1980 Buffalo Bills season Schedule Schedule

| Game | Date_ | Opponent | Result_ | Bills_points | Opponents | Bills_first_downs | Record | Attendance |
|---|---|---|---|---|---|---|---|---|
| 9 | Nov. 2 | Atlanta Falcons | Loss | 14 | 30 | 20 | 6–3 | 57959 |
| 10 | Nov. 9 | at New York Jets | Win | 31 | 24 | 17 | 7–3 | 45677 |
| 11 | Nov. 16 | at Cincinnati Bengals | Win | 14 | 0 | 22 | 8–3 | 40836 |
| 12 | Nov. 23 | Pittsburgh Steelers | Win | 28 | 13 | 23 | 9–3 | 79659 |
| 13 | Nov. 30 | at Baltimore Colts | Loss | 24 | 28 | 24 | 9–4 | 36184 |
| 14 | Dec. 7 | Los Angeles Rams | Win | 10 | 7 | 15 | 10–4 | 77133 |
| 15 | Dec. 14 | at New England Patriots | Loss | 2 | 24 | 28 | 10–5 | 58324 |