2006 Chicago Cubs season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 1 | Giants | 6–2 | Lowry (7–8) | 38582 | 55–79 |
| September 2 | Giants | 4–2 | Marshall (5–9) | 40135 | 55–80 |
| September 3 | Giants | 7–4 | Wuertz (1–1) | 40702 | 55–81 |
| September 4 | Pirates | 5–4 | Zambrano (14–6) | 37994 | 55–82 |
| September 5 | Pirates | 6–5 | Dempster (1–8) | 31494 | 55–83 |
| September 6 | Pirates | 7–2 | Grabow (4–2) | 32557 | 56–83 |
| September 7 | Pirates | 7–5 | Eyre (0–2) | 27105 | 56–84 |
| September 8 | @ Braves | 8–4 | Guzmán (0–5) | 30977 | 56–85 |
| September 9 | @ Braves | 7–3 | Miller (0–1) | 40584 | 56–86 |
| September 10 | @ Braves | 2–1 | Mateo (1–3) | 28212 | 56–87 |
| September 11 | @ Braves | 8–3 | Smoltz (12–9) | 19444 | 57–87 |
| September 12 | Dodgers | 9–8 | Hamulack (0–3) | 35618 | 58–87 |