1988 Houston Oilers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 4, 1988 | at Indianapolis Colts | W 17–14 | 57251 |
| 2 | September 11, 1988 | Los Angeles Raiders | W 38–35 | 46050 |
| 3 | September 18, 1988 | at New York Jets | L 45–3 | 64683 |
| 4 | September 25, 1988 | New England Patriots | W 31–6 | 38646 |
| 5 | October 2, 1988 | at Philadelphia Eagles | L 32–23 | 64692 |
| 6 | October 9, 1988 | Kansas City Chiefs | W 7–6 | 39134 |
| 7 | October 16, 1988 | at Pittsburgh Steelers | W 34–14 | 52229 |
| 8 | October 23, 1988 | at Cincinnati Bengals | L 44–21 | 54659 |
| 9 | October 30, 1988 | Washington Redskins | W 41–17 | 48781 |
| 10 | November 7, 1988 | Cleveland Browns | W 24–17 | 51467 |