2010 US Open (tennis) Single seeds Women's singles

| Seed | Rank_ | Player | Points | Points_defending | Points_won | New_points | Status_ |
|---|---|---|---|---|---|---|---|
| 24 | 26 | Daniela Hantuchová | 2045 | 280 | 160 | 1925 | 3rd round lost to Elena Dementieva [12] |
| 25 | 27 | Alexandra Dulgheru | 2005 | 5 | 160 | 2160 | 3rd round lost to Vera Zvonareva [7] |
| 26 | 28 | Lucie Šafářová | 1975 | 5 | 5 | 1975 | 1st round lost to Tamira Paszek [Q] |
| 27 | 29 | Petra Kvitová | 1869 | 280 | 160 | 1749 | 3rd round lost to Kim Clijsters [2] |
| 28 | 30 | Alisa Kleybanova | 1840 | 5 | 100 | 1935 | 2nd round lost to Sara Errani |
| 29 | 31 | Alona Bondarenko | 1723 | 100 | 160 | 1783 | 3rd round lost to Francesca Schiavone [6] |
| 30 | 32 | Yaroslava Shvedova | 1770 | 160 | 5 | 1615 | 1st round lost to Lourdes Domínguez Lino [Q] |
| 31 | 33 | Kaia Kanepi | 1725 | 5 | 500 | 2220 | Quarterfinals lost to Vera Zvonareva [7] |