2005–06 U.S. Città di Palermo season UEFA Cup UEFA Cup

| Date_and_time | Round | Opponent | Venue | Result_ | Attendance |
|---|---|---|---|---|---|
| February 16, 2006 – 20.45 | Round of 32 – 1st Leg | Slavia Praha | Away | Lost 1-2 | 6706 |
| February 23, 2006 – 16.00 | Round of 32 – 2nd Leg | Slavia Praha | Home | Won 1-0 | 8063 |
| March 9, 2006 – 18.00 | Round of 16 – 1st Leg | Schalke 04 | Home | Won 1-0 | 10581 |
| March 16, 2006 – 20.30 | Round of 16 – 2nd Leg | Schalke 04 | Away | Lost 0-3 | 52151 |