2010 Collingwood Football Club season Regular home and away season Regular home and away season

| Round | Date_ | Opponent | Home_Away | Score_Collingwoods_score_is_in_bold | Result_includes_margin | Venue | Position_on_Ladder |
|---|---|---|---|---|---|---|---|
| 1 | Sunday, 28 March 2:10pm | Western Bulldogs | Away | 13.15 (93) - 19.15 (129) | Won by 36 points | Etihad Stadium | 5th |
| 2 | Saturday, 4 April 2:10pm | Melbourne | Home | 12.14 (86) - 12.13 (85) | Won by 1 point | MCG | 5th |
| 3 | Friday, 10 April 7:40pm | St Kilda | Away | 10.9 (69) - 4.17 (41) | Lost by 28 points | Etihad Stadium | 7th |
| 4 | Saturday, 18 April 7:10pm | Hawthorn | Home | 17.21 (123) - 8.11 (59) | Won by 64 points | MCG | 6th |
| 5 | Sunday, 25 April 2:40pm | Essendon | Home | 18.12 (120) - 8.7 (55) | Won by 65 points | MCG | 3rd |