2008 San Diego Chargers season Regular season Regular season

| Week | Date_ | Time_ | Opponent | Result_ | Game_site | NFL_Recap | Record |
|---|---|---|---|---|---|---|---|
| 1 | September 7, 2008 | 1:15 p.m. | Carolina Panthers | L 24–26 | Qualcomm Stadium | Recap | 0–1 |
| 2 | September 14, 2008 | 1:15 p.m. | at Denver Broncos | L 38–39 | Invesco Field | Recap | 0–2 |
| 3 | September 22, 2008 | 5:30 p.m. | New York Jets | W 48–29 | Qualcomm Stadium | Recap | 1–2 |
| 4 | September 28, 2008 | 1:05 p.m. | at Oakland Raiders | W 28–18 | Oakland-Alameda County Coliseum | Recap | 2–2 |
| 5 | October 5, 2008 | 10 a.m. | at Miami Dolphins | L 17–10 | Dolphin Stadium | Recap | 2–3 |
| 6 | October 12, 2008 | 5:15 p.m. | New England Patriots | W 30–10 | Qualcomm Stadium | Recap | 3–3 |