2000 Cleveland Indians season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 12 | Red Sox | 8 - 6 | Finley (12-11) | 42714 | 76-64 |
| September 13 | Red Sox | 10 - 3 | Ohka (3-5) | 42667 | 77-64 |
| September 14 | Red Sox | 7 - 4 | Nagy (2-5) | 42709 | 77-65 |
| September 15 | @ Yankees | 11 - 1 | Cone (4-12) | 48443 | 78-65 |
| September 16 | @ Yankees | 6 - 3 | Bere (5-3) | 55097 | 78-66 |
| September 17 | @ Yankees | 15 - 4 | Neagle (7-5) | 50174 | 79-66 |
| September 18 | @ Yankees | 2 - 0 | Clemens (13-7) | 31317 | 80-66 |
| September 19 | @ Red Sox | 7 - 4 | Nagy (2-6) | 32512 | 80-67 |
| September 20 | @ Red Sox | 2 - 1 | Martínez (17-6) | 33002 | 81-67 |