Science (UIL test) Individual (Chemistry) Individual (Chemistry)

| School_Year | Class_A | Class_AA | Class_AAA | Class_AAAA |
|---|---|---|---|---|
| 1998-99 | San Antonio Lackland | Jourdanton | Alvarado | (tie) Gregory-Portland/Sulphur Springs |
| 1999-2000 | Water Valley | Stinnett West Texas | Orangefield | Gregory-Portland |
| 2000-01 | Hedley | Stinnett West Texas | Seminole | Kingsville |
| 2001-02 | (unavailable) | (unavailable) | (unavailable) | (unavailable) |
| 2002-03 | (unavailable) | (Comfort) | (unavailable) | (unavailable) |
| 2003-04 | Avery | Argyle | Wimberley | Friendswood |
| 2004-05 | Academy | Floydada | Wimberley | Friendswood |
| 2005-06 | Avery | Harmony Science Academy | Cuero | Friendswood |
| 2006-07 | Houston Harmony Science Academy | Floydada | Cuero | North Richland Hills Birdville |
| 2007-08 | Moulton | New Boston | Wimberley | North Richland Hills Birdville |
| 2008-09 | Lindsay | White Oak | Wimberley | Frindswood |
| 2009-10 | Canadian | Irving North Hills | New Boston | Dallas Highland Park |
| 2010-11 | Canadian | White Oak | La Feria | Pearland Dawson |