2005 Houston Texans season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 11, 2005 | at Buffalo Bills | L 22–7 | 71781 |
| 2 | September 18, 2005 | Pittsburgh Steelers | L 27–7 | 70742 |
| 3 | Bye | Bye | Bye | Bye |
| 4 | October 2, 2005 | at Cincinnati Bengals | L 16–10 | 65714 |
| 5 | October 9, 2005 | Tennessee Titans | L 34–20 | 70430 |
| 6 | October 16, 2005 | at Seattle Seahawks | L 42–10 | 66196 |
| 7 | October 23, 2005 | Indianapolis Colts | L 38–20 | 70621 |
| 8 | October 30, 2005 | Cleveland Browns | W 19–16 | 70064 |
| 9 | November 6, 2005 | at Jacksonville Jaguars | L 21–14 | 64613 |
| 10 | November 13, 2005 | at Indianapolis Colts | L 31–17 | 57209 |