2010 NHL Entry Draft Round five Round five

| Pick_ | Player | Nationality | Position_ | NHL_team | Team_from | League_from |
|---|---|---|---|---|---|---|
| 135 | Justin Florek | United States | LW | Boston Bruins | Northern Michigan Wildcats | Central Collegiate Hockey Association |
| 136 | Isaac Macleod | Canada | D | San Jose Sharks (from Ottawa) 5 | Penticton Vees | British Columbia Hockey League |
| 137 | Troy Rutkowski | Canada | D | Colorado Avalanche | Portland Winterhawks | Western Hockey League |
| 138 | Louis Domingue | Canada | G | Phoenix Coyotes (from Nashville via Carolina) 6 | Quebec Ramparts | Quebec Major Junior Hockey League |
| 139 | Luke Walker | United States / Canada | RW | Colorado Avalanche (from Los Angeles) 7 | Portland Winterhawks | Western Hockey League |
| 140 | Kenneth Agostino | United States | LW | Pittsburgh Penguins | Delbarton School | United States High School-NJ |
| 141 | Petr Mrazek | Czech Republic | G | Detroit Red Wings | Ottawa 67`s | Ontario Hockey League |