1988 San Francisco 49ers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 4, 1988 | at New Orleans Saints | W 34-33 | 66357 |
| 2 | September 11, 1988 | at New York Giants | W 20-17 | 75943 |
| 3 | September 18, 1988 | Atlanta Falcons | L 17-34 | 60168 |
| 4 | September 25, 1988 | at Seattle Seahawks | W 38-7 | 62382 |
| 5 | October 2, 1988 | Detroit Lions | W 20-13 | 58285 |
| 6 | October 9, 1988 | Denver Broncos | L 13-16 (OT) | 61711 |
| 7 | October 16, 1988 | at Los Angeles Rams | W 24-21 | 65450 |
| 8 | October 24, 1988 (Mon) | at Chicago Bears | L 9-10 | 65293 |
| 9 | October 30, 1988 | Minnesota Vikings | W 24-21 | 60738 |