2001 Cleveland Indians season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 2 | White Sox | 7 - 4 | Colón (0-1) | 42606 | 0-1 |
| April 4 | White Sox | 8 - 4 | Eldred (0-1) | 32763 | 1-1 |
| April 6 | Orioles | 4 - 3 | Mercedes (0-1) | 32738 | 2-1 |
| April 7 | Orioles | 4 - 2 (11) | Reed (0-1) | 40704 | 2-2 |
| April 8 | Orioles | 4 - 3 | Maduro (0-1) | 40754 | 3-2 |
| April 9 | @ White Sox | 9 - 2 | Finley (1-1) | 21242 | 3-3 |
| April 10 | @ White Sox | 8 - 7 | Shuey (0-1) | 12465 | 3-4 |
| April 11 | @ White Sox | 7 - 6 | Burba (0-1) | 12693 | 3-5 |
| April 12 | @ Tigers | 5 - 3 | Holt (1-1) | 15639 | 4-5 |