2008 Buffalo Bills season NFL Draft NFL Draft

| Round | Pick_ | Player | Position_ | College |
|---|---|---|---|---|
| 1 | 11 | Leodis McKelvin | Cornerback | Troy |
| 2 | 41 | James Hardy | Wide Receiver | Indiana |
| 3 | 72 | Chris Ellis | Defensive End | Virginia Tech |
| 4 | 114 | Reggie Corner | Cornerback | Akron |
| 4 | 132 Supplemental | Derek Fine | Tight End | Kansas |
| 5 | 147 | Alvin Bowen | Linebacker | Iowa State |
| 6 | 179 | Xavier Omon | Running Back | NW Missouri State |
| 7 | 219 | Demetrius Bell | Offensive Tackle | Northwestern State |
| 7 | 224 | Stevie Johnson | Wide Receiver | Kentucky |
| 7 | 251 Supplemental | Kennard Cox | Cornerback | Pittsburgh |