2010 Southeastern Conference football season Week Two Week Two

| Date_ | Time_ | Visiting_team | Home_team | Site | Broadcast | Result_ | Attendance |
|---|---|---|---|---|---|---|---|
| September 9 | 7:30pm | #21 Auburn | Mississippi State | Davis Wade Stadium • Starkville, MS | ESPN | AUB 17–14 | 54806 |
| September 11 | 12:00pm | #22 Georgia | #24 South Carolina | Williams-Brice Stadium • Columbia, SC | ESPN | USC 17–6 | 80974 |
| September 11 | 12:21pm | South Florida | #8 Florida | Ben Hill Griffin Stadium • Gainesville, FL | SEC Network | W 38–14 | 90612 |
| September 11 | 7:00pm | #19 LSU | Vanderbilt | Vanderbilt Stadium • Nashville, TN | ESPNU | LSU 27–3 | 36940 |
| September 11 | 7:00pm | #19 Penn State | #1 Alabama | Bryant–Denny Stadium • Tuscaloosa, AL | ESPN | W 24–3 | 101821 |