List of highway route numbers in Oregon Mainline routes Mainline routes

| Number_ | South_west_end | North_east_end | Formed | Eliminated_ |
|---|---|---|---|---|
| Oregon Route 221 | OR 22 in Salem | OR 18 northeast of Dayton | 1935 |  |
| Oregon Route 222 | OR 99 in Creswell | OR 126B in Springfield | 2002 |  |
| Oregon Route 222 | OR 99EB in Salem | US 20/OR 126 west of Suttle Lake | 1935 | 1950s |
| Oregon Route 223 | US 20 near Wren | OR 22 west of Rickreall | 1935 |  |
| Oregon Route 224 | OR 99E in Milwaukie | Near Ripplebrook | 1936 |  |
| Oregon Route 225 | I-5 north of Goshen | OR 126B west of Springfield | 2002 |  |
| Oregon Route 225 | OR 99 in Sutherlin | OR 38 at Elkton | 1935 | 1960s |
| Oregon Route 226 | US 20 at Crabtree Corners | OR 22 at Mehama | 1935 |  |