Swiss International Air Lines destinations Destinations Destinations

| City | Country | IATA | ICAO | Airport |
|---|---|---|---|---|
| Johannesburg | South Africa | JNB | FAJS | OR Tambo Airport |
| Karachi | Pakistan | KHI | OPKC | Jinnah Airport |
| Kiev | Ukraine | KBP | UKBB | Boryspil International Airport |
| Lagos | Nigeria | LOS | DNMM | Murtala Muhammed Airport |
| Libreville | Gabon | LBV | FOOL | Leon M`ba Airport |
| Lisbon | Portugal | LIS | LPPT | Portela Airport |
| London | United Kingdom | LCY | EGLC | City Airport |
| London [begins 2013-12-14] | United Kingdom | LGW | EGKK | Gatwick Airport |
| London | United Kingdom | LHR | EGLL | Heathrow Airport |
| Los Angeles | United States | LAX | KLAX | Los Angeles International Airport |
| Lugano | Switzerland | LUG | LSZA | Agno Airport |
| Luxembourg City | Luxembourg | LUX | ELLX | Findel Airport |
| Lyon | France | LYS | LFLL | Saint-Exupéry Airport |
| Madrid | Spain | MAD | LEMD | Madrid-Barajas Airport |
| Malabo | Equatorial Guinea | SSG | FGSL | Saint Isabel Airport |