Mid-Southern Conference of Indiana Membership Membership

| School | Location_ | Mascot | Enrollment | IHSAA_Class | _County | Year_Joined |
|---|---|---|---|---|---|---|
| Austin * | Austin | Eagles | 437 | AA | 72 Scott | 1958 |
| Brownstown Central | Brownstown | Braves | 611 | AAA | 36 Jackson | 1965 |
| Charlestown | Charlestown | Pirates | 702 | AAA | 10 Clark | 1958 |
| Clarksville | Clarksville | Generals | 530 | AA | 10 Clark | 1958 |
| Corydon Central | Corydon | Panthers | 819 | AAA | 31 Harrison | 1958 |
| Eastern (Pekin) | New Pekin | Musketeers | 552 | AA | 88 Washington | 2003 |
| North Harrison | Ramsey | Cougars | 702 | AAA | 31 Harrison | 1978 |
| Salem | Salem | Lions | 656 | AAA | 88 Washington | 1958 |
| Scottsburg | Scottsburg | Warriors | 865 | AAA | 72 Scott | 1958 |
| Silver Creek | Sellersburg | Dragons | 644 | AAA | 10 Clark | 1958 |