1981 Houston Oilers season Regular season Schedule

| Week | Date_ | Opponent | Result_ | Attendance_ |
|---|---|---|---|---|
| 1 | September 6, 1981 | at Los Angeles Rams | W 27–20 | 63198 |
| 2 | September 13, 1981 | at Cleveland Browns | W 9–3 | 79483 |
| 3 | September 20, 1981 | Miami Dolphins | L 16–10 | 47379 |
| 4 | September 27, 1981 | at New York Jets | L 33–17 | 50309 |
| 5 | October 4, 1981 | Cincinnati Bengals | W 17–10 | 44350 |
| 6 | October 11, 1981 | Seattle Seahawks | W 35–17 | 42671 |
| 7 | October 18, 1981 | at New England Patriots | L 38–10 | 60474 |
| 8 | October 26, 1981 | at Pittsburgh Steelers | L 26–13 | 52732 |
| 9 | November 1, 1981 | at Cincinnati Bengals | L 34–21 | 54736 |
| 10 | November 8, 1981 | Oakland Raiders | W 17–16 | 45519 |