John Isner Wins over top-10 players per season Wins over top-10 players per season

| Player | Rank_ | Event | Surface | Score |
|---|---|---|---|---|
| Roger Federer | 3 | Davis Cup , Fribourg, Switzerland | Clay (i) | 4–6, 6–3, 7–6 (7–4) , 6–2 |
| Novak Djokovic | 1 | Indian Wells , United States | Hard | 7–6 (9–7) , 3–6, 7–6 (7–5) |
| Jo-Wilfried Tsonga | 6 | Davis Cup , Roquebrune-Cap-Martin, France | Clay | 6–3, 7–6 (7–4) , 5–7, 6–3 |
| Janko Tipsarević | 8 | Olympics , London, England | Grass | 7–5, 7–6 (16–14) |
| Jo-Wilfried Tsonga | 6 | Winston-Salem , United States | Hard | 6–4, 3–6, 7–6 (7–3) |
| Tomáš Berdych | 7 | Winston-Salem, United States | Hard | 3–6, 6–4, 7–6 (11–9) |
| 2013 | 2013 | 2013 | 2013 | 2013 |
| Milos Raonic | 10 | Cincinnati , United States | Hard | 7–6 (7–5) , 6–4 |
| Novak Djokovic | 1 | Cincinnati, United States | Hard | 7–6 (7–5) , 3–6, 7–5 |
| Juan Martín del Potro | 7 | Cincinnati, United States | Hard | 6–7 (5–7) , 7–6 (11–9) , 6–3 |