Oncogene Classification Classification

| Category | Examples | Cancers | Gene_functions_ |
|---|---|---|---|
| Cytoplasmic tyrosine kinases | Src-family, Syk-ZAP-70 family, and BTK family of tyrosine kinases, the Abl gene in CML - Philadelphia chromosome | colorectal and breast cancers, melanomas, ovarian cancers, gastric cancers, head and neck cancers, pancreatice cancer, lung cancer, brain cancers, and blood cancers | mediate the responses to, and the activation receptors of cell proliferation, migration, differentiation, and survival |
| Cytoplasmic Serine/threonine kinases and their regulatory subunits | Raf kinase, and cyclin-dependent kinases (through overexpression). | malignant melanoma, papillary thyroid cancer, colorectal cancer, and ovarian cancer | Involved in organism development, cell cycle regulation, cell proliferation, differentiation, cells survival, and apoptosis |
| Regulatory GTPases | Ras protein | adenocarcinomas of the pancreas and colon, thyroid tumors, and myeloid leukemia | involved in signalling a major pathway leading to cell proliferation. |
| Transcription factors | myc gene | malignant T-cell lymphomas and acute myleoid leukemias, breast cancer, pancreatic cancer, retinoblastoma, and small cell lung cancer | -They regulate transcription of genes that induce cell proliferation. |