1981 Buffalo Bills season NFL Draft NFL Draft

| Round | Pick_ | Player | Position_ | College |
|---|---|---|---|---|
| 1 | 28 | Booker Moore | Running back | Penn State |
| 2 | 49 | Chris Williams | Defensive back | LSU |
| 2 | 49 | Byron Franklin | Wide receiver | Auburn |
| 3 | 76 | Mike Mosley | Wide receiver | Texas A&M |
| 3 | 84 | Robert Geathers | Defensive tackle | South Carolina State |
| 5 | 135 | Calvin Clark | Defensive end | Purdue |
| 6 | 161 | Robert Holt | Wide receiver | Baylor |
| 7 | 188 | Steve Doolittle | Linebacker | Colorado |
| 9 | 241 | Robb Riddick | Running back | Millersville (PA) |
| 10 | 272 | Justin Cross | Offensive tackle | Western Colorado |
| 11 | 299 | Buster Barnett | Tight end | Jackson State |
| 12 | 326 | Keith Clark | Linebacker | Memphis State |