2005 Washington Nationals season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 14 | Arizona Diamondbacks | 5-3 | Vázquez (0-2) | 45596 | 6-4 |
| April 16 | Arizona Diamondbacks | 9-3 | Ortiz (1-1) | 34943 | 7-4 |
| April 17 | Arizona Diamondbacks | 7-3 | Koplove (1-1) | 35463 | 8-4 |
| April 18 | Florida Marlins | 4-9 | Ohka (1-2) | 24003 | 8-5 |
| April 19 | Florida Marlins | 3-6 | Hernández (1-2) | 25990 | 8-6 |
| April 20 | Atlanta Braves | 2-0 | Ramírez (1-1) | 27374 | 9-6 |
| April 21 | Atlanta Braves | 1-2 | Cordero (2-1) | 30728 | 9-7 |
| April 22 | @ New York Mets | 1-3 | Loaiza (0-1) | 28488 | 9-8 |
| April 23 | @ New York Mets | 5-10 | Ohka (1-3) | 44058 | 9-9 |
| April 24 | @ New York Mets | 11-4 | Zambrano (1-2) | 43313 | 10-9 |
| April 25 | Philadelphia Phillies | 4-5 | Day (1-2) | 24956 | 10-10 |