2005 Chicago White Sox season Game log May

| Date_ | Opponent | Score | Loss | Time_ | Att_ | Record |
|---|---|---|---|---|---|---|
| May 11 | @ Devil Rays | 5–2 | Brazelton (1–7) | 2:51 | 9414 | 25–9 |
| May 12 | Orioles | 3–2 | Chen (4–2) | 2:21 | 29031 | 26–9 |
| May 13 | Orioles | 5–3 | Williams (3–3) | 2:29 | 28188 | 27–9 |
| May 14 | Orioles | 6–9 | García (3–3) | 3:14 | 37311 | 27–10 |
| May 15 | Orioles | 2–6 | Contreras (1–1) | 3:00 | 34030 | 27–11 |
| May 16 | Rangers | 6–7 | Marte (2–3) | 3:01 | 26889 | 27–12 |
| May 17 | Rangers | 5–2 | Astacio (1–5) | 2:22 | 18333 | 28–12 |
| May 18 | Rangers | 7–0 | Drese (3–4) | 2:24 | 16255 | 29–12 |
| May 20 | @ Cubs | 5 – 1 (10) | Maddux (2–2) | 2:28 | 38988 | 30–12 |
| May 21 | @ Cubs | 5–3 | Wuertz (2–2) | 3:09 | 39461 | 31–12 |
| May 22 | @ Cubs | 3–4 | Vizcaíno (2–2) | 2:16 | 39334 | 31–13 |