2008 San Francisco 49ers season Regular season Regular season

| Week | Date_ | Time_PT_ | Opponent | Result_ | Record | Game_site |
|---|---|---|---|---|---|---|
| 1 | September 7, 2008 | 1:15 p.m. | Arizona Cardinals | L 13-23 | 0-1 | Candlestick Park |
| 2 | September 14, 2008 | 1:05 p.m. | at Seattle Seahawks | W 33-30 (OT) | 1-1 | Qwest Field |
| 3 | September 21, 2008 | 1:05 p.m. | Detroit Lions | W 31-13 | 2-1 | Candlestick Park |
| 4 | September 28, 2008 | 10 a.m. | at New Orleans Saints | L 17-31 | 2-2 | Louisiana Superdome |
| 5 | October 5, 2008 | 1:15 p.m. | New England Patriots | L 21-30 | 2-3 | Candlestick Park |
| 6 | October 12, 2008 | 1:15 p.m. | Philadelphia Eagles | L 26-40 | 2-4 | Candlestick Park |
| 7 | October 19, 2008 | 10 a.m. | at New York Giants | L 17-29 | 2-5 | Giants Stadium |