2000–01 Sheffield Wednesday F.C. season Football League First Division Football League First Division

| Date_ | Opponent | Venue | Result_ | Attendance |
|---|---|---|---|---|
| 30 December 2000 | Huddersfield Town | A | 0-0 | 18931 |
| 1 January 2001 | Grimsby Town | H | 1-0 | 17004 |
| 13 January 2001 | Blackburn Rovers | A | 0-2 | 19308 |
| 20 January 2001 | Bolton Wanderers | H | 0-3 | 17638 |
| 3 February 2001 | Watford | H | 2-3 | 16134 |
| 10 February 2001 | Wimbledon | A | 1-4 | 6741 |
| 13 February 2001 | Tranmere Rovers | H | 1-0 | 15444 |
| 21 February 2001 | Nottingham Forest | A | 1-0 | 23266 |
| 24 February 2001 | Preston North End | A | 0-2 | 14379 |
| 3 March 2001 | Gillingham | H | 2-1 | 18702 |
| 7 March 2001 | Portsmouth | H | 0-0 | 20503 |
| 10 March 2001 | West Bromwich Albion | A | 2-1 | 18662 |
| 17 March 2001 | Burnley | H | 2-0 | 20184 |