1981 VFL season Round 22 Round 22

| Home_team | Home_team_score | Away_team | Away_team_score | Venue | Crowd | Date_ |
|---|---|---|---|---|---|---|
| Hawthorn | 15.20 (110) | Melbourne | 8.9 (57) | Princes Park | 7912 | 29 August 1981 |
| Collingwood | 4.9 (33) | Fitzroy | 8.11 (59) | Victoria Park | 32393 | 29 August 1981 |
| South Melbourne | 10.14 (74) | North Melbourne | 15.17 (107) | Lake Oval | 8484 | 29 August 1981 |
| St Kilda | 12.15 (87) | Footscray | 5.8 (38) | Moorabbin Oval | 11948 | 29 August 1981 |
| Richmond | 5.10 (40) | Carlton | 9.13 (67) | MCG | 64207 | 29 August 1981 |
| Geelong | 7.13 (55) | Essendon | 6.11 (47) | VFL Park | 75221 | 29 August 1981 |