hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Tavapadon
Tavapadon (developmental code names CVL-751, PF-06649751) is a dopamine receptor agonist which is under development for the treatment of Parkinson's disease. It is under development by Cerevel Therapeutics, which acquired tavapadon from Pfizer in 2018. It is taken by mouth.

Tavapadon acts as a highly selective partial agonist of the dopamine D1 receptor (Ki = 9 nM; IATooltip Intrinsic activity = 65%) and the dopamine D5 receptor (Ki = 13 nM; IA = 81%). It has no significant affinity or functional activity at the D2-like receptors (D2, D3, D4) (Ki ≥ 4,870 to 6,720 nM). Tavapadon also shows biased agonism for Gs-coupled signaling at the D1-like receptors.

As of December 2024, tavapadon has completed phase 3 clinical trials for Parkinson's disease.

Dopamine receptor D2
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon H. Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now known as the dopamine D2 receptor. The dopamine D2 receptor is the main receptor for most antipsychotic drugs.  The structure of DRD2 in complex with the atypical antipsychotic risperidone has been determined.
The Costello School
The Costello School is an 11–16 mixed secondary school with academy status in Basingstoke, Hampshire, England.

It originally opened as Basingstoke High School for girls. It became Harriet Costello Secondary School in 1972 when it became a co-ed, but was renamed Costello Technology College after gaining specialist Technology College status. The school was converted to academy status on 1 July 2012 and was renamed The Costello School. Before becoming an academy it was a community school under the direct control of Hampshire County Council. The school continues to coordinate with Hampshire County Council for admissions. The school, as of 1 September 2018, is now part of the multi-academy trust (MAT) Bohunt Education Trust.

Technology College (United Kingdom specialist schools programme)
In the United Kingdom, a Technology College was part of the 2011-defunct specialist schools programme (SSP) in the United Kingdom. It was a specialist school that specialises in design and technology, mathematics and science. Beginning in 1994, they were the first specialist schools that were not CTC colleges. In 2008, there were 598 Technology Colleges in England, of which 12 also specialised in another subject.
3D Life
3D Life is a three-dimensional extension and exploration in the variants of Conway's Game of Life. It was first discovered by Carter Bays. A number of different semitotalistic rules for the 3D rectangular Moore neighborhood were investigated. It was popularized by A. K. Dewdney in his "Computer Recreations" column in Scientific American magazine.

Complex Systems (journal)
Complex Systems is a quarterly peer-reviewed open access scientific journal covering subjects ranging across a number of scientific and engineering fields, including computational biology, computer science, mathematics, and physics. It was established in 1987 with Stephen Wolfram as founding editor-in-chief. The journal is published by Complex Systems Publications.
2018 Evian Championship
The 2018 Evian Championship was played 13–16 September at the Evian Resort Golf Club in Évian-les-Bains, France. It was the 25th Evian Championship (the first 20 played as the Evian Masters), and the sixth as a major championship on the LPGA Tour. The event was televised by Golf Channel and NBC Sports in the United States and Sky Sports in the United Kingdom.

At the age of 40, Angela Stanford won her first major championship on her 76th appearance in a major. Four players tied for second place, a stroke behind, including Amy Olson who came to the last hole needing a par to win but made a double bogey.

Park Sung-hyun (golfer)
Park Sung-hyun (born 21 September 1993), also known as Sung Hyun Park, is a South Korean professional golfer playing on the U.S.-based LPGA Tour. She has won two LPGA majors championships, the 2017 U.S. Women's Open and the 2018 Women's PGA Championship. She was the number one ranked golfer in the Women's World Golf Rankings for a single week in 2017 and has returned to the number one spot in 2018 and 2019.
Stefano Bargauan
Stefano Bargauan (c. 1954 – June 2013) was an Italian figure skater. Competing in men's singles, he was the 1971 Prague Skate champion, 1970 Kennedy Memorial Winter Games bronze medalist, and Italian national champion. He also competed in ice dancing with Letizia Ghirardelli.

His siblings, Michele and Willy, also competed in figure skating. The family worked in television broadcasting.

Kennedy Memorial Winter Games
The Kennedy Memorial Winter Games were an international multi-sport competition event held in Lake Placid, New York, from January 9 to March 15, 1970.  The Games were held as a tribute to John F. Kennedy and his brother Robert F. Kennedy.  President Kennedy had been an advocate of physical fitness and in 1963 urged the development of programs to allow American youth to participate in international sports competitions. The program included competition in figure skating, bobsled, luge, ski jumping, cross-country skiing, and ice hockey.
Gemaga
Gemaga was a Japanese video game magazine founded in 1984 as Beep and published by SB Creative. During its history, it was known variously as Beep, Beep! MegaDrive, Sega Saturn Magazine, Dreamcast Magazine, Dorimaga, and finally Gemaga. When it ended publication in May 2012, it was the longest-running Japanese game magazine.

SB Creative
SB Creative Corp. (SBクリエイティブ株式会社, Esubī Kurieitibu Kabushiki gaisha) is a Japanese publishing company and a subsidiary of the SoftBank telecommunications company. It was founded in 1999 and is headquartered in Tokyo, Japan.
Zé Renato
Zé Renato (born José Renato Botelho Moschkovich in Vitória, Espírito Santo, April 1, 1956) is a Brazilian singer, songwriter, and guitarist.

He has released many albums and his songs have been recorded by Milton Nascimento, Jon Anderson, Leila Pinheiro, Lulu Santos, Nana Caymmi, MPB-4, and Boca Livre. He represented Brazil in the OTI Festival 1994 with the song "Mulher".

OTI Festival 1994
The OTI Festival 1994 (Spanish: Vigésimo Tercer Gran Premio de la Canción Iberoamericana, Portuguese: Vigésimo Terceiro Grande Prêmio da Canção Ibero-Americana) was the 23rd edition of the OTI Festival. It consisted of a semi-final on 14 October and a final on 15 October 1994, held at Teatro Principal in Valencia, Spain, and presented by Ana Obregón and Francisco. It was organised by the Organización de Televisión Iberoamericana (OTI) and host broadcaster Televisión Española (TVE), who staged the event after winning the 1993 festival for Spain with the song "Enamorarse" by Ana Reverte.

Broadcasters from twenty-four countries participated in the festival. The winner was the song "Canción despareja" performed by Claudia Carenzio representing Argentina; with "Cuestión de suerte" by Ana María representing Spain placing second; and "Enfurecida" by Luis Silva representing Venezuela placing third.
Liga IV Bihor
Liga IV Bihor is the county football division of Liga IV for clubs based in Bihor County, Romania. The competition is ranked as the fourth tier of the Romanian football league system and is organized by AJF Bihor – Asociația Județeană de Fotbal (lit. 'County Football Association').

It is contested by a variable number of teams, depending on the number of teams relegated from Liga III, the number of teams promoted from Liga V Bihor, and the teams that withdraw or enter the competition. The winner may or may not be promoted to Liga III, depending on the result of a promotion play-off contested against the winner of a neighboring county series.

Bihor County
Bihor County (Romanian pronunciation: [biˈhor] ⓘ, Hungarian: Bihar megye) is a county (județ) in western Romania. With a total area of 7,544 km2 (2,913 sq mi), Bihor is Romania's 6th largest county geographically and the main county in the historical region of Crișana. Its capital city is Oradea (Nagyvárad).
Prisma (chain store)
Prisma is a Finnish chain of hypermarkets belonging to S Group. In Finland there are currently 74 stores in 51 different cities. The first Prisma store opened in Jyväskylä in 1972. In addition to food and groceries, Prisma's selection includes a wide collection of clothing, sporting goods, books, toys, entertainment and home accessories.

Prisma's main competitor in Finland is Kesko's K-Citymarket chain. Prisma also has 14 hypermarkets in and around 5 cities in Estonia. The chain has also had stores in Latvia and Lithuania, but they were closed in 2017. On March 4, 2022, Prisma's owner, the S-Group, announced the closure of all Russian operations.

Hypermarket
A hypermarket or superstore is a big-box store combining a supermarket and a department store. The result is an expansive retail facility carrying a wide range of products under one roof, including full grocery lines and general merchandise. In theory, hypermarkets allow customers to satisfy all their routine shopping needs in one trip. The term hypermarket (French: hypermarché) was coined in 1968 by the French trade expert Jacques Pictet.

Hypermarkets, like other big-box stores, typically have business models focusing on high-volume, low-margin sales. Typically covering an area of 5,000 to 15,000 square metres (54,000 to 161,000 sq ft), they generally have more than 200,000 different brands of merchandise available at any one time. Because of their large footprints, many hypermarkets choose suburban or out-of-town locations that are easily accessible by automobile.
Gauss map
In differential geometry, the Gauss map  of a surface is a function that maps each point in the surface to its normal direction, a unit vector that is orthogonal to the surface at that point. Namely, given a surface X in Euclidean space R3, the Gauss map is a map N: X → S2 (where S2 is the unit sphere) such that  for each p in X, the function value N(p) is a unit vector orthogonal to X at p. The Gauss map is named after Carl F. Gauss.

The Gauss map can be defined (globally) if and only if the surface is orientable, in which case its degree is half the Euler characteristic. The Gauss map can always be defined locally (i.e. on a small piece of the surface). The Jacobian determinant of the Gauss map is equal to Gaussian curvature, and the differential of the Gauss map is called the shape operator.

Gauss first wrote a draft on the topic in 1825 and published in 1827.

There is also a Gauss map for a link, which computes linking number.

Linking number
In mathematics, the linking number is a numerical invariant that describes the linking of two closed curves in three-dimensional space.  Intuitively, the linking number represents the number of times that each curve winds around the other.  In Euclidean space, the linking number is always an integer, but may be positive or negative depending on the orientation of the two curves (this is not true for curves in most 3-manifolds, where linking numbers can also be fractions or just not exist at all).

The linking number was introduced by Gauss in the form of the linking integral.  It is an important object of study in knot theory, algebraic topology, and differential geometry, and has numerous applications in mathematics and science, including quantum mechanics, electromagnetism, and the study of DNA supercoiling.
Kabani (TV series)
Kabani is an Indian Malayalam television series directed by Sudheesh Sankar. The show premiered from 11 March 2019 which aired on Zee Keralam. It stars Gopika Anil, Prem Jacob and Keerthana Anil in lead roles along with Mallika Sukumaran and Krishna. The series is a remake of the Telugu language television show Mutyala Muggu.

Sudheesh Sankar
Sudheesh Sankar is an Indian film director who has directed Malayalam television serials and a few Tamil and Malayalam films.

His first directorial was the film Aarumaname. Sankar is known for the Dileep film Villali Veeran and the popular Malayalam TV-series  like Omanathinkal Pakshi, Ente Manasaputhri and Parasparam.
Kemsley
Kemsley, once a separate village, is now a suburb of Sittingbourne in Kent, England.

According to Asserius Menevensis in his contemporary survey, the Danes built a fortress or castle here in 893 at a place called 'Kemsley downe'. This later became 'Castle Rough'.

At the end of the 19th century, the site of the village was simply a row of cottages beside a brick works, located close to the remains of the medieval fortified manor house Castle Rough.

In 1924, with expansion impossible at the old Sittingbourne Paper Mills, owner Edward Lloyd built the new Kemsley Paper Mill, which served by a creek allowed the direct importation of raw materials to the site. At the same time he built a garden village to house his employees, the core of which comprises the modern day Kemsley village. The narrow gauge industrial railway which served the factory is now the preserved Sittingbourne and Kemsley Light Railway, a tourist attraction. Kemsley railway station is on the Sheerness Line.

Garden city movement
The garden city movement was a 20th-century urban planning movement promoting satellite communities surrounding the central city and separated with greenbelts. These Garden Cities would contain proportionate areas of residences, industry, and agriculture. Ebenezer Howard first posited the idea in 1898 as a way to capture the primary benefits of the countryside and the city while avoiding the disadvantages presented by both. In the early 20th century, Letchworth and Welwyn Garden City were built near London according to Howard's concept and many other garden cities inspired by his model have since been built all over the world.
HegartyMaths
HegartyMaths was an educational subscription tool used by schools in the United Kingdom. It was sometimes used as a replacement for general mathematics homework tasks. Its creator, Colin Hegarty, was the UK Teacher of the Year in 2015 and shortlisted for the Varkey Foundation's Global Teacher Prize in 2016.

Varkey Foundation
The Varkey Foundation, initially the Varkey GEMS Foundation, is the nonprofit arm of GEMS Education, an education management company. It was formed in 2010 by Indian businessman Sunny Varkey, GEMS chairman.

The Varkey Foundation has partnered with a variety of major global organizations including UNESCO, UNICEF, and the Clinton Global Initiative. It gives out the Global Teacher Prize, a US$1 million award.
Uncus
The uncus is an anterior extremity of the parahippocampal gyrus.  It is separated from the apex of the temporal lobe by a sulcus called the rhinal sulcus.
Although superficially continuous with the hippocampal gyrus, the uncus forms morphologically a part of the rhinencephalon.

An important landmark that crosses the inferior surface of the uncus is the band of Giacomini or tail of the dentate gyrus.

The term comes from the Latin word uncus, meaning hook, and it was coined by Félix Vicq-d'Azyr (1748–1794).

Temporal lobe
The temporal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The temporal lobe is located beneath the lateral fissure on both cerebral hemispheres of the mammalian brain.

The temporal lobe is involved in processing sensory input into derived meanings for the appropriate retention of visual memory, language comprehension, and emotion association.: 21 
Temporal refers to the head's temples.
Němeček
Němeček (feminine Němečková) is a Czech surname, meaning "a small German". It is a diminutive of Němec, meaning "a German". It can be Anglicized as Nemechek or simply Nemecek. Notable people include:

Bohumil Němeček, Czech boxer

Franz Xaver Niemetschek, Czech music scholar

Jan Němeček, Czech ice hockey player

Lenka Němečková, Czech tennis player

Libor Němeček, Czech tennis player

Svatopluk Němeček, Czech politician

Václav Němeček, Czech footballer

Franz Xaver Niemetschek
Franz Xaver Niemetschek (Czech: František Xaver Němeček; 24 July 1766 – 19 March 1849) was a Czech philosopher, teacher and music critic. He wrote the first full-length biography of Wolfgang Amadeus Mozart which has remained an important source of information about the composer.
Equal Love
Equal Love is an Australian-wide campaign initiated by the Victorian Gay and Lesbian Rights Lobby in an attempt to win gay and lesbian couples marriage rights in the country. The campaign involves a range of community, union, student and activist organisations whose aim is to influence public and government attitudes towards LGBTQ couples through education and direct action.

Direct action
Direct action is a form of activism in which participants use economic power or political power to achieve their goals. The aim of direct action is to either obstruct a certain practice such as a government's laws or actions or to draw attention to and create a dialogue in order to solve perceived problems.

Direct action may include activities, that can be either violent or nonviolent, targeting people, groups, institutions, actions, or property that its participants deem objectionable. Violent direct action may include political violence, assault, arson, sabotage, and property destruction. Nonviolent direct action may include peaceful demonstrations, civil disobedience, sit-ins, strikes, and counter-economics.
Jean-Charles François
Jean-Charles François (4 May 1717 – 22 March 1769) was a French engraver.

François was born in Nancy then in the Duchy of Lorraine. He was among the pioneers of the so-called "manière de crayon" ("crayon manner") of printmaking, which simulated the appearance of crayon and chalk drawings. He was pensioned by King Louis XV, who employed him extensively. His most noted works represent Louis XV, Marie Leszczyńska, Pierre Bayle, Erasmus, John Locke, and Nicolas Malebranche.

He died in 1769 in Paris, aged 51.

Nicolas Malebranche
Nicolas Malebranche CO (/mælˈbrɒnʃ/ mal-BRONSH; French: [nikɔla malbʁɑ̃ʃ]; 6 August 1638 – 13 October 1715) was a French Oratorian Catholic priest and rationalist philosopher. In his works, he sought to synthesise the thought of St. Augustine and Descartes, in order to demonstrate the active role of God in every aspect of the world. Malebranche is best known for his doctrines of vision in God, occasionalism and ontologism.
Alistair Gunn
Alistair Robert Gunn (2 November 1924 – 3 April 2010) was a professional footballer, who played for Dundee, Huddersfield Town, Bournemouth & Boscombe Athletic & Arbroath. He was born in Broughty Ferry, Dundee, Scotland.

Arbroath F.C.
Arbroath Football Club is a semi-professional Scottish football club based in the town of Arbroath, Angus. They currently play in the Scottish Championship. The club was founded in 1878 and plays home matches at Gayfield Park. They play in maroon strips and are nicknamed "The Red Lichties" due to the red light that used to guide fishing boats back from the North Sea to the Burgh's harbour. The Red Lichties share a long-standing and fierce rivalry with local neighbours Montrose, as well as with fellow local sides Forfar Athletic and Brechin City.
Benezet House
Benezet House, also known as Benezette House, is an historic dormitory located on the campus of Penn Center. It was erected in 1905 and named after Frenchman, Anthony Benezet, who stood for freedom in the mid- and late-1870's. The female teachers and female boarding students of Penn School were housed here. The mandatory nightly chapel service held in the ground floor lobby was, however, open to both male and female students. This location was the focal point of home economics training for female students, each of whom were required to reside in Benezet before they graduated. Today, Benezet House is used to house overnight guests to Penn Center.

Anthony Benezet
Anthony Benezet (January 31, 1713 – May 3, 1784) was a French-born American abolitionist and teacher who was active in Philadelphia, Pennsylvania. A prominent member of the abolitionist movement in North America, Benezet founded one of the world's first anti-slavery societies, the Society for the Relief of Free Negroes Unlawfully Held in Bondage. He also founded the first public school for girls in North America and the Negro School at Philadelphia, which operated into the nineteenth century. Benezet advocated for kind treatment of animals, racial equality and universal love.
Area code 636
Area code 636 is a telephone area code in North American Numbering Plan (NANP) for the east-central part of the U.S. state of Missouri, comprising mainly the western suburbs of St. Louis. It includes parts of Chesterfield and Fenton in St. Louis County, and all of St. Charles, Jefferson, and Warren counties, all of Franklin County with the exception of Sullivan, as well as the towns of High Hill and Jonesburg in Montgomery County and the southern portion of Lincoln County. It was created in 1999 in an area code split from area code 314, which was one of the original North American area codes of 1947.

Warren County, Missouri
Warren County is a county located in the eastern portion of the U.S. state of Missouri. As of the 2020 census, the population was 35,532. The county is located on the north side of the Missouri River. Its county seat is Warrenton. The county was established on January 5, 1833, and was named for General Joseph Warren, who died in the Battle of Bunker Hill during the American Revolutionary War.

Warren County is part of the St. Louis, MO-IL Metropolitan Statistical Area. The county is traversed by Route 94, called the "Missouri Weinstrasse" because of the many vineyards from Marthasville east into St. Charles County. Warren County is also part of the Missouri Rhineland, with award-winning wineries located on both sides of the Missouri River.
Nata de coco
Nata de coco, also marketed as coconut gel, is a chewy, translucent, jelly-like food produced by the fermentation of coconut water, which gels through the production of microbial cellulose by Komagataeibacter xylinus.

Originating in Ramon, Isabela, nata de coco was invented in 1949 by Teódula Kalaw África as an alternative to the traditional Filipino nata de piña made from pineapples. It is most commonly sweetened as a candy or dessert, and can accompany a variety of foods, including pickles, drinks, ice cream, puddings, and fruit cocktails.  Nowadays, nata de coco can be made using ground konjac plant fibers. The konjac in the composition helps make nata de coco low in calories.  Nata de coco with added konjac is often used to make low-calorie bubble tea.

Pineapple
The pineapple (Ananas comosus) is a tropical plant with an edible fruit; it is the most economically significant plant in the family Bromeliaceae.

The pineapple is indigenous to South America, where it has been cultivated for many centuries. The introduction of the pineapple plant to Europe in the 17th century made it a significant cultural icon of luxury. Since the 1820s, pineapple has been commercially grown in greenhouses and many tropical plantations. The fruit, particularly its juice, has diverse uses in cuisines and desserts.

Pineapples grow as a small shrub; the individual flowers of the unpollinated plant fuse to form a multiple fruit. The plant normally propagates from the offset produced at the top of the fruit or from a side shoot, and typically matures within a year.