2006–07 U.S. Città di Palermo season UEFA Cup UEFA Cup

| Date_and_time | Round | Opponent | Venue | Result_ | Attendance |
|---|---|---|---|---|---|
| 14 September 2006 – 21.00 | 1st round – 1st Leg | West Ham | Away | Won 1–0 | 32222 |
| 28 September 2006 – 20.45 | 1st round – 2nd Leg | West Ham | Home | Won 3–0 | 19284 |
| 19 October 2006 – 18.15 | Group Stage | Eintracht Frankfurt | Away | Won 2–1 | 50000 |
| 2 November 2006 – 20.45 | Group Stage | Newcastle | Home | Lost 0–1 | 16091 |
| 23 November 2006 – 19.00 | Group Stage | Fenerbahçe | Away | Lost 0–3 | 39071 |
| 13 December 2006 – 20.45 | Group Stage | Celta Vigo | Home | Drew 1–1 | 10222 |