1980–81 FA Cup Second Round Proper Second Round Proper

| Tie_no | Home_team | Score | Away_team | Date_ |
|---|---|---|---|---|
| 17 | Charlton Athletic | 2–1 | Bournemouth | 13 December 1980 |
| 18 | Rotherham United | 0–1 | Barnsley | 13 December 1980 |
| 19 | Colchester United | 1–1 | Yeovil Town | 13 December 1980 |
| Replay | Yeovil Town | 0–2 | Colchester United | 17 December 1980 |
| 20 | Mossley F.C. | 1–3 | Mansfield Town | 13 December 1980 |