1981 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 11 | November 15, 1981 | at St. Louis Cardinals | L 24–0 | 46214 |
| 12 | November 22, 1981 | New England Patrios | W 20–17 | 71593 |
| 13 | November 29, 1981 | Washington Redskins | W 21–14 | 59624 |
| 14 | December 6, 1981 | San Diego Chargers | W 28–27 | 51488 |
| 15 | December 13, 1981 | at New England Patriots | W 19–10 | 42549 |
| 16 | December 19, 1981 | at Miami Dolphins | L 16–6 | 72596 |