2010 East–West Shrine Game 2010 NFL Draft 2010 NFL Draft

| Round_ | Pick_ | NFL_Team | Player | Position_ | College |
|---|---|---|---|---|---|
| 2 | 33 | St. Louis Rams | Rodger Saffold | Offensive tackle | Indiana |
| 2 | 38 | Cleveland Browns | T. J. Ward | Safety | Oregon |
| 2 | 41 | Buffalo Bills | Torrell Troup | Defensive tackle | UCF |
| 2 | 56 | Green Bay Packers | Mike Neal | Defensive tackle | Purdue |
| 3 | 81 | Houston Texans | Earl Mitchell | Defensive tackle | Arizona |
| 3 | 82 | Pittsburgh Steelers | Emmanuel Sanders | Wide receiver | SMU |
| 3 | 86 | Philadelphia Eagles (from Green Bay) | Daniel Te`o-Nesheim | Defensive end | Washington |
| 4 | 104 | Tennessee Titans (from Seattle) | Alterraun Verner | Cornerback | UCLA |
| 4 | 110 | San Diego Chargers (from Miami) | Darrell Stuckey | Safety | Kansas |
| 4 | 114 | Baltimore Ravens (from Denver) | Dennis Pitta | Tight end | BYU |