2009–10 UEFA Europa League Round of 32 Round of 32

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Rubin Kazan | 3–0 | Hapoel Tel Aviv | 3–0 | 0–0 |
| Athletic Bilbao | 1–5 | Anderlecht | 1–1 | 0–4 |
| Copenhagen | 2–6 | Marseille | 1–3 | 1–3 |
| Panathinaikos | 6–4 | Roma | 3–2 | 3–2 |
| Atlético Madrid | 3–2 | Galatasaray | 1–1 | 2–1 |
| Ajax | 1–2 | Juventus | 1–2 | 0–0 |
| Club Brugge | 1–3 | Valencia | 1–0 | 0–3 ( aet ) |
| Fulham | 3–2 | Shakhtar Donetsk | 2–1 | 1–1 |
| Liverpool | 4–1 | Unirea Urziceni | 1–0 | 3–1 |
| Hamburg | 3–3 ( a ) | PSV Eindhoven | 1–0 | 2–3 |
| Villarreal | 3–6 | Wolfsburg | 2–2 | 1–4 |
| Standard Liège | 3–2 | Red Bull Salzburg | 3–2 | 0–0 |
| Twente | 2–4 | Werder Bremen | 1–0 | 1–4 |
| Lille | 3–2 | Fenerbahçe | 2–1 | 1–1 |
| Everton | 2–4 | Sporting CP | 2–1 | 0–3 |
| Hertha BSC | 1–5 | Benfica | 1–1 | 0–4 |