2008 Arizona Diamondbacks season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 22 | Giants | 5 - 4 | Zito (0-5) | 25074 | 15-5 |
| April 23 | @ Dodgers | 8 - 3 | Haren (3-1) | 42590 | 15-6 |
| April 24 | @ Dodgers | 6 - 4 | Billingsley (0-4) | 38350 | 16-6 |
| April 25 | @ Padres | 5 - 1 | Wolf (2-1) | 31340 | 17-6 |
| April 26 | @ Padres | 8 - 7 (13) | Petit (0-1) | 31295 | 17-7 |
| April 27 | @ Padres | 2 - 1 | Peavy (3-1) | 40074 | 18-7 |
| April 28 | Astros | 5 - 3 | Sampson (1-3) | 19868 | 19-7 |
| April 29 | Astros | 6 - 4 | González (1-2) | 20241 | 19-8 |
| April 30 | Astros | 8 - 7 | Borkowski (0-2) | 21519 | 20-8 |