1969 Buffalo Bills season Season schedule Season schedule

| Date_ | Opponent | Score | Result_ | Record | Attendance |
|---|---|---|---|---|---|
| September 14 | New York Jets | 33-19 | Loss | 0–1 | 46165 |
| September 21 | Houston Oilers | 21–17 | Loss | 0–2 | 40146 |
| September 28 | Denver Broncos | 41-28 | Win | 1–2 | 40302 |
| October 5 | Houston Oilers | 28-14 | Loss | 1–3 | 46485 |
| October 11 | Boston Patriots | 23-16 | Win | 2–3 | 46201 |
| October 19 | at Oakland Raiders | 50-21 | Loss | 2–4 | 54418 |
| October 26 | at Miami Dolphins | 24-6 | Loss | 2–5 | 39837 |
| November 2 | Kansas City Chiefs | 29-7 | Loss | 2–6 | 45844 |
| November 9 | at New York Jets | 16-6 | Loss | 2–7 | 62680 |
| November 16 | Miami Dolphins | 28-3 | Win | 3–7 | 32686 |
| November 23 | at Boston Patriots | 35-21 | Loss | 3–8 | 25584 |