1965 Detroit Lions season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 19, 1965 | Los Angeles Rams | W 20-0 | 46941 |
| 2 | September 26, 1965 | at Minnesota Vikings | W 31-29 | 46826 |
| 3 | October 3, 1965 | Washington Redskins | W 14-10 | 52627 |
| 4 | October 10, 1965 | at Baltimore Colts | L 31-7 | 60238 |
| 5 | October 17, 1965 | Green Bay Packers | L 31-21 | 56712 |
| 6 | October 24, 1965 | at Chicago Bears | L 38-10 | 45658 |
| 7 | October 31, 1965 | at Los Angeles Rams | W 31-7 | 35137 |
| 8 | November 7, 1965 | at Green Bay Packers | W 12-7 | 50852 |
| 9 | November 14, 1965 | San Francisco 49ers | L 27-21 | 54534 |
| 10 | November 21, 1965 | Chicago Bears | L 17-10 | 51499 |