2005 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 11, 2005 | Houston Texans | W 22–7 | 71781 |
| 2 | September 18, 2005 | at Tampa Bay Buccaneers | L 19–3 | 64777 |
| 3 | September 25, 2005 | Atlanta Falcons | L 24–16 | 72032 |
| 4 | October 2, 2005 | at New Orleans Saints | L 19–7 | 58688 |
| 5 | October 9, 2005 | Miami Dolphins | W 20–14 | 72160 |
| 6 | October 16, 2005 | New York Jets | W 27–17 | 72045 |
| 7 | October 23, 2005 | at Oakland Raiders | L 38–17 | 42779 |
| 8 | October 31, 2005 | at New England Patriots | L 21–16 | 68756 |
| 9 | Bye | Bye | Bye | Bye |
| 10 | November 13, 2005 | Kansas City Chiefs | W 14–3 | 72093 |