hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
IONIS-GCCRRx
IONIS-GCCRRx, also known as ISIS-426115, is an antiglucocorticoid which is under development by Ionis Pharmaceuticals for the treatment of diabetes mellitus type 2. It has also been under investigation for the treatment of Cushing's syndrome, but no development has been reported. The drug is an antisense oligonucleotide against the glucocorticoid receptor. As of December 2017, it is in phase II clinical trials for diabetes mellitus type 2.

Antiglucocorticoid
Antiglucocorticoid drugs are a class of medications that act to reduce the effects of glucocorticoids, primarily cortisol, in the body. They include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, ketoconazole, and aminoglutethimide. They are used to treat Cushing's syndrome.

These drugs have also been investigated for their potential therapeutic benefits in various psychiatric disorders, particularly depression and psychosis. The rationale behind using antiglucocorticoids in psychiatry stems from the observed dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in many psychiatric conditions, which often manifests as elevated cortisol levels.
Laflin, Missouri
Laflin is an unincorporated community in the southeastern part of Lorance Township in Bollinger County, Missouri, United States. The community is on the Crooked Creek floodplain at the end of Missouri Route U. Marble Hill is approximately 4.5 miles to the northwest.

Marble Hill, Missouri
Marble Hill is a fourth-class city in central Bollinger County in Southeast Missouri, United States. It is well known for its yearly cooking competition located at the park. Located at the intersection of State Highways 34 and 51, it is the largest city in Bollinger and serves as the county seat. The population was 1,388 at the 2020 census. The city was officially organized in July 1851 and is named after the marble-like rock, limestone, formations found in the area.

Marble Hill is part of the Cape Girardeau−Jackson, MO-IL Metropolitan Statistical Area.
Junk Head
Junk Head (Japanese: ジャンク・ヘッド) is a 2017 Japanese animated post-apocalyptic science fiction film written and directed by Takehide Hori, based on his 2013 short film Junk Head 1. The film comprises some 140,000 stop-motion shots, and runs for 101 minutes. The story is set in a distant future world where humans have received longevity but lost their fertility, and are nearly extinct by population decline.

Director Guillermo del Toro positively reviewed the film and it won three awards. It is the first film in a planned trilogy, with the second film, Junk World, released in June 2025.

Fantasia International Film Festival
The Fantasia International Film Festival, also known as Fantasia Fest or simply Fantasia, is an annual film festival founded in 1996 and held primarily in Montreal, Canada. It specializes in genre films, including fantasy, horror, science fiction, and cult cinema, and draws over 100,000 attendees each year.

Fantasia is frequently cited as the leading genre film festival in North America, and is considered one of the top three genre festivals worldwide, alongside Sitges and Fantastic Fest. Its mission is to promote genre, anti-Hollywood cinema and assist independent filmmakers, having launched the careers of many modern auteurs throughout the years.

Since 2012, the festival has also held the Frontières cinema market that allows promising projects to find potential producers and distributors. Since 2016, Frontières has partnered with the Marché du Film, led by the Cannes Film Festival, and from 2026, with the European Film Market at the Berlin International Film Festival.
Meitei language in Bangladesh
The Meitei language (Meitei: ꯃꯩꯇꯩ ꯂꯣꯟ/মৈতৈ লোন, romanized: Meitei Lon), or Manipuri language (Meitei: ꯃꯅꯤꯄꯨꯔꯤ ꯂꯣꯟ/মণিপুরী লোন, romanized: Manipuri Lon), is a minority language in Bangladesh. It is spoken by around 15,000 ethnic Manipuris, mainly concentrated in the Sylhet Division. The Meitei language is also a second language for Bishnupriyas in Bangladesh.

Due to a shrinking population, many Manipuris in Sylhet do not speak the Meitei language fluently, as they make more use of the majority Bengali language, and may speak with a Bangladeshi accent.

Associations and organizations including the Manipuri Language Research and Development Organisation, Bangladesh, the Bangladesh Manipuri Sahitya Sangsad, and the Manipur Cultural Complex work for the development of the Manipuri language, literature, and culture in Bangladesh.

Habiganj District
Habiganj District (Bengali: হবিগঞ্জ জেলা; Bengali pronunciation: [ɦobigɔnd͡ʒ d͡ʒela]), formerly known as Habibganj District (Bengali: হাবিবগঞ্জ জেলা), is a district in north-eastern Bangladesh, located in the Sylhet Division. It was established as a district in 1984 as a successor to its subdivision status since 1867. It is named after its founder, Syed Habib Ullah, son of Syed Hedayet Ullah, who is the founder of Sultani Habeli.
Kutuleh-ye Aziz Khan
Kutuleh-ye Aziz Khan (Persian: كوتوله عزيزخان, also Romanized as Kūtūleh-ye ‘Azīz Khān; also known as Kūtūleh and Kotūleh) is a village in Gol Gol Rural District, in the Central District of Kuhdasht County, Lorestan Province, Iran. At the 2006 census, its population was 169, in 34 families.

Gol Gol Rural District
Gol Gol Rural District (Persian: دهستان گل گل) is in the Central District of Kuhdasht County, Lorestan province, Iran. Its capital is the village of Eshtareh-ye Gol Gol. The previous capital of the rural district was the village of Sepideh-ye Gol Gol.
Merkit
The Merkit (/ˈmɜːrkɪt/; Mongolian: [ˈmircɪt]; lit. 'Wise Ones') was one of the five major tribal confederations of Mongol or Turkic origin in the 12th-century Mongolian Plateau.

The Merkits lived in the basins of the Selenga and lower Orkhon River (modern south Buryatia, Bulgan Province and Selenge Province). After a struggle of over 20 years, they were defeated in 1200 by Genghis Khan and their lands were incorporated into the Mongol Empire.

Keraites
The Keraites (also Kerait, Kereit, Khereid, Kazakh: керейт; Kyrgyz: керей; Mongolian: ᠬᠡᠷᠢᠶᠡᠳ, Хэрэйд; Nogai: Кереит; Uzbek: Kerait; Chinese: 克烈, Persian: کرایت) were one of the five dominant Turco-Mongol tribal confederations (khanates) in the Altai-Sayan region during the 12th century. They had converted to the Church of the East in the early 11th century and are one of the possible sources of the European Prester John legend.

Their original territory was expansive, corresponding to much of what is now Mongolia. Vasily Bartold (1913) located them along the upper Onon and Kherlen rivers and along the Tuul river. They were defeated by Genghis Khan in 1203 and became influential in the rise of the Mongol Empire, and were gradually absorbed into the succeeding Mongol khanates during the 13th century.
Sofia University (California)
Sofia University is a private for-profit university with two locations in California, one in Costa Mesa and the other in Palo Alto. It was originally founded as the California Institute of Transpersonal Psychology by Robert Frager and James Fadiman in 1975.

For-profit higher education in the United States
For-profit higher education in the United States refers to the commercialization and privatization of American higher education institutions. For-profit colleges have been the most recognizable for-profit institutions, and more recently with online program managers, but commercialization has been part of US higher education for centuries. Privatization of public institutions has been increasing since at least the 1980s.
Lipicze Olendry
Lipicze Olendry [liˈpit͡ʂɛ ɔˈlɛndrɨ] is a village in the administrative district of Gmina Goszczanów, within Sieradz County, Łódź Voivodeship, in central Poland. It lies approximately 6 km (4 mi) north-west of Goszczanów, 33 km (21 mi) north-west of Sieradz, and 69 km (43 mi) west of the regional capital Łódź.

Goszczanów
Goszczanów [ɡɔʂˈt͡ʂanuf] is a village in Sieradz County, Łódź Voivodeship, in central Poland. It is the seat of the gmina (administrative district) called Gmina Goszczanów. It lies approximately 27 km (17 mi) north-west of Sieradz and 67 km (42 mi) west of the regional capital Łódź.

There is a parish church of Saints Martin & Stanislaus. Founded by Adam Poniatowski herbu (Coat of Arms) Szreniawa and built in 1666, in Baroque style.
Elizabeth (elephant seal)
Elizabeth was an elephant seal that lived in the Christchurch, New Zealand, Avon / Ōtākaro and Ōpāwaho / Heathcote rivers beginning in the late 1970s until her death in 1985. She would sunbathe on the riverbanks, often in Dallington, but she also made an appearance at Taylors Mistake. She would occasionally get onto the roads, even getting hit by a car in 1985, but she was not injured. The Ministry of Transport would scare her into going into the Heathcote River using sirens and lights, but the Marine Mammals Protection Act 1978 prevented authorities from "disturbing" her. In 1985 Elizabeth died on Scarborough Beach, to a viral infection, according to an autopsy.

Ōpāwaho / Heathcote River
The Ōpāwaho / Heathcote River is located within the city boundaries of Christchurch, New Zealand. It is primarily fed by springs near Templeton Road, with its catchment area extending westward to Yaldhurst and Pound Road during wet weather. The river meanders around the base of the Port Hills, flowing from west to south-east.
Economy (religion)
In the Eastern Orthodox Church, Catholic Church, and in the teachings of the Church Fathers which undergirds the theology of those communions, economy or oeconomy (Greek: οἰκονομία, oikonomia) has several meanings. The basic meaning of the word is "handling" or "disposition"  or "management"  of a thing, or more literally "housekeeping", usually assuming or implying good or prudent handling (as opposed to poor handling) of the matter at hand. In short, economia is a discretionary deviation from the letter of the law in order to adhere to the spirit of the law and charity. This is in contrast to legalism, or akribia (Greek: ακριβεια), which is strict adherence to the letter of the law of the church.

Legalism (theology)
In Christian theology, "legalism" (or "nomism") is a pejorative term applied by some denominations and sects to the idea that "by doing good works or by obeying the law, a person earns and merits salvation." The term has been criticized by certain Christian traditions, such as Conservative Anabaptists who have said that being a disciple of Jesus means being obedient to New Testament commands (such as the holy kiss, baptism, communion, headcovering, and feet washing), and the same is "crucial evidence that an individual has repented, believed, and yielded to Christ."
Louis Delétraz
Louis Charles Hubert Delétraz (born 22 April 1997) is a Swiss racing driver currently competing in the IMSA SportsCar Championship for Cadillac Wayne Taylor Racing and in the European Le Mans Series for AO by TF.

Delétraz won the Formula Renault Northern European Cup in 2015, as well as being a record-setting four-time champion in the European Le Mans Series. He also won the LMP2 Pro-Am class of the 2025 24 Hours of Le Mans. He is the son of former Formula One and Le Mans 24 Hours class winner Jean-Denis Delétraz.

2024 12 Hours of Sebring
The 2024 12 Hours of Sebring (formally known as the 72nd Mobil 1 Twelve Hours of Sebring Presented by Cadillac) was an endurance sports car race held at Sebring International Raceway near Sebring, Florida, scheduled from March 13 to 16, 2024. It was the second round of both the 2024 IMSA SportsCar Championship and the Michelin Endurance Cup.
Entomologia Carniolica
Entomologia Carniolica exhibens insecta Carnioliae indigena et distributa in ordines, genera, species, varietates is a taxonomic work by Giovanni Antonio Scopoli, published in Vienna in 1763. As well as describing hundreds of new species, Entomologia Carniolica contained observations on the species' biology, including the first published account of queen bees mating outside the hive.

Queen bee
A queen bee is typically an adult, mated female (gyne) that lives in a colony or hive of honey bees. With fully developed reproductive organs, the queen is usually the mother of most, if not all, of the bees in the beehive. Queens are developed from larvae selected by worker bees and specially fed in order to become sexually mature. There is normally only one adult, mated queen in a hive, in which case the bees will usually follow and fiercely protect her.

The term "queen bee" can be more generally applied to any dominant reproductive female in a colony of a eusocial bee species other than honey bees. However, as in the Brazilian stingless bee (Schwarziana quadripunctata), a single nest may have multiple queens or even dwarf queens, ready to replace a dominant queen in case of a sudden death.
History of Siberia
The early history of Siberia was greatly influenced by the sophisticated nomadic civilizations of the Scythians (Pazyryk) on the west of the Ural Mountains and Xiongnu (Noin-Ula) on the east of the Urals, both flourishing before the common era. The steppes of Siberia were occupied by a succession of nomadic peoples, including the Khitan people, various Turkic peoples, and the Mongol Empire. In the Late Middle Ages, Tibetan Buddhism spread into the areas south of Lake Baikal.

During the Russian Empire, Siberia was chiefly developed as an agricultural province. The government also used it as a place of exile, sending Avvakum, Dostoevsky, and the Decemberists, among others, to work camps in the region. During the 19th century, the Trans-Siberian Railway was constructed, supporting industrialization. This was also aided by discovery and exploitation of vast reserves of Siberian mineral resources.

Irtysh
The Irtysh (/ɜːrˈtɪʃ, ˈɪərtɪʃ/) is a river in Russia, China, and Kazakhstan. It is the chief tributary of the Ob and is also the longest tributary in the world.

The river's source lies in the Mongolian Altai in Dzungaria (the northern part of Xinjiang, China) close to the border with Mongolia.

The Irtysh's main tributaries include the Tobol, Demyanka and the Ishim. The Ob-Irtysh system forms a major drainage basin in Asia, encompassing most of Western Siberia and the Altai Mountains.
Korrehi, Marvdasht
Korrehi (Persian: كره اي, also Romanized as Korreh’ī; also known as Korā’ī, Korranī, and Korūnī) is a village in Rahmat Rural District, Seyyedan District, Marvdasht County, Fars province, Iran. At the 2006 census, its population was 1,170, in 291 families.

Rahmat Rural District
Rahmat Rural District (Persian: دهستان رحمت) is in Seyyedan District of Marvdasht County, Fars province, Iran. Its capital is the village of Kareh Tavi. The previous capital of the rural district was the village of Abbasabad.
Marion Babcock Baxter
Marion Babcock Baxter (April 12, 1850 – November 18, 1910) was an American lecturer and author.

At twenty years of age, she delivered her first public address at Jonesville, Michigan. It attracted wide and favorable attention, and fixed her vocation as a lecturer. From that time, she was constantly before the public, speaking to large audiences in all parts of the country, temperance and women's suffrage generally being her theme, but also social and political relations of society.

Baxter served as president of Wayside Mission Hospital, located on the good ship Idaho, a side-wheel steamer built in 1860 for the Columbia River business. It was Seattle, Washington's first hospital ship.

Her writing included a poetry collection, serving as a correspondent for various newspapers, and her work as an editorial writer.

Frances Willard
Frances Elizabeth Caroline Willard (September 28, 1839 – February 17, 1898) was an American educator, temperance reformer, and women's suffragist. Willard became the national president of Woman's Christian Temperance Union (WCTU) in 1879 and remained president until her death in 1898. Her influence continued in the next decades, as the Eighteenth (on Prohibition) and Nineteenth (on women's suffrage) Amendments to the United States Constitution were adopted. Willard developed the slogan "Do Everything" for the WCTU and encouraged members to engage in a broad array of social reforms by lobbying, petitioning, preaching, publishing, and education.

Willard's accomplishments include raising the age of consent in many states and passing labor reforms, most notably including the eight-hour work day. She also advocated for prison reform, scientific temperance instruction, Christian socialism, and the global expansion of women's rights.
Cycas angulata
Cycas angulata is a species of cycad in the genus Cycas, native to Australia in northeast Northern Territory (lower reaches of the Foelsche, Robinson and Wearyan Rivers near Borroloola) and northwest Queensland (Bountiful Islands).

Cycas
Cycas is a genus of cycad, and the only genus in the family Cycadaceae with all other genera of cycad being within the Zamiaceae family. Cycas circinalis, a species endemic to India, was the first cycad species to be described in western literature, and is the type species of the genus.

As of April 2024, there are 119 accepted species within the genus Cycas, all of which are native to Asia, Oceania, and eastern Africa and the Indian ocean region, with the largest number of species native to Australia, China and Vietnam.

In horticulture, the most widely grown and perhaps best-known Cycas species is Cycas revoluta, which is commercially grown in large numbers for sale as houseplants or to be used in landscaping.

The majority of Cycas species are highly endangered. Many are threatened by the illegal trade of wild collected plants for plant collectors, and through the conversion of land for urban development or agricultural use.
1935 college football season
The 1935 college football season was the last one before the Associated Press (AP) writers' poll was used in selecting the national champion. There were seven contemporary math system selectors that year who are informally recognized by the NCAA as "nationwide in scope". The Dickinson System, run by University of Illinois Professor Frank Dickinson, selected Southern Methodist University (SMU) as best in the nation. The Houlgate System, created by Carroll Everard "Deke" Houlgate Sr., also selected SMU. The contemporary Boand, Litkenhous and Poling math rating systems all selected Minnesota as the No. 1 team in the nation. The Dunkel System selected Princeton as its top team. The Williamson System, by Paul O. Williamson of New Orleans, ranked Texas Christian University first.

The 1935 season also marked the first time the Heisman Trophy was awarded. It was won by Jay Berwanger of Chicago.  Quarterback Ray Zeh of Case Western Reserve led the nation in scoring.

Jay Berwanger
John Jacob "Jay" Berwanger (March 19, 1914 – June 26, 2002) was an American college football player and referee. In 1935, Berwanger was the first recipient of the Downtown Athletic Club Trophy, renamed the Heisman Trophy the following year. At its inception, the award was given to "the most valuable player east of the Mississippi."  In 1936, Berwanger became the first player drafted into the National Football League in its inaugural 1936 NFL draft, although he did not play professionally due to a salary dispute.
Arnhold Holdings Ltd.
Arnhold Holdings Ltd (Stock Code: SEHK 0102) is a public company listed on the Hong Kong Stock Exchange and is a leading name in the distribution of building materials and engineering equipment in China. It is the corporate descendant of Arnhold, Karberg & Co., a company founded in 1857, and prominent "amongst the merchants who have contributed largely to the development of China's commerce" in the late nineteenth and early twentieth centuries. Employing more than 650 people, its headquarters has been in Hong Kong since 1949, with sales offices in both Shanghai and Macau.

Hankou
Hankou, alternately romanized as Hankow (simplified Chinese: 汉口; traditional Chinese: 漢口; pinyin: Hànkǒu), was one of the three towns (the other two were Wuchang and Hanyang) merged to become modern-day Wuhan city, the capital of the Hubei province, China. It stands north of the Han and Yangtze Rivers where the Han flows into the Yangtze. Hankou is connected by bridges to its triplet sister towns Hanyang (between Han and Yangtze) and Wuchang (on the southern side of the Yangtze).

Hankou is the main port of Hubei Province and the single largest port in the middle reaches of Yangtze.
Du Jiahao
Du Jiahao (Chinese: 杜家毫; born 31 July 1955) is a Chinese politician, serving since 2016 as the Party Secretary of Hunan. He served between 2013 and 2016 as the Governor of Hunan. Before that, he served as Vice Governor of Heilongjiang province, and also held many positions in Shanghai, including party chief of the Pudong New Area.

Governor of Hunan
The governor of Hunan, officially the Governor of the Hunan Provincial People's Government, is the head Hunan Province and leader of the Hunan Provincial People's Government.

The governor is elected by the Hunan Provincial People's Congress, and responsible to it and its Standing Committee. The governor is a provincial level official and is responsible for the overall decision-making of the provincial government. The governor is assisted by an executive vice governor as well as several vice governors. The governor generally serves as the deputy secretary of the Hunan Provincial Committee of the Chinese Communist Party and as a member of the CCP Central Committee. The governor is the second highest-ranking official in the province after the secretary of the CCP Hunan Committee. The current governor is Mao Weiming, who took office on 27 November 2020.
Tagesschau24
Tagesschau24 ([ˈtaːɡəs.ʃaʊ̯ fiːɐ̯ ʊn ˈt͡sʋansɪç], "Review of the Day 24," stylized as tagesschau24) is a German free-to-air television channel owned by ARD and managed by Norddeutscher Rundfunk. Launched on 30th August 1997 as "EinsExtra", the channel was renamed Tagesschau 24 on 1st  May 2012.

It is ARD's news channel and competes with Welt and n-tv. Besides news, Tagesschau24 also broadcasts culture, sports and science shows. A HD simulcast of the channel was launched on 5 December 2013.

Welt (TV channel)
Welt ([vɛlt] ⓘ, "World") (known as N24 from its launch in 2000 to 2018) is a German free-to-air television news channel owned by WeltN24 GmbH, itself a subsidiary of Axel Springer SE.

On 21 September 2017, WeltN24 announced that N24 would be rebranded as "Welt" on 18 January 2018. WeltN24 also publishes Die Welt, a conservative-leaning newspaper.
Star Trek: 25th Anniversary (computer game)
Star Trek: 25th Anniversary is an adventure video game developed and published by Interplay Productions in 1992, based on the Star Trek universe. The game chronicles various missions of James T. Kirk and his crew of the USS Enterprise. Its 1993 sequel, Star Trek: Judgment Rites, continues and concludes this two-game series.

The game was originally released on floppy disks. It was later rereleased on CD-ROM with expansions as well as enhanced audio including the entire principal cast of the original television series performing the game's dialogue.

Fan game
A fan game is a video game that is created by fans of a certain topic or IP. They are usually based on one, or in some cases several, video game entries or franchises. Many fan games attempt to clone or remake the original game's design, gameplay, and characters, but it is equally common for fans to develop a unique game using another as a template. Though the quality of fan games has always varied, recent advances in computer technology and in available tools, e.g. through open source software, have made creating high-quality games easier. Fan games can be seen as user-generated content, as part of the retrogaming phenomena, and as expression of the remix culture.