2010 Big East Conference football season Week One Week One

| Date_ | Time_ | Visiting_team | Home_team | Site | Broadcast | Result_ | Attendance |
|---|---|---|---|---|---|---|---|
| September 2 | 7:30pm | Norfolk State | Rutgers | Rutgers Stadium • Piscataway, NJ | espn3.com | W 31–0 | 46311 |
| September 2 | 7:30pm | No. 15 Pittsburgh | Utah | Rice-Eccles Stadium • Salt Lake City, UT | Versus | L 24–27 OT | 45730 |
| September 4 | 3:30pm | Connecticut | Michigan | Michigan Stadium • Ann Arbor, MI | ABC | L 10–30 | 113090 |
| September 4 | 3:30pm | Kentucky | Louisville | Papa John`s Cardinal Stadium • Louisville, KY | ABC | L 16–23 | 55327 |
| September 4 | 3:30pm | Coastal Carolina | No. 25 West Virginia | Mountaineer Field • Morgantown, WV | Big East Network | W 31–0 | 57867 |
| September 4 | 6:00pm | Syracuse | Akron | InfoCision Stadium • Akron, OH | ESPN3 | W 29–3 | 15969 |
| September 4 | 7:05pm | Stony Brook | South Florida | Raymond James Stadium • Tampa, FL | ESPN3 | W 59–14 | 40201 |