1980–81 FA Cup First round proper First round proper

| Tie_no | Home_team | Score | Away_team | Date_ |
|---|---|---|---|---|
| 1 | Enfield | 3–0 | Wembley | 22 November 1980 |
| 2 | Blackpool | 4–0 | Fleetwood Town | 22 November 1980 |
| 3 | Chester | 1–2 | Barnsley | 22 November 1980 |
| 4 | Darlington | 0–2 | Bury | 22 November 1980 |
| 5 | Barnet | 2–2 | Minehead | 22 November 1980 |
| Replay | Minehead | 1–2 | Barnet | 25 November 1980 |
| 6 | Burnley | 1–0 | Scarborough | 22 November 1980 |
| 7 | Yeovil Town | 2–1 | Farnborough Town | 22 November 1980 |
| 8 | Reading | 1–2 | Fulham | 22 November 1980 |
| 9 | Walsall | 3–0 | Stafford Rangers | 22 November 1980 |
| 10 | Gillingham | 2–1 | Dagenham | 22 November 1980 |
| 11 | Northwich Victoria | 1–1 | Huddersfield Town | 22 November 1980 |
| Replay | Huddersfield Town | 6–0 | Northwich Victoria | 25 November 1980 |