2008 Copa Sudamericana First stage First stage

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Defensor Sporting | 5–4 | Libertad | 2–1 | 3–3 |
| LDU Quito | 5–4 | Bolívar | 4–2 | 1–2 |
| América | 2–1 | Deportivo Cali | 2–0 | 0–1 |
| Ñublense | 1–4 | Sport Áncash | 1–0 | 0–4 |
| Universidad Católica | 6–2 | Olimpia | 4–0 | 2–2 |
| Aragua | 2–3 | Guadalajara | 1–2 | 1–1 |
| San Luis | 5–4 | Deportivo Quito | 3–1 | 2–3 |
| Arsenal | 6–1 | Motagua | 4–0 | 2–1 |
| Independiente | 3–3 (3–5 p ) | Estudiantes | 2–1 | 1–2 |
| Argentinos Juniors | 2–0 | San Lorenzo | 0–0 | 2–0 |
| Atlético Paranaense | 0–0 (4–3 p ) | São Paulo | 0–0 | 0–0 |
| Internacional | 3–3 ( a ) | Grêmio | 1–1 | 2–2 |
| Vasco da Gama | 3–4 | Palmeiras | 3–1 | 0–3 |
| Botafogo | 8–3 | Atlético Mineiro | 3–1 | 5–2 |