2010 Southeastern Conference football season Week One Week One

| Date_ | Time_ | Visiting_team | Home_team | Site | Broadcast | Result_ | Attendance |
|---|---|---|---|---|---|---|---|
| September 2 | 7:30pm | Southern Miss | South Carolina | Williams-Brice Stadium • Columbia, SC | ESPN | W 41–13 | 70438 |
| September 4 | 12:00pm | Miami (OH) | #4 Florida | Ben Hill Griffin Stadium • Gainesville, FL | ESPN | W 34–12 | 90178 |
| September 4 | 12:21pm | Louisiana-Lafayette | #23 Georgia | Sanford Stadium • Athens, GA | SEC Network | W 55–7 | 92746 |
| September 4 | 3:30pm | Kentucky | Louisville | Papa John`s Cardinal Stadium • Louisville, KY | ABC | W 23–16 | 55327 |
| September 4 | 3:30pm | Jacksonville State | Mississippi | Vaught-Hemingway Stadium • Oxford, MS | CSS | L 48–49 2OT | 55768 |
| September 4 | 6:00pm | Tennessee-Martin | Tennessee | Neyland Stadium • Knoxville, TN | PPV | W 50–0 | 99123 |