1990 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Record | Game_Site | Attendance |
|---|---|---|---|---|---|---|
| 1 | September 9, 1990 | Indianapolis Colts | W 26–10 | 1–0 | Rich Stadium | 78899 |
| 2 | September 16, 1990 | at Miami Dolphins | L 7–30 | 1–1 | Joe Robbie Stadium | 68142 |
| 3 | September 24, 1990 | at New York Jets | W 30–7 | 2–1 | Giants Stadium | 69927 |
| 4 | September 30, 1990 | Denver Broncos | W 29–28 | 3–1 | Rich Stadium | 74393 |
| 5 | October 7, 1990 | Los Angeles Raiders | W 38–24 | 4–1 | Rich Stadium | 80076 |
| 6 | Bye | Bye | Bye | Bye | Bye | Bye |
| 7 | October 21, 1990 | New York Jets | W 30–27 | 5–1 | Rich Stadium | 79002 |
| 8 | October 28, 1990 | at New England Patriots | W 27–10 | 6–1 | Sullivan Stadium | 51959 |