2000 Indianapolis Colts season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Record | Game_Site | TV_Time | Attendance |
|---|---|---|---|---|---|---|---|
| 1 | September 3, 2000 | at Kansas City Chiefs | W 27–14 | 1–0 | Arrowhead Stadium | CBS 1:00pm | 78357 |
| 2 | September 10, 2000 | Oakland Raiders | L 31–38 | 1–1 | RCA Dome | CBS 1:00pm | 56769 |
| 3 | Bye | Bye | Bye | Bye | Bye | Bye | Bye |
| 4 | September 25, 2000 | Jacksonville Jaguars | W 43–14 | 2–1 | RCA Dome | ABC 9:00pm | 56816 |
| 5 | October 1, 2000 | at Buffalo Bills | W 18–16 | 3–1 | Ralph Wilson Stadium | CBS 1:00pm | 72617 |
| 6 | October 8, 2000 | at New England Patriots | L 16–24 | 3–2 | Foxboro Stadium | CBS 1:00pm | 60292 |
| 7 | October 15, 2000 | at Seattle Seahawks | W 37–24 | 4–2 | Husky Stadium | CBS 4:15pm | 63593 |