List of North Queensland Cowboys records Biggest Wins Biggest Wins

| Margin | Opponent | Score | Venue | Date_ |
|---|---|---|---|---|
| 52 | South Sydney Rabbitohs | 60-8 | Dairy Farmers Stadium | Rd 24 - 23 August 2003 |
| 46 | St. George Illawarra Dragons | 50-4 | Dairy Farmers Stadium | Rd 13 - 29 April 2000 |
| 42 | Cronulla Sharks | 56-14 | Dairy Farmers Stadium | Rd 13 - 4 June 2005 |
| 40 | Northern Eagles | 50-10 | Dairy Farmers Stadium | Rd 23 - 25 March 2000 |
| 40 | New Zealand Warriors | 52-12 | Dairy Farmers Stadium | Rd 8 - 11 August 2012 |