hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Cediranib
Cediranib (AZD-2171; tentative trade name Recentin) is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases.

The drug is being developed by AstraZeneca as a possible anti-cancer chemotherapeutic agent for oral administration.

Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to the tyrosine residues of specific proteins inside a cell. It functions as an "on" or "off" switch in many cellular functions.

Tyrosine kinases belong to a larger class of enzymes known as protein kinases which also attach phosphates to other amino acids such as serine and threonine. Phosphorylation of proteins by kinases is an important mechanism for communicating signals within a cell (signal transduction) and regulating cellular activity, such as cell division.

Protein kinases can become mutated, stuck in the "on" position, and cause unregulated growth of the cell, which is a necessary step for the development of cancer. Therefore, kinase inhibitors, such as imatinib and osimertinib, are often effective cancer treatments.

Most tyrosine kinases have an associated protein tyrosine phosphatase, which removes the phosphate group.
Oakland Activities Association
Oakland Activities Association is a Southeast Michigan high school athletics conference. It is made up of 23 schools located largely throughout Oakland County, with a single member located in Wayne County

Oakland County, Michigan
Oakland County is a county in the U.S. state of Michigan. It is a principal county of the Detroit metropolitan area, containing the bulk of Detroit's northern suburbs. Its county seat is Pontiac, and its largest city is Troy. As of the 2020 census, its population 1,274,395, making it the second-most populous county in Michigan (behind neighboring Wayne County), and the most populous county in the United States without a city of 100,000 residents.

Founded in 1819 and organized the following year, Oakland County is composed of 62 cities, villages, and townships. In 2010, Oakland County was among the ten wealthiest counties in the United States to have over one million residents. It is also home to Oakland University, a large public institution that straddles the border between the cities of Auburn Hills and Rochester Hills.
The Wonder Weeks
The Wonder Weeks: A Stress-Free Guide to Your Baby's Behavior is a book with advice to parents about child development by physical anthropologist Hetty van de Rijt and ethologist and developmental psychologist Frans Plooij. Their daughter Xaviera Plas-Plooij is a third author of recent editions. It was first published in English in 2003 as the translation of the 1992 Dutch book Oei, ik groei! The book claims that the cognitive development of babies occurs in predictably timed stages. Ever since the systematic study of child development began at the beginning of the 20th century researchers have disagreed whether this is gradual or in punctuated stages. Some figures in the child development field have objected that sleep regressions are not so predictable. A chapter on sleep was added to the 6th edition in 2019. The publisher has produced a mobile app based on the book.

Biological anthropology
Biological anthropology, also known as physical anthropology, is a natural science discipline concerned with the biological and behavioral aspects of human beings, their extinct hominin ancestors, and related non-human primates, particularly from an evolutionary perspective. This subfield of anthropology systematically studies human beings from a biological perspective.
Jan Roberts
Jan Roberts Baloloy is a Filipino singer-songwriter and guitarist from Albay. He started sharing his music during the COVID-19 pandemic through online busking on social media platforms. His 2024 single "Sagip" (transl. Save) charted on Spotify Philippines' Viral 100. He is currently signed under Warner Music Philippines.

Albay
Albay (IPA: [ɐlˈbaɪ]),  officially the Province of Albay (Central Bikol: Probinsya kan Albay; Tagalog: Lalawigan ng Albay) is a province in the Bicol Region of the Philippines, mostly on the southeastern part of the island of Luzon. Its capital (and largest city) is the city of Legazpi, the regional center of the whole Bicol Region, which is located in the southern foothill of Mayon Volcano.

The province was added to the UNESCO World Network of Biosphere Reserves in March 2016.
Terry Garland
Terry Ray Garland (June 3, 1953 – September 19, 2021), who was born in Johnson City, Tennessee, was an American blues guitarist, songwriter and singer. The Allmusic journalist Niles J. Frantz wrote that Garland was "a country blues interpreter who plays a National steel guitar, often with a slide, in the style of Bukka White and Fred McDowell."

National String Instrument Corporation
The National String Instrument Corporation was an American guitar company first formed to manufacture banjos and then the original resonator guitars. National also produced resonator ukuleles and resonator mandolins. The company merged with Dobro to form the "National Dobro Company", then becoming a brand of Valco until it closed in 1968.
Ludwig Berger (director)
Ludwig Berger (born Ludwig Bamberger; 6 January 1892 – 18 May 1969) was a German-Jewish film director, screenwriter and theatre director. He directed more than 30 films between 1920 and 1969. Berger began working in the German film industry during the Weimar Republic. At Decla-Bioscop and later UFA he established a reputation as a leading director of silent films. He emigrated to Hollywood, but was unable to establish himself and returned to Europe. He subsequently worked both in France and Germany. He was a member of the jury at the 6th Berlin International Film Festival.

Berger also translated a few plays of Shakespeare, including Cymbeline, Hamlet, and Timon of Athens. His elder brother was the set designer Rudolf Bamberger who was killed in 1945.

Timon of Athens
The Life of Tymon of Athens, often shortened to Timon of Athens, is a play written by William Shakespeare and likely also Thomas Middleton in about 1606. It was published in the First Folio in 1623. Timon lavishes his wealth on parasitic companions until he is poor and rejected by them. He then denounces all of mankind, and isolates himself in a cave in the wilderness.

The earliest-known production of the play was in 1674, when Thomas Shadwell wrote an adaptation under the title The History of Timon of Athens, The Man-hater. Multiple other adaptations followed over the next century, by writers such as Thomas Hull, James Love and Richard Cumberland.
The straight Shakespearean text was performed at Smock Alley in Dublin in 1761, but adaptations continued to dominate the stage until well into the 20th century.

Timon of Athens was originally grouped with the tragedies, but recently some scholars name it as one of the problem plays.
The Wiser Sex
The Wiser Sex is a 1932 American pre-Code crime drama film directed by Berthold Viertel and Victor Viertel and starring Claudette Colbert, Melvyn Douglas, Lilyan Tashman, William "Stage" Boyd and Ross Alexander. Made by Paramount Pictures, its working title was The Weaker Sex.

Clyde Fitch's play was first filmed by Famous Players' in 1916 as The Woman in the Case, directed by Hugh Ford and starring Pauline Frederick. Famous Players–Lasky's 1922 production, The Law and the Woman, directed by Penrhyn Stanlaws and starring Betty Compson, was also based on Fitch's play.

It is the film debut of Franchot Tone and the final film of stage veteran Effie Shannon.

Betty Compson
Betty Compson (born Eleanor Luicime Compson; March 19, 1897 – April 18, 1974) was an American actress and film producer who got her start during Hollywood's silent era. She is best known for her performances in The Docks of New York and The Barker, the latter of which earned her an Academy Award nomination for Best Actress.
Sicilian vowel system
The Sicilian vowel system is characteristic of the dialects of Sicily, Southern Calabria, Cilento and Salento.  It may alternatively be referred to as the Sicilian vocalic scheme  or the Calabro-Sicilian vowel system.

The Sicilian vowel system differs greatly from the evolution of the Classical Latin vowel system into the Vulgar Latin vowel system found in the greater part of the Romance area. In this system, there was a lowering (laxing) of short /i/, /e/, /o/, and /u/ into a seven-vowel system, while in the development of the Sicilian vowel system from that of Classical Latin, long /eː/ was raised to [i] and fused with both quantities of /i/; short /e/ was lowered to [ɛ] with an analogous development with the round vowels; i.e. long /oː/ was raised to [u] and fused with both quantities of [u]; short /o/ was lowered to [ɔ].  This resulted in a five-vowel system.

Close back rounded vowel
The close back rounded vowel, or high back rounded vowel, is a type of vowel sound used in many spoken languages. The symbol in the International Phonetic Alphabet that represents this sound is ⟨u⟩.

In most languages, this rounded vowel is pronounced with protruded lips ('endolabial'). However, in a few cases the lips are compressed ('exolabial').

[u] alternates with labio-velar approximant [w] in certain languages, such as French, and in the diphthongs of some languages, [u̯] with the non-syllabic diacritic and [w] are used in different transcription systems to represent the same sound.
Igor Velichkin
Igor Velichkin (born 3 July 1987) is a Russian professional ice hockey forward. He is currently player of HC 19 Humenné who most recently played for Amur Khabarovsk of the Kontinental Hockey League (KHL).

Velichkin made his KHL debut with Traktor Chelyabinsk during the inaugural 2008–09 KHL season.

Amur Khabarovsk
Hockey Club Amur (Russian: Хоккейный клуб Амур), commonly referred to as the Amur Khabarovsk, is a professional ice hockey club based in Khabarovsk, Russia. It is a member of the Chernyshev Division in the Kontinental Hockey League (KHL). Located in the Russian Far East, the team takes its name from the Amur River, and plays its home games at the Platinum Arena.
UDESCAI
UDESCAI (União Desportiva Sardinha e Caça de Água-Izé) is a football club that plays in the São Tomé and Príncipe Championship.  The team is based in the town of Água Izé in island of São Tomé and plays in Campo de Futebol de Santana in the north, it once played in Pantufo at Campo de Pantufo.

São Tomé (island)
São Tomé, at 854 km2 (330 sq mi), is the largest island of São Tomé and Príncipe and is home in May 2018 to about 193,380 or 96% of the nation's population. The island is divided into six districts. It is located 2 km (1¼ miles) north of the equator.
Diocese of Budapest and Hungary
The Diocese of Budapest and Hungary (Russian: Будапештская и Венгерская епархия, Hungarian: Budapesti-Magyar Egyházmegye, also: Hungarian Orthodox Diocese, Hungarian: Magyar Orthodox Egyházmegye, or Hungarian Diocese, Hungarian: Magyar Egyházmegye) is diocese of the Russian Orthodox Church, unites parishes in Hungary.

Nyíregyháza
Nyíregyháza (Hungarian: [ˈɲiːrɛchaːzɒ] ⓘ, Slovak: Níreďháza [ˈɲiːrɛɟɦaːza]) is a city with county rights in northeastern Hungary and the county capital of Szabolcs-Szatmár-Bereg. With a population of 118,001, it is the seventh-largest city in Hungary and the second largest in the Northern Great Plain region. Its development has been ongoing since the 18th century, making it the economic and cultural center of the region. Nyíregyháza Zoo, with over 500 species, is recognized throughout Europe.
Çavuştepe
Sardurihinilli, also known as Haykaberd (Armenian: Հայկաբերդ, lit. 'Fortress of Hayk') or Çavuştepe Kalesi, is an ancient Urartian fortified site located on a ridge on the northeastern edge of the village of Çavuştepe in the Gürpınar district of Van Province in eastern Turkey. It is located approximately 25 kilometers southeast of Van along the road leading to the city of Hakkâri, in a valley once known as Hayots Dzor in historic Armenia. It was founded by the Urartian king Sarduri II (r. 764–735) some time during his reign in the 8th century BC and is believed to be identical with the fortress of Sardurihurda mentioned in the same king's cuneiform inscriptions.

In Armenian folklore it is identified with Haykaberd or Haykʻ, the fortress built by Hayk, the legendary founder of the Armenian nation, close to the site where he slew the invading Babylonian king Bel.

Hakkâri (city)
Hakkâri (Turkish pronunciation: [hacːaːɾi]), formerly known as Julamerk, (Turkish: Çölemerik, Kurdish: Colemêrg, Armenian: Ջղմար, romanized: Jghmar) is a city and the seat of Hakkâri District in the Hakkâri Province of Turkey. The city is populated by Kurds and had a population of 58,470 in 2023.

It is located about 40 km (25 mi) from the Iraq–Turkey border, but the distance to the nearest Iraqi border crossing (Ibrahim Khalil border crossing) by road is about 270 km (170 mi)
Benson Jack Anthony
Benson Jack Anthony is an Australian actor. For his performance in 800 Words he was nominated for the 2016 Logie Award for Best New Talent.

Anthony played Arlo Turner, a lead character in the family drama 800 Words, set in a beachside town in New Zealand. In 2016 he starred as Ethan in Emo the Musical and featured in 2019's Awoken. He voices the character Willy, Maya's best friend, in Maya the Bee: The Honey Games  and Maya the Bee: The Golden Orb.

In 2019, Anthony filmed Fam Time for Channel 7 but the project was shelved until 2024 where it aired on Channel 7's streaming service 7plus on 11 July 2024.

Logie Awards of 2016
The 58th Annual TV Week Logie Awards were held on Sunday 8 May 2016 at the Crown Palladium in Melbourne, and broadcast live on the Nine Network. Public voting for the Best Award categories began on 16 November 2015, and ended on 17 January 2016. Nominations were announced on 3 April 2016, along with the winners of the Outstanding Newcomer Awards.

It was announced on 4 November 2015, that the 2016 Logie Awards would reinstate the Logie Award for Best Factual Program, as well as a new publicly voted category for Best News Panel or a Current Affairs Program. Two new industry-voted awards were also given, Logie Award for Most Outstanding Supporting Actor and Actress. Additionally, all publicly voted category awards changed their title from "Most Popular" to "Best" awards.
Cross Lake (Temagami)
Cross Lake is a lake in Temagami, Nipissing District, Ontario, Canada, about 20 kilometres (12 mi) southwest of the centre of that community. The lake has fish inhabits of walleye, smallmouth bass and northern pike.

Smallmouth bass
The smallmouth bass (Micropterus dolomieu) is a species of freshwater fish in the sunfish family (Centrarchidae) of the order Centrarchiformes. It is the type species of its genus Micropterus (black basses), and is a popular game fish sought by anglers throughout the temperate zones of North America, and has been spread by stocking —as well as illegal introductions—to many cool-water tributaries and lakes in Canada and more so introduced in the United States. The maximum recorded size is approximately 27 inches (69 cm) and 12 pounds (5.4 kg).

The smallmouth bass is native to the upper and middle Mississippi River basin, the Saint Lawrence River–Great Lakes system, the Champlain Valley, and the Hudson Bay basin. Its common names include smallmouth, bronzeback, brown bass, brownie, smallie, bronze bass, and bareback bass.
Espresso martini
The espresso martini, also known as a vodka espresso, is a cold caffeinated alcoholic drink made with espresso, coffee liqueur, and vodka. It is not a true martini as it contains neither gin nor vermouth, but is one of many drinks that incorporate the term martini into their names.

Caffeinated alcoholic drink
A caffeinated alcoholic drink is a drink that contains both alcohol (also known formally as ethanol) and a significant amount of caffeine. Caffeine, a stimulant, masks some of the depressant effects of alcohol.
In 2010 and 2011, this type of drink faced criticism for posing health risks to its drinkers. In some places there is a ban on caffeinated alcoholic drinks.

Sometimes, caffeinated alcoholic drinks are made by mixing existing caffeinated drinks (coffee, energy drinks, cola) with alcoholic drinks.
2020 Menards.com 200
The 2020 Menards.com 200 Presented by SPxE was the ninth stock car race of the 2020 ARCA Menards Series, the fourth race of the 2020 Sioux Chief Showdown, and the first of two back-to-back races of the weekend. The race was held on Friday, July 31, 2020,  in Toledo, Ohio, at Toledo Speedway, a 0.5 miles (0.80 km) permanent oval-shaped racetrack. The race took the scheduled 200 laps to complete. At race's end, Sam Mayer of GMS Racing would dominate the late stages of the race to win his first career ARCA Menards Series win and his first win of the season. To fill out the podium, Ty Gibbs of Joe Gibbs Racing and Taylor Gray of DGR-Crosley would finish second and third, respectively.

Tricon Garage
Tricon Garage (stylized as TRICON Garage), formerly known as David Gilliland Racing, DGR-Crosley, and Team DGR, is an American professional stock car racing team that competes in the NASCAR Craftsman Truck Series and the NASCAR Cup Series. The team was founded in early 2017 when racing team owners David Gilliland and Bo LeMastus came together to form a collaborative effort from their respective teams, David Gilliland Racing and Crosley Sports Group, known as DGR-Crosley. DGR-Crosley fielded Toyotas in 2018 and 2019 before announcing its switch to Ford starting in 2020. The team reverted to the David Gilliland Racing name in 2021 as Johnny Gray became a co-owner. Former co-owner and driver Bo LeMastus remained with the team in a marketing and sponsorship capacity.

On October 27, 2022, the team announced that they would be returning to Toyota Racing Development in 2023 and would rename the team Tricon Garage. The new name is said to be derived from the prefix tri- and the word icon.
James A. Wells
James Allen Wells (born April 28, 1950) is a Professor of Pharmaceutical Chemistry and Cellular & Molecular Pharmacology at the University of California, San Francisco (UCSF) and a member of the National Academy of Sciences. He received his B.A. degrees in biochemistry and psychology from University of California, Berkeley in 1973 and a PhD in biochemistry from Washington State University with Ralph Yount in 1979. He completed his postdoctoral studies at Stanford University School of Medicine with George Stark in 1982. He is a pioneer in protein engineering, phage display, fragment-based lead discovery, cellular apoptosis, and the cell surface proteome.

Stanford University School of Medicine
The Stanford University School of Medicine is the medical school of Stanford University and is located in Stanford, California, United States. It traces its roots to the Medical Department of the University of the Pacific, founded in San Francisco in 1858. This medical institution, then called Cooper Medical College, was acquired by Stanford in 1908. In 1959, the medical school moved to the Stanford campus near Palo Alto, California.

The School of Medicine, along with Stanford Health Care and Lucile Packard Children's Hospital, is part of Stanford Medicine.
Bert Clay
Albert Henry Clay (7 May 1915 – 30 April 1972) was an Australian rules footballer who played for Fitzroy in the Victorian Football League (VFL). His twin brother Ivor also played with him in the Fitzroy side.

In 1939, Bert and his identical twin brother, Ivor trained with North Melbourne under coach, Keith Forbes, but both missed out on the being selected in the final list and returned to Henty, NSW.

Originally from the Hunter Football Club in the Lockington Football Association, Bert was recruited from Henty, where he played in their 1937 premiership and was runner up in the 1938 Albury & District Football League's best and fairest award (lost on a count back) then won the 1939 award. Clay played in Henty's losing 1939 grand final side against Brocklesby.

Clay played as a ruckman and was instrumental in the club's 1944 Grand Final victory, rated by his opponent Jack Dyer as the best on ground.

Clay retired from VFL football at 36 years of age, after 152 games.

1944 VFL grand final
The 1944 VFL Grand Final was an Australian rules football game contested between the Fitzroy Football Club and Richmond Football Club, held at the Junction Oval in Melbourne on 30 September 1944. It was the 46th annual grand final of the Victorian Football League, staged to determine the premiers for the 1944 VFL season.

The match was won by Fitzroy by a margin of 15 points, marking that club's first premiership since 1922, and its eighth (and final) premiership and final grand final appearance. The match attracted 41,000 spectators, down on expectations owing in part to a one-day tram strike.

This was Fitzroy's last VFL premiership before they merged with the Brisbane Bears in 1997 to become the Brisbane Lions. Fitzroy did not win another senior premiership or contest another grand final throughout its time in the VFL/AFL.
Custom House, Bristol
The Custom House in Bristol was the building formally used for collecting customs duties on foreign trade when entering or leaving the port. The location of this building within Bristol varied over the centuries. The building now known as the 'Custom House' dates from 1836 and is located on Queen Square. Goods are no longer declared in the city itself, since the Port of Bristol has now moved entirely down to Avonmouth Docks, on the Severn Estuary.

Customs
Customs is an authority or agency in a country responsible for collecting tariffs and for controlling the flow of goods, including animals, transports, personal effects, and hazardous items, into and out of a country. Traditionally, customs has been considered as the fiscal subject that charges customs duties (i.e. tariffs) and other taxes on import and export. In recent decades, the views on the functions of customs have considerably expanded and now covers three basic issues: taxation, security, and trade facilitation.

Each country has its own laws and regulations for the import and export of goods into and out of a country, enforced by their respective customs authorities; the import/export of some goods may be restricted or forbidden entirely. A wide range of penalties are faced by those who break these laws.
Gateway Marketplace
Gateway Marketplace is a power center in Detroit, Michigan. The complex is located at the southeast corner of 8 Mile Road (M-102) and Woodward Avenue (M-1), adjacent to the Jason Hargrove Transit Center and near the former site of the Michigan State Fair complex. The complex contains around forty inline tenants on its 35 acres (140,000 m2).

Michigan State Fair
The Michigan State Fair is an annual event originally held from 1849 to 2009 in Detroit, the state's largest city. In 2009 the governor declined to fund it because of other priorities.

Because agriculture still has a major place in the Michigan economy, in 2011 supporters organized the Great Lakes Agricultural Fair, a 501 C (3) organization, in order to continue the event. Since 2013 it has been organized by the private Michigan State Fair LLC and held in the Suburban Collection Showplace in the Metro Detroit suburb of Novi.
2007–08 PBA Philippine Cup
The 2007–08 Philippine Basketball Association (PBA) Philippine Cup or known as the 2007–08 Smart PBA Philippine Cup for sponsorship reasons, was the first conference of the 2007–08 PBA season. The tournament was formally opened on October 14, 2007, and ended on March 2, 2008. The tournament is an All-Filipino format, which doesn't require an import or a pure-foreign player for each team.

The winner will receive the Jun Bernardino Trophy. The Sta. Lucia Realtors needed the maximum seven games to defeat the #1 seed Purefoods Tender Juicy Giants to win their first All-Filipino conference championship.

Sponsor (commercial)
Sponsoring something (or someone) is the act of supporting an event, activity, person, or organization financially or through the provision of products or services. The individual or group that provides the support, similar to a benefactor, is known as the sponsor.