2010–11 TFF First League Managerial changes After the start of the season

| Team | Outgoing_manager | Manner_of_departure | Date_of_vacancy | Replaced_by | Date_of_appointment |
|---|---|---|---|---|---|
| Adanaspor | Cemal Gürsel Menteşe | Resignation | 26 Oct 2010 | Osman Özdemir | 09 Nov 2010 |
| Kartalspor | Ergün Penbe | Resignation | 09 Dec 2010 | Engin Korukır | 29.12.2010 |
| Karşıyaka | Kemal Kılıç | Mutual consent | 23 Dec 2010 | Turgut Uçar | 28 Dec 2010 |
| Diyarbakırspor | Engin Korukır | Mutual consent | 29 Dec 2010 | Ercan Albay | 02 Jan 2011 |
| Diyarbakırspor | Ercan Albay | resigned | 16 Jan 2011 | Nevzat Türker | 21 Jan 2011 |
| Denizlispor | Hamza Hamzaoğlu | resigned | 29 Jan 2011 | Kenan Atik | 17 Feb 2011 |
| Karşıyaka | Turgut Uçar | resigned | 21 Feb 2011 | Reha Kapsal | 22 Feb 2011 |
| Akhisar B.G.S. | Atilla Özcan | resigned | 27 Feb 2011 | Hamza Hamzaoğlu | 28 Feb 2011 |
| Adanaspor | Osman Özdemir | resigned | 27 Feb 2011 | Eyüp Arın | 28 Feb 2011 |