1959 New York Giants season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance_ |
|---|---|---|---|---|
| 1 | September 26, 1959 | at Los Angeles Rams | W 23–21 | 71297 |
| 2 | October 4, 1959 | at Philadelphia Eagles | L 49–21 | 27023 |
| 3 | October 11, 1959 | at Cleveland Browns | W 10–6 | 65534 |
| 4 | October 18, 1959 | Philadelphia Eagles | W 24–7 | 68783 |
| 5 | October 25, 1959 | at Pittsburgh Steelers | W 21–16 | 33596 |
| 6 | November 1, 1959 | Green Bay Packers | W 20–3 | 68837 |
| 7 | November 8, 1959 | Chicago Cardinals | W 9–3 | 56779 |
| 8 | November 15, 1959 | Pittsburgh Steelers | L 14–9 | 66786 |
| 9 | November 22, 1959 | at Chicago Cardinals (Bloomington, MN) | W 30–20 | 26625 |
| 10 | November 29, 1959 | Washington Redskins | W 45–14 | 60982 |