List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation

| Year_ | City | State_province_dept_etc_ | Country | Notes_ |
|---|---|---|---|---|
| 1749 | Alexandria | Virginia | United States |  |
| 1749 | San Ignacio de Velasco | Santa Cruz Department | Bolivia |  |
| 1749 | Port-au-Prince | Ouest Department | Haiti |  |
| 1749 | Halifax | Nova Scotia | Canada |  |
| 1749 | Windsor | Ontario | Canada | Oldest continually-inhabited settlement in Canada west of Montreal |
| 1752 | Buíque | Pernambuco | Brazil |  |
| 1752 | Patos | Paraíba | Brazil | Declared vila in 1832; cidade in 1903. |
| 1752 | Tubac | Arizona | United States |  |
| 1754 | Augusta | Maine | United States |  |
| 1755 | Charlotte | North Carolina | United States |  |
| 1756 | Salto | Salto | Uruguay |  |
| 1756 | Santa Bárbara de Samaná | Samaná | Dominican Republic |  |
| 1756 | Yauco | Puerto Rico | United States |  |
| 1757 | Estância | Sergipe | Brazil |  |
| 1758 | Pittsburgh | Pennsylvania | United States |  |
| 1758 | Macapá | Amapá | Brazil |  |
| 1760 | Arês | Rio Grande do Norte | Brazil |  |