Club Santos Laguna Most Appearances Most Appearances

| Player | Period | League | Concacaf | Libertadores | Merconorte | InterLiga | Superliga | Matches |
|---|---|---|---|---|---|---|---|---|
| Vicente Matías Vuoso | 2003 – 2006 / 2007 – 2010 | 226 | 7 | 8 | 0 | 10 | 6 | 257 |
| Adrián Martínez | 1998 – 2003 / 2004 – 2005 | 223 | 4 | 8 | 8 | 3 | 0 | 246 |