2008 Grand Prix motorcycle racing season MotoGP participants MotoGP participants

| Team | Constructor_ | Motorcycle | Tyre | Rider | Rounds |
|---|---|---|---|---|---|
| Ducati Marlboro Team | Ducati | Ducati Desmosedici GP8 | B | Casey Stoner | All |
| Ducati Marlboro Team | Ducati | Ducati Desmosedici GP8 | B | Marco Melandri | All |
| Repsol Honda Team | Honda | Honda RC212V | M B | Dani Pedrosa † | 14-18 |
| Repsol Honda Team | Honda | Honda RC212V | M | Dani Pedrosa † | 1-13 |
| Repsol Honda Team | Honda | Honda RC212V | M | Tadayuki Okada | 6 |
| Repsol Honda Team | Honda | Honda RC212V | M | Nicky Hayden | 1–11, 13–18 |
| JiR Team Scot MotoGP | Honda | Honda RC212V | M | Andrea Dovizioso | All |
| Tech 3 Yamaha | Yamaha | Yamaha YZR-M1 | M | Colin Edwards | All |
| Tech 3 Yamaha | Yamaha | Yamaha YZR-M1 | M | James Toseland | All |