1959 San Francisco 49ers season Schedule Schedule

| Date_ | Visitor | Score | Home | Record | Attendance |
|---|---|---|---|---|---|
| September 27 | Philadelphia Eagles | 24-14 | San Francisco 49ers | 1-0-0 | 41697 |
| October 4 | Los Angeles Rams | 34-0 | San Francisco 49ers | 2-0-0 | 56028 |
| October 11 | San Francisco 49ers | 21-20 | Green Bay Packers | 2-1-0 | 32150 |
| October 18 | San Francisco 49ers | 34-13 | Detroit Lions | 3-1-0 | 52585 |
| October 25 | Chicago Bears | 20-17 | San Francisco 49ers | 4-1-0 | 59045 |
| November 1 | Detroit Lions | 33-7 | San Francisco 49ers | 5-1-0 | 59064 |
| November 8 | San Francisco 49ers | 24-16 | Los Angeles Rams | 6-1-0 | 94276 |
| November 15 | San Francisco 49ers | 14-3 | Chicago Bears | 6-2-0 | 42157 |
| November 22 | San Francisco 49ers | 45-14 | Baltimore Colts | 6-3-0 | 56007 |