2008 New England Patriots season Regular season Regular season

| Week | Kickoff | Date_ | Opponent | Result_ | Record | Game_Site | NFL_com_Recap |
|---|---|---|---|---|---|---|---|
| 7 | 8:30 PM EDT | October 20, 2008 | Denver Broncos | W 41–7 | 4–2 | Gillette Stadium | Recap |
| 8 | 1:00 PM EDT | October 26, 2008 | St. Louis Rams | W 23–16 | 5–2 | Gillette Stadium | Recap |
| 9 | 8:15 PM EST | November 2, 2008 | Indianapolis Colts | L 15–18 | 5–3 | Lucas Oil Stadium | Recap |
| 10 | 1:00 PM EST | November 9, 2008 | Buffalo Bills | W 20–10 | 6–3 | Gillette Stadium | Recap |
| 11 | 8:15 PM EST | November 13, 2008 | New York Jets | L 31–34 (OT) | 6–4 | Gillette Stadium | Recap |
| 12 | 1:00 PM EST | November 23, 2008 | Miami Dolphins | W 48–28 | 7–4 | Dolphin Stadium | Recap |
| 13 | 4:15 PM EST | November 30, 2008 | Pittsburgh Steelers | L 10–33 | 7–5 | Gillette Stadium | Recap |