2008 San Diego Padres season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| March 31 | Astros | 4–0 | Oswalt (0–1) | 44965 | 1–0 |
| April 1 | Astros | 2–1 | Backe (0–1) | 20825 | 2–0 |
| April 2 | Astros | 9–6 | Hoffman (0–1) | 18714 | 2–1 |
| April 3 | Astros | 3–2 | Villarreal (0–1) | 24432 | 3–1 |
| April 4 | Dodgers | 7–1 | Thatcher (0–1) | 42474 | 3–2 |
| April 5 | Dodgers | 4–1 | Penny (1–1) | 38819 | 4–2 |
| April 6 | Dodgers | 3–2 | Hoffman (0–2) | 44165 | 4–3 |
| April 7 | @ Giants | 8–4 | Cain (0–1) | 42861 | 5–3 |
| April 8 | @ Giants | 3 – 2 (11) | Meredith (0–1) | 35795 | 5–4 |
| April 9 | @ Giants | 1–0 | Bell (0–1) | 30310 | 5–5 |
| April 11 | @ Dodgers | 7–5 | Penny (1–2) | 54052 | 6–5 |