2008 Cleveland Indians season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 23 | @ Royals | Postponed (rain) Rescheduled for April 24 | Postponed (rain) Rescheduled for April 24 | Postponed (rain) Rescheduled for April 24 | Postponed (rain) Rescheduled for April 24 |
| April 24 | @ Royals | 9–6 | Tomko (1–3) | 11637 | 9–12 |
| April 24 | @ Royals | 2–0 | Bannister (3–2) | 11637 | 10–12 |
| April 25 | Yankees | 6–4 | Pettitte (3–2) | 31467 | 11–12 |
| April 26 | Yankees | 4–3 | Ohlendorf (0–1) | 35765 | 12–12 |
| April 27 | Yankees | 1–0 | Sabathia (1–4) | 31598 | 12–13 |
| April 28 | Yankees | 5–2 | Laffey (0–1) | 20689 | 12–14 |
| April 29 | Mariners | 7–2 | Betancourt (1–1) | 13827 | 12–15 |
| April 30 | Mariners | 8–3 | Washburn (1–4) | 15279 | 13–15 |