hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
RO4491533
RO-4491533 is a drug developed by Hoffmann-La Roche which acts as a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3), being equipotent at mGluR2 and  mGluR3 but without activity at other mGluR subtypes. In animal studies, RO-4491533 produced antidepressant effects and reversed the effects of the mGluR2/3 agonist LY-379,268 with similar efficacy but slightly lower potency than the mGluR2/3 antagonist LY-341,495. A number of related compounds are known, with similar effects in vitro and a fairly well characterized structure-activity relationship.

Potency (pharmacology)
In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity. A highly potent drug (e.g., fentanyl, clonazepam, risperidone, benperidol, bumetanide) evokes a given response at low concentrations, while a drug of lower potency (e.g. morphine, diazepam, ziprasidone, haloperidol, furosemide) evokes the same response only at higher concentrations. Higher potency does not necessarily mean greater effectiveness nor more side effects nor less side effects.
Gabriel Barcia-Colombo
Gabriel Barcia-Colombo (born 1982) is an American video artist and filmmaker. His video sculpture installations explore themes of memory, identity, and human connection through a combination of video, photography, and video sculpture.

Barcia-Colombo is the grandson of Spanish poet and writer José Rubia Barcia.

José Rubia Barcia
José Rubia Barcia (1914–1997) was born in Ferrol (Galicia), where a cultural center dedicated to him now houses his library and a collection of his papers. He studied Arabic and Hispano-Arabic literature at the University of Granada. After completing his degree he held important positions in the Spanish Republican Army during the Spanish Civil War and as a consequence he went into exile, first to France and then to Cuba and then to the United States. Here he worked in Hollywood with the Spanish film director Luis Buñuel. Rubia Barcia published a great number of books and articles on Valle Inclán, Unamuno, Federico García Lorca and other writers of the 20th century. He was also an author of political essays.

Rubia and Clayton Eshleman jointly prepared The Complete Posthumous Poetry of César Vallejo (1978) and won the U.S. National Book Award, category Translation.
Simona Dobrá
Simona Dobrá (born 24 June 1987) is a retired Czech tennis player.

Dobrá won two singles and 21 doubles titles on the ITF Women's Circuit in her career. On 15 September 2008, she reached her best singles ranking of world No. 514. On 8 June 2009, she peaked at No. 241 in the doubles rankings.

In June 2008, partnering Tereza Hladíková, Dobrá won the $75k tournament in Zlín, defeating Lucie Hradecká and Renata Voráčová in the final.

Dobrá retired from tennis 2012.

Zlín
Zlín (in 1949–1989 Gottwaldov; Czech pronunciation: [zliːn]; German: Zlin) is a city in the Czech Republic. It has about 75,000 inhabitants. It is the seat of the Zlín Region and it lies on the Dřevnice River. It is known as an industrial centre. The development of the modern city is closely connected to the Bata Shoes company and its social scheme, developed after World War I. A large part of Zlín is urbanistically and architecturally valuable and is protected as an urban monument zone.
Ebet Kadarusman
Ebet Kadarusman (July 7, 1936 – March 20, 2010) was an Indonesian television and radio presenter and host. He was known to audiences for the phrase, "It is nice to be important, but it is more important to be nice", which he used on his television talk show, Salam Canda.

Radio personality
A radio personality is a person who has an on-air position in radio broadcasting. A radio personality who hosts a radio show is also known as a radio host (North American English), radio presenter (British English) or radio jockey. Radio personalities who introduce and play individual selections of recorded music are known as disc jockeys or "DJs" for short. Broadcast radio personalities may include talk radio hosts, AM/FM radio show hosts, and satellite radio program hosts, and non-host contributors to radio programs, such as reporter
Agios Vasileios, Laconia
Agios Vasileios (also spelled Ayios Vasileios or Ayios Vasilios; Greek: Άγιος Βασίλειος) is the site of a Mycenaean palace, located 4 kilometers east of the village of Xirokambi in Laconia, Greece. It was west of the Eurotas River commanding the plain, some 10 km south of Sparta.
The site is cut by the modern Sparta--Gytheio national road. It is named after a chapel by the side of the road.

Laconia
Laconia or Lakonia (Greek: Λακωνία, Lakonía, [lakoˈni.a]) is a historical and administrative region of Greece located on the southeastern part of the Peloponnese peninsula. Since 2011, it has been administered as a regional unit, with Sparta as its capital. The word laconic—to speak in a blunt, concise way—is probably derived from the name of this region, a reference to the ancient Spartans who were renowned for their verbal austerity and blunt, often pithy remarks.
Khmost
The Khmost (Russian: Хмость) is a river in Dukhovshchinsky, Smolensky, and Kardymovsky Districts of Smolensk Oblast, Russia, a right tributary of the Dnieper. The length of the river is 135 kilometres (84 mi), and the area of its drainage basin is 636 square kilometres (246 mi2). The settlement of Kardymovo is located near the river mouth.

The source of the Khmost is in the west of Dukhovshchina District, north of the village of Vasino. It flows south and downstream of the village of Botino makes the border between Dukhovshchinsky and Smolensky Districts. A short stretch of the river crosses Smolensky District, then the river turns east and forms the border between Dukhovshchinsky and Kardymovsky Districts. In the village of Lisichino, it departs from the border and flows southeast through Kardymovsky District. The mouth of the Khmost is south of the village of Ryzhkovo.

Smolensk Oblast
Smolensk Oblast (Russian: Смоленская область, romanized: Smolenskaya oblastʹ), informally also called Smolenshchina (Смоленщина), is a federal subject of Russia (an oblast). Its administrative centre is the city of Smolensk. As of the 2021 Census, its population was 888,421.
2009 Washington Referendum 71
The 2009 Washington Referendum 71 (R-71) was a state referendum that legalized domestic partnership in Washington state, the first statewide referendum in the United States that extended to LGBT people the rights and responsibility of domestic partnership.  The bill had passed State Legislature, and it was signed into law by the Governor in May 2009, but opponents gathered enough signatures to put the measure before the voters, who returned ballots by mail over three weeks ending on November 3, 2009, approving the measure 53% to 47%. The new law went into effect 30 days later, on December 3, 2009.

Prior to this Washington state vote, a ban on same-sex marriages and civil unions, Arizona Proposition 107, was rejected by voters in that state in 2006, who two years later passed the civil-unions-neutral Arizona Proposition 102.

2008 Arizona Proposition 102
Arizona Proposition 102 was an amendment to the constitution of the U.S. state of Arizona adopted by a ballot measure held in 2008. It added Article 30 of the Arizona Constitution, which says: "Only a union of one man and one woman shall be valid or recognized as a marriage in this state." The amendment added a constitutional ban on same-sex marriage to existing statutory bans in place since 1996.

In October 2014, Article 30 of the Arizona Constitution was struck down as federally unconstitutional in the United States District Court for the District of Arizona, and is no longer enforced by the state of Arizona, which subsequently allows and recognizes same-sex marriages.

Despite the court ruling, Article 30 remains in the state's constitution, and on the Arizona State Legislature's website there is no indication that Article 30 of the constitution was struck down or otherwise rendered inoperative.
Harald Agger
Harald Agger (11 April 1889 – 20 May 1954) was a Danish athlete who competed in the hammer throw, shot put, discus throw, high jump, and pole vault. He was a multiple-time Danish Athletics Championships winner and competed in the men's hammer throw at the 1908 Summer Olympics.

Athletics at the 1908 Summer Olympics – Men's hammer throw
The men's hammer throw was one of six throwing events on the Athletics at the 1908 Summer Olympics programme in London. The competition was held on July 14, 1908. 19 throwers from eight nations competed. NOCs could enter up to 12 athletes. The event was won by American John Flanagan, his third consecutive victory in the event. He was the first man to win three medals in the hammer throw and, as of the 2016 Games, the only one to win three gold medals in the event. The silver medal went to fellow American Matt McGrath. Con Walsh of Canada took bronze and became the first athlete not from the United States to win a medal in the event, as the Americans had swept the podium in both 1900 and 1904. The three medalists were all part of the Irish Whales.
Velvet Empire
Velvet Empire was a Canadian pop music group that was formed through the second edition of the Global TV show Popstars, entitled "Boy Meets Girl". The group was formed in Spring 2002. They recorded their first and only album in Toronto at Metalworks Recording Studio.

The group were winners of a 10-month competition, intended to form a pop group comprising both males and females. Its members were Alex Price, Justin Humes, Janelle Belgrave, Lacey Block and Ryan Hamilton. The new group called itself Velvet Empire and released an album, Velvet Empire, and single, "Frontin' On Me", in 2002. Despite the single receiving much radio and video play, the album's sales were not as expected. As a result, the group disbanded by 2003.

Popstars
Popstars is an international reality television franchise aimed to find new singing talent. Serving as a precursor to the Idol franchise, Popstars first began in New Zealand in 1999 when producer Jonathan Dowling formed the girl group TrueBliss. Despite all shows in the Popstars franchise having been off air in recent years, it remains one of the most successful TV show formats of all time with the format being sold to more than 50 countries and producing groups such as Girls Aloud that had success on the UK charts for the next ten years after winning. The show was the inspiration for Simon Fuller's Idol franchise.
Northmor High School
Northmor High School is a public high school in North Bloomfield Township, south of Galion, Ohio, United States. It was founded in 1963 and is the only high school in the Northmor Local School District. Athletic teams are known as the Golden Knights and school colors are black, gold, and white. It is housed in the Northmor K–12 building, which opened in August 2011 and also includes Northmor Elementary School and Northmor Junior High School. While the schools share common areas and the high school and junior high share the same bell schedule, they are administered separately.

The first graduating class was in 1964. The name "Northmor" is a portmanteau from the school district being located in northern Morrow County.

Galion, Ohio
Galion (/ˈɡæljən/ GAL-yən) is a city in Crawford, Morrow, and Richland counties in the U.S. state of Ohio. The population was 10,453 at the 2020 census. Galion is the second-largest city in Crawford County after Bucyrus.

The Crawford County portion of Galion is part of the Bucyrus micropolitan statistical area. The small portion of the city that is located in Richland County is part of the Mansfield metropolitan area, while the portion extending into Morrow County is considered part of the Columbus, Ohio metropolitan area.
Júlia Gusztinyi
Júlia Gusztinyi (born? — died 1849, Cluj) was a Hungarian actress and opera singer who had a prominent stage career in Eastern Europe during the 1840s. She mainly portrayed roles from the soubrette repertoire and other lighter roles for soprano. She made her debut as an actress at the National Theatre, Budapest in 1840, and was active at that theatre during the early 1840s in plays and operas. For part of her career, she was a member of theatre impresario József Szákfy's company of actors. She appeared in theatres in Subotica (1844), Oradea (1845), Zrenjanin (1847), and Cluj (1848-1849). She was married in Cluj shortly before her death there in 1849. Her stage repertoire included the roles of Gianetta in Donizetti's L'elisir d'amore, Marie in Donizetti's The Daughter of the Regiment, and Zsuzsi in Ede Szigligeti's A rab, szerző among other roles.
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National Theatre (Budapest)
The National Theatre, located in Budapest originally opened in 1837. Since then, it has occupied several locations, including the original building at Kerepesi Street, the People's Theatre at Blaha Lujza Square, as well as Hevesi Sándor Square, its longest temporary location. It currently occupies the National Theatre building, which opened March 15, 2002.
Cobitis minamorii
Cobitis minamorii is a species of fish in the family Cobitidae found in Honshu, Japan. Five subspecies have been proposed. Japanese name is kogata-suji-shima-dojyô. English name is Small stripe spined loach. This species is listed as a new species in 2012.

They inhabit sandy-mud bottoms of the lower reach of rivers and small lowland stream. The number of current population is decreasing because these habitable environment is decreasing. They are found in  western Honshu:Okayama, Shimane, Tottori, Hiroshima, Hyogo, Osaka, Kyoto, Shiga, Mie, Gihu, Aichi, Shizuoka.

Their spawning season is May-August. They invade a temporary wetland such as rice field and lay eggs at the bottom of the mud. These eggs hatch during one day. They mature in one year and live in approximately 3-5 years under breeding. They grow up to 10 cm in total length. Minamorii, their specific name, comes from Japanese researcher who study speciation of Japanese loaches first.

Okayama Prefecture
Okayama Prefecture (岡山県, Okayama-ken; Japanese pronunciation: [o.kaꜜ.ja.ma, o.ka.ja.maꜜ.keɴ]) is a prefecture of Japan located in the Chūgoku region of Honshu. Okayama Prefecture has a population of 1,815,165 (1 October 2025) and has a geographic area of 7,114 km2 (2,746 sq mi). Okayama Prefecture borders Tottori Prefecture to the north, Hyōgo Prefecture to the east, and Hiroshima Prefecture to the west.

Okayama is the capital and largest city of Okayama Prefecture, with other major cities including Kurashiki, Tsuyama, and Sōja. Okayama Prefecture's south is located on the Seto Inland Sea coast across from Kagawa Prefecture on the island of Shikoku, which are connected by the Great Seto Bridge, while the north is characterized by the Chūgoku Mountains.
Benitochromis
Benitochromis is a small  genus of cichlid fishes that are endemic to riverine and lake habitats in Middle Africa (Cameroon and Equatorial Guinea, including the island of Bioko). Several of these species were originally assigned to the genus Chromidotilapia. The name of this genus is derived from the type locality of the Benito River in Equatorial Guinea compounded with chromis, a word which originated with Aristotle and which may derive from the Greek word chroemo, meaning "to neigh" and which may have originally referred to the drums of the family Sciaenidae and which was expanded to include cichlids, damselfishes, dottybacks, and wrasses, groups of perch-like fish which were thought to be more closely related to each other than they are subsequent studies have apparently found them to be.

Sciaenidae
Sciaenidae is a family of ray-finned fishes belonging to the order Acanthuriformes. They are commonly called drums or croakers in reference to the repetitive throbbing or drumming sounds they make. The family consists of about 293 to 298 species in about 66 or 67 genera.
Linwell
Linwell (foaled 1948) was an Irish-bred, British-trained Thoroughbred racehorse who won the 1957 Cheltenham Gold Cup. Originally named Floral Tribute he was imported to England in 1953 and was trained by the journalist Ivor Herbert for the businessman David Brown. After beginning his career in point-to-point races he made rapid progress when switched to professional steeplechasing winning the Mildmay Memorial Chase in 1956 and the Gold Cup in the following year. In two subsequent attempts at the Gold Cup he had little luck: he unseated his jockey when hampered by a falling rival in 1958 and finished second in 1959 after being badly baulked and almost brought down at the final fence.

Champion Hurdle
The Champion Hurdle is a Grade 1 National Hunt hurdle race in Great Britain which is open to horses aged four years or older. It is run on the Old Course at Cheltenham over a distance of about 2 miles and ½ furlong (2 miles and 87 yards or 3,298 metres), with eight hurdles to be jumped. The most prestigious hurdling event in the British calendar, its list of winners features many of the most highly acclaimed hurdlers in the sport's history. The Champion Hurdle is scheduled to take place each year on the opening day of the Cheltenham Festival in March and is the last leg of the Triple Crown of Hurdling. As part of a sponsorship agreement with the online gambling operator Unibet, the race is now known as the Unibet Champion Hurdle.
Hasselblad
Victor Hasselblad AB is a Swedish manufacturer of medium format cameras, photographic equipment and image scanners based in Gothenburg, Sweden. The company originally became known for its classic analog medium-format cameras that used a waist-level viewfinder. Perhaps the most famous use of the Hasselblad camera was during the Apollo program missions when the first humans landed on the Moon. Almost all of the still photographs taken during these missions used modified Hasselblad cameras. In 2016, Hasselblad introduced the world's first digital compact mirrorless medium-format camera, the X1D-50c, changing the portability of medium-format photography. Hasselblad produces about 10,000 cameras a year from a small three-storey building.

Focal-plane shutter
In camera design, a focal-plane shutter (FPS) is a type of photographic shutter that is positioned immediately in front of the focal plane of the camera, that is, right in front of the photographic film or image sensor.
Dave Riley
David Michael Riley (July 30, 1960 – December 24, 2019) was an American musician who was the bassist in the punk rock band Big Black from 1985 until the band's dissolution in 1987. Riley moved to Chicago in 1982 from Detroit, where he had worked as a recording engineer. He played on Big Black's two studio albums, Atomizer (1986) and Songs About Fucking (1987), as well as their Headache EP (1987), several singles, and two live albums.

After Big Black, Riley recorded tracks with several other artists before being incapacitated by a stroke in 1993, losing the ability to walk. He became a blogger, and published a book in 2006 titled Blurry and Disconnected: Tales of Sink-or-Swim Nihilism. He died in late 2019 from squamous cell carcinoma.

Bassist
A bassist (also known as a bass player or bass guitarist) is a musician who plays a bass instrument such as a double bass (upright bass, contrabass, wood bass), bass guitar (electric bass, acoustic bass), keyboard bass (synth bass) or a low brass instrument such as a tuba or trombone. Many musical genres tend to be associated with at least one or more of these instruments.
Kidnapping of Shahbaz Taseer
Shahbaz Taseer is a Pakistani businessman, and the son of the former Governor of Punjab (Pakistan) Salman Taseer. In August 2011, following his father's assassination, he was kidnapped by militants in Lahore while he was driving to his office from home. Taseer was held in captivity for around four and a half years and was recovered from Kuchlak, Balochistan on 8 March 2016. Taseer's kidnapping was referred as one of the most high-profile kidnappings in Pakistan by The Guardian. BBC's HARDtalk interviewed Taseer about his days in captivity. In an interview, he mentioned that he was held by Uzbek militants, before eventually being passed to the Taliban.

Governor of Punjab, Pakistan
The governor of Punjab (Punjabi/Urdu: گورنر پنجاب, romanized: Gavarnar Panjāb) is the head of province of the Pakistani province of Punjab. Appointed by the federal government through the president of Pakistan, the governor serves a nominal and ceremonial role as head of province and executive, with real executive authority exercised by the elected chief minister and their appointed cabinet; and administrative authority by the chief secretary, the senior-most bureaucrat in the province, who reports to the chief minister.

However, throughout the history of Pakistan, the powers of the provincial governors were vastly increased, when the provincial assemblies were dissolved and the administrative role came under direct control of the governors, as in the cases of martial laws of 1958–1972 and 1977–1985, and governor rules of 1999–2002. In the case of Punjab, there was direct governor rule in 1949–1951, when the provincial chief minister of that time was removed and assemblies dissolved.
Ernstberg
The Ernstberg (also Erresberg) southeast of Hinterweiler is, at 698.8 m, the highest of the west Eifel volcanoes and, after the Hohe Acht, the second highest mountain in the Eifel overall. Its summit consists of pyroclastic rocks (Schweißschlacken) that form a volcanic crater that is open towards the east. This is where the basalt masses flowed out, forming a semicircle on the eastern slope of the mountain. It lies within the Waldeifel region.

In winter there are excellent winter sports conditions on the Ernstberg due to its height. Cut langlauf tracks, a toboggan slope and ski hire hut are available.

Somewhat below the summit is a cave that runs through to the other side of the mountain and which is a natural monument. The cave entrances are barred to prevent access.

Volcanic crater
A volcanic crater is an approximately circular depression in the ground caused by volcanic activity. It is typically a bowl-shaped feature containing one or more vents. During volcanic eruptions, molten magma and volcanic gases rise from an underground magma chamber, through a conduit, until they reach the crater's vent, from where the gases escape into the atmosphere and the magma is erupted as lava. A volcanic crater can be of large dimensions and sometimes of great depth. During certain types of explosive eruptions, a volcano's magma chamber may empty enough for an area above it to subside, forming a type of larger depression known as a caldera.