2000 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Location_ | Record | Attendance |
|---|---|---|---|---|---|---|
| 16 | December 17, 2000 | New England Patriots | L 13–10 | Ralph Wilson Stadium | 7-8 | 47230 |
| 17 | December 23, 2000 | at Seattle Seahawks | W 42–23 | Husky Stadium | 8-8 | 61025 |