2008 New York Yankees season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 1 | Blue Jays | 3–2 | Halladay (0–1) | 55112 | 1–0 |
| April 2 | Blue Jays | 5–2 | Mussina (0–1) | 48544 | 1–1 |
| April 3 | Blue Jays | 3–2 | Wolfe (0–1) | 47785 | 2–1 |
| April 4 | Rays | 13–4 | Kennedy (0–1) | 49255 | 2–2 |
| April 5 | Rays | 6–3 | Pettitte (0–1) | 52247 | 2–3 |
| April 6 | Rays | 2–0 | Shields (1–1) | 51279 | 3–3 |
| April 7 | Rays | 6–1 | Hammel (0–1) | 41302 | 4–3 |
| April 8 | @ Royals | 5–2 | Hughes (0–1) | 37296 | 4–4 |
| April 9 | @ Royals | 4–0 | Farnsworth (0–1) | 19007 | 4–5 |
| April 10 | @ Royals | 6–1 | Bale (0–2) | 16143 | 5–5 |
| April 11 | @ Red Sox | 4–1 | Timlin (0–1) | 37624 | 6–5 |