2010 Big East Conference football season Week Two Week Two

| Date_ | Time_ | Visiting_team | Home_team | Site | Broadcast | Result_ | Attendance |
|---|---|---|---|---|---|---|---|
| September 11 | 3:30pm | Eastern Kentucky | Louisville | Papa John`s Cardinal Stadium • Louisville, KY | Big East Network | W 23–13 | 51427 |
| September 11 | 7:00pm | Syracuse | Washington | Husky Stadium • Seattle, WA | FSN Northwest | L 20–41 | 62418 |