USA Today All-USA high school football team 2011 team Second Team Defense

| Player | Position_ | School | Hometown | College |
|---|---|---|---|---|
| Eddie Goldman | Defensive line | Friendship Collegiate Charter School | Washington, D.C. | Florida State |
| Caleb Gulledge | Defensive line | Prattville High School | Prattville, Alabama | Alabama |
| Robert Nkemdiche ‡ | Defensive line | Grayson High School | Loganville, Georgia | Mississippi |
| Benetton Fonua | Linebacker | Kahuku High School | Kahuku, Hawaii | Hawai ʻ i |
| DeMarkus Lathan ‡ | Linebacker | Longview High School | Longview, Texas | Tarleton State |
| Justin Lyles | Linebacker | Phoebus High School | Hampton, Virginia | Concord (WV) |
| Antonio Morrison | Linebacker | Bolingbrook High School | Bolingbrook, Illinois | Florida |
| Jabari Ruffin | Linebacker | Downey High School | Downey, California | Southern California |
| Ronald Darby | Defensive back | Potomac High School | Oxon Hill, Maryland | Florida State |
| Yuri Wright | Defensive back | Don Bosco Preparatory High School | Ramsey, New Jersey | Colorado |