2008 Houston Astros season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 26 | @ Cardinals | 3–4 | Borkowski (0–1) | 43040 | 12–13 |
| April 27 | @ Cardinals | 1–5 | Backe (1–3) | 44222 | 12–14 |
| April 28 | @ D-backs | 3–5 | Sampson (1–3) | 19868 | 12–15 |
| April 29 | @ D-backs | 6–4 | González (1–2) | 20241 | 13–15 |
| April 30 | @ D-backs | 7–8 | Borkowski (0–2) | 21519 | 13–16 |