Most lethal American battles Battles Battles

| Battle_Siege_or_Offensive | Conflict | Dates | Estimated_number_of_Americans_killed_ |
|---|---|---|---|
| Battle of Antietam | American Civil War | September 17, 1862 | 3,654 killed (2,108 Union and 1,546 Confederacy) |
| Battle of Shiloh | American Civil War | April 6 to April 7, 1862 | 3,482 killed (1,754 Union and 1,728 Confederacy) |
| Battle of Chancellorsville | American Civil War | April 30 to May 6, 1863 | 3,271 killed (1,606 Union and 1,665 Confederacy) |
| Battle of Saipan | World War II | June 15 to July 9 1944 | 2,949 killed |
| Battle of Sicily | World War II | July 9 to August 17, 1943 | 2,572 killed |
| Pearl Harbor Attack | World War II | December 7, 1941 | 2,500 killed |
| Battle of Salerno | World War II | September 3 – September 16, 1943 | 2,000 killed |