List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation

| Year_ | City | State_province_dept_etc_ | Country | Notes_ |
|---|---|---|---|---|
| 1520 | Hato Mayor del Rey | Hato Mayor | Dominican Republic |  |
| 1521 | Cumaná | Sucre | Venezuela | Oldest continuously inhabited European established settlement in Venezuela. |
| 1521 | San Juan | Puerto Rico | United States | Oldest continuously inhabited European established settlement in Puerto Rico, and in the United States. Oldest continuously inhabited state or territorial capital in the United States. |
| 1524 | Granada | Granada | Nicaragua | Oldest continuously inhabited European established settlement in Nicaragua. |
| 1524 | Tecpán Guatemala | Chimaltenango | Guatemala | First capital of Guatemala and oldest continuously inhabited European established settlement in Guatemala. |
| 1524 | Trujillo | Colón | Honduras | Oldest continuously inhabited European established settlement in Honduras. |
| 1525 | Santa Marta | Magdalena | Colombia | Oldest continuously inhabited European established settlement in Colombia. |