List of highway route numbers in Oregon Mainline routes Mainline routes

| Number_ | South_west_end | North_east_end | Formed | Eliminated_ |
|---|---|---|---|---|
| U.S. Route 99W | OR 99/OR 99E in Junction City | OR 99/OR 99E in Portland | 1928 | 1972 |
| U.S. Route 199 | US 199 towards Crescent City, CA | I-5/OR 99 in Grants Pass | 1926 |  |
| U.S. Route 101 | US 101 towards Crescent City, CA | US 101 towards Aberdeen, WA | 1926 |  |
| U.S. Route 101 Business | US 101 in Warrenton | US 101 in Astoria | 1967 |  |
| Oregon Route 2 | US 101 south of Seaside | OR 10 in Portland | 1932 | 1952 |
| Oregon Route 3 | OR 82 in Enterprise | WA 129 towards Clarkston, WA | 1932 |  |
| Oregon Route 6 | US 101/OR 131 in Tillamook | US 26 west of North Plains | 1932 |  |
| Oregon Route 7 | US 26 south of Austin | I-84 in Baker | 1932 |  |