2008 Chicago White Sox season Game log April

| Date_ | Opponent | Score | Loss | Time_ | Att_ | Record |
|---|---|---|---|---|---|---|
| April 10 | Twins | Postponed (rain), rescheduled for June 9 | Postponed (rain), rescheduled for June 9 | Postponed (rain), rescheduled for June 9 | Postponed (rain), rescheduled for June 9 | Postponed (rain), rescheduled for June 9 |
| April 11 | Tigers | 2–5 | Contreras (0–1) | 3:13 | 26094 | 5–4 |
| April 12 | Tigers | 7–0 | Verlander (0–2) | 2:25 | 29649 | 6–4 |
| April 13 | Tigers | 11–0 | Rogers (0–3) | 2:34 | 26294 | 7–4 |
| April 14 | Athletics | 1–2 | Buehrle (1–1) | 2:40 | 20430 | 7–5 |
| April 15 | Athletics | 4–1 | Eveland (1–1) | 2:18 | 18254 | 8–5 |
| April 16 | @ Orioles | 3–1 | Loewen (0–1) | 2:25 | 12080 | 9–5 |
| April 17 | @ Orioles | 5 – 6 (10) | Logan (1–1) | 3:20 | 13676 | 9–6 |
| April 18 | @ Rays | 9–2 | Niemann (1–1) | 3:02 | 12379 | 10–6 |
| April 19 | @ Rays | 0–5 | Buehrle (1–2) | 2:02 | 17613 | 10–7 |
| April 20 | @ Rays | 6–0 | Jackson (2–2) | 2:34 | 17212 | 11–7 |