John Isner Wins over top-10 players per season Wins over top-10 players per season

| Player | Rank_ | Event | Surface | Score |
|---|---|---|---|---|
| 2009 | 2009 | 2009 | 2009 | 2009 |
| Gaël Monfils | 9 | Indian Wells , United States | Hard | 6–7 (5–7) , 6–1, 6–4 |
| Jo-Wilfried Tsonga | 7 | Washington , United States | Hard | 4–6, 7–6 (7–2) , 7–6 (7–4) |
| Andy Roddick | 5 | US Open , New York, United States | Hard | 7–6 (7–3) , 6–3, 3–6, 5–7, 7–6 (7–5) |
| 2010 | 2010 | 2010 | 2010 | 2010 |
| Nikolay Davydenko | 6 | Beijing , China | Hard | 7–6 (7–2) , 6–4 |
| 2011 | 2011 | 2011 | 2011 | 2011 |
| David Ferrer | 5 | Paris , France | Hard (i) | 6–3, 3–6, 6–3 |
| 2012 | 2012 | 2012 | 2012 | 2012 |