2008 San Francisco Giants season Game log May

| Date_ | Opponent | Score | Loss | Record |
|---|---|---|---|---|
| May 16 | White Sox | 2–0 | Sánchez (2–3) | 17–26 |
| May 17 | White Sox | 3–1 | Zito (0–8) | 17–27 |
| May 18 | White Sox | 13–8 | Walker (1–2) | 17–28 |
| May 19 | @ Rockies | 4–3 | Chulk (0–3) | 17–29 |
| May 20 | @ Rockies | 6–5 | Cook (6–3) | 18–29 |
| May 21 | @ Rockies | 3 – 2 (10) | Herges (2–1) | 19–29 |
| May 23 | @ Marlins | 8–2 | Olsen (4–2) | 20–29 |
| May 24 | @ Marlins | Postponed (rain) Rescheduled for May 25 | Postponed (rain) Rescheduled for May 25 | Postponed (rain) Rescheduled for May 25 |
| May 25 | @ Marlins | 8–6 | Misch (0–1) | 20–30 |
| May 25 | @ Marlins | 5–4 | Walker (2–3) | 20–31 |
| May 27 | @ D-backs | 6–3 | Haren (5–4) | 21–31 |