2008 CAF Confederation Cup First Round of 16 First Round of 16

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| US Masséda | 2–6 | Espérance | 1–0 | 1–6 |
| Djoliba | 5–2 | AS Mangasport | 3–1 | 2–1 |
| ASC Linguère | 4–4( a ) | CS Sfaxien | 3–2 | 1–2 |
| Les Astres FC | ( a )1–1 | AS Vita Club | 0–0 | 1–1 |
| Al Akhdar | 1–2 | Haras El Hodood | 1–1 | 0–1 |
| Highlanders FC | 1–5 | Al-Merrikh | 0–2 | 1–3 |
| Ajax Cape Town | 5–6 | Mount Cameroon FC | 5–1 | 0–5 |
| Dolphins | 3–4 | Asante Kotoko | 2–0 | 1–4 1 |