hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
AI-10-49
AI-10-49 is a small molecule inhibitor of leukemic oncoprotein CBFβ-SMHHC developed by the laboratory of John Bushweller (University of Virginia) with efficacy demonstrated by the laboratories of Lucio H. Castilla (University of Massachusetts Medical School) and Monica Guzman (Cornell University). AI-10-49 allosterically binds to CBFβ-SMMHC and disrupts protein-protein interaction between CBFβ-SMMHC and tumor suppressor RUNX1. This inhibitor is under development as an anti-leukemic drug.

RUNX1
Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) and it is a protein that is encoded by the RUNX1 gene, in humans.

RUNX1 is a transcription factor that regulates the differentiation of hematopoietic stem cells into mature blood cells.  In addition it plays a major role in the development of the neurons that  transmit pain. It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). RUNX proteins form a heterodimeric complex with CBFβ which confers increased DNA binding and stability to the complex.

Chromosomal translocations involving the RUNX1 gene are associated with several types of leukemia including M2 AML. Mutations in RUNX1 are implicated in cases of breast cancer.
Brand page
A brand page (also known as a page or fan page), in online social networking parlance, is a profile on a social networking website which is considered distinct from an actual user profile in that it is created and managed by at least one other registered user as a representation of a non-personal online identity. This feature is most used to represent the brands of organizations associated with, properties owned by, or general interests favored by a user of the hosting network.

While also being potentially manageable by more than one registered user, pages are distinguished from groups in that pages are usually designed for the managers to direct messages and posts to subscribing users (akin to a newsletter or blog) and promote a brand, while groups are usually and historically formed for discussion purposes.

Group (online social networking)
A group (often termed as a community, e-group or club) is a feature in many social networking services which allows users to create, post, comment to and read from their own interest- and niche-specific forums, often within the realm of virtual communities. Groups, which may allow for open or closed access, invitation and/or joining by other users outside the group, are formed to provide mini-networks within the larger, more diverse social network service. Much like electronic mailing lists, they are also owned and maintained by owners, moderators, or managers, who can edit posts to discussion threads and regulate member behavior within the group. However, unlike traditional Internet forums and mailing lists, groups in social networking services allow owners and moderators alike to share account credentials between groups without having to log in to every group.
Karingani language
Karingani is a Northwestern Iranian language and a dialect o Tati language of Iran. It is closely related to the Kalāsuri-Khoynarudi dialects and Harzandi and Kilit. It is spoken in East Azerbaijan Province, in the Dizmar district, Keringan, Kalasur and Khunirud villages.

Kalasur
Kalasur (Persian: كلاسور, also Romanized as Kalāsūr, Kalasoor, and Kelāsūr; also known as Keyālīsūr, Kialiasur, and Kyalyasur) is a village in Misheh Pareh Rural District, in the Central District of Kaleybar County, East Azerbaijan Province, Iran. At the 2006 census, its population was 108, in 22 families.
EGX-B
EGX-B is a serotonin 5-HT2A receptor agonist and putative serotonergic psychedelic which is under development for the treatment of depressive disorders. It acts as a agonist of the serotonin 5-HT2A receptor, shows high selectivity (>100-fold) for the serotonin 5-HT2A receptor over the serotonin 5-HT2B receptor, is much more potent as a serotonin 5-HT2A receptor agonist than psilocin, and produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. The drug is being developed by atai Life Sciences and EntheogeniX Biosciences. As of December 2023, it is in the preclinical research stage of development.

Binding selectivity
In chemistry, binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex. Binding selectivity describes how a ligand may bind more preferentially to one receptor than another. A selectivity coefficient is the equilibrium constant for the reaction of displacement by one ligand of another ligand in a complex with the substrate. Binding selectivity is of major importance in biochemistry and in chemical separation processes.
Marquez crater
Marquez crater is a meteorite crater located in Leon County, Texas near the small town of Marquez about 177 km (110 mi) northeast of Austin, Texas, United States.

It is 12.7 km (8 mi) in diameter and the age is estimated to be 58 ± 2 million years (Paleocene). The crater is not exposed at the surface, but some surface formations including the Marquez Dome are thought to be exposed portions of the rebound peak. This includes a circular region of disturbed Cretaceous sedimentary rocks roughly 1.2 km (0.75 mi) in diameter at the surface. This may be associated with a central peak rising at least 1,120 m (3,670 ft) above the base of the buried crater. The uplift was initially thought to indicate an underlying salt dome by early investigators, but this origin was ruled out by reflection seismology and the discovery of features like shatter cones strongly associated with meteoric origin.

Reflection seismology
Reflection seismology (or seismic reflection) is a method of exploration geophysics that uses the principles of seismology to estimate the properties of the Earth's subsurface from reflected seismic waves. The method requires a controlled seismic source of energy, such as dynamite or Tovex blast, a specialized air gun or a seismic vibrator. Reflection seismology is similar to sonar and echolocation.
Princess Brun Njua
Princess Brun Njua (born 26 January 1986) is a multi award-winning Cameroonian actress and Model. She came to prominence back in 2014 after appearing on the popular ITV TV series Judge Rinder. She is the recipient of a BEFFTA star award which she won back in 2016.

Judge Rinder
Judge Rinder is a British arbitration-based reality court show that aired on ITV from 11 August 2014 to 14 October 2020, with repeats continuing until 24 September 2021. The show depicts Robert Rinder as an arbitrator overseeing civil cases. Rinder began his career in criminal law in 2003. He is a barrister and wears his barrister robes while on the show, but does not wear the wig as is customary in the judiciary.

Rinder is a practising criminal barrister at 2 Hare Court Chambers in London and this is made clear on the show. As with other related court shows that inspired it, such as Judge Judy, Judge Mathis and The People's Court, any awards handed down by Rinder are paid by the production company rather than the loser.
Gleb Lutfullin
Gleb Olegovich Lutfullin (Russian: Глеб Олегович Лутфуллин; born 31 March 2004) is a Russian figure skater. He is the 2025 Russian national silver medalist, the winner of the junior Grand Prix stages in Russia and Poland (2021), and a Master of Sports of Russia (2023).

ISU Junior Grand Prix in Poland
The ISU Junior Grand Prix in Poland is an international figure skating competition sanctioned by the International Skating Union (ISU), organized and hosted by the Polish Figure Skating Association (Polish: Polski Związek Łyżwiarstwa Figurowego). It is held periodically as an event of the ISU Junior Grand Prix of Figure Skating (JGP), a series of international competitions exclusively for junior-level skaters. It has been held under several names during its history, including the Gdańsk Cup (2005), the Toruń Cup (2009, 2015), the Baltic Cup (2011, 2013, 2019, 2021, 2022), and the Solidarity Cup (2022, 2023, 2024). Medals may be awarded in men's singles, women's singles, pair skating, and ice dance. Skaters earn points based on their results at the qualifying competitions each season, and the top skaters or teams in each discipline are invited to then compete at the Junior Grand Prix of Figure Skating Final.
Sankt Augustin
Sankt Augustin (German pronunciation: [zaŋkt ˈaʊɡʊstiːn] ⓘ; Ripuarian: Sank Aujustin) is a town in the Rhein-Sieg district in North Rhine-Westphalia, Germany. It is named after the patron saint of the Steyler missionaries, Saint Augustine of Hippo (354-430). The missionaries established the "Saint Augustine Monastery" near the current town centre in 1913. The municipality of Sankt Augustin was established in 1969, and on September 6, 1977, Sankt Augustin acquired town privileges (German: Stadtrechte). Sankt Augustin is situated about 8 km northeast of Bonn and 8 km southwest of Siegburg. Sankt Augustin belongs to the economic region of Bonn/Rhein-Sieg as well as the scientific region of Bonn. With over 59,000 inhabitants, it is the second-largest town in the Rhein-Sieg district.

Rhein-Sieg-Kreis
The Rhein-Sieg-Kreis (Kölsch: Rhein-Siech-Kreis) is a Kreis (district) in the south of North Rhine-Westphalia, Germany. Neighboring districts are Rheinisch-Bergischer Kreis, Oberbergischer Kreis, Altenkirchen, Neuwied, Ahrweiler, Euskirchen, Rhein-Erft-Kreis, the urban district of Cologne. The federal city of Bonn is nearly completely surrounded by the district.
Achumbemo Kikon
Achumbemo Kikon (born 1976) is an Indian politician from Nagaland. He is an MLA from Bhandari Assembly constituency, which is reserved for Scheduled Tribes, in Wokha District. He won the 2023 Nagaland Legislative Assembly election, representing Naga People's Front.

2023 Nagaland Legislative Assembly election
Legislative Assembly elections were held in Nagaland on 27 February 2023 to elect all 60 members of the Nagaland Legislative Assembly. The votes were counted and the results were declared on 2 March 2023.

The election marked a historic moment as it saw the first-ever election of two female MLAs to the Nagaland Assembly.
June 2016 Tel Aviv shooting
In a terrorist attack in Tel Aviv, Israel, on 8 June 2016, two Palestinian gunmen opened fire on patrons at the Max Brenner Cafe at the Sarona Market, killing four people and injuring seven others. The perpetrators were caught alive by the security forces and put in custody. According to an official indictment filed by the Tel Aviv District Prosecutor's Office the perpetrators were inspired by the Islamic State group.

Sarona Market
32°4′5″N 34°46′55″E﻿ / ﻿32.06806°N 34.78194°E﻿ / 32.06806; 34.78194

Sarona Market (Hebrew: שרונה מרקט) is the largest enclosed culinary market in Israel, located at the southern edge of the city's Templer Colony restoration project in Sarona, Tel Aviv. Sarona Market was constructed by Gindi Holdings and opened in 2015, and is the first indoor market in Israel.  After its establishment, other enclosed markets were built throughout the country. In Sarona Market, there are about 90 businesses, including retail stores, food stands and restaurants. The complex is a popular tourist attraction.
Serge Koussevitzky
Serge Koussevitzky (born Sergey Aleksandrovich Kusevitsky; Russian: Сергей Александрович Кусевицкий, IPA: [sʲɪrˈɡʲej ɐlʲɪkˈsandrəvʲɪtɕ kʊsʲɪˈvʲitskʲɪj];  26 July [O.S. 14 July] 1874 – 4 June 1951) was a Russian and American conductor, composer, and double-bassist, known for his long tenure as music director of the Boston Symphony Orchestra from 1924 to 1949.

Music director
A music director, musical director or director of music is a person responsible for the musical aspects of a performance, production, or organization. This would include the artistic director and usually chief conductor of an orchestra or concert band, the director of music of a film, the director of music at a radio station, the person in charge of musical activities or the head of the music department in a school, the coordinator of the musical ensembles in a university, college, or institution (but not usually the head of the academic music department), the head bandmaster of a military band, the head organist and choirmaster of a church, or an organist and master of the choristers (the title given to a director of music at a cathedral, particularly in England).
Habesha Breweries S.C.
Habesha Breweries S.C. is an Ethiopian brewery and beverage making company owned by Dutch company Swinkels Family Brewers Holding N.V with 60% share, 8,000 local shareholders and Linssen Participations B.V. Founded in 2009, Habesha is the largest beverage producing company with annual production capacity of 650,000 hectoliters to 1.5 million hectoliters in 2017. Its brewery plant is located in Debre Birhan with a plan of its strategic market in Addis Ababa and Debre Birhan.

In 2019, the company signed 50 million euro agreement with the International Finance Corporation (IFC) to extract barley source from smallholder farmers. It was funded by the Dutch Development Bank, Rabobank and ING Bank. The company commenced developmental program of barley chain producing. Since 2021, the current CEO of Habesha Breweries is Omo Ohiwerei.

International Finance Corporation
The International Finance Corporation (IFC) is an international financial institution headquartered in Washington, D.C., and a member of the World Bank Group. Established in 1956 as the private-sector arm of the World Bank Group, the IFC provides investment, advisory, and asset-management services to support private-sector development in developing countries. Its goal is to help people achieve better living standards by mobilizing financial resources for private enterprises.
Castelfiorentino Madonna
The Castelfiorentino Madonna is a tempera-and-gold-on-panel painting attributed to the Italian painter Cimabue, dating to c.1283–1284. Showing a half-length Madonna Odigitria-type Madonna, it originally hung in the collegiate church of Santi Lorenzo e Leonardo but now hangs in the Museo di Santa Verdiana in Castelfiorentino.

Over time it has been attributed to various artists, particularly Duccio di Buoninsegna due to its similarities with his Crevole Madonna or Cimabue or a collaboration between the two. After a 1930–1931 restoration by Giorgina Lucarini it was more precisely attributed to Cimabue by most art historians, including Miklos Boskovitz and Luciano Bellosi, the two main experts on medieval Tuscan art, drawing on Duccio's slightly earlier Crevole Madonna. There is also a theory that a young Giotto could have contributed to the work.

Duccio
Duccio di Buoninsegna (UK: /ˈduːtʃioʊ/ DOO-chee-oh, Italian: [ˈduttʃo di ˌbwɔninˈseɲɲa]; c. 1255/1260 – c. 1318/1319), commonly known as just Duccio, was an Italian painter active in Siena, Tuscany, in the late 13th and early 14th century. He was hired throughout his life to complete many important works in government and religious buildings around Italy. Duccio is considered one of the greatest Italian painters of the Middle Ages, and is credited with creating the painting styles of Trecento Gothic style and the Sienese school.
Zoobles! Spring to Life!
Zoobles! Spring to Life! is a pet simulation role-playing game based on the Zoobles! toyline by Spin Master. Developed by Japanese game developer Now Production and published by Activision, the game was released on the Nintendo DS in November 2011 in United States and Europe.

Simulation video game
Simulation video games are a diverse super-category of video games, generally designed to closely simulate real world activities. A simulation game attempts to copy various activities from real life in the form of a game for various purposes such as training, analysis, prediction, or entertainment. Usually there are no strictly defined goals in the game, and the player is allowed to control a character or environment freely. Well-known examples are war games, business games, and role play simulation. From three basic types of strategic, planning, and learning exercises: games, simulations, and case studies, a number of hybrids may be considered, including simulation games that are used as case studies. Comparisons of the merits of simulation games versus other teaching techniques have been carried out by many researchers and a number of comprehensive reviews have been published.
Second Pinal County Courthouse
The Second Pinal County Courthouse, built in 1891, is an historic three-story redbrick courthouse located at Pinal and 12th streets in Florence, Pinal County, Arizona, United States. Designed by prominent Arizona architect James M. Creighton in the Late Victorian Revival style of architecture, it is Pinal County's second courthouse. It is topped by an ornate clock tower, but due to a lack of funds, the clockworks was never installed. Instead a clock was painted on it with the hands set at 11:44. Replaced in 1961 by another courthouse, it fell into disrepair and it was closed in 2005. In 2007 it was declared to be one of the most endangered historic buildings in Arizona. In January 2011, the county supervisors approved a plan to renovate the building and restore it to its former glory so that it could be used by the supervisors and other county entities. On August 2, 1978, it was added to the National Register of Historic Places.

Clock tower
Clock towers are a specific type of structure that house a turret clock and have one or more clock faces on the upper exterior walls. Many clock towers are freestanding structures but they can also adjoin or be located on top of another building. Some other buildings also have clock faces on their exterior but these structures serve other main functions.

Clock towers are a common sight in many parts of the world with some being iconic buildings. One example is the Elizabeth Tower in London (usually called "Big Ben", although strictly this name belongs only to the bell inside the tower).
A Libyan Myth
A Libyan Myth (Ancient Greek: Λιβυκὸς Μῦθος, romanized: Libykos Mythos, Oration 5 in modern corpora) is a short speech or speech-fragment by Dio Chrysostom, telling the story of a mythical creature from Libya, perhaps Lamia, as an allegory for human passions, especially lust. The work is also important for an understanding of Dio's ideas about myth as allegory.
It is debated whether the work is a stand-alone speech or an alternative ending to On Kingship IV.

Dio Chrysostom
Dio Chrysostom (/ˈdiːoʊ ˈkrɪsəstəm, krɪˈsɒstəm/; Ancient Greek: Δίων Χρυσόστομος Dion Chrysostomos), Dio of Prusa or Cocceianus Dio (c. 40 – c. 115 AD), was a Greek orator, writer, philosopher and historian of the Roman Empire in the 1st century AD.  Eighty of his Discourses (or Orations; Λόγοι) are extant, as well as a few letters, a mock essay Encomium on Hair, and a few other fragments. His sobriquet Chrysostom comes from the Greek chrysostomos, which literally means "golden-mouthed".
Bruce Hopkins (actor)
Raymond Bruce Hopkins (born 25 November 1955) is a New Zealand actor, most famous for his portrayal of Gamling in The Lord of the Rings film trilogy by Peter Jackson and for playing the voice of evil alien Choobo on Power Rangers Ninja Storm. He also founded ActionActors, an actor-specific temporary employment agency, with Bruce Hurst.

Hopkins was born in Invercargill, the son of Colleen Marguerite and Bill Hopkins, a crayfisherman. He was a crayfisherman and a PE teacher before dedicating himself to the performing arts. He has worked as a professional dancer, theater company actor, television and film actor, voice actor, and radio host.

Crayfish
Crayfish are freshwater crustaceans belonging to the infraorder Astacidea, which also contains lobsters. Taxonomically, they are members of the superfamilies Astacoidea and Parastacoidea. They breathe through feather-like gills. Some species are found in brooks and streams, where  fresh water is running, while others thrive in swamps, ditches, and paddy fields. Most crayfish cannot tolerate polluted water, although some species, such as Procambarus clarkii, are hardier. Crayfish feed on animals and plants, either living or decomposing, and detritus.

The term "crayfish" is applied to saltwater species in some countries.
Kerala Sahitya Akademi Award for Miscellaneous Works
The Kerala Sahitya Akademi Award for Miscellaneous Works was an award given every year by the Kerala Sahitya Akademi (Kerala Literary Academy) to Malayalam writers for writing miscellaneous works of literary merit. It was one of the  categories of the Kerala Sahitya Akademi Award.  The award was established in 1969 and was discontinued from the year 1991, since many new categories were added in 1992.

Kerala Sahitya Akademi
The Kerala Sahitya Akademi or Academy for Malayalam Literature is an autonomous body established to promote the Malayalam language and literature. It is situated in the city of Thrissur, Kerala in India.
Paul Meger
Paul Carl Meger (February 17, 1929 – August 27, 2019) was a Canadian professional ice hockey forward. Meger played his entire National Hockey League (NHL) career with the Montreal Canadiens, winning the Stanley Cup in 1953. His career lasted from 1949 until 1955. Meger was born in Watrous, Saskatchewan, but grew up in Selkirk, Manitoba.

Selkirk, Manitoba
Selkirk is a city in the western Canadian province of Manitoba, located on the Red River about 22 kilometres (14 mi) northeast of Winnipeg, the provincial capital. It has a population of 10,504 as of the 2021 census.

The mainstays of the local economy are tourism, a steel mill, and a psychiatric hospital. A vertical lift bridge over the Red River connects Selkirk with the smaller town of East Selkirk. The city is connected to Winnipeg via Highway 9 and is served by the Canadian Pacific Railway.

The city was named in honour of the Scotsman Thomas Douglas, 5th Earl of Selkirk, who obtained the grant to establish a colony in the Red River area in 1813.
Imidazole N-acetyltransferase
In enzymology, an imidazole N-acetyltransferase (EC 2.3.1.2) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + imidazole  CoA + N-acetylimidazole

Thus, the two substrates of this enzyme are acetyl-CoA and imidazole, whereas its two products are CoA and N-acetylimidazole.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups.  The systematic name of this enzyme class is acetyl-CoA:imidazole N-acetyltransferase. Other names in common use include imidazole acetylase, and imidazole acetyltransferase.

Imidazole
Imidazole (ImH) is an organic compound with the formula (CH)2NHCHN. It is a white or colourless solid that is soluble in water, producing a mildly alkaline solution. It can be classified as a heterocycle, specifically as a diazole.

Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.

When fused to a pyrimidine ring, it forms a purine, which is the most widely occurring nitrogen-containing heterocycle in nature.

The name "imidazole" was coined in 1887 by the German chemist Arthur Rudolf Hantzsch (1857–1935).