1981 VFL season Round 2 Round 2

| Home_team | Home_team_score | Away_team | Away_team_score | Venue | Crowd | Date_ |
|---|---|---|---|---|---|---|
| Essendon | 16.15 (111) | North Melbourne | 15.9 (99) | Windy Hill | 26443 | 4 April 1981 |
| Collingwood | 26.22 (178) | Footscray | 13.6 (84) | Victoria Park | 26512 | 4 April 1981 |
| South Melbourne | 16.14 (110) | Richmond | 22.13 (145) | Lake Oval | 17850 | 4 April 1981 |
| St Kilda | 14.23 (107) | Geelong | 16.13 (109) | Moorabbin Oval | 24496 | 4 April 1981 |
| Hawthorn | 16.11 (107) | Carlton | 17.21 (123) | Princes Park | 31660 | 4 April 1981 |
| Fitzroy | 23.17 (155) | Melbourne | 16.14 (110) | VFL Park | 20107 | 4 April 1981 |