2010 East–West Shrine Game 2010 NFL Draft 2010 NFL Draft

| Round_ | Pick_ | NFL_Team | Player | Position_ | College |
|---|---|---|---|---|---|
| 5 | 169 | Green Bay Packers | Marshall Newhouse | Offensive tackle | TCU |
| 6 | 175 | Carolina Panthers (from Oakland) | Greg Hardy | Defensive end | Ole Miss |
| 6 | 182 | San Francisco 49ers | Nate Byham | Tight end | Pittsburgh |
| 6 | 187 | Houston Texans | Shelley Smith | Guard | Colorado State |
| 6 | 196 | Dallas Cowboys | Jamar Wall | Cornerback | Texas Tech |
| 7 | 212 | Miami Dolphins (from Kansas City) | Chris McCoy | Linebacker | Middle Tennessee |
| 7 | 213 | Detroit Lions (from Seattle) | Willie Young | Defensive end | North Carolina State |
| 7 | 216 | Buffalo Bills | Kyle Calloway | Offensive tackle | Iowa |
| 7 | 219 | Washington Redskins (from Miami) | Terrence Austin | Wide receiver | UCLA |
| 7 | 228 | Cincinnati Bengals | Reggie Stephens | Guard | Iowa State |
| 7 | 240 | Indianapolis Colts | Kavell Conner | Linebacker | Clemson |