2005 New England Patriots season Regular season Regular season

| Week | Kickoff | Date_ | Opponent | Result_ | Record | Game_Site | NFL_com_Recap |
|---|---|---|---|---|---|---|---|
| 8 | 8:30PM EST | October 30, 2005 | Buffalo Bills | W 21–16 | 4–3 | Gillette Stadium | Recap |
| 9 | 9:00PM EST | November 7, 2005 | Indianapolis Colts | L 21–40 | 4–4 | Gillette Stadium | Recap |
| 10 | 1:00PM EST | November 13, 2005 | Miami Dolphins | W 23–16 | 5–4 | Dolphins Stadium | Recap |
| 11 | 1:00PM EST | November 20, 2005 | New Orleans Saints | W 24–17 | 6–4 | Gillette Stadium | Recap |
| 12 | 1:00PM EST | November 27, 2005 | Kansas City Chiefs | L 16–26 | 6–5 | Arrowhead Stadium | Recap |
| 13 | 4:15PM EST | December 4, 2005 | New York Jets | W 16–3 | 7–5 | Gillette Stadium | Recap |
| 14 | 1:00PM EST | December 11, 2005 | Buffalo Bills | W 35–7 | 8–5 | Ralph Wilson Stadium | Recap |