2005 Chicago White Sox season Game log April

| Date_ | Opponent | Score | Loss | Time_ | Att_ | Record |
|---|---|---|---|---|---|---|
| April 15 | Mariners | 6–4 | Piñeiro (0–1) | 2:39 | 16749 | 7–3 |
| April 16 | Mariners | 2–1 | Franklin (1–1) | 1:39 | 25931 | 8–3 |
| April 17 | Mariners | 4–5 | García (1–1) | 2:52 | 23324 | 8–4 |
| April 18 | Twins | 5–4 | Lohse (1–2) | 2:47 | 27018 | 9–4 |
| April 19 | Twins | 3–1 | Radke (1–3) | 2:40 | 18310 | 10–4 |
| April 20 | @ Tigers | 9–1 | Ledezma (1–1) | 2:19 | 16887 | 11–4 |
| April 21 | @ Tigers | 4–3 | Bonderman (2–2) | 2:21 | 19334 | 12–4 |
| April 22 | @ Royals | 8–2 | Hernández (1–3) | 2:36 | 15832 | 13–4 |
| April 23 | @ Royals | 3 – 2 (10) | MacDougal (1–1) | 3:24 | 19641 | 14–4 |
| April 24 | @ Royals | 4–3 | Camp (0–2) | 2:57 | 15331 | 15–4 |
| April 25 | @ Athletics | 6–0 | Zito (0–4) | 2:20 | 10206 | 16–4 |