USA Today All-USA high school football team 2010 team First Team Defense

| Player | Position_ | School | Hometown | College |
|---|---|---|---|---|
| Tony Steward | Linebacker | Pedro Menendez High School | St. Augustine, Florida | Clemson |
| De`Anthony Thomas | Defensive back | Crenshaw High School | Los Angeles, California | Oregon |
| Ha`Sean Clinton-Dix | Defensive back | Dr. Phillips High School | Orlando, Florida | Alabama |
| Jordan Phillips | Athlete | Circle High School | Towanda, Kansas | Oklahoma |