1981 Kansas City Chiefs season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 6, 1981 | at Pittsburgh Steelers | W 37–33 | 53305 |
| 2 | September 13, 1981 | Tampa Bay Buccaneers | W 19–10 | 50555 |
| 3 | September 20, 1981 | San Diego Chargers | L 42–31 | 63866 |
| 4 | September 27, 1981 | at Seattle Seahawks | W 20–14 | 59255 |
| 5 | October 4, 1981 | at New England Patriots | L 33–17 | 55931 |
| 6 | October 11, 1981 | Oakland Raiders | W 27–0 | 76543 |
| 7 | October 18, 1981 | Denver Broncos | W 28–14 | 74672 |
| 8 | October 25, 1981 | at Oakland Raiders | W 28–17 | 42914 |
| 9 | November 1, 1981 | at San Diego Chargers | L 22–20 | 51307 |
| 10 | November 8, 1981 | Chicago Bears | L 16–13 | 60605 |