1961 Buffalo Bills season Regular season Regular season

| Week | Date_ | Opponent | Result_ | Stadium | Record | Attendance |
|---|---|---|---|---|---|---|
| 1 | September 10, 1961 | Denver Broncos | L 22–10 | War Memorial Stadium | 0–1 | 16636 |
| 2 | September 17, 1961 | New York Titans | W 41–31 | War Memorial Stadium | 1–1 | 15584 |
| 3 | September 23, 1961 | Boston Patriots | L 23–21 | War Memorial Stadium | 1–2 | 21504 |
| 4 | September 30, 1961 | San Diego Chargers | L 19–11 | War Memorial Stadium | 1–3 | 20742 |
| 5 | October 8, 1961 | at Houston Oilers | W 22–12 | Jeppesen Stadium | 2–3 | 22761 |
| 6 | October 15, 1961 | Dallas Texans | W 27–24 | War Memorial Stadium | 3–3 | 20678 |
| 7 | October 22, 1961 | at Boston Patriots | L 52–21 | Boston University Field | 3–4 | 9398 |