1981 Toronto Blue Jays season Game log May

| Date_ | Opponent | Score | Loss | Record |
|---|---|---|---|---|
| May 10 | Red Sox | 9–5 (10) | Jackson (0–1) | 9–18 |
| May 11 | Red Sox | 7–6 | Willis (0–3) | 9–19 |
| May 12 | Orioles | 5–2 | Palmer (1–1) | 10–19 |
| May 13 | Orioles | 4–0 | Bomback (3–3) | 10–20 |
| May 14 | Orioles | 10–0 | Clancy (1–3) | 10–21 |
| May 15 | @ Indians | 3–0 | Leal (2–4) | 10–22 |
| May 16 | @ Indians | 4–1 | Garland (2–3) | 11–22 |
| May 17 | @ Indians | 1–0 | Stieb (3–4) | 11–23 |
| May 17 | @ Indians | 2–1 (10) | Jackson (0–2) | 11–24 |
| May 18 | White Sox | 7–2 | Bomback (3–4) | 11–25 |
| May 19 | White Sox | 9–5 | Hoyt (3–1) | 12–25 |
| May 20 | White Sox | 6–5 | McLaughlin (0–2) | 12–26 |
| May 22 | @ Athletics | 6–2 | Stieb (3–5) | 12–27 |