2006 Seattle Mariners season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 13 | Blue Jays | 10–0 | Baek (3–1) | 26225 | 69–76 |
| September 14 | @ Royals | 10–8 | Washburn (8–14) | 8839 | 69–77 |
| September 15 | @ Royals | 11–8 | Braun (0–1) | 16412 | 70–77 |
| September 16 | @ Royals | 7–4 | Piñeiro (8–12) | 12116 | 70–78 |
| September 17 | @ Royals | 10–5 | Gobble (3–6) | 9817 | 71–78 |
| September 18 | @ Rangers | 8–1 | Hernández (11–14) | 18214 | 71–79 |
| September 19 | @ Rangers | 9–7 | Wilson (2–1) | 18551 | 72–79 |
| September 20 | @ Rangers | 6–3 | Tejeda (4–4) | 26006 | 73–79 |
| September 21 | @ White Sox | 9–0 | Vázquez (11–10) | 33976 | 74–79 |
| September 22 | @ White Sox | 11–6 | Contreras (13–9) | 37557 | 75–79 |
| September 23 | @ White Sox | 11–7 | Piñeiro (8–13) | 37400 | 75–80 |