2008 Houston Astros season Game log May

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| May 27 | @ Cardinals | 8–2 | Looper (6–4) | 41104 | 30–23 |
| May 28 | @ Cardinals | 1–6 | Rodríguez (1–1) | 41114 | 30–24 |
| May 29 | @ Cardinals | 2–3 | Oswalt (4–5) | 41786 | 30–25 |
| May 30 | @ Brewers | 5–1 | Backe (4–6) | 32039 | 30–26 |
| May 31 | @ Brewers | 4–1 | Moehler (2–2) | 42913 | 30–27 |