1980 New England Patriots season Schedule Schedule

| Week | Opponent | Result_ | Stadium | Record | Attendance |
|---|---|---|---|---|---|
| 11 | Los Angeles Rams | L 14–17 | Schaefer Stadium | 7–4 | 60609 |
| 12 | Baltimore Colts | W 47–21 | Schaefer Stadium | 8–4 | 60994 |
| 13 | at San Francisco 49ers | L 17–21 | Candlestick Park | 8–5 | 45254 |
| 14 | at Miami Dolphins | L 13–16 | Miami Orange Bowl | 8–6 | 63292 |
| 15 | Buffalo Bills | W 24–2 | Schaefer Stadium | 9–6 | 58324 |