2000 Arizona Cardinals season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 3, 2000 | at New York Giants | L 21-16 | 77434 |
| 2 | September 10, 2000 | Dallas Cowboys | W 32-31 | 66008 |
| 3 | Bye | Bye | Bye | Bye |
| 4 | September 24, 2000 | Green Bay Packers | L 29-3 | 71801 |
| 5 | October 1, 2000 | at San Francisco 49ers | L 27-20 | 66985 |
| 6 | October 8, 2000 | Cleveland Browns | W 29-21 | 44296 |
| 7 | October 15, 2000 | Philadelphia Eagles | L 33-14 | 38293 |
| 8 | October 22, 2000 | at Dallas Cowboys | L 48-7 | 62981 |
| 9 | October 29, 2000 | New Orleans Saints | L 21-10 | 35286 |
| 10 | November 5, 2000 | Washington Redskins | W 16-15 | 52244 |