hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Thymidylate synthase inhibitor
Thymidylate synthase inhibitors are chemical agents which inhibit the enzyme thymidylate synthase and have potential as an anticancer chemotherapy. This inhibition prevents the methylation of C5 of deoxyuridine monophosphate (dUMP) thereby inhibiting the synthesis of deoxythymidine monophosphate (dTMP).  The downstream effect is promotion of cell death because cells would not be able to properly undergo DNA synthesis if they are lacking dTMP, a necessary precursor to dTTP.
Five agents were in clinical trials in 2002: raltitrexed, pemetrexed, nolatrexed, Plevitrexed( ZD9331/BGC9331), and GS7904L.

Examples include

Raltitrexed, used for colorectal cancer since 1998

Fluorouracil, used for colorectal cancer

BGC 945/ ONX-0801

OSI-7904L

CB300638

Methylation
Methylation, in the chemical sciences, is the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group. Methylation is a form of alkylation, with a methyl group replacing a hydrogen atom.  These terms are commonly used in chemistry, biochemistry, soil science, and biology.

In biological systems, methylation is catalyzed by enzymes; such methylation can be involved in modification of heavy metals, regulation of gene expression, regulation of protein function, and RNA processing. In vitro methylation of tissue samples is also a way to reduce some histological staining artifacts. The reverse of methylation is demethylation.
Mingw-w64
Mingw-w64 is a free and open-source suite of development tools that generate Portable Executable (PE) binaries for Microsoft Windows. It was forked in 2005–2010 from MinGW (Minimalist GNU for Windows).

Mingw-w64 includes a build of the GNU Compiler Collection (GCC) targeting the MinGW-w64 platform, GNU Binutils for Windows (assembler, linker, archive manager), a set of freely distributable Windows specific header files and static import libraries for the Windows API, a Windows-native version of the GNU Project's GNU Debugger, and miscellaneous utilities.

Mingw-w64 can be run natively on Microsoft Windows, cross-hosted on Linux (or other Unix), or "cross-native" on MSYS2 or Cygwin. Mingw-w64 can generate 32-bit and 64-bit executables for x86 under the target names i686-w64-mingw32 and x86_64-w64-mingw32.

Linker (computing)
A linker or link editor is a computer program that combines intermediate software build files such as object and library files into a single executable file such as a program or library. A linker is often part of a toolchain that includes a compiler and/or assembler that generates intermediate files that the linker processes. The linker may be integrated with other toolchain tools such that the user does not interact with the linker directly.

A simpler version that writes its output directly to memory is called the loader, though loading is typically considered a separate process.
Wasserstein Perella & Co.
Wasserstein Perella & Co. was a boutique investment bank established by Bruce Wasserstein, Joseph R. Perella, Bill Lambert, and Charles Ward in 1988, former bankers at First Boston Corp., until its eventual sale to Dresdner Bank in 2000 for some $1.4 billion in stock. The private equity business of the investment firm was not included in the sale and was to be sold off to existing Wasserstein shareholders.

Union Bancaire Privée UK
51°30′41″N 0°5′0″W﻿ / ﻿51.51139°N 0.08333°W﻿ / 51.51139; -0.08333

Union Bancaire Privée UK is a private bank owned by Union Bancaire Privée that offers financial services from offices throughout the United Kingdom, Channel Islands and Gibraltar.
El Chinal
El Chinal is a town of the Álamos Municipality located in the southeast of the Mexican state of Sonora, close to the boundary with the states of Chihuahua and Sinaloa.  It is located 57.2 km southeast of Álamos and 47.8 kilometers Northwest of El Fuerte, in Sinaloa.  It lies northwest of Casanate in valley among the hills east of the Rio Cuchujaqui at an elevation of 243 meters.

El Chinal is the eighth largest population of the municipality according to the data of the Census of Population and Housing made in 2010 by the National Institute of Statistics and Geography (INEGI). El Chinal has a total of 342 inhabitants. It also has a municipal police station.

El Fuerte, Sinaloa
El Fuerte (Spanish: [el ˈfweɾte] ⓘ) is a city and El Fuerte Municipality its surrounding municipality in the northwestern Mexican state of Sinaloa. The city population reported in the 2010 census was 12,566 people.

El Fuerte, meaning "The Fort", was given a Pueblo Mágico ("Magical Town") touristic label in 2009, due to its many attractions, its historical importance and its appealing small-town colonial aura.
Rongxian Giant Buddha
The Rongxian Giant Buddha (simplified Chinese: 荣县大佛; traditional Chinese: 榮縣大佛; pinyin: Róngxìan Dàfó) formerly romanized as Yong-hien or Hong-yien, is a 36.7-metre (120 ft) tall stone statue, built around 817 (during the Tang dynasty), depicting Shakyamuni. It is 90 kilometres east of the Leshan Giant Buddha. The Buddha is carved out of the cliff face of a stone hill that lies to the north east of Rongxian and the Rongxi River in the eastern part of Sichuan province in China. Standing 414 metres above sea level, the stone sculpture overlooks the town of Rongxian below its feet. After the Leshan Giant Buddha, it is the second tallest pre-modern statue. The Temple is located on the Dafo Road, Rongxian, Zigong Shi, Sichuan Sheng, China. Dàfó (大佛) in Chinese means Big Buddha. The nearest city is Zigong.

Zigong
Zigong (Chinese: 自贡, tsih-kung), formed by the merger of the two former towns of Ziliujing (Tzuliuching, literally "self-flow well") and Gongjing (Kungching, literally "offering well"), is a prefecture-level city in Sichuan, Southwestern China.
Ivan Herceg (footballer)
Ivan Herceg (Croatian pronunciation: [ǐʋan xěrtseɡ]; born 10 February 1990 in Zagreb, SR Croatia, SFR Yugoslavia) is a Croatian professional footballer who currently plays for French club FCO Strasbourg Koenigshoffen 06.

Socialist Republic of Croatia
The Socialist Republic of Croatia (Serbo-Croatian: Socijalistička Republika Hrvatska), commonly abbreviated as SR Croatia and referred to as simply Croatia, was a constituent republic and federated state of the Socialist Federal Republic of Yugoslavia. By its constitution, modern-day Croatia is its direct continuation.

Along with five other Yugoslav republics, Croatia was formed during World War II and became a socialist republic after the war. It had four full official names during its 48-year existence (see below). By territory and population, it was the second largest republic in Yugoslavia, after the Socialist Republic of Serbia.

In 1990, the government dismantled the single-party system of government – installed by the League of Communists – and adopted a multi-party democracy. The newly elected government of Franjo Tuđman moved the republic towards independence, formally seceding from Yugoslavia in 1991 and thereby contributing to its dissolution.
Department of Agriculture (Sri Lanka)
The Department of Agriculture (DOA) functions under the Ministry of Agriculture of Government of Sri Lanka is one of the largest government departments with a high profile community of agricultural scientists and a network of institutions covering different agro ecological regions island wide. DOA  focuses on maintaining and increasing productivity and production of the food crops in the country. Two Agriculture parks functions under the department.

Government of Sri Lanka
The Government of Sri Lanka (GoSL) (Sinhala: ශ්‍රී ලංකා රජය, romanised: Śrī Laṅkā Rajaya; Tamil: இலங்கை அரசாங்கம், romanised: Ilaṇkai Aracāṅkam) is a semi-presidential republic determined by the Sri Lankan Constitution. It administers the island from both its commercial capital of Colombo and the administrative capital of Sri Jayawardenepura Kotte.
Pierre Monsan
Pierre Monsan (born June 25, 1948, in Prades, Pyrénées-Orientales, France) is a French biochemist and entrepreneur. He is currently Professor emeritus at the Institut national des sciences appliquées de Toulouse (INSA Toulouse, affiliated to the University of Toulouse) and the founding director of the pre-industrial demonstrator Toulouse White Biotechnology (TWB).

Monsan's scientific interests include biocatalysis, biochemical and enzyme engineering. Beyond his academic work, Monsan is co-inventor on numerous patents and co-founded several industrial biotechnology companies.

Prades, Pyrénées-Orientales
Prades (French: [pʁad]; Catalan: Prada de Conflent [ˈpɾaðə ðə kuɱˈflen]) is a commune and subprefecture of the Pyrénées-Orientales department in the Occitanie region of Southern France. Prades is the capital of the historical Conflent comarca. Its inhabitants are called Pradéens and Pradéennes in French and Pradencs and Pradenques in Catalan. It is also the hometown of Jean Castex, who served as Prime Minister of France from 2020 to 2022.
Linda Pagli
Linda Pagli (born 1950) is an Italian computer scientist specializing in computer networks and distributed algorithms. She is a professor at the University of Pisa, and a Fellow of the Italian Academy for Advanced Studies in America. She has also worked with UNESCO and the Italian Ministry of Foreign Affairs to help spread expertise in computer science to developing countries.

Casa Italiana
Casa Italiana is a building at Columbia University located at 1161 Amsterdam Avenue between West 116th and 118th Streets in the Morningside Heights neighborhood of Manhattan, New York City, which houses the university's Italian Academy for Advanced Studies in America. It was built in 1926–27 and was designed by William M. Kendall of McKim, Mead & White in the Renaissance style, modeled after a 15th-century Roman palazzo. The building was restored, and the east facade completed, in 1996 by Buttrick White & Burtis with Italo Rota as associate architect.
World Out of Mind!
World Out of Mind is also the title of a science fiction novel by J. T. McIntosh

World Out of Mind is a Man or Astro-man? 7-inch EP released on Estrus Records in 1995. It was released exclusively on clear yellow-orange vinyl. Art Chantry designed/illustrated the cover. The cover is die-cut, with a rounded top and 3 lightning bolts cut out.

Estrus Records
Estrus Records was an independent record label from Bellingham, Washington, that released surf, garage and "trash rock" music throughout the 1990s. The label was owned and operated by Dave Crider who played guitar in The Mono Men.
Goddess I
Goddess I is the Taube's Schellhas-Zimmermann letter designation for one of the most important Maya deities: a youthful woman to whom considerable parts of the post-Classic codices are dedicated, and who equally figures in Classic Period scenes. Based on her representation in codical almanacs, she is considered to represent vital functions of the fertile woman, and to preside over eroticism, human procreation, and marriage. Her aged form is associated with weaving. Goddess I could, perhaps, be seen as a terrestrial counterpart to the Maya moon goddess. In important respects, she corresponds to Xochiquetzal among the Aztecs, a deity with no apparent connection to the moon.

Bacab
Bacab (Mayan pronunciation: [ɓaˈkaɓ]) is the generic Yucatec Maya name for the four prehispanic aged deities of the interior of the Earth and its water deposits. The Bacabs have more recent counterparts in the lecherous, drunken old thunder deities of the Gulf Coast regions. The Bacabs are also referred to as Pawahtuns.
2015 Trofeo Faip–Perrel
The 2015 Trofeo Faip–Perrel was a professional tennis tournament played on hard courts. It was the tenth edition of the tournament which was part of the 2015 ATP Challenger Tour. It took place in Bergamo, Italy between 9 and 15 February 2015.

Benoît Paire
Benoît "Ben" Paire (French pronunciation: [bənwa pɛːʁ]; born 8 May 1989) is a French professional tennis player. He has a career-high singles ranking of World No. 18, achieved in January 2016.

He has won three singles titles, at the 2015 Swedish Open, the 2019 Marrakesh Open and the 2019 Lyon Open. His best result in a Grand Slam has been reaching the fourth round on four occasions. He has a career-high ranking of World No. 65 in doubles achieved on 15 November 2021.

In 2015, Paire was voted Comeback Player of the Year, rising from world No. 118 ATP singles ranking at year-end 2014 to a then career-high world No. 19 at year-end 2015, after a knee injury had sidelined him for much of 2014.
The Darkest Skies Are the Brightest
The Darkest Skies Are the Brightest is the third solo studio album by Anneke van Giersbergen, released on 26 February 2021 by Inside Out Music. It was written entirely by van Giersbergen and produced by Gijs Coolen.

Inside Out Music
InsideOutMusic is a progressive rock record label originally based in Kleve, North Rhine-Westphalia, dedicated to releasing progressive rock, progressive metal and related styles. In 2009, it formed a partnership with Century Media Records and moved its base of operations to Dortmund, also in North Rhine-Westphalia. In August 2016, Century Media and InsideOutMusic were acquired by Sony Music Entertainment and moved their operations to Berlin.
Calatrava la Nueva
Calatrava la Nueva (Sacro convento-castillo de Calatrava la Nueva) is a medieval castle and convent found on the peak of Alacranejo, within the municipality of Aldea del Rey, near Almagro, in the province of Ciudad Real, Spain.

Its name is a reference to the Order of Calatrava, which was originally situated in Calatrava la Vieja, 60 km to the north.  In 1217, the Order of Calatrava moved to Calatrava la Nueva.  Thus, the original site became known as Calatrava la Vieja ("Old Calatrava") and the new site as Calatrava la Nueva ("New Calatrava").

Almagro, Ciudad Real
Almagro (Spanish pronunciation: [alˈmaɣɾo]) is a town and municipality situated in Ciudad Real province, in the autonomous community of Castile-La Mancha, Spain. A tourist destination, Almagro is designated a Conjunto histórico, a type of conservation area.

Almagro lies within small Paleozoic mountain ranges, with some reserves of shallow creeks, including the Pellejero and de Cuetos. It also lies within a volcanic zone (Cerro de la Yezosa), which lies upon a quartzite massif. It makes the zone particularly unique, together with that of the zones of Olot and Cabo de Gata, in the sense that it is one of the few important zones of volcanic origin in the Iberian Peninsula. An International Festival of Classical Theater has also been celebrated here annually since 1978.
A Private Affair (2002 film)
A Private Affair (French: Une affaire privée) is a 2002 French crime mystery thriller film written and directed by Guillaume Nicloux. The film premiered at the Festival du Film Policier de Cognac on 13 April 2002 and was released theatrically in France on 30 April 2002.

Festival du Film Policier de Cognac
The Festival du Film policier de Cognac (English: Cognac Crime Film Festival), also known as Cognac Festival du Film Policier, was an annual film festival that took place in Cognac, France from 1982 to 2007.
Alliance for Mexico
The Alliance for Mexico (Spanish: Alianza por México) is the name of two multi-party electoral alliances in Mexico, one from 2000 and the other from 2006.

In the 2000 general election, Alliance for Mexico was a grouping of the Party of the Democratic Revolution, the Labor Party, the Party of the Nationalist Society, Convergence for the Democracy (founded by ex-PRI dissidents) and the Social Alliance Party (founded by precursors of the Mexican Democratic Party). Cuauhtémoc Cárdenas ran as its candidate for president of Mexico and won 19 percent of the vote. The Alliance also won 68 seats in the Chamber of Deputies and 17 seats in the Senate.

Cuauhtémoc Cárdenas
Cuauhtémoc Cárdenas Solórzano (Spanish pronunciation: [kwawˈtemok ˈkaɾðenas]; born 1 May 1934) is a Mexican politician and civil engineer. A prominent social-democrat and the son of 51st president of Mexico Lázaro Cárdenas, he is a former Head of Government of Mexico City and a founder of the Party of the Democratic Revolution (PRD). He ran for the presidency of Mexico three times, and his loss in the 1988 Mexican general election to Institutional Revolutionary Party (PRI) candidate Carlos Salinas de Gortari had long been considered the result of electoral fraud perpetrated by the ruling PRI, later acknowledged by Miguel de la Madrid, the incumbent president at the time of the election. He previously served as a Senator, having been elected in 1976 to represent the state of Michoacán and also as the Governor of Michoacán from 1980 to 1986.
Scouting on the Isle of Man
Scouting in the Isle of Man is represented by the Scout Association of the United Kingdom. The Scout Association's Island Headquarters are at Cunningham House in Douglas. The association has its own campsite, Mullin ny Carty. Some of the Groups also have their own bunkhouses or campsites, in addition to their own headquarters.

The Scout Association's Patron is the Lieutenant Governor, Sir John Lorimer, and its President is the former Chief Minister, Sir Miles Walker.

John Lorimer (British Army officer)
Sir John Gordon Lorimer is a retired senior British Army officer, who served as the Chief of Joint Operations and the Defence Senior Adviser to the Middle East and North Africa. He was appointed Lieutenant Governor of the Isle of Man on 29 September 2021.
Abraham Lincoln (1924 film)
The Dramatic Life of Abraham Lincoln is a 1924 American silent historical drama film directed by Phil Rosen and written by Frances Marion. By the date of release, the film's title was shortened to Abraham Lincoln, since the previous title was regarded as cumbersome.

Phil Rosen
Philip E. Rosen (May 8, 1888 – October 22, 1951) was an American film director and cinematographer. He directed more than 140 films between 1915 and 1949.

He was born in Marienburg, German Empire (now, Malbork, Poland), grew up in Machias, Maine, and died in Hollywood, California, of a heart attack. He was one of the founders of the American Society of Cinematographers. Rosen was married to model and actress Joyzelle Joyner.

Rosen was meant to direct The Mad Dog of Europe, a film written by Herman J. Mankiewicz with Rudolph Hitler as its central character, but the film was never made.
Mario Bortolotto
Mario Bortolotto (26 June 1957 – 9 September 2022) was an Australian rules footballer who played with Geelong and Carlton in the VFL.

Bortolotto played as a defender and started his career at Geelong. He was delisted after two seasons and crossed to Carlton with whom he would be a premiership player in 1981 and 1982.

1981 VFL grand final
The 1981 VFL Grand Final was an Australian rules football game contested between the   Carlton Football Club and Collingwood Football Club, held at the Melbourne Cricket Ground in Melbourne on  26 September 1981. It was the 85th annual Grand Final of the Victorian Football League, staged to determine the premiers for the 1981 VFL season. The match, attended by 112,964 spectators, was won by Carlton by a margin of 20 points, marking that club's 13th premiership victory. This match as of 2025 is the last one where these two great rivals clashed in a grand final.
Cedar Rapids RoughRiders
The Cedar Rapids RoughRiders are a Tier I junior ice hockey team playing in the United States Hockey League (USHL). Before moving to Cedar Rapids, Iowa, in 1999, the team was based in Mason City, where they were known as the North Iowa Huskies.

The RoughRiders' home ice is the ImOn Ice Arena also known as The Stable.

Mason City, Iowa
Mason City is a city in and the county seat of Cerro Gordo County, Iowa, United States. The population was 27,338 in the 2020 census. Mason City is known for its musical and masonry heritage, as well as being home to a significant collection of Prairie School style architecture. The city forms a regional commercial, industrial, and cultural hub for north-central Iowa with nearby Clear Lake.

The Mason City Micropolitan Statistical Area that includes all of Cerro Gordo and Worth counties is located at the transportation junction between Interstate 35 and the Avenue of the Saints. Local public education is provided by North Iowa Area Community College and Mason City Community School District. The Winnebago River traverses the community to the southeast.
Saint-Antoine-de-Breuilh
Saint-Antoine-de-Breuilh (French pronunciation: [sɛ̃.t‿ɑ̃twan də bʁœj]; Occitan: Sent Antòni del Bruèlh) is a commune in the Dordogne department in Nouvelle-Aquitaine in southwestern France, in the urban unit of Bergerac. It was created in 1824 with the fusion of Saint-Aulaye and Le Breuilh. Saint-Antoine-de-Breuilh station has rail connections to Bordeaux, Bergerac and Sarlat-la-Canéda.

Dordogne
Dordogne (UK: /dɔːrˈdɔɪn/ dor-DOYN, US: /dɔːrˈdoʊn/ dor-DOHN or /dɔːrˈdɔːnjə/ dor-DAWN-yə; French: [dɔʁdɔɲ] ⓘ; Occitan: Dordonha [duɾˈduɲɔ]) is a large rural department in southwest France, with its prefecture in Périgueux. Located in the Nouvelle-Aquitaine region roughly half-way between the Loire Valley and the Pyrenees, it is named after the river Dordogne, which runs through it. It corresponds roughly to the ancient county of Périgord. In January 2023, Dordogne had a population of 412,807.
Tyler Gonzalez
Tyler Gonzalez (born 19 July 2004) is an American and Spanish racing driver competing for BSI Racing in the Mazda MX-5 Cup, Victor Gonzalez Racing Team in Michelin Pilot Challenge and RAFA Racing Team in GT4 America Series. He also competes part-time in the NASCAR O'Reilly Auto Parts Series, driving the No. 5 Ford Mustang Dark Horse for Hettinger Racing.

Sebring International Raceway
Sebring International Raceway is a road course auto racing facility in the southeastern United States, located near Sebring, Florida.

Sebring Raceway is one of the oldest continuously operating race tracks in the U.S., its first race being run in 1950. Sebring is one of the classic race tracks in North American sports car racing, and plays host to the 12 Hours of Sebring.

The raceway occupies a portion of Sebring Regional Airport (an active airport for private and commercial traffic that was originally built as Hendricks Army Airfield, which was a World War II training base for the United States Army Air Forces).
Drenica
Drenica (Albanian indefinite form: Drenicë, Serbian Cyrillic: Дреница), also known as the Drenica Valley, is a hilly region in central Kosovo, covering roughly around 700 square kilometres (270 sq mi) of Kosovo's total area (6%). It consists of two municipalities, Drenas and Skenderaj, and several villages in Klina, Zubin Potok, Mitrovica and Vushtrri. It is located west of the capital, Pristina.

According to the 2011 Census, the population of the region is 109,389, excluding the surrounding villages. Albanians form the absolute majority of the region.

Kosovo Albanians
The Albanians of Kosovo (Albanian: Shqiptarët e Kosovës, pronounced [ʃcipˈtaɾət ɛ kɔˈsɔvəs]), commonly also called Kosovo Albanians, Kosovan Albanians or Kosovar Albanians,  are an ethnic Albanian population native to Kosovo and constitute the country's largest ethnic group. They belong to the Gheg dialectical sub-group of Albanians, because they speak Gheg Albanian. According to the 2024 national census by the ASK, Albanians comprise 91.8% of the population in Kosovo.