2000 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Location_ | Record | Attendance |
|---|---|---|---|---|---|---|
| 1 | September 3, 2000 | Tennessee Titans | W 16–13 | Ralph Wilson Stadium | 1-0 | 72492 |
| 2 | September 10, 2000 | Green Bay Packers | W 27–18 | Ralph Wilson Stadium | 2-0 | 72722 |
| 3 | September 17, 2000 | at New York Jets | L 27–14 | The Meadowlands | 2-1 | 77884 |
| 4 | Bye | Bye | Bye | Bye | Bye | Bye |
| 5 | October 1, 2000 | Indianapolis Colts | L 18–16 | Ralph Wilson Stadium | 2-2 | 72617 |
| 6 | October 8, 2000 | at Miami Dolphins | L 22–13 | Pro Player Stadium | 2-3 | 73901 |
| 7 | October 15, 2000 | San Diego Chargers | W 27–24 | Ralph Wilson Stadium | 3-3 | 72351 |