List of highway route numbers in Oregon Mainline routes Mainline routes

| Number_ | South_west_end | North_east_end | Formed | Eliminated_ |
|---|---|---|---|---|
| Oregon Route 50 | OR 10 in Portland | US 97 in Madras | 1932 | 1952 |
| Oregon Route 51 | OR 99W/OR 194 in Monmouth | OR 22 west of Salem | 1932 |  |
| Oregon Route 52 | OR 201 north of Ontario | SH-52 in Payette, ID | 1940s |  |
| Oregon Route 52 | US 26 near Bear Springs | US 197 near Maupin | 1940s | 1950s |
| Oregon Route 53 | US 101 near Wheeler | US 26 at Necanicum | 1939 |  |
| Oregon Route 54 | OR 99E in Albany | US 28 in Vale | 1932 | 1940 |
| Oregon Route 58 | I-5/OR 99 at Goshen | US 97 north of Chemult | 1932 |  |
| Oregon Route 62 | OR 99/OR 238 in Medford | US 97 south of Chiloquin | 1932 |  |