1965 Boston Patriots season Game-by-game results Game-by-game results

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 11, 1965 | at Buffalo Bills | L 24-7 | 45502 |
| 2 | September 19, 1965 | at Houston Oilers | L 31-10 | 32445 |
| 3 | September 24, 1965 | Denver Broncos | L 27-10 | 26782 |
| 4 | October 3, 1965 | at Kansas City Chiefs | L 27-17 | 26773 |
| 5 | October 8, 1965 | Oakland Raiders | L 24-10 | 24824 |
| 6 | October 17, 1965 | San Diego Chargers | T 13-13 | 20924 |
| 7 | October 24, 1965 | at Oakland Raiders | L 30-21 | 20858 |
| 8 | October 31, 1965 | at San Diego Chargers | W 22–6 | 33366 |
| 9 | November 7, 1965 | Buffalo Bills | L 23-7 | 24415 |
| 10 | November 14, 1965 | New York Jets | L 30-20 | 18589 |