1981 Toronto Blue Jays season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 9 | @ Tigers | 6–2 | McLaughlin (0–1) | 51452 | 0–1 |
| April 11 | @ Tigers | 6–2 | Stieb (0–1) | 13617 | 0–2 |
| April 12 | @ Tigers | 6–2 | Bailey (0–1) | 9950 | 1–2 |
| April 13 | Yankees | 5–1 | John (1–1) | 25112 | 2–2 |
| April 15 | Yankees | 6–3 | Todd (0–1) | 16280 | 2–3 |
| April 16 | Tigers | 2–0 | Stieb (0–2) | 11058 | 2–4 |
| April 17 | Tigers | 8–5 | Leal (1–1) | 15196 | 2–5 |
| April 18 | Tigers | 4–3 | Clancy (1–1) | 16294 | 2–6 |
| April 19 | Tigers | 9–1 | Morris (1–1) | 12274 | 3–6 |
| April 20 | Brewers | 5–4 (12) | Willis (0–1) | 12298 | 3–7 |
| April 21 | Brewers | 6–2 | Stieb (0–3) | 11083 | 3–8 |
| April 22 | Brewers | 8–1 | Leal (1–2) | 11792 | 3–9 |