2006 Toronto Blue Jays season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 4 | Twins | 6–3 | Santana (0–1) | 50449 | 1–0 |
| April 5 | Twins | 13–4 | Towers (0–1) | 18156 | 1–1 |
| April 6 | Twins | 6–3 | Silva (0–1) | 16221 | 2–1 |
| April 7 | Devil Rays | 9–8 | Walker (0–1) | 15631 | 2–2 |
| April 8 | Devil Rays | 8–4 | Childers (0–1) | 18755 | 3–2 |
| April 9 | Devil Rays | 5–2 | Halladay (1–1) | 20184 | 3–3 |
| April 11 | @ Red Sox | 5–3 | Towers (0–2) | 35491 | 3–4 |
| April 12 | @ Red Sox | 8–4 | Wells (0–1) | 36378 | 4–4 |
| April 13 | @ Red Sox | 8–6 | Clement (1–1) | 36524 | 5–4 |
| April 14 | @ White Sox | 13–7 | Vázquez (0–1) | 31418 | 6–4 |