Great Lakes region Population centers Population centers

| Rank_ | Area | State_Province | CSA_CMA_2009_population | Projected_2025_population | Projected_increase_2009_2025_ |
|---|---|---|---|---|---|
| 1 | Chicago | IL-IN-WI | 9804845 | 10935100 | 1130255 |
| 2 | Toronto | ON | 5741400 | 7408000 | 1666600 |
| 3 | Detroit | MI | 5327764 | 6191000 | 863236 |
| 4 | Cleveland | OH | 2891988 | 3172000 | 280012 |
| 5 | Milwaukee | WI | 1760268 | 1913000 | 157732 |
| 6 | Ottawa – Gatineau | ON-QC | 1451415 | 1596556 | 145141 |
| 7 | Grand Rapids | MI | 1327366 | 1530000 | 202634 |
| 8 | Buffalo | NY | 1203493 | 1040400 | -163093 |
| 9 | Rochester | NY | 1149653 | 1248600 | 98947 |
| 10 | Hamilton | ON | 740200 | 954858 | 214658 |
| 11 | Toledo | OH | 672220 | 672220 | 0 |
| 12 | Lansing | MI | 523609 | 547325 | 23716 |
| 13 | Kitchener – Cambridge – Waterloo | ON | 492400 | 635196 | 142796 |
| 14 | London | ON | 492200 | 634938 | 142738 |
| 15 | Fort Wayne | IN | 414315 | 455623 | 39366 |