2008 Seattle Mariners season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 20 | @ Angels | 4 - 2 | Moseley (1-2) | 43631 | 10-10 |
| April 22 | Orioles | 4 - 2 | Guthrie (0-2) | 17780 | 11-10 |
| April 23 | Orioles | 3 - 2 | Rowland-Smith (0-1) | 16823 | 11-11 |
| April 24 | Orioles | 8 - 7 | Green (1-1) | 16727 | 11-12 |
| April 25 | Athletics | 4 - 3 | Batista (2-3) | 40845 | 11-13 |
| April 26 | Athletics | 5 - 3 | Duchscherer (1-1) | 37563 | 12-13 |
| April 27 | Athletics | 4 - 2 | Hernández (2-1) | 32612 | 12-14 |
| April 29 | @ Indians | 7 - 2 | Betancourt (1-1) | 13827 | 13-14 |
| April 30 | @ Indians | 8 - 3 | Washburn (1-4) | 15279 | 13-15 |