1988 New England Patriots season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Record | Attendance |
|---|---|---|---|---|---|
| 1 | September 4, 1988 | New York Jets | W 28–3 | 1–0 | 44027 |
| 2 | September 11, 1988 | at Minnesota Vikings | L 36–6 | 1–1 | 55545 |
| 3 | September 18, 1988 | Buffalo Bills | L 16–14 | 1–2 | 55945 |
| 4 | September 25, 1988 | at Houston Oilers | L 31–6 | 1–3 | 38646 |
| 5 | October 2, 1988 | Indianapolis Colts | W 21–17 | 2–3 | 58050 |
| 6 | October 9, 1988 | at Green Bay Packers | L 45–3 | 2–4 | 51932 |
| 7 | October 16, 1988 | Cincinnati Bengals | W 27–21 | 3–4 | 59969 |
| 8 | October 23, 1988 | at Buffalo Bills | L 23–20 | 3–5 | 76824 |
| 9 | October 30, 1988 | Chicago Bears | W 30–7 | 4–5 | 60821 |