1980 San Francisco 49ers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 7, 1980 | at New Orleans Saints | W 26-23 | 58621 |
| 2 | September 14, 1980 | St. Louis Cardinals | W 24-21 | 49999 |
| 3 | September 21, 1980 | at New York Jets | W 37-27 | 50608 |
| 4 | September 28, 1980 | Atlanta Falcons | L 20-17 | 56518 |
| 5 | October 5, 1980 | at Los Angeles Rams | L 48-26 | 62188 |
| 6 | October 12, 1980 | at Dallas Cowboys | L 59-14 | 63399 |
| 7 | October 19, 1980 | Los Angeles Rams | L 31-17 | 55360 |
| 8 | October 26, 1980 | Tampa Bay Buccaneers | L 24-23 | 51925 |
| 9 | November 2, 1980 | at Detroit Lions | L 17-13 | 78845 |