1988 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Record | Game_Site | Attendance |
|---|---|---|---|---|---|---|
| 8 | October 23, 1988 | New England Patriots | W 23–20 | 7–1 | Rich Stadium | 76824 |
| 9 | October 30, 1988 | Green Bay Packers | W 28–0 | 8–1 | Rich Stadium | 79176 |
| 10 | November 6, 1988 | at Seattle Seahawks | W 13–3 | 9–1 | Kingdome | 61074 |
| 11 | November 14, 1988 | at Miami Dolphins | W 31–6 | 10–1 | Joe Robbie Stadium | 67091 |
| 12 | November 20, 1988 | New York Jets | W 9–6 (OT) | 11–1 | Rich Stadium | 78389 |
| 13 | November 27, 1988 | at Cincinnati Bengals | L 35–21 | 11–2 | Riverfront Stadium | 58672 |
| 14 | December 4, 1988 | at Tampa Bay Buccaneers | L 10–5 | 11–3 | Tampa Stadium | 49498 |
| 15 | December 11, 1988 | Los Angeles Raiders | W 37–21 | 12–3 | Rich Stadium | 77348 |
| 16 | December 18, 1988 | at Indianapolis Colts | L 17–14 | 12–4 | Hoosier Dome | 59908 |