2008 New York Giants season Regular season Regular season

| Week | Date_ | Time_ | Opponent | Result_ | Game_site | Record |
|---|---|---|---|---|---|---|
| 1 | September 4, 2008 | 7:00 P.M. | Washington Redskins | W 16–7 | Giants Stadium | 1–0 |
| 2 | September 14, 2008 | 1:00 P.M. | at St. Louis Rams | W 41–13 | Edward Jones Dome | 2–0 |
| 3 | September 21, 2008 | 1:00 P.M. | Cincinnati Bengals | W 26–23 OT | Giants Stadium | 3–0 |
| 4 | Bye week | Bye week | Bye week | Bye week | Bye week | Bye week |
| 5 | October 5, 2008 | 1:00 P.M. | Seattle Seahawks | W 44–6 | Giants Stadium | 4–0 |
| 6 | October 13, 2008 | 8:30 P.M. | at Cleveland Browns | L 35–14 | Cleveland Browns Stadium | 4–1 |
| 7 | October 19, 2008 | 1:00 P.M. | San Francisco 49ers | W 29–17 | Giants Stadium | 5–1 |