John Isner Singles performance timeline Singles performance timeline

| Tournament | _2007 | _2008 | _2009 | _2010 | _2011 | _2012 |
|---|---|---|---|---|---|---|
| Grand Slam Tournaments | Grand Slam Tournaments | Grand Slam Tournaments | Grand Slam Tournaments | Grand Slam Tournaments | Grand Slam Tournaments | Grand Slam Tournaments |
| Australian Open | A | 1R | 1R | 4R | 3R | 3R |
| French Open | A | 1R | A | 3R | 1R | 2R |
| Wimbledon | A | 1R | A | 2R | 2R | 1R |
| US Open | 3R | 1R | 4R | 3R | QF | 3R |
| Win–Loss | 2–1 | 0–4 | 3–2 | 8–4 | 7–4 | 5–4 |
| Olympic Games | Olympic Games | Olympic Games | Olympic Games | Olympic Games | Olympic Games | Olympic Games |
| Summer Olympics | NH | A | Not Held | Not Held | Not Held | QF |