List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation

| Year_ | City | State_province_dept_etc_ | Country | Notes_ |
|---|---|---|---|---|
| 1508 | Caparra | Puerto Rico | United States | Abandoned in 1521 with the removal of the capital to San Juan. |
| 1510 | Santa Maria la Antigua del Darien | Urabá | Colombia | First city founded by Europeans on the continent of South America. |
| 1510 | Nombre de Dios | Colon | Panama | Oldest continuously inhabited European established settlement in Panama. |
| 1511 | Baracoa | Guantánamo | Cuba | Oldest continuously inhabited European established settlement in Cuba, former capital of Cuba. |
| 1514 | Santiago | Santiago | Cuba |  |
| 1515 | Havana | Havana | Cuba |  |
| 1519 | La Villa Rica de la Vera Cruz, (Veracruz) | Veracruz | Mexico | Oldest continuously inhabited European established settlement in Mexico. |
| 1519 | Panama City | Panamá | Panama | First European established city on the Pacific Coast of the Americas |