1981 Toronto Blue Jays season Game log September

| Date_ | Opponent | Score | Loss | Record |
|---|---|---|---|---|
| September 14 | Twins | 6–3 | Clancy (5–10) | 31–59 |
| September 15 | Twins | 4–2 | Arroyo (6–8) | 32–59 |
| September 16 | Twins | 5–2 | Berenguer (2–10) | 32–60 |
| September 18 | Angels | 5–1 | Witt (5–9) | 33–60 |
| September 19 | Angels | 6–4 | Frost (1–7) | 34–60 |
| September 20 | Angels | 6–3 | Zahn (9–11) | 35–60 |
| September 21 | Athletics | Postponed (rain) Rescheduled for September 22 | Postponed (rain) Rescheduled for September 22 | Postponed (rain) Rescheduled for September 22 |
| September 22 | Athletics | 3–2 (13) | Leal (7–11) | 35–61 |
| September 22 | Athletics | 4–2 | Berenguer (2–11) | 35–62 |
| September 23 | Athletics | 6–0 | Clancy (6–11) | 35–63 |
| September 25 | @ Angels | 11–5 | Leal (7–12) | 35–64 |
| September 26 | @ Angels | 6–3 | Berenguer (2–12) | 35–65 |