1985 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 8, 1985 | San Diego Chargers | L 14–9 | 67597 |
| 2 | September 15, 1985 | at New York Jets | L 42–3 | 63449 |
| 3 | September 22, 1985 | New England Patriots | L 17–14 | 40334 |
| 4 | September 29, 1985 | Minnesota Vikings | L 27–20 | 45667 |
| 5 | October 6, 1985 | at Indianapolis Colts | L 49–17 | 60003 |
| 6 | October 13, 1985 | at New England Patriots | L 14–3 | 40462 |
| 7 | October 20, 1985 | Indianapolis Colts | W 21–9 | 28430 |
| 8 | October 27, 1985 | at Philadelphia Eagles | L 21–17 | 60987 |
| 9 | November 3, 1985 | Cincinnati Bengals | L 23–17 | 25640 |
| 10 | November 10, 1985 | Houston Oilers | W 20–0 | 21881 |