1980 New England Patriots season Schedule Schedule

| Week | Opponent | Result_ | Stadium | Record | Attendance |
|---|---|---|---|---|---|
| 1 | Cleveland Browns | W 34–17 | Schaefer Stadium | 1–0 | 49222 |
| 2 | Atlanta Falcons | L 21–37 | Schaefer Stadium | 1–1 | 48321 |
| 3 | at Seattle Seahawks | W 37–31 | Kingdome | 2–1 | 61035 |
| 4 | Denver Broncos | W 23–14 | Schaefer Stadium | 3–1 | 59602 |
| 5 | at New York Jets | W 21–11 | Shea Stadium | 4–1 | 53603 |
| 6 | Miami Dolphins | W 34–0 | Schaefer Stadium | 5–1 | 60377 |
| 7 | at Baltimore Colts | W 37–21 | Memorial Stadium | 6–1 | 53924 |
| 8 | at Buffalo Bills | L 13–31 | Rich Stadium | 6–2 | 75092 |
| 9 | New York Jets | W 34–21 | Schaefer Stadium | 7–2 | 60834 |
| 10 | at Houston Oilers | L 34–38 | Astrodome | 7–3 | 51524 |