1980 Buffalo Bills season NFL Draft NFL Draft

| Round | Pick_ | Player | Position_ | College |
|---|---|---|---|---|
| 1 | 16 | Jim Ritcher | Guard | North Carolina State |
| 2 | 29 | Joe Cribbs | Running back | Auburn |
| 2 | 37 | Gene Bradley | Quarterback | Arkansas State |
| 3 | 67 | Mark Brammer | Tight end | Michigan State |
| 3 | 71 | John Schmeding | Guard | Boston College |
| 4 | 93 | Ervin Parker | Linebacker | South Carolina St. |
| 5 | 119 | Jeff Pyburn | Defensive back | Georgia |
| 5 | 129 | Keith Lee | Defensive back | Colorado St. |
| 8 | 202 | Todd Krueger | Quarterback | Northern Michigan |
| 9 | 231 | Kent Davis | Defensive back | Southeast Missouri St. |
| 10 | 259 | Greg Cater | Punter | Tennessee-Chattanooga |
| 11 | 286 | Joe Gordon | Defensive tackle | Grambling St. |
| 12 | 316 | Roger Lapham | Tight end | Maine |