2005 New England Patriots season Regular season Regular season

| Week | Kickoff | Date_ | Opponent | Result_ | Record | Game_Site | NFL_com_Recap |
|---|---|---|---|---|---|---|---|
| 1 | 9:00PM EDT | September 8, 2005 | Oakland Raiders | W 30–20 | 1–0 | Gillette Stadium | Recap |
| 2 | 1:00PM EDT | September 18, 2005 | Carolina Panthers | L 17–27 | 1–1 | Bank of America Stadium | Recap |
| 3 | 4:15PM EDT | September 25, 2005 | Pittsburgh Steelers | W 23–20 | 2–1 | Heinz Field | Recap |
| 4 | 1:00PM EDT | October 2, 2005 | San Diego Chargers | L 17–41 | 2–2 | Gillette Stadium | Recap |
| 5 | 1:00PM EDT | October 9, 2005 | Atlanta Falcons | W 31–28 | 3–2 | Georgia Dome | Recap |
| 6 | 4:15PM EDT | October 16, 2005 | Denver Broncos | L 20–28 | 3–3 | Invesco Field at Mile High | Recap |
| 7 | Bye | Bye | Bye | Bye | Bye | Bye | Bye |