2001 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Record | Game_Site | Attendance |
|---|---|---|---|---|---|---|
| 1 | September 9, 2001 | New Orleans Saints | L 6–24 | 0–1 | Ralph Wilson Stadium | 71447 |
| 2 | September 23, 2001 | at Indianapolis Colts | L 26–42 | 0–2 | RCA Dome | 56135 |
| 3 | September 30, 2001 | Pittsburgh Steelers | L 3–20 | 0–3 | Ralph Wilson Stadium | 72874 |
| 4 | October 7, 2001 | New York Jets | L 36–42 | 0–4 | Ralph Wilson Stadium | 72654 |
| 5 | Bye | Bye | Bye | Bye | Bye | Bye |
| 6 | October 18, 2001 | at Jacksonville Jaguars | W 13–10 | 1–4 | Alltel Stadium | 58893 |
| 7 | October 28, 2001 | at San Diego Chargers | L 24–27 | 1–5 | Qualcomm Stadium | 63698 |