2008 San Francisco Giants season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 1 | @ Rockies | 4–0 | Sánchez (8–10) | 31388 | 59–78 |
| September 2 | @ Rockies | 6–5 (12) | Yabu (3–6) | 23710 | 59–79 |
| September 3 | @ Rockies | 9–2 | Cook (16–9) | 23481 | 60–79 |
| September 5 | Pirates | 7–0 | Correia (3–8) | 31133 | 60–80 |
| September 6 | Pirates | 7–6 | Bautista (4–3) | 38094 | 61–80 |
| September 7 | Pirates | 11–6 | Karstens (2–5) | 34122 | 62–80 |
| September 8 | D-backs | 6–2 | Petit (3–5) | 30252 | 63–80 |
| September 9 | D-backs | 5–4 | Rauch (4–7) | 30518 | 64–80 |
| September 10 | D-backs | 4–3 | Lyon (2–5) | 30992 | 65–80 |
| September 11 | @ Padres | 11–3 | Cain (8–12) | 30497 | 65–81 |
| September 12 | @ Padres | 5–2 | Peavy (9–11) | 24610 | 66–81 |