1981 VFL season Round 4 Round 4

| Home_team | Home_team_score | Away_team | Away_team_score | Venue | Crowd | Date_ |
|---|---|---|---|---|---|---|
| Melbourne | 10.16 (76) | St Kilda | 16.32 (128) | MCG | 36488 | 18 April 1981 |
| Fitzroy | 25.19 (169) | South Melbourne | 14.16 (100) | Junction Oval | 15635 | 18 April 1981 |
| Richmond | 17.22 (124) | North Melbourne | 13.17 (95) | VFL Park | 48526 | 18 April 1981 |
| Essendon | 11.13 (79) | Hawthorn | 13.16 (94) | Windy Hill | 29597 | 20 April 1981 |
| Geelong | 9.14 (68) | Collingwood | 11.10 (76) | Kardinia Park | 42395 | 20 April 1981 |
| Carlton | 15.14 (104) | Footscray | 11.10 (76) | VFL Park | 27299 | 20 April 1981 |