2010 US Open (tennis) Singles seeds Men's singles

| Seed | Rank_ | Player | Points | Points_defending | Points_won | New_points | Status_ |
|---|---|---|---|---|---|---|---|
| 17 | 19 | Gaël Monfils | 2070 | 180 | 360 | 2250 | Quarterfinals lost to Novak Djokovic [3] |
| 18 | 20 | John Isner | 1805 | 180 | 90 | 1715 | 3rd round lost to Mikhail Youzhny [12] |
| 19 | 21 | Mardy Fish | 1751 | 0 | 180 | 1931 | 4th round lost to Novak Djokovic [3] |
| 20 | 22 | Sam Querrey | 1705 | 90 | 180 | 1795 | 4th round lost to Stanislas Wawrinka [25] |
| 21 | 23 | Albert Montañés | 1600 | 10 | 180 | 1770 | 4th round lost to Robin Söderling [5] |
| 22 | 24 | Juan Carlos Ferrero | 1560 | 180 | 90 | 1470 | 3rd round lost to Jürgen Melzer [13] |
| 23 | 25 | Feliciano López | 1515 | 10 | 180 | 1685 | 4th round lost to Rafael Nadal [1] |