2010 Big East Conference football season Week Two Week Two

| Date_ | Time_ | Visiting_team | Home_team | Site | Broadcast | Result_ | Attendance |
|---|---|---|---|---|---|---|---|
| September 10 | 7:00pm | No. 23 West Virginia | Marshall | Joan C. Edwards Stadium • Huntington, WV | ESPN2 | W 24–21 OT | 41382 |
| September 11 | 12:00pm | South Florida | No. 8 Florida | Ben Hill Griffin Stadium • Gainesville, FL | Big East Network | L 14–38 | 90612 |
| September 11 | 12:00pm | Indiana State | Cincinnati | Nippert Stadium • Cincinnati, OH | FSOHIO | W 40–7 | 30807 |
| September 11 | 12:00pm | Texas Southern | Connecticut | Rentschler Field • East Hartford, CT | Big East Network | W 62–3 | 37359 |
| September 11 | 1:00pm | New Hampshire | Pittsburgh | Heinz Field • Pittsburgh, PA | espn3.com | W 38–16 | 50120 |