2006 Oakland Athletics season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 15 | Rangers | 5-4 | Padilla (2-1) | 16186 | 6-6 |
| April 16 | Rangers | 3-5 | Street (1-1) | 21256 | 6-7 |
| April 18 | Tigers | 4-3 | Verlander (1-2) | 16857 | 7-7 |
| April 19 | Tigers | 4-11 | Blanton (1-2) | 18309 | 7-8 |
| April 20 | Tigers | 3-4 | Duchscherer (1-1) | 15489 | 7-9 |
| April 21 | Angels | 5-3 | Romero (1-2) | 19874 | 8-9 |
| April 22 | Angels | 4-5 | Haren (0-2) | 22670 | 8-10 |
| April 23 | Angels | 3-4 | Loaiza (0-3) | 27104 | 8-11 |
| April 24 | @ Rangers | 3-2 | Wilson (1-1) | 23802 | 9-11 |
| April 25 | @ Rangers | 5-6 | Gaudin (0-1) | 25492 | 9-12 |
| April 26 | @ Rangers | 6-4 (10) | Wilson (1-2) | 23756 | 10-12 |
| April 28 | @ Royals | 5-3 | Mays (0-3) | 12203 | 11-12 |