1988 in film Highest-grossing films (U.S.) Highest-grossing films (U.S.)

| Rank_ | Title | Studio | Director | Gross |
|---|---|---|---|---|
| 1. | Rain Man | United Artists | Barry Levinson | $172,825,435 |
| 2. | Who Framed Roger Rabbit | Touchstone / Amblin | Robert Zemeckis | $156,452,370 |
| 3. | Coming to America | Paramount | John Landis | $128,152,301 |
| 4. | Big | 20th Century Fox / Gracie | Penny Marshall | $114,968,774 |
| 5. | Twins | Universal | Ivan Reitman | $111,938,388 |
| 6. | Crocodile Dundee II | Paramount | John Cornell | $109,306,210 |
| 7. | Die Hard | 20th Century Fox / Silver | John McTiernan | $83,008,852 |
| 8. | The Naked Gun: From the Files of Police Squad! | Paramount | David Zucker | $78,756,177 |
| 9. | Cocktail | Touchstone | Roger Donaldson | $78,222,753 |
| 10. | Beetlejuice | Geffen / Warner Bros. | Tim Burton | $73,707,461 |
| 11. | Working Girl | 20th Century Fox | Mike Nichols | $63,779,477 |