1959 Chicago Cardinals season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Venue | Attendance |
|---|---|---|---|---|---|
| 1 | September 27, 1959 | Washington Redskins | W 49-21 | Soldier Field | 21892 |
| 2 | October 4, 1959 | Cleveland Browns | L 34-7 | Soldier Field | 19935 |
| 3 | October 11, 1959 | at Washington Redskins | L 23-14 | Griffith Stadium | 25937 |
| 4 | October 18, 1959 | at Cleveland Browns | L 17-7 | Cleveland Stadium | 46422 |
| 5 | October 25, 1959 | Philadelphia Eagles | L 28-24 | Metropolitan Stadium | 20112 |
| 6 | November 1, 1959 | Pittsburgh Steelers | W 45-24 | Soldier Field | 23187 |
| 7 | November 8, 1959 | at New York Giants | L 9-3 | Yankee Stadium | 56779 |
| 8 | November 15, 1959 | at Philadelphia Eagles | L 27-17 | Franklin Field | 28887 |