2009–10 UEFA Europa League Round of 16 Round of 16

| Team_1 | Agg_ | Team_2 | _1st_leg | _2nd_leg |
|---|---|---|---|---|
| Hamburg | 6–5 | Anderlecht | 3–1 | 3–4 |
| Rubin Kazan | 2–3 | Wolfsburg | 1–1 | 1–2 ( aet ) |
| Atlético Madrid | 2–2 ( a ) | Sporting CP | 0–0 | 2–2 |
| Benfica | 3–2 | Marseille | 1–1 | 2–1 |
| Panathinaikos | 1–4 | Standard Liège | 1–3 | 0–1 |
| Lille | 1–3 | Liverpool | 1–0 | 0–3 |
| Juventus | 4–5 | Fulham | 3–1 | 1–4 |
| Valencia | 5–5 ( a ) | Werder Bremen | 1–1 | 4–4 |