List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation

| Year_ | City | State_province_dept_etc_ | Country | Notes_ |
|---|---|---|---|---|
| 1591 | Juan Aldama | Zacatecas | Mexico |  |
| 1591 | Paudalho | Pernambuco | Brazil |  |
| 1593 | San Salvador de Jujuy | Jujuy | Argentina |  |
| 1594 | Pinos | Zacatecas | Mexico |  |
| 1594 | San Luis | San Luis | Argentina |  |
| 1596 | Monterrey | Nuevo León | Mexico |  |
| 1596 | Villahermosa | Tabasco | Mexico | Originally called Villa Felipe II. |
| 1597 | Portobelo | Colón | Panama |  |
| 1598 | Parras | Coahuila | Mexico |  |
| 1599 | Natal | Rio Grande do Norte | Brazil |  |
| 1599 | Tadoussac | Quebec | Canada | Oldest continuously inhabited French established settlement in the Americas, oldest European established settlement in Quebec. |
| 1602 | David | Chiriquí Province | Panama |  |
| 1603 | Salamanca | Guanajuato | Mexico |  |
| 1604 | Port Royal | Nova Scotia | Canada | Oldest continuously inhabited European established settlement in Nova Scotia. |
| 1606 | Bayaguana | Monte Plata | Dominican Republic |  |