List of people in Playboy 2000–09 2006 2006

| Date_ | Centerfold_model | Interview_subject | _20_Questions | Pictorials |
|---|---|---|---|---|
| 9-06 | Janine Habeck | Michael D. Brown | Eva Longoria | The Girls Next Door , Natalie Reid |
| 10-06 | Jordan Monroe | Ludacris | Johnny Knoxville | Girls of the Big 12 , Christine Dolce |
| 11-06 | Sarah Elizabeth | Arianna Huffington | Tenacious D | Mercedes McNab, Girls of Hawaiian Tropic |
| 12-06 | Kia Drayton | Dixie Chicks | Samuel L. Jackson | Cindy Margolis, Danielle Lloyd |