1980–81 FA Cup Fifth Round Proper Fifth Round Proper

| Tie_no | Home_team | Score | Away_team | Date_ |
|---|---|---|---|---|
| 1 | Southampton | 0–0 | Everton | 14 February 1981 |
| Replay | Everton | 1–0 | Southampton | 17 February 1981 |
| 2 | Nottingham Forest | 2–1 | Bristol City | 14 February 1981 |
| 3 | Wolverhampton Wanderers | 3–1 | Wrexham | 14 February 1981 |
| 4 | Middlesbrough | 2–1 | Barnsley | 14 February 1981 |
| 5 | Ipswich Town | 2–0 | Charlton Athletic | 14 February 1981 |
| 6 | Newcastle United | 1–1 | Exeter City | 14 February 1981 |
| Replay | Exeter City | 4–0 | Newcastle United | 18 February 1981 |
| 7 | Tottenham Hotspur | 3–1 | Coventry City | 14 February 1981 |
| 8 | Peterborough United | 0–1 | Manchester City | 14 February 1981 |