Charleston Southern Buccaneers Football Charleston Southern vs FBS Schools

| Year_ | FBS_Opponent | Result_ | Opponent_s_Conference | Opponent_s_Head_Coach | Charleston_Southern_s_Head_Coach_ |
|---|---|---|---|---|---|
| 2009 | South Florida Bulls | L, 59-0 | Big East | Jim Leavitt | Jay Mills |
| 2009 | Florida Gators | L, 62-3 | SEC | Urban Meyer | Jay Mills |
| 2008 | Miami Redhawks | L, 38-27 | MAC | Don Treadwell | Jay Mills |
| 2008 | Miami Hurricanes | L, 52-7 | ACC | Randy Shannon | Jay Mills |
| 2007 | Hawaii Warriors | L, 66-10 | WAC | June Jones | Jay Mills |
| 2003 | South Florida Bulls | L, 55-7 | Big East | Jim Leavitt | Jay Mills |
| 2002 | South Florida Bulls | L, 56-6 | Big East | Jim Leavitt | David Dowd |