1921–22 FA Cup Second Round Proper Second Round Proper

| Tie_no | Home_team | Score | Away_team | Date_ |
|---|---|---|---|---|
| 1 | Liverpool | 0–1 | West Bromwich Albion | 28 January 1922 |
| 2 | Preston North End | 3–1 | Newcastle United | 28 January 1922 |
| 3 | Southampton | 1–1 | Cardiff City | 28 January 1922 |
| Replay | Cardiff City | 2–0 | Southampton | 1 February 1922 |
| 4 | Leicester City | 2–0 | Fulham | 28 January 1922 |
| 5 | Nottingham Forest | 3–0 | Hull City | 28 January 1922 |
| 6 | Aston Villa | 1–0 | Luton Town | 28 January 1922 |
| 7 | Bolton Wanderers | 1–3 | Manchester City | 28 January 1922 |
| 8 | Swindon Town | 0–1 | Blackburn Rovers | 28 January 1922 |
| 9 | Tottenham Hotspur | 1–0 | Watford | 28 January 1922 |
| 10 | Barnsley | 3–1 | Oldham Athletic | 28 January 1922 |