2010–11 Buffalo Sabres season Game log October

| Game | October | Opponent | Score | Decision | Location_Attendance | Record |
|---|---|---|---|---|---|---|
| 1 | 8 | @ Ottawa Senators | 2-1 | Miller | Scotiabank Place/19,350 | 1-0-0 |
| 2 | 9 | New York Rangers | 3-6 | Miller | HSBC Arena/18,690 | 1-1-0 |
| 3 | 11 | Chicago Blackhawks | 3-4 | Miller | HSBC Arena/17,896 | 1-2-0 |
| 4 | 13 | New Jersey Devils | 0-1 (OT) | Miller | HSBC Arena/18,690 | 1-2-1 |
| 5 | 15 | Montreal Canadiens | 1-2 | Miller | HSBC Arena/17,264 | 1-3-1 |
| 6 | 16 | @ Chicago Blackhawks | 3-4 | Lalime | United Center/21,293 | 1-4-1 |
| 7 | 20 | @ Atlanta Thrashers | 4-1 | Miller | Philips Arena/8,820 | 2-4-1 |
| 8 | 22 | Ottawa Senators | 2-4 | Miller | HSBC Arena/18,009 | 2-5-1 |
| 9 | 23 | @ New Jersey Devils | 6-1 | Miller | Prudential Center/14,228 | 3-5-1 |
| 10 | 26 | @ Philadelphia Flyers | 3-6 | Miller | Wells Fargo Center/19,361 | 3-6-1 |
| 11 | 29 | @ Atlanta Thrashers | 3-4 (OT) | Miller | Philips Arena/10,172 | 3-6-2 |