2008 Houston Astros season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 1 | @ Padres | 1–2 | Backe (0–1) | 20825 | 0–2 |
| April 2 | @ Padres | 9–6 | Hoffman (0–1) | 18714 | 1–2 |
| April 3 | @ Padres | 2–3 | Villareal (0–1) | 24432 | 1–3 |
| April 4 | @ Cubs | 4–3 | Lieber (0–1) | 37812 | 2–3 |
| April 5 | @ Cubs | 7–9 | Oswalt (0–2) | 40707 | 2–4 |
| April 6 | @ Cubs | 2–3 | Villarreal (0–2) | 40929 | 2–5 |
| April 7 | Cardinals | 5–3 | McClellan (0–1) | 43483 | 3–5 |
| April 8 | Cardinals | 3–5 | Geary (0–1) | 30184 | 3–6 |
| April 9 | Cardinals | 4–6 | Sampson (0–1) | 29187 | 3–7 |
| April 11 | Marlins | 6–10 | Oswalt (0–3) | 34191 | 3–8 |
| April 12 | Marlins | 5–0 | Miller (0–2) | 34336 | 4–8 |