1981 Atlanta Falcons season Regular season Schedule

| Week | Date_ | Opponent | Result_ | Attendance_ |
|---|---|---|---|---|
| 1 | September 6, 1981 | New Orleans Saints | W 27–0 | 57406 |
| 2 | September 13, 1981 | at Green Bay Packers | W 31–17 | 55382 |
| 3 | September 20, 1981 | San Francisco 49ers | W 34–17 | 56653 |
| 4 | September 27, 1981 | at Cleveland Browns | L 28–17 | 78283 |
| 5 | October 5, 1981 | at Philadelphia Eagles | L 16–13 | 71488 |
| 6 | October 11, 1981 | Los Angeles Rams | L 37–35 | 57841 |
| 7 | October 18, 1981 | St. Louis Cardinals | W 41–20 | 51428 |
| 8 | October 25, 1981 | New York Giants | L 27–24 | 48410 |
| 9 | November 1, 1981 | at New Orleans Saints | W 41–10 | 63637 |