2008 Houston Astros season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 13 | Marlins | 5–1 | Badenhop (0–1) | 29766 | 5–8 |
| April 15 | @ Phillies | 3–4 | Valverde (2–1) | 34609 | 5–9 |
| April 16 | @ Phillies | 2–1 | Kendrick (1–2) | 31644 | 6–9 |
| April 17 | @ Phillies | 2–10 | Backe (1–2) | 33526 | 6–10 |
| April 18 | Rockies | 11–5 | Sampson (0–2) | 34272 | 6–11 |
| April 19 | Rockies | 2–3 | Villarreal (0–3) | 34540 | 6–12 |
| April 20 | Rockies | 6–4 | Fuentes (0–1) | 35286 | 7–12 |
| April 21 | Padres | 10–3 | Germano (0–2) | 28600 | 8–12 |
| April 22 | Padres | 11–7 | Bell (0–2) | 33434 | 9–12 |
| April 23 | @ Reds | 9–3 | Arroyo (0–3) | 16017 | 10–12 |
| April 24 | @ Reds | 5–3 | Cueto (3) | 17403 | 11–12 |
| April 25 | @ Cardinals | 3–2 | Isringhausen (1–2) | 41193 | 12–12 |