2005–06 Eccellenza season Second round Second round

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| La Nuova Piovese (Veneto A) | 4–3 | Corsico (Lombardy A) | 2–3 | 2–0 |
| Biella L.M. (Piedmont A) | 0–3 | Sarzanese (Liguria) | 0–0 | 0–3 |
| Valle del Giovenco (Abruzzo) | 4–2 | Voluntas Osio di Sotto (Lombardy B) | 1–2 | 3–0 |
| Forte dei Marmi (Tuscany A) | 4–3 | Castelnuovese (Tuscany B) | 2–2 | 2–1 |
| Budoni (Sardinia) | 2–2( a ) | Civitavecchiese (Latium A) | 2–2 | 0–0 |
| Fasano (Apulia) | 2–4 | Acicatena (Sicily A) | 2–1 | 0–3 |
| Gragnano (Campania B) | 4–4 7–10( p ) | Castrovillari (Calabria) | 3–1 | 1–3 |