USA Today All-USA high school football team 2010 team First Team Defense

| Player | Position_ | School | Hometown | College |
|---|---|---|---|---|
| Jadeveon Clowney | Defensive line | South Pointe High School | Rock Hill, South Carolina | South Carolina |
| Tim Jernigan | Defensive line | Columbia High School | Lake City, Florida | Florida State |
| Anthony Johnson | Defensive line | O. Perry Walker High School | New Orleans, Louisiana | LSU |
| Viliami Moala | Defensive line | Grant High School | Sacramento, California | California |
| Ray Drew | Defensive line | Thomas County Central High School | Thomasville, Georgia | Georgia |
| Curtis Grant | Linebacker | Hermitage High School | Richmond, Virginia | Ohio State |
| James Wilder, Jr. | Linebacker | Plant High School | Tampa, Florida | Florida State |
| Stephone Anthony | Linebacker | Anson High School | Wadesboro, North Carolina | Clemson |