1980 Cleveland Browns season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 7, 1980 | at New England Patriots | L 34–17 | 49222 |
| 2 | September 15, 1980 | Houston Oilers | L 16–7 | 80243 |
| 3 | September 21, 1980 | Kansas City Chiefs | W 20–13 | 63614 |
| 4 | September 28, 1980 | at Tampa Bay Buccaneers | W 34–27 | 65540 |
| 5 | October 5, 1980 | Denver Broncos | L 19–16 | 81065 |
| 6 | October 12, 1980 | at Seattle Seahawks | W 27–3 | 61366 |
| 7 | October 19, 1980 | Green Bay Packers | W 26–21 | 75548 |
| 8 | October 26, 1980 | Pittsburgh Steelers | W 27–26 | 79095 |
| 9 | November 3, 1980 | Chicago Bears | W 27–21 | 84225 |
| 10 | November 9, 1980 | at Baltimore Colts | W 28–27 | 45369 |