1980 San Francisco 49ers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 10 | November 9, 1980 | at Green Bay Packers | L 23-16 | 54475 |
| 11 | November 16, 1980 | at Miami Dolphins | L 17-13 | 45135 |
| 12 | November 23, 1980 | New York Giants | W 12-0 | 38574 |
| 13 | November 30, 1980 | New England Patriots | W 21-17 | 45254 |
| 14 | December 7, 1980 | New Orleans Saints | W 38-35 | 37949 |
| 15 | December 14, 1980 | at Atlanta Falcons | L 35-10 | 55767 |
| 16 | December 21, 1980 | Buffalo Bills | L 18-13 | 37476 |