1959 NCAA University Division Baseball Tournament College World Series Participants

| School | Conference | Record_conference | Head_coach | CWS_appearances | CWS_best_finish | CWS_record_ |
|---|---|---|---|---|---|---|
| Arizona | N/A | 36–8 (N/A) | Frank Sancet | 4 , (last: 1958) | 2nd , (1956) | 7–8 |
| Clemson | ACC | 23 –6 (11–5, 0 GB) | Bill Wilhelm | 1 , (last: 1958) | 5th , (1958) | 1–2 |
| Colorado State | N/A | 24–5 (N/A) | Pete Butler | 5 , (last: 1958) | 5th , (1955) | 2–10 |
| Connecticut |  | 20–1 (N/A) | J. Orlean Christian | 1 , (last: 1957) | 5th , (1957) | 1–2 |
| Fresno State |  | 38–11 (N/A) | Pete Beiden | 0 , (last: none) | none | 0–0 |
| Oklahoma State | Big 8 | 22–4 (17–3, 0 GB) | Toby Greene | 2 , (last: 1955) | 3rd , (1955) | 5–4 |