2010 Southeastern Conference football season Week Five Week Five

| Date_ | Time_ | Visiting_team | Home_team | Site | Broadcast | Result_ | Attendance |
|---|---|---|---|---|---|---|---|
| October 2 | 12:00pm | Louisiana-Monroe | #10 Auburn | Jordan-Hare Stadium • Auburn, AL | ESPNU | W 52–3 | 80759 |
| October 2 | 12:00pm | Alcorn State | Mississippi State | Davis Wade Stadium • Starkville, MS | FSN | W 49–16 | 50439 |
| October 2 | 12:00pm | Vanderbilt | Connecticut | Rentschler Field • Storrs, CT | Big East Network | L 21–40 | 40000 |
| October 2 | 12:21pm | Kentucky | Ole Miss | Vaught-Hemingway Stadium • Oxford, MS | SEC Network | MIS 42–35 | 55344 |
| October 2 | 3:30pm | Tennessee | #12 LSU | Tiger Stadium • Baton Rouge, LA | CBS | LSU 16–14 | 92932 |
| October 2 | 4:30pm | Georgia | Colorado | Folsom Field • Boulder, CO | FSN | L 27–29 | 52855 |