Serena Williams Singles: 21 (17 titles, 4 runner-ups) Singles: 21 (17 titles, 4 runner-ups)

| Outcome | Year_ | Championship | Surface | Opponent | Score |
|---|---|---|---|---|---|
| Runner-up | 2008 | Wimbledon (2) | Grass | Venus Williams | 5–7, 4–6 |
| Winner | 2008 | US Open (3) | Hard | Jelena Janković | 6–4, 7–5 |
| Winner | 2009 | Australian Open (4) | Hard | Dinara Safina | 6–0, 6–3 |
| Winner | 2009 | Wimbledon (3) | Grass | Venus Williams | 7–6 (7–3) , 6–2 |
| Winner | 2010 | Australian Open (5) | Hard | Justine Henin | 6–4, 3–6, 6–2 |
| Winner | 2010 | Wimbledon (4) | Grass | Vera Zvonareva | 6–3, 6–2 |
| Runner-up | 2011 | US Open (2) | Hard | Samantha Stosur | 2–6, 3–6 |
| Winner | 2012 | Wimbledon (5) | Grass | Agnieszka Radwańska | 6–1, 5–7, 6–2 |
| Winner | 2012 | US Open (4) | Hard | Victoria Azarenka | 6–2, 2–6, 7–5 |
| Winner | 2013 | French Open (2) | Clay | Maria Sharapova | 6–4, 6–4 |
| Winner | 2013 | US Open (5) | Hard | Victoria Azarenka | 7–5, 6–7 (6–8) , 6–1 |