2006 Seattle Mariners season Game log September

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| September 1 | @ Devil Rays | 2–1 | Sherrill (2–3) | 11196 | 63–71 |
| September 2 | @ Devil Rays | 4–3 | Howell (0–2) | 14503 | 64–71 |
| September 3 | @ Devil Rays | 7–6 | Hernández (11–12) | 14501 | 64–72 |
| September 4 | @ Tigers | 6–2 | Washburn (8–13) | 32948 | 64–73 |
| September 5 | @ Tigers | 4–3 | Miller (0–1) | 23583 | 65–73 |
| September 6 | @ Tigers | 5–4 | Zumaya (6–3) | 23066 | 66–73 |
| September 8 | Rangers | 7–2 | Millwood (14–10) | 28646 | 67–73 |
| September 9 | Rangers | 3–2 | Rheinecker (4–6) | 33454 | 68–73 |
| September 10 | Rangers | 4–2 | Huber (1–1) | 34321 | 68–74 |
| September 11 | Blue Jays | 6–2 | Woods (4–3) | 24462 | 68–75 |
| September 12 | Blue Jays | 4–2 | Marcum (2–4) | 26144 | 69–75 |