2008–09 Belgian First Division During the season During the season

| Team | Outgoing_manager | Manner_of_departure | Date_of_vacancy | Replaced_by | Date_of_appointment | Position_in_table |
|---|---|---|---|---|---|---|
| Mons | Philippe Saint-Jean | Resigned | 21 August 2008 | Thierry Pister (caretaker) | 21 August 2008 | 18th |
| Roeselare | Dirk Geeraerd | Sacked | 26 October 2008 | Dennis van Wijk | 29 October 2008 | 18th |
| Germinal Beerschot | Harm van Veldhoven | Resigned | 13 November 2008 | Aimé Anthuenis | 14 November 2008 | 16th |
| Mons | Thierry Pister (caretaker) | Sacked | 4 December 2008 | Christophe Dessy (caretaker) | 4 December 2008 | 15th |
| Charleroi | Thierry Siquet | Sacked | 15 December 2008 | John Collins | 15 December 2008 | 11th |
| Genk | Ronny Van Geneugden | Resigned | 5 March 2009 | Pierre Denier and Hans Visser (caretakers) | 5 March 2009 | 4th |
| Lokeren | Georges Leekens | Resigned | 31 March 2009 | Aleksandar Janković | 6 April 2009 | 7th |