2006 CFL Draft Round four Round four

| Pick_ | CFL_Team | Player | Position_ | College |
|---|---|---|---|---|
| 26 | Edmonton Eskimos (via Hamilton) | Andrew Brown | LB | Lafayette College |
| 27 | Calgary Stampeders (via Winnipeg) | Riley Clayton | OL | Manitoba |
| 28 | Hamilton Tiger-Cats (via Ottawa) | Chris Sutherland | OL | Saskatchewan |
| 29 | Saskatchewan Roughriders | Peter Hogarth | OL | McMaster |
| 30 | Calgary Stampeders | Gerald Commissiong | RB | Stanford |
| 31 | Toronto Argonauts | Obed Cétoute | WR | Central Michigan |
| 32 | Montreal Alouettes (via BC) | Ivan Birungi | WR | Acadia |
| 33 | Montreal Alouettes | Adrian Davis | DL | Marshall |