hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
WAY-204688
WAY-204688, also known as SIM-688, is a synthetic nonsteroidal estrogen and nuclear factor κB (NF-κB) inhibitor which was originated by ArQule and Wyeth and was under development by Wyeth for the treatment of rheumatoid arthritis, non-specific inflammation, and sepsis but was never marketed. It is a "pathway-selective" estrogen receptor (ER) ligand which inhibits NF-κB with an IC50Tooltip half-maximal inhibitory concentration of 122 nM and with maximal inhibition relative to estradiol of 94%. Inhibition of NF-κB by WAY-204688 appears to be dependent on agonism of the ERα, as it is reversed by the ERα antagonist fulvestrant, but is not dependent on the ERβ. In contrast to the case of NF-κB inhibition, WAY-204688 produces only slight elevation of creatine kinase in vitro, a measure of classical estradiol effects. It reached phase I clinical trials prior to the discontinuation of its development.

Intrinsic activity
Intrinsic activity (IA) and maximal efficacy (Emax) refer to the relative ability of a drug-receptor complex to produce a maximum functional response. This must be distinguished from the affinity, which is a measure of the ability of the drug to bind to its molecular target, and the EC50, which is a measure of the potency of the drug and which is proportional to both efficacy and affinity. This use of the word "efficacy" was introduced by Stephenson (1956) to describe the way in which agonists vary in the response they produce, even when they occupy the same number of receptors. High efficacy agonists can produce the maximal response of the receptor system while occupying a relatively low proportion of the receptors in that system. There is a distinction between efficacy and intrinsic activity.
20th Artillery Regiment "Piave"
The 20th Artillery Regiment "Piave" (Italian: 20° Reggimento Artiglieria "Piave") is an inactive field artillery regiment of the Italian Army, which was based in Maniago in Friuli-Venezia Giulia. Originally an artillery regiment of the Royal Italian Army, the regiment was formed in 1888 and served in World War I on the Italian front. In 1935 the regiment was assigned to the 10th Infantry Division "Piave", with which the regiment served in World War II. After the Armistice of Cassibile was announced on 8 September 1943, the division and its regiments were disbanded on 10 September by invading German forces.

The unit was reformed in 1975 as 20th Self-propelled Field Artillery Group "Piave" and assigned to the 132nd Armored Brigade "Manin". With the end of the Cold War the group was disbanded in 1991. The regimental anniversary falls, as for all Italian Army artillery regiments, on June 15, the beginning of the Second Battle of the Piave River in 1918.

10 cm M. 14 Feldhaubitze
The 10 cm M. 14 Feldhaubitze (Škoda houfnice vz 14) was a dual-purpose field and mountain gun used by Austria-Hungary during World War I, with variations of the 14 and improved 14/19 used by several countries afterwards, especially Italy. It was a conventional design, although the first versions used an obsolescent wrought bronze barrel liner and a cast bronze jacket. Later versions used a standard steel barrel.
Manganui River (Northland)
New Zealand's largest Manganui River is a river of the Northland Region of New Zealand's North Island. It follows a generally westward course from its sources west of Ruakaka before its outflow into the Wairoa River 5 kilometres (3 mi) east of Dargaville. The river's lower course is noted for its convoluted, winding path through low-lying swampy terrain, and several oxbow lakes are associated with this stretch of the river.

Northland Region
Northland (Māori: Te Tai Tokerau), officially the Northland Region, is the northernmost of New Zealand's 16 local government regions. The region is known for its warm weather. The major population centre is the city of Whangārei, and the largest town is Kerikeri. At the 2018 New Zealand census, Northland recorded a population growth spurt of 18.1% since the previous 2013 census, placing it as the fastest growing region in New Zealand, ahead of other strong growth regions such as the Bay of Plenty Region (2nd with 15%) and Waikato (3rd with 13.5%).
Give It to the Thoth Boys – Live Oddities
Give It to the Thoth Boys – Live Oddities is a live recording of Robyn Hitchcock and the Egyptians recorded in 1991 and 1992 at various locations. It was released on cassette only and sold on the Respect tour in 1993. It was compiled by Andy Metcalfe from soundboard tapes done by the band themselves. There is a companion cassette released of the reformed Soft Boys tour called "Where Are The Prawns?".

Soundboard recording
A soundboard recording is a sound recording of a concert taken from a direct connection to the soundboard at the venue. Soundboard recordings are considered to be among the highest quality bootleg recordings of live performances though some soundboard recordings may have an off-balance audio mix.

Because access is required to sensitive equipment to make the recording, most soundboard recordings are authorized in some way either through a liberal policy on the part of the artists or specific permission granted to production staff. Though many soundboard recordings are only available as bootlegs, some are eventually released as legitimate live albums.
Rupert Shrive
Rupert Shrive (born 1965) is an English artist who was born in West Runton.

His interest in art started at the age of six, copying Uccello's Saint George and the Dragon.  He attended Norwich School of Art, St Martin's School of Art and the Slade School of Fine Art in London. He had a studio above the Coach and Horses in Soho for five years, where he met Francis Bacon.  Among his subjects was Soho Pam, a homeless beggar who peddled copies of his watercolour portrait of her.

He lived for many years in Spain and Italy before settling in Paris. His work has been exposed at the Courtauld Institute in London and the Maison de Balzac in Paris. The film, I Love Paris, based on a poem by Rufo Quintavalle, was shot on location in and around his Montmartre atelier in 2024.

Coach and Horses, Soho
The Coach and Horses at 29 Greek Street on the corner with Romilly Street in Soho, London, is a grade II listed public house.

In the 20th century the pub became notable for its association with the columnist Jeffrey Bernard, the staff of Private Eye magazine, other journalists and as a haunt for Soho personalities. Through their writings its former landlord, Norman Balon, became known as "London's rudest landlord".
Edward Whately
Edward William Whately (1823–1892) was an Irish Anglican priest: Archdeacon of Glendalough from 1858 to 1862; and Chancellor of St Patrick's Cathedral, Dublin from 1862 to 1872.

The son of Richard Whately, Archbishop of Dublin from 1831 to 1863, he was born in Halesworth and educated at Rugby School and Christ Church, Oxford, where he matriculated in 1841 and graduated B.A. in 1845. He held, at various times, incumbencies at Chillenden, Bray, Dublin (where he was rector of St. Werburgh), and Littleton.

Whately married, on 25 July 1849 in Edinburgh, Leslie-Anne Fraser from Roxburghshire.

His son Herbert Whately was Archdeacon of Ludlow from 1939 until 1946.

Littleton, Spelthorne
Littleton is a village in the borough of Spelthorne, approximately 16 mi (26 km) west of central London. Historically part of the county of  Middlesex, it was transferred to Surrey in 1965. It is the location of Shepperton Studios.

The village is separated from Shepperton by the River Ash, which runs along its southern boundary. Queen Mary Reservoir, built in 1931, is to the north. Littleton borders Laleham to the west and Charlton, which is also in the post town of Shepperton, is 0.5 miles (800 m) to the north-east. The parish church of St Mary Magdalene is a Grade I listed building.

London Heathrow Airport is 5 miles (8 km) north of Littleton. The nearest railway station is Shepperton.
Muldrow (surname)
Muldrow is a surname. Notable people with the surname include:

Georgia Anne Muldrow (born 1983), American musician

Henry L. Muldrow (1837–1905), American politician

Michelle Muldrow (born 1968), American painter

Robert Muldrow (1864–1950), American geologist

Ronald Muldrow (1949–2007), American guitarist

Sam Muldrow (born 1988), American basketball player

W. Stephen Muldrow (born 1964), American lawyer

Sam Muldrow
Sam Muldrow (born June 8, 1988) is an American professional basketball player for the Windsor Express of the National Basketball League of Canada (NBLC). He played college basketball for South Carolina.

He played 4 seasons of college basketball at the University of South Carolina, with the South Carolina Gamecocks. In March 2011, he was named SEC Defensive Player of the Year.
Tosi (Nepal)
Tosi is a village in Achham District in the Seti Zone of western Nepal. At the time of the 1991 Nepal census, the village had a population of 1962 living in 355 houses. At the time of the 2001 Nepal census, the population was 2015, of whom 33% were literate.

Seti Zone
Seti (Nepali: सेती अञ्चलListenⓘ) was one of the fourteen zones located in the Far-Western Development Region of Nepal. Dhangadhi in the Terai is the major city of Seti Zone; headquarters are in Dipayal-Silgadhi. As of 2015, Nepal discontinued zone designations in favor of provinces; the area previously known as Seti Zone is now part of Sudurpashchim Province.
1980 Amateur World Series
The 1980 Amateur World Series was the 26th Amateur World Series (AWS), an international men's amateur baseball tournament. The tournament was sanctioned by the International Baseball Federation (which titled it the Baseball World Cup as of the 1988 tournament). The tournament took place in Japan, the first time outside the Americas or Europe, from August 22 to September 5, and was won by Cuba – its 16th AWS victory.

There were 12 participating countries.

1988 Baseball World Cup
The 1988 Baseball World Cup (BWC) was the 30th international Men's amateur baseball tournament. The tournament was sanctioned by the International Baseball Federation, which titled it the Amateur World Series from the 1938 tournament through the 1986 AWS. The tournament took place, for the second time, in Italy, from August 23 to September 7, and was won by Cuba – its 19th overall victory (their first under the BWC name).

There were 12 participating countries.

The next nine competitions were also held as the BWC tournament, then was replaced in 2015 by the quadrennial WBSC Premier12.
La Doré
La Doré (French pronunciation: [la dɔʁe]; known as Notre-Dame-de-la-Doré before 1983) is a parish municipality in Quebec, Canada, in the regional county municipality of Le Domaine-du-Roy and the administrative region of Saguenay–Lac-Saint-Jean.

It is located along the banks of the Sauger River (Rivière au Doré), between the Ashuapmushuan River and the Laurentian Mountains to the south, in the geographic township of Dufferin.

Saint-Félicien, Quebec
Saint-Félicien (French pronunciation: [sɛ̃ felisjɛ̃] ⓘ) is a city in the Canadian province of Quebec. The town is located within the Le Domaine-du-Roy Regional County Municipality in the Saguenay-Lac-Saint-Jean region. Its population as of 2021 is 10,089.
1969 European Baseball Championship
The 1969 European Baseball Championship was held in Wiesbaden, Germany and was won by the Netherlands. Italy finished as runner-up. The tournament, held at Lindsey Air Station, had two groups, with defending champion Belgium and Italy and the Netherlands, who both skipped the 1967 championship, in the top group and four teams in the bottom group. West Germany defeated Belgium in the only cross-group game in the tournament. After the tournament, Spain, which went undefeated in the lower group, requested that the two-tiered format be abolished.

An American military team, the Wiesbaden Flyers, and a team from South Africa also attended the tournament.

Italian players reportedly chanted "Antilles, Antilles," objecting to the Dutch team's use of ballplayers from the Netherlands Antilles, which included most valuable player Hamilton Richardson.

South Africa national baseball team
The South African national baseball team is the baseball team which represents the Republic of South Africa in international baseball competitions such as the World Baseball Classic and the Summer Olympics. The governing body of the team is the South African Baseball Union.
Kansas City and Cameron Railroad
The Kansas City and Cameron Railroad was a subsidiary railroad. The railroad was the subsidiary of the Hannibal and St. Joseph Railroad which built the first bridge across the Missouri River at the Hannibal Bridge.

The bridge established Kansas City, Missouri rather than Leavenworth, Kansas or St. Joseph, Missouri as the dominant city in the region.

The Hannibal and St. Joseph was the first railroad to cross the state of Missouri and it carried mail for the Pony Express.  However, when it was time to build a bridge across the river, Robert T. Van Horn, Kersey Coates and Charles E. Kearney put together a package to persuade the railroad to create a cutoff 50 miles east of St. Joseph at Cameron, Missouri to go to Kansas City to hook up with lines going on to Texas.   Kearney was the subsidiary's first president.

Robert T. Van Horn
Robert Thompson Van Horn (May 19, 1824 – January 3, 1916) was an American lawyer, the owner and publisher of The Kansas City Enterprise, the 6th mayor of Kansas City, Missouri during parts of the Civil War, a member of the Missouri General Assembly, and a representative of Missouri's 5th, 6th, and 8th congressional districts.
Seaside Siren Roller Girls
The Seaside Siren Roller Girls (SSRG) was a roller derby league based in Southend-on-Sea, Essex, in England. Founded in 2009, the league consists of two teams, which compete against teams from other leagues. Seaside is a member of the Women's Flat Track Derby Association (WFTDA).

Roller derby
Roller derby is a roller skating contact sport played on an oval track by two teams of five skaters. It is played by approximately 1,250 amateur leagues worldwide, though it is most popular in the United States.

A 60-minute roller derby game, or bout, is a series of two-minute timed jams.  Each team, typically with a roster of 15, fields five skaters during each jam: one jammer, designated with a star on their helmet, and four blockers. During each jam, players skate counterclockwise on a circuit track. The jammer scores a point for each opposing blocker they lap. The blockers simultaneously defend by hindering the opposing jammer, while also playing offense by maneuvering to aid their own jammer. Because roller derby uses a penalty box, power jams, in which one team has a temporary numerical advantage after a foul, can have a major effect on scoring.
Mikael Saha
Mikael Saha (born March 5, 1995) is a Finnish ice hockey player. He is currently playing with Kiekko-Vantaa in the Finnish Mestis.

Saha made his Liiga debut playing with Ässät during the 2014–15 Liiga season.

Mestis
Mestis (from Finnish: Mestaruussarja, meaning 'Championship series', stylized as MEST1S) is the second-highest men's ice hockey league in Finland. The league was established by the Finnish Ice Hockey Association in 2000 to replace the I-divisioona ('First Division').

Promotion to the SM-liiga is achievable for a Mestis team if it defeats an SM-liiga club in the qualification series and meets all the criteria established by the SM-liiga. However, Mestis is an open league that allows for relegation and promotion with the third league, Suomi-sarja.

Mestis is also the highest league under the governance of the FIHA.
The Woman in Cabin 10 (film)
The Woman in Cabin 10 is a 2025 psychological thriller film directed by Simon Stone and Farhan Rana Rajpoot, who co-wrote the screenplay with Joe Shrapnel and Anna Waterhouse, based on the 2016 novel by Ruth Ware. The film stars Keira Knightley, Guy Pearce, Art Malik, Gugu Mbatha-Raw, Kaya Scodelario, Daniel Ings and Hannah Waddingham.

Netflix released The Woman in Cabin 10 on October 10, 2025 to mostly middling and poor responses from critics.

Art Malik
Athar ul-Haque Malik (Urdu: اطہر الحق ملک; born 13 November 1952), known as Art Malik, is a British-Pakistani actor. He achieved international fame in the 1980s through his starring and supporting roles in assorted British television serials and films. His breakout role was as Hari Kumar in the television serial The Jewel in the Crown (1984), which earned him a British Academy Television Award nomination for Best Actor.

Malik starred as Zubin Khan on the BBC One medical drama Holby City (2003–2005), Francesc Gacet on Borgia (2011–2014), and Bunny Latif on Homeland (2014–2020). He is also well-known for his roles as Kamran Shah in the James Bond film The Living Daylights (1987) and the villain Salim Abu Aziz in the action comedy film True Lies (1994).
Eleanor Rieffel
Eleanor Gilbert Rieffel (born 1965) is a mathematician interested in quantum computing, computer vision, and cryptography. She is a senior research scientist at NASA's Ames Research Center.

Rieffel earned her Ph.D. in 1993 from the University of California, Los Angeles. Her dissertation, Groups Coarse Quasi-Isometric to the Hyperbolic Plane Cross the Real Line, concerned geometric group theory, and was supervised by Geoffrey Mess. After working for FX Palo Alto Laboratory, she joined NASA in 2012. In 2019 she won the NASA Exceptional Engineering Achievement Medal.

With Wolfgang Polak, Rieffel is the author of the book Quantum Computing: A Gentle Introduction (MIT Press, 2011).

NASA Exceptional Engineering Achievement Medal
The NASA Exceptional Engineering Achievement Medal (abbreviated EEAM) was established by NASA in 1981 to recognize unusually significant engineering contributions towards achievement of aeronautical or space exploration goals. This award is given for individual efforts for applications of engineering principles or methods that have resulted in a contribution of fundamental importance in this field or have significantly enhanced understanding of this field or have significantly advanced the state of the practice as demonstrated by an application to aerospace systems.
The Ghost of Cain
The Ghost of Cain is the third studio album by the English rock band New Model Army. Released in 1986, The Ghost of Cain propelled the band to the forefront of the alternative rock scene in the 1980s. Not least thanks to the widely acclaimed underground hit song, "51st State", which is the only song by the band to date to feature lyrics not written by the band themselves; the lyrics were written by Ashley Cartwright of The Shakes.

It was the first album to feature new bassist, Jason 'Moose' Harris. It also features former Nine Below Zero member Mark Feltham as a guest musician on harmonica on songs "Poison Street" and "Ballad".

Brazilian thrash metal band Sepultura covered the song "The Hunt" on their 1993 album, Chaos A.D. UK folk metal band Skyclad covered the song "Master Race" on their Oui Avant-Garde á Chance album in 1996.

Chaos A.D.
Chaos A.D. is the fifth studio album by Brazilian heavy metal band Sepultura, released in 1993 by Roadrunner Records. After the success of Arise (1991), the band decided to expand the experimentation of that album and depart further from their earlier thrash metal sound, moving towards groove metal. The album also features the band's first fully acoustic song.

Chaos A.D. is also Sepultura's only album on Epic Records, which handled its release for North American distribution. It is also the first album to feature Paulo Jr. on bass after having played with the band in a live capacity since 1984.

The album peaked at 32 on the Billboard 200, becoming Sepultura's highest charting record at the time and Roadrunner's first album in the top 40. It received widespread acclaim upon release and has come to be regarded as one of Sepultura's best albums, and a landmark in heavy metal.
WWE 2K23
WWE 2K23 is a 2023 professional wrestling sports video game developed by Visual Concepts and published by 2K. It is the twenty-third overall installment of the video game series based on WWE, the ninth game under the WWE 2K banner, and the successor to WWE 2K22. It was released on March 14, 2023, for PlayStation 4, PlayStation 5, Windows, Xbox One, and Xbox Series X/S.

WWE 2K23 received generally favorable reviews upon release, and it is the highest-rated professional wrestling video game since WWE '13. The follow-up title, WWE 2K24, was released on March 8, 2024. The online servers for WWE 2K23 were shut down on January 6, 2025.

2K (company)
2K is an American video game publisher based in Novato, California. The company was founded as a subsidiary of Take-Two Interactive in January 2005 through the 2K Games and 2K Sports sub-labels. The nascent label incorporated several development studios owned by Take-Two, including Visual Concepts and Kush Games, which had been acquired the day before. Originally based in New York City, 2K moved to Novato in 2007. A third label, 2K Play, was added in September 2007. 2K is governed by David Ismailer as president and Phil Dixon as chief operating officer. It operates a motion capture studio in Petaluma, California.
Great Lakes Basin Railroad
The Great Lakes Basin Railroad is a proposed railroad in Wisconsin, Illinois, and Indiana. The intended route bypasses Chicago to avoid its rail congestion, running from Janesville, Wisconsin, to Michigan City, Indiana. The project's estimated cost is $8 billion, privately financed.

On May 1, 2017, the Great Lake Basin Railroad filed its construction application with the Surface Transportation Board. On August 30, 2017, the Surface Transportation Board unanimously rejected GLB's application.

Michigan City, Indiana
Michigan City is a city in LaPorte County, Indiana, United States. It had a population of 32,075 at the 2020 census. Located along Lake Michigan in the Michiana region, the city is about 45 miles (72 km) east of Chicago and is 40 miles (64 km) west of South Bend.

Michigan City is noted for both its proximity to Indiana Dunes National Park and for bordering Lake Michigan. It receives a fair amount of tourism during the summer, especially by residents of Chicago and nearby cities in Northern Indiana. It is connected to Chicago via the South Shore Line passenger train.
Flavio Biondo
Flavio Biondo (Latin Flavius Blondus) (1392 – June 4, 1463) was an Italian Renaissance humanist historian. He was one of the first historians to use a three-period division of history (Ancient, Medieval, Modern) and is known as one of the first archaeologists. 
Born in the capital city of Forlì, in the Romagna region, Flavio was well schooled from an early age, studying under Ballistario of Cremona. During a brief stay in Milan, he discovered and transcribed the unique manuscript of Cicero's dialogue Brutus. He moved to Rome in 1433 where he began work on his writing career; he was appointed secretary to the Cancelleria under Pope Eugene IV in 1444 and accompanied Eugene in his exile in Ferrara and Florence. After his patron's death, Flavio was employed by his papal successors, Nicholas V, Callixtus III and the humanist Pius II.

Apostolic Chancery
The Apostolic Chancery (Latin: Cancellaria Apostolica; also known as the "Papal" or "Roman Chanc(ell)ery") was a dicastery of the Roman Curia at the service of the pope. The principal and presiding official was the Grand Chancellor of the Holy Roman Church, who was always the cardinal-priest of the Basilica di San Lorenzo in Damaso. The  principal function of the office was to collect money to maintain the Papal army and to produce documents and correspondence for the pope. Pope Pius VII reformed the office when Emperor Napoleon I of France obviated the need for Papal armies. In the early 20th century the office collected money for missionary work. Pope Paul VI abolished the Apostolic Chancellary on 27 February 1973, transferring its functions to the Secretariat of State.