2005 Chicago White Sox season Game log April

| Date_ | Opponent | Score | Loss | Time_ | Att_ | Record |
|---|---|---|---|---|---|---|
| April 4 | Indians | 1–0 | Westbrook (0–1) | 1:51 | 38141 | 1–0 |
| April 6 | Indians | 4–3 | Wickman (0–1) | 2:55 | 10520 | 2–0 |
| April 7 | Indians | 5 – 11 (11) | Vizcaíno (0–1) | 3:56 | 10800 | 2–1 |
| April 8 | @ Twins | 5–1 | Lohse (0–1) | 2:46 | 48764 | 3–1 |
| April 9 | @ Twins | 8–5 | Radke (0–2) | 2:37 | 41533 | 4–1 |
| April 10 | @ Twins | 2–5 | Buehrle (1–1) | 2:29 | 28089 | 4–2 |
| April 11 | @ Indians | 2–1 | Millwood (0–1) | 2:39 | 42461 | 5–2 |
| April 13 | @ Indians | 5 – 4 (10) | Howry (0–1) | 2:54 | 14410 | 6–2 |
| April 14 | @ Indians | 6–8 | Hernández (1–1) | 3:25 | 12470 | 6–3 |