I 116th CONGRESS 1st Session H. R. 4519 IN THE HOUSE OF REPRESENTATIVES September 26, 2019 Mr. Engel (for himself and Mrs. Rodgers of Washington ) introduced the following bill; which was referred to the Committee on Energy and Commerce A BILL To amend the Public Health Service Act to authorize the Director of the National Institutes of Health to make awards to outstanding scientists, including physician-scientists, to support researchers focusing on pediatric research, including basic, clinical, translational, or pediatric pharmacological research, and for other purposes.

1. Short title This Act may be cited as the Pediatricians Accelerate Childhood Therapies Act of 2019 or the PACT Act of 2019 . 2. Trans-NIH Awards for Early-Career Pediatric Researchers Part G of title IV of the Public Health Service Act ( 42 U.S.C. 288 et seq.) is amended by adding at the end the following new section: 489A. Trans-NIH Awards for Early-Career Pediatric Researchers (a) In general The Director of the NIH shall make awards to outstanding scientists, including physician-scientists, to support researchers focusing on pediatric research, including basic, clinical, translational, or pediatric pharmacological research. (b) Priority research topic areas In carrying out subsection (a), the Director of NIH, in consultation with the Director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the directors of other national research institutes and national centers that participate within the Trans-NIH Pediatric Research Consortium, shall— (1) establish priority research topic areas, informed by external stakeholders including research institutions, research societies, patient organizations, and industry; and (2) consider opportunities to align such priority pediatric research topic areas with current and future priorities of the National Institutes of Health, including— (A) childhood cancer; (B) precision medicine, genetics, and genomics; (C) rare diseases and disorders, such as sickle cell disease, and other diseases and disorders with significant unmet training needs; (D) fetal, placental, and neonatal development; and (E) child and adolescent mental health. (c) Priority awards In making awards under this section, the Director of NIH shall— (1) give priority to researchers, including physician-scientists, who have a demonstrated proficiency in conducting pediatric research, but have not yet achieved research independence at the time of their application; and (2) give special consideration to researchers from populations that are historically underrepresented in pediatric medical research. (d) Requirements The Director of NIH— (1) shall require recipients of awards under this section to use such awards to support pediatric research activities, including costs associated with laboratory staff and other costs associated with the conduct of research; and (2) may allow recipients of awards under this section to use such awards for costs associated with receiving guidance and training from senior researchers as necessary to help such recipients reach a state of research independence, including conferences and other meeting participation. (e) Supplement, not supplant Awards made under this section shall be used to supplement, and not supplant, other funding for research career development awards. . 3. Trans-NIH Pediatric Consortium Title IV of the Public Health Service is amended by inserting after section 409D ( 42 U.S.C. 284h ) the following new section: 409D–1. Trans-NIH Pediatric Consortium (a) Establishment The Director of NIH shall establish and maintain a consortium to be known as the Trans-NIH Pediatric Research Consortium (in this sections referred to as the Consortium ) to coordinate pediatric research programs across the National Institutes of Health. (b) Membership —The members of the Consortium shall consist of representatives of multiple national research institutes and national centers. (c) Chair The Chair of the Consortium shall be the Director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (or the Director’s designee). (d) Duties In coordinating pediatric research programs across the National Institutes of Health, the Consortium shall— (1) establish pediatric research priorities; (2) identify gaps and opportunities for research collaborations involving multiple national research institutes and national centers; and (3) identify opportunities to develop the next generation of pediatric researchers. (e) Consultation The Consortium shall consult regularly with external experts in the field of pediatric research, including children’s hospitals, children’s research institutions, patient organizations, and other stakeholders. .