1981 Houston Oilers season Regular season Schedule

| Week | Date_ | Opponent | Result_ | Attendance_ |
|---|---|---|---|---|
| 11 | November 15, 1981 | at Kansas City Chiefs | L 23–10 | 73984 |
| 12 | November 22, 1981 | New Orleans Saints | L 27–24 | 49581 |
| 13 | November 29, 1981 | Atlanta Falcons | L 31–27 | 40201 |
| 14 | December 3, 1981 | Cleveland Browns | W 17–13 | 44502 |
| 15 | December 13, 1981 | at San Francisco 49ers | L 28–6 | 55707 |
| 16 | December 20, 1981 | Pittsburgh Steelers | W 21–20 | 41056 |