1980 African Cup of Champions Clubs Second round Second round

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Djoliba AC | 1-2 | Hearts of Oak | 1-1 | 0-1 |
| Etoile du Congo | 1-1 (3-1 pen) | Hafia FC | 0-1 | 1-0 |
| Simba SC | 2-5 | Union Douala | 2-4 | 0-1 |
| Silures | 0-4 | Canon Yaoundé | 0-1 | 0-3 |
| AC Semassi | 1-2 | ASF Police | 1-1 | 0-1 |
| Stella Club d`Adjamé | 5-5 | MP Algiers | 4-2 | 1-3 |
| Bendel Insurance | 4-4 | Gor Mahia | 1-2 | 3-2 |
| AS Bilima | 4-1 | Fortior Mahajanga | 3-0 | 1-1 |