2008 Tennessee Titans season Regular season Regular season

| Week | Date_ | Opponent | Result_ | Game_site | Record |
|---|---|---|---|---|---|
| 1 | September 7 | Jacksonville Jaguars | W 17–10 | LP Field | 1–0 |
| 2 | September 14 | at Cincinnati Bengals | W 24–7 | Paul Brown Stadium | 2–0 |
| 3 | September 21 | Houston Texans | W 31–12 | LP Field | 3–0 |
| 4 | September 28 | Minnesota Vikings | W 30–17 | LP Field | 4–0 |
| 5 | October 5 | at Baltimore Ravens | W 13–10 | M&T Bank Stadium | 5–0 |
| 6 | Bye | Bye | Bye | Bye | Bye |
| 7 | October 19 | at Kansas City Chiefs | W 34–10 | Arrowhead Stadium | 6–0 |
| 8 | October 27 | Indianapolis Colts | W 31–21 | LP Field | 7–0 |
| 9 | November 2 | Green Bay Packers | W 19–16 (OT) | LP Field | 8–0 |