2000 Cleveland Indians season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 1 | Orioles | 5 - 2 | Ponson (7-10) | 42647 | 71-60 |
| September 2 | Orioles | 8 - 6 | Karsay (4-7) | 42736 | 71-61 |
| September 3 | Orioles | 12 - 11 (13) | Trombley (4-5) | 42630 | 72-61 |
| September 4 | Devil Rays | 5 - 1 | Lopez (11-10) | 42628 | 73-61 |
| September 5 | Devil Rays | 7 - 4 | Fiore (1-1) | 42660 | 74-61 |
| September 6 | Devil Rays | 6 - 2 | Harper (0-1) | 42742 | 75-61 |
| September 7 | Devil Rays | 4 - 3 | Karsay (4-8) | 42709 | 75-62 |
| September 8 | White Sox | 5 - 4 | Woodard (1-3) | 42526 | 75-63 |
| September 9 | White Sox | 9 - 3 | Garland (3-6) | 42561 | 76-63 |