2008 Chicago White Sox season Game log April

| Date_ | Opponent | Score | Loss | Time_ | Att_ | Record |
|---|---|---|---|---|---|---|
| April 22 | Yankees | 5–9 | Contreras (1–2) | 3:44 | 25012 | 11–8 |
| April 23 | Yankees | 4–6 | Vázquez (3–2) | 3:06 | 27751 | 11–9 |
| April 24 | Yankees | 7–6 | Chamberlain (1–1) | 3:05 | 27243 | 12–9 |
| April 25 | Orioles | Postponed (rain) Rescheduled for April 26 | Postponed (rain) Rescheduled for April 26 | Postponed (rain) Rescheduled for April 26 | Postponed (rain) Rescheduled for April 26 | Postponed (rain) Rescheduled for April 26 |
| April 26 | Orioles | 1–5 | Danks (2–2) | 2:41 | 23043 | 12–10 |
| April 26 | Orioles | 6–5 | Bierd (0–1) | 3:28 | 34757 | 13–10 |
| April 27 | Orioles | 6–1 | Guthrie (0–3) | 2:58 | 29756 | 14–10 |
| April 28 | Orioles | 3 – 4 (14) | H. Ramírez (1–3) | 4:42 | 17,367 * | 14–11 |