2006 Cincinnati Reds season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 3 | Cubs | 16 - 7 | Harang (0-1) | 42591 | 0-1 |
| April 5 | Cubs | 8 - 6 | Rusch (0-1) | 27287 | 1-1 |
| April 6 | Pirates | 6 - 5 | González (0-1) | 13887 | 2-1 |
| April 7 | Pirates | 7 - 6 | Maholm (0-1) | 16573 | 3-1 |
| April 8 | Pirates | 11 - 9 | Pérez (0-1) | 20244 | 4-1 |
| April 9 | Pirates | 5 - 3 | Williams (0-1) | 22090 | 4-2 |
| April 11 | @ Cubs | 9 - 2 | Rusch (0-2) | 36708 | 5-2 |
| April 12 | @ Cubs | 4 - 1 | Claussen (0-1) | 37252 | 5-3 |
| April 13 | @ Cubs | 8 - 3 | Zambrano (0-1) | 40881 | 6-3 |