1972 San Francisco 49ers season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 17, 1972 | San Diego Chargers | W 34-3 | 59438 |
| 2 | September 24, 1972 | at Buffalo Bills | L 27-20 | 45845 |
| 3 | October 1, 1972 | at New Orleans Saints | W 37-2 | 69840 |
| 4 | October 8, 1972 | at Los Angeles Rams | L 31-7 | 77382 |
| 5 | October 15, 1972 | New York Giants | L 23-17 | 58606 |
| 6 | October 22, 1972 | New Orleans Saints | T 20-20 | 59167 |
| 7 | October 29, 1972 | at Atlanta Falcons | W 49-14 | 58850 |
| 8 | November 5, 1972 | at Green Bay Packers | L 34-24 | 47897 |
| 9 | November 12, 1972 | Baltimore Colts | W 24-21 | 61214 |