1981 Philadelphia Eagles season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 6, 1981 | at New York Giants | W 24–10 | 72459 |
| 2 | September 13, 1981 | New England Patriots | W 13–3 | 71089 |
| 3 | September 17, 1981 | at Buffalo Bills | W 20–14 | 78331 |
| 4 | September 27, 1981 | Washington Redskins | W 36–13 | 70664 |
| 5 | October 5, 1981 | Atlanta Falcons | W 16–13 | 71488 |
| 6 | October 11, 1981 | at New Orleans Saints | W 31–14 | 52728 |
| 7 | October 18, 1981 | at Minnesota Vikings | L 35–23 | 45459 |
| 8 | October 25, 1981 | Tampa Bay Buccaneers | W 20–10 | 70714 |
| 9 | November 1, 1981 | Dallas Cowboys | L 17–14 | 72111 |
| 10 | November 8, 1981 | at St. Louis Cardinals | W 52–10 | 48421 |