1946 San Francisco 49ers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Score | Record |
|---|---|---|---|---|---|
| 1 | September 6, 1946 | New York Yankees | L | 21-7 | 0-1 |
| 2 | September 15, 1946 | Miami Seahawks | W | 21-14 | 1-1 |
| 3 | September 22, 1946 | Brooklyn Dodgers | W | 32-13 | 2-1 |
| 4 | September 29, 1946 | at Chicago Rockets | L | 24-7 | 2-2 |
| 5 | October 8, 1946 | at Miami Seahawks | W | 34-7 | 3-2 |
| 6 | October 12, 1946 | at Los Angeles Dons | W | 23-14 | 4-2 |
| 7 | October 19, 1946 | at Buffalo Bisons | L | 17-14 | 4-3 |
| 8 | October 27, 1946 | at Cleveland Browns | W | 34-20 | 5-3 |
| 9 | November 2, 1946 | Buffalo Bisons | W | 27-14 | 6-3 |
| 10 | November 10, 1946 | Cleveland Browns | L | 14-7 | 6-4 |