2008 Chicago White Sox season Game log September

| Date_ | Opponent | Score | Loss | Time_ | Att_ | Record |
|---|---|---|---|---|---|---|
| September 13 | Tigers | Postponed (rain), rescheduled for September 29 | Postponed (rain), rescheduled for September 29 | Postponed (rain), rescheduled for September 29 | Postponed (rain), rescheduled for September 29 | Postponed (rain), rescheduled for September 29 |
| September 14 | Tigers | 4–2 | Verlander (10–16) | 2:17 | N/A | 82–65 |
| September 14 | Tigers | 11–7 | Seay (1–2) | 3:16 | 28238 | 83–65 |
| September 15 | @ Yankees | 2–4 | Wassermann (1–2) | 2:39 | 53236 | 83–66 |
| September 16 | @ Yankees | 6–2 | Pettitte (13–14) | 3:02 | 52558 | 84–66 |
| September 17 | @ Yankees | 1–5 | Richard (2–5) | 2:40 | 52671 | 84–67 |
| September 18 | @ Yankees | 2–9 | Vázquez (12–14) | 3:08 | 53152 | 84–68 |
| September 19 | @ Royals | 9–4 | Bannister (8–16) | 2:40 | 26049 | 85–68 |
| September 20 | @ Royals | 2–5 | Floyd (16–8) | 2:32 | 23754 | 85–69 |
| September 21 | @ Royals | 3–0 | Duckworth (3–2) | 2:28 | 16920 | 86–69 |
| September 23 | @ Twins | 3–9 | Vázquez (12–15) | 2:43 | 35225 | 86–70 |