2010 MLS SuperDraft Round two Round two

| Pick_ | MLS_Team | Player | Position_ | Affiliation |
|---|---|---|---|---|
| 17 | Philadelphia Union | Toni Ståhl | Midfielder | University of Connecticut |
| 18 | New York Red Bulls | Tim Ream | Defender | Saint Louis University Chicago Fire Premier |
| 19 | San Jose Earthquakes | Michael Thomas | Midfielder | University of Notre Dame Kansas City Brass |
| 20 | Kansas City Wizards | Korede Aiyegbusi | Defender | North Carolina State University Cary Clarets |
| 21 | FC Dallas | * Andrew Wiedeman | Forward | University of California NorCal Lamorinda United |
| 22 | Colorado Rapids | Andre Akpan | Forward | Harvard University Chicago Fire Premier |
| 23 | Colorado Rapids | Ross LaBauex | Midfielder | University of Virginia Chicago Fire Premier |
| 24 | Toronto FC | *Zachary Herold | Defender | West Pines United Club |