hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
PH-responsive tumor-targeted drug delivery
pH-responsive tumor-targeted drug delivery is a specialized form of targeted drug delivery that utilizes nanoparticles to deliver therapeutic drugs directly to cancerous tumor tissue while minimizing its interaction with healthy tissue.  Scientists have used drug delivery as a way to modify the pharmacokinetics and targeted action of a drug by combining it with various excipients, drug carriers, and medical devices. These drug delivery systems have been created to react to the pH environment of diseased or cancerous tissues, triggering structural and chemical changes within the drug delivery system. This form of targeted drug delivery is to localize drug delivery, prolongs the drug's effect, and protect the drug from being broken down or eliminated by the body before it reaches the tumor.

Tumor microenvironment
The tumor microenvironment is a complex ecosystem surrounding a tumor, composed of cancer cells, stromal tissue (including blood vessels, immune cells, fibroblasts and signaling molecules) and the extracellular matrix. Mutual interaction between cancer cells and the different components of the tumor microenvironment support its growth and invasion in healthy tissues which correlates with tumor resistance to current treatments and poor prognosis. The tumor microenvironment is in a constant state of change because of the tumor's ability to influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can affect the growth and evolution of cancerous cells.
United States license plate designs and serial formats
In the United States, the appearance of license plates is frequently chosen to contain symbols, colors, or slogans associated with the issuing jurisdiction, which are the 50 U.S. states, the District of Columbia, the five inhabited U.S. territories, and Native American tribes, each of which independently registers motor vehicles. Regular-issue license plates for passenger vehicles typically have six or seven characters, with vanity plates having up to eight characters in a few states.

Vehicle registration plates of Tennessee
The U.S. state of Tennessee first required its residents to register their motor vehicles in 1905. Registrants provided their own license plates for display until 1915, when the state began to issue plates.

As of 2024, plates are issued by the Tennessee Department of Revenue through its Vehicle Services Division. Only rear plates have been required since 1977.
Tennessee State Route 382
State Route 382 (SR 382) is a 1.2-mile-long (1.9 km) state highway in Roane County in the eastern portion of the U.S. state of Tennessee. It serves as a connector for US 27/SR 61 and US 70 to Roane State Community College's main campus.

Special route
In road transportation in the United States, a special route is a road in a numbered highway system that diverts a specific segment of related traffic away from another road. They are featured in many highway systems; most are found in the Interstate Highway System, U.S. highway system, and several state highway systems. Each type of special route possesses generally defined characteristics and has a defined relationship with its parent route. Typically, special routes share a route number with a dominant route, often referred as the "parent" or "mainline", and are given either a descriptor which may be used either before or after the route name, such as Alternate or Business, or a letter suffix that is attached to the route number. For example, an alternate route of U.S. Route 1 may be called "Alternate U.S. Route 1", "U.S. Route 1 Alternate", or "U.S. Route 1A". Occasionally, a special route will have both a descriptor and a suffix, such as U.S. Route 1A Business.
Ronnie Faisst
Ronald Faisst (born June 22, 1977) is an American professional freestyle motocross and snow bikecross rider. Faisst is a four-time Moto X bronze medalist and an original member of the Metal Mulisha. Faisst became a born-again Christian in 2006.

Metal Mulisha
Metal Mulisha is an American lifestyle clothing brand which was created in 1997 by Larry Linkogle and Brian Deegan. Metal Mulisha Inc. products are sold at various retail stores and company owned stores. It also offers Metal Mulisha energy drinks under the same brand in a joint venture with Rockstar. About 450 people work for MMI. The Metal Mulisha Monster Jam truck debuted in 2012 and was in competitions until 2017 during which Todd Leduc won the Monster Jam World Finals Freestyle competition in 2014, and the World Finals Racing competition in 2015.
James Hamilton Stanhope
James Hamilton Stanhope (1788 – 5 March 1825) was a British Army officer who fought in the Peninsular War and at the Battle of Waterloo. He was a Member of Parliament for Buckingham, 1817–1818, Fowey, 1818–1819, and Dartmouth, 1822–1825.

Fowey (UK Parliament constituency)
Fowey was a rotten borough in Cornwall which returned two Members of Parliament to the House of Commons in the English and later British Parliament from 1571 to 1832, when it was abolished by the Great Reform Act.
Surf Taco
Surf Taco is a chain of Mexican-Californian cuisine-style restaurants located primarily in the Jersey Shore area. The food served is also described as Coastal Cuisine. It was founded by Robert Nagel, in 2001. There are presently fourteen restaurants.

Main categories of food include:  tacos, burritos, wraps, smoothies, salads, quesadillas, and side kicks (extra chips and salsa, chicken fingers, etc).

In 2009, the New York Times called the food "cross-generationally irresistible."

Surf Taco distributed bumper stickers advertising the restaurant. Because the bumper stickers were frequently posted on public property, the then Mayor of Belmar, Ken Pringle  was quoted in The Washington Times  stating that he had considered passing a law holding the distributors responsible for removing the stickers.

Quesadilla
A quesadilla (/ˌkeɪsəˈdiːjə/; Spanish: [kesaˈðiʝa] ⓘ; Spanish diminutive of quesada) is a Mexican dish made from a tortilla folded in half or two tortillas that are filled with cheese (queso), and sometimes meats, spices, and other fillings, and then cooked on a griddle or stove. Traditionally, corn tortillas are used, but the dish can also be made with flour tortillas. Quesadillas are frequently sold at Mexican restaurants all over the world.
Yarim
Yarim (Arabic: يريم) is a town in Ibb Governorate of Yemen. Located in the highlands, Yarim is approximately halfway between Sanaa, Yemen's capital, and Taizz. The ruins of Zafar, an ancient Himyarite site, are 10 kilometers southeast of the town.

Taiz
Taiz (Arabic: تَعِزّ, romanized: Taʿizz) is a city in southwestern Yemen. It is located in the Yemeni highlands, near the port city of Mocha on the Red Sea, at an elevation of about 1,400 metres (4,600 ft) above sea level. It is the capital of Taiz Governorate. As of 2023, the city has an estimated population of approximately 940,600 residents, making it the third largest city in Yemen.
1990 Back Bay, Massachusetts, train collision
The 1990 Back Bay train collision was a collision between an Amtrak passenger train, the Night Owl, and a Massachusetts Bay Transportation Authority (MBTA) Stoughton Line commuter train just outside Back Bay station in Boston, Massachusetts, United States. An investigation by the National Transportation Safety Board (NTSB) found that the Amtrak train entered a speed-restricted curve at excessive speed, causing the train to derail and crash into the MBTA commuter train on an adjacent track. Although no one was killed in the accident, 453 people were injured and Back Bay station was closed for six days. Total damage was estimated at $14 million. The accident led to new speed restrictions and safety improvements in the vicinity of Back Bay and a revamp of Amtrak's locomotive engineer training program.

National Transportation Safety Board
The National Transportation Safety Board (NTSB) is an independent U.S. government investigative agency responsible for civil transportation accident investigation. In this role, the NTSB investigates and reports on aviation accidents and incidents, certain types of highway crashes, ship and marine accidents, pipeline incidents, bridge failures, and railroad accidents. The NTSB is also in charge of investigating cases of hazardous materials releases that occur during transportation. The agency is based in Washington, D.C. It has three regional offices, located in Anchorage, Alaska; Aurora, Colorado; and Federal Way, Washington. The agency also operated a national training center at its Ashburn facility.
Praia d'El Rey European Cup
The Praia d'El Rey European Cup was an annual professional golf tournament played at Praia d'El Rey, Portugal. It was played in 1997, 1998 and 1999 between teams of men representing the European Seniors Tour and ladies representing the Ladies European Tour. There was no handicap but the men and women played off different tees.

The men won the first event 13–7 in 1997 and retained the cup in 1998 after a 10–10 tie. The ladies won the final event 11–9 in 1999. Tommy Horton and  Marie-Laure de Lorenzi were the captains on each occasion.

Ladies European Tour
The Ladies European Tour is a professional golf tour for women which was founded in 1978. Most of the players on the tour are European, with members from more than 40 countries internationally. Despite its name, the tour also has tournaments in Africa, Asia, North America and Oceania.

The organization is based at Buckinghamshire Golf Club near London in England. Like many British-based sports organisations it is a company limited by guarantee, a legal structure which enables it to focus on maximising returns to its members through prize money, rather than on making profits for investors. The tour is run by a board of directors and a Players' Council.
Cathedral of Miranda do Douro
The Cathedral of Miranda do Douro (Portuguese: Sé de Miranda do Douro, Mirandese: Sé de Miranda de l Douro) is a Roman Catholic cathedral in Miranda do Douro, Portugal. It is the co-cathedral of the Diocese of Bragança-Miranda, which has its see in the Cathedral of Braganza.

Work on the cathedral began on 24 May 1552. Confirmation of its completion was sent to Pope Paul V in 1609. In 1770 the see was moved to Braganza by Pope Clement XIV and the Cathedral of Miranda do Douro became the co-cathedral.

Since 16 June 1910, the cathedral is protected as one of the National monuments of Portugal.

Pope Clement XIV
Pope Clement XIV (Latin: Clemens XIV; Italian: Clemente XIV; 31 October 1705 – 22 September 1774), born Giovanni Vincenzo Antonio Ganganelli, was head of the Catholic Church and ruler of the Papal States from 19 May 1769 to his death in September 1774. At the time of his election, he was the only Franciscan friar in the College of Cardinals, having been a member of the Order of Friars Minor Conventual. He is the most recent pope to take the pontifical name of "Clement" upon his election.

During his pontificate, Clement decreed the suppression of the Society of Jesus.
The Answer Is Always Yes
The Answer Is Always Yes is the third studio album by Australian singer-songwriter Alex Lahey. It was released on 19 May 2023 via Liberation Music, and supported by a North American tour from May to June. It is Lahey's first record to feature external songwriters and co-producers, marking a stylistic departure from her first two albums.

At the 2023 ARIA Music Awards, the album was nominated for Best Adult Contemporary Album.

At the AIR Awards of 2024, the album was nominated for Best Independent Rock Album or EP.

AIR Awards of 2024
The 2024 AIR Awards is the eighteenth annual Australian Independent Record Labels Association Music Awards ceremony (generally known as the AIR Awards), which took place on 1 August 2024 in Adelaide. The 2024 AIR Awards introduced two new categories; the Independent Producer of the Year and the Independent Music Video of the Year. The nominees were revealed on 14 May 2024.
Thomas Fastolf
Thomas Fastolf, sometimes spelt Fastolfe (died June 1361), was an English canon lawyer and Bishop of St David's from 1352 until his death.

Probably educated at Cambridge and then overseas, he held the degree of Doctor of Laws and his first career was as a canon lawyer in Avignon, which was then the seat of the Papacy. He is credited as the first identifiable reporter of cases in the papal court known as the Rota. As Fastolf advanced in the service of the Avignon popes, he gained a series of preferments in the British Isles, concluding with the bishopric of St David's.

Diocese of St Davids
The Diocese of St Davids is a diocese of the Church in Wales, a church of the Anglican Communion. The diocese covers the historic extent of Ceredigion, Carmarthenshire and Pembrokeshire, together with a small part of western Glamorgan. The episcopal see is the Cathedral Church of St David in the City of St Davids, Pembrokeshire. The present cathedral, which was begun in 1181, stands on the site of a monastery founded in the 6th century by Saint David.

The diocese is divided into the three archdeaconries of St Davids, Carmarthen and Cardigan (additionally, Mones Farah serves as Archdeacon Missioner). The bishop's residence is Llys Esgob in Abergwili, Carmarthenshire.
Puruarán
Puruarán is an inhabited place in Mexico. It is located in the municipality of Turicato in the state of Michoacán, in the western part of the country, 250 km west of the capital Mexico City. Puruarán is situated 1,117 meters above sea level and the number of inhabitants is 7,162.

The terrain around Puruarán is somewhat mountainous. The highest point nearby is Cerro Nombre de Dios, 1,655 meters above sea level, 3.8 km west of Puruarán.The area around Puruarán is quite sparsely populated, with 45 inhabitants per square kilometer. The nearest larger community is Tacámbaro de Codallos, 16,8 km north of Puruarán. In the surroundings around Puruarán, mainly savannah forest grows.

Tacámbaro
Tacámbaro is a municipality in the western part of the Mexican state of Michoacán. Its largest city and municipal seat is Heroica Tacámbaro de Codallos.

The city is located at 19°14′00″N 102°12′00″W﻿ / ﻿19.23333°N 102.20000°W﻿ / 19.23333; -102.20000. In the 2020 census, the municipality's population was 81,105, positioning it as the 12th largest municipality in the state. The municipality has an area of 788.69 km2 (304.51 sq mi).
Something Awesome
Something Awesome is the debut solo studio album by New Zealand rapper David Dallas, released on September 19, 2009. It is his first album following his work with Frontline under the stage name Con Psy.

Production was handled by Fire & Ice, 41 and P-Money. It features guest appearances from Aaradhna, PNC, Young Sid, Devolo, Niko & Jordache.

The album won 'Best Urban/Hip Hop Album' at the 2010 New Zealand Music Awards and was shortlisted for the inaugural Taite Music Prize.

Aaradhna
Aaradhna Jayantilal Patel (born 20 December 1983), better known by the mononym Aaradhna, is a New Zealand singer, songwriter, and musical recording artist. She made her musical debut in 2004 featuring on the single "Getting Stronger" with the group Adeaze which peaked at number one on the official New Zealand Singles Chart.
Ehman
Ehman is a German surname. Notable people with the surname include:

Gerry Ehman, (1932 – 2006), Canadian ice hockey player and scout

Jerry R. Ehman, American astronomer best known for his work at SETI

Jakob Ehman, Canadian actor best known for his role as Miles in the film adaptation of The Drawer Boy.

The Drawer Boy (film)
The Drawer Boy is a Canadian drama film, which was directed by Arturo Pérez Torres and Aviva Armour-Ostroff, and released in 2017. An adaptation of Michael Healey's play The Drawer Boy, the film stars Jakob Ehman as Miles, a young actor who takes a job as a labourer on a farm owned by lifelong friends Morgan (Richard Clarkin) and Angus (Stuart Hughes), but finds that his presence has a destabilizing effect on the men's friendship.

The film premiered at the Heartland Film Festival in 2017, and had its Canadian premiere at the Canadian Film Festival in 2018. At the Canadian Film Festival, it won the award for Best Feature Film.

At the 7th Canadian Screen Awards in 2019, the film received nominations for Best Supporting Actor (Clarkin) and Best Screenplay (Pérez Torres). Clarkin won the award for Best Supporting Actor.
Daniel Coelho
Daniel Pires Coelho (born 4 November 1978) is a Brazilian politician serving as secretary of environment of Pernambuco since 2025. From 2023 to 2024, he served as secretary of tourism of Pernambuco. From 2015 to 2023, he was a member of the Chamber of Deputies. From 2011 to 2014, he was a member of the Legislative Assembly of Pernambuco. From 2005 to 2011, he was a municipal councillor of Recife. In the 2024 mayoral election, he was a candidate for mayor of Recife.

2024 Recife mayoral election
The 2024 Recife municipal election took place in the city of Recife, Brazil on 6 October 2024. Voters elected a mayor, vice mayor, and 39 councillors.

The incumbent mayor is João Campos of the PSB. Campos is the son of the former governor of Pernambuco Eduardo Campos, who died in a plane crash while running in the 2014 presidential election. Campos was previously a Federal Deputy before being elected in the second round mayor of Recife in 2020.

Campos was elected in the first round, facing scattered opposition.
HMS Sutherland (1741)
HMS Sutherland was a 50-gun fourth rate ship of the line of the Royal Navy, built at Rotherhithe according to the dimensions laid out in the 1733 proposals of the 1719 Establishment, and launched on 15 October 1741.

Sutherland participated in the Siege of Louisbourg (1758), providing shore bombardment for the forces of Brigadier-General James Wolfe.

Sutherland was sold out of the navy in 1770.

Fourth-rate
In the rating system of the Royal Navy, a fourth-rate was a ship of the line with two gun decks which mounted between 46 and 60 guns. They served in all conflicts the Royal Navy participated in during the early modern period until they were gradually phased out of active service during the French Revolutionary and Napoleonic Wars, as their usefulness was declining; though fourth-rates often remained in service on distant stations such as the East Indies. Several fourth-rates were created by razeeing larger ships of the line, and occasionally from East Indiamen such as HMS Calcutta.
Battle of Khosta
The Battle of Khosta (1840) was a major engagement in the Russo-Circassian War (1763–1864), fought between the Russian Empire and Circassian tribes near Khosta in the Western Caucasus. Despite being outnumbered, Circassian fighters ambushed a Russian force of approximately 3,000 troops, inflicting around 2,000 casualties. This victory highlighted the effectiveness of Circassian guerrilla tactics and temporarily stalled Russian expansion in the region, boosting local resistance efforts.

Khosta Microdistrict
43°30′41.48″N 39°52′5.1″E﻿ / ﻿43.5115222°N 39.868083°E﻿ / 43.5115222; 39.868083
Khosta (Russian: Хоста) is a microdistrict in Khostinsky City District in Sochi, Krasnodar Krai, Russia, primarily known as a spa and a resort on the Black Sea coast. Khosta is located in the mouth of the Khosta River, between the center of Sochi and Adler. The area is served by the Khosta railway station.
Financial instrument
A financial instrument is a monetary contract between parties. They can be created, traded, modified and settled. They can be cash (currency), evidence of an ownership, interest in an entity or a contractual right to receive or deliver in the form of currency (forex); debt (bonds, loans); equity (shares); or  derivatives (options, futures, forwards).

International Accounting Standards IAS 32 and 39 define a financial instrument as "any contract that gives rise to a financial asset of one entity and a financial liability or equity instrument of another entity".

Financial instruments may be categorized by "asset class" depending on whether they are foreign exchange-based (reflecting foreign exchange instruments and transactions), equity-based (reflecting ownership of the issuing entity) or debt-based (reflecting a loan the investor has made to the issuing entity). If the instrument is debt it can be further categorized into short-term (less than one year) or long-term.

Share (finance)
A share (sometimes someone can refer to as stock or equity) is a unit of equity ownership in the capital stock of a corporation. It can refer to units of mutual funds, limited partnerships, and real estate investment trusts. Share capital refers to all of the shares of an enterprise. The owner of shares in a company is a shareholder (or stockholder) of the corporation. A share expresses the ownership relationship between the company and the shareholder. The denominated value of a share is its face value, and the total of the face value of issued shares represent the capital of a company, which may not reflect the market value of those shares.

The income received from the ownership of shares is a dividend. There are different types of shares such as equity shares, preference shares, deferred shares, redeemable shares, bonus shares, right shares, and employee stock option plan shares.
Robert Harley (writer)
Robert Harley  best known for his work in the sketch show Smack the Pony and the sitcom Green Wing, where he also plays Charles, the CEO of East Hampton Hospital Trust. He has written (with James Henry) The Delivery Man for ITV1. He is the co-founder of independent production company Monicker Pictures.

The Delivery Man (TV series)
The Delivery Man is a British sitcom shown on ITV for one series in 2015. The series stars Darren Boyd as Matthew Bunting, a former police constable starting a new career as a midwife. From August 2015 the series starting showing on Netflix in the UK, Ireland, United States, Canada, Australia and New Zealand.
Olax
Olax is a plant genus in the family Olacaceae. It includes 52 species native to the tropics of South America, Africa, Asia, and Australia. The name derives from the  Latin, olax   (malodorous), and refers to the unpleasant scent of some of the Olax species. Olax is an Old World genus represented by several climbers, some species have leaves and fruits smelling  of garlic such as Olax subscorpioidea and Olax gambecola, seeds of the latter are used as condiments in parts of West Africa. In India Olax nana is well known as one of the first species to emerge after forest fires, the shoots growing directly from buried roots.

Hermann Otto Sleumer
Hermann Otto Sleumer (February 21, 1906 in Saarbrücken – October 1, 1993 in Oegstgeest): 1125  was a Dutch botanist of German birth. The plant genera Sleumerodendron Virot (Proteaceae) and Sleumeria Utteridge, Nagam. & Teo (Icacinaceae), are named for him.: 2497

The standard author abbreviation Sleumer is used to indicate this person as the author when citing a botanical name.
Henry Ice Rise
Henry Ice Rise is a triangular-shaped ice rise about 70 miles (110 km) long located between Korff Ice Rise and the southern portion of Berkner Island in the Ronne Ice Shelf, Antarctica. It was first visited by the United States International Geophysical Year geophysical traverse party from Ellsworth Station, 1957–58, and was named by the Advisory Committee on Antarctic Names after Captain Clifford D. Henry of the Military Sealift Command, a veteran American polar sea captain and master of USNS Private John R. Towle (T-AK-240). Henry died aboard his ship on February 16, 1975, while returning from his fourteenth voyage to Antarctica in support of the U.S. Antarctic Research Program.

USNS Private John R. Towle
USNS Private John R. Towle (T-AK-240) was a Greenville Victory-class cargo ship that served as a commercial cargo ship during the final year of World War II. Post-war she was acquired by the U.S. Army as USAT Private John R. Towle until the 1950s when she was assigned to the U.S. Navy's Military Sea Transportation Service for various duties, including runs to Antarctica's McMurdo Sound.