1981 VFL season Round 6 Round 6

| Home_team | Home_team_score | Away_team | Away_team_score | Venue | Crowd | Date_ |
|---|---|---|---|---|---|---|
| Carlton | 12.15 (87) | Collingwood | 22.12 (144) | Princes Park | 36506 | 2 May 1981 |
| Richmond | 10.19 (79) | Hawthorn | 23.16 (154) | MCG | 45750 | 2 May 1981 |
| North Melbourne | 27.17 (179) | Fitzroy | 19.12 (126) | Arden Street Oval | 16210 | 2 May 1981 |
| Footscray | 13.13 (91) | Essendon | 12.11 (83) | Western Oval | 19264 | 2 May 1981 |
| South Melbourne | 15.13 (103) | St Kilda | 13.15 (93) | VFL Park | 27172 | 2 May 1981 |
| Geelong | 22.21 (153) | Melbourne | 16.8 (104) | SCG | 11077 | 3 May 1981 |