1965 Buffalo Bills season Season schedule Season schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 11, 1965 | Boston Patriots | W 24–7 | 45502 |
| 2 | September 19, 1965 | at Denver Broncos | W 30–15 | 30682 |
| 3 | September 26, 1965 | New York Jets | W 33–21 | 45056 |
| 4 | October 3, 1965 | Oakland Raiders | W 17–12 | 41256 |
| 5 | October 10, 1965 | San Diego Chargers | L 34–3 | 45260 |
| 6 | October 17, 1965 | at Kansas City Chiefs | W 23-7 | 26941 |
| 7 | October 24, 1965 | Denver Broncos | W 31-13 | 45046 |
| 8 | October 31, 1965 | Houston Oilers | L 19–17 | 44267 |
| 9 | November 7, 1965 | at Boston Patriots | W 23–7 | 24415 |
| 10 | November 14, 1965 | at Oakland Raiders | W 17–14 | 19352 |