2008 Cincinnati Bengals season Regular season Regular season

| Week | Date_ | Time_ET_ | Opponent | Result_ | Record | Game_site |
|---|---|---|---|---|---|---|
| 1 | September 7, 2008 | 1:00 P.M. | at Baltimore Ravens | L 17–10 | 0–1–0 | M&T Bank Stadium |
| 2 | September 14, 2008 | 1:00 P.M. | Tennessee Titans | L 24–7 | 0–2–0 | Paul Brown Stadium |
| 3 | September 21, 2008 | 1:00 P.M. | at New York Giants | L 26–23 | 0–3–0 | Giants Stadium |
| 4 | September 28, 2008 | 1:00 P.M. | Cleveland Browns | L 20–12 | 0–4–0 | Paul Brown Stadium |
| 5 | October 5, 2008 | 4:15 P.M. | at Dallas Cowboys | L 31–22 | 0–5–0 | Texas Stadium |
| 6 | October 12, 2008 | 1:00 P.M. | at New York Jets | L 26–14 | 0–6–0 | Giants Stadium |