5th United States Congress Senate Senate

| State_class | Vacator | Reason_for_change | Successor | Date_of_successors_formal_installation |
|---|---|---|---|---|
| Vermont (1) | Isaac Tichenor ( F ) | Resigned October 17, 1797 | Nathaniel Chipman ( F ) | Elected October 17, 1797 |
| Maryland (3) | John Henry ( F ) | Resigned December 10, 1797 | James Lloyd ( F ) | Elected December 11, 1797 |
| New York (1) | Philip John Schuyler ( F ) | Resigned January 3, 1798 | John Sloss Hobart ( F ) | Elected January 11, 1798 |
| Delaware (2) | John Vining ( F ) | Resigned January 19, 1798 | Joshua Clayton ( F ) | Elected January 19, 1798 |
| Tennessee (1) | Andrew Jackson ( DR ) | Resigned sometime in April, 1798 | Daniel Smith ( DR ) | Appointed October 6, 1798 |