2008 Cleveland Indians season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 13 | Athletics | 7–1 | Gaudin (0–1) | 17228 | 5–7 |
| April 14 | Red Sox | 6–4 | Borowski (0–2) | 21802 | 5–8 |
| April 15 | Red Sox | 5–3 | Lewis (0–1) | 25135 | 5–9 |
| April 16 | Tigers | 13–2 | Sabathia (0–3) | 17644 | 5–10 |
| April 17 | Tigers | 11–1 | Verlander (0–3) | 21547 | 6–10 |
| April 18 | @ Twins | 4–0 | Liriano (0–2) | 22366 | 7–10 |
| April 19 | @ Twins | 3–0 | Westbrook (1–2) | 34210 | 7–11 |
| April 20 | @ Twins | 2 – 1 (10) | Pérez (0–1) | 27703 | 7–12 |
| April 22 | @ Royals | 15–1 | Meche (1–3) | 16165 | 8–12 |