1980–81 FA Cup Third round proper Third round proper

| Tie_no | Home_team | Score | Away_team | Date_ |
|---|---|---|---|---|
| Replay | Bristol City | 2–0 | Derby County | 7 January 1981 |
| 10 | Everton | 2–0 | Arsenal | 3 January 1981 |
| 11 | Ipswich Town | 1–0 | Aston Villa | 3 January 1981 |
| 12 | Newcastle United | 2–1 | Sheffield Wednesday | 3 January 1981 |
| 13 | Manchester City | 4–0 | Crystal Palace | 3 January 1981 |
| 14 | Queens Park Rangers | 0–0 | Tottenham Hotspur | 3 January 1981 |
| Replay | Tottenham Hotspur | 3–1 | Queens Park Rangers | 7 January 1981 |
| 15 | Barnsley | 2–1 | Torquay United | 3 January 1981 |
| 16 | Maidstone United | 2–4 | Exeter City | 3 January 1981 |
| 17 | West Ham United | 1–1 | Wrexham | 3 January 1981 |
| Replay | Wrexham | 0–0 | West Ham United | 6 January 1981 |
| Replay | Wrexham | 1–0 | West Ham United | 19 January 1981 |