2008 San Diego Chargers season Regular season Regular season

| Week | Date_ | Time_ | Opponent | Result_ | Game_site | NFL_Recap | Record |
|---|---|---|---|---|---|---|---|
| 7 | October 19, 2008 | 10 a.m. | at Buffalo Bills | L 14–23 | Ralph Wilson Stadium | Recap | 3–4 |
| 8 | October 26, 2008 | 10 a.m. | at New Orleans Saints | L 32–37 | Wembley Stadium * | Recap | 3–5 |
| 9 | November 2, 2008 | Bye week | Bye week | Bye week | Bye week | Bye week | Bye week |
| 10 | November 9, 2008 | 1:15 p.m. | Kansas City Chiefs | W 20–19 | Qualcomm Stadium | Recap | 4–5 |
| 11 | November 16, 2008 | 1:15 p.m. | at Pittsburgh Steelers | L 10–11 | Heinz Field | Recap | 4–6 |
| 12 | November 23, 2008 | 5:15 p.m. | Indianapolis Colts | L 20–23 | Qualcomm Stadium | Recap | 4–7 |
| 13 | November 30, 2008 | 1:05 p.m. | Atlanta Falcons | L 16–22 | Qualcomm Stadium | Recap | 4–8 |