2006 Boston Red Sox season Game log May

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| May 1 | Yankees | 7–3 | Small (0–1) | 36339 | 15–11 |
| May 2 | Yankees | Postponed (rain) | Postponed (rain) | Postponed (rain) | 15–11 |
| May 3 | Blue Jays | 7–6 | Papelbon (0–1) | 35881 | 15–12 |
| May 4 | Blue Jays | 7–4 | Towers (0–6) | 36396 | 16–12 |
| May 5 | Orioles | 6–3 | López (1–4) | 36515 | 17–12 |
| May 6 | Orioles | 9–3 | Bédard (4–2) | 36507 | 18–12 |
| May 7 | Orioles | 10–3 | Benson (4–3) | 36022 | 19–12 |
| May 9 | @ Yankees | 14–3 | Johnson (5–3) | 54688 | 20–12 |
| May 10 | @ Yankees | 7–3 | Schilling (5–2) | 54769 | 20–13 |
| May 11 | @ Yankees | 5–3 | Villone (0–1) | 54956 | 21–13 |
| May 12 | Rangers | 6–0 | Clement (3–3) | 36102 | 21–14 |