2008 Buffalo Bills season Schedule Schedule

| Week | Date_ | Kickoff_ET_ | Opponent | Result_ | Record | Game_Site | NFL_com_Recap |
|---|---|---|---|---|---|---|---|
| 1 | Sunday September 7 | 1:00 PM | Seattle Seahawks | W 34–10 | 1–0 | Ralph Wilson Stadium | Recap |
| 2 | Sunday September 14 | 1:00 PM | at Jacksonville Jaguars | W 20–16 | 2–0 | Jacksonville Municipal Stadium | Recap |
| 3 | Sunday September 21 | 1:00 PM | Oakland Raiders | W 24–23 | 3–0 | Ralph Wilson Stadium | Recap |
| 4 | Sunday September 28 | 4:05 PM | at St. Louis Rams | W 31–14 | 4–0 | Edward Jones Dome | Recap |
| 5 | Sunday October 5 | 4:15 PM | at Arizona Cardinals | L 41–17 | 4–1 | University of Phoenix Stadium | Recap |
| 6 | Bye Week | Bye Week | Bye Week | Bye Week | Bye Week | Bye Week | Bye Week |