1981 Baltimore Colts season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Record | Game_Site | Attendance |
|---|---|---|---|---|---|---|
| 1 | September 6, 1981 | at New England Patriots | W 29–28 | 1–0 | Schaeffer Stadium | 49572 |
| 2 | September 13, 1981 | Buffalo Bills | L 3–35 | 1–1 | Memorial Stadium | 44950 |
| 3 | September 20, 1981 | at Denver Broncos | L 10–28 | 1–2 | Mile High Stadium | 74804 |
| 4 | September 27, 1981 | Miami Dolphins | L 28–31 | 1–3 | Memorial Stadium | 41630 |
| 5 | October 4, 1981 | at Buffalo Bills | L 17–23 | 1–4 | Rich Stadium | 77811 |
| 6 | October 11, 1981 | Cincinnati Bengals | L 19–41 | 1–5 | Memorial Stadium | 33060 |
| 7 | October 18, 1981 | San Diego Chargers | L 14–43 | 1–6 | Memorial Stadium | 41921 |