2001 Cleveland Indians season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 22 | Tigers | 11 - 3 | Mlicki (0-2) | 34125 | 11-6 |
| April 24 | Angels | 7 - 2 | Colón (2-2) | 31942 | 11-7 |
| April 25 | Angels | 3 - 1 | Sabathia (2-1) | 31396 | 11-8 |
| April 26 | Angels | 6 - 5 | Hasegawa (1-2) | 29427 | 12-8 |
| April 27 | Rangers | 11 - 9 | Drew (0-1) | 40320 | 12-9 |
| April 28 | Rangers | 7 - 3 | Helling (1-4) | 41147 | 13-9 |
| April 29 | Rangers | 9 - 2 | Davis (2-2) | 40132 | 14-9 |