2000–01 Sheffield Wednesday F.C. season Football League First Division Football League First Division

| Date_ | Opponent | Venue | Result_ | Attendance |
|---|---|---|---|---|
| 22 October 2000 | Birmingham City | H | 1-0 | 14695 |
| 25 October 2000 | Queens Park Rangers | A | 2-1 | 10353 |
| 28 October 2000 | Fulham | H | 3-3 | 17559 |
| 4 November 2000 | Crystal Palace | A | 1-4 | 15333 |
| 7 November 2000 | Watford | A | 3-1 | 11166 |
| 11 November 2000 | Norwich City | H | 3-2 | 16956 |
| 18 November 2000 | Barnsley | A | 0-1 | 19989 |
| 25 November 2000 | Crewe Alexandra | A | 0-1 | 7103 |
| 2 December 2000 | Queens Park Rangers | H | 5-2 | 21782 |
| 9 December 2000 | Stockport County | H | 2-4 | 16337 |
| 16 December 2000 | Sheffield United | A | 1-1 | 25156 |
| 23 December 2000 | Wolverhampton Wanderers | H | 0-1 | 17787 |
| 26 December 2000 | Bolton Wanderers | A | 0-2 | 21316 |