2005–06 U.S. Città di Palermo season UEFA Cup UEFA Cup

| Date_and_time | Round | Opponent | Venue | Result_ | Attendance |
|---|---|---|---|---|---|
| September 15, 2005 – 20.30 | 1st Round – 1st Leg | Anorthosis Famagusta | Home | Won 2-1 | 13047 |
| September 29, 2005 – 17.00 | 1st Round – 2nd Leg | Anorthosis Famagusta | Away | Won 4-0 | 12000 |
| October 20, 2005 – 17.00 | Group Stage – Group B | Maccabi Petah Tikva | Away | Won 2-1 | 2000 |
| November 3, 2005 – 21.00 | Group Stage – Group B | Lokomotiv Moscow | Home | Drew 0-0 | 15823 |
| November 24, 2005 – 21.15 | Group Stage – Group B | Espanyol | Away | Drew 1-1 | 22000 |
| December 15, 2005 – 20.45 | Group Stage – Group B | Brøndby | Home | Won 3-0 | 4521 |