List of Houston Astros Opening Day starting pitchers Pitchers Pitchers

| Season | Pitcher | Decision | Final_score | Opponent | Location_ |
|---|---|---|---|---|---|
| 1962 | Bobby Shantz | W | 11–2 | Chicago Cubs | Colt Stadium |
| 1963 | Turk Farrell | L | 2–9 | San Francisco Giants | Colt Stadium |
| 1964 | Ken Johnson | W | 6–3 | Cincinnati Reds | Crosley Field |
| 1965 | Bob Bruce | L | 0–2 | Philadelphia Phillies | Astrodome |
| 1966 | Robin Roberts | L | 2–3 | Los Angeles Dodgers | Dodger Stadium |
| 1967 | Mike Cuellar | W | 6–1 | Atlanta Braves | Astrodome |
| 1968 | Larry Dierker | W | 5–4 | Pittsburgh Pirates | Astrodome |
| 1969 | Don Wilson | L | 1–2 | San Diego Padres | San Diego Stadium |
| 1970 | Larry Dierker (2) | W | 8–5 | San Francisco Giants | Candlestick Park |
| 1971 | Larry Dierker (3) | W | 5–2 | Los Angeles Dodgers | Astrodome |