1981 New England Patriots season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 11 | November 15, 1981 | New York Jets | L 17–6 | 45342 |
| 12 | November 22, 1981 | at Buffalo Bills | L 20–17 | 71593 |
| 13 | November 29, 1981 | St. Louis Cardinals | L 27–20 | 39946 |
| 14 | December 6, 1981 | at Miami Dolphins | L 24–14 | 50421 |
| 15 | December 13, 1981 | Buffalo Bills | L 19–10 | 42549 |
| 16 | December 20, 1981 | at Baltimore Colts | L 23–21 | 17073 |