John Isner Singles: 16 (7 titles, 9 runners-up) Singles: 16 (7 titles, 9 runners-up)

| Outcome | Date_ | Surface | Opponent | Score |
|---|---|---|---|---|
| Runner-up | March 18, 2012 | Hard | Roger Federer | 6–7 (7–9) , 3–6 |
| Runner-up | April 15, 2012 | Clay | Juan Mónaco | 2–6, 6–3, 3–6 |
| Winner | July 15, 2012 | Grass | Lleyton Hewitt | 7–6 (7–1) , 6–4 |
| Winner | August 25, 2012 | Hard | Tomáš Berdych | 3–6, 6–4, 7–6 (11–9) |
| Winner | April 14, 2013 | Clay | Nicolás Almagro | 6–3, 7–5 |
| Winner | July 28, 2013 | Hard | Kevin Anderson | 6–7 (3–7) , 7–6 (7–2) , 7–6 (7–2) |
| Runner-up | August 4, 2013 | Hard | Juan Martín del Potro | 6–3, 1–6, 2–6 |
| Runner-up | August 18, 2013 | Hard | Rafael Nadal | 6–7 (8–10) , 6–7 (3–7) |