2008 New York Yankees season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 12 | Rays | Postponed (rain) Rescheduled for September 13 | Postponed (rain) Rescheduled for September 13 | Postponed (rain) Rescheduled for September 13 | Postponed (rain) Rescheduled for September 13 |
| September 13 | Rays | 7-1 | Mussina (17-9) | 54088 | 77-70 |
| September 13 | Rays | 6-5 | Howell (6-1) | 53568 | 78-70 |
| September 14 | Rays | 8-4 | Jackson (11-11) | 54279 | 79-70 |
| September 15 | White Sox | 4-2 | Wassermann (1-2) | 53236 | 80-70 |
| September 16 | White Sox | 6-2 | Pettitte (13-14) | 52558 | 80-71 |
| September 17 | White Sox | 5-1 | Richard (2-5) | 52671 | 81-71 |
| September 18 | White Sox | 9-2 | Vázquez (12-14) | 53152 | 82-71 |
| September 19 | Orioles | 3-2 | Liz (6-6) | 54136 | 83-71 |
| September 20 | Orioles | 1-0 | Miller (0-2) | 54662 | 84-71 |
| September 21 | Orioles | 7-3 | Waters (3-4) | 54610 | 85-71 |
| September 23 | @ Blue Jays | 3-1 | Litsch (12-9) | 27216 | 86-71 |