1991 New England Patriots season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 1, 1991 | at Indianapolis Colts | W 16–7 | 49961 |
| 2 | September 8, 1991 | Cleveland Browns | L 20–0 | 35377 |
| 3 | September 15, 1991 | at Pittsburgh Steelers | L 20–6 | 53703 |
| 4 | September 22, 1991 | Houston Oilers | W 24–20 | 30702 |
| 5 | September 29, 1991 | at Phoenix Cardinals | L 24–10 | 26043 |
| 6 | October 6, 1991 | Miami Dolphins | L 20–10 | 49749 |
| 7 | Bye | Bye | Bye | Bye |
| 8 | October 20, 1991 | Minnesota Vikings | W 26–23 | 45367 |
| 9 | October 27, 1991 | Denver Broncos | L 9–6 | 43994 |
| 10 | November 3, 1991 | at Buffalo Bills | L 22–17 | 78278 |
| 11 | November 10, 1991 | at Miami Dolphins | L 30–20 | 56065 |