1978 Buffalo Bills season NFL Draft NFL Draft

| Round | Pick_ | Player | Position_ | College |
|---|---|---|---|---|
| 1 | 5 | Terry Miller | Running back | Oklahoma State |
| 2 | 33 | Dee Hardison | Defensive end | North Carolina |
| 2 | 38 | Scott Hutchinson | Defensive end | Florida |
| 3 | 59 | Dennis Johnson | Running back | Mississippi State |
| 3 | 65 | Danny Fulton | Wide receiver | Nebraska-Omaha |
| 4 | 89 | Lucius Sanford | Linebacker | Georgia Tech |
| 5 | 114 | Ken Spaeth | Tight end | Nebraska |
| 6 | 145 | Eric Smith | Tackle | Southern Mississippi |
| 7 | 171 | Mario Celotto | Linebacker | USC |
| 7 | 183 | Steve Powell | Running back | N.E. Missouri State |
| 10 | 255 | Will Grant | Center | Kentucky |
| 11 | 282 | Jerry Blanton | Linebacker | Kentucky |
| 12 | 309 | Richard Crump | Running back | N.E. Oklahoma A&M |