House of Medici List of heads of the Medici Signore in the Republic of Florence

| Name_ | From_ | Until_ | Relationship_with_predecessor_ |
|---|---|---|---|
| Piero II de` Medici , (Piero the Unfortunate) | 9 April 1492 | 8 November 1494 | Eldest son of Lorenzo the Magnificent. Overthrown when Charles VIII of France invaded as a full republic was restored, first under the theocracy of Girolamo Savonarola and then statesman Piero Soderini. |
| Cardinal Giovanni de` Medici | 31 August 1512 | 9 March 1513 | Brother of Piero the Unfortunate, second son of Lorenzo the Magnificent. Elected to the Papacy, becoming Pope Leo X. |
| Giuliano de` Medici, Duke of Nemours | 9 March 1513 | 17 March 1516 | Brother of Cardinal Giovanni de` Medici, third son of Lorenzo the Magnificent. |
| Lorenzo II de` Medici, Duke of Urbino | 17 March 1516 | 4 May 1519 | Nephew of Giuliano de` Medici, Duke of Nemours, son of Piero the Unfortunate. |