1981 San Diego Chargers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 11 | November 16, 1981 | at Seattle Seahawks | L 44–23 | 58628 |
| 12 | November 22, 1981 | at Oakland Raiders | W 55–21 | 50199 |
| 13 | November 29, 1981 | Denver Broncos | W 34–17 | 51533 |
| 14 | December 6, 1981 | Buffalo Bills | L 28–27 | 51488 |
| 15 | December 13, 1981 | at Tampa Bay Buccaneers | W 24–23 | 67388 |
| 16 | December 21, 1981 | Oakland Raiders | W 23–10 | 52279 |