Bob Bryan career statistics Mixed doubles: 9 (7–2) Mixed doubles: 9 (7–2)

| Outcome | Year_ | Championship | Surface | Partner | Opponents | Score |
|---|---|---|---|---|---|---|
| Runner-up | 2002 | US Open | Hard | Katarina Srebotnik | Lisa Raymond Mike Bryan | 7–6 (11–9) , 7–6 (7–1) |
| Winner | 2003 | US Open | Hard | Katarina Srebotnik | Lina Krasnoroutskaya Daniel Nestor | 5–7, 7–5, [10–5] |
| Winner | 2004 | US Open (2) | Hard | Vera Zvonareva | Alicia Molik Todd Woodbridge | 6–3, 6–4 |
| Runner-up | 2006 | Wimbledon | Grass | Venus Williams | Vera Zvonareva Andy Ram | 6–3, 6–2 |
| Winner | 2006 | US Open (3) | Hard | Martina Navratilova | Květa Peschke Martin Damm | 6–2, 6–3 |
| Winner | 2008 | French Open | Clay | Victoria Azarenka | Katarina Srebotnik Nenad Zimonjić | 6–2, 7–6 (7–4) |
| Winner | 2008 | Wimbledon | Grass | Samantha Stosur | Katarina Srebotnik Mike Bryan | 7–5, 6–4 |
| Winner | 2009 | French Open (2) | Clay | Liezel Huber | Vania King Marcelo Melo | 5–7, 7–6 (7–5) , [10–7] |