Most lethal American battles Battles Battles

| Battle_Siege_or_Offensive | Conflict | Dates | Estimated_number_of_Americans_killed_ |
|---|---|---|---|
| Battle of Guadalcanal | World War II | August 7, 1942 to February 9, 1943 | 7,100 killed |
| Battle of Iwo Jima | World War II | February 16 to March 26, 1945 | 7,000 killed |
| Battle of Anzio | World War II | January 22 to June 5, 1944 | 5,538 killed |
| Battle of Pusan Perimeter | Korean War | August to September, 1950 | 4,599 killed |
| Battle of Spotsylvania | American Civil War | May 8 to May 21, 1864 | 4,192 killed (2,725 Union and 1,467 Confederacy) |
| Battle of Chickamauga | American Civil War | September 19 to September 20, 1863 | 3,969 killed (1,657 Union and 2,312 Confederacy) |
| Battle of the Wilderness | American Civil War | May 5 to May 7, 1864 | 3,741 killed (2,246 Union and 1,495 Confederacy) |