Lufthansa destinations Destinations Destinations

| City | Country | IATA | ICAO | Airport |
|---|---|---|---|---|
| Sal | Cape Verde | SID | GVAC | Amilcar Cabral Airport |
| Samara | Russia | KUF | UWWW | Kurumoch Airport |
| San Francisco | United States | SFO | KSFO | San Francisco Airport |
| San Juan | Puerto Rico | SJU | TJSJ | Luis Muñoz Marin Airport |
| Santiago | Chile | SCL | SCEL | Arturo Benitez Airport |
| São Paulo | Brazil | GRU | SBGR | Guarulhos Airport |
| Sarajevo | Bosnia and Herzegovina | SJJ | LQSA | Butmir Airport |
| Sármellék | Hungary | HUN | LHSM | Sármellék Airport |
| Seattle | United States | SEA | KSEA | Seattle–Tacoma Airport |
| Seoul | South Korea | ICN | RKSI | Incheon Airport |
| Shanghai | China | PVG | ZSPD | Pudong Airport |
| Shenyang | China | SHE | ZYTX | Taoxian Airport |
| Sibiu | Romania | SBZ | LRSB | Sibiu Airport |
| Singapore | Singapore | SIN | WSSS | Changi Airport |
| Sochi begins 2014-02-01 | Russia | AER | URSS | Adler-Sochi International Airport |