1978 San Francisco 49ers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 3, 1978 | at Cleveland Browns | L 24-7 | 68973 |
| 2 | September 10, 1978 | Chicago Bears | L 16-13 | 49502 |
| 3 | September 17, 1978 | at Houston Oilers | L 20-19 | 46161 |
| 4 | September 24, 1978 | at New York Giants | L 27-10 | 71536 |
| 5 | October 1, 1978 | Cincinnati Bengals | W 28-12 | 41107 |
| 6 | October 8, 1978 | at Los Angeles Rams | L 27-10 | 59337 |
| 7 | October 15, 1978 | New Orleans Saints | L 14-7 | 37671 |
| 8 | October 22, 1978 | Atlanta Falcons | L 20-17 | 44235 |
| 9 | October 29, 1978 | at Washington Redskins | L 38-20 | 53706 |
| 10 | November 5, 1978 | at Atlanta Falcons | L 21-10 | 55468 |