List of largest airlines in Central America & the Caribbean Current destination number Current destination number

| Rank_ | Airline | Country | Destination_number | Remarks |
|---|---|---|---|---|
| 1 | Cubana de Aviación | Cuba | 35 | Operational since 1929 |
| 2 | LIAT | Antigua and Barbuda | 21 | Second Largest Airline in the Caribbean |
| 3 | Caribbean Airlines | Trinidad and Tobago | 19 | Largest Airline in the Caribbean |
| 4 | InselAir | Curacao | 16 | Operational since 2006 |
| 5 | Dutch Antilles Express | Curacao | 9 | More destination to come |
| 6 | Air Jamaica | Trinidad and Tobago | 7 | Parent Company is Caribbean Airlines |
| 7 | Tiara Air | Aruba | 6 | Aruba`s national airline |