2007–08 Copa Federación de España Round of 16 Round of 16

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Racing B | 2–3 | Noja | 2–1 | 0–2 |
| Espanyol B | 13–0 | ADF Logroñés | 2–0 | 11–0 |
| Real Madrid C | 1–2 | SS Reyes | 1–0 | 0–2 |
| Reus | 3–0 | Haro | 3–0 | 0–0 |
| Ferriolense | 2–5 | Ourense | 2–1 | 0–4 |
| Tuilla | 1–0 | Lemona | 0–0 | 1–0 |
| Marbella | 1–0 | Don Benito | 1–0 | 0–0 |
| Linares | 3–5 | Mazarrón | 1–1 | 2–4 |