2010 US Open (tennis) Single seeds Women's singles

| Seed | Rank_ | Player | Points | Points_defending | Points_won | New_points | Status_ |
|---|---|---|---|---|---|---|---|
| 17 | 19 | Nadia Petrova | 3345 | 280 | 5 | 3070 | 1st round lost to Andrea Petkovic |
| 18 | 20 | Aravane Rezaï | 3005 | 5 | 100 | 3100 | 2nd round lost to Beatrice Capra [WC] |
| 19 | 21 | Flavia Pennetta | 2905 | 500 | 160 | 2565 | 3rd round lost to Shahar Pe`er [16] |
| 20 | 22 | Anastasia Pavlyuchenkova | 2505 | 5 | 280 | 2780 | 4th round lost to Francesca Schiavone [6] |
| 21 | 23 | Zheng Jie | 2351 | 160 | 100 | 2291 | 2nd round lost to Ana Ivanovic |
| 22 | 24 | María José Martínez Sánchez | 2285 | 160 | 100 | 2225 | 2nd round lost to Patty Schnyder |
| 23 | 25 | Maria Kirilenko | 2275 | 160 | 160 | 2275 | 3rd round lost to Svetlana Kuznetsova [11] |