2006 Chicago Cubs season Game log June

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| June 2 | @ Cardinals | 5–4 | Hancock (1–2) | 45799 | 21–32 |
| June 3 | @ Cardinals | 8–5 | Mulder (5–4) | 45820 | 22–32 |
| June 4 | @ Cardinals | 9–6 | Maddux (6–5) | 45753 | 22–33 |
| June 5 | @ Astros | 8–0 | Buchholz (3–5) | 32814 | 23–33 |
| June 6 | @ Astros | 4–1 | Wood (1–2) | 35903 | 23–34 |
| June 7 | @ Astros | 1–0 | Marshall (3–4) | 42492 | 23–35 |
| June 8 | @ Reds | 7–1 | Rusch (2–6) | 26059 | 23–36 |
| June 9 | @ Reds | 6–5 | Ramirez (2–5) | 41064 | 24–36 |
| June 10 | @ Reds | 4–2 | Claussen (3–7) | 34141 | 25–36 |
| June 11 | @ Reds | 9–3 | Milton (4–3) | 27250 | 26–36 |
| June 13 | Astros | 9–2 | Marshall (3–5) | 40563 | 26–37 |