1991 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Game_Site | Final_Score | Record | TV_Time | Attendance |
|---|---|---|---|---|---|---|---|
| 1 | September 1, 1991 | Miami Dolphins | Rich Stadium | W 35–31 | 1–0 | NBC 4:15pm | 80252 |
| 2 | September 8, 1991 | Pittsburgh Steelers | Rich Stadium | W 52–34 | 2–0 | NBC 1:00pm | 79545 |
| 3 | September 15, 1991 | at New York Jets | The Meadowlands | W 23–20 | 3–0 | NBC 4:15pm | 65309 |
| 4 | September 22, 1991 | at Tampa Bay Buccaneers | Tampa Stadium | W 17–10 | 4–0 | NBC 4:15pm | 57323 |
| 5 | September 29, 1991 | Chicago Bears | Rich Stadium | W 35–20 | 5–0 | CBS 1:00pm | 80366 |
| 6 | October 7, 1991 | at Kansas City Chiefs | Arrowhead Stadium | L 6–33 | 5–1 | ABC 9:00pm | 76120 |