"Field-Effect Sensors for Virus Detection: From Ebola to SARS-CoV-2...." - Page 1
Forum section: electronics / general

author: cdev
author_rank: Super Contributor
timestamp: December 26, 2020, 11:23:11 pm
content: A couple of months back I posted some info on a graphene based FET biosensor for COVID-19. Wondering what its current status was I found this much more recent article about the FET biosensor technology.There are actually a number of ways to manufacture electronic sensors that are trained to recognize DNA and/r RNA including viruses with specificity, sensitivity and speed.This article is about specialized biosensor FETs and possibly some new ways to make them using plant viruses(?) (I'm just learning about this now myself)Field-Effect Sensors for Virus Detection: From Ebola to SARS-CoV-2 and Plant Viral Enhancershttps://pubmed.ncbi.nlm.nih.gov/33329662/http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7732584/(full text)Arshak Poghossian, Melanie Jablonski, Denise Molinnus, Christina Wege, Michael J Schöning.DOI: 10.3389/fpls.2020.598103The reason lab testing technologies have become investment scandals recently is that the world really needs better ways of doing rapid medical testing. Especially in resource deprived settings. Anyway, I thought this is an interesting and topical application of the FET.----------"AbstractCoronavirus disease 2019 (COVID-19) is a novel human infectious disease provoked by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, no specific vaccines or drugs against COVID-19 are available. Therefore, early diagnosis and treatment are essential in order to slow the virus spread and to contain the disease outbreak. Hence, new diagnostic tests and devices for virus detection in clinical samples that are faster, more accurate and reliable, easier and cost-efficient than existing ones are needed. Due to the small sizes, fast response time, label-free operation without the need for expensive and time-consuming labeling steps, the possibility of real-time and multiplexed measurements, robustness and portability (point-of-care and on-site testing), biosensors based on semiconductor field-effect devices (FEDs) are one of the most attractive platforms for an electrical detection of charged biomolecules and bioparticles by their intrinsic charge. In this review, recent advances and key developments in the field of label-free detection of viruses (including plant viruses) with various types of FEDs are presented. In recent years, however, certain plant viruses have also attracted additional interest for biosensor layouts: Their repetitive protein subunits arranged at nanometric spacing can be employed for coupling functional molecules. If used as adapters on sensor chip surfaces, they allow an efficient immobilization of analyte-specific recognition and detector elements such as antibodies and enzymes at highest surface densities. The display on plant viral bionanoparticles may also lead to long-time stabilization of sensor molecules upon repeated uses and has the potential to increase sensor performance substantially, compared to conventional layouts. This has been demonstrated in different proof-of-concept biosensor devices. Therefore, richly available plant viral particles, non-pathogenic for animals or humans, might gain novel importance if applied in receptor layers of FEDs. These perspectives are explained and discussed with regard to future detection strategies for COVID-19 and related viral diseases".Keywords: COVID-19; biosensor; charged biomolecules; field effect; label-free detection; plant VLP tool; plant virus nanoparticle; virus.

author: asis
author_rank: Frequent Contributor
timestamp: December 27, 2020, 01:05:00 am
content: If some substance (without brains) uses us (people) as a material for reproduction and what is the product of this creature's vital activity?So what is life?You ask this question to Elon Musk, let him include very similar topics in the Neuralink project.