2010 East–West Shrine Game 2010 NFL Draft 2010 NFL Draft

| Round_ | Pick_ | NFL_Team | Player | Position_ | College |
|---|---|---|---|---|---|
| 4 | 122 | Philadelphia Eagles (from Green Bay) | Mike Kafka | Quarterback | Northwestern |
| 4 | 125 | Philadelphia Eagles (from Dallas) | Clay Harbor | Tight end | Missouri State |
| 4 | 130 | Arizona Cardinals (from New Orleans Saints) | O`Brien Schofield | Defensive end | Wisconsin |
| 5 | 147 | New York Giants | Mitch Petrus | Guard | Arkansas |
| 5 | 148 | Tennessee Titans | Robert Johnson | Safety | Utah |
| 5 | 151 | Pittsburgh Steelers | Chris Scott | Offensive tackle | Tennessee |
| 5 | 154 | Green Bay Packers | Andrew Quarless | Tight end | Penn State |
| 5 | 156 | Baltimore Ravens | David Reed | Wide receiver | Utah |
| 5 | 161 | Minnesota Vikings | Chris DeGeare | Offensive tackle | Wake Forest |
| 5 | 165 | Atlanta Falcons | Kerry Meier | Wide receiver | Kansas |
| 5 | 166 | Pittsburgh Steelers | Stevenson Sylvester | Linebacker | Utah |