Club Santos Laguna Most Appearances Most Appearances

| Player | Period | League | Concacaf | Libertadores | Merconorte | InterLiga | Superliga | Matches |
|---|---|---|---|---|---|---|---|---|
| Rodrigo Ruiz | 2000 – 2006 / 2010 – 2011 | 294 | 12 | 8 | 8 | 7 | 0 | 329 |
| Jared Borgetti | 1996–2004 | 295 | 0 | 8 | 4 | 4 | 0 | 311 |
| Oswaldo Sánchez | 2007 – | 252 | 25 | 0 | 0 | 4 | 7 | 289 |
| Juan Pablo Rodríguez | 2007 – | 251 | 25 | 0 | 0 | 3 | 6 | 287 |
| Iván Estrada | 2007–2013 | 244 | 31 | 0 | 0 | 2 | 7 | 284 |
| Carlos Cariño | 2000–2006 | 251 | 2 | 8 | 6 | 7 | 0 | 274 |
| Héctor Altamirano | 1998–2005 | 237 | 4 | 8 | 8 | 7 | 0 | 264 |
| Rafael Figueroa | 2005– | 223 | 22 | 0 | 0 | 2 | 7 | 260 |