2006 Toronto Blue Jays season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 15 | @ White Sox | 4–2 | Burnett (0–1) | 33247 | 6–5 |
| April 16 | @ White Sox | 6–4 (5) | Towers (0–3) | 27137 | 6–6 |
| April 18 | Yankees | 10–5 | Johnson (2–2) | 48776 | 7–6 |
| April 19 | Yankees | 3–1 | Lilly (1–1) | 32886 | 7–7 |
| April 21 | Red Sox | 7–6 (12) | Foulke (0–1) | 28333 | 8–7 |
| April 22 | Red Sox | 8–1 | DiNardo (0–1) | 34387 | 9–7 |
| April 23 | Red Sox | 6–3 | Towers (0–4) | 28737 | 9–8 |
| April 25 | Orioles | 7–3 | López (1–2) | 32257 | 10–8 |
| April 26 | Orioles | 8–2 | Bédard (4–1) | 19336 | 11–8 |
| April 27 | Orioles | 7–5 | Janssen (0–1) | 18756 | 11–9 |
| April 28 | @ Yankees | 7–2 | Wright (0–2) | 47204 | 12–9 |
| April 29 | @ Yankees | 17–6 | Towers (0–5) | 50119 | 12–10 |
| April 30 | @ Yankees | 4–1 | Chacín (4–1) | 52954 | 12–11 |