2008 New England Patriots season Regular season Regular season

| Week | Kickoff | Date_ | Opponent | Result_ | Record | Game_Site | NFL_com_Recap |
|---|---|---|---|---|---|---|---|
| 1 | 1:00 PM EDT | September 7, 2008 | Kansas City Chiefs | W 17–10 | 1–0 | Gillette Stadium | Recap |
| 2 | 4:15 PM EDT | September 14, 2008 | New York Jets | W 19–10 | 2–0 | Giants Stadium | Recap |
| 3 | 1:00 PM EDT | September 21, 2008 | Miami Dolphins | L 13–38 | 2–1 | Gillette Stadium | Recap |
| 4 | Bye | Bye | Bye | Bye | Bye | Bye | Bye |
| 5 | 4:15 PM EDT | October 5, 2008 | San Francisco 49ers | W 30–21 | 3–1 | Candlestick Park | Recap |
| 6 | 8:15 PM EDT | October 12, 2008 | San Diego Chargers | L 10–30 | 3–2 | Qualcomm Stadium | Recap |