1978 San Francisco 49ers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 11 | November 12, 1978 | St. Louis Cardinals | L 16-10 | 33155 |
| 12 | November 19, 1978 | Los Angeles Rams | L 31-28 | 45022 |
| 13 | November 27, 1978 | Pittsburgh Steelers | L 24-7 | 51657 |
| 14 | December 3, 1978 | at New Orleans Saints | L 24-13 | 50068 |
| 15 | December 10, 1978 | Tampa Bay Buccaneers | W 6-3 | 30931 |
| 16 | December 17, 1978 | at Detroit Lions | L 33-14 | 56674 |