List of Houston Astros Opening Day starting pitchers Pitchers Pitchers

| Season | Pitcher | Decision | Final_score | Opponent | Location_ |
|---|---|---|---|---|---|
| 1994 | Pete Harnisch (2) | ND (W) | 6–5 | Montreal Expos | Astrodome |
| 1995 | Doug Drabek (2) | W | 10–2 | San Diego Padres | Jack Murphy Stadium |
| 1996 | Shane Reynolds | L | 3–4 | Los Angeles Dodgers | Astrodome |
| 1997* | Shane Reynolds (2) | W | 2–1 | Atlanta Braves | Astrodome |
| 1998* | Shane Reynolds (3) | ND (L) | 4–9 | San Francisco Giants | Astrodome |
| 1999* | Shane Reynolds (4) | W | 4–2 | Chicago Cubs | Astrodome |
| 2000 | Shane Reynolds (5) | W | 5–2 | Pittsburgh Pirates | Three Rivers Stadium |
| 2001* | Scott Elarton | W | 11–3 | Milwaukee Brewers | Enron Field |
| 2002 | Wade Miller | L | 3–9 | Milwaukee Brewers | Astros Field |
| 2003 | Roy Oswalt | W | 10–4 | Colorado Rockies | Minute Maid Park |