2009–10 UEFA Europa League Play-off round Play-off round

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| PAOK | 1–1 ( a ) | Heerenveen | 1–1 | 0–0 |
| Dinamo Zagreb | 4–2 | Hearts | 4–0 | 0–2 |
| Werder Bremen | 8–3 | Aktobe | 6–3 | 2–0 |
| Everton | 5–1 | Sigma Olomouc | 4–0 | 1–1 |
| BATE Borisov | 4–1 | Litex Lovech | 0–1 | 4–0 ( aet ) |
| NAC Breda | 2–9 | Villarreal | 1–3 | 1–6 |
| Lech Poznań | 1–1 (3–4 p ) | Club Brugge | 1–0 | 0–1 ( aet ) |
| Fulham | 3–2 | Amkar Perm | 3–1 | 0–1 |
| Galatasaray | 6–1 | Levadia | 5–0 | 1–1 |
| Teplice | 2–3 | Hapoel Tel Aviv | 1–2 | 1–1 |
| Metalurh Donetsk | 4–5 | Austria Wien | 2–2 | 2–3 ( aet ) |
| Twente | 3–1 | Karabakh | 3–1 | 0–0 |
| Košice | 4–10 † | Roma | 3–3 | 1–7 |