2010 Southeastern Conference football season Week One Week One

| Date_ | Time_ | Visiting_team | Home_team | Site | Broadcast | Result_ | Attendance |
|---|---|---|---|---|---|---|---|
| September 4 | 7:00pm | San Jose State | #1 Alabama | Bryant-Denny Stadium • Tuscaloosa, AL | PPV | W 48–3 | 101821 |
| September 4 | 7:00pm | Arkansas State | #22 Auburn | Jordan-Hare Stadium • Auburn, AL | FSN South | W 52–26 | 83441 |
| September 4 | 7:00pm | Tennessee Tech | #17 Arkansas | Razorback Stadium • Fayetteville, AR | PPV | W 44–3 | 69596 |
| September 4 | 7:00pm | Memphis | Mississippi State | Davis Wade Stadium • Starkville, MS | ESPNU | W 49–7 | 56032 |
| September 4 | 7:30pm | Northwestern | Vanderbilt | Vanderbilt Stadium • Nashville, TN | CSS | L 21–23 | 37210 |