2000 New England Patriots season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 3, 2000 | Tampa Bay Buccaneers | L 21–16 | 60292 |
| 2 | September 11, 2000 | at New York Jets | L 20–19 | 77687 |
| 3 | September 17, 2000 | Minnesota Vikings | L 21–13 | 59835 |
| 4 | September 24, 2000 | at Miami Dolphins | L 10–3 | 73344 |
| 5 | October 1, 2000 | at Denver Broncos | W 28–19 | 75684 |
| 6 | October 8, 2000 | Indianapolis Colts | W 24–16 | 60292 |
| 7 | October 15, 2000 | New York Jets | L 34–17 | 60292 |
| 8 | October 22, 2000 | at Indianapolis Colts | L 30–23 | 56828 |
| 9 | Bye | Bye | Bye | Bye |
| 10 | November 5, 2000 | Buffalo Bills | L 16–13 | 60292 |