1980–81 FA Cup First round proper First round proper

| Tie_no | Home_team | Score | Away_team | Date_ |
|---|---|---|---|---|
| 12 | Lincoln City | 1–0 | Gateshead | 22 November 1980 |
| 13 | Swindon Town | 3–2 | Weymouth | 22 November 1980 |
| 14 | Tranmere Rovers | 0–0 | York City | 22 November 1980 |
| Replay | York City | 1–2 | Tranmere Rovers | 25 November 1980 |
| 15 | Stockport County | 0–0 | Sheffield United | 22 November 1980 |
| Replay | Sheffield United | 3–2 | Stockport County | 25 November 1980 |
| 16 | Wycombe Wanderers | 0–3 | Bournemouth | 22 November 1980 |
| 17 | Kidderminster Harriers | 1–1 | Millwall | 22 November 1980 |
| Replay | Millwall | 1–0 | Kidderminster Harriers | 25 November 1980 |
| 18 | Brentford | 2–2 | Addlestone & Weybridge Town | 22 November 1980 |
| Replay | Brentford | 2–0 | Addlestone & Weybridge Town | 25 November 1980 |
| 19 | Northampton Town | 1–4 | Peterborough United | 22 November 1980 |