List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation List of cities in the Americas by year of foundation

| Year_ | City | State_province_dept_etc_ | Country | Notes_ |
|---|---|---|---|---|
| 1535 | Igarassu | Pernambuco | Brazil | Site of first European settlement in Brazil, the feitoria of Igarassu, in 1516. |
| 1535 | Olinda | Pernambuco | Brazil | One of the best-preserved colonial cities in Brazil. |
| 1535 | Vila Velha | Espírito Santo | Brazil |  |
| 1535 | Paria | Oruro | Bolivia |  |
| 1536 | Santiago de Cali | Valle del Cauca | Colombia |  |
| 1536 | Popayán | Cauca | Colombia |  |
| 1536 | San Pedro Sula | Cortés | Honduras |  |
| 1536 | Tupiza | Potosí | Bolivia |  |
| 1537 | Asunción |  | Paraguay | Oldest continuously inhabited European established settlement in Paraguay. |
| 1537 | Recife | Pernambuco | Brazil | Capital of the state of Pernambuco. It is the oldest city among Brazil`s current state capitals. |
| 1538 | Bogotá | Cundinamarca | Colombia |  |
| 1538 | Guayaquil | Guayas | Ecuador |  |
| 1538 | Iguape | São Paulo | Brazil |  |