2008 Houston Texans season Regular season Regular season

| Week | Date_ | Opponent | Result_ | Game_site | Record | Match_Report |
|---|---|---|---|---|---|---|
| 1 | September 7, 2008 | at Pittsburgh Steelers | L 38–17 | Heinz Field | 0–1 | Recap |
| 2 | Bye due to Hurricane Ike | Bye due to Hurricane Ike | Bye due to Hurricane Ike | Bye due to Hurricane Ike | Bye due to Hurricane Ike | Bye due to Hurricane Ike |
| 3 | September 21, 2008 | at Tennessee Titans | L 31–12 | LP Field | 0–2 | Recap |
| 4 | September 28, 2008 | at Jacksonville Jaguars | L 30–27 OT | Jacksonville Municipal Stadium | 0–3 | Recap |
| 5 | October 5, 2008 | Indianapolis Colts | L 31–27 | Reliant Stadium | 0–4 | Recap |
| 6 | October 12, 2008 | Miami Dolphins | W 29–28 | Reliant Stadium | 1–4 | Recap |