49ers–Rams rivalry 2010s (49ers 3-2-1) 2010s (49ers 3-2-1)

| Year_ | Date_ | Home_Team | Result_ | Visiting_Team | Venue |
|---|---|---|---|---|---|
| 2010 | November 14 | San Francisco 49ers | 23-20 OT | St. Louis Rams | Candlestick Park |
| 2010 | December 26 | St. Louis Rams | 25-17 | San Francisco 49ers | Edward Jones Dome |
| 2011 | December 4 | San Francisco 49ers | 26-0 | St. Louis Rams | Candlestick Park |
| 2011 | January 1 | St Louis Rams | 27-34 | San Francisco 49ers | Edward Jones Dome |
| 2012 | November 11 | San Francisco 49ers | 24-24 OT | St. Louis Rams | Candlestick Park |
| 2012 | December 2 | St Louis Rams | 16-13 OT | San Francisco 49ers | Edward Jones Dome |