1972 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Stadium | Result_ | Record | Streak | Attendance |
|---|---|---|---|---|---|---|---|
| 1 | Sept. 17 | New York Jets | War Memorial Stadium | L 41–24 | 0–1 | L1 | 46206 |
| 2 | Sept. 24 | San Francisco 49ers | War Memorial Stadium | W 27–20 | 1–1 | W1 | 45845 |
| 3 | Oct. 1 | Baltimore Colts | War Memorial Stadium | L 17–0 | 1–2 | L1 | 46206 |
| 4 | Oct. 8 | New England Patriots | War Memorial Stadium | W 38–14 | 2–2 | W1 | 41749 |
| 5 | Oct. 15 | at Oakland Raiders | Oakland-Alameda County Coliseum | L 28–16 | 2–3 | L1 | 53501 |
| 6 | Oct. 22 | at Miami Dolphins | Miami Orange Bowl | L 24–23 | 2–4 | L2 | 80010 |
| 7 | Oct. 29 | Pittsburgh Steelers | War Memorial Stadium | L 38–21 | 2–5 | L3 | 45882 |