5th United States Congress Senate Senate

| State_class | Vacator | Reason_for_change | Successor | Date_of_successors_formal_installation |
|---|---|---|---|---|
| New York (1) | John Sloss Hobart ( F ) | Resigned April 16, 1798 | William North ( F ) | Appointed May 5, 1798 |
| Delaware (2) | Joshua Clayton ( F ) | Died August 11, 1798 | William H. Wells ( F ) | Elected January 17, 1799 |
| New York (1) | William North ( F ) | Interim appointment until August 17, 1798 | James Watson ( F ) | Elected August 17, 1798 |
| New Jersey (1) | John Rutherfurd ( F ) | Resigned November 26, 1798 | Franklin Davenport ( F ) | Appointed December 5, 1798 |
| South Carolina (2) | John Hunter ( DR ) | Resigned November 26, 1798 | Charles Pinckney ( DR ) | Elected December 6, 1798 |