1988 San Diego Chargers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 4, 1988 | at Los Angeles Raiders | L 24–13 | 39029 |
| 2 | September 11, 1988 | at Denver Broncos | L 34–3 | 75359 |
| 3 | September 18, 1988 | Seattle Seahawks | W 17–6 | 44449 |
| 4 | September 25, 1988 | at Kansas City Chiefs | W 24–23 | 45498 |
| 5 | October 2, 1988 | Denver Broncos | L 12–0 | 55763 |
| 6 | October 9, 1988 | New Orleans Saints | L 23–17 | 42693 |
| 7 | October 16, 1988 | at Miami Dolphins | L 31–28 | 58972 |
| 8 | October 23, 1988 | Indianapolis Colts | L 16–0 | 37722 |
| 9 | October 30, 1988 | at Seattle Seahawks | L 17–14 | 59641 |
| 10 | November 6, 1988 | Los Angeles Raiders | L 13–3 | 55134 |