2008 Houston Astros season Game log June

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| June 14 | Yankees † | 8–4 | Rodríguez (2–3) | 43409 | 33–36 |
| June 15 | Yankees † | 13–0 | Oswalt (5–7) | 43165 | 33–37 |
| June 17 | @ Orioles † | 6–5 | Brocail (2–2) | 21535 | 33–38 |
| June 18 | @ Orioles † | 2 – 1 (10) | Valverde (4–2) | 21112 | 33–39 |
| June 19 | @ Orioles † | 7–5 | Chacón (2–3) | 31480 | 33–40 |
| June 20 | @ Rays † | 4–3 | Garza (5–4) | 14741 | 34–40 |
| June 21 | @ Rays † | 4–3 | Brocail (2–3) | 29953 | 34–41 |
| June 22 | @ Rays † | 3–2 | Kazmir (6–3) | 19778 | 35–41 |
| June 24 | Rangers † | 4–3 | Hurley (0–1) | 40052 | 36–41 |
| June 25 | Rangers † | 3–2 | Oswalt (6–8) | 32567 | 36–42 |
| June 26 | Rangers † | 7–2 | Millwood (5–4) | 36506 | 37–42 |