2000–01 Macedonian Cup Eighth-finals Eighth-finals

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Sloga Jugomagnat | 2–1 | Pobeda | 2–0 | 0–1 |
| Pelister | ( a )5–5 | Sileks | 2–0 | 3–5 |
| Rabotnički | 3–3 (1–3 p ) | Škendija HB | 2–1 | 1–2 ( aet ) |
| Belasica | 7–1 | Bregalnica Štip | 6–0 | 1–1 |
| Karaorman | ( a )4–4 | Borec MHK | 3–0 | 1–4 |
| Vardar | 7–1 | Napredok | 5–1 | 2–0 |
| Alumina | 2–4 | Baškimi | 1–0 | 1–4 |
| Cementarnica | 8–0 | Madžari Solidarnost | 2–0 | 6–0 |