2010–11 Buffalo Sabres season Game log January

| Game | January | Opponent | Score | Decision | Location_Attendance | Record |
|---|---|---|---|---|---|---|
| 38 | 1 | Boston Bruins | 7-6 (SO) | Miller | HSBC Arena/18,690 | 16-18-4 |
| 39 | 4 | @ Colorado Avalanche | 3-4 (OT) | Miller | Pepsi Center/12,548 | 16-18-5 |
| 40 | 6 | @ San Jose Sharks | 3-0 | Miller | HP Pavilion/17,562 | 17-18-5 |
| 41 | 8 | @ Phoenix Coyotes | 2-1 | Miller | Jobing.com Arena/13,905 | 18-18-5 |
| 42 | 11 | Philadelphia Flyers | 2-5 | Miller | HSBC Arena/18,155 | 18-19-5 |
| 43 | 13 | Carolina Hurricanes | 3-2 | Miller | HSBC Arena/18,276 | 19-19-5 |
| 44 | 15 | @ New York Islanders | 3-5 | Miller | Nassau Veterans Memorial Coliseum/12,223 | 19-20-5 |
| 45 | 18 | Montreal Canadiens | 4-2 | Miller | HSBC Arena/17,565 | 20-20-5 |
| 46 | 20 | @ Boston Bruins | 2-1 (OT) | Miller | TD Garden/18,225 | 21-20-5 |