List of people in Playboy 2000–09 2006 2006

| Date_ | Centerfold_model | Interview_subject | _20_Questions | Pictorials |
|---|---|---|---|---|
| 1-06 | Athena Lundberg | Mark Cuban | Kate Beckinsale | Lisa Guerrero |
| 2-06 | Cassandra Lynn | Al Franken | Hugh Laurie | Adrianne Curry, Girls of Tuscany |
| 3-06 | Monica Leigh | Kanye West | Franz Ferdinand | Willa Ford |
| 4-06 | Holley Ann Dorrough | Keanu Reeves | Craig Ferguson | Candice Michelle, Cyber Girls in print |
| 5-06 | Alison Waite | Ozzie Guillén | Rebecca Romijn | Girls of the top 10 party schools, Rachel Sterling |
| 6-06 | Stephanie Larimore | Shepard Smith | Jason Lee | PMOY - Kara Monaco, Girls of MySpace |
| 7-06 | Sara Jean Underwood | Jerry Bruckheimer | Dana White | Vida Guerra |
| 8-06 | Nicole Voss | Denis Leary | Luke Wilson | Girls of Orange County , Stacey Dash |