Mike Bryan Doubles: 25 (15–10) Doubles: 25 (15–10)

| Outcome | Year_ | Championship | Surface | Partner | Opponents | Score |
|---|---|---|---|---|---|---|
| Winner | 2003 | French Open | Clay | Bob Bryan | Paul Haarhuis Yevgeny Kafelnikov | 7–6 (7–3) , 6–3 |
| Runner-up | 2003 | US Open | Hard | Bob Bryan | Jonas Björkman Todd Woodbridge | 7–5, 0–6, 5–7 |
| Runner-up | 2004 | Australian Open | Hard | Bob Bryan | Michaël Llodra Fabrice Santoro | 6–7 (4–7) , 3–6 |
| Runner-up | 2005 | Australian Open | Hard | Bob Bryan | Wayne Black Kevin Ullyett | 4–6, 4–6 |
| Runner-up | 2005 | French Open | Clay | Bob Bryan | Jonas Björkman Max Mirnyi | 6–2, 1–6, 4–6 |
| Runner-up | 2005 | Wimbledon | Grass | Bob Bryan | Stephen Huss Wesley Moodie | 6–7 (4–7) , 3–6, 7–6 (7–2) , 3–6 |