1965 San Diego Chargers season Season schedule Season schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 11, 1965 | Denver Broncos | W 34–31 | 27022 |
| 2 | September 19, 1965 | at Oakland Raiders | W 17–6 | 21406 |
| 3 | September 26, 1965 | Kansas City Chiefs | T 10–10 | 28126 |
| 4 | October 3, 1965 | Houston Oilers | W 31–14 | 28190 |
| 5 | October 10, 1965 | at Buffalo Bills | W 34–3 | 45260 |
| 6 | October 17, 1965 | at Boston Patriots | T 13–13 | 20924 |
| 7 | October 23, 1965 | at New York Jets | W 34–9 | 60679 |
| 8 | October 31, 1965 | Boston Patriots | L 22–6 | 33366 |
| 9 | November 7, 1965 | at Denver Broncos | W 35–21 | 33073 |
| 10 | November 14, 1965 | at Kansas City Chiefs | L 31–7 | 21968 |