The global prevalence of obesity has doubled between 1980 and 2014, with more than 1.9 billion adults considered as overweight and over 600 million adults considered as obese in 2014 BIBREF0 . Since the 1970s, obesity has risen 37 percent affecting 25 percent of the U.S. adults BIBREF1 . Similar upward trends of obesity have been found in youth populations, with a 60% increase in preschool aged children between 1990 and 2010 BIBREF2 . Overweight and obesity are the fifth leading risk for global deaths according to the European Association for the Study of Obesity BIBREF0 . Excess energy intake and inadequate energy expenditure both contribute to weight gain and diabetes BIBREF3 , BIBREF4 .Obesity can be reduced through modifiable lifestyle behaviors such as diet and exercise BIBREF4 . There are several comorbidities associated with being overweight or obese, such as diabetes BIBREF5 . The prevalence of diabetes in adults has risen globally from 4.7% in 1980 to 8.5% in 2014. Current projections estimate that by 2050, 29 million Americans will be diagnosed with type 2 diabetes, which is a 165% increase from the 11 million diagnosed in 2002 BIBREF6 . Studies show that there are strong relations among diabetes, diet, exercise, and obesity (DDEO) BIBREF7 , BIBREF4 , BIBREF8 , BIBREF9 ; however, the general public's perception of DDEO remains limited to survey-based studies BIBREF10 .The growth of social media has provided a research opportunity to track public behaviors, information, and opinions about common health issues. It is estimated that the number of social media users will increase from 2.34 billion in 2016 to 2.95 billion in 2020 BIBREF11 . Twitter has 316 million users worldwide BIBREF12 providing a unique opportunity to understand users' opinions with respect to the most common health issues BIBREF13 . Publicly available Twitter posts have facilitated data collection and leveraged the research at the intersection of public health and data science; thus, informing the research community of major opinions and topics of interest among the general population BIBREF14 , BIBREF15 , BIBREF16 that cannot otherwise be collected through traditional means of research (e.g., surveys, interviews, focus groups) BIBREF17 , BIBREF18 . Furthermore, analyzing Twitter data can help health organizations such as state health departments and large healthcare systems to provide health advice and track health opinions of their populations and provide effective health advice when needed BIBREF13 .Among computational methods to analyze tweets, computational linguistics is a well-known developed approach to gain insight into a population, track health issues, and discover new knowledge BIBREF19 , BIBREF20 , BIBREF21 , BIBREF22 . Twitter data has been used for a wide range of health and non-health related applications, such as stock market BIBREF23 and election analysis BIBREF24 . Some examples of Twitter data analysis for health-related topics include: flu BIBREF25 , BIBREF26 , BIBREF27 , BIBREF28 , BIBREF29 , BIBREF30 , mental health BIBREF31 , Ebola BIBREF32 , BIBREF33 , Zika BIBREF34 , medication use BIBREF35 , BIBREF36 , BIBREF37 , diabetes BIBREF38 , and weight loss and obesity BIBREF39 , BIBREF40 , BIBREF41 , BIBREF42 , BIBREF21 .The previous Twitter studies have dealt with extracting common topics of one health issue discussed by the users to better understand common themes; however, this study utilizes an innovative approach to computationally analyze unstructured health related text data exchanged via Twitter to characterize health opinions regarding four common health issues, including diabetes, diet, exercise and obesity (DDEO) on a population level. This study identifies the characteristics of the most common health opinions with respect to DDEO and discloses public perception of the relationship among diabetes, diet, exercise and obesity. These common public opinions/topics and perceptions can be used by providers and public health agencies to better understand the common opinions of their population denominators in regard to DDEO, and reflect upon those opinions accordingly.Our approach uses semantic and linguistics analyses for disclosing health characteristics of opinions in tweets containing DDEO words. The present study included three phases: data collection, topic discovery, and topic-content analysis.This phase collected tweets using Twitter's Application Programming Interfaces (API) BIBREF43 . Within the Twitter API, diabetes, diet, exercise, and obesity were selected as the related words BIBREF4 and the related health areas BIBREF19 . Twitter's APIs provides both historic and real-time data collections. The latter method randomly collects 1% of publicly available tweets. This paper used the real-time method to randomly collect 10% of publicly available English tweets using several pre-defined DDEO-related queries (Table TABREF6 ) within a specific time frame. We used the queries to collect approximately 4.5 million related tweets between 06/01/2016 and 06/30/2016. The data will be available in the first author's website. Figure FIGREF3 shows a sample of collected tweets in this research.To discover topics from the collected tweets, we used a topic modeling approach that fuzzy clusters the semantically related words such as assigning “diabetes", “cancer", and “influenza" into a topic that has an overall “disease" theme BIBREF44 , BIBREF45 . Topic modeling has a wide range of applications in health and medical domains such as predicting protein-protein relationships based on the literature knowledge BIBREF46 , discovering relevant clinical concepts and structures in patients' health records BIBREF47 , and identifying patterns of clinical events in a cohort of brain cancer patients BIBREF48 .Among topic models, Latent Dirichlet Allocation (LDA) BIBREF49 is the most popular effective model BIBREF50 , BIBREF19 as studies have shown that LDA is an effective computational linguistics model for discovering topics in a corpus BIBREF51 , BIBREF52 . LDA assumes that a corpus contains topics such that each word in each document can be assigned to the topics with different degrees of membership BIBREF53 , BIBREF54 , BIBREF55 .Twitter users can post their opinions or share information about a subject to the public. Identifying the main topics of users' tweets provides an interesting point of reference, but conceptualizing larger subtopics of millions of tweets can reveal valuable insight to users' opinions. The topic discovery component of the study approach uses LDA to find main topics, themes, and opinions in the collected tweets.We used the Mallet implementation of LDA BIBREF49 , BIBREF56 with its default settings to explore opinions in the tweets. Before identifying the opinions, two pre-processing steps were implemented: (1) using a standard list for removing stop words, that do not have semantic value for analysis (such as “the"); and, (2) finding the optimum number of topics. To determine a proper number of topics, log-likelihood estimation with 80% of tweets for training and 20% of tweets for testing was used to find the highest log-likelihood, as it is the optimum number of topics BIBREF57 . The highest log-likelihood was determined 425 topics.The topic content analysis component used an objective interpretation approach with a lexicon-based approach to analyze the content of topics. The lexicon-based approach uses dictionaries to disclose the semantic orientation of words in a topic. Linguistic Inquiry and Word Count (LIWC) is a linguistics analysis tool that reveals thoughts, feelings, personality, and motivations in a corpus BIBREF58 , BIBREF59 , BIBREF60 . LIWC has accepted rate of sensitivity, specificity, and English proficiency measures BIBREF61 . LIWC has a health related dictionary that can help to find whether a topic contains words associated with health. In this analysis, we used LIWC to find health related topics.Obesity and Diabetes showed the highest and the lowest number of tweets (51.7% and 8.0%). Diet and Exercise formed 23.7% and 16.6% of the tweets (Table TABREF6 ).Out of all 4.5 million DDEO-related tweets returned by Tweeter's API, the LDA found 425 topics. We used LIWC to filter the detected 425 topics and found 222 health-related topics. Additionally, we labeled topics based on the availability of DDEO words. For example, if a topic had “diet", we labeled it as a diet-related topic. As expected and driven by the initial Tweeter API's query, common topics were Diabetes, Diet, Exercise, and Obesity (DDEO). (Table TABREF7 ) shows that the highest and the lowest number of topics were related to exercise and diabetes (80 and 21 out of 222). Diet and Obesity had almost similar rates (58 and 63 out of 222).Each of the DDEO topics included several common subtopics including both DDEO and non-DDEO terms discovered by the LDA algorithm (Table TABREF7 ). Common subtopics for “Diabetes", in order of frequency, included type 2 diabetes, obesity, diet, exercise, blood pressure, heart attack, yoga, and Alzheimer. Common subtopics for “Diet" included obesity, exercise, weight loss [medicine], celebrities, vegetarian, diabetes, religious diet, pregnancy, and mental health. Frequent subtopics for “Exercise" included fitness, obesity, daily plan, diet, brain, diabetes, and computer games. And finally, the most common subtopics for “Obesity" included diet, exercise, children, diabetes, Alzheimer, and cancer (Table TABREF7 ). Table TABREF8 provides illustrative examples for each of the topics and subtopics.Further exploration of the subtopics revealed additional patterns of interest (Tables TABREF7 and TABREF8 ). We found 21 diabetes-related topics with 8 subtopics. While type 2 diabetes was the most frequent of the sub-topics, heart attack, Yoga, and Alzheimer are the least frequent subtopics for diabetes. Diet had a wide variety of emerging themes ranging from celebrity diet (e.g., Beyonce) to religious diet (e.g., Ramadan). Diet was detected in 63 topics with 10 subtopics; obesity, and pregnancy and mental health were the most and the least discussed obesity-related topics, respectively. Exploring the themes for Exercise subtopics revealed subjects such as computer games (e.g., Pokemon-Go) and brain exercises (e.g., memory improvement). Exercise had 7 subtopics with fitness as the most discussed subtopic and computer games as the least discussed subtopic. Finally, Obesity themes showed topics such as Alzheimer (e.g., research studies) and cancer (e.g., breast cancer). Obesity had the lowest diversity of subtopics: six with diet as the most discussed subtopic, and Alzheimer and cancer as the least discussed subtopics.Diabetes subtopics show the relation between diabetes and exercise, diet, and obesity. Subtopics of diabetes revealed that users post about the relationship between diabetes and other diseases such as heart attack (Tables TABREF7 and TABREF8 ). The subtopic Alzheimer is also shown in the obesity subtopics. This overlap between categories prompts the discussion of research and linkages among obesity, diabetes, and Alzheimer's disease. Type 2 diabetes was another subtopic expressed by users and scientifically documented in the literature.The main DDEO topics showed some level of interrelationship by appearing as subtopics of other DDEO topics. The words with italic and underline styles in Table 2 demonstrate the relation among the four DDEO areas. Our results show users' interest about posting their opinions, sharing information, and conversing about exercise & diabetes, exercise & diet, diabetes & diet, diabetes & obesity, and diet & obesity (Figure FIGREF9 ). The strongest correlation among the topics was determined to be between exercise and obesity ( INLINEFORM0 ). Other notable correlations were: diabetes and obesity ( INLINEFORM1 ), and diet and obesity ( INLINEFORM2 ).Diabetes, diet, exercise, and obesity are common public health related opinions. Analyzing individual- level opinions by automated algorithmic techniques can be a useful approach to better characterize health opinions of a population. Traditional public health polls and surveys are limited by a small sample size; however, Twitter provides a platform to capture an array of opinions and shared information a expressed in the words of the tweeter. Studies show that Twitter data can be used to discover trending topics, and that there is a strong correlation between Twitter health conversations and Centers for Disease Control and Prevention (CDC) statistics BIBREF62 .This research provides a computational content analysis approach to conduct a deep analysis using a large data set of tweets. Our framework decodes public health opinions in DDEO related tweets, which can be applied to other public health issues. Among health-related subtopics, there are a wide range of topics from diseases to personal experiences such as participating in religious activities or vegetarian diets.Diabetes subtopics showed the relationship between diabetes and exercise, diet, and obesity (Tables TABREF7 and TABREF8 ). Subtopics of diabetes revealed that users posted about the relation between diabetes and other diseases such as heart attack. The subtopic Alzheimer is also shown in the obesity subtopics. This overlap between categories prompts the discussion of research and linkages among obesity, diabetes, and Alzheimer's disease. Type 2 diabetes was another subtopic that was also expressed by users and scientifically documented in the literature. The inclusion of Yoga in posts about diabetes is interesting. While yoga would certainly be labeled as a form of fitness, when considering the post, it was insightful to see discussion on the mental health benefits that yoga offers to those living with diabetes BIBREF63 .Diet had the highest number of subtopics. For example, religious diet activities such as fasting during the month of Ramadan for Muslims incorporated two subtopics categorized under the diet topic (Tables TABREF7 and TABREF8 ). This information has implications for the type of diets that are being practiced in the religious community, but may help inform religious scholars who focus on health and psychological conditions during fasting. Other religions such as Judaism, Christianity, and Taoism have periods of fasting that were not captured in our data collection, which may have been due to lack of posts or the timeframe in which we collected data. The diet plans of celebrities were also considered influential to explaining and informing diet opinions of Twitter users BIBREF64 .Exercise themes show the Twitter users' association of exercise with “brain" benefits such as increased memory and cognitive performance (Tables TABREF7 and TABREF8 ) BIBREF65 . The topics also confirm that exercising is associated with controlling diabetes and assisting with meal planning BIBREF66 , BIBREF9 , and obesity BIBREF67 . Additionally, we found the Twitter users mentioned exercise topics about the use of computer games that assist with exercising. The recent mobile gaming phenomenon Pokeman-Go game BIBREF68 was highly associated with the exercise topic. Pokemon-Go allows users to operate in a virtual environment while simultaneously functioning in the real word. Capturing Pokemons, battling characters, and finding physical locations for meeting other users required physically activity to reach predefined locations. These themes reflect on the potential of augmented reality in increasing patients' physical activity levels BIBREF69 .Obesity had the lowest number of subtopics in our study. Three of the subtopics were related to other diseases such as diabetes (Tables TABREF7 and TABREF8 ). The scholarly literature has well documented the possible linkages between obesity and chronic diseases such as diabetes BIBREF1 as supported by the study results. The topic of children is another prominent subtopic associated with obesity. There has been an increasing number of opinions in regard to child obesity and national health campaigns that have been developed to encourage physical activity among children BIBREF70 . Alzheimer was also identified as a topic under obesity. Although considered a perplexing finding, recent studies have been conducted to identify possible correlation between obesity and Alzheimer's disease BIBREF71 , BIBREF72 , BIBREF73 . Indeed, Twitter users have expressed opinions about the study of Alzheimer's disease and the linkage between these two topics.This paper addresses a need for clinical providers, public health experts, and social scientists to utilize a large conversational dataset to collect and utilize population level opinions and information needs. Although our framework is applied to Twitter, the applications from this study can be used in patient communication devices monitored by physicians or weight management interventions with social media accounts, and support large scale population-wide initiatives to promote healthy behaviors and preventative measures for diabetes, diet, exercise, and obesity.This research has some limitations. First, our DDEO analysis does not take geographical location of the Twitter users into consideration and thus does not reveal if certain geographical differences exists. Second, we used a limited number of queries to select the initial pool of tweets, thus perhaps missing tweets that may have been relevant to DDEO but have used unusual terms referenced. Third, our analysis only included tweets generated in one month; however, as our previous work has demonstrated BIBREF42 , public opinion can change during a year. Additionally, we did not track individuals across time to detect changes in common themes discussed. Our future research plans includes introducing a dynamic framework to collect and analyze DDEO related tweets during extended time periods (multiple months) and incorporating spatial analysis of DDEO-related tweets.This study represents the first step in developing routine processes to collect, analyze, and interpret DDEO-related posts to social media around health-related topics and presents a transdisciplinary approach to analyzing public discussions around health topics. With 2.34 billion social media users in 2016, the ability to collect and synthesize social media data will continue to grow. Developing methods to make this process more streamlined and robust will allow for more rapid identification of public health trends in real time.Note: Amir Karami will handle correspondence at all stages of refereeing and publication.The authors state that they have no conflict of interest.This research was partially supported by the first author's startup research funding provided by the University of South Carolina, School of Library and Information Science. We thank Jill Chappell-Fail and Jeff Salter at the University of South Carolina College of Information and Communications for assistance with technical support.References

Q: Do they evaluate only on English data?

Q: How strong was the correlation between exercise and diabetes?
A: weak correlation with p-value of 0.08

Q: How were topics of interest about DDEO identified?
A: using topic modeling model Latent Dirichlet Allocation (LDA)