List of highway route numbers in Oregon Mainline routes Mainline routes

| Number_ | South_west_end | North_east_end | Formed | Eliminated_ |
|---|---|---|---|---|
| Oregon Route 250 | US 101 north of Port Orford | Cape Blanco State Park | 2003 |  |
| Oregon Route 251 | Port Orford Heads State Park | US 101 in Port Orford | 2003 |  |
| Oregon Route 255 | US 101 at Brookings | US 101 south of Gold Beach | 2003 |  |
| Oregon Route 260 | US 199 southwest of Grants Pass | Grants Pass | 2003 |  |
| Oregon Route 273 | I-5 south of Siskiyou Summit | OR 66 southeast of Ashland | 2003 |  |
| Oregon Route 281 | OR 35 at Mt. Hood | US 30/OR 35 in Hood River | 2002 |  |
| Oregon Route 282 | OR 281 south of Hood River | OR 35 south of Hood River | 2002 |  |
| Oregon Route 293 | US 97 north of Madras | OR 218 in Antelope | 2002 |  |