hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Flavokavain A
Flavokavain A is a flavokavain found in the kava plant.

A systematic review of studies on kava found evidence that its bioactive compounds, particularly flavokavain A and B, exert antiproliferative and pro-apoptotic effects across multiple cancer models, highlighting its potential chemotherapeutic use especially for epithelial cancers, though research on oral squamous cell carcinoma remains scarce. It shows strong anticancer effects—particularly against bladder cancer—by inducing apoptosis through Bax-dependent pathways and inhibiting key anti-apoptotic proteins, with promising results in both cell cultures and animal models.

Kava alone is not hepatotoxic in mice, but its chalcone compounds flavokavains A and B significantly increase acetaminophen-induced liver toxicity, suggesting that herb-drug interactions may explain rare severe liver damage seen with kava use in humans.

Carcinoma
Carcinoma is a malignancy that develops from epithelial cells. Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that arises from cells originating in the endodermal, mesodermal or ectodermal germ layer during embryogenesis.

Carcinomas occur when the DNA of a cell is damaged or altered and the cell begins to grow uncontrollably and becomes malignant.

The word is derived from the Greek: καρκίνωμα, romanized: karkinoma, lit. 'sore, ulcer, cancer' (itself derived from karkinos meaning crab).
Kōichirō Uno
Kōichirō Uno (宇能鴻一郎, Uno Kōichirō, b. July 25, 1934) is a Japanese author of erotic novels. His works have often been filmed, most notably by Nikkatsu studio in a prolific series of Roman Pornos giving the author's name in the title. He also won the Akutagawa Prize for Kujiragami (鯨神).

Akutagawa Prize
The Akutagawa Prize (芥川龍之介賞, Akutagawa Ryūnosuke Shō) is a Japanese literary award presented semi-annually. Because of its prestige and the considerable attention the winner receives from the media, it is, along with the Naoki Prize, one of Japan's most sought after literary prizes.
No More Lonely Nights
"No More Lonely Nights" is a song written and performed by the English musician Paul McCartney, first released on 24 September 1984, it was included on McCartney's fifth solo studio album Give My Regards to Broad Street.

The song features David Gilmour from Pink Floyd on guitars including the soaring solos and fills throughout the song. Reflecting upon the recording in a radio interview prior to 1990's Knebworth concerts, Gilmour told Jim Ladd that "No More Lonely Nights" was the last thing McCartney recorded for the film Give My Regards to Broad Street (late 1983/early 1984), and that he told McCartney to give his session fee to a charity of his choice.

Jim Ladd
James William Ladd (January 17, 1948 – December 17, 2023) was an American disc jockey (DJ), radio producer and writer. He was one of the last notable remaining free-form rock DJs in United States commercial radio.

Ladd first gained national prominence as host of the hour long nationally syndicated radio program Innerview, which aired weekly on over 160 stations nationwide for twelve years.
UPSAT
UPSAT is a private higher education institution located in Tunis, Tunisia. Part of the Honoris United Universities network since 2018, UPSAT is also present in Sousse and Sfax.

The institute offers courses in the field of healthcare.

Sfax
Sfax (/s(ə)ˈfæks/ s(ə-)FAKS; Arabic: صفاقس, romanized: Ṣafāqis, Tunisian Arabic: [ˈsˤfaːqəs] ⓘ) is a major port city in Tunisia, located 270 km (170 mi) southeast of Tunis. The city, founded in AD 849 on the ruins of Taparura, is the capital of the Sfax Governorate (about 955,421 inhabitants in 2014), and a Mediterranean port. Sfax has a population of 341,999 (census 2022). Its main industries include phosphate, olive and nut processing, fishing (it is the largest fishing port in Tunisia) and international trade. The city is the second-most populous in the country after the capital, Tunis.
Justin J. Pearson
Justin Jamal Pearson (PEER-sən; born January 7, 1995) is an American activist and politician. He is a member of the Tennessee House of Representatives representing the 86th district, covering parts of the city of Memphis. He was elected in a January 2023 special election to succeed Barbara Cooper, who was posthumously re-elected in the November 2022 Tennessee House of Representatives election after dying in October 2022. When he was sworn into office at the age of 28, Pearson became the third youngest lawmaker serving in the Tennessee House of Representatives.

He and fellow state representative Justin Jones were expelled in April 2023, for violating decorum rules by participating in a gun control protest on the House floor. He was reappointed by a unanimous vote of the members present at the Shelby County Board of Commissioners.

Pearson is currently challenging incumbent U.S. Representative Steve Cohen in the Democratic primary for Tennessee's 9th congressional district in 2026.

2022 Tennessee House of Representatives election
The 2022 Tennessee House of Representatives election was held on November 8, 2022, to elect 99 seats for the Tennessee House of Representatives. The elections coincided with the governor, U.S. House, and State Senate elections.

In District 41, longtime Democratic incumbent John Windle filed to run as an independent after representing the district for nearly three decades; he was known for his support of Second Amendment rights, and reporting noted that Democratic Party leaders had considered removing him from the Democratic primary ballot because his positions were out of step with party leadership, prompting his decision to run as an independent. Windle was defeated by Republican Ed Butler in the general election.

Republicans gained two seats, thereby further expanding their supermajority in the state house.
Mohamed Hassan Xaad
Nabadoon Maxamed Xasan Xaad (born 1940) better known as Nabadoon Xaad is the current chairman of the elders council of the Hawiye Somali clan family. He hails from the Mursall K. (Karanle) clan, subclan Habar Cayno.

Karanle
The Karanle (Arabic: كرنلي ,كرن, Somali: Karanle Oromo: Karala/Harala) are a Somali clan, forming one of the six branches of the larger Hawiye clan. The Karanle are geographically spread out across the countries: Somalia Ethiopia, and Kenya. Among all of the Karanle inhabited regions of the Horn of Africa, Ethiopia is where the majority of the clan reside. In Ethiopia, the Karanle are mainly found in Harar/Hararghe, Bale, and Babile but they also inhabit the Somali Region, Dir Dhaba and surrounding regions. The majority of the Karanle sub-clans predominantly reside in the regions of Ethiopia where the Somali population is predominant, with the exception of the Murusade Sub-clan, who reside in central and southern Somalia. Particularly the regions of Galmudug, Banaadir, and Hirshabelle. In Kenya, some members of the Karanle clan are found in Mandera County in the North Eastern Province.
Predošćica
Predošćica (Italian: Predoschizza) is a village located on the Croatian island of Cres, in Primorje-Gorski Kotar. Administratively, it is part of the town of Cres. As of 2021, it had a population of 1. A church devoted to Saint Blaise is situated in the village.

Saint Blaise
Blaise of Sebaste (Greek: Ἅγιος Βλάσιος, Hágios Blásios; Armenian: Սուրբ Վլաս; Latin: Blasius martyred 316 AD) was a physician and bishop of Sebastea in historical Lesser Armenia (modern Sivas, Turkey) who is venerated as a Christian saint and martyr. He is counted as one of the Fourteen Holy Helpers.

Blaise is a saint in the Catholic, Western Rite Orthodoxy, Eastern Orthodox and Oriental Orthodox Churches and is the patron saint of wool combers and of sufferers from ENT illnesses. In the Latin Church, his feast falls on 3 February. In the Eastern Churches, it is on 11 February. According to the Acta Sanctorum, he was martyred by being beaten, tortured with iron combs, and beheaded.
St Gwenfaen's Well
St Gwenfaen's Well (also known as Welsh: Ffynnon Gwenfaen, Welsh: Ffynnon Wenfaen and Welsh: Ffynnon Gwenfai) is an early medieval holy well in the south west of Holy Island, Anglesey, named after St Gwenfaen, whose cloister was nearby. The site includes substantial remains of a building and is both a scheduled monument and a Grade II listed building. Traditionally, a gift of two white quartz pebbles thrown into the pool can cure mental health problems.

Holy well
A holy well or sacred spring is a well, spring or small pool of water revered either in a Christian or pagan context, sometimes both. The water of holy wells is often thought to have healing qualities, through the numinous presence of its guardian spirit or Christian saint. They often have local legends associated with them; for example in Christian legends, the water is often said to have been made to flow by the action of a saint. Holy wells are often also places of ritual and pilgrimage, where people pray and leave votive offerings. In Celtic regions, strips of cloth are often tied to trees at holy wells, known as clootie wells.
Once Upon a Time (1933 film)
Once Upon a Time (French: Il était une fois) is a 1933 French drama film directed by Léonce Perret and starring Gaby Morlay, André Luguet and Andrée Ducret.

It was shot at the Joinville Studios in Paris. The film's sets were designed by the art director Guy de Gastyne.

According to Perret's biographer, critics found that the film, based on a play by Francis de Croisset, "bordered on the conflict between theatre technicians and film studio technicians".

Joinville Studios
The Joinville Studios were a film studio in Paris which operated between 1910 and 1987. They were one of the leading French studios, with major companies such as Pathé and Gaumont making films there.

A second studio was added to the original in 1923. This was located less than a kilometre away, and together the two served as a major filmmaking hub. After the Second World War the studio was merged into the Franstudio network in 1947 along with other major Paris studios including the Saint-Maurice Studios and Francoeur Studios.

In the early 1930s, the American company Paramount Pictures took over the studios and made French-language versions of their hit films. In total, films were made in fourteen different languages as Joinville became a hub of such multi-language versions. While many were remakes of English-language hits, some were original stories. This practice declined as dubbing became more commonplace.
Cakaudrove West (Open Constituency, Fiji)
Cakaudrove West Open is a former electoral division of Fiji, one of 25 open constituencies that were elected by universal suffrage (the remaining 46 seats, called communal constituencies, were allocated by ethnicity).  Established by the 1997 Constitution, it came into being in 1999 and was used for the parliamentary elections of 1999, 2001, and 2006. It was located in the southeastern part of the northern island of Vanua Levu.

The 2013 Constitution promulgated by the Military-backed interim government abolished all constituencies and established a form of proportional representation, with the entire country voting as a single electorate.

Vanua Levu
Vanua Levu (pronounced [βaˈnua ˈleβu], lit. 'Big Land', Fiji Hindi: वानुआ लेवु), formerly known as Sandalwood Island, is the second largest island of Fiji. Located 64 kilometres (40 miles) to the north of the larger Viti Levu, the island has an area of 5,587.1 square kilometres (2,157.2 sq mi) and a population of approximately 160,000 as of 2022.
Sambrook's Brewery
Sambrook's Brewery is a British brewery, based in Wandsworth, London. The location is the oldest continually brewing site in the UK.

Founded in 2008 by former City accountant Duncan Sambrook in nearby Battersea, the brewery was among the first wave of new London breweries in the early 21st century.

The brewery specialises in traditional cask ale and bottle and keg beers, many of them named after local landmarks in south-west London. Its flagship bitter Wandle is named after the River Wandle and has won several awards, including World's Best Bitter (pale beers up to 5% ABV) at the 2012 World Beer Awards.

Since relocating to Wandsworth in 2020–2021, Sambrook's has brewed on the former Young's Ram Brewery site, which local heritage bodies promote as the UK's oldest continuously brewing location, with origins in the sixteenth century.

World Beer Cup
The World Beer Cup is an international beer competition organized by the Brewers Association, a trade group representing America's small and independent craft brewers. It is the largest competition in the beer industry and has been described as "the Olympics of beer." According to americancraftbeer.com, "Winning a World Beer Cup is like winning a Grammy or an Oscar…it brings the world’s attention to even the smallest brewery’s doorstep…and like a hit song or film, it can make a career." The cup was founded by Association of Brewers president Charlie Papazian in 1996 and was awarded every two years until 2022, and has been held every year since then. The competition is held in conjunction with the Craft Brewers Conference & BrewExpo America.
Strange Eggs
Strange Eggs is a one-shot anthology of stories created by Steve Ahlquist and Chris Reilly, published by SLG Publishing (formerly Slave Labor Graphics).

The Strange Eggs concept has been extended from the original premise to The Weirdly World of Strange Eggs, a graphic novel based on the premise and aimed at younger children, and Strange Eggs Jumps the Shark. Contributing artists include: Roger Langridge, Tommy Kovac, and J. Chris Campbell.

Slave Labor Graphics
Slave Labor Graphics (SLG) is an American independent comic book publisher, well known for publishing darkly humorous, offbeat adult comics. Creators associated with SLG over the years include Evan Dorkin, Roman Dirge, Sarah Dyer, Woodrow Phoenix, Jhonen Vasquez, and Andi Watson.
Lionel Protip Sen
Lieutenant-General Lionel Protip "Bogey" Sen, DSO (20 October 1910 – 17 September 1981) was a decorated Indian Army general. He served as the Chief of the General Staff during 1959–1961 and commanded the Eastern Command during 1961–1963. He was the general responsible for countering the Chinese invasion of NEFA during the Sino-Indian War of 1962. Sen is also the author of Slender was the Thread, a military history of the Indo-Pakistani War of 1947–1948.

North-East Frontier Agency
The North–East Frontier Agency (NEFA), originally known as the North-East Frontier Tracts (NEFT), was one of the political divisions in British India, and later the Republic of India until 20 January 1972, when it became the Union Territory of Arunachal Pradesh and some parts of Assam. Its administrative headquarters was Shillong (until 1974, when it was transferred to Itanagar). It received state status on 20 February 1987.
Arboretum Robert Ruffier-Lanche
The Arboretum Robert Ruffier-Lanche (3 hectare) is an arboretum located on the campus of the Université Grenoble Alpes at 2233 rue de la Piscine, Saint-Martin-d'Hères, Isère, Rhône-Alpes, France. It is open daily without charge.

The arboretum was created in 1966 beside the Isère by Robert Ruffier-Lanche, head gardener of the Jardin botanique alpin du Lautaret. After some years of neglect, its restoration began in 1999. Today the arboretum contains over 200 species of trees and shrubs from temperate environments around the world, including particularly fine specimens of Davidia involucrata, Paulownia tomentosa var tsinlingensis, and Quercus rugosa.

It also contains a scaled model representation of the Solar System.

Rhône-Alpes
Rhône-Alpes (French pronunciation: [ʁon alp] ⓘ) was an administrative region of France. Since 1 January 2016, it is part of the new region Auvergne-Rhône-Alpes. It is located on the eastern border of the country, towards the south. The region was named after the river Rhône and the Alps mountain range. Its capital, Lyon, is the second-largest metropolitan area in France after Paris. Rhône-Alpes has the sixth-largest economy of any European region.
Lady Meriam
Lady Meriam Chong Abdullah, also known as Chong Ah Mei or Mariam Abdullah (died 1934), was the first wife of Tunku Abdul Rahman, who later became the founding father and the first Prime Minister of Malaysia.

Prime Minister of Malaysia
The prime minister of Malaysia (Malay: Perdana Menteri Malaysia; Jawi: ڤردان منتري مليسيا‎) is the head of government of Malaysia. The prime minister directs the executive branch of the federal government. The Yang di-Pertuan Agong appoints the prime minister who is a member of Parliament (MP) who, in his opinion, is most likely to command the confidence of a majority of MPs. The prime minister is usually the leader of the party winning the most seats in a general election.

After the formation of Malaysia on 16 September 1963, Tunku Abdul Rahman, whom was the chief minister of the Federation of Malaya at the time, became the first prime minister of Malaysia.

The current prime minister is Anwar Ibrahim, who was elected in the 2022 Malaysian general election.
Marcel Theroux
Marcel Raymond Theroux (born 13 June 1968) is an English-American novelist and broadcaster. He has written novels such as The Confessions of Mycroft Holmes: A Paper Chase (2001), A Blow to the Heart (2006), Far North (2009), and Strange Bodies (2013). He won the Somerset Maugham Award for The Confessions of Mycroft Holmes and the John W. Campbell Memorial Award for Strange Bodies. He has also hosted documentaries on various topics and worked for TV news stations in New York City and Boston.

Unreported World
Unreported World is a British foreign affairs program made by ITN Productions and broadcast by Channel 4 in the United Kingdom, first broadcast on 8 September 2000. Over the course of the program, reporters have travelled to dangerous locations all over the world in an attempt to uncover stories usually ignored by global media outlets. It is a critically acclaimed series on the lives of people in some of the fastest-changing areas of the world.
2026–27 Asian Le Mans Series
The 2026–27 Asian Le Mans Series will be the fifteenth season of the Automobile Club de l'Ouest's Asian Le Mans Series. It is the fourth 24 Hours of Le Mans-based series created by the ACO, following the American Le Mans Series (since merged with the Rolex Sports Car Series to form the IMSA SportsCar Championship), the European Le Mans Series and the FIA World Endurance Championship.

On 13 June 2025, during the 2025 24 Hours of Le Mans weekend. It was announced that this season will mark the debut of the Hypercar (LMDh and LMH) class in this series, which will be for Pro-Am entries only.

Pro–am
Pro–am (or pro/am, pro am, ProAm; a contraction of professional–amateur) refers to a sporting event where both professional career athletes and amateurs compete. It could also refer to a collaboration between professionals and amateurs in a scientific discipline such as astronomy.
Rye Valley, Oregon
Rye Valley is an unincorporated community in Baker County, in the U.S. state of Oregon. It lies along Dixie Creek, a tributary of the Burnt River, about 30 miles (48 km) southeast of Baker City. It is slightly west of Interstate 84 near Weatherby and Dixie.

The community is named for a native grass used as forage for pack animals important to the region's immigrants and miners in the 1860s. A Rye Valley post office opened on September 27, 1869, and operated intermittently between then and September 14, 1935. Nayson S. Whitcomb was the first postmaster.

On July 24, 2014, a wildfire started by lightning happened in Rye Valley. The lightning first struck on Bureau of Land Management lands; however, winds quickly drove it onto forestlands protected by the Oregon Department of Forestry. The fire took three days to fully contain.

Baker City, Oregon
Baker City is a city in and the county seat of Baker County, Oregon, United States. It was named after Edward Dickinson Baker, the only U.S. Senator ever killed in military combat. The population was 10,099 at the time of the 2020 census.
Heber Second Ward Meetinghouse
Built in 1915, the Heber Second Ward Meetinghouse, originally built as a place of worship for the Church of Jesus Christ of Latter-day Saints is of historical significance to Heber City, Utah. It was added to the National Register of Historic Places on December 12, 1978. Bishop Joseph A Rasband served as the Heber Second Ward's first bishop in the meetinghouse, and his first counselor James Heber Moulton was the superintendent that oversaw the building of the meetinghouse.  Joseph Nelson was the architect. Construction of the building was begun 16 Mar 1914; it was dedicated by Francis Lyman on December 26, 1915 and served the Second Ward into the 1960s when it was sold. The building is now the St. Lawrence Catholic Church.

Francis M. Lyman
Francis Marion Lyman (January 12, 1840 – November 18, 1916) was a member of the Quorum of the Twelve Apostles of the Church of Jesus Christ of Latter-day Saints (LDS Church). He was the President of the Quorum of the Twelve from 1903 until his death.

Lyman's father and son were also apostles in the church: his father was Amasa M. Lyman and his son was Richard R. Lyman. Both his father and son were excommunicated from the church while serving as apostles (although they were later re-baptized).
Pręgowo, Warmian-Masurian Voivodeship
Pręgowo [prɛnˈɡɔvɔ] is a village in the administrative district of Gmina Kętrzyn, within Kętrzyn County, Warmian-Masurian Voivodeship, in northern Poland. It lies approximately 8 km (5 mi) south of Kętrzyn and 62 km (39 mi) north-east of the regional capital Olsztyn.

Kętrzyn
Kętrzyn ([ˈkɛntʂɨn] ⓘ, until 1946 Rastembork; German: Rastenburg [ˈʁastn̩bʊʁk] ⓘ) is a town in northeastern Poland with 27,478 inhabitants (2019). It is the capital of Kętrzyn County in the Warmian–Masurian Voivodeship.

The town is known for the surrounding Masurian Lakeland and numerous monuments of historical value such as the Wolf's Lair in nearby Gierłoż, which was Adolf Hitler's primary headquarters over the course of Nazi Germany's military campaign on the Eastern Front during World War II. The town is also known for its 14th century Teutonic Kętrzyn Castle.
Emil Costello
Emil Antonio Costello (January 2, 1908 – February 9, 1994) was an American furniture worker and labor union activist from Kenosha, Wisconsin who served one term as a member of the Wisconsin State Assembly from Kenosha County. While he was elected as a Progressive, he was frequently accused of being a communist or fellow traveler who urged others to join the party.

Administrative divisions of Wisconsin
The administrative divisions of Wisconsin include counties, cities, villages and towns. In Wisconsin, all of these are units of general-purpose local government. There are also a number of special-purpose districts formed to handle regional concerns, such as school districts.

Whether a community is a city, village or town is not strictly dependent on the community's population or area, but on the form of government selected by the residents and approved by the Wisconsin State Legislature. Cities and villages can overlap county boundaries; for example, the city of Whitewater is located in Walworth and Jefferson counties.
Crête
Crête is a surname of French origin. Some persons with the surname include:

Joseph-Alphida Crête (1890–1964), Canadian politician

Martin Crête (born 1985), Canadian curler

Paul Crête (born 1953), Canadian politician

Stéphane Crête (born 1967), Canadian actor and comedian

Stéphane Crête
Stéphane Crête (September 19, 1967) is a Canadian actor and comedian from Quebec. He is known for his roles as Brad Spitfire in the Le Canal Famille television show Dans une galaxie près de chez-vous and Jacques Préfontaine on the Télévision de Radio-Canada miniseries Les Étoiles filantes.

In 2002, he won a Gémeaux Award for his work in Dans une galaxie près de chez-vous.