hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
BI-3406
BI-3406 is a drug that acts as an inhibitor of the guanine nucleotide exchange factor protein SOS1, and prevents it from binding to its target protein KRAS. It has potential applications in the treatment of cancer, and has been widely used in cancer research either in combination with other drugs or as a lead compound for the development of related compounds.

Lead compound
A lead compound (/ˈliːd/, i.e., a "leading" compound; not to be confused with various compounds of the element lead) in drug discovery is a chemical compound that has pharma­co­logical or biological activity likely to be therapeutically useful, but may never­the­less have suboptimal structure that requires modification to fit better to the target; lead drugs offer the prospect of being followed by "back-up" compounds. The chemical structure serves as a starting point for chemical modifications in order to improve potency, selectivity, or pharma­co­kinetic parameters. Furthermore, newly-invented pharma­co­logically active moieties may have poor druglikeness and may require chemical modification to become "drug-like" enough to be tested biologically or clinically.

Lead compounds are sometimes called developmental candidates. This is because the discovery and selection of lead compounds occurs prior to preclinical and clinical development of the candidate.
Michał Zdzisław Zamoyski
Michał Zdzisław Zamoyski (1679–1735) was a Polish nobleman (szlachcic).

Michał became the 6th Ordynat of Zamość estate. He was Great Łowczy of the Crown since 1714, voivode of Smolensk Voivodeship since 1732 and starost of Gniew, Bratian, Lębork, Bolemów. He became Knight of the Order of the White Eagle, awarded on 3 August 1732.

Starosta
Starosta /ˈstɑːrɒstə/ or starost (Cyrillic: старост/а, Latin: capitaneus, German: Starost, Hauptmann) is a community elder in some Slavic lands.

The Slavic root of "starost" translates as "senior". Since the Middle Ages, it has designated an official in a leadership position in a range of civic and social contexts throughout Central and Eastern Europe. In reference to a municipality, a starosta was historically a senior royal administrative official, equivalent to a county sheriff or seneschal, and analogous to a gubernator. In Poland, a starosta administered a crown land district called starostwo.

In the early Middle Ages, a starosta could head a settled urban or rural community or other community, as in the case of a church starosta or an artel starosta. A starosta also functioned as a master of ceremonies.
Karsten Stenersen
Karsten Stenersen (born 24 September 1971) is a Norwegian former cyclist. He competed in two events at the 1992 Summer Olympics, placing eleventh in the time trial. He is the brother of Bjørn Stenersen.

Cycling at the 1992 Summer Olympics
The cycling competitions at the 1992 Olympic Games in Barcelona consisted of two different categories: road cycling and track cycling, with ten events being contested. The road team time trial event took place at the Circuit de Catalunya and the A-17 highway, the individual road races were held in Sant Sadurní d'Anoia, and track cycling took place at the Velòdrom d'Horta.
Don't Give It Up (Robbie Patton song)
"Don't Give it Up" is a 1981 song by English singer/songwriter Robbie Patton . It is Patton's first and only Top 40 hit on the Billboard Hot 100. "Don't Give it Up" reached #26 in the United States in 1981.

The song is co-produced by Fleetwood Mac producer Ken Caillat, Fleetwood Mac keyboardist Christine McVie, and Patton. Fleetwood Mac members Bob Weston, Christine McVie, Bob Welch, and Lindsey Buckingham are featured as performers. Also, Colin Allen, who co-wrote Fleetwood Mac's "Wish You Were Here" is featured on the track as well.

On November 19, 1981, Bob Welch invited Robbie Patton, Christine McVie, Joey Brasler, David Adelstein, Alvin Taylor, and Robin Sylvester to perform the track during his concert in The Roxy Theatre in California. The live performance was later released on Welch's "Live at The Roxy" album in 2004.

Ken Caillat
Kenneth Douglas Caillat (/kæˈleɪ/ kal-AY) (born August 12, 1946) is an American record producer. He is best known for producing the Fleetwood Mac albums Rumours, Tusk and Mirage. He is the father of singer Colbie Caillat.
Mahama Jeduah
Mahama Jeduah (born 19 December 1944) is a Ghanaian politician and teacher. He served as a member of the first parliament of the fourth republic of Ghana for Bole/ Bole Bamboi constituency in the Northern region of Ghana.

Northern Region (Ghana)
The Northern Region is one of the sixteen regions of Ghana. It is situated in the northern part of the country and ranks as the second largest of the sixteen regions. Before its division, it covered an area of 25,000 square kilometres, representing 10 percent of Ghana's area. In December 2018, the Savannah Region and North East Region were created from it.  The Northern Region is divided into 16 districts. The region's capital is Tamale,  Ghana's third-largest city.
Left is Change
Left is Change (Sinistra è Cambiamento, SèC) was a social-democratic faction within the Democratic Party (PD), a political party in Italy. Most of its members hailed from the Democrats of the Left (DS).

The faction was formed, mainly by splinters of Remake Italy and Reformist Area, in June 2015. At its foundation, the faction counted around 70 MPs, notably including Maurizio Martina (minister of Agriculture in Renzi Cabinet), Cesare Damiano, Anna Finocchiaro, Matteo Mauri, Enzo Amendola, Paola De Micheli and Luciano Pizzetti. Differently from other left-wing factions, notably Reformist Area, SèC wanted to cooperate with Matteo Renzi, PD leader and Prime Minister.

In the run-up of the 2017 leadership election, Martina and the majority of SèC chose to support Renzi, while a minority led by Damiano and Finocchiaro, endorsed Andrea Orlando of Remake Italy. The followers of Martina formed Future! European Democrats, while those of Damiano re-organised themselves as the Dem Labourites.

Paola De Micheli
Paola De Micheli (Italian pronunciation: [ˈpaːola de miˈkɛːli]; born 1 September 1973) is an Italian manager and politician of the Democratic Party (PD), who served as Minister of Infrastructure and Transport in the government of Prime Minister Giuseppe Conte from 2019 until 2021; she was the first woman to hold the office.
Scotty Barnhart
William "Scotty" Barnhart (born October 27, 1964) is an American jazz trumpeter. A three-time Grammy Award winner, he has played as a featured soloist with the Count Basie Orchestra since 1993. In September 2013, he was announced as the new director of the Basie Orchestra. He has multiple recordings with pianist Marcus Roberts, as well as recordings with Tony Bennett, Diana Krall, Ray Charles, and Tito Puente. His debut album, Say It Plain, released on Unity Music, features Clark Terry, Ellis Jr. and Wynton Marsalis, Marcus Roberts, Jamie Davis, and Etienne Charles; it achieved number 3 on the Jazz Charts. Also active as an educator and clinician, he is author of The World of Jazz Trumpet - A Comprehensive History and Practical Philosophy (published by Hal Leonard). He is a professor at the Florida State University College of Music.

He was born in Atlanta, Georgia and was a member of the historic Ebenezer Baptist Church where he was christened by Martin Luther King Jr.

Ebenezer Baptist Church
Ebenezer Baptist Church is a progressive Baptist megachurch located in Atlanta, Georgia, United States, affiliated with the Progressive National Baptist Convention and American Baptist Churches USA. It was the church where Dr. Martin Luther King Sr. was pastor from the 1930s and co-pastor together with his sons Dr. Martin Luther King Jr. from 1960 until his assassination in 1968 and A. D. King from 1968 until his death in 1969. It hosted the funerals of both Dr. King and, in its later expanded sanctuary, congressman John Lewis, and it is the church for which United States Senator Raphael Warnock has been pastor since 2005. Its historic church building and expanded sanctuary building are located in the historic area designated as the Martin Luther King Jr. National Historical Park.
Wenquan, Chongqing
Wenquan (simplified Chinese: 温泉; traditional Chinese: 溫泉; pinyin: Wēnquán; lit. 'hot springs') is a town of Kai County in the northeast of Chongqing Municipality, People's Republic of China, located more than 270 km (170 mi) northeast of central Chongqing. As of 2011, it has three residential communities (社区) and 11 villages under its administration.

Kaizhou, Chongqing
Kaizhou District (Chinese: 开州区), formerly known as Kai County, Kaixian or Kaihsien (Chinese: 开县) is a district under the jurisdiction of Chongqing Municipality, in southwestern China, bordering Sichuan province to the west. It has an area of 3,959 square km. As of the end of 2009, it had a population of 1.62 million. It is located 330 kilometers from the urban centre of Chongqing proper.
Football at the 2025 SEA Games – Men's tournament – Group C
Group C of the men's football tournament at the 2025 SEA Games was 
played from 5 to 12 December 2025. The group consisted of Indonesia, Myanmar, and the Philippines. Originally, Singapore were drawn in this group, but due to Cambodia's withdrawal, their draw was revised and Singapore were moved to Group A.

Philippines national under-23 football team
The Philippines national under-23 football team represents the Philippines in international football competitions in the Olympic Games, Asian Games, Southeast Asian Games and any other under-23 international football tournaments.  It is controlled by the Philippine Football Federation, the governing body of football in the country.

Their best finish in the ASEAN U-23 Championship is in 2025, when they reached the semifinals.

At the SEA Games, the team has achieved its best finish in the 2025 edition in Thailand by advancing to the semifinals. This at least matched the finishing of the senior team in the 1991 SEA Games.
Yosef Tzvi Dushinsky (third Dushinsky rebbe)
Yosef Tzvi Dushinsky (Hebrew: יוסף צבי דושינסקי) is the third Rebbe of the Dushinsky Hasidic dynasty of Jerusalem, Israel. He assumed the leadership of the Hasidut upon the death of his father, Rabbi Yisroel Moshe Dushinsky, second Dushinsky Rebbe, in 2003. The Dushinsky Hasidic movement was founded by his grandfather and namesake, Rabbi Yosef Tzvi Dushinsky, in Jerusalem in the 1930s. Both his father and grandfather also served as Gaavad (chief rabbi) of the Edah HaChareidis.

He has one brother, Rabbi Mordechai Yehuda Dushinsky, who is Rav of the Dushinsky community in Beit Shemesh.

The Rebbe heads Yeshivas Beis Yosef Tzvi, the movement's flagship yeshiva on Shmuel HaNavi Street in Jerusalem, as well as the movement's other educational institutions, which have close to 3,000 students in Jerusalem, Bnei Brak, Ashdod, and other locales.

He and his family reside in the Shmuel HaNavi neighborhood of Jerusalem.  He is the son-in-law of Rav Zalman Leib Meisels, the Seagate Rov.

Shmuel HaNavi (neighborhood)
Shmuel HaNavi (Hebrew: שיכון שמואל הנביא, Shikun Shmuel HaNavi, lit. "Samuel the Prophet neighborhood") is a neighborhood in north-central Jerusalem. It is bordered by the Sanhedria Cemetery to the north, Maalot Dafna to the east, Arzei HaBira to the south, and the Bukharan Quarter to the west. It is named after Shmuel HaNavi (Samuel the Prophet) Street, which runs along its western border and is the main road leading to the tomb of Samuel the prophet (Hebrew: Shmuel HaNavi) just outside Jerusalem's city limits.
Anyway the Wind Blows
Anyway the Wind Blows is the second and final studio album by American country music duo Brother Phelps. After its release, Doug re-joined country rock band The Kentucky Headhunters, of which he and Ricky Lee were both members previous to Brother Phelps' inception. This album produced singles in its title track and "Not So Different After All", although neither charted in the Top 40 on the Billboard country charts. The title track was originally recorded by J. J. Cale on his 1974 album Okie. The track "Ragtop" was previously recorded by The Kentucky Headhunters on their 1989 debut album Pickin' on Nashville, while "Cinderella" is a cover of a song originally released by the rock band Firefall. "Down into Muddy Water" would later be recorded by Shelly Fairchild on her 2004 debut album Ride.

Brother Phelps
Brother Phelps was an American country music duo from Edmonton, Kentucky. The duo consisted of brothers Ricky Lee Phelps and Doug Phelps, both vocalists and guitarists. Both brothers had left the Southern rock band the Kentucky Headhunters. In 1993, Brother Phelps charted with its debut single "Let Go", which reached a peak of No. 6 on the Billboard country music charts. In all, the duo charted six singles between 1993 and 1995 (although only one other single reached Top 40), in addition to recording two albums on Asylum Records. Brother Phelps disbanded in 1995, with Doug rejoining the Kentucky Headhunters as lead singer, and Ricky Lee assuming a solo career.
Bharatiya Janata Party – Bihar
Bharatiya Janata Party – Bihar (BJP Bihar) is a state unit of the Bharatiya Janata Party in Bihar. Sanjay Saraogi the current president of the BJP Bihar. Ramdeo Mahto was founding leader of BJP in Bihar.

Sanjay Saraogi
Sanjay Saraogi  (born in 1969) is a leader of Bharatiya Janata Party and a member of the Bihar Legislative Assembly. He currently serves as the president of the BJP Bihar since December 2025. He was elected to the Assembly for the first time in February 2005 and again in October 2005, then again in 2010, defeating the nearest RJD candidate by a margin of 26,000 votes from Darbhanga. He again defeated Mahagathbandhan candidate and former mayor Om Prakash Kheria by a margin of 7000 votes in the 2015 Bihar assembly election. In April 2018, he was appointed Chairman of Prakalan Samiti. In the 2020 Bihar Assembly Election, he again defeated RJD candidate Amarnath Gami by the margin of more than 10,000 votes.
Hakodate-Esashi Expressway
The Hakodate-Esashi Expressway (函館江差自動車道, Hakodate-Esashi Jidōshadō) is an incomplete two-lane national expressway in Oshima Subprefecture of Hokkaido, Japan. It is owned and operated by Ministry of Land, Infrastructure, Transport and Tourism and is signed E5A as an extension of the Hokkaido Expressway under the "2016 Proposal for Realization of Expressway Numbering."

Oshima Subprefecture
Oshima (渡島総合振興局, Oshima-sōgō-shinkō-kyoku) is a subprefecture of Hokkaido Prefecture, Japan. As of 2004, it had a population of 456,621 and an area of 3,715.38 km2.

Hakodate Airport is located in the City of Hakodate.
Matadana
Matadana (meaning: voting) is a 1965 novel written by the famous Kannada writer, philosopher, thinker S L Bhyrappa. An award winning Kannada movie Mathadana based on this novel, which was directed by T N Seetharam secured 'Best Regional Film' award at 47th National Film Awards. Matadana reveals the caste based politics and other dynamics that grip the democratic institution of ballot box in India.

47th National Film Awards
The 47th National Film Awards, presented by Directorate of Film Festivals, the organisation set up by Ministry of Information and Broadcasting, India to felicitate the best of Indian Cinema released in the year 1999. Ceremony took place on 18 September 2000 and awards were given by then President of India, K. R. Narayanan.
Boncompagni Ludovisi Decorative Art Museum
Boncompagni Ludovisi Decorative Arts Museum (Museo Boncompagni Ludovisi per le arti decorative, often abbreviated as the Museo Boncompagni), Rome, is the Decorative Arts Museum of the National Gallery of Modern Art of Rome. The Museum is located at Via Boncompagni, 18, near the elegant and historical Via Veneto.

Via Veneto
Via Vittorio Veneto (Italian pronunciation: [ˈviːa vitˈtɔːrjo ˈvɛːneto]), colloquially called Via Veneto, is one of the most famous, elegant, and expensive streets of Rome, Italy. The street is named after the Battle of Vittorio Veneto (1918), a decisive Italian victory of World War I. Federico Fellini's 1960 film La Dolce Vita was mostly centered on the Via Veneto area.
Qaṣr al-Shamsīyya
Qaṣr al-Shamsīyya (Arabic: قصرالشمسية, romanized: Qaṣr al-Shamsīyya) is a ruined palace in the al-Futah district of Riyadh, Saudi Arabia. It was built for Princess Nura bint ʿAbd al-Raḥman (1875–1950), the elder sister of King ʾAbd al-ʿAzīz Ibn Saud. The palace was north of the old town, not far from the Murabba Palace. Among the distinguished female visitors to the palace was Violet Dickson, the wife of H. R. P. Dickson. In his Riyadh map in The Arab of the Desert, Dickson referred to the palace as Qasr Nura, a name found often in other maps and documents. The building stood near the Riyadh Water Tower. By the late 1970s, the building was no longer occupied and had fallen into dereliction.

Riyadh Water Tower
Riyadh Water Tower (Arabic: برج مياه الرياض), locally known as Burj al-Khazzaan (Arabic: برج الخزان, lit. 'the reservoir tower') or simply al-Khazzaan (Arabic: الخزان, lit. 'the reservoir'), is a 61-meters tall conical-shaped cylindrical water tower and a prominent cultural landmark in the al-Futah neighborhood of Riyadh, Saudi Arabia. Designed by Swedish architect Sune Lindström and modeled after the Svampen water tower in Örebro, Sweden, it was the tallest structure in the country at the time of its inauguration in 1971 and is today located within the precincts of al-Watan Park in the King Abdulaziz Historical Center. The famous Khazan Street in the city is named after the water tower.
The Valkhof at Nijmegen
The Valkhof at Nijmegen is an oil painting by the Dutch Golden Age painter Aelbert Cuyp, likely painted between 1652 and 1654. It is now held in the Indianapolis Museum of Art.

The Valkhof at Nijmegen typifies the Dutch landscape. A small boat filled with fisherman wait to capture lobsters. Two fat cows sit at the bank of the river, with their herder and two guests. The herder's red jacket is the focal point, drawing the eye in and breaking up the muted tones of the rest of the painting. Across the river, the looming Medieval architecture is bathed in a warm golden light from the seemingly setting sun. Boats float peacefully down the water banks, not disturbing the water. A windmill pokes up from the cliff face. Small, chunky clouds hover peacefully over the bay. Overall, the feelings of peace and tranquility run through the painting, with the stillness of the cattle, people, and water all reflecting the peaceful nature of the painting.

Aelbert Cuyp
Aelbert Jacobszoon Cuyp or Cuijp (Dutch pronunciation: [ˈɑlbər ˈtɕaːkɔpsoːŋ ˈkœyp]; 20 October 1620 – 15 November 1691) was one of the leading Dutch Golden Age painters, producing mainly landscapes. The most famous of a family of painters, the pupil of his father, Jacob Gerritszoon Cuyp (1594–1651/52), he is especially known for his large views of Dutch riverside scenes in a golden early morning or late afternoon light. He was born and died in Dordrecht.
Govetts Leap Falls
The Govetts Leap Falls, or simply Govetts Leap, is a bridal veil waterfall on the Govetts Leap Brook where it falls 180 metres (591 ft) over Taylor Wall, located at Govetts Leap Lookout approximately 2.4 kilometres (1.5 mi) east of Blackheath in the Blue Mountains region of New South Wales, Australia. It is the 17th tallest waterfall in Australia.

Blackheath, New South Wales
Blackheath (postcode: 2785) is a town located near the highest point of the Blue Mountains, between Katoomba and Mount Victoria in New South Wales, Australia. The town's altitude is about 1,065 m (3,494 ft) AHD and it is located about 120 km (75 mi) west north-west of Sydney, 11 km (6.8 mi) north-west of Katoomba, and about 30 km (19 mi) south-east of Lithgow.

Blackheath has a vibrant artistic community and hosts two monthly markets – the Blackheath Growers Market and The Blackheath Community Market, as well as annual Christmas markets, antique markets and bimonthly craft markets. The town has many community activities, such as the Blackheath Philosophy Forum, which was founded in 2002 to arrange public discussion forums on philosophy and related topics.

As Blackheath has grown, more and more shops have appeared. Various shops from the late 1800s still stand in Blackheath.
American High-Speed Rail Act
The American High-Speed Rail Act is a legislative proposal introduced in the United States Congress aimed at accelerating the development and deployment of high-speed rail (HSR) and higher-speed rail projects across the country. The bill was introduced in March 2024 by Representative Seth Moulton (D‑MA) and Representative Suzan DelBene (D‑WA), reflecting a renewed federal commitment to modernizing American rail infrastructure and promoting sustainable transportation.

Higher-speed rail
Higher-speed rail (HrSR) is used to describe inter-city passenger rail services that have top speeds higher than conventional rail but not fast enough to be called high-speed rail services. The term is also used by planners to identify the incremental rail improvements to increase train speeds and reduce travel time as alternatives to larger efforts to create or expand the high-speed rail networks.

Though the definition of higher-speed rail varies from country to country, most countries refer to rail services operating at speeds up to 200 km/h (125 mph).

The concept is usually viewed as stemming from efforts to upgrade a legacy railway line to high speed railway standards (speeds in excess of 250 km/h or 155 mph), but usually falling short on the intended speeds. The faster speeds are achieved through various means including new rolling stock such as tilting trains, upgrades to tracks including shallower curves, electrification, in-cab signalling, and less frequent halts/stops.
Steynsburg
Steynsburg is a small town in the Walter Sisulu Local Municipality of the Joe Gqabi District Municipality, Eastern Cape province of South Africa. Steynsburg is located on the intersection of the R56 and R390.

The town lies 64 kilometres (40 mi) south-west of Burgersdorp and 48 kilometres (30 mi) north of Hofmeyr. It developed around the Reformed Church established in 1872 and has been administered by a village management board since 1874. Steynsburg is named after Douwe Gerbrandt Steyn, grandfather of President Paul Kruger.

Steynsburg has a well-established Provincial hospital.

Hofmeyr
Hofmeyr is a small Karoo town in the Eastern Cape Province of South Africa, 20 km west of the Bamboesberg mountain range. It lies 64 km north-east of Cradock at an altitude of 1,252 metres. According to the 2011 census, the population of Hofmeyr proper is about 326 persons and the neighbouring township of Luxolweni is about 3354. In former times it lay at the centre of a flourishing sheep-farming district and managed some salt pans 10 km to its west.

Founded in 1873, the town was initially named Maraisburg. To avoid confusion with the Gauteng area of Maraisburg it was renamed Hofmeyr in 1911  in honour of Jan Hendrik Hofmeyr (Onze Jan), a campaigner for the equal treatment of Afrikaans and English and a prominent figure in the Eerste Taalbeweging.