1981 Denver Broncos season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Game_site | Record | Attendance |
|---|---|---|---|---|---|---|
| 9 | November 2 | Minnesota Vikings | W 19–17 | Mile High Stadium | 6–3 | 74834 |
| 10 | November 8 | Cleveland Browns | W 23–20 (OT) | Mile High Stadium | 7–3 | 74859 |
| 11 | November 15 | at Tampa Bay Buccaneers | W 24–7 | Tampa Stadium | 8–3 | 64518 |
| 12 | November 22 | at Cincinnati Bengals | L 21–38 | Riverfront Stadium | 8–4 | 57207 |
| 13 | November 29 | at San Diego Chargers | L 17–34 | Jack Murphy Stadium | 8–5 | 51533 |
| 14 | December 6 | Kansas City Chiefs | W 16–13 | Mile High Stadium | 9–5 | 74744 |
| 15 | December 13 | Seattle Seahawks | W 23–13 | Mile High Stadium | 10–5 | 74527 |