2008 Houston Astros season Game log May

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| May 2 | Brewers | 7–4 | Villanueva (1–3) | 39715 | 14–16 |
| May 3 | Brewers | 6–2 | Parra (1–2) | 35002 | 15–16 |
| May 4 | Brewers | 8 – 6 (12) | Stetter (1–1) | 38301 | 16–16 |
| May 6 | Nationals | 6–5 | Ayala (1–2) | 30335 | 17–16 |
| May 7 | Nationals | 4–3 | Hanrahan (0–2) | 30432 | 18–16 |
| May 8 | Nationals | 8–3 | Backe (2–4) | 33433 | 18–17 |
| May 9 | @ Dodgers | 7–1 | Lowe (2–3) | 52658 | 19–17 |
| May 10 | @ Dodgers | 5–0 | Billingsley (2–5) | 45212 | 20–17 |
| May 11 | @ Dodgers | 8–5 | Broxton (1–1) | 40217 | 21–17 |
| May 12 | @ Giants | 7–3 | Chulk (0–1) | 30165 | 22–17 |
| May 13 | @ Giants | 4–2 | Backe (2–5) | 30858 | 22–18 |