2006 Boston Red Sox season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 14 | @ Orioles | 6–5 | López (9–16) | 27741 | 78–68 |
| September 15 | @ Yankees | Postponed (rain) | Postponed (rain) | Postponed (rain) | 78–68 |
| September 16 | @ Yankees | 5–2 | Wang (17–6) | 55091 | 79–68 |
| September 16 | @ Yankees | 7–5 | Breslow (0–2) | 55167 | 79–69 |
| September 17 | @ Yankees | 6–3 | Villone (3–3) | 55002 | 80–69 |
| September 17 | @ Yankees | 5–4 | Farnsworth (3–5) | 55221 | 81–69 |
| September 19 | Twins | 7–3 | Wakefield (7–10) | 36242 | 81–70 |
| September 20 | Twins | 8–2 | Hansen (2–2) | 36484 | 81–71 |
| September 21 | Twins | 6–0 | Santana (18–6) | 36434 | 82–71 |
| September 22 | @ Blue Jays | 7–1 | Lilly (14–13) | 33874 | 83–71 |
| September 23 | @ Blue Jays | 5–3 | Hansack (0–1) | 42267 | 83–72 |