1949 San Francisco 49ers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Score | Record |
|---|---|---|---|---|---|
| 1 | August 28, 1949 | Baltimore Colts | W | 31-17 | 1-0 |
| 2 | September 4, 1949 | Chicago Hornets | W | 42-7 | 2-0 |
| 3 | September 18, 1949 | Los Angeles Dons | W | 42-14 | 3-0 |
| 4 | September 25, 1949 | at Buffalo Bills | L | 28-17 | 3-1 |
| 5 | September 30, 1949 | Chicago Hornets | W | 42-24 | 4-1 |
| 6 | October 9, 1949 | Cleveland Browns | W | 56-28 | 5-1 |
| 7 | October 16, 1949 | Buffalo Bills | W | 51-7 | 6-1 |
| 8 | October 23, 1949 | at New York Yankees | L | 24-3 | 6-2 |
| 9 | October 30, 1949 | at Cleveland Browns | L | 30-28 | 6-3 |
| 10 | November 6, 1949 | at Baltimore Colts | W | 28-10 | 7-3 |