2010 Campeonato Brasileiro Série A Managerial changes Managerial changes

| Team | Outgoing_manager | Manner_of_departure | Date_of_vacancy | Position_in_table | Replaced_by | Date_of_appointment |
|---|---|---|---|---|---|---|
| Vasco da Gama | Vágner Mancini | Sacked | March 25 | Pre-season | Gaúcho (caretaker) | March 26 |
| Goiás | Jorginho | Sacked | April 19 | Pre-season | Émerson Leão | April 24 |
| Flamengo | Andrade | Sacked | April 23 | Pre-season | Rogério Lourenço | April 24 |
| Palmeiras | Antônio Carlos Zago | Sacked | May 18 | 7th | Jorge Parraga (caretaker) | May 19 |
| Vasco da Gama | Gaúcho (caretaker) | Replaced | May 18 | 16th | Celso Roth | May 18 |
| Atlético Paranaense | Leandro Niehues | Sacked | May 25 | 17th | Leandro Niehues (caretaker) | May 25 |
| Internacional | Jorge Fossati | Sacked | May 28 | 18th | Enderson Moreira (caretaker) | May 29 |
| Atlético Paranaense | Leandro Niehues (caretaker) | Replaced | May 31 | 19th | Paulo César Carpegiani | May 31 |