List of Houston Astros Opening Day starting pitchers Pitchers Pitchers

| Season | Pitcher | Decision | Final_score | Opponent | Location_ |
|---|---|---|---|---|---|
| 1972 | Don Wilson (2) | L | 0–5 | San Francisco Giants | Astrodome |
| 1973 | Dave Roberts | ND (W) | 2–1 | Atlanta Braves | Atlanta-Fulton County Stadium |
| 1974 | Dave Roberts (2) | L | 1–5 | San Francisco Giants | Candlestick Park |
| 1975 | Larry Dierker (4) | W | 6–2 | Atlanta Braves | Astrodome |
| 1976 | J.R. Richard | L | 5–11 | Cincinnati Reds | Riverfront Stadium |
| 1977 | J.R. Richard (2) | ND (W) | 3–2 | Atlanta Braves | Astrodome |
| 1978 | J.R. Richard (3) | L | 9–11 | Cincinnati Reds | Riverfront Stadium |
| 1979 | J.R. Richard (4) | W | 2–1 | Atlanta Braves | Astrodome |
| 1980* | J.R. Richard (5) | W | 3–2 | Los Angeles Dodgers | Astrodome |
| 1981* | Joe Niekro | L | 0–2 | Los Angeles Dodgers | Dodger Stadium |
| 1982 | Nolan Ryan | L | 3–14 | St. Louis Cardinals | Astrodome |