1981 Toronto Blue Jays season Game log April

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| April 23 | @ Yankees | Postponed (rain) Not rescheduled | Postponed (rain) Not rescheduled | Postponed (rain) Not rescheduled | Postponed (rain) Not rescheduled |
| April 24 | @ Yankees | 4–2 | Bomback (1–1) | 20863 | 3–10 |
| April 25 | @ Yankees | 7–2 | May (3–1) | 17319 | 4–10 |
| April 26 | @ Yankees | 2–1 | Underwood (0–2) | 37306 | 5–10 |
| April 27 | @ Brewers | 4–3 (12) | Garvin (0–1) | 6692 | 5–11 |
| April 28 | @ Brewers | 6–2 | Caldwell (2–2) | 6433 | 6–11 |
| April 29 | @ Brewers | 5–0 (14) | Easterly (0–1) | 7320 | 7–11 |
| April 30 | @ Orioles | 4–0 | Todd (1–2) | 7726 | 7–12 |