List of highway route numbers in Oregon Mainline routes Mainline routes

| Number_ | South_west_end | North_east_end | Formed | Eliminated_ |
|---|---|---|---|---|
| U.S. Route 95 Spur | OR 201 south of Huntington | US 95S in Weiser, ID | 1980 |  |
| U.S. Route 395 | US 395 towards Alturas, CA | I-82/US 395 towards Tri-Cities, WA | 1934 |  |
| U.S. Route 97 | US 97 towards Weed, CA | US 97 towards Yakima, WA | 1926 |  |
| U.S. Route 97 Business | US 97 in Klamath Falls | US 97 in Klamath Falls | 1980s |  |
| U.S. Route 97 Business | US 97 in Bend | US 20/US 97 in Bend | 1980s |  |
| U.S. Route 197 | US 97 at Shaniko Junction | US 197 towards Dallesport, WA | 1952 |  |
| U.S. Route 99 | Towards Weed, CA | Vancouver, WA | 1926 | 1972 |
| U.S. Route 99E | OR 99/OR 99W in Junction City | OR 99/OR 99W in Portland | 1928 | 1972 |