2008 Colorado Rockies season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 14 | Dodgers | 1–0 (10) | Kuo (5–3) | 28910 | 68–82 |
| September 15 | Padres | 11–5 | Reynolds (2–7) | 25296 | 68–83 |
| September 16 | Padres | 10–3 | Estes (2–3) | 25507 | 69–83 |
| September 17 | Padres | 1–0 | Geer (2–1) | 25155 | 70–83 |
| September 19 | Diamondbacks | 3–2 | Scherzer (0–3) | 43137 | 71–83 |
| September 20 | Diamondbacks | 5–3 | Fuentes (1–5) | 38283 | 71–84 |
| September 21 | Diamondbacks | 13–4 | Reynolds (2–8) | 32915 | 71–85 |
| September 23 | @ Giants | 9–4 | Lincecum (17–5) | 33922 | 72–85 |
| September 24 | @ Giants | 15–6 | Sánchez (9–12) | 31942 | 73–85 |
| September 25 | @ Giants | 3–1 | Zito (10–17) | 31857 | 74–85 |
| September 26 | @ Diamondbacks | 6–4 | Grilli (3–2) | 34590 | 74–86 |
| September 27 | @ Diamondbacks | 6–4 | Corpas (3–4) | 33234 | 74–87 |
| September 28 | @ Diamondbacks | 2–1 | Vizcaíno (1–2) | 35908 | 74–88 |