excedrin extra strength caplets for headache pain relief 1 pack of 300 count excedrin excedrin extra strength caplets provide the necessary relief you need whenever pain, migraines and headaches strike. for many, relief starts just 15 minutes after you take your dose. for the past 50 years, excedrin has been a trusted leader in headache and migraine relief. with excedrin extra strength caplets, you receive quick pain relief you can trust.