2006 Cincinnati Reds season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 12 | Padres | 5 - 4 | Brocail (2-2) | 15820 | 72-72 |
| September 13 | Padres | 10 - 0 | Lohse (2-3) | 21602 | 72-73 |
| September 14 | Padres | 4 - 2 | Harang (13-11) | 16957 | 72-74 |
| September 15 | @ Cubs | 4 - 0 | Mármol (5-7) | 37188 | 73-74 |
| September 16 | @ Cubs | 4 - 0 | Michalak (1-3) | 40526 | 73-75 |
| September 17 | @ Cubs | 11 - 3 | Milton (8-8) | 39164 | 73-76 |
| September 18 | @ Astros | 5 - 3 | Lohse (2-4) | 28711 | 73-77 |
| September 19 | @ Astros | 5 - 4 | Albers (0-2) | 36930 | 74-77 |
| September 20 | @ Astros | 7 - 2 | Arroyo (14-10) | 31928 | 74-78 |
| September 22 | Cubs | 4 - 2 | Hill (6-7) | 21332 | 75-78 |