2010 NHL Entry Draft Round two Round two

| Pick_ | Player | Nationality | Position_ | Team_from | League_from |
|---|---|---|---|---|---|
| 39 | Brett Bulmer | Canada | RW | Kelowna Rockets | Western Hockey League |
| 40 | Christian Thomas | Canada | RW | Oshawa Generals | Ontario Hockey League |
| 41 | Patrik Nemeth | Sweden | D | AIK | J20 SuperElit (Sweden) |
| 42 | Devante Smith-Pelly | Canada | RW | Mississauga St. Michael`s Majors | Ontario Hockey League |
| 43 | Bradley Ross | Canada | LW | Portland Winterhawks | Western Hockey League |
| 44 | Sebastian Wannstrom | Sweden | C | Brynäs IF | J20 SuperElit (Sweden) |
| 45 | Ryan Spooner | Canada | C | Peterborough Petes | Ontario Hockey League |
| 46 | Martin Marincin | Slovakia | D | HC Košice | Slovak Extraliga |
| 47 | Tyler Toffoli | Canada | RW | Ottawa 67`s | Ontario Hockey League |
| 48 | Curtis Hamilton | Canada | LW | Saskatoon Blades | Western Hockey League |
| 49 | Calvin Pickard | Canada | G | Seattle Thunderbirds | Western Hockey League |