1968 Buffalo Bills season Season schedule Season schedule

| Date_ | Opponent | Score | Result_ | Record | Attendance |
|---|---|---|---|---|---|
| September 8 | Boston Patriots | 16-7 | Loss | 0–1 | 38865 |
| September 15 | Oakland Raiders | 48–6 | Loss | 0–2 | 43056 |
| September 22 | at Cincinnati Bengals | 34-23 | Loss | 0–3 | 24405 |
| September 29 | New York Jets | 37-35 | Win | 1–3 | 38044 |
| October 5 | Kansas City Chiefs | 18-7 | Loss | 1–4 | 40748 |
| October 12 | at Miami Dolphins | 14-14 | Tie | 1-4-1 | 28559 |
| October 20 | at Boston Patriots | 23-6 | Loss | 1-5-1 | 21082 |
| October 27 | Houston Oilers | 30-7 | Loss | 1-6-1 | 34339 |
| November 3 | at New York Jets | 25-21 | Loss | 1-7-1 | 61452 |
| November 10 | Miami Dolphins | 21-17 | Loss | 1–8-1 | 28751 |
| November 17 | San Diego Chargers | 21-6 | Loss | 1-9-1 | 27993 |