1980–81 FA Cup First round proper First round proper

| Tie_no | Home_team | Score | Away_team | Date_ |
|---|---|---|---|---|
| 20 | Plymouth Argyle | 2–0 | Newport County | 22 November 1980 |
| 21 | Hull City | 2–1 | Halifax Town | 22 November 1980 |
| 22 | Wimbledon | 7–2 | Windsor & Eton | 22 November 1980 |
| 23 | Southend United | 0–1 | Hereford United | 22 November 1980 |
| 24 | Exeter City | 5–0 | Leatherhead | 22 November 1980 |
| 25 | Scunthorpe United | 3–1 | Hartlepool United | 22 November 1980 |
| 26 | Blyth Spartans | 2–1 | Burton Albion | 22 November 1980 |
| 27 | Mansfield Town | 3–1 | Rochdale | 22 November 1980 |
| 28 | Port Vale | 4–2 | Bradford City | 22 November 1980 |
| 29 | Torquay United | 2–0 | Barton Rovers | 22 November 1980 |
| 30 | Workington | 0–0 | Carlisle United | 22 November 1980 |
| Replay | Carlisle United | 4–1 | Workington | 1 December 1980 |