1981 African Cup of Champions Clubs Second round Second round

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Costa do Sol | 2-6 | Nchanga Rangers | 1-3 | 1-3 |
| Silures | 3-4 | AS Vita Club | 0-1 | 3-3 |
| FC Horsed | 1-4 | JE Tizi-Ouzou | 1-2 | 0-2 1 |
| Canon Yaoundé | 1-3 | ASEC Mimosas | 0-0 | 1-3 |
| Asante Kotoko | 2-4 | AS Kaloum Star | 1-0 | 1-3 |
| Shooting Stars FC | 1-5 | Dynamos FC | 1-2 | 0-3 |
| US Mbila Nzambi | 2-1 | OC Agaza | 2-0 | 0-1 |
| Nile Breweries FC | 2-5 | Al-Ahly | 2-0 | 0-5 |