2008 San Diego Padres season Game log May

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| May 13 | @ Cubs | 4–3 | Marquis (1–3) | 40028 | 15–25 |
| May 14 | @ Cubs | 8–5 | Peavy (4–3) | 39650 | 15–26 |
| May 15 | @ Cubs | 4–0 | Maddux (3–4) | 40629 | 15–27 |
| May 16 | @ Mariners | 6–4 | Batista (3–5) | 35586 | 16–27 |
| May 17 | @ Mariners | 4–2 | Wolf (2–4) | 32290 | 16–28 |
| May 18 | @ Mariners | 3–2 | Bell (0–3) | 35483 | 16–29 |
| May 19 | Cardinals | 8–2 | Ledezma (0–1) | 22638 | 16–30 |
| May 20 | Cardinals | 3–2 | Piñeiro (2–3) | 27181 | 17–30 |
| May 21 | Cardinals | 11–3 | Young (4–4) | 21011 | 17–31 |
| May 22 | Reds | 8–2 | Harang (2–6) | 22047 | 18–31 |
| May 23 | Reds | 3–2 | Hoffman (0–3) | 26422 | 18–32 |
| May 24 | Reds | 7–2 | Ledezma (0–2) | 27499 | 18–33 |