1980–81 FA Cup Sixth Round Proper Sixth Round Proper

| Tie_no | Home_team | Score | Away_team | Date_ |
|---|---|---|---|---|
| 1 | Nottingham Forest | 3–3 | Ipswich Town | 7 March 1981 |
| Replay | Ipswich Town | 1–0 | Nottingham Forest | 10 March 1981 |
| 2 | Middlesbrough | 1–1 | Wolverhampton Wanderers | 7 March 1981 |
| Replay | Wolverhampton Wanderers | 3–1 | Middlesbrough | 10 March 1981 |
| 3 | Everton | 2–2 | Manchester City | 7 March 1981 |
| Replay | Manchester City | 3–1 | Everton | 11 March 1981 |
| 4 | Tottenham Hotspur | 2–0 | Exeter City | 7 March 1981 |