2008 San Francisco 49ers season Regular season Regular season

| Week | Date_ | Time_PT_ | Opponent | Result_ | Record | Game_site |
|---|---|---|---|---|---|---|
| 8 | October 26, 2008 | 1:15 p.m. | Seattle Seahawks | L 13-34 | 2-6 | Candlestick Park |
| 9 | Bye week | Bye week | Bye week | Bye week | Bye week | Bye week |
| 10 | November 10, 2008 | 5:30 p.m. | at Arizona Cardinals | L 24-29 | 2-7 | University of Phoenix Stadium |
| 11 | November 16, 2008 | 1:05 p.m. | St. Louis Rams | W 35-16 | 3-7 | Candlestick Park |
| 12 | November 23, 2008 | 10 a.m. | at Dallas Cowboys | L 22-35 | 3-8 | Texas Stadium |
| 13 | November 30, 2008 | 10 a.m. | at Buffalo Bills | W 10-3 | 4-8 | Ralph Wilson Stadium |
| 14 | December 7, 2008 | 1:05 p.m. | New York Jets | W 24-14 | 5-8 | Candlestick Park |