2000–01 Sheffield Wednesday F.C. season Football League First Division Football League First Division

| Date_ | Opponent | Venue | Result_ | Attendance |
|---|---|---|---|---|
| 13 August 2000 | Wolverhampton Wanderers | A | 1-1 | 19086 |
| 19 August 2000 | Huddersfield Town | H | 2-3 | 22704 |
| 26 August 2000 | Grimsby Town | A | 1-0 | 7755 |
| 28 August 2000 | Blackburn Rovers | H | 1-1 | 15646 |
| 9 September 2000 | Wimbledon | H | 0-5 | 15856 |
| 13 September 2000 | Nottingham Forest | H | 0-1 | 15700 |
| 16 September 2000 | Tranmere Rovers | A | 0-2 | 9352 |
| 23 September 2000 | Preston North End | H | 1-3 | 17379 |
| 30 September 2000 | Gillingham | A | 0-2 | 9099 |
| 8 October 2000 | West Bromwich Albion | H | 1-2 | 15338 |
| 14 October 2000 | Portsmouth | A | 1-2 | 13376 |
| 17 October 2000 | Burnley | A | 0-1 | 16372 |