USA Today All-USA high school football team 2012 team First Team Defense

| Player | Position_ | School | Hometown | College |
|---|---|---|---|---|
| Montravius Adams | Defensive line | Dooly County High School | Vienna, Georgia | Auburn |
| Robert Nkemdiche | Defensive line | Grayson High School | Loganville, Georgia | Mississippi |
| Dee Liner | Defensive line | Muscle Shoals High School | Muscle Shoals, Alabama | Alabama |
| Henry Poggi | Defensive line | Gilman School | Baltimore, Maryland | Michigan |