Swiss International Air Lines destinations Destinations Destinations

| City | Country | IATA | ICAO | Airport |
|---|---|---|---|---|
| San Francisco | United States | SFO | KSFO | San Francisco Airport |
| Santiago | Chile | SCL | SCEL | Comodoro Arturo Benitez Airport |
| São Paulo | Brazil | GRU | SBGR | Guarulhos Airport |
| Sarajevo | Bosnia and Herzegovina | SJJ | LQSA | Butmir Airport |
| Seattle | United States | SEA | KSEA | Sea-Tac Airport |
| Shanghai | China | PVG | ZSPD | Pudong Airport |
| Singapore | Singapore | SIN | WSSS | Changi Airport |
| Skopje | Republic of Macedonia | SKP | LWSK | Alexander the Great Airport |
| Sofia | Bulgaria | SOF | LBSF | Vrazhdebna Airport |
| Stockholm | Sweden | ARN | ESSA | Arlanda Airport |
| Stuttgart | Germany | STR | EDDS | Echterdingen Airport |
| Taipei | Taiwan | TPE | RCTP | Taoyuan Airport |
| Tehran | Iran | IKA | OIIE | Imam Khomeini Airport |
| Tel Aviv | Israel | TLV | LLBG | Ben Gurion Airport |
| Thessaloniki | Greece | SKG | LGTS | Macedonia Airport |