1999 Buffalo Bills season Schedule Schedule

| Week | Date_ | Opponent | Result_ | Attendance |
|---|---|---|---|---|
| 1 | September 12, 1999 | at Indianapolis Colts | L 31–14 | 56238 |
| 2 | September 19, 1999 | New York Jets | W 17–3 | 68839 |
| 3 | September 26, 1999 | Philadelphia Eagles | W 26–0 | 70872 |
| 4 | October 4, 1999 | at Miami Dolphins | W 23–18 | 74073 |
| 5 | October 10, 1999 | Pittsburgh Steelers | W 24–21 | 71038 |
| 6 | October 17, 1999 | Oakland Raiders | L 20–14 | 71113 |
| 7 | October 24, 1999 | at Seattle Seahawks | L 26–16 | 66301 |
| 8 | October 31, 1999 | at Baltimore Ravens | W 13–10 | 68673 |
| 9 | November 7, 1999 | at Washington Redskins | W 34–17 | 78721 |
| 10 | November 14, 1999 | Miami Dolphins | W 23–3 | 72810 |