2006 Chicago Cubs season Game log June

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| June 14 | Astros | 5–4 | Maddux (7–6) | 39946 | 26–38 |
| June 15 | Astros | 3–2 | Howry (2–2) | 40236 | 26–39 |
| June 16 | Tigers | 5–3 | Rusch (2–7) | 40683 | 26–40 |
| June 17 | Tigers | 9–3 | Mármol (1–1) | 41459 | 26–41 |
| June 18 | Tigers | 12–3 | Prior (0–1) | 39938 | 26–42 |
| June 19 | @ Indians | 12–8 | Johnson (3–8) | 26769 | 27–42 |
| June 20 | @ Indians | 4–2 | Maddux (7–7) | 25049 | 27–43 |
| June 21 | @ Indians | 9–2 | Sabathia (5–4) | 27182 | 28–43 |
| June 23 | @ Twins | 7–2 | Mármol (1–2) | 34361 | 28–44 |
| June 24 | @ Twins | 3–0 | Prior (0–2) | 42304 | 28–45 |
| June 25 | @ Twins | 8–1 | Marshall (4–6) | 35128 | 28–46 |
| June 26 | Brewers | 6–0 | Maddux (7–8) | 39698 | 28–47 |