1978 St. Louis Cardinals (NFL) season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 3, 1978 | at Chicago Bears | L 10-17 | 52791 |
| 2 | September 10, 1978 | New England Patriots | L 6-16 | 48233 |
| 3 | September 17, 1978 | Washington Redskins | L 10-28 | 49282 |
| 4 | September 24, 1978 | at Dallas Cowboys | L 12-21 | 62760 |
| 5 | October 1, 1978 | at Miami Dolphins | L 10-24 | 43882 |
| 6 | October 8, 1978 | Baltimore Colts | L 17-30 | 47479 |
| 7 | October 15, 1978 | Dallas Cowboys | L 21-24 | 48991 |
| 8 | October 22, 1978 | at New York Jets | L 10-23 | 49244 |
| 9 | October 29, 1978 | at Philadelphia Eagles | W 16-10 | 62989 |
| 10 | November 5, 1978 | New York Giants | W 20-10 | 48820 |