1921–22 Manchester United F.C. season First Division First Division

| Date_ | Opponents | H_A | Result_F_A | Scorers | Attendance_ |
|---|---|---|---|---|---|
| 27 August 1921 | Everton | A | 0–5 |  | 30000 |
| 29 August 1921 | West Bromwich Albion | H | 2–3 | Partridge, Robinson | 20000 |
| 3 September 1921 | Everton | H | 2–1 | Harrison, Spence | 25000 |
| 7 September 1921 | West Bromwich Albion | A | 0–0 |  | 15000 |
| 10 September 1921 | Chelsea | A | 0–0 |  | 35000 |
| 17 September 1921 | Chelsea | H | 0–0 |  | 28000 |
| 24 September 1921 | Preston North End | A | 2–3 | Lochhead, Partridge | 25000 |
| 1 October 1921 | Preston North End | H | 1–1 | Spence | 30000 |
| 8 October 1921 | Tottenham Hotspur | A | 2–2 | Sapsford, Spence | 35000 |
| 15 October 1921 | Tottenham Hotspur | H | 2–1 | Sapsford, Spence | 30000 |
| 22 October 1921 | Manchester City | A | 1–4 | Spence | 24000 |