2010 Campeonato Brasileiro Série A Managerial changes Managerial changes

| Team | Outgoing_manager | Manner_of_departure | Date_of_vacancy | Position_in_table | Replaced_by | Date_of_appointment |
|---|---|---|---|---|---|---|
| Vitória | Toninho Cecílio | Sacked | September 8 | 15th | Ricardo Silva | September 9 |
| Grêmio Prudente | Antônio Carlos Zago | Sacked | September 10 | 19th | Marcelo Rospide | September 10 |
| Avaí | Antônio Lopes | Sacked | September 20 | 16th | Vagner Benazzi | October 10 |
| Santos | Dorival Júnior | Sacked | September 21 | 6th | Marcelo Martelotte (caretaker) | September 21 |
| Atlético Mineiro | Vanderlei Luxemburgo | Sacked | September 23 | 18th | Dorival Júnior | September 25 |
| Grêmio Prudente | Marcelo Rospide | Resigned | September 27 | 20th | Fábio Giuntini | October 5 |
| Atlético Paranaense | Paulo César Carpegiani | Left to sign with São Paulo | October 3 | 5th | Sérgio Soares | October 4 |
| São Paulo | Sérgio Baresi | Replaced | October 3 | 11th | Paulo César Carpegiani | October 3 |