John Isner Singles performance timeline Singles performance timeline

| Tournament | _2007 | _2008 | _2009 | _2010 | _2011 | _2012 |
|---|---|---|---|---|---|---|
| ATP World Tour Masters 1000 | ATP World Tour Masters 1000 | ATP World Tour Masters 1000 | ATP World Tour Masters 1000 | ATP World Tour Masters 1000 | ATP World Tour Masters 1000 | ATP World Tour Masters 1000 |
| Indian Wells Masters | A | 2R | 4R | 4R | 3R | F |
| Miami Masters | A | 1R | 2R | 3R | 4R | 3R |
| Monte Carlo Masters | A | A | A | A | A | A |
| Rome Masters | A | A | A | 2R | 1R | 2R |
| Madrid Masters | A | A | A | 3R | 2R | 2R |
| Canada Masters | A | A | 2R | A | 2R | SF |
| Cincinnati Masters | 1R | 2R | 2R | 2R | 1R | A |
| Shanghai Masters | NMS | NMS | 1R | 2R | A | 3R |
| Paris Masters | A | A | 2R | 2R | SF | 2R |
| Win–Loss | 0–1 | 2–3 | 7–6 | 8–7 | 9–7 | 11–7 |
| Career statistics | Career statistics | Career statistics | Career statistics | Career statistics | Career statistics | Career statistics |