2008 New York Yankees season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 12 | @ Red Sox | 4–3 | Mussina (1–2) | 37461 | 6–6 |
| April 13 | @ Red Sox | 8–5 | Hughes (0–2) | 37876 | 6–7 |
| April 14 | @ Rays | 8–7 | Reyes (1–2) | 18872 | 7–7 |
| April 15 | @ Rays | 5–3 | Jackson (2–1) | 20923 | 8–7 |
| April 16 | Red Sox | 15–9 | Tavárez (0–1) | 54667 | 9–7 |
| April 17 | Red Sox | 7–5 | Mussina (1–3) | 55088 | 9–8 |
| April 18 | @ Orioles | 8–2 | Hughes (0–3) | 40653 | 9–9 |
| April 19 | @ Orioles | 6–0 | Kennedy (0–2) | 41776 | 9–10 |
| April 20 | @ Orioles | 7–1 | Trachsel (1–3) | 37501 | 10–10 |
| April 22 | @ White Sox | 9–5 | Contreras (1–2) | 25012 | 11–10 |
| April 23 | @ White Sox | 6–4 | Vázquez (3–2) | 27751 | 12–10 |