2005 New York Yankees season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record | Boxscore |
|---|---|---|---|---|---|---|
| April 16 | @ Orioles | 6–7 | Gordon (0–2) | 48598 | 4–7 | L3 |
| April 17 | @ Orioles | 4–8 | Brown (0–1) | 47883 | 4–8 | L4 |
| April 18 | Devil Rays | 19–8 | Bell (1–1) | 35282 | 5–8 | W1 |
| April 19 | Devil Rays | 2–6 | Johnson (1–1) | 45802 | 5–9 | L1 |
| April 20 | @ Blue Jays | 11–2 | Lilly (0–2) | 22838 | 6–9 | W1 |
| April 21 | @ Blue Jays | 4–3 | Chacín (3–1) | 23178 | 7–9 | W2 |
| April 22 | Rangers | 3–5 | Brown (0–2) | 42710 | 7–10 | L1 |
| April 23 | Rangers | 2–10 | Wright (2–2) | 44731 | 7–11 | L2 |
| April 24 | Rangers | 11–1 | Astacio (1–2) | 42732 | 8–11 | W1 |
| April 26 | Angels | 12–4 | Colon (3–2) | 36328 | 9–11 | W2 |
| April 27 | Angels | 1–5 | Mussina (1–2) | 37934 | 9–12 | L1 |