2009–10 UEFA Europa League Second qualifying round Second qualifying round

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Rapid Wien | 8–0 | Vllaznia | 5–0 | 3–0 |
| Naftan | 2–2 ( a ) | Gent | 2–1 | 0–1 |
| Liepājas Metalurgs | 3–4 | Dinamo Tbilisi | 2–1 | 1–3 |
| Differdange | 1–3 | Rijeka | 1–0 | 0–3 |
| Sūduva | 1–2 | Randers | 0–1 | 1–1 |
| Vėtra | 3–2 | HJK Helsinki | 0–1 | 3–1 |
| Milano | 2–12 | Slaven Belupo | 0–4 | 2–8 |
| Dinamo Minsk | 1–4 | Tromsø | 0–0 | 1–4 |
| KR | 3–1 | Larissa | 2–0 | 1–1 |
| Brøndby | 4–2 | Flora | 0–1 | 4–1 |
| Aalborg BK | 1–3 | Slavija | 0–0 | 1–3 |
| Steaua Bucureşti | 4–1 | Újpest | 2–0 | 2–1 |
| Metalurh Donetsk | 5–1 | MTZ-RIPO Minsk | 3–0 | 2–1 |
| Crusaders | 3–5 † | Rabotnički | 1–1 | 2–4 |
| Bnei Yehuda | 5–0 | Dinaburg | 4–0 | 1–0 |
| NAC Breda | 8–0 | Gandzasar | 6–0 | 2–0 |
| Cherno More | 4–0 | Iskra-Stal | 1–0 | 3–0 |