2010–11 TFF First League Managerial changes After the start of the season

| Team | Outgoing_manager | Manner_of_departure | Date_of_vacancy | Replaced_by | Date_of_appointment |
|---|---|---|---|---|---|
| Karşıyaka | Erdoğan Arıca | Mutual consent | 01 Sep 2010 | Kemal Kılıç | 07 Sep 2010 |
| Adanaspor | Kemal Kılıç | Mutual consent | 06 Sep 2010 | Cemal Gürsel Menteşe | 14 Sep 2010 |
| Gaziantep BB | Cemal Gürsel Menteşe | Mutual consent | 08 Sep 2010 | Erol Azgın | 08 Sep 2010 |
| Altay | Ercan Ertemçöz | Mutual consent | 05 Oct 2010 | Coşkun Demirbakan | 06 Oct 2010 |
| Giresunspor | Hüsnü Özkara | Mutual consent | 10 Oct 2010 | Bahri Kaya | 14 Oct 2010 |
| Mersin İdmanyurdu | Yüksel Yeşilova | Mutual consent | 17 Oct 2010 | Nurullah Sağlam | 20 Oct 2010 |
| Diyarbakırspor | Suat Kaya | Resignation | 23 Oct 2010 | Engin Korukır | 03 Nov 2010 |