1986 Buffalo Bills season NFL Draft NFL Draft

| Round | Pick_ | Player | Position_ | College |
|---|---|---|---|---|
| 1 | 16 | Ronnie Harmon | Running back | Iowa |
| 1 | 20 | Will Wolford | Offensive Tackle | Vanderbilt |
| 3 | 77 | Leonard Burton | Center | South Carolina |
| 5 | 111 | Carl Byrum | Running back | Mississippi Valley State |
| 7 | 168 | Bob Williams | Tight end | Penn State |
| 7 | 178 | Mark Pike | Linebacker | Georgia Tech |
| 7 | 180 | Butch Rolle | Tight end | Michigan State |
| 8 | 202 | Tony Furjanic | Linebacker | Notre Dame |
| 9 | 222 | Reggie Bynum | Wide receiver | Oregon State |
| 10 | 251 | Guy Teafatiller | Defensive tackle | Illinois |
| 11 | 278 | Tony Garbarczyk | Defensive tackle | Wake Forest |
| 11 | 282 | Billy Witt | Defensive end | North Alabama |
| 12 | 313 | Brian McClure | Quarterback | Bowling Green |
| 12 | 331 | Derek Christian | Linebacker | West Virginia Tech |