2008 Arizona Diamondbacks season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 14 | Reds | 2-1 (10) | Rauch (4-8) | 27297 | 72-76 |
| September 15 | Giants | 3-1 | Hennessey (1-2) | 25969 | 73-76 |
| September 16 | Giants | 2-0 | Cain (8-13) | 33195 | 74-76 |
| September 17 | Giants | 7-6 | Sánchez (9-11) | 22616 | 75-76 |
| September 18 | Giants | 3-2 | Lincecum (17-4) | 34323 | 76-76 |
| September 19 | @ Rockies | 3-2 | Scherzer (0-3) | 43137 | 76-77 |
| September 20 | @ Rockies | 5-3 | Fuentes (1-5) | 38283 | 77-77 |
| September 21 | @ Rockies | 13-4 | Reynolds (2-8) | 32915 | 78-77 |
| September 22 | @ Cardinals | 4-2 | Wellemeyer (12-9) | 40349 | 79-77 |
| September 23 | @ Cardinals | 7-4 | Johnson (10-10) | 40013 | 79-78 |
| September 24 | @ Cardinals | 4-2 | Scherzer (0-4) | 40029 | 79-79 |
| September 25 | @ Cardinals | 12-3 | Rosales (1-1) | 40502 | 79-80 |