2010 US Open (tennis) Single seeds Women's singles

| Seed | Rank_ | Player | Points | Points_defending | Points_won | New_points | Status_ |
|---|---|---|---|---|---|---|---|
| 10 | 11 | Victoria Azarenka | 3775 | 160 | 100 | 3715 | 2nd round retired to Gisela Dulko |
| 11 | 12 | Svetlana Kuznetsova | 3516 | 280 | 280 | 3516 | 4th round lost to Dominika Cibulková |
| 12 | 13 | Elena Dementieva | 3765 | 100 | 280 | 3945 | 4th round lost to Samantha Stosur [5] |
| 13 | 15 | Marion Bartoli | 3455 | 100 | 100 | 3455 | 2nd round lost to Virginie Razzano |
| 14 | 16 | Maria Sharapova | 3330 | 160 | 280 | 3450 | 4th round lost to Caroline Wozniacki [1] |
| 15 | 17 | Yanina Wickmayer | 3310 | 900 | 280 | 2690 | 4th round lost to Kaia Kanepi [31] |
| 16 | 18 | Shahar Pe`er | 3175 | 160 | 280 | 3295 | 4th round lost to Venus Williams [3] |