1972 Buffalo Bills season NFL Draft NFL Draft

| Round | Pick | Player | Position_ | School_Club_Team |
|---|---|---|---|---|
| 1 | 1 | Walt Patulski | Defensive end | Notre Dame |
| 2 | 27 | Reggie McKenzie | Offensive guard | Michigan |
| 4 | 79 | Randy Jackson | Running back | Wichita State |
| 5 | 105 | Leon Garror | Defensive back | Alcorn State |
| 5 | 108 | Bob Penchion | Offensive guard | Alcorn State |
| 8 | 183 | Paul Gibson | Wide receiver | Texas El-Paso |
| 10 | 235 | Maurice Tyler | Defensive back | Morgan State |
| 13 | 313 | Eddie Moss | Running back | Southeast Missouri State |