1921–22 FA Cup Second Round Proper Second Round Proper

| Tie_no | Home_team | Score | Away_team | Date_ |
|---|---|---|---|---|
| 11 | Northampton Town | 2–2 | Stoke | 28 January 1922 |
| Replay | Stoke | 3–0 | Northampton Town | 1 February 1922 |
| 12 | Brighton & Hove Albion | 0–0 | Huddersfield Town | 28 January 1922 |
| Replay | Huddersfield Town | 2–0 | Brighton & Hove Albion | 1 February 1922 |
| 13 | Bradford City | 1–1 | Notts County | 28 January 1922 |
| Replay | Notts County | 0–0 | Bradford City | 1 February 1922 |
| Replay | Notts County | 1–0 | Bradford City | 6 February 1922 |
| 14 | Crystal Palace | 0–0 | Millwall | 28 January 1922 |
| Replay | Millwall | 2–0 | Crystal Palace | 1 February 1922 |
| 15 | Southend United | 0–1 | Swansea Town | 28 January 1922 |
| 16 | Bradford Park Avenue | 2–3 | Arsenal | 28 January 1922 |