1961 San Francisco 49ers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 17, 1961 | Washington Redskins | W 35-3 | 43412 |
| 2 | September 24, 1961 | at Green Bay Packers | L 30-10 | 38624 |
| 3 | October 1, 1961 | at Detroit Lions | W 49-0 | 53155 |
| 4 | October 8, 1961 | Los Angeles Rams | W 35-0 | 59004 |
| 5 | October 15, 1961 | at Minnesota Vikings | W 38-24 | 34415 |
| 6 | October 22, 1961 | at Chicago Bears | L 31-0 | 49070 |
| 7 | October 29, 1961 | at Pittsburgh Steelers | L 20-10 | 19686 |
| 8 | November 5, 1961 | Detroit Lions | T 20-20 | 56878 |
| 9 | November 12, 1961 | at Los Angeles Rams | L 17-7 | 63766 |
| 10 | November 19, 1961 | Chicago Bears | W 41-31 | 52972 |