2008 Arizona Cardinals season Regular season Regular season

| Week | Date_ | Time_ | Opponent | Result_ | Game_site | NFL_Recap | Record |
|---|---|---|---|---|---|---|---|
| 1 | September 7, 2008 | 1:15 p.m. | at San Francisco 49ers | W 23–13 | Candlestick Park | Recap | 1–0 |
| 2 | September 14, 2008 | 1:15 p.m. | Miami Dolphins | W 31–10 | University of Phoenix Stadium | Recap | 2–0 |
| 3 | September 21, 2008 | 10:00 a.m. | at Washington Redskins | L 24–17 | FedEx Field | Recap | 2–1 |
| 4 | September 28, 2008 | 10:00 a.m. | at New York Jets | L 56–35 | Giants Stadium | Recap | 2–2 |
| 5 | October 5, 2008 | 1:15 p.m. | Buffalo Bills | W 41–17 | University of Phoenix Stadium | Recap | 3–2 |
| 6 | October 12, 2008 | 1:15 p.m. | Dallas Cowboys | W 30–24 OT | University of Phoenix Stadium | Recap | 4–2 |