1990 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Record | Game_Site | Attendance |
|---|---|---|---|---|---|---|
| 9 | November 4, 1990 | at Cleveland Browns | W 42–0 | 7–1 | Cleveland Municipal Stadium | 78331 |
| 10 | November 11, 1990 | Phoenix Cardinals | W 45–14 | 8–1 | Rich Stadium | 74904 |
| 11 | November 18, 1990 | New England Patriots | W 14–0 | 9–1 | Rich Stadium | 74729 |
| 12 | November 25, 1990 | at Houston Oilers | L 27–24 | 9–2 | Houston Astrodome | 60130 |
| 13 | December 2, 1990 | Philadelphia Eagles | W 30–23 | 10–2 | Rich Stadium | 79320 |
| 14 | December 9, 1990 | at Indianapolis Colts | W 31–7 | 11–2 | Hoosier Dome | 53268 |
| 15 | December 15, 1990 | at New York Giants | W 17–13 | 12–2 | Giants Stadium | 66893 |
| 16 | December 22, 1990 | Miami Dolphins | W 24–14 | 13–2 | Rich Stadium | 80325 |
| 17 | December 30, 1990 | at Washington Redskins | L 29–14 | 13–3 | RFK Stadium | 52397 |