hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Brigatinib
Brigatinib, sold under the brand name Alunbrig among others, is a small-molecule targeted cancer therapy being developed by Ariad Pharmaceuticals, Inc. Brigatinib acts as an inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR), as well as several nonreceptor tyrosine kinases such as FAK, FAK2, and FER. It shows activity against ALK-positive non–small cell lung cancer, ALK-positive anaplastic large cell lymphoma (ALCL), and NF2-related schwannomatosis.

Brigatinib could overcome resistance to osimertinib conferred by the EGFR C797S mutation if it is combined with an anti-EGFR antibody such as cetuximab or panitumumab.

Drug development
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes preclinical research on microorganisms and animals, filing for regulatory status, such as via the United States Food and Drug Administration for an investigational new drug to initiate clinical trials on humans, and may include the step of obtaining regulatory approval with a new drug application to market the drug. The entire process—from concept through preclinical testing in the laboratory to clinical trial development, including Phase I–III trials—to approved vaccine or drug typically takes more than a decade.
Zagórzany, Świętokrzyskie Voivodeship
Zagórzany [zaɡuˈʐanɨ] is a village in the administrative district of Gmina Solec-Zdrój, within Busko County, Świętokrzyskie Voivodeship, in south-central Poland. It lies approximately 4 km (2 mi) south-west of Solec-Zdrój, 17 km (11 mi) south-east of Busko-Zdrój, and 62 km (39 mi) south of the regional capital Kielce.

Busko County
Busko (Polish: powiat buski) is a unit of territorial administration and local government (powiat) in Świętokrzyskie Voivodeship, south-central Poland. It came into being on January 1, 1999, as a result of the Polish local government reforms passed in 1998. Its administrative seat and only town is Busko-Zdrój, which lies 47 kilometres (29 mi) south of the regional capital Kielce.

The county covers an area of 967.39 square kilometres (373.5 sq mi). As of 2019 its total population is 67,821, out of which the population of Busko-Zdrój is 15,832 and the rural population is 51,989.
2023 AFA Liga Profesional de Fútbol
The 2023 Liga Profesional de Fútbol (officially the Torneo Binance 2023, until the 26th round, for sponsorship reasons) was the 133rd season of top-flight professional football in Argentina. The league season began on 27 January and ended on 30 July 2023.

Twenty-eight teams competed in the league: twenty-six returning from the 2022 season as well as two promoted teams from the 2022 Primera Nacional (Belgrano and Instituto). Boca Juniors were the defending champions.

River Plate won their 38th national league championship with two matches to spare after they defeated Estudiantes (LP) 3–1 on 15 July 2023.

2022 Primera Nacional
The 2022 Argentine Primera Nacional, also known as the Campeonato de Primera Nacional Torneo Malvinas Argentinas 2022, was the 38th season of the Primera Nacional, the second tier competition of Argentine football. The season began on 11 February and ended on 19 November 2022. Thirty-seven teams competed in the league, thirty-three returning from the 2021 season, two teams promoted from Torneo Federal A and two from Primera B Metropolitana.

Belgrano were the champions, clinching direct promotion as well as their first title in the competition with two matches in hand and a 3–2 victory over Brown (A) on 25 September 2022. Instituto were the other promoted team, winning the Torneo Reducido after defeating Estudiantes (BA) in the final.
Monica Iacob Ridzi
Monica Maria Iacob Ridzi (born 30 June 1977 in Petroșani) is a Romanian politician. She was the head of the youth wing of the Democratic Liberal Party, and a representative in the Chamber of Deputies of Romania since 2008. She is a former member of the Boc cabinet, and was a Member of the European Parliament during 2007–2008.

In February 2015, she received a 5-year prison sentence for abuse of office in relation to the 2009 Youth Day. On December 3, 2015, President Klaus Iohannis rejected Ridzi's pardon plea. In December 2017, she was released from prison, after spending nearly three years incarcerated.

Democratic Liberal Party (Romania)
The Democratic Liberal Party (Romanian: Partidul Democrat-Liberal, PDL) was a liberal-conservative political party in Romania. The party was formed on 15 December 2007, when the Democratic Party (PD) merged with the Liberal Democratic Party (PLD). On 17 November 2014 the PDL officially merged into the National Liberal Party (PNL), ceasing to exist. The PDL was associated with Traian Băsescu, who was previously leader of the PD and President of Romania from 2004 to 2014.
The Nature of Things
The Nature of Things (formerly, The Nature of Things with David Suzuki) is a Canadian television series of documentary programs. It debuted on CBC Television on 6 November 1960. Many of the programs document nature and the effect that humans have on it, although the program's overall scope includes documentaries on any aspect of science. The program "was one of the first mainstream programs to present scientific evidence on a number of environmental issues, including nuclear power and genetic engineering".

The series is named after an epic poem by Roman philosopher Lucretius: "De rerum natura"—On the Nature of Things.

De rerum natura
De rerum natura (Latin: [deː ˈreːrʊn naːˈtuːraː]; On the Nature of Things) is a first-century BCE didactic poem by the Roman poet and philosopher Lucretius (c. 99 – c. 55 BCE) with the goal of explaining Epicurean philosophy to a Roman audience. The poem, written in some 7,400 dactylic hexameters, is divided into six untitled books, and explores Epicurean physics through poetic language and metaphors. Namely, Lucretius explores the principles of atomism; the nature of the mind and soul; explanations of sensation and thought; the development of the world and its phenomena; and explains a variety of celestial and terrestrial phenomena. The universe described in the poem operates according to these physical principles, guided by fortuna ("chance"), and not the divine intervention of the traditional Roman deities.
André Aumerle
André Aumerle (16 February 1907 – 24 October 1990) was a French cyclist. He competed in the three events at the 1928 Summer Olympics.

Aumerle finished 8th in the individual road race event, 7th in the team road race, and 4th in the team pursuit 4,000 metres event at the 1928 Olympics.

Cycling at the 1928 Summer Olympics
The cycling competition at the 1928 Summer Olympics in Amsterdam consisted of two road cycling events and four track cycling events, all for men only.  The individual event in road cycling was a time trial over a distance of 168 km; the team competition was decided by aggregating the times of the three fastest riders from each nation.  The 50 km track event held in 1920 and 1924 was replaced by a 1 km time trial.
Georgianna Robertson
Georgianna Robertson (March 23, 1972, Port Maria, Jamaica) is a Jamaican-born model and actress. She has appeared on over  covers of Spanish, French and Italian editions of Elle and Vogue Paris. Robertson walked numerous of fashion shows, including Jean Paul Gaultier, Yves Saint Laurent, Carolina Herrera, Ralph Lauren, and the 1997 Victoria's Secret Fashion Show.

Vogue France
Vogue France (stylised in all caps) is the French edition of Vogue magazine, formerly called Vogue Paris from its inception until 2021. The magazine started publication in 1920 and has since been regarded as one of the top fashion publications.
Gautam Krishna
Gautam Krishna is an Indian Politician and former Block Development Officer (BDO) from Bihar and a Member of the Bihar Legislative Assembly. Krishna won the Mahishi Assembly constituency of Saharsa district on the RJD ticket in the 2025 Bihar Legislative Assembly election. He was the topper of Patna College in his batch and a gold medalist of Patna University.

Rashtriya Janata Dal
The Rashtriya Janata Dal (RJD, lit. 'National People's Party') is an Indian political party, mainly based in the state of Bihar. The party was founded in 1997 by Lalu Prasad Yadav.

The party's support base has traditionally been Other Backward Classes, Dalits and Muslims and it is considered a political champion of the lower castes. In 2008, RJD received the status of recognized national level party following its performance in north-eastern states. RJD was derecognised as a national party on 30 July 2010. Leading the Mahagathbandhan alliance with 35 MLAs, it is currently the official opposition in Bihar. RJD is part of Ruling Government in Jharkhand and Kerala with its allies in Mahagathbandhan (Jharkhand) and LDF respectively.
King Arthur (board wargame)
King Arthur, subtitled "The Battle of Stonehenge, 536", is a board wargame published by Simulations Publications, Inc. (SPI) in 1979 that was one of the games in the Great Medieval Battles "quadrigame" — a set of four thematically linked games that use the same set of rules. The game simulates the fictional Battle of Camlann between the forces of King Arthur and his son Mordred.

Simulations Publications, Inc.
Simulations Publications, Inc. (SPI) was an American publisher of board wargames and related magazines, particularly its flagship Strategy & Tactics, in the 1970s and early 1980s. It produced an enormous number of games and introduced innovative practices, changing the course of the wargaming hobby in its bid to take control of the hobby away from then-dominant Avalon Hill. SPI ran out of cash in early 1982 when TSR called in a loan secured by SPI's assets. TSR began selling SPI's inventory in 1982, but later acquired the company's trademarks and copyrights in 1983 and continued a form of the operation until 1987.
Michael Edwards (American composer)
Michael Edwards (1893–1962) was an American composer and musician, known for composing the 1937 hit "Once in a While". He was also a classical violinist, organist and music arranger.

Edwards's most famous composition, "Once in a While", became a number one hit for Tommy Dorsey and His Orchestra, and later for Patti Page (1957) and The Chimes (1961). The song is now considered a jazz standard. None of Edwards's other songs achieved the popularity of "Once in a While", and he has been called "a perfect example of a one-hit composer".

One-hit wonder
A one-hit wonder is any person, band, etc., that achieves mainstream popularity, often for only one piece of work, and becomes known among the general public solely for that momentary success. The term is most commonly used in regard to music performers with only one hit single that overshadows their other work. Some artists dubbed "one-hit wonders" in a particular country had achieved success in other countries. Music artists with subsequent popular albums and hit listings are not properly considered a one-hit wonder, although artists with multiple hits have sometimes been erroneously labelled as "one-hit wonders" if one particular hit has become much more well-remembered years or decades later than their other hits. One-hit wonders usually see their popularity decreasing after their hit listing, and most often never return to hit listings with other songs or albums.
Arthur Boyle
Arthur Boyle (1840/1841 – December 10, 1919) was a politician and grocer. He was elected to the House of Commons of Canada in 1887 as a Member of the Conservative Party to represent the riding of Monck. He was defeated by John Brown in the 1891 election, but was acclaimed back into office in 1892 after Brown was unseated. He then continued to represent the riding until its abolition in 1896.

In 1868, he married Annie E. Cormick. Boyle was reeve of Dunnville from 1877 to 1879 and was warden for Haldimand County from 1878 to 1879. He ran unsuccessfully for a seat in the Legislative Assembly of Ontario in the 1886 provincial election.

Arthur Boyle died at his home in Niagara Falls, Ontario on December 10, 1919.

Haldimand County
Haldimand County is a rural city-status single-tier municipality on the Niagara Peninsula in Southern Ontario, Canada, on the north shore of Lake Erie, and on the Grand River. Despite its name, it is no longer a county by definition, as all municipal services are handled by a single level of government. Municipal offices are located in Cayuga.

The county is adjacent to Norfolk County, the County of Brant, the City of Hamilton, the townships of West Lincoln and Wainfleet, and the Six Nations reserve.
Yiğit Aslan
Yiğit Aslan (born 11 March 2003) is a Turkish swimmer competing in freestyle events. He obtained a quota for the 2020 Summer Olympics.

Inspired by a poster about a swimming course in a shopping mall, he started swimming sport at the age of ten. Aslan is a member of Enka SK. He was coached by the Italian Corrado Rosso in the national team.

He won the bronze medal in the 4 × 100 m freestyle relay event at the 2019 European Youth Summer Olympic Festival held in Baku, Azerbaijan. He competed in the 400 m, 800 m, 1500 m and 4 × 200 m freestyle relay events of the 2020 European Aquatics Championships in Budapest, Hungary.

As of January 2021, he was the owner of 38 national records in various events and age categories, all set in the last five years. He is the holder of national records in the 800 m (7:51.60) and 1500 m (14:44.03) events. At the 2020 European Aquatics Championships in Budapest, Hungary, he set a new national record with 3:50.59 in the 400 m juniors (age 17–18) event.

Turkey at the 2020 Summer Olympics
Turkey competed at the 2020 Summer Olympics in Tokyo. Originally scheduled to take place from 24 July to 9 August 2020, the Games were postponed to 23 July to 8 August 2021, due to the COVID-19 pandemic. Since the nation's official debut in 1908, Turkish athletes have appeared in every edition of the Summer Olympic Games, except the 1920 Summer Olympics in Antwerp, the 1932 Summer Olympics in Los Angeles during the worldwide Great Depression, and the 1980 Summer Olympics in Moscow because of its support for the United States-led boycott.

Turkey surpassed its previous most successful Olympic medal count, which had come during its appearance at the 2016 Summer Olympics. Its 13 medals at the 2020 Games included two gold, two silvers and nine bronze medals.
Noah in Islam
Noah, also known as Nuh (Arabic: نُوْحٌ, romanized: Nūḥ), is recognized in Islam as a prophet and messenger of God. He is also believed to be the first messenger sent by God. He is one of the Ulul 'azm prophets. Noah's mission was to warn his people, who were plunged in idol worshipping. God charged Noah with the duty of preaching to his people, advising them to abandon idolatry and to worship only God, and to live good and pure lives. Although he preached the Message of God with zeal, his people refused to mend their ways, leading to building the Ark and the Deluge, the Great Flood. In Islamic tradition, it is disputed whether the Great Flood was a global or a local one. Noah's preaching and prophethood spanned 950 years according to the Quran, ahadith and tafsir.

Generations of Adam
"Generations of Adam" is a genealogical concept recorded in Genesis 5:1 in the Hebrew Bible. It is typically taken as the name of Adam's line of descent going through Seth. Another view equates the generations of Adam with material about a second line of descent starting with Cain in Genesis 4, while Genesis 5 is taken as the "generations of Noah".
Yesterday's Hero (John Paul Young song)
"Yesterday's Hero" is a pop song by John Paul Young. The song was written by George Young and Harry Vanda and was released in February 1975 as the lead single from Young's debut studio album, Hero (1975).

The song became a worldwide hit, peaking at No. 8 in Australia, No. 1 in South Africa and No. 42 in the United States.

Hero (John Paul Young album)
Hero is the debut studio album by Australian pop singer John Paul Young. The album was released in October 1975 and peaked at 9 and stayed in the charts for 20 weeks.

The album was certified gold in Australia.
Sandpiper mine
The Sandpiper mine is a Namibian planned mining development located 120 kilometres (75 mi) south-west off the coast of the harbour town of Walvis Bay. Sandpiper represents one of the largest phosphate reserves in Namibia, having estimated reserves of 1.82 billion tonnes of ore grading 19.5% P2O5. Although phosphate mining is controversial in Namibia because of its potential impact on the fishing industry, the mining license was granted in 2011.

The mine is owned by Namibian Marine Phosphate, a subsidiary of Mawarid Mining LLC which is owned by Omani billionaire Mohammed Al Barwani.

Establishment of the Sandpiper project was stopped in 2012 due to environmental concerns. In 2021 the assessment process was re-started. As of 2025 the environmental clearance certificate has not been issued. The mining license for the project is to expire in 2031.

Mohammed Al Barwani
Mohammed bin Ali bin Mohammed Al Barwani (born October 30, 1951) is an Omani billionaire businessman, the founder and chairman of MB Holding Group of companies, which operate in oil and gas exploration and production, oilfield services, engineering and mining.
Caroline Spurgeon
Caroline Frances Eleanor Spurgeon (24 October 1869, India – 24 October 1942, Tucson, Arizona) was an English literary critic. In 1913, she was appointed Hildred Carlisle Professor of English at the University of London and became head of the Department of English at Bedford College, London. She was the first woman to be awarded a chair at the University of London, and only the third in Britain (after Edith Morley and Millicent Mackenzie). She co-founded the International Federation of University Women with Virginia Gildersleeve.

Millicent Mackenzie
Millicent Hughes Mackenzie (1863 in Bristol – 10 December 1942 in Brockweir) was a British professor of education at University College of South Wales and Monmouthshire, the first female professor in Wales and the first appointed to a fully chartered university in the United Kingdom. She wrote on the philosophy of education, founded the Cardiff Suffragist branch, became the only woman candidate in Wales in the 1918 general election, and was a key initiator of Steiner-Waldorf education in the United Kingdom.
2009 NASCAR Camping World East Series
The 2009 NASCAR Camping World East Series was the 23rd season of the Camping World East Series, a touring series sanctioned by NASCAR. Matt Kobyluck entered the season as the defending drivers' champion. Ryan Truex won the championship, 34 points in front of Eddie MacDonald.

This was the last season for the East Series with the Camping World title sponsorship. Because Camping World decided to be the title sponsor for the NASCAR Truck Series starting in 2009, they did not renew their title sponsorship of NASCAR's East and West Series after their contract for that ended at the end of the 2009 season. (So, they sponsored all three series for that year only.) K&N Filters became the new title sponsor for the East and West Series starting in 2010.

K&N Engineering
K&N Engineering, Inc. (also known simply as K&N) is a manufacturer of air filters, cold air intake systems, oil filters, performance parts, and other related products.  K&N manufactures over 12,000 parts for various makes and models of cars, trucks, SUVs, motorcycles, ATVs, industrial applications and more. Founded in the United States in 1969, K&N is headquartered in Riverside, California, in a complex of 10 buildings comprising nearly 400,000 square feet. K&N also operates facilities in England, The Netherlands, and China.
Guam Army National Guard
The Guam National Guard is a federally funded military force, part of the National Guard of the United States. Guam Army National Guard (GU ARNG) is the Army National Guard of Guam which, together with the Guam Air National Guard, comprises the Guam National Guard. GU ARNG is the ground component of the Guam National Guard under control of the governor of Guam that performs missions equivalent to those of the Army National Guards of the different states of the United States, including ground defense, disaster relief, and control of civil unrest.

The Guam Army National Guard also includes residents of the Commonwealth of the Northern Mariana Islands. A proposal has been introduced by U.S. Delegate Gregorio Sablan to form a National Guard unit in the Northern Mariana Islands, and feasibility studies are in progress in response to the proposal.

Northern Mariana Islands National Guard
The Northern Mariana Islands National Guard is a proposed National Guard unit to be formed in the Commonwealth of the Northern Mariana Islands. Currently, residents of the Northern Mariana Islands may serve in the Guam National Guard.
Moritz Lampert
Moritz Horst Lampert (born 14 May 1992) is a German professional golfer who currently plays on the Challenge Tour. He played on the European Tour in 2013 and 2015 but failed to regain his card on both occasions. He won three events on the 2014 Challenge Tour, reaching a career-high of 146 in the world rankings during that year.

Eisenhower Trophy
The Eisenhower Trophy (World Men's Amateur Team Championships) is the biennial World Amateur Team Championship for men organized by the International Golf Federation. Since the tournament was first played in 1958, it is named after Dwight D. Eisenhower, the President of the United States at the time, who was a keen amateur golfer.  From 2023, the field has been restricted to 36 teams, qualified through different criteria.

The equivalent competition for women is the Espirito Santo Trophy.
201st Field Artillery Regiment
The 201st Field Artillery Regiment ("First West Virginia") is a West Virginia Army National Guard regiment. It currently perpetuates the Virginia elements of the Maryland and Virginia Rifle Regiment, which fought in the American Revolution. Organized by Colonel Morgan Morgan in Bunker Hill, West Virginia in 1735, it is one of the oldest continually-active regiments in the U.S. Army, and the oldest unit in the West Virginia Army National Guard. Units also saw action on both sides of the American Civil War, with many companies of the regiment combined to form the Union Army's 1st West Virginia Infantry.

Headquartered in Fairmont, West Virginia, the 201st Field Artillery employs the M109A6 Paladin self-propelled howitzer, and is part of the 197th Field Artillery Brigade, which is part of the New Hampshire Army National Guard.

M109 howitzer
The M109, widely known as the Paladin, is an American 155 mm turreted self-propelled howitzer, first introduced in the early 1960s to replace the M44 and M52. It has been upgraded a number of times, most recently to the M109A7. The M109 family is the most common Western indirect-fire support weapon of maneuver brigades of armored and mechanized infantry divisions. It has a crew of four: the section chief/commander, the driver, the gunner, and the ammunition handler/loader.

The British Army replaced its M109s with the AS-90. Several European armed forces have or are currently replacing older M109s with the German PzH 2000. Upgrades to the M109 were introduced by the U.S. (see variants) and by Switzerland (KAWEST). With the cancellation of the U.S. Crusader, non-line-of-sight cannon and M1299, the M109A6 ("Paladin") will likely remain the principal self-propelled howitzer for the U.S. until a replacement enters service.