maac10 - trans resveratrol 500mg supplement (micronized pharmaceutical grade 99% pure trans-resveratrol extract + bioperine for superior absorption) (2x 250mg capsules 60ct) maac10 formulas <p><strong>500mg highest grade trans-resveratrol (99% purified micronized polygonum cuspidatum root extract + 10mg bioperine). </strong></p> <p><strong>trans-resveratrol</strong> is a natural plant extract, a polyphenol that promotes general and wellness. it is renowned for its <strong>longevity</strong> and <strong>antioxidant</strong> properties.</p> <p><strong>trans-resveratrol</strong> promotes the recycling of the all-important, longevity, <strong>nad+</strong> coenzyme. it does this by up-regulating the<strong> nmnat </strong>gene, which catalyzes the conversion of nmn nicotinamide mononucleotide to nad+. <strong>trans-resveratrol</strong> also selectively up-regulates the <strong>sirtuin</strong> family of genes, commonly referred to as the "longevity genes" mimicking some benefits of caloric restriction.</p> <p>the problem with <strong>resveratrol</strong> is poor <strong>bioavailability</strong> and rapid elimination. some recent studies have demonstrated that black pepper extract (<strong>piperine</strong>) greatly improves the bioavailability of <strong>resveratrol</strong> by delaying its <strong>glucuronidation</strong>.</p> <p><strong>bioperine</strong> is a patented form of <strong>piperine</strong> that significantly enhances the <strong>bioavailability</strong> of various supplement nutrients including coq10 (31.8%), selenium (42.6%), vitamin c (52.3%), beta carotene (61.2%) as well as <strong>resveratrol</strong>l up to 1544% as shown in one 2012 study.</p>