2010 French Open Singles seeds Women's singles

| Seed | Rank_ | Player | Points | Points_defending | Points_won | New_points | Status_ |
|---|---|---|---|---|---|---|---|
| 1 | 1 | Serena Williams | 8475 | 500 | 500 | 8475 | Quarterfinals lost to Samantha Stosur [7] |
| 2 | 2 | Venus Williams | 6386 | 160 | 280 | 6506 | 4th round lost to Nadia Petrova [19] |
| 3 | 3 | Caroline Wozniacki | 5630 | 160 | 500 | 5970 | Quarterfinals lost to Francesca Schiavone [17] |
| 4 | 4 | Jelena Janković | 5160 | 280 | 900 | 5780 | Semifinals lost to Samantha Stosur [7] |
| 5 | 5 | Elena Dementieva | 4830 | 160 | 900 | 5570 | Semifinals lost to Francesca Schiavone [17] |
| 6 | 6 | Svetlana Kuznetsova | 4661 | 2000 | 160 | 2821 | 3rd round lost to Maria Kirilenko [30] |
| 8 | 8 | Agnieszka Radwańska | 4190 | 280 | 100 | 4010 | 2nd round lost to Yaroslava Shvedova |