001 | Leicester City | A | 3–0 | 18162 |
| 28 April 2001 | Manchester United | H | 0–2 | 34417 |
| 5 May 2001 | Bradford City | A | 1–1 | 20921 |
| 19 May 2001 | West Ham United | H | 2–1 | 33057 |