1980–81 Aston Villa F.C. season First Division First Division

| Date_ | Opponent | Venue | Result_ | Attendance |
|---|---|---|---|---|
| 26 December 1980 | Stoke City | Villa Park | 1–0 | 34658 |
| 27 December 1980 | Nottingham Forest | City Ground | 2–2 | 33930 |
| 10 January 1981 | Liverpool | Villa Park | 2–0 | 47960 |
| 17 January 1981 | Coventry City | Highfield Road | 2–1 | 27020 |
| 31 January 1981 | Manchester City | Villa Park | 1–0 | 33682 |
| 7 February 1981 | Everton | Goodison Park | 3–1 | 31434 |
| 21 February 1981 | Crystal Palace | Villa Park | 2–1 | 27203 |
| 28 February 1981 | Wolverhampton Wanderers | Molineux | 1–0 | 34693 |
| 7 March 1981 | Sunderland | Roker Park | 2–1 | 27278 |
| 14 March 1981 | Manchester United | Villa Park | 3–3 | 42182 |
| 21 March 1981 | Tottenham Hotspur | White Hart Lane | 0–2 | 35091 |
| 23 March 1981 | Southampton | Villa Park | 2–1 | 32467 |