2008 CAF Champions League First Round (1/16 Finals) First Round (1/16 Finals)

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Olympique Khouribga | 2–2 (3–0 p ) | ES Setif | 2–0 | 0–2 |
| ASEC Mimosas | 2–1 | AS Kaloum Star | 1–1 | 1–0 |
| Sporting Clube da Praia | 2–2 ( a ) | Inter Luanda | 2–1 | 0–1 |
| Al-Zamalek | 2–2 (5–4 p ) | Africa Sports National | 2–0 | 0–2 |
| Etoile du Sahel | 5–3 | AS Douanes | 5–0 | 0–3 |
| Dynamos | 4–2 | Costa do Sol | 3–0 | 1–2 |
| JS Kabylie | 3–0 | Ashanti Gold SC | 3–0 | 0–0 |
| Coton Sport FC | 6–2 | Gombe United F.C. | 5–0 | 1–2 |
| TP Mazembe | 2–1 | FC 105 Libreville | 1–1 | 1–0 |
| Al Ittihad Tripoli | ( a ) 2–2 | 1º de Agosto | 1–0 | 1–2 |
| ASKO Kara | 2–4 | Club Africain | 2–0 | 0–4 |