hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
VU-0238429
VU-0238429 is a drug which acts as a selective positive allosteric modulator for the muscarinic acetylcholine receptor M5. It was the first selective ligand developed for the M5 subtype, and is structurally derived from older M1-selective positive allosteric modulators such as VU-0119498. Replacing the O-methyl- by a phenyl group further improves the receptor subtype selectivity.

Muscarinic acetylcholine receptor M1
The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene. It is localized to 11q13.

This receptor is found mediating slow EPSP at the ganglion in the postganglionic nerve, and is common in exocrine glands and in the CNS.

It is predominantly found bound to G proteins of class Gq that use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signalling pathway. A receptor so bound would not be susceptible to CTX or PTX. However, Gi (causing a downstream decrease in cAMP) and Gs (causing an increase in cAMP) have also been shown to be involved in interactions in certain tissues, and so would be susceptible to PTX and CTX respectively.
Dave Scott (artist)
Dave Scott (born 1994) is an American painter from Trotwood, Ohio known for his colorful paintings. Scott has exhibited work across the United States, including at the Cincinnati Art Museum and the Contemporary Arts Center.

Trotwood, Ohio
Trotwood is a city in Montgomery County, Ohio, United States. The population was 23,070 at the 2020 census. A suburb of Dayton, it is part of the Dayton metropolitan area. The city is served by the Trotwood-Madison City School District.
Alberto Mantovani
Alberto Mantovani Commendatore OMRI (born 29 October 1948) is an Italian physician and immunologist. He is Scientific Director of Istituto Clinico Humanitas (Humanitas Clinical and Research Center), President and Founder of the Fondazione Humanitas per la Ricerca, and Professor of Pathology at the State University of Milan. He is known for his works in the roles of the immune system in the development of cancer. His research on tumor-associated macrophages (TAM, an acronym he coined) established inflammation as one of the causes of cancer. He was the first to identify monocyte chemotactic protein - 1 / CCL2 in 1983, and PTX3 in 1997. His works revealed the existence of decoy receptors in cell-signalling. He has been the most cited scientist in Italy, and one of the ten most cited immunologists worldwide.

Tumor-associated macrophage
Tumor-associated macrophages (TAMs) are a class of immune cells present in high numbers in the microenvironment of solid tumors. They are heavily involved in cancer-related inflammation. Macrophages are known to originate from bone marrow-derived blood monocytes (monocyte-derived macrophages) or yolk sac progenitors (tissue-resident macrophages), but the exact origin of TAMs in human tumors remains to be elucidated. The composition of monocyte-derived macrophages and tissue-resident macrophages in the tumor microenvironment depends on the tumor type, stage, size, and location, thus it has been proposed that TAM identity and heterogeneity is the outcome of interactions between tumor-derived, tissue-specific, and developmental signals.
5ESS Switching System
The 5ESS Switching System is a Class 5 telephone electronic switching system developed by Western Electric for the American Telephone and Telegraph Company (AT&T) and the Bell System in the United States. It came into service in 1982 and the last unit was produced in 2003.

AT&T Corporation
AT&T Corporation, an abbreviation of its former name, the American Telephone and Telegraph Company, was an American telecommunications company that provided voice, video, data, and Internet telecommunications and professional services to businesses, consumers, and government agencies.

During the Bell System's long history, AT&T was at times the world's largest telecommunications company, the world's largest cable television operator, and a regulated monopoly. At its peak in the 1950s and 1960s, it employed one million people and its revenue ranged between US$3 billion in 1950 ($42.6 billion in present-day terms) and $12 billion in 1966 ($120 billion in present-day terms).

In 2005, AT&T was acquired by "Baby Bell" and former subsidiary SBC Communications for more than $16 billion ($25.8 billion in present-day terms). SBC then changed its name to AT&T Inc., with AT&T Corporation continuing to exist as a long-distance calling subsidiary until its dissolution on May 1, 2024.
An Riabhachan
An Riabhachan is a Scottish mountain in the Skye and Lochalsh district of the Highland council area. It is situated 35 kilometres east of Kyle of Lochalsh standing in an isolated position at the western end of Loch Mullardoch, ten kilometres from any public road.

Kyle of Lochalsh
Kyle of Lochalsh (Scottish Gaelic: Caol Loch Aillse [kɯːl̪ˠ l̪ˠɔx ˈaiʎʃə], "strait of the foaming loch") is a village in the historic county of Ross & Cromarty on the northwest coast of Scotland, located around 55 miles (90 km) west-southwest of Inverness. It is located on the Lochalsh peninsula, at the entrance to Loch Alsh, opposite the village of Kyleakin on the Isle of Skye. A ferry used to connect the two villages until it was replaced by the Skye Bridge, about a mile (2 km) to the west, in 1995.
Asif Mumtaz
Asif Mumtaz (born 3 October 1988) is a Pakistani cricketer. He made his first-class debut for Rawalpindi in the 2009–10 Quaid-e-Azam Trophy on 3 December 2009. He made his List A debut for Rawalpindi Rams in the 2010-11 National One Day Championship on 30 January 2011.

Rawalpindi cricket team
Rawalpindi cricket team is a first-class cricket team that represents Rawalpindi, Punjab. The team's home ground is Rawalpindi Cricket Stadium, Rawalpindi. They participate in the Quaid-e-Azam Trophy. They were refounded in the 2023/24 season after a revamp of the domestic structure.
Ellen Gittelsohn
Ellen Gittelsohn (born April 12, 1945, in New York City, New York) is an American television director. She has also been credited under the name Ellen Falcon, despite the popular belief that she and Ellen Falcon are two different people.

Since the 1980s, Gittelsohn has amassed a number of television credits. Some of them include Designing Women, The Cosby Show, A Different World, Newhart, Mary, Foley Square, 227, Roseanne, Major Dad, The Fresh Prince of Bel-Air, Living Single, Friends, Reba, Shake It Up, Two Guys, a Girl and a Pizza Place, Everybody Loves Raymond, Dharma & Greg, One on One, The Suite Life on Deck, and Half & Half.

In 1984, Gittelsohn earned a Primetime Emmy Award nomination for Outstanding Directing for a Comedy Series for the series Buffalo Bill.

Major Dad
Major Dad is an American sitcom television series created by Richard C. Okie and John G. Stephens, developed by Earl Pomerantz, that originally ran from September 17, 1989, to May 17, 1993, on CBS, starring Gerald McRaney as Major John D. MacGillis and Shanna Reed as his wife Polly. The cast also includes Beverly Archer, Matt Mulhern, Jon Cypher, Marisa Ryan, Nicole Dubuc, and Chelsea Hertford.
Stucco
Stucco or render is a construction material made of aggregates, a binder, and water. Stucco is applied wet and hardens to a very dense solid. It is used as a decorative coating for walls and ceilings, exterior walls, and as a sculptural and artistic material in architecture. Stucco can be applied on construction materials such as metal, expanded metal lath, concrete, cinder block, or clay brick and adobe for decorative and structural purposes.

In English, "stucco" sometimes refers to a coating for the outside of a building and "plaster" to a coating for interiors. As described below, however, the materials themselves often have little or no difference. Other European languages, notably Italian, do not have the same distinction: In Italian, stucco means plaster, and serves for both.

Binder (material)
A binder or binding agent is any material or substance that holds or draws other materials together to form a cohesive whole mechanically, chemically, by adhesion or cohesion.

More narrowly, binders are liquid or dough-like substances that harden by a chemical or physical process and bind fibres, filler powder and other particles added into it. Examples include glue, adhesive and thickening.

Examples of mechanical binders are bond stones in masonry and tie beams in timber framing.
Take Care of Us, Captain
Take Care of Us, Captain (Korean: 부탁해요 캡틴; RR: Butakhaeyo kaeptin) is a 2012 South Korean television series starring Koo Hye-sun as a passionate female co-pilot who gets paired with the youngest pilot of a Boeing 747 (played by Ji Jin-hee). It aired on SBS TV from January 4 to March 8, 2012, on Wednesdays and Thursdays at 21:55 for 20 episodes.

SBS TV
SBS TV (Seoul Broadcasting System Television) is a South Korean free-to-air television channel operated by Seoul Broadcasting System. The channel was launched on 9 December 1991. Unlike competing network MBC, SBS operates using a federalized structure, managing a network of nine stations (of which SBS in Seoul is the flagship) to supply programming, while the affiliates outside Seoul carry local programming to cater to local needs.
Troels Lyby
Troels Lyby (born 15 October 1966) is a Danish actor. He made his big break in Hella Joof's film En kort en lang, but had previously acted in Let's Get Lost by Jonas Elmer and Lars von Trier's The Idiots. Since then, he has been in Okay and Jul i Valhal.

Troels Lyby was also in the Danish sitcom Hvor svært kan det være.

He has also played many roles in different theatres, including at the Gasolin' teaterkoncert.

Troels Lyby won the Robertprisen for best supporting actor in 2002 for the film En kort en lang and the Robertprisen for best actor in 2006 for the film Anklaget.

Jonas Elmer (director)
Jonas Elmer (born 14 March 1966) is a Danish film director, screenwriter and previously an actor. In 1988 he was a production assistant at the set of Family Business, starring Sean Connery.

Elmer graduated in direction at the National Film School of Denmark in 1995. His debut as a director came with the Danish film Let's Get Lost which won him a Robert and Bodil Award for Best Danish Film. Since then, he has directed the Danish feature films Monas verden and Nynne. He has also directed 21 episodes of the Danish sit-com Langt fra Las Vegas. He directed his first American feature film in 2008, New in Town, starring Renée Zellweger and Harry Connick, Jr, which was released in January 2009. In 2013 he directed the film In Real Life, a production about human desire to have their unmet needs satisfied, and shows their passions, desperation and delusion.
1908 Newfoundland general election
The 1908 Newfoundland general election was held on November 2, 1908 to elect members of the 21st General Assembly of Newfoundland in the Dominion of Newfoundland. The seats were split evenly between the Liberal Party and the new Newfoundland People's Party formed by Edward Morris after he resigned from the Liberal government in 1907 and joined with the opposition. Robert Bond, the Liberal leader, asked the Governor William MacGregor to dissolve the assembly. MacGregor refused to do this and Bond resigned as Premier. The Governor asked Edward P. Morris to form a government. The assembly was not able to elect a speaker and, after the Governor was unable to convince the two party leaders to form a coalition government, the house of assembly was dissolved on April 9, 1909.

Robert Bond
Sir Robert Bond KCMG PC (25 February 1857 – 16 March 1927) was a Newfoundlander politician who was the last Premier of Newfoundland Colony from 1900 to 1907 and the first prime minister of the Dominion of Newfoundland from 1907 to 1909 after the 1907 Imperial Conference conferred dominion status on the colony.
Mokrousovo
Mokrousovo (Russian: Мокроусово) is the name of several rural localities in Russia:

Mokrousovo, Republic of Bashkortostan, a village in Iskinsky Selsoviet of Ufa, the Republic of Bashkortostan

Mokrousovo, Kemerovo Oblast, a village in Sidorovskaya Rural Territory of Novokuznetsky District of Kemerovo Oblast

Mokrousovo, Kurgan Oblast, a selo in Mokrousovsky Selsoviet of Mokrousovsky District of Kurgan Oblast

Mokrousovo, Kursk Oblast, a village in Podovsky Selsoviet of Khomutovsky District of Kursk Oblast

Mokrousovo, Yaroslavl Oblast, a village in Chebakovsky Rural Okrug of Tutayevsky District of Yaroslavl Oblast

Mokrousovo, Kurgan Oblast
Mokrousovo (Russian: Мокроусово) is a rural locality (a selo) and the administrative center of Mokrousovsky District, Kurgan Oblast, Russia. Population:  4,849 (2010 Census); 4,963 (2002 Census); 5,105 (1989 Soviet census).
Kimberly Joines
Kimberly Joines (born January 27, 1981, in Edmonton) is a Canadian alpine skier. While snowboarding in the year 2000 Kimberly was involved in a snowboarding accident. The accident resulted in spinal cord injuries at the L1/T12 vertebra and consequently she is paralysed from the waist down. She subsequently joined the Canadian para-alpine ski team. She competed in the 2010 Vancouver Paralympics in five events: Downhill (women’s sitting), Super G (Women’s sitting), Super combined (Women’s sitting), giant slalom (Women’s sitting) and Slalom (Women’s sitting).

Joines won a bronze medal at the Torino Paralympic games in 2006. She was suspended in 2007 after being tested positive for marijuana. She also competed in wheelchair basketball at the 2004 Paralympic Games in Athens.

She won Bronze in the Women's slalom, sitting at the 2014 Winter Paralympics.

2006 Winter Paralympics
The 2006 Winter Paralympic Games (Italian: Giochi paralimpici invernali del 2006), the ninth Paralympic Winter Games, took place in Turin, Italy, from 10 to 19 March 2006.  These were the first Winter Paralympic Games to be held in Italy. They were also the first Paralympics to use the new Paralympics logo.

20 years later, Italy will host the Winter Paralympics again in 2026, scheduled to be held in Milan and Cortina d'Ampezzo.
First Love Sisters
First Love Sisters (Japanese: 初恋姉妹, Hepburn: Hatsukoi Shimai) is a Japanese manga written by Mako Komao and illustrated by Mizuo Shinonome (characters) and Reine Hibiki (scenario) which was first serialized in the now-defunct yuri josei manga magazine Yuri Shimai on June 28, 2003, under the title Koi Shimai (恋姉妹). The manga was transferred to Comic Yuri Hime, Yuri Shimai's successor, published by Ichijinsha.  The final chapter was published in the eleventh issue of Comic Yuri Hime, and three bound volumes have been released, with the final one on April 18, 2008. The manga has been licensed by Los Angeles–based company Seven Seas Entertainment and the first volume went on sale in January 2008, but the series is now on hold due to rights issues. Three drama CDs based on this series have been released, the first two under the title Koi Shimai and the third under the title Hatsukoi Shimai.

Yuri Shimai
Yuri Shimai (百合姉妹, lit. Lily Sisters) was a yuri manga anthology magazine published quarterly by Japanese publisher Sun Magazine.The magazine existed between June 2003 and November 2004. It was part of what still is a small niche market, with only a few manga magazines in Japan that specializes in the yuri (i.e. lesbian-themed) genre. The magazine also contained one-shots and light novels. The magazine was discontinued in November 2004 with the fifth volume. The magazine's cover illustrations were done by Reine Hibiki, the illustrator of the yuri light novel series Maria-sama ga Miteru.

The magazine was revived as Comic Yuri Hime by Ichijinsha in July 2005, with many of the same manga authors returning.
Arnaud Binard
Arnaud Binard (born 18 January 1971 in Bordeaux) is a French actor and producer mainly known for his roles in many romantic or detective television hit-series broadcast throughout the French-speaking world such as Sous Le Soleil (1998–1999), France 2's Groupe Flag (2002–2004), TF1's Alice Nevers: The judge is a woman (2002–2007), France 2's Empreintes criminelles (2011), Chérif (2015-2017) or France 3's Agathe Koltès (2016–2019). His feature films include Gabriel Axel's Leïla (2001) or the erotic dramas Grande École (2004) based on Jean-Marie Besset's The Best of Schools or Jean-Claude Brisseau's À l'aventure (2009). Within the English-speaking world, Binnard appeared in Hulu's Guidestones, ABC's Modern Family and plays Laurent in Emily in Paris.

TF1
TF1 (French: [te ɛf œ̃] ⓘ; standing for Télévision Française 1) is a French commercial television network owned by TF1 Group, controlled by the Bouygues conglomerate. TF1's average market share of 24% makes it the most popular domestic network.

TF1 is part of the TF1 Group of mass media companies, which also includes the news channel LCI. It previously owned the satellite TV provider TPS, which was sold to Canal+ Group.

The network is a supporter of the Hybrid Broadcast Broadband TV (HBBTV) initiative, promoting and establishing an open European standard for hybrid set-top boxes for the reception of terrestrial TV and broadband multimedia applications with a single user interface.
1987 Okinawan Tu-16 airspace violation
The 1987 Okinawan Tu-16 airspace violation (対ソ連軍領空侵犯機警告射撃事件, Tai Soren-gun ryōkū shinpan-ki keikoku shageki jiken) was an incident on December 9, 1987 in which a Tupolev Tu-16P Badger J1 (an electronic warfare version of the Tu-16 bomber) of the Soviet Air Force repeatedly entered Japanese airspace over Okinawa and Kagoshima prefectures. This prompted a F-4EJ Phantom fighter of the Japan Air Self-Defense Force (JASDF) to fire warning shots on two occasions. It was the first time aircraft of the JASDF had done so in response to an aircraft intruding in Japanese airspace. The Soviet Union apologized, claiming that the intrusion was accidental and due to meteorological conditions.

Soviet Air Forces
The Soviet Air Forces (Russian: Военно-Воздушные Силы Союза Советских Социалистических Республик, romanized: Voenno-Vozdushnye Sily Soyuza Sovetskih Sotsialisticheskih Respublik, lit. 'Military Air Forces of the Union of Soviet Socialist Republics'; abbr. VVS SSSR; sometimes referred to as the "Red Air Force") was one of  two air forces belonging to the Soviet Union. The other was the Soviet Air Defence Forces. The Air Forces were formed from components of the Imperial Russian Air Service in 1917, and faced their greatest test during World War II. The groups were also involved in the Korean War, and dissolved along with the Soviet Union itself in 1991–92. Former Soviet Air Forces' assets were subsequently divided into several air forces of former Soviet republics, including the new Russian Air Force. The "March of the Pilots" was its marching song.
Ingrid Neel
Ingrid Neel (born June 16, 1998) is an American-Estonian professional tennis player. She has specialized in doubles and has won four titles on the WTA Tour and three titles on the WTA Challenger Tour. In addition, she has won two singles and 14 doubles titles on the ITF Circuit. On 6 May 2024, she achieved a career-high of No. 33 in the WTA doubles rankings.

WTA 125 tournaments
WTA 125 tournaments are an international series of professional women's tennis tournaments organized by the Women's Tennis Association since 2012.
Also called the WTA Challengers (analogous to the trademarked men's ATP Challenger Tour), the WTA 125 is the second highest level of women's competition, below the top-tier WTA Tour, and above the ITF Women's World Tennis Tour tournaments.

Players who succeed in the WTA 125 tournaments earn sufficient overall WTA ranking points to become eligible for the main draw or qualifying draw entry of WTA Tour tournaments. Results such as titles won at a WTA 125 event are separately counted from the same player's achievements at WTA Tour level tournaments. However match results from WTA 125 events are counted and added into WTA players' overall head-to-head win/loss statistics.
The George Jones Story
The George Jones Story is a double album by George Jones.  It was released on the Musicor label in 1968.

The album is a mixed bag of new recordings, covers of recent hits, and re-recordings of some early hits by Jones, including the Starday cuts "Seasons of My Heart" and "Color of the Blues".  The album also features "I Threw Away the Rose" and "Swinging Doors", both written and made famous by Merle Haggard, who was becoming one of country music's biggest stars at the time.

George Jones
George Glenn Jones (September 12, 1931 – April 26, 2013) was an American country musician, singer, and songwriter. He achieved international fame for a long list of hit records, and is well known for his distinctive voice and phrasing. For the last two decades of his life, Jones is frequently referred to as "the greatest country singer", "The Rolls-Royce of Country Music", and had more than 160 chart singles to his name from 1955 until his death in 2013.

Jones served in the United States Marine Corps and was discharged in 1953. In 1959, Jones recorded "White Lightning", written by The Big Bopper, which launched his career as a singer. Years of alcoholism severely compromised his health and led to his missing many performances, earning him the nickname "No Show Jones". Jones died in 2013, aged 81, from hypoxic respiratory failure.
Salhia Brakhlia
Salhia Brakhlia (born 13 May 1986; Condé-sur-l'Escaut) is a French political journalist. She has contributed to television programs on Canal +, BFM TV, TMC (for the Quotidien program) and France Info since 2020.

Quotidien
Quotidien (French pronunciation: [kɔtidjɛ̃]), also known online as The French show with the good lighting, is a French television show, first broadcast 12 September 2016 on the channel TMC. It is presented by Yann Barthès.
Nicolet College
Nicolet College is a public community college with its main campus in Rhinelander, Wisconsin. It has outreach centers in Carter, Crandon, Eagle River, the Forest County Potawatomi Community, Lac du Flambeau, Minocqua, Mole Lake, and Tomahawk.

It is one of 16 colleges in the Wisconsin Technical College System. Created in 1967, the Nicolet district covers all of Oneida, Vilas and Forest counties and portions of Lincoln, Langlade and Iron counties.

Lac du Flambeau, Wisconsin
The Town of Lac du Flambeau is located in Vilas County, Wisconsin, United States. The population was 3,004 at the 2000 census. The land base of the Lac du Flambeau Band of Lake Superior Chippewa is located within the town and also consists of a large portion of the town. The Lac du Flambeau census-designated place is located within the town. The unincorporated community of Marlands is also located in the town. Lac du Flambeau, situated around Flambeau Lake, is a year-round vacation destination.
The RZA Presents: Afro Samurai Resurrection OST
The RZA Presents: Afro Samurai Resurrection The Soundtrack is the soundtrack to 2009 anime television film Afro Samurai: Resurrection. It was released on January 27, 2009, via Wu Music Group/Koch Records, serving as a sequel to RZA's 2007 Afro Samurai The Soundtrack. Recording sessions mostly took place at 36 West in North Hollywood. Produced entirely by RZA, the album features contributions from Kool G Rap, Rah Digga, Shavo Odadjian, Sly Stone, and Wu-Tang Clan members and affiliates.

North Hollywood, Los Angeles
North Hollywood (NoHo) is a neighborhood and district in the San Fernando Valley of Los Angeles, California. The neighborhood contains the NoHo Arts District, El Portal Theater, several art galleries, and the Academy of Television Arts & Sciences. The North Hollywood Metro Rail station is the northern terminus of the B Line subway on the Los Angeles Metro.

North Hollywood was established by the Lankershim Ranch Land and Water Company in 1887. It was first named "Toluca" before being renamed "Lankershim" in 1896 and finally "North Hollywood" in 1927.