1981 Denver Broncos season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Game_site | Record | Attendance |
|---|---|---|---|---|---|---|
| 1 | September 6 | Oakland Raiders | W 9–7 | Mile High Stadium | 1–0 | 74796 |
| 2 | September 13 | at Seattle Seahawks | L 10–13 | Kingdome | 1–1 | 58513 |
| 3 | September 20 | Baltimore Colts | W 28–10 | Mile High Stadium | 2–1 | 74804 |
| 4 | September 27 | San Diego Chargers | W 42–24 | Mile High Stadium | 3–1 | 74822 |
| 5 | October 4 | at Oakland Raiders | W 17–0 | Oakland-Alameda County Coliseum | 4–1 | 51035 |
| 6 | October 11 | Detroit Lions | W 27–21 | Mile High Stadium | 5–1 | 74816 |
| 7 | October 18 | at Kansas City Chiefs | L 14–28 | Arrowhead Stadium | 5–2 | 74672 |
| 8 | October 25 | at Buffalo Bills | L 7–9 | Rich Stadium | 5–3 | 77757 |