Serena Williams Singles: 21 (17 titles, 4 runner-ups) Singles: 21 (17 titles, 4 runner-ups)

| Outcome | Year_ | Championship | Surface | Opponent | Score |
|---|---|---|---|---|---|
| Winner | 1999 | US Open | Hard | Martina Hingis | 6–3, 7–6 (7–4) |
| Runner-up | 2001 | US Open | Hard | Venus Williams | 2–6, 4–6 |
| Winner | 2002 | French Open | Clay | Venus Williams | 7–5, 6–3 |
| Winner | 2002 | Wimbledon | Grass | Venus Williams | 7–6 (7–4) , 6–3 |
| Winner | 2002 | US Open (2) | Hard | Venus Williams | 6–4, 6–3 |
| Winner | 2003 | Australian Open | Hard | Venus Williams | 7–6 (7–4) , 3–6, 6–4 |
| Winner | 2003 | Wimbledon (2) | Grass | Venus Williams | 4–6, 6–4, 6–2 |
| Runner-up | 2004 | Wimbledon | Grass | Maria Sharapova | 1–6, 4–6 |
| Winner | 2005 | Australian Open (2) | Hard | Lindsay Davenport | 2–6, 6–3, 6–0 |
| Winner | 2007 | Australian Open (3) | Hard | Maria Sharapova | 6–1, 6–2 |