John Isner Singles: 16 (7 titles, 9 runners-up) Singles: 16 (7 titles, 9 runners-up)

| Outcome | Date_ | Surface | Opponent | Score |
|---|---|---|---|---|
| Runner-up | August 5, 2007 | Hard | Andy Roddick | 4–6, 6–7 (4–7) |
| Winner | January 16, 2010 | Hard | Arnaud Clément | 6–3, 5–7, 7–6 (7–2) |
| Runner-up | February 21, 2010 | Hard (i) | Sam Querrey | 7–6 (7–3) , 6–7 (5–7) , 3–6 |
| Runner-up | May 9, 2010 | Clay | Sam Querrey | 6–3, 6–7 (4–7) , 4–6 |
| Runner-up | July 25, 2010 | Hard | Mardy Fish | 6–4, 4–6, 6–7 (4–7) |
| Winner | July 10, 2011 | Grass | Olivier Rochus | 6–3, 7–6 (8–6) |
| Runner-up | July 24, 2011 | Hard | Mardy Fish | 6–3, 6–7 (6–8) , 2–6 |
| Winner | August 27, 2011 | Hard | Julien Benneteau | 4–6, 6–3, 6–4 |