List of islands of the United States by area Islands   ( –  km ) Islands   ( –  km )

| Rank_ | Island_s_Name | Area_sqmi | Area_km_2_ | Location_ | Population_2000 |
|---|---|---|---|---|---|
| 43 | Lāna ʻ i | 141 | 364 | Hawaii | 3193 |
| 44 | St. Matthew Island | 137 | 354 | Alaska | 0 |
| 45 | Annette Island | 132 | 342 | Alaska | 1447 |
| 46 | Akutan Island | 129 | 334 | Alaska | 713 |
| 47 | Drummond Island | 125 | 324 | Michigan | 1058 |
| 48 | Hagemeister Island | 120 | 312 | Alaska | 0 |
| 49 | Nagai Island | 120 | 310 | Alaska | 0 |
| 50 | Amchitka | 119 | 309 | Alaska | 0 |
| 51 | Sitkalidak Island | 119 | 309 | Alaska | 0 |
| 52 | Mount Desert Island | 108 | 280 | Maine | 10424 |
| 53 | Kiska | 107 | 278 | Alaska | 0 |
| 54 | Knight Island | 101 | 260 | Alaska | 0 |
| 55 | Marsh Island | 100 | 259 | Louisiana | 0 |
| 56 | Santa Cruz Island | 98 | 254 | California | 2 |
| 57 | Gravina Island | 95 | 245 | Alaska | 50 |