2008 Pittsburgh Pirates season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 2 | @ Braves | 10–2 | Gorzelanny (0–1) | 17893 | 1–1 |
| April 3 | @ Braves | 4 – 3 (10) | Resop (0–1) | 19240 | 2–1 |
| April 4 | @ Marlins | 5–4 | Osoria (1–1) | 10089 | 2–2 |
| April 5 | @ Marlins | 7–3 | Maholm (0–1) | 15752 | 2–3 |
| April 6 | @ Marlins | 9–2 | VandenHurk (0–1) | 10431 | 3–3 |
| April 7 | Cubs | 10 – 8 (12) | Meek (0–1) | 37491 | 3–4 |
| April 9 | Cubs | 6 – 4 (15) | Dumatrait (0–1) | 9735 | 3–5 |
| April 10 | Cubs | 7–3 | Morris (0–1) | 9798 | 3–6 |
| April 11 | Reds | 1–0 | Burton (0–1) | 13603 | 4–6 |
| April 12 | Reds | 4–3 | Lincoln (0–1) | 18096 | 5–6 |