2005–06 U.S. Città di Palermo season Serie A Serie A

| Date_and_time | Opponent | Venue | Result_ | Attendance |
|---|---|---|---|---|
| January 18, 2006 – 20.30 | Parma | Home | Won 4-2 | 26990 |
| January 21, 2006 – 20.30 | Inter | Away | Lost 0-3 | 48942 |
| January 28, 2006 – 18.00 | Siena | Home | Lost 1-3 | 26428 |
| February 5, 2006 – 15.00 | Reggina | Away | Drew 2-2 | 13683 |
| February 8, 2006 – 20.30 | Lazio | Home | Won 3-1 | 27074 |
| February 12, 2006 – 15.00 | Empoli | Away | Won 1-0 | 5379 |
| February 19, 2006 – 15.00 | Chievo | Away | Drew 0-0 | 5580 |
| February 26, 2006 – 15.00 | AC Milan | Home | Lost 0-2 | 31868 |
| March 5, 2006 – 15.00 | Lecce | Away | Lost 0-2 | 10890 |
| March 12, 2006 – 15.00 | Udinese | Home | Won 2-0 | 25792 |