2008 CAF Confederation Cup Second Round of 16 Second Round of 16

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Etoile du Sahel | 2–0 | Espérance | 2–0 | 0–0 |
| Club Africain | 0–0 (5–3 Pk ) | Djoliba | 0–0 | 0–0 |
| Platinum Stars | 2–4 | CS Sfaxien | 2–2 | 0–2 |
| JS Kabylie | 2–1 | Les Astres FC | 1–1 | 1–0 |
| Mamelodi Sundowns | 1–2 | Haras El Hodood | 1–0 | 0–2 |
| Olympique Khouribga | 2–2( a ) | Al-Merrikh | 2–2 | 0–0 |
| Inter Luanda | 3–2 | Mount Cameroon FC | 2–1 | 1–1 |
| Al Ittihad Tripolil | 3–4 | Asante Kotoko | 2–1 | 1–3 |