1953 San Francisco 49ers season Schedule Schedule

| Date_ | Visitor | Score | Home | Record | Attendance |
|---|---|---|---|---|---|
| September 27 | Philadelphia Eagles | 31-21 | San Francisco 49ers | 1-0-0 | 25000 |
| October 4 | Los Angeles Rams | 31-30 | San Francisco 49ers | 2-0-0 | 41446 |
| October 11 | San Francisco 49ers | 24-21 | Detroit Lions | 2-1-0 | 56080 |
| October 18 | San Francisco 49ers | 35-28 | Chicago Bears | 3-1-0 | 36909 |
| October 25 | Detroit Lions | 14-10 | San Francisco 49ers | 3-2-0 | 52300 |
| November 1 | Chicago Bears | 24-14 | San Francisco 49ers | 4-2-0 | 26308 |
| November 8 | San Francisco 49ers | 31-27 | Los Angeles Rams | 5-2-0 | 85856 |
| November 15 | San Francisco 49ers | 23-21 | Cleveland Browns | 5-3-0 | 80698 |
| November 22 | San Francisco 49ers | 37-7 | Green Bay Packers | 6-3-0 | 16378 |