2008 Minnesota Twins season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 20 | Indians | 2 - 1 (10) | Pérez (0-1) | 27703 | 9-10 |
| April 22 | @ Athletics | 5 - 4 | Blanton (1-4) | 10267 | 10-10 |
| April 23 | @ Athletics | 3 - 0 | Bonser (1-4) | 15242 | 10-11 |
| April 24 | @ Athletics | 11 - 2 | Liriano (0-3) | 12593 | 10-12 |
| April 25 | @ Rangers | 6 - 5 (10) | Rincón (2-1) | 19016 | 10-13 |
| April 26 | @ Rangers | 12 - 6 | Wright (1-1) | 33053 | 11-13 |
| April 27 | @ Rangers | 10 - 0 | Hernández (3-1) | 19911 | 11-14 |
| April 29 | White Sox | 3 - 1 | Floyd (2-1) | 20891 | 12-14 |
| April 30 | White Sox | 4 - 3 | Wassermann (0-1) | 19137 | 13-14 |