2005–06 U.S. Città di Palermo season Serie A Serie A

| Date_and_time | Opponent | Venue | Result_ | Attendance |
|---|---|---|---|---|
| March 19, 2006 – 15.00 | Sampdoria | Away | Won 2-0 | 21073 |
| March 26, 2006 – 15.00 | Treviso | Home | Won 1-0 | 26025 |
| April 2, 2006 – 15.00 | Ascoli | Home | Drew 1-1 | 26440 |
| April 9, 2006 – 15.00 | Cagliari | Away | Drew 1-1 | 10000 |
| April 15, 2006 – 15.00 | AS Roma | Home | Drew 3-3 | 27855 |
| April 22, 2006 – 15.00 | Livorno | Away | Lost 1-3 | 10635 |
| April 30, 2006 – 15.00 | Fiorentina | Home | Won 1-0 | 30056 |
| May 7, 2006 – 15.00 | Juventus | Away | Lost 1-2 | 56488 |
| May 14, 2006 – 15.00 | Messina | Home | Won 1-0 | 26558 |