2010–11 UEFA Champions League Round of 16 Round of 16

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Roma | 2–6 | Shakhtar Donetsk | 2–3 | 0–3 |
| Milan | 0–1 | Tottenham Hotspur | 0–1 | 0–0 |
| Valencia | 2–4 | Schalke 04 | 1–1 | 1–3 |
| Internazionale | ( a )3–3 | Bayern Munich | 0–1 | 3–2 |
| Lyon | 1–4 | Real Madrid | 1–1 | 0–3 |
| Arsenal | 3–4 | Barcelona | 2–1 | 1–3 |
| Marseille | 1–2 | Manchester United | 0–0 | 1–2 |
| Copenhagen | 0–2 | Chelsea | 0–2 | 0–0 |