Mike Bryan Doubles: 25 (15–10) Doubles: 25 (15–10)

| Outcome | Year_ | Championship | Surface | Partner | Opponents | Score |
|---|---|---|---|---|---|---|
| Winner | 2005 | US Open | Hard | Bob Bryan | Jonas Björkman Max Mirnyi | 6–1, 6–4 |
| Winner | 2006 | Australian Open | Hard | Bob Bryan | Martin Damm Leander Paes | 4–6, 6–3, 6–4 |
| Runner-up | 2006 | French Open | Clay | Bob Bryan | Jonas Björkman Max Mirnyi | 7–6 (7–5) , 4–6, 5–7 |
| Winner | 2006 | Wimbledon | Grass | Bob Bryan | Fabrice Santoro Nenad Zimonjić | 6–4, 4–6, 6–4, 6–2 |
| Winner | 2007 | Australian Open | Hard | Bob Bryan | Jonas Björkman Max Mirnyi | 7–5, 7–5 |
| Runner-up | 2007 | Wimbledon | Grass | Bob Bryan | Arnaud Clément Michaël Llodra | 7–6 (7–5) , 3–6, 4–6, 4–6 |
| Winner | 2008 | US Open | Hard | Bob Bryan | Lukáš Dlouhý Leander Paes | 7–6 (7–5) , 7–6 (12–10) |