2010–11 Belgian Pro League During regular season During regular season

| Team | Outgoing_manager | Manner_of_departure | Date_of_vacancy | Replaced_by | Date_of_appointment | Position_in_table |
|---|---|---|---|---|---|---|
| Eupen | Danny Ost | Resigned | 4 September 2010 | Ezio Capuano | 7 September 2010 | 16th |
| Lierse | Aimé Anthuenis | Sacked | 19 September 2010 | Eric Van Meir | 19 September 2010 | 15th |
| Charleroi | Jacky Mathijssen | Sacked | 20 September 2010 (Dutch) | László Csaba | 23 September 2010 | 14th |
| Eupen | Ezio Capuano | Resigned | 24 September 2010 | Albert Cartier | 24 September 2010 | 16th |
| Zulte-Waregem | Bart De Roover | Sacked | 24 October 2010 | Hugo Broos | 27 October 2010 | 12th |
| Germinal Beerschot | Glen De Boeck | Sacked | 29 November 2010 | Jacky Mathijssen | 2 December 2010 | 13th |
| Lierse | Eric Van Meir | Caretaker replaced | 30 December 2010 | Trond Sollied | 1 January 2011 | 15th |