2006 Cincinnati Reds season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 24 | @ Nationals | 4 - 2 | Hernández (1-3) | 19264 | 13-7 |
| April 25 | @ Nationals | 6 - 5 | Traber (1-1) | 21642 | 14-7 |
| April 26 | @ Nationals | 5 - 0 | Ortiz (0-3) | 19380 | 15-7 |
| April 28 | Astros | 5 - 4 | Oswalt (4-1) | 32089 | 16-7 |
| April 29 | Astros | 6 - 3 | Pettitte (1-4) | 24873 | 17-7 |
| April 30 | Astros | 3 - 2 | Ramírez (1-1) | 22814 | 17-8 |