List of Houston Astros Opening Day starting pitchers Pitchers Pitchers

| Season | Pitcher | Decision | Final_score | Opponent | Location_ |
|---|---|---|---|---|---|
| 2004* | Roy Oswalt (2) | ND (L) | 4–5 | San Francisco Giants | Minute Maid Park |
| 2005** | Roy Oswalt (3) | L | 3–7 | St. Louis Cardinals | Minute Maid Park |
| 2006 | Roy Oswalt (4) | W | 1–0 | Florida Marlins | Minute Maid Park |
| 2007 | Roy Oswalt (5) | ND (L) | 2–4 | Pittsburgh Pirates | Minute Maid Park |
| 2008 | Roy Oswalt (6) | L | 0–4 | San Diego Padres | Petco Park |
| 2009 | Roy Oswalt (7) | L | 2–4 | Chicago Cubs | Minute Maid Park |
| 2010 | Roy Oswalt (8) | L | 2–5 | San Francisco Giants | Minute Maid Park |
| 2011 | Brett Myers | ND (L) | 4–5 | Philadelphia Phillies | Citizens Bank Park |
| 2012 | Wandy Rodriguez | ND (L) | 4–5 | Colorado Rockies | Minute Maid Park |
| 2013 | Bud Norris | W | 8–2 | Texas Rangers | Minute Maid Park |