2005–06 U.S. Città di Palermo season Serie A Serie A

| Date_and_time | Opponent | Venue | Result_ | Attendance |
|---|---|---|---|---|
| October 30, 2005 – 20.30 | Udinese | Away | Drew 0-0 | 16561 |
| November 6, 2005 – 20.30 | Sampdoria | Home | Lost 0-2 | 29087 |
| November 20, 2005 – 15.00 | Treviso | Away | Drew 2-2 | 5540 |
| November 27, 2005 – 15.00 | Ascoli | Away | Drew 1-1 | 9790 |
| December 4, 2005 – 15.00 | Cagliari | Home | Drew 2-2 | 26209 |
| December 11, 2005 – 15.00 | AS Roma | Away | Won 2-1 | 35316 |
| December 18, 2005 – 15.00 | Livorno | Home | Lost 0-2 | 26151 |
| December 21, 2005 – 20.30 | Fiorentina | Away | Lost 0-1 | 29487 |
| January 7, 2006 – 20.30 | Juventus | Home | Lost 1-2 | 33149 |
| January 14, 2006 – 20.30 | Messina | Away | Drew 0-0 | 20233 |