1981 San Francisco 49ers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 6, 1981 | at Detroit Lions | L 17-24 | 63710 |
| 2 | September 13, 1981 | Chicago Bears | W 28-17 | 49520 |
| 3 | September 20, 1981 | at Atlanta Falcons | L 17-34 | 56653 |
| 4 | September 27, 1981 | New Orleans Saints | W 21-14 | 44433 |
| 5 | October 4, 1981 | at Washington Redskins | W 30-17 | 51843 |
| 6 | October 11, 1981 | Dallas Cowboys | W 45-14 | 57574 |
| 7 | October 18, 1981 | at Green Bay Packers | W 13-3 | 50171 |
| 8 | October 25, 1981 | Los Angeles Rams | W 20-17 | 59190 |
| 9 | November 1, 1981 | at Pittsburgh Steelers | W 17-14 | 52878 |
| 10 | November 8, 1981 | Atlanta Falcons | W 17-14 | 59127 |