1965 St. Louis Cardinals (NFL) season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 19, 1965 | at Philadelphia Eagles | L 34-27 | 54260 |
| 2 | September 26, 1965 | at Cleveland Browns | W 49-13 | 80161 |
| 3 | October 4, 1965 | Dallas Cowboys | W 20-13 | 32034 |
| 4 | October 10, 1965 | at Washington Redskins | W 37-16 | 50205 |
| 5 | October 17, 1965 | at Pittsburgh Steelers | W 20-7 | 31085 |
| 6 | October 24, 1965 | Washington Redskins | L 24-20 | 32228 |
| 7 | October 31, 1965 | at New York Giants | L 14-10 | 62807 |
| 8 | November 7, 1965 | Pittsburgh Steelers | W 21-17 | 31899 |
| 9 | November 14, 1965 | at Chicago Bears | L 34-13 | 45663 |
| 10 | November 21, 1965 | New York Giants | L 28-15 | 31704 |