1980–81 FA Cup Fourth Round Proper Fourth Round Proper

| Tie_no | Home_team | Score | Away_team | Date_ |
|---|---|---|---|---|
| 1 | Southampton | 3–1 | Bristol Rovers | 24 January 1981 |
| 2 | Watford | 1–1 | Wolverhampton Wanderers | 24 January 1981 |
| Replay | Wolverhampton Wanderers | 2–1 | Watford | 27 January 1981 |
| 3 | Leicester City | 1–1 | Exeter City | 24 January 1981 |
| Replay | Exeter City | 3–1 | Leicester City | 28 January 1981 |
| 4 | Notts County | 0–1 | Peterborough United | 24 January 1981 |
| 5 | Nottingham Forest | 1–0 | Manchester United | 24 January 1981 |
| 6 | Middlesbrough | 1–0 | West Bromwich Albion | 24 January 1981 |
| 7 | Everton | 2–1 | Liverpool | 24 January 1981 |
| 8 | Shrewsbury Town | 0–0 | Ipswich Town | 24 January 1981 |
| Replay | Ipswich Town | 3–0 | Shrewsbury Town | 27 January 1981 |