List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation

| Year_ | City | State_province_dept_etc_ | Country | Notes_ |
|---|---|---|---|---|
| 1578 | Fort-Liberté | Nord-Est | Haiti | Originally called Bayaha by the Spanish. Oldest continuously inhabited European established settlement in Haiti. |
| 1578 | Tegucigalpa | Francisco Morazán | Honduras |  |
| 1579 | Coamo | Puerto Rico | United States | Third oldest European settlement in Puerto Rico. In the same area where the Taínos had had their village of Guayama. Coamo became officially a town in 1616, and given the title of villa by Spanish Royal Decree in 1778. |
| 1580 | Buenos Aires |  | Argentina |  |
| 1580 | Santo Domingo Xenacoj | Sacatepéquez | Guatemala |  |
| 1582 | Salta | Salta | Argentina |  |
| 1585 | João Pessoa | Paraíba | Brazil |  |
| 1587 | Concepción del Oro | Zacatecas | Mexico |  |
| 1588 | Corrientes | Corrientes | Argentina |  |
| 1590 | São Cristóvão | Sergipe | Brazil | First capital of Sergipe. Formerly known as Sergipe d`El Rei |
| 1591 | Jiménez del Teul | Zacatecas | Mexico |  |