2010 Southeastern Conference football season Week Four Week Four

| Date_ | Time_ | Visiting_team | Home_team | Site | Broadcast | Result_ | Attendance |
|---|---|---|---|---|---|---|---|
| September 25 | 12:21pm | UAB | Tennessee | Neyland Stadium • Knoxville, TN | SEC Network | W 32–29 2OT | 95183 |
| September 25 | 3:30pm | #1 Alabama | #10 Arkansas | Razorback Stadium • Fayetteville, AR | CBS | ALA 24–20 | 76808 |
| September 25 | 7:00pm | Kentucky | #9 Florida | Ben Hill Griffin Stadium • Gainesville, FL | ESPNU | FLA 48–14 | 90547 |
| September 25 | 7:00pm | Georgia | Mississippi State | Davis Wade Stadium • Starkville, MS | FSN | MSST 24–12 | 56721 |
| September 25 | 7:30pm | Fresno State | Ole Miss | Vaught-Hemingway Stadium • Oxford, MS | CSS | W 55–38 | 55267 |
| September 25 | 7:45pm | #12 South Carolina | #17 Auburn | Jordan-Hare Stadium • Auburn, AL | ESPN | AUB 35–27 | 87237 |