2000 Buffalo Bills season NFL Draft NFL Draft

| Round | Pick_ | Player | Position_ | College |
|---|---|---|---|---|
| 1 | 26 | Erik Flowers | Defensive End | Arizona State |
| 2 | 58 | Travares Tillman | Free Safety | Georgia Tech |
| 3 | 89 | Corey Moore | Linebacker | Virginia Tech |
| 4 | 121 | Avion Black | Wide Receiver | Tennessee State |
| 5 | 156 | Sammy Morris | Fullback | Texas Tech |
| 6 | 194 | Leif Larsen | Defensive End | Texas-El Paso (UTEP) |
| 7 | 233 | Drew Haddad | Wide Receiver | Buffalo |
| 7 | 251 | DaShon Polk | Linebacker | Arizona |