hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Icalcaprant
Icalcaprant (developmental code name CVL-354) is a κ-opioid receptor (KOR) antagonist which is under development for the treatment of major depressive disorder and substance-related disorders. It is taken by mouth.

It acts as a selective antagonist of the KOR. The drug is also more weakly an antagonist of the μ-opioid receptor (MOR), with about 31-fold lower affinity and 27-fold lower inhibitory potency at the MOR relative to the KOR.

It was originated by Pfizer and is under development by Cerevel Therapeutics (a subsidiary of AbbVie). As of September 2022, icalcaprant is in phase 1 clinical trials for major depressive disorder and is in the preclincal stage of development for substance-related disorders.

Phases of clinical research
The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases start with testing for drug safety in a few human subjects, then expand to many study participants (potentially tens of thousands) to determine if the treatment is effective. Clinical research is conducted on drug candidates, vaccine candidates, new medical devices, and new diagnostic assays.
Bondage harness
A bondage harness is a piece of BDSM equipment worn for the purposes of bondage. The harness typically consists of a series of leather straps, usually between 1 and 2 cm wide, attached together in such a way as to allow a person to "wear" the item. Customization of the harness may be needed depending on the specific individual's body.

The item is very closely associated with BDSM play, and is often immediately identifiable as being related to kink. For this reason, it is sometimes worn publicly as a way to reference fetish culture and gain attention. Often the image of a person in a bondage harness is used in media as a trope for "someone into fetish play", such as in the Sin City comic book series.

Sin City
Sin City is a series of neo-noir comics by American comic book writer-artist Frank Miller. The first story originally appeared in Dark Horse Presents Fifth Anniversary Special (April 1991), and continued in Dark Horse Presents 51–62 from May 1991 to June 1992, under the title of Sin City, serialized in thirteen parts. Several other stories of variable lengths have followed. The intertwining stories, with frequently recurring characters, take place in Basin City.

A film adaptation of Sin City, co-directed by Robert Rodriguez and Miller, was released on April 1, 2005. A sequel, Sin City: A Dame to Kill For, was released on August 22, 2014.
Lists of gymnasts
Gymnasts are people who participate in the sport of gymnastics. This sport contains disciplines that include, but are not limited to:

This list is of those who are considered to be notable in their chosen discipline.

See gymnasium (ancient Greece) for the origin of the word gymnast from gymnastikos.

Gymnasium (ancient Greece)
The gymnasium (Ancient Greek: γυμνάσιον, romanized: gymnásion) in Ancient Greece functioned as a training facility for competitors in public games. It was also a place for socializing and engaging in intellectual pursuits. The name comes from the Ancient Greek term gymnós, meaning "naked" or "nude". Only adult male citizens were allowed to use the gymnasia.

Athletes competed nude, a practice which was said to encourage aesthetic appreciation of the male body, and to be a tribute to the gods. Gymnasia and palaestrae (wrestling schools) were under the protection and patronage of Heracles, Hermes and, in Athens, Theseus.
MAPKAPK5
MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene.
The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.

A link between Alzheimer's disease and reduced levels of MAPKAPK5 has been proposed. Clinical trials may confirm if this is the case.

Threonine
Threonine (symbol Thr or T) is an amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH+3 form when dissolved in water), a carboxyl group (which is in the deprotonated −COO− form when dissolved in water), and a side chain containing a hydroxyl group, making it a polar, uncharged amino acid. It is essential in humans, meaning the body cannot synthesize it: it must be obtained from the diet. Threonine is synthesized from aspartate in bacteria such as E. coli. It is encoded by all the codons starting AC (ACU, ACC, ACA, and ACG).

Threonine sidechains are often hydrogen bonded; the most common small motifs formed are based on interactions with serine: ST turns, ST motifs (often at the beginning of alpha helices) and ST staples (usually at the middle of alpha helices).
Mamphela Ramphele
Mamphela Aletta Ramphele (/ˈmʌmpiːlə ˈrʌmpiːli/; born 28 December 1947) is a South African politician, anti-apartheid activist, medical doctor and businesswoman. She was a partner of anti-apartheid activist Steve Biko, with whom she had two children. She is a former vice-chancellor at the University of Cape Town and a former managing director at the World Bank. Ramphele founded the political party Agang South Africa in February 2013 but withdrew from politics in July 2014. Since 2018, she has been the co-president of the Club of Rome.

University of Natal
The University of Natal was a university in the former South African province Natal which later became KwaZulu-Natal. The University of Natal no longer exists as a distinct legal entity, as it was incorporated into the University of KwaZulu-Natal on 1 January 2004. It was founded in 1910 as the Natal University College in Pietermaritzburg and expanded to include a campus in Durban in 1931. In 1947, the university opened a medical school for non-white students in Durban. The Pietermaritzburg campus was known for its agricultural engineering programmes, hence the nickname "the farmers" whilst the Durban campus was known as "the engineers," as it concentrated on other engineering programmes.

On 1 January 2004, the University of Natal was merged with the University of Durban-Westville to create a new legal entity called the University of KwaZulu-Natal, as part of a broader reorganisation of South African universities.
The Foundling and Other Tales of Prydain
The Foundling and Other Tales of Prydain is a collection of short high fantasy stories for children by Lloyd Alexander and illustrator Margot Zemach. The 1973 first edition includes six stories; the 1982 edition, eight. The 1999 edition adds a map of Prydain and a pronunciation guide .
All are prequels to The Chronicles of Prydain, Alexander's award-winning series of five novels published 1964 to 1968.

Prequel
A prequel is a literary, dramatic or cinematic work whose story precedes that of a previous work, by focusing on events that occur before the original narrative. A prequel is a work that forms part of a backstory to the preceding work.

The term "prequel" is a 20th-century neologism from the prefix "pre-" (from Latin prae, "before") and "sequel".

Like sequels, prequels may or may not concern the same plot as the work from which they are derived. More often they explain the background that led to the events in the original, but sometimes the connections are not completely explicit. Sometimes prequels play on the audience's knowledge of what will happen next, using deliberate references to create dramatic irony.
Injong of Goryeo
Injong (29 October 1109 – 10 April 1146), personal name Wang Hae, was the 17th monarch of the Korean Goryeo dynasty. He was the eldest son of King Yejong and Queen Sundeok, the daughter of Yi Cha-gyŏm. His reign saw two major internal crises that nearly ended the Goryeo dynasty, the collapse of the Northern Song dynasty, and the establishment of the Jin dynasty as the dominant power in East Asia.

Liang (mass)
Liang (simplified Chinese: 两; traditional Chinese: 兩; pinyin: liǎng), or leung in Cantonese, liae in Wenzhounese, liong in Hakka, lian in Shanghainese, also called "Chinese ounce" or "tael", is a traditional Chinese unit for weight measurement. It originated in China before being introduced to neighboring countries in East and Southeast Asia.

Modern standards for the liang include 1/10 jin (50 grams) in mainland China, 37.5 grams in Taiwan, Korea and Thailand,
37.799 grams in Hong Kong, Singapore and Malaysia, and 37.8 grams in Vietnam.

Liang is mostly used in traditional markets, and is a well-known measure for gold, silver and Chinese medicines.
Kühner
Kühner, also spelled Kuehner, and sometimes anglicised as Kuhner, is a German surname.

Notable people with this surname include:

Herbert Kuhner (born 1935) is an Austrian writer and translator

Jeff Kuhner (born 1969), Canadian-American radio host

Jochen Kühner (born 1980), German rower

Jody Kuehner (born c. 1980), better known as Cherdonna Shinatra, American dancer

Martin Kühner (born 1980), German rower

Nikolai Kuehner (1877-1955), Soviet scientist

Raphael Kühner (1802-1878), German classical scholar

Robert Kühner (1903-1996), French mycologist

Sebastian Kühner (born 1987), German volleyball player

Raphael Kühner
Raphael Kühner (22 March 1802 – 16 April 1878) was a German classical scholar.

He was born in Gotha and educated at the Illustrious Gymnasium and the University of Göttingen.

From 1824 to 1863, Kühner taught classes at the lyceum in Hanover.

He published an edition of the Tusculanae Disputationes of Cicero (1829; fifth edition, 1874). His large Greek grammar, Ausführliche Grammatik der griechischen Sprache (two volumes, 1834–35), was translated into English by William Edward Jelf (1842–45). An enlarged third edition in four volumes was produced by Friedrich Wilhelm Blass and Bernhard Gerth (1890–1904). His large Latin grammar, Ausführliche Grammatik der lateinischen Sprache (two volumes, 1877–79), has been reedited in enlarged form by Friedrich Holzweissig and Carl Stegmann (Hannover, 1912–14). His smaller Greek and Latin grammars passed through many editions.

He died in Hanover.
Norman Margolus
Norman H. Margolus (born 1955) is a Canadian-American physicist and computer scientist, known for his work on cellular automata and reversible computing. He is a research affiliate with the Computer Science and Artificial Intelligence Laboratory at the Massachusetts Institute of Technology.

MIT Computer Science and Artificial Intelligence Laboratory
Computer Science and Artificial Intelligence Laboratory (CSAIL) is a research institute at the Massachusetts Institute of Technology (MIT) formed by the 2003 merger of the Laboratory for Computer Science (LCS) and the Artificial Intelligence Laboratory (AI Lab). Housed within the Ray and Maria Stata Center, CSAIL is the largest on-campus laboratory as measured by research scope and membership. It is part of the Schwarzman College of Computing but is also overseen by the MIT Vice President of Research.
2022 President's Cup – Women's doubles
Alina Charaeva and Maria Timofeeva were the defending champions but chose not to participate.

Mariia Tkacheva and Anastasia Zolotareva won the title, defeating Momoko Kobori and Moyuka Uchijima in the final, 4–6, 6–1, [10–4].

Maria Timofeeva
Maria Glebovna Timofeeva (Russian: Мари́я Гле́бовна Тимофе́ева, IPA: [mɐˈrʲijə tʲɪmɐˈfʲe(j)ɪvə]; born 18 November 2003) is a Russian-born Uzbekistani professional tennis player. She has a career-high WTA singles ranking of No. 93, achieved on 1 April 2024 and a best doubles ranking of No. 179, achieved on 13 February 2023.

Timofeeva has won one WTA Tour title in singles at 2023 Budapest Grand Prix. She also earned five singles and six doubles titles on the ITF Women's Circuit.
Paul Shkordoff
Paul Shkordoff is a Canadian filmmaker and screenwriter from Toronto, Ontario. He is most noted for his 2020 short film Benjamin, Benny, Ben, which won the award for the award for Best Canadian Short Film at the 2020 Toronto International Film Festival and was a Canadian Screen Award nominee for Best Live Action Short Drama at the 9th Canadian Screen Awards in 2021.

He has also directed the short films Grove (2020) and Twelve Hours (2021), and the music video "Somnambule" for Jean-Michel Blais.

9th Canadian Screen Awards
The 9th Canadian Screen Awards were presented by the Academy of Canadian Cinema and Television from 17–20 May 2021 to honour achievements in Canadian film, television, and digital media production in 2020. The presentations were held as a series of virtual events due to the COVID-19 pandemic.

Most nominations were announced on 3 March 2021; however, the nominations and winners in sports broadcasting categories were announced at a later date. In the film categories, the film Blood Quantum received the most award nominations (10), and ultimately the most wins (6), while in the television categories, Schitt's Creek also received both the most award nominations (21) and wins (8).  No new winners were named for the Academy's annual special awards; instead, the honorees previously named in 2020, most notably Alex Trebek, were celebrated and highlighted.
Malawi Young Pioneers
The Malawi Young Pioneers (MYP) were the paramilitary wing of the Malawi Congress Party. Their Commander-in-Chief was President Hastings Banda. They originally were supposed to function as a national youth service program with a development agenda. However, over time, they strayed away from this mission and became an intricate network of espionage and repression. The Young Pioneers organization was a major instrument of Dr Banda's one-party dictatorship and domestic terrorism. Pioneers bore arms, conducted espionage and intelligence operations, and were Banda's most trusted bodyguards around Hastings Kamuzu Banda. Both the Malawi Army and Police resented the Pioneers for usurping their roles as security agents.

Domestic terrorism
Domestic terrorism or homegrown terrorism is a form of terrorism in which victims "within a country are targeted by a perpetrator with the same citizenship" as the victims. There are various different definitions of terrorism, with no universal agreement about it.

Unlike domestic terrorism, state terrorism is that perpetrated by nation states, but is not considered such by the state conducting it, making legality a grey area.
Gulab jamun
Gulab jamun is a sweet confectionery or dessert, originating in the Indian subcontinent, and a type of mithai popular in India, Bangladesh, Nepal, Pakistan, the Maldives, as well as Myanmar. It is also common in nations with substantial populations of people with South Asian heritage, such as Mauritius, Fiji, Gulf states, the Malay Peninsula, United Kingdom, United States, Canada, South Africa, and the Caribbean (Jamaica, Trinidad and Tobago, Guyana, and Suriname).

It is made mainly from milk solids, traditionally khoya, which is milk reduced to the consistency of a soft dough. Modern recipes call for dried or powdered milk instead of khoya. It is often garnished with dried nuts, such as almonds and cashews, to enhance flavour.

Arab states of the Persian Gulf
The Arab states of the Persian Gulf (Arabic: دول الخليج الفارسي, romanized: duwal al-Khalīj al-ʿfarsi), are a group of Arab states bordering the Persian Gulf, including Bahrain, Kuwait, Iraq, Oman, Qatar, Saudi Arabia, and the United Arab Emirates.

The term has been used in different contexts to refer to a number of Arab states in the Persian Gulf region. The prominent political union of the region is the Gulf Cooperation Council, which includes all Persian Gulf states except Iraq. Most Persian Gulf states are former protectorates of the British Empire.
2002 Supersport World Championship
The 2002 Supersport World Championship was the sixth season of the Supersport World Championship. The season was held over 12 races following the Superbike World Championship calendar except a race at Laguna Seca. Beginning on 10 March at Circuit Ricardo Tormo in Spain, and finished on 29 September at Autodromo Enzo e Dino Ferrari in Italy.

Frenchman Fabien Foret won the title after beating the closest rival Katsuaki Fujiwara.

Supersport World Championship
The Supersport World Championship, abbreviated to WorldSSP, is a motorcycle racing competition on hard-surfaced circuits, based on mid-sized sports motorcycles. Competition machines were originally based on production-based motorcycles with 600 cc to 955 cc engines, depending on the number of cylinders. After trials in UK national series British Supersport, from 2022 the regulations have changed to allow eligibility of larger-displacement engines, to reflect the engine sizes being produced and encourage different manufacturers.

The championship runs as a support class to the Superbike World Championship, which is similarly based on large production-based sports motorcycles. The championship, organized and promoted as its parent series by FGSport—renamed Infront Motor Sports in 2008—until 2012 and by Dorna from the 2013 season onwards, is sanctioned by the FIM.
Czaja
Czaja is a surname. Notable people with the surname include:

Dominik Czaja (born 1995), Polish rower

Emile Czaja (1909–1970), Australian-Indian wrestler

Herbert Czaja (1914–1997), German politician

Jakub Czaja (born 1980), Polish athlete

Mario Czaja (born 1975), German politician

Mary Czaja (born 1963), American businesswoman and politician

Wiesław Czaja (born 1952), Polish volleyball player and coach

Zbigniew Czaja (born 1958), Polish slalom canoeist

Jakub Czaja
Jakub Czaja (born 12 September 1980 in Gdańsk) is a retired Polish athlete who specialised in the 3000 metres steeplechase. He represented his country at the 2004 Summer Olympics failing to qualify for the final. His biggest success is the silver medal at the 2001 Summer Universiade.
Win the Battle
Win The Battle is the 12th studio album by Canadian punk rock band D.O.A. The Slogan on the back cover (Talk - Action = 0) was later used as the title for their 2010 release.
All songs are written by Joe Keithley except where noted.

The album is dedicated to the memory of Ginger Goodwin (early BC labour organizer) and to Dimwit. Dimwit was Chuck Biscuits's brother and was in The Skulls together with Joe Keithley. The last song on the album is about Dimwit and how he died.

The Skulls (Canadian band)
The Skulls were an early Vancouver punk rock band, whose members would later found two of the area's bands: D.O.A. in 1978, and The Subhumans. They toured heavily and issued a demo, but never released any albums.
London 2 North East
Counties 1 Eastern Counties (formerly London 2 North East) is an English level 7 Rugby Union League. When this division began in 1987 it was known as London 3 North East, changing to its current name ahead of the 2009–10 season. Following the RFU's Adult Competition Review, from season 2022–23 it adopted its current name Counties 1 Eastern Counties.

The current champions are Norwich.

Sudbury RUFC
Sudbury Rugby Union Football Club is a rugby union club located in Great Cornard near Sudbury, Suffolk. The first XV currently play in Regional 1 South East, a fifth tier league in the English rugby union system.
Saeko Shimazu
Saeko Shimazu (島津 冴子, Shimazu Saeko, born September 8, 1959) is a Japanese actress, voice actress and narrator from Isehara. Shimazu is notable for having had voice roles in all four of the major anime television series based on the works of Rumiko Takahashi - she played Shinobu Miyake in Urusei Yatsura, Sayoko Kuroki in Maison Ikkoku, Kodachi Kuno in Ranma ½, and Abi-hime in Inuyasha. Shimazu is currently a freelancer.

Rumiko Takahashi
Rumiko Takahashi (高橋 留美子, Takahashi Rumiko; born October 10, 1957) is a Japanese manga artist. With a career of several commercially successful works, beginning with Urusei Yatsura in 1978, she is one of Japan's best-known and wealthiest manga artists. Her works are known worldwide, where they have been translated into a variety of languages, with over 230 million copies in circulation; making Takahashi one of the best-selling authors of all time. She has won the Shogakukan Manga Award twice, once in 1980 for Urusei Yatsura and again in 2001 for Inuyasha, and the Seiun Award twice, once in 1987 for Urusei Yatsura and again in 1989 for Mermaid Saga. She also received the Grand Prix de la ville d'Angoulême in 2019, becoming the second woman and second Japanese to win the prize. In 2020, the Japanese government awarded Takahashi the Medal with Purple Ribbon for her contributions to the arts.
Trichloromethyl group
The trichloromethyl group is a functional group that has the formula −CCl3. The naming of this group is derived from the methyl group (which has the formula −CH3), by replacing each hydrogen atom by a chlorine atom. Compounds with this group are a subclass of the organochlorines.

Trichloromethyl is an electron withdrawing group owing to the electronegativity of the three chlorides.

Electron-withdrawing group
An electron-withdrawing group (EWG) is a group or atom that has the ability to draw electron density toward itself and away from other adjacent atoms. This electron density transfer is often achieved by resonance or inductive effects. Electron-withdrawing groups have significant impacts on fundamental chemical processes such as acid-base reactions, redox potentials, and substitution reactions.
Prümerburg
The Prümerburg is a ruined hill castle on a roughly 30-metre-high lias-sandstone rock on the upper edge of the valley of the Prüm in the municipality of Prümzurlay in the county of Bitburg-Prüm in the German state of Rhineland-Palatinate.

Bitburg-Prüm
The Eifelkreis Bitburg-Prüm (Luxembourgish: Äifelkrees Béibreg-Prüm) is a district in Rhineland-Palatinate, Germany. It is bounded by (from the west and clockwise) Luxembourg, Belgium and the districts of Euskirchen, Vulkaneifel, Bernkastel-Wittlich and Trier-Saarburg.
Milan Dunović
Milan Dunović is a Bosnian Serb politician. He is a former Vice President of the Federation of Bosnia and Herzegovina from 2015 to 2023.

Dunović was born on 22 July 1974 in Sarajevo. He graduated from the University of Sarajevo. During the Bosnian War, he actively participated in the defense of Sarajevo and Bosnia and Herzegovina. After the war, he worked in BH Pošta.

In 2013, he became a member of the Democratic Front party. In February 2015, he was appointed to the position of Vice President of the Federation of Bosnia and Herzegovina as Serb representative. He was Vice President of the Federation of Bosnia and Herzegovina from February 2015 to February 2023. He is a current member of House of Representatives.

In 2017, he signed the Declaration on the Common Language of the Croats, Serbs, Bosniaks and Montenegrins.

BH Pošta
BH Pošta, officially Više Javno preduzeće BH Pošta d.o.o., is one of three companies responsible for postal service in Bosnia and Herzegovina. The other two are Pošte Srpske and Hrvatska pošta Mostar. BH Pošta operates mainly in Bosniak-majority areas in the Federation of Bosnia and Herzegovina. BH Pošta is the largest postal operator in Bosnia and Herzegovina with a wide network of post offices consisting of 386 units with 822 active counters in total, providing a full spectrum of domestic and international postal services.