1981 VFL season Round 21 Round 21

| Home_team | Home_team_score | Away_team | Away_team_score | Venue | Crowd | Date_ |
|---|---|---|---|---|---|---|
| Melbourne | 15.9 (99) | Richmond | 17.14 (116) | MCG | 19567 | 22 August 1981 |
| Fitzroy | 14.18 (102) | St Kilda | 9.10 (64) | Junction Oval | 12130 | 22 August 1981 |
| Essendon | 26.23 (179) | South Melbourne | 10.8 (68) | Windy Hill | 18773 | 22 August 1981 |
| Collingwood | 22.17 (149) | Hawthorn | 11.10 (76) | Victoria Park | 26680 | 22 August 1981 |
| Geelong | 18.20 (128) | Footscray | 8.11 (59) | Kardinia Park | 17573 | 22 August 1981 |
| Carlton | 12.12 (84) | North Melbourne | 8.14 (62) | VFL Park | 25544 | 22 August 1981 |