House of Medici List of heads of the Medici Signore in the Republic of Florence

| Name_ | From_ | Until_ | Relationship_with_predecessor_ |
|---|---|---|---|
| Cardinal Giulio de` Medici | 4 May 1519 | 19 November 1523 | Cousin of Lorenzo II de` Medici, Duke of Urbino, son of Giuliano de` Medici who was the brother of Lorenzo the Magnificent. Elected to the Papacy, becoming Pope Clement VII. |
| Cardinal Ippolito de` Medici | 19 November 1523 | 24 October 1529 | Cousin of Cardinal Giulio de` Medici, illegitimate son of Giuliano de` Medici, Duke of Nemours. |