1991 NCAA Women's Division I Basketball Tournament First and second rounds First and second rounds

| Region | Host_ | Venue | City | State_ |
|---|---|---|---|---|
| East | Providence College | Alumni Hall (Providence) | Providence | Rhode Island |
| East | Rutgers University | Louis Brown Athletic Center | Piscataway | New Jersey |
| East | James Madison University | James Madison University Convocation Center | Harrisonburg | Virginia |
| East | University of Richmond | Robins Center | Richmond | North Carolina |
| East | Clemson University | Littlejohn Coliseum | Clemson | South Carolina |
| East | University of Connecticut | Harry A. Gampel Pavilion | Storrs | Connecticut |
| East | Pennsylvania State University | Recreation Building (Rec Hall) | University Park | Pennsylvania |
| East | North Carolina State University | Reynolds Coliseum | Raleigh | North Carolina |
| Mideast | Florida State University | Tully Gymnasium | Tallahassee | Florida |
| Mideast | Vanderbilt University | Memorial Gymnasium (Vanderbilt University) | Nashville | Tennessee |