List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation

| Year_ | City | State_province_dept_etc_ | Country | Notes_ |
|---|---|---|---|---|
| 1525 | Acapulco | Guerrero | Mexico | [4] |
| 1525 | San Salvador | San Salvador | El Salvador | Founded in 1525, rebuilt and changed locations twice afterwards (1528 and 1545) and oldest continuously inhabited European established settlement in El Salvador. |
| 1526 | Acámbaro | Guanajuato | Mexico |  |
| 1526 | Chimaltenango | Chimaltenango | Guatemala |  |
| 1528 | San Cristóbal de las Casas | Chiapas | Mexico | Originally called Villa Real de Chiapa. |
| 1529 | Maracaibo | Zulia | Venezuela |  |
| 1530 | San Blas | Nayarit | Mexico | By Nuño Beltrán [5] |
| 1531 | Puebla | Puebla | Mexico | by Fr. Toribio de Benavente (Motolinía) on 16 April [6] |
| 1532 | Oaxaca | Oaxaca | Mexico |  |
| 1532 | Piura | Piura | Peru |  |