1921–22 Manchester United F.C. season First Division First Division

| Date_ | Opponents | H_A | Result_F_A | Scorers | Attendance_ |
|---|---|---|---|---|---|
| 29 October 1921 | Manchester City | H | 3–1 | Spence (3) | 56000 |
| 5 November 1921 | Middlesbrough | H | 3–5 | Lochhead, Sapsford, Spence | 30000 |
| 12 November 1921 | Middlesbrough | A | 0–2 |  | 18000 |
| 19 November 1921 | Aston Villa | A | 1–3 | Spence | 30000 |
| 26 November 1921 | Aston Villa | H | 1–0 | Henderson | 33000 |
| 3 December 1921 | Bradford City | A | 1–2 | Spence | 15000 |
| 10 December 1921 | Bradford City | H | 1–1 | Henderson | 9000 |
| 17 December 1921 | Liverpool | A | 1–2 | Sapsford | 40000 |
| 24 December 1921 | Liverpool | H | 0–0 |  | 30000 |
| 26 December 1921 | Burnley | H | 0–1 |  | 15000 |
| 27 December 1921 | Burnley | A | 2–4 | Lochhead, Sapsford | 10000 |
| 31 December 1921 | Newcastle United | A | 0–3 |  | 20000 |
| 2 January 1922 | Sheffield United | A | 0–3 |  | 18000 |