1980 Buffalo Bills season Schedule Schedule

| Game | Date_ | Opponent | Result_ | Bills_points | Opponents | Bills_first_downs | Record | Attendance |
|---|---|---|---|---|---|---|---|---|
| 1 | Sept. 7 | Miami Dolphins | Win | 17 | 7 | 22 | 1–0 | 79598 |
| 2 | Sept. 14 | New York Jets | Win | 20 | 10 | 22 | 2–0 | 65315 |
| 3 | Sept. 21 | at New Orleans Saints | Win | 35 | 26 | 26 | 3–0 | 51154 |
| 4 | Sept. 28 | Oakland Raiders | Win | 24 | 7 | 25 | 4–0 | 77259 |
| 5 | Oct. 5 | at San Diego Chargers | Win | 26 | 24 | 14 | 5–0 | 51982 |
| 6 | Oct. 12 | Baltimore Colts | Loss | 12 | 17 | 24 | 5–1 | 73634 |
| 7 | Oct. 19 | at Miami Dolphins | Loss | 14 | 17 | 18 | 5–2 | 41636 |
| 8 | Oct. 26 | New England Patriots | Win | 31 | 13 | 21 | 6–2 | 75092 |