1980–81 FA Cup Fourth Round Proper Fourth Round Proper

| Tie_no | Home_team | Score | Away_team | Date_ |
|---|---|---|---|---|
| 9 | Wrexham | 2–1 | Wimbledon | 24 January 1981 |
| 10 | Newcastle United | 2–1 | Luton Town | 24 January 1981 |
| 11 | Tottenham Hotspur | 2–0 | Hull City | 24 January 1981 |
| 12 | Manchester City | 6–0 | Norwich City | 24 January 1981 |
| 13 | Fulham | 1–2 | Charlton Athletic | 24 January 1981 |
| 14 | Barnsley | 1–1 | Enfield | 24 January 1981 |
| Replay | Enfield | 0–3 | Barnsley | 28 January 1981 |
| 15 | Coventry City | 3–2 | Birmingham City | 24 January 1981 |
| 16 | Carlisle United | 1–1 | Bristol City | 24 January 1981 |
| Replay | Bristol City | 5–0 | Carlisle United | 28 January 1981 |