1960 Buffalo Bills season Season schedule Regular season

| Week | Date_ | Opponent | Result_ | Game_site | Attendance_ |
|---|---|---|---|---|---|
| 1 | September 11, 1960 | at New York Titans | L 27–3 | Polo Grounds | 10200 |
| 2 | September 18, 1960 | Denver Broncos | L 27–21 | War Memorial Stadium | 15229 |
| 3 | September 23, 1960 | at Boston Patriots | W 13–0 | Nickerson Field | 20732 |
| 4 | October 2, 1960 | Los Angeles Chargers | L 24–10 | War Memorial Stadium | 15821 |
| 6 | October 16, 1960 | New York Titans | L 17–13 | War Memorial Stadium | 14988 |
| 7 | October 23, 1960 | Oakland Raiders | W 38–9 | War Memorial Stadium | 8876 |
| 8 | October 30, 1960 | Houston Oilers | W 25–24 | War Memorial Stadium | 23001 |
| 9 | November 6, 1960 | Dallas Texans | L 45–28 | War Memorial Stadium | 19610 |