2005–06 Manchester United F.C. season FA Premier League FA Premier League

| Date_ | Opponents | H_A | Result_F_A | Attendance | League_position |
|---|---|---|---|---|---|
| 13 August 2005 | Everton | A | 2–0 | 38610 | 4th |
| 20 August 2005 | Aston Villa | H | 1–0 | 67934 | 4th |
| 28 August 2005 | Newcastle United | A | 2–0 | 52327 | 4th |
| 10 September 2005 | Manchester City | H | 1–1 | 67839 | 4th |
| 18 September 2005 | Liverpool | A | 0–0 | 44917 | 3rd |
| 24 September 2005 | Blackburn Rovers | H | 1–2 | 67765 | 6th |
| 1 October 2005 | Fulham | A | 3–2 | 21862 | 4th |
| 15 October 2005 | Sunderland | A | 3–1 | 39085 | 3rd |
| 22 October 2005 | Tottenham Hotspur | H | 1–1 | 67856 | 5th |
| 29 October 2005 | Middlesbrough | A | 1–4 | 30579 | 7th |
| 6 November 2005 | Chelsea | H | 1–0 | 67864 | 4th |