1981 New Orleans Saints season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 6, 1981 | at Atlanta Falcons | L 27-0 | 57406 |
| 2 | September 13, 1981 | Los Angeles Rams | W 23-17 | 62063 |
| 3 | September 20, 1981 | at New York Giants | L 20-7 | 69814 |
| 4 | September 27, 1981 | at San Francisco 49ers | L 21-14 | 44433 |
| 5 | October 4, 1981 | Pittsburgh Steelers | L 20-6 | 64578 |
| 6 | October 11, 1981 | Philadelphia Eagles | L 31-14 | 52728 |
| 7 | October 18, 1981 | at Cleveland Browns | L 20-17 | 76059 |
| 8 | October 25, 1981 | Cincinnati Bengals | W 17-7 | 46336 |
| 9 | November 1, 1981 | Atlanta Falcons | L 41-10 | 63637 |
| 10 | November 8, 1981 | at Los Angeles Rams | W 21-13 | 61068 |