Sister Act (musical) Major casts Major casts

| Character_ | Original_West_End_Cast | Original_Broadway_Cast | First_UK_Tour_Cast | First_US_Tour_Cast |
|---|---|---|---|---|
| Deloris Van Cartier / Sister Mary Clarence | Patina Miller | Patina Miller | Cynthia Erivo | Ta`Rea Campbell |
| Mother Superior | Sheila Hancock | Victoria Clark | Denise Black | Hollis Resnik |
| Curtis Shank | Chris Jarman | Kingsley Leggs | Cavin Cornwall | Kingsley Leggs |
| Lt. Eddie Souther | Ako Mitchell | Chester Gregory | Edward Baruwa | E. Clayton Cornelious |
| Sister Mary Robert | Katie Rowley Jones | Marla Mindelle | Julie Atherton | Lael Van Keuren |
| Sister Mary Patrick | Claire Greenway | Sarah Bolt | Laurie Scarth | Florrie Bagel |
| Sister Mary Lazarus | Julia Sutton | Audrie Neenan | Jacqueline Clarke | Diane J. Findlay |
| Monsignor Howard | Ian Lavender | Fred Applegate | Michael Starke | Richard Pruitt |