2008 Copa Libertadores knockout stages Round of 16 Round of 16

| Team_1 | Points | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Fluminense | 6–0 | Atlético Nacional | 2–1 | 1–0 |
| Flamengo | 3–3 ( gd ) | América | 4–2 | 0–3 |
| River Plate | 1–4 | San Lorenzo | 1–2 | 2–2 |
| Atlas | 4–1 | Lanús | 1–0 | 2–2 |
| Cruzeiro | 0–6 | Boca Juniors | 1–2 | 1–2 |
| Estudiantes | 3–3 ( gd ) | LDU Quito | 0–2 | 2–1 |
| Cúcuta Deportivo | 0–6 | Santos | 0–2 | 0–2 |