List of people in Playboy 2000–09 2001 2001

| Date_ | Cover_model | Centerfold_model | _20_Questions | Pictorials |
|---|---|---|---|---|
| 1-01 | Gabrielle Reece | Irina Voronina | Carol Alt | Gabrielle Reece |
| 2-01 | Anna Nicole Smith | Lauren Michelle Hill | Sela Ward | Anna Nicole Smith, Surfer Amy Cobb |
| 3-01 | Kylie Bax | Miriam Gonzalez | Traci Lords | Kylie Bax, Girls of golf |
| 4-01 | Irina Voronina | Katie Lohmann | Wyclef Jean | Girls of Hard Rock Hotel and Casino |
| 5-01 | Brooke Burke | Crista Nicole | Mariska Hargitay | Brooke Burke, Temptation Island`s Lola Corwin |
| 6-01 | Brande Roderick | Heather Spytek | Edward Burns | Brande Roderick-PMOY, Naked News |
| 7-01 | Pamela Anderson | Kimberley Stanfield | Johnny Knoxville | Pamela Anderson, Ginger Harrisson |
| 8-01 | Belinda Carlisle | Jennifer Walcott | Jon Bon Jovi | Belinda Carlisle, Girls of Bada Bing |