1980 San Diego Chargers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 7, 1980 | at Seattle Seahawks | W 34-13 | 62042 |
| 2 | September 14, 1980 | Oakland Raiders | W 30-24 | 51943 |
| 3 | September 21, 1980 | at Denver Broncos | W 30-13 | 74970 |
| 4 | September 28, 1980 | at Kansas City Chiefs | W 24-7 | 45161 |
| 5 | October 5, 1980 | Buffalo Bills | L 26-24 | 51982 |
| 6 | October 12, 1980 | at Oakland Raiders | L 38-24 | 44826 |
| 7 | October 19, 1980 | New York Giants | W 44-7 | 50397 |
| 8 | October 26, 1980 | at Dallas Cowboys | L 42-31 | 60639 |
| 9 | November 2, 1980 | at Cincinnati Bengals | W 31-14 | 46406 |
| 10 | November 9, 1980 | Denver Broncos | L 20-13 | 51435 |