2008 Houston Astros season Game log May

| Date_ | Opponent | Score | Loss | Attendance | Record |
|---|---|---|---|---|---|
| May 14 | @ Giants | 6–3 | Taschner (2–1) | 33070 | 23–18 |
| May 15 | @ Giants | 8–7 | Chulk (0–2) | 33771 | 24–18 |
| May 16 | @ Rangers † | 16–8 | Wright (3–1) | 32117 | 24–19 |
| May 17 | @ Rangers † | 6–2 | Oswalt (4–4) | 38534 | 24–20 |
| May 18 | @ Rangers † | 5–4 | Gabbard (1–1) | 33561 | 25–20 |
| May 19 | Cubs | 7–2 | Moehler (1–1) | 32458 | 25–21 |
| May 20 | Cubs | 4–2 | Dempster (5–2) | 33339 | 26–21 |
| May 21 | Cubs | 5–3 | Gallagher (1–1) | 33251 | 27–21 |
| May 22 | Phillies | 7–5 | Wright (3–2) | 29263 | 27–22 |
| May 23 | Phillies | 4–3 | Eaton (0–3) | 41152 | 28–22 |
| May 24 | Phillies | 4–3 | Myers (2–6) | 42660 | 29–22 |
| May 25 | Phillies | 6–15 | Nieve (0–1) | 43079 | 29–23 |