1977–78 Copa del Rey Second round Second round

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg_ |
|---|---|---|---|---|
| Jaén | 1–4 | Real Unión | 1–1 | 0–3 |
| Ontinyent | 1–0 | Torrejón | 1–0 | 0–0 |
| Girona | 5–1 | Alcoyano | 3–0 | 2–1 |
| Valencia Mestalla | 4–2 | Sevilla Atlético | 3–0 | 1–2 |
| Español Raspeig | 0–1 | Mirandés | 0–0 | 0–1 |
| Toledo | 3–3 (4–3 p) | Badajoz | 2–0 | 1–3 |
| Talavera | 2–0 | Arosa | 2–0 | 0–0 |
| Sariñena | 1–5 | Rayo Cantabria | 0–2 | 1–3 |
| San Fernando | 5–1 | Nàstic Tarragona | 4–1 | 1–0 |
| Sevilla | 4–1 | Sant Andreu | 2–0 | 2–1 |
| Orihuela | 0–3 | Alavés | 0–1 | 0–2 |
| Oviedo | 4–1 | Cultural Leonesa | 2–0 | 2–1 |
| Langreo | 1–3 | Granada | 1–0 | 0–3 |
| Racing Ferrol | 3–5 | Real Murcia | 2–0 | 1–5 |
| Levante | 9–2 | Moscardó | 5–0 | 4–2 |
| Real Sociedad | 3–3 (8–7 p) | Xerez | 1–1 | 2–2 |
| Marbella | 4–3 | Gimnástica Torrelavega | 4–1 | 0–2 |