Mike Bryan Doubles: 25 (15–10) Doubles: 25 (15–10)

| Outcome | Year_ | Championship | Surface | Partner | Opponents | Score |
|---|---|---|---|---|---|---|
| Winner | 2009 | Australian Open | Hard | Bob Bryan | Mahesh Bhupathi Mark Knowles | 2–6, 7–5, 6–0 |
| Runner-up | 2009 | Wimbledon | Grass | Bob Bryan | Daniel Nestor Nenad Zimonjić | 6–7 (7–9) , 7–6 (7–3) , 6–7 (5–7) , 3–6 |
| Winner | 2010 | Australian Open | Hard | Bob Bryan | Daniel Nestor Nenad Zimonjić | 6–3, 6–7 (5–7) , 6–3 |
| Winner | 2010 | US Open | Hard | Bob Bryan | Rohan Bopanna Aisam-ul-Haq Qureshi | 7–6 (7–5) , 7–6 (7–4) |
| Winner | 2011 | Australian Open | Hard | Bob Bryan | Mahesh Bhupathi Leander Paes | 6–3, 6–4 |
| Winner | 2011 | Wimbledon | Grass | Bob Bryan | Robert Lindstedt Horia Tecău | 6–3, 6–4, 7–6 (7–2) |
| Runner-up | 2012 | Australian Open | Hard | Bob Bryan | Leander Paes Radek Štěpánek | 6–7 (1–7) , 2–6 |