2007–08 UEFA Cup Round of 16 Round of 16

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Anderlecht | 2–6 | Bayern Munich | 0–5 | 2–1 |
| Rangers | 2–1 | Werder Bremen | 2–0 | 0–1 |
| Bolton Wanderers | 1–2 | Sporting CP | 1–1 | 0–1 |
| Bayer Leverkusen | 3–3 ( a ) | Hamburg | 1–0 | 2–3 |
| Benfica | 1–3 | Getafe | 1–2 | 0–1 |
| Fiorentina | 2–2 (4–2 p ) | Everton | 2–0 | 0–2 ( aet ) |
| Tottenham Hotspur | 1–1 (5–6 p ) | PSV Eindhoven | 0–1 | 1–0 ( aet ) |
| Marseille | 3–3 ( a ) | Zenit St. Petersburg | 3–1 | 0–2 |