2008 Pittsburgh Pirates season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 13 | Reds | 9–1 | Cueto (1–1) | 11201 | 6–6 |
| April 14 | @ Dodgers | 6–4 | Saito (1–1) | 37334 | 7–6 |
| April 15 | @ Dodgers | 11–2 | Morris (0–2) | 37896 | 7–7 |
| April 16 | @ Dodgers | 8–1 | Maholm (0–2) | 53629 | 7–8 |
| April 18 | @ Cubs | 3–2 | Snell (2–1) | 39118 | 7–9 |
| April 19 | @ Cubs | 13–1 | Gorzelanny (1–2) | 40298 | 7–10 |
| April 20 | @ Cubs | 13–6 | Duke (0–1) | 41405 | 7–11 |
| April 21 | Marlins | 10–4 | Morris (0–3) | 8444 | 7–12 |
| April 22 | Marlins | 3–2 | Nolasco (1–2) | 10185 | 8–12 |
| April 23 | Cardinals | 7–4 | Reyes (1–1) | 10487 | 9–12 |
| April 24 | Cardinals | 6–2 | Gorzelanny (1–3) | 9544 | 9–13 |
| April 25 | Phillies | 6–5 | Duke (0–2) | 23930 | 9–14 |