2010 MLS SuperDraft Round two Round two

| Pick_ | MLS_Team | Player | Position_ | Affiliation |
|---|---|---|---|---|
| 25 | New England Revolution | Seth Sinovic | Defender | Creighton University Chicago Fire Premier |
| 26 | Chicago Fire | Kwame Watson-Siriboe | Defender | University of Connecticut Westchester Flames |
| 27 | Seattle Sounders FC | Mike Seamon | Midfielder | Villanova University |
| 28 | San Jose Earthquakes | Justin Morrow | Defender | University of Notre Dame Chicago Fire Premier |
| 29 | Chicago Fire | Drew Yates | Midfielder | University of Maryland |
| 30 | San Jose Earthquakes | Steven Beitashour | Defender | San Diego State University San Jose Frogs |
| 31 | New England Revolution | Zak Boggs | Forward | University of South Florida Bradenton Academics |