1980–81 FA Cup Second Round Proper Second Round Proper

| Tie_no | Home_team | Score | Away_team | Date_ |
|---|---|---|---|---|
| 1 | Enfield | 2–0 | Hereford United | 13 December 1980 |
| 2 | Barnet | 0–1 | Peterborough United | 13 December 1980 |
| 3 | Burnley | 1–1 | Port Vale | 13 December 1980 |
| Replay | Port Vale | 2–0 | Burnley | 16 December 1980 |
| 4 | Bury | 2–0 | Lincoln City | 13 December 1980 |
| 5 | Gillingham | 0–0 | Maidstone United | 13 December 1980 |
| Replay | Maidstone United | 0–0 | Gillingham | 16 December 1980 |
| Replay | Gillingham | 0–2 | Maidstone United | 22 December 1980 |
| 6 | Doncaster Rovers | 2–1 | Blackpool | 13 December 1980 |
| 7 | Sheffield United | 1–1 | Chesterfield | 13 December 1980 |
| Replay | Chesterfield | 1–0 | Sheffield United | 16 December 1980 |
| 8 | Tranmere Rovers | 0–3 | Huddersfield Town | 13 December 1980 |