1981 Toronto Blue Jays season Game log September

| Date_ | Opponent | Score | Loss | Record |
|---|---|---|---|---|
| September 1 | @ Rangers | 9–3 | Darwin (8–7) | 26–52 |
| September 2 | @ Rangers | 4–1 | Leal (4–10) | 26–53 |
| September 3 | @ White Sox | 4–3 | Berenguer (2–7) | 26–54 |
| September 4 | @ White Sox | 6–2 | Lamp (5–3) | 27–54 |
| September 5 | @ White Sox | 3–1 | Baumgarten (5–8) | 28–54 |
| September 6 | @ White Sox | 3–2 | Burns (8–3) | 29–54 |
| September 7 | @ Twins | 4–0 | Berenguer (2–8) | 29–55 |
| September 8 | @ Twins | 1–0 | Stieb (8–10) | 29–56 |
| September 9 | @ Twins | 3–1 | Clancy (5–9) | 29–57 |
| September 10 | Mariners | 2–0 | Clay (0–6) | 30–57 |
| September 11 | Mariners | 8–1 | Berenguer (2–9) | 30–58 |
| September 12 | Mariners | 3–0 | Beattie (2–2) | 31–58 |