2001 Cleveland Indians season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 9 | White Sox | 9 - 8 | Foulke (3-9) | 42377 | 82-61 |
| September 10 | White Sox | 7 - 1 | Colón (12-11) | 38244 | 82-62 |
| September 18 | Royals | 11 - 2 | Durbin (7-15) | 34795 | 83-62 |
| September 19 | Royals | 11 - 3 | Suppan (9-12) | 31357 | 84-62 |
| September 20 | Royals | 4 - 2 | Drese (1-1) | 33912 | 84-63 |
| September 21 | @ Twins | 6 - 2 | Sabathia (15-5) | 20038 | 84-64 |
| September 22 | @ Twins | 4 - 2 | Radke (13-10) | 33733 | 85-64 |
| September 23 | @ Twins | 4 - 2 | Milton (14-7) | 21928 | 86-64 |
| September 24 | Blue Jays | 3 - 2 (11) | Báez (5-2) | 32425 | 86-65 |
| September 25 | Blue Jays | 11 - 7 | Plesac (4-5) | 35729 | 87-65 |