1988 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Record | Game_Site | Attendance |
|---|---|---|---|---|---|---|
| 1 | September 4, 1988 | Minnesota Vikings | W 13–10 | 1–0 | Rich Stadium | 76783 |
| 2 | September 11, 1988 | Miami Dolphins | W 9–6 | 2–0 | Rich Stadium | 79520 |
| 3 | September 18, 1988 | at New England Patriots | W 16–14 | 3–0 | Sullivan Stadium | 55945 |
| 4 | September 25, 1988 | Pittsburgh Steelers | W 36–28 | 4–0 | Rich Stadium | 78735 |
| 5 | October 2, 1988 | at Chicago Bears | L 24–3 | 4–1 | Soldier Field | 62793 |
| 6 | October 9, 1988 | Indianapolis Colts | W 34–23 | 5–1 | Rich Stadium | 76018 |
| 7 | October 17, 1988 | at New York Jets | W 37–14 | 6–1 | The Meadowlands | 70218 |