1921–22 Manchester United F.C. season First Division First Division

| Date_ | Opponents | H_A | Result_F_A | Scorers | Attendance_ |
|---|---|---|---|---|---|
| 14 January 1922 | Newcastle United | H | 0–1 |  | 20000 |
| 21 January 1922 | Sunderland | A | 1–2 | Sapsford | 10000 |
| 28 January 1922 | Sunderland | H | 3–1 | Lochhead, Sapsford, Spence | 18000 |
| 11 February 1922 | Huddersfield Town | H | 1–1 | Spence | 30000 |
| 18 February 1922 | Birmingham | A | 1–0 | Spence | 20000 |
| 25 February 1922 | Birmingham | H | 1–1 | Sapsford | 35000 |
| 27 February 1922 | Huddersfield Town | A | 1–1 | Sapsford | 30000 |
| 11 March 1922 | Arsenal | H | 1–0 | Spence | 30000 |
| 18 March 1922 | Blackburn Rovers | H | 0–1 |  | 30000 |
| 25 March 1922 | Blackburn Rovers | A | 0–3 |  | 15000 |
| 1 April 1922 | Bolton Wanderers | H | 0–1 |  | 28000 |
| 5 April 1922 | Arsenal | A | 1–3 | Lochhead | 25000 |
| 8 April 1922 | Bolton Wanderers | A | 0–1 |  | 28000 |