2008 San Francisco 49ers season Regular season Regular season

| Week | Date_ | Time_PT_ | Opponent | Result_ | Record | Game_site |
|---|---|---|---|---|---|---|
| 15 | December 14, 2008 | 10 a.m. | at Miami Dolphins | L 9-14 | 5-9 | Land Shark Stadium |
| 16 | December 21, 2008 | 10 a.m. | at St. Louis Rams | W 17-16 | 6-9 | Edward Jones Dome |
| 17 | December 28, 2008 | 1:15 p.m. | Washington Redskins | W 27-24 | 7-9 | Candlestick Park |