hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
E-52862
E-52862, also known as sigma-1 receptor antagonist (S1A, S1RA), as well as MR-309, is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki = 17.0 ± 7.0 nM, selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels. In preclinical studies, S1RA has demonstrated efficacy in relieving neuropathic pain and pain in other sensitizing conditions, associated with an improvement of the emotional negative state.

S1RA is being developed by Esteve for the treatment of neuropathic pain and the potentiation of opioid analgesia and has successfully completed Phase I clinical trials showing good safety and tolerability, and a pharmacokinetic profile compatible with once a day oral administration. Phase II clinical trials are currently underway, making S1RA the first selective sigma-1 receptor antagonist evaluated in humans for these conditions.

Sigma-2 receptor
The sigma-2 receptor (σ2R) is a sigma receptor subtype that has attracted attention due to its involvement in diseases such as neurological diseases, neurodegenerative, neuro-ophthalmic and cancer. It is currently  under investigation for its potential diagnostic and therapeutic uses.

Although the sigma-2 receptor was identified as a separate pharmacological entity from the sigma-1 receptor in 1990, the gene that codes for the receptor was identified as TMEM97 only in 2017. TMEM97 was shown to regulate the cholesterol transporter NPC1 and to be involved in cholesterol homeostasis. The sigma-2 receptor is a four-pass transmembrane protein located in the endoplasmic reticulum. It has been found to play a role in both hormone signaling and calcium signaling, in neuronal signaling, in cell proliferation and death, and in binding of antipsychotics.
John Skipp
John Skipp (born May 20, 1957) is a splatterpunk horror and fantasy author and anthology editor, as well as a songwriter, screenwriter, film director, and film producer. He collaborated with Craig Spector on multiple novels, and has also collaborated with Marc Levinthal and Cody Goodfellow. He worked as editor-in-chief of both Fungasm Press and Ravenous Shadows.

Skipp has also been a past contributor to liner notes for cult film distributors Grindhouse Releasing/Box Office Spectaculars on the North American Blu-ray/DVD release of An American Hippie in Israel.

An American Hippie in Israel
An American Hippie in Israel, also known as Trey (from Hebrew הטרמפיסט, "The Hitch-hiker"), is a 1972 Israeli metaphorical counter-culture film written and directed by Amos Sefer, and starring Asher Tzarfati.

Many have cited this film as one of the worst films ever made. Once thought lost, it was rediscovered decades later by the cult film enthusiasts at Grindhouse Releasing who have digitally restored the film and presented it in Blu-ray and DVD.
Preah Roka Wildlife Sanctuary
Preah Roka Wildlife Sanctuary is a 90.361 km2 (34.889 sq mi) protected area in Preah Vihear Province of Cambodia. There are 41 communities in the protected areas within Preah Vihear province.  The stated purpose of its creation in 2016 was to:

Ensure protection of wildlife habitat and ecology system and satisfy condition for particular species of flora and fauna and biodiversity

Deliver natural products and services for sustainable use

Promote local communities and public-based national resource management and biodiversity protection within the area.

The area is threatened by illegal logging. The area is used by the Kuy ethnic minority for resin collection and other non-timber forest products, and members of the Prey Preah Roka Forest Community Network work together with government rangers from the Ministry of Environment, supported by the Wildlife Conservation Society to protected the site.

Preah Vihear province
Preah Vihear (Khmer: ព្រះវិហារ, UNGEGN: Preăh Vĭhar, ALA-LC: Braḥ Vihār [preah ʋihiə]; lit. 'sacred sanctuary') is a province (khaet) of Cambodia. It borders the provinces of Oddar Meanchey and Siem Reap to the west, Kampong Thom to the south and Stung Treng to the east. Its northern boundary forms part of Cambodia's international border with Thailand and Laos. Its capital is Preah Vihear.
2018 European Masters
The 2018 European Masters (officially the 2018 D88.com European Masters) was a professional ranking snooker tournament, that took place from 1 to 7 October 2018 in Lommel, Belgium. It was the fifth ranking event of the 2018/2019 season.

Qualifying took place on 17 and 18 August 2018 in Preston, England.

Judd Trump was the defending champion after winning the previous two events, but he lost 2–4 to Tian Pengfei in the second round.

Jimmy Robertson reached his first ever ranking event semi-final, which he converted into his first professional ranking event title, beating Joe Perry 9–6 in the final.

2018–19 snooker season
The 2018–19 snooker season was a series of professional snooker tournaments played between 10 May 2018 and 23 June 2019. The season was made up of ranking tournaments, non-ranking tournaments and variant tournaments. In total, 54 events were competed in the 2018–19 season, beginning with the pro–am 2018 Vienna Open, and ending with the 2019 World Snooker Championship.

To be eligible to play in most tournaments, players had to have qualified to play on the World Snooker Tour, however, some wildcard former professional, and amateur players were eligible in certain competitions. The season also saw four events strictly for over 40s, as a part of the World Seniors Tour.

Ronnie O'Sullivan, Neil Robertson and Judd Trump each won three ranking events with Mark Allen, Stuart Bingham and Kyren Wilson each winning twice. Robertson reached six ranking event finals during the season.
Oruru River
The Oruru River is a river of the Northland Region of New Zealand's North Island. It flows north from its sources south of Mangonui to reach the Taipa River 5 kilometres (3 mi) from Taipa-Mangonui.

The New Zealand Ministry for Culture and Heritage gives a translation of "place of the morepork" for Ōruru.

Mangōnui
Mangōnui is a settlement on the west side of Mangōnui Harbour in Northland, New Zealand. State Highway 10 runs through it. It is the easternmost of the Taipa-Mangonui string of settlements, separated from Coopers Beach to the northwest by Mill Bay Road.
Fansub
A fansub (short for fan-subtitled) is a version of a foreign film or foreign television program, typically anime or dorama which has been translated by fans (as opposed to an officially licensed translation done by paid professionals) and subtitled into a language usually other than that of the original.

IRC
IRC (Internet Relay Chat) is a text-based chat system for instant messaging. IRC is designed for group communication in discussion forums, called channels, but also allows one-on-one communication via private messages as well as chat and data transfer, including file sharing.

Internet Relay Chat is implemented as an application layer protocol to facilitate communication in the form of text. The chat process works on a client–server networking model. Users connect, using a client—which may be a web app, a standalone desktop program, or embedded into part of a larger program—to an IRC server, which may be part of a larger IRC network. Examples of ways used to connect include the programs Mibbit, KiwiIRC, and mIRC.

IRC usage has been declining steadily since 2003, losing 60 percent of its users by 2012. In April 2011, the top 100 IRC networks served more than 200,000 users at a time.
Prospect Park Books
Prospect Park Books was a Los Angeles–based independent publisher. Its titles are distributed by Consortium Book Sales & Distribution, a member of the Ingram Content Group. It is a member of the American Association of Publishers, Publishers Association of the West, the International Association of Culinary Professionals, and the Council of Literary Magazines and Presses. In January 2021, the company was acquired by Turner Publishing Company.

International Association of Culinary Professionals
The International Association of Culinary Professionals (IACP) is a United States–based not-for-profit professional association whose members work in culinary education, communication, or the preparation of food and beverage. It was started in 1978 with help from American cooking personality Julia Child, and offers an award in her name.
John Sweeny (bishop)
John Sweeny (May 6, 1821 – March 25, 1901) was an Irish born, Canadian Roman Catholic priest and Bishop of Saint John in New Brunswick from 1859 to 1901.

John Sweeny was born in Clones, County Monaghan, Ireland in 1821, the son of James Sweeny and Mary McGuire. He was ordained a priest, for Fredericton (St. John), New Brunswick in 1844.

Bishop Sweeny was a leading figure in opposition to the Common Schools Act of 1871 enacted by the 22nd New Brunswick Legislative Assembly. He founded the Irish Catholic community of Johnville, New Brunswick.

22nd New Brunswick Legislature
The 22nd New Brunswick Legislative Assembly represented New Brunswick between February 16, 1871, and May 15, 1874.

Lemuel Allan Wilmot served as Lieutenant-Governor of New Brunswick until  November 1873, when he was replaced by Samuel Leonard Tilley.

E.A. Vail was chosen as speaker.

The Liberal-Conservatives led by George E. King formed the government. George L. Hathaway took over the leadership of the party in February 1871. George E. King became leader again in 1872 after Hathaway's death.

In May 1871, the Common Schools Act was passed; it came into effect the following year. This legislation implemented a system of publicly funded schools. However, it excluded denominational schools; religious instruction in schools operated under the system was banned. The act offended Roman Catholics and Acadians in the province.
Mickaël Forest
Mickaël Forest (born 9 August 1975 in Chambéry, France) is a French rugby union footballer. Forest plays scrum-half for CS Bourgoin-Jallieu in France's Top 14 championship. His professional career started with CA Brive in 1999. He played with them for two years that included ten Challenge Cup matches. After Brive were relegated to Pro D2 for the 2001/2002 season Forest moved to Bourgoin. With Bourgoin Forrest played in the final of the 2003 Challenge Yves du Manoir (which was lost), and has played in 18 Heineken Cup matches. He was selected for France in their 2007 Tour to New Zealand. He made his Test debut against the All Blacks on 2 June 2007 when he came on as a substitute in the 74th minute. He made his second appearance the following week, this time coming on in the 67th minute.

Pro D2
The Pro D2 is the second tier of rugby union club competition division in France. It is operated by Ligue Nationale de Rugby (LNR) which also runs the division directly above, the first division Top 14. Pro D2 was introduced in 2000. It is the world's best-supported second-tier rugby union league.
Thomas Matthews (table tennis)
Thomas "Tom" Matthews (born 19 August 1992) is a British Paralympic table tennis player. At the 2020 Summer Paralympics, he won a bronze medal in the Men's individual class 1 event. Matthews is also a European champion and a World bronze medalist.

In 2009, Matthews was a very keen mountain biker, he went out for a bike ride with his uncle and a friend. Matthews went over the handle bars and broke his neck after going down a mountain too fast. While in rehabilitation in Rookwood Hospital, he was encouraged to try table tennis by Welsh para table tennis Paralympic medalist James Munkley when Munkley was visiting hospital wards in Wales and then Matthews joined the Welsh table tennis team in 2013 and competed internationally a year later.

Table tennis at the 2020 Summer Paralympics – Men's individual – Class 1
The Men's individual table tennis – Class 1 tournament at the 2020 Summer Paralympics in Tokyo took place between 25 and 30 August 2021 at Tokyo Metropolitan Gymnasium. Classes 1–5 were for athletes with a physical impairment that affected their legs, and who competed in a sitting position. The lower the number, the greater the impact the impairment aws on an athlete's ability to compete.

In the preliminary stage, athletes competed in four groups of three. Winners and runners-up of each group qualified for the knock-out stage, with the best two group winners receiving a bye to the quarter-finals and the other 12 teams playing from the round of 16. In this edition of the Games, no bronze medal match was held. Losers of each semifinal were automatically awarded a bronze medal.
Petro Lytvyn
Petro Mykhailovych Lytvyn (Ukrainian: Петро Михайлович Литвин; born 12 June 1967) is a Ukrainian commander and lieutenant general. He served as the commander of the 8th Army Corps from 2012 to 2015. He is the youngest brother of the Lytvyn family.

8th Army Corps (Ukraine)
The 8th Army Corps (Ukrainian: 8-й армійський корпус, romanized: 8-y armiys'kyi korpus) was one of three army corps of the Ukrainian Ground Forces. The Corps was headquartered in Zhytomyr, Ukraine. In 2015 all army corps were dissolved, and their units were transferred under jurisdiction of the operation command.

On 1 December 1993, after the dissolution of the Soviet Union, the 8th Army Corps was formed by the redesignation of the 8th Tank Army. The 23rd Tank Division at Ovruch became the 6065th Base for Storage of Weapons and Equipment, and the 117th Training Tank Division later became the 119th District Training Centre. The 30th Tank Division became a Ukrainian mechanised brigade.

In March 2015, the 8th Army Corps was disbanded and its subordinate units transferred to other commands.
Joe Harris (pitcher)
Joseph White Harris (February 1, 1882 – April 12, 1966) was an American pitcher in Major League Baseball who played from 1905 through 1907 for the Boston Americans. Listed at 6 ft 1 in (1.85 m), 198 lb., Harris batted and threw right-handed. He was born in Melrose, Massachusetts.

In a three-season career, Harris posted a 3–30 record with a 3.35 ERA in 45 appearances, including 32 starts, 26 complete games, one shutout, 12 games finished, two saves, 137 strikeouts, 88 walks, and 317.0 innings of work.

On September 1, 1906, Harris earned the distinction of pitching the longest game in Red Sox (Americans) history. The game lasted 24 innings, with the Red Sox eventually losing 4-1 to the Philadelphia Athletics.

Harris died in his home of Melrose, Massachusetts, at age 84 and is buried in Wyoming Cemetery there.

Games pitched
In baseball statistics, games pitched (denoted by Games G in tables of only pitching statistics) is the number of games in which a player appears as a pitcher. The statistic is also referred to as appearances, especially to refer to the number of games a relief pitcher has pitched in.

Normally, a pitcher must face at least one batter (or three batters in some relief situations), but exceptions are made in the case of injury. A notable example was Larry Yount, who suffered an injury while throwing warmup pitches after being summoned as a reliever in a Major League Baseball (MLB) game on September 15, 1971. He did not face a batter, but was credited with an appearance because he had been announced as a substitute. Yount never appeared in (or actually played in) any other MLB game.
Glacial till plains (Ohio)
The Glacial till plains are a till plain landform in Northern Ohio, located near the shore of Lake Erie and produced by the retreat of the Wisconsin glaciation. Since glacial till is highly fertile soil, agriculture on the glacial till plains is very productive.

The region has gently rolling moraine hills left over from the retreating glaciers, as well as small sandy ridges, which were formed as coastal dunes during periods in which Lake Erie was higher than it is today (14,000-12,000 years ago).

Till
Till, or glacial till, is unsorted glacial sediment.

Till is derived from the erosion and entrainment of material by the moving ice of a glacier. It is deposited some distance down-ice to form terminal, lateral, medial and ground moraines.

Till is classified into primary deposits, laid down directly by glaciers, and secondary deposits, reworked by fluvial transport and other processes.
The Kings of the Time
The Kings of the Time (Estonian: Aja meistrid) is a 2008 Estonian documentary and animated film directed by Mait Laas.

The film is dedicated to Estonian pioneers of animated film: Elbert Tuganov and Heino Pars.

Awards:

2008: Eesti Kultuurkapitali Audiovisuaalse kunsti sihtkapitali preemia, best documentary film

2008: Asolo Art Film festival (Italy), Premio Asolo for the Best Artist's Biography Film

2012: Tampere Film Festival, Estonia Film 100 Years, participation

Heino Pars
Heino Pars (13 October 1925 Mustla, Viljandi County – 8 October 2014 Tallinn) was an Estonian animated film director. With Elbert Tuganov, he is the founder of Estonian puppetry animation.

In 2001 he was awarded with Order of the White Star, V class.
Brendan Haami
Brendan Derek Te Oranga Haami (born 4 December 1974) is a New Zealand former professional rugby union player.

Born in Stratford, Taranaki, Haami was a diminutive half-back and is known by the nickname "Knackers".

Haami, NZ Maori representative, played 93 matches for Taranaki, debuting in 1997. He appeared for New Zealand in the 1999–2000 World Sevens Series. A Hurricanes player, Haami made most of his Super 12 appearances from 2001 to 2003, while an understudy to Jason Spice. He had a stint in England at Rotherham in 2004–05 and played briefly with Wellington on his return to New Zealand, as cover for Piri Weepu, before finishing his career back at Taranaki.

1999–2000 World Sevens Series
The 1999–2000 World Sevens Series was the first season of the global circuit for men's national rugby sevens teams, organised by the International Rugby Board (now known as World Rugby). The series ran from December 1999 to May 2000 and incorporated ten tournaments spread over five continents. New Zealand was the series champion, winning five of the tournament events. Fiji finished as runner-up, eight points behind despite winning the remaining five tournaments. The leading try-scorer for the  inaugural season was Fiji's Vilimoni Delasau, who notched 83 tries over the series.
Concepts, Techniques, and Models of Computer Programming
Concepts, Techniques, and Models of Computer Programming is a textbook published in 2004 about general computer programming concepts from MIT Press written by Université catholique de Louvain professor Peter Van Roy and Royal Institute of Technology, Sweden professor Seif Haridi.

Using a carefully selected progression of subsets of the Oz programming language, the book explains the most important programming concepts, techniques, and models (paradigms).

Translations of this book have been published in French (by Dunod Éditeur, 2007), Japanese (by Shoeisha, 2007) and Polish (by Helion, 2005).

Helion (publisher)
Helion SA is a Polish publisher founded in 1991. It has published over 1,800 IT books, but also publishes business books under the Onepress imprint and psychology books as Sensus.

Further brands include Septem, Editio and Dla bystrzaków (For dummies)
Sara Myers
Sara J. Myers is a professor emerita at Columbia Theological Seminary and former president of the American Theological Library Association. She has been the Director of numerous libraries, as well as taught at a number of universities across the country.

American Theological Library Association
The American Theological Library Association (Atla) is a nonprofit, 501(c)(3), professional association, headquartered in Chicago, Illinois, United States. Atla's member libraries and librarians provide resources for scholarly research to tens of thousands of students, faculty, staff, and administrators. The association supports the membership with services and products, including an annual conference, members-only publications and discounts, and professional development opportunities.
Juan de Lebu
Juan de Lebú was a Moluche cacique or Ulmen of the Lebu region, captured by the Spanish sometime before 1568.  He was sent to Peru and the Spaniards had baptized him with the name of Juan. He returned in 1568, with the new Governor Melchor Bravo de Saravia.  When he had the chance he escaped and returned to his people to help them in the war against the Spanish Empire.  Because he had become familiar with European tactics like Paineñamcu (Alonso Diaz), they became close collaborators in the war.

During Governor Rodrigo de Quiroga's first campaign in 1578, there was a raid that attempted to burn down the Spanish winter camp at Arauco. Juan de Lebú and seven other lonkos were captured in a retaliatory raid against the perpetrators by the Spanish under Rodrigo the nephew of Quiroga.  To punish them as an example the seven lonkos were hanged from trees while Juan de Lebú suffered the same punishment as Caupolican, impalement.

Impalement
Impalement, as a method of torture and execution, is the penetration of a human by an object such as a stake, pole, spear, or hook, often by the complete or partial perforation of the torso. It was particularly used in response to "crimes against the state" and is regarded across a number of cultures as a very harsh form of capital punishment and recorded in myth and art. Impalement was also used during times of war to suppress rebellions, punish traitors or collaborators, and punish breaches of military discipline.

Offences where impalement was occasionally employed included contempt for the state's responsibility for safe roads and trade routes by committing highway robbery or grave robbery, violating state policies or monopolies, or subverting standards for trade. Offenders have also been impaled for a variety of cultural, sexual, and religious reasons.

References to impalement in Babylonia and the Neo-Assyrian Empire are found as early as the 18th century BC.
Chicago Limited (DLW train)
The Chicago Limited was a train running from Hoboken, New Jersey to Chicago, Illinois run by the Lackawanna Railroad and west of Buffalo connecting with the Michigan Central Railroad's Wolverine, taking a route through Southwestern Ontario. The train left New York at 2 pm and would arrive in Chicago at 2 pm the next day. The Wabash Railroad's #1-11 hitched with the train for coach and sleeper service that veered from the Michigan Central route from Detroit westward. It took the Wabash's most southernly route through Montpelier, Ohio.

Eastbound, the train carried the name, Lackawanna Limited. Full service to Chicago ended in 1941. The DLW portion continued between Buffalo, New York and Hoboken was continued to 1949 and in that year was given a renaming as the DLW's Phoebe Snow.

Wabash Railroad
The Wabash Railroad (reporting mark WAB) was a Class I railroad that operated in the mid-central United States. It served a large area, including track in the states of Ohio, Indiana, Illinois, Iowa, Michigan, and Missouri and the province of Ontario. Its primary connections included Chicago, Illinois; Kansas City, Missouri; Detroit, Michigan; Buffalo, New York; St. Louis, Missouri; and Toledo, Ohio.

The Wabash's major freight traffic advantage was the direct line from Kansas City to Detroit, without going through St. Louis or Chicago. Despite being merged into the Norfolk and Western Railway (N&W) in 1964, the Wabash company continued to exist on paper until the N&W merged into the Norfolk Southern Railway (NS) in 1982.