List of Houston Astros Opening Day starting pitchers Pitchers Pitchers

| Season | Pitcher | Decision | Final_score | Opponent | Location_ |
|---|---|---|---|---|---|
| 1983 | Joe Niekro (2) | ND (L) | 7–16 | Los Angeles Dodgers | Astrodome |
| 1984 | Joe Niekro (3) | L | 2–4 | Montreal Expos | Astrodome |
| 1985 | Nolan Ryan (2) | W | 2–1 | Los Angeles Dodgers | Astrodome |
| 1986* | Nolan Ryan (3) | L | 3–8 | San Francisco Giants | Astrodome |
| 1987 | Mike Scott | W | 4–3 | Los Angeles Dodgers | Astrodome |
| 1988 | Mike Scott (2) | W | 6–3 | San Diego Padres | Astrodome |
| 1989 | Mike Scott (3) | W | 10–3 | Atlanta Braves | Astrodome |
| 1990 | Mike Scott (4) | ND (L) | 4–8 | Cincinnati Reds | Astrodome |
| 1991 | Mike Scott (5) | L | 2–6 | Cincinnati Reds | Riverfront Stadium |
| 1992 | Pete Harnisch | L | 0–2 | Atlanta Braves | Astrodome |
| 1993 | Doug Drabek | L | 1–3 | Philadelphia Phillies | Astrodome |