1959 NCAA University Division Baseball Tournament College World Series Participants

| School | Conference | Record_conference | Head_coach | CWS_appearances | CWS_best_finish | CWS_record_ |
|---|---|---|---|---|---|---|
| Penn State | N/A | 15–4 (N/A) | Joe Bedenk | 2 , (last: 1957) | 2nd , (1957) | 5–4 |
| Western Michigan | MAC | 24–7 (8–2, 0 GB) | Charlie Maher | 3 , (last: 1958) | 2nd , (1955) | 7–6 |