2008 Buffalo Bills season Schedule Schedule

| Week | Date_ | Kickoff_ET_ | Opponent | Result_ | Record | Game_Site | NFL_com_Recap |
|---|---|---|---|---|---|---|---|
| 7 | Sunday October 19 | 1:00 PM | San Diego Chargers | W 23–14 | 5–1 | Ralph Wilson Stadium | Recap |
| 8 | Sunday October 26 | 1:00 PM | at Miami Dolphins | L 25–16 | 5–2 | Dolphin Stadium | Recap |
| 9 | Sunday November 2 | 1:00 PM | New York Jets | L 26–17 | 5–3 | Ralph Wilson Stadium | Recap |
| 10 | Sunday November 9 | 1:00 PM | at New England Patriots | L 20–10 | 5–4 | Gillette Stadium | Recap |
| 11 | Monday November 17 | 8:30 PM | Cleveland Browns | L 29–27 | 5–5 | Ralph Wilson Stadium | Recap |
| 12 | Sunday November 23 | 1:00 PM | at Kansas City Chiefs | W 54–31 | 6–5 | Arrowhead Stadium | Recap |
| 13 | Sunday November 30 | 1:00 PM | San Francisco 49ers | L 10–3 | 6–6 | Ralph Wilson Stadium | Recap |