2008 San Francisco Giants season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 13 | @ Padres | 7–0 | Young (5–6) | 31015 | 67–81 |
| September 14 | @ Padres | 8–6 (10) | Hayhurst (0–2) | 25476 | 68–81 |
| September 15 | @ D-backs | 3–1 | Hennessey (1–2) | 25969 | 68–82 |
| September 16 | @ D-backs | 2–0 | Cain (8–13) | 33195 | 68–83 |
| September 17 | @ D-backs | 7–6 | Sánchez (9–11) | 22618 | 68–84 |
| September 18 | @ D-backs | 3–2 | Lincecum (17–4) | 34323 | 68–85 |
| September 19 | @ Dodgers | 7–1 | Maddux (7–13) | 55589 | 69–85 |
| September 20 | @ Dodgers | 10–7 | Walker (4–8) | 55724 | 69–86 |
| September 21 | @ Dodgers | 1–0 (10) | Saito (4–4) | 55294 | 70–86 |
| September 23 | Rockies | 9–4 | Lincecum (17–5) | 33922 | 70–87 |
| September 24 | Rockies | 15–6 | Sánchez (9–12) | 31942 | 70–88 |
| September 25 | Rockies | 3–1 | Zito (10–17) | 31857 | 70–89 |