2008 Houston Texans season Regular season Regular season

| Week | Date_ | Opponent | Result_ | Game_site | Record | Match_Report |
|---|---|---|---|---|---|---|
| 7 | October 19, 2008 | Detroit Lions | W 28–21 | Reliant Stadium | 2–4 | Recap |
| 8 | October 26, 2008 | Cincinnati Bengals | W 35–6 | Reliant Stadium | 3–4 | Recap |
| 9 | November 2, 2008 | at Minnesota Vikings | L 28–21 | Hubert H. Humphrey Metrodome | 3–5 | Recap |
| 10 | November 9, 2008 | Baltimore Ravens ** | L 41–13 | Reliant Stadium | 3–6 | Recap |
| 11 | November 16, 2008 | at Indianapolis Colts | L 33–27 | Lucas Oil Stadium | 3–7 | Recap |
| 12 | November 23, 2008 | at Cleveland Browns | W 16–6 | Cleveland Browns Stadium | 4–7 | Recap |
| 13 | December 1, 2008 | Jacksonville Jaguars * | W 30–17 | Reliant Stadium | 5–7 | Recap |
| 14 | December 7, 2008 | at Green Bay Packers | W 24–21 | Lambeau Field | 6–7 | Recap |