1990 Buffalo Bills season NFL Draft NFL Draft

| Round | Pick_ | Player | Position_ | College |
|---|---|---|---|---|
| 1 | 16 | James Williams | Defensive back | Fresno State |
| 2 | 43 | Carwell Gardner | Running back | Louisville |
| 3 | 70 | Glenn Parker | Guard | Arizona |
| 4 | 101 | Eddie Fuller | Running back | LSU |
| 6 | 155 | John Nies | Punter | Arizona |
| 7 | 167 | Brent Griffith | Guard | Minnesota-Duluth |
| 7 | 171 | Brent Collins | Linebacker | Carson-Newman |
| 7 | 182 | Fred DeRiggi | Nose tackle | Syracuse |
| 8 | 209 | Marvcus Patton | Middle Linebacker | UCLA |
| 9 | 239 | Clarkston Hines | Wide receiver | Duke |
| 10 | 266 | Mike Lodish | Defensive tackle | UCLA |
| 11 | 293 | Al Edwards | Wide receiver | Northwestern State, La. |