2008 Cleveland Indians season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| March 31 | White Sox | 10–8 | Dotel (0–1) | 41872 | 1–0 |
| April 2 | White Sox | 7–2 | Vázquez (0–1) | 17645 | 2–0 |
| April 3 | White Sox | 2–1 | Westbrook (0–1) | 15785 | 2–1 |
| April 4 | @ Athletics | 6–3 | Byrd (0–1) | 13916 | 2–2 |
| April 5 | @ Athletics | 6–1 | Sabathia (0–1) | 16279 | 2–3 |
| April 6 | @ Athletics | 2–1 | Blanton (0–2) | 16384 | 3–3 |
| April 7 | @ Angels | 6–4 | Borowski (0–1) | 35014 | 3–4 |
| April 8 | @ Angels | 4–3 | Speier (0–1) | 37587 | 4–4 |
| April 9 | @ Angels | 9–5 | Byrd (0–2) | 36168 | 4–5 |
| April 11 | Athletics | 9–7 | Sabathia (0–2) | 17859 | 4–6 |
| April 12 | Athletics | 7–3 | Carmona (1–1) | 19170 | 4–7 |