2000 Cleveland Indians season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 20 | @ Red Sox | 5 - 4 | Cormier (2-3) | 32751 | 82-67 |
| September 21 | @ Red Sox | 9 - 8 | Speier (4-2) | 31404 | 82-68 |
| September 21 | @ Red Sox | 8 - 5 | Wakefield (6-10) | 32743 | 83-68 |
| September 22 | @ Royals | 3 - 2 | Karsay (5-9) | 15036 | 83-69 |
| September 23 | @ Royals | 11 - 1 | Reichert (8-9) | 20253 | 84-69 |
| September 24 | @ Royals | 9 - 0 | Nagy (2-7) | 12606 | 84-70 |
| September 25 | White Sox | 9 - 2 | Garland (4-8) | 42500 | 85-70 |
| September 25 | Twins | 4 - 3 | Shuey (4-2) | 42853 | 85-71 |
| September 26 | Twins | 4 - 2 | Romero (2-7) | 42773 | 86-71 |
| September 27 | Twins | 8 - 2 | Radke (12-16) | 42864 | 87-71 |