2008 Tennessee Titans season Regular season Regular season

| Week | Date_ | Opponent | Result_ | Game_site | Record |
|---|---|---|---|---|---|
| 10 | November 9 | at Chicago Bears | W 21–14 | Soldier Field | 9–0 |
| 11 | November 16 | at Jacksonville Jaguars | W 24–14 | Jacksonville Municipal Stadium | 10–0 |
| 12 | November 23 | New York Jets | L 13-34 | LP Field | 10–1 |
| 13 | November 27 | at Detroit Lions | W 47–10 | Ford Field | 11–1 |
| 14 | December 7 | Cleveland Browns | W 28–9 | LP Field | 12–1 |
| 15 | December 14 | at Houston Texans | L 12-13 | Reliant Stadium | 12–2 |
| 16 | December 21 | Pittsburgh Steelers | W 31–14 | LP Field | 13–2 |
| 17 | December 28 | at Indianapolis Colts | L 0-23 | Lucas Oil Stadium | 13–3 |