USA Today All-USA high school football team 2010 team Second Team Offense

| Player | Position_ | School | Hometown | College |
|---|---|---|---|---|
| Cody Kessler | Quarterback | Centennial High School | Bakersfield, California | Southern California |
| Mike Bellamy | Running back | Charlotte High School | Punta Gorda, Florida | Clemson |
| Aaron Green | Running back | Madison High School | San Antonio, Texas | Nebraska |
| Nick O`Leary | Tight end | Dwyer High School | West Palm Beach, Florida | Florida State |
| Trey Metoyer | Wide receiver | Whitehouse High School | Whitehouse, Texas | Oklahoma |
| Charone Peake | Wide receiver | Dorman High School | Roebuck, South Carolina | Clemson |
| Matt Freeman | Offensive line | Cooper High School | Abilene, Texas | Texas State |
| Ryne Reeves | Offensive line | Crete High School | Crete, Nebraska | Nebraska |
| Kiaro Holts | Offensive line | Warren Central High School | Indianapolis, Indiana | North Carolina |