Mike Bryan Doubles: 25 (15–10) Doubles: 25 (15–10)

| Outcome | Year_ | Championship | Surface | Partner | Opponents | Score |
|---|---|---|---|---|---|---|
| Runner-up | 2012 | French Open | Clay | Bob Bryan | Max Mirnyi Daniel Nestor | 6–4, 6–4 |
| Winner | 2012 | US Open | Hard | Bob Bryan | Leander Paes Radek Štěpánek | 6–3, 6–4 |
| Winner | 2013 | Australian Open | Hard | Bob Bryan | Robin Haase Igor Sijsling | 6–3, 6–4 |
| Winner | 2013 | French Open | Clay | Bob Bryan | Michaël Llodra Nicolas Mahut | 6–4, 4–6, 7–6 (7–4) |