Question: How many subunits was Alad 's Porphyria enzyme composed of in the human being ?

text: Porphyria
Cause -- Genetics
Subtypes of porphyrias depend on which enzyme is deficient .
Porphyria is a group of diseases in which substances called porphyrins build up, negatively affecting the skin or nervous system. The types that affect the nervous system are also known as acute porphyria, as symptoms are rapid in onset and last a short time. Symptoms of an attack include abdominal pain, chest pain, vomiting, confusion, constipation, fever, high blood pressure, and high heart rate. The attacks usually last for days to weeks. Complications may include paralysis, low blood sodium levels, and seizures. Attacks may be triggered by alcohol, smoking, hormonal changes, fasting, stress, or certain medications. If the skin is affected, blisters or itching may occur with sunlight exposure. Most types of porphyria are inherited from one or both of a person's parents, and are due to a mutation in one of the genes that make heme. They may be inherited in an autosomal dominant, autosomal recessive, or X-linked dominant manner. One type, porphyria cutanea tarda, may also be due to increased iron in the liver, hepatitis C, alcohol, or HIV/AIDS. The underlying mechanism results in a decrease in the amount of heme produced and a build-up of substances involved in making heme. Porphyrias may also be classified by whether the liver or the bone marrow is affected.
Porphyria type Deficient enzyme Type of porphyria Inheritance Symptoms Prevalence
X-linked dominant protoporphyria ( XLDPP ) 5-aminolevulinate ( ALA ) synthase ( ALAS ) Erythropoietic X-linked dominant Photosensitivity , cirrhosis Rare ; about 50 cases reported
Aminolevulinate dehydratase deficiency porphyria ( ALADP ) 5-aminolevulinate dehydratase ( ALAD ) Hepatic Autosomal recessive Abdominal pain , neuropathy Extremely rare ; fewer than 10 cases ever reported
Acute intermittent porphyria ( AIP ) Hydroxymethylbilane synthase ( HMBS ) formerly porphobilinogen deaminase ( PBGD ) Hepatic Autosomal dominant Periodic abdominal pain , peripheral neuropathy , psychiatric disorders , tachycardia 1 in 10,000 -20,000
Congenital erythropoietic porphyria ( CEP ) uroporphyrinogen synthase ( UROS ) Erythropoietic Autosomal recessive Severe photosensitivity with erythema , swelling and blistering . Hemolytic anemia , splenomegaly 1 in 1,000,000 or less
Porphyria cutanea tarda ( PCT ) uroporphyrinogen decarboxylase ( UROD ) Hepatic Approximately 80% sporadic , 20% Autosomal dominant Photosensitivity with vesicles and bullae 1 in 10,000
Hereditary coproporphyria ( HCP ) coproporphyrinogen oxidase ( CPOX ) Hepatic Autosomal dominant Photosensitivity , neurologic symptoms , colic 1 in 500,000
Harderoporphyria coproporphyrinogen oxidase ( CPOX ) Erythropoietic Autosomal recessive Jaundice , anemia , enlarged liver and spleen , often neonatal . Photosensitivity later Extremely rare ; fewer than 10 cases ever reported
Variegate porphyria ( VP ) protoporphyrinogen oxidase ( PPOX ) Hepatic Autosomal dominant Photosensitivity , neurologic symptoms , developmental delay 1 in 300 in South Africa 1 in 75,000 in Finland
Erythropoietic protoporphyria ( EPP ) Ferrochelatase ( FECH ) Erythropoietic Autosomal dominant Photosensitivity with skin lesions . Gallstones , mild liver dysfunction 1 in 75,000 -200,000