1968 San Francisco 49ers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 15, 1968 | at Baltimore Colts | L 27-10 | 56864 |
| 2 | September 22, 1968 | St. Louis Cardinals | W 35-17 | 27557 |
| 3 | September 29, 1968 | Atlanta Falcons | W 28-13 | 27477 |
| 4 | October 6, 1968 | at Los Angeles Rams | L 24-10 | 69520 |
| 5 | October 13, 1968 | Baltimore Colts | L 42-14 | 32822 |
| 6 | October 20, 1968 | at New York Giants | W 26-10 | 62958 |
| 7 | October 27, 1968 | at Detroit Lions | W 14-7 | 53555 |
| 8 | November 3, 1968 | Cleveland Browns | L 33-21 | 31359 |
| 9 | November 10, 1968 | at Chicago Bears | L 27-19 | 46978 |
| 10 | November 17, 1968 | Los Angeles Rams | T 20-20 | 41815 |