1980–81 Coupe de France Round of 16 Round of 16

| Team_1 | Score | Team_2 | _1st_round | _2nd_round |
|---|---|---|---|---|
| RC Strasbourg (D1) | 3 - 2 | AS Angoulême (D2) | 2 - 0 | 1 - 2 |
| Thionville FC (D2) | 2 - 5 | FC Martigues (D2) | 2 - 2 | 0 - 3 |