1980 Houston Oilers season Schedule Schedule

| Game | Date_ | Opponent | Result_ | Oilers_points | Opponents | Oilers_first_downs | Record | Attendance |
|---|---|---|---|---|---|---|---|---|
| 1 | Sept. 7 | at Pittsburgh Steelers | Loss | 17 | 31 | 16 | 0–1 | 54386 |
| 2 | Sept. 15 | at Cleveland Browns | Win | 16 | 7 | 23 | 1–1 | 80243 |
| 3 | Sept. 21 | Baltimore Colts | Win | 21 | 16 | 27 | 2–1 | 47878 |
| 4 | Sept. 28 | at Cincinnati Bengals | Win | 13 | 10 | 20 | 3–1 | 50413 |
| 5 | Oct. 5 | Seattle Seahawks | Loss | 7 | 26 | 16 | 3–2 | 46860 |
| 6 | Oct. 12 | at Kansas City Chiefs | Loss | 20 | 21 | 21 | 3–3 | 75048 |
| 7 | Oct. 19 | Tampa Bay Buccaneers | Win | 20 | 14 | 23 | 4–3 | 48167 |
| 8 | Oct. 26 | Cincinnati Bengals | Win | 23 | 3 | 17 | 5–3 | 49189 |