1981 San Francisco 49ers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 11 | November 15, 1981 | Cleveland Browns | L 12-15 | 52455 |
| 12 | November 22, 1981 | at Los Angeles Rams | W 33-31 | 63456 |
| 13 | November 29, 1981 | New York Giants | W 17-10 | 57186 |
| 14 | December 6, 1981 | at Cincinnati Bengals | W 21-3 | 56796 |
| 15 | December 13, 1981 | Houston Oilers | W 28-6 | 55707 |
| 16 | December 20, 1981 | at New Orleans Saints | W 21-17 | 43639 |