2000 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Location_ | Record | Attendance |
|---|---|---|---|---|---|---|
| 8 | October 22, 2000 | at Minnesota Vikings | L 31–27 | Hubert H. Humphrey Metrodome | 3-4 | 64116 |
| 9 | October 29, 2000 | New York Jets | W 23–20 | Ralph Wilson Stadium | 4-4 | 72861 |
| 10 | November 5, 2000 | at New England Patriots | W 16–13 | Foxboro Stadium | 5-4 | 60292 |
| 11 | November 12, 2000 | Chicago Bears | W 20–3 | Ralph Wilson Stadium | 6-4 | 72420 |
| 12 | November 19, 2000 | at Kansas City Chiefs | W 21–17 | Arrowhead Stadium | 7-4 | 78457 |
| 13 | November 26, 2000 | at Tampa Bay Buccaneers | L 31–17 | Raymond James Stadium | 7-5 | 65546 |
| 14 | December 3, 2000 | Miami Dolphins | L 33–6 | Ralph Wilson Stadium | 7-6 | 73002 |
| 15 | December 11, 2000 | at Indianapolis Colts | L 44–20 | RCA Dome | 7-7 | 56671 |