2008 San Diego Padres season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 12 | @ Dodgers | 11–1 | Young (1–1) | 54955 | 6–6 |
| April 13 | @ Dodgers | 1–0 | Billingsley (0–2) | 47357 | 7–6 |
| April 15 | Rockies | 6–0 | Jiménez (1–2) | 24439 | 8–6 |
| April 16 | Rockies | 10–2 | Germano (0–1) | 21730 | 8–7 |
| April 17 | Rockies | 2 – 1 (22) | Rusch (0–1) | 25984 | 8–8 |
| April 18 | @ D-backs | 9–0 | Maddux (2–1) | 26783 | 8–9 |
| April 19 | @ D-backs | 10–3 | Thatcher (0–2) | 39726 | 8–10 |
| April 20 | @ D-backs | 9–4 | Johnson (0–1) | 28090 | 9–10 |
| April 21 | @ Astros | 10–3 | Germano (0–2) | 28600 | 9–11 |
| April 22 | @ Astros | 11–7 | Bell (0–2) | 33434 | 9–12 |
| April 23 | Giants | 3–2 | Rusch (0–2) | 25506 | 9–13 |
| April 24 | Giants | 1–0 | Young (1–2) | 26789 | 9–14 |