2010 US Open (tennis) Single seeds Women's singles

| Seed | Rank_ | Player | Points | Points_defending | Points_won | New_points | Status_ |
|---|---|---|---|---|---|---|---|
| 1 | 2 | Caroline Wozniacki | 6410 | 1400 | 900 | 5910 | Semifinals lost to Vera Zvonareva [7] |
| 3 | 4 | Venus Williams | 5176 | 280 | 900 | 5796 | Semifinals lost to Kim Clijsters [2] |
| 4 | 5 | Jelena Janković | 5145 | 100 | 160 | 5205 | 3rd round lost to Kaia Kanepi [31] |
| 5 | 6 | Samantha Stosur | 4550 | 100 | 500 | 4950 | Quarterfinals lost to Kim Clijsters [2] |
| 6 | 7 | Francesca Schiavone | 4450 | 280 | 500 | 4670 | Quarterfinals lost to Venus Williams [3] |
| 8 | 9 | Li Na | 4015 | 500 | 5 | 3520 | 1st round lost to Kateryna Bondarenko |
| 9 | 10 | Agnieszka Radwańska | 3995 | 100 | 100 | 3995 | 2nd round lost to Peng Shuai |