hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Replisome
The replisome is a complex molecular machine that carries out replication of DNA.  The replisome first unwinds double stranded DNA into two single strands.  For each of the resulting single strands, a new complementary sequence of DNA is synthesized.  The total result is formation of two new double stranded DNA sequences that are exact copies of the original double stranded DNA sequence.

In terms of structure, the replisome is composed of two replicative polymerase complexes, one of which synthesizes the leading strand, while the other synthesizes the lagging strand. The replisome is composed of a number of proteins including helicase, RFC, PCNA, gyrase/topoisomerase, SSB/RPA, primase, DNA polymerase III, RNAse H, and DNA ligase.

Processivity
In molecular biology and biochemistry, processivity is an enzyme's ability to catalyze "consecutive reactions without releasing its substrate".

For example, processivity is the average number of nucleotides added by a polymerase enzyme, such as DNA polymerase, per association event with the template strand. Because the binding of the polymerase to the template is the rate-limiting step in DNA synthesis, the overall rate of DNA replication during S phase of the cell cycle is dependent on the processivity of the DNA polymerases performing the replication. DNA clamp proteins are integral components of the DNA replication machinery and serve to increase the processivity of their associated polymerases. Some polymerases add over 50,000 nucleotides to a growing DNA strand before dissociating from the template strand, giving a replication rate of up to 1,000 nucleotides per second.
Global Thinkers Forum
Global Thinkers Forum (GTF) is a non-profit, London-based organization and was incubated at Oxford University's Saïd Business School in 2011.  It was created to "help our societies and leaders navigate a very complex world". GTF launched in 2012 in Amman, Jordan.

Marianna Vardinogiannis
Marianna V. Vardinogiannis (Greek: Μαριάννα Βαρδινογιάννη, née Μπουρνάκη Bournaki; 2 June 1937 – 24 July 2023) was a Greek UNESCO Goodwill Ambassador and an advocate for the rights of children and the family, and against child sexual abuse via her Foundation for the Child and the Family. She was the President of the Elpida (English: Hope) Association of friends of children with cancer. She was married to Greek shipping magnate Vardis Vardinogiannis.
2023 U Sports Women's Ice Hockey Championship
The 2023 U Sports Women's Ice Hockey Championship was held March 16–19, 2023, in Montreal, Quebec, to determine a national champion for the 2022–23 U Sports women's ice hockey season. The eighth-seeded Mount Royal Cougars defeated the defending champion Concordia Stingers by a score of 4–3 in overtime to win the program's first national title.

U Sports women's ice hockey championship
The U Sports Women's Ice Hockey Championship, is a Canadian university ice hockey tournament conducted by U Sports, and determines the women's national champion. The tournament involves the champions from each of Canada's four regional sports conferences. The Golden Path Trophy is awarded to the winners.
1995–96 New York Islanders season
The 1995–96 New York Islanders season was the 24th season in the franchise's history. This season saw the Islanders finish in last place with a record of 22–50–10 and miss the playoffs for the second straight year. During the season, team management fired General Manager Don Maloney, whom fans blamed for the team's downfall, and gave Mike Milbury total control of hockey operations as both head coach and general manager.

Mike Milbury
Michael James Milbury (born June 17, 1952) is an American former professional ice hockey player and current sports announcer. He played for twelve seasons in the National Hockey League (NHL), all for the Boston Bruins. He helped the Bruins reach the Stanley Cup Finals in 1977 and 1978. He was inducted into the U.S hockey hall of fame in 2006.

Milbury later served as assistant general manager under Harry Sinden and head coach for Boston, as well as general manager and head coach for the New York Islanders. He served as a television color commentator and analyst for the NHL on NBC from 2007 to 2021.
2013 Louis Vuitton Cup
The 8th Louis Vuitton Cup was held during July and August 2013, in San Francisco, California, United States of America. The three contenders were Artemis Racing (Sweden), Emirates Team New Zealand (New Zealand), and Luna Rossa Challenge (Italy). After a preliminary round robin to determine seeding, Artemis Racing was eliminated in the semi-final round by Luna Rossa Challenge by four races to none. In the final, Emirates Team New Zealand beat Luna Rossa Challenge by seven races to one, and went on to challenge Oracle Team USA for the 2013 America's Cup.

2007 Louis Vuitton Cup
The 2007 Louis Vuitton Cup held in Valencia, Spain, from April 16 to June 6 was the event used to select the challenger for the 2007 America's Cup.  Eleven potential challengers competed in the competition which consisted of two round robins, two semi-finals and a final.  The winner was Emirates Team New Zealand, who challenged the defender Alinghi in June 2007 for the America's Cup.
Gmina Bojszowy
Gmina Bojszowy is a rural gmina (administrative district) in Bieruń-Lędziny County, Silesian Voivodeship, in southern Poland. Its seat is the village of Bojszowy, which lies approximately 8 kilometres (5 mi) south of Bieruń and 22 km (14 mi) south of the regional capital Katowice.

The gmina covers an area of 34.07 square kilometres (13.2 sq mi), and as of 2019 its total population is 7,899.

Bieruń-Lędziny County
Bieruń-Lędziny County (Polish: powiat bieruńsko-lędziński) is a unit of territorial administration and local government (powiat) in Silesian Voivodeship, southern Poland. It came into being on January 1, 1999, as a result of the Polish local government reforms passed in 1998. Its administrative seat and largest town is Bieruń, which lies 15 kilometres (9 mi) south-east of the regional capital Katowice. The county also contains the towns of Lędziny, lying 2 km (1 mi) south-east of Bieruń, and Imielin, 7 km (4 mi) east of Bieruń.

Before 2002 the county had its seat in the city of Tychy (outside the county), and was called Tychy County (powiat tyski).

The county covers an area of 156.68 square kilometres (60.5 sq mi). As of 2019 its total population is 59,715, out of which the population of Bieruń is 19,539, that of Lędziny is 16,776, that of Imielin is 9,175, and the rural population is 14,225.
Contemode
Contemode, stylized in all lowercase, was a Japanese record label founded by Yasutaka Nakata in 2003. The label was based in Shibuya, Tokyo and specialized in a variety of music styles including electropop, Shibuya-kei, lounge, dance, and hardcore house. Yamaha Music Communications, the music subsidiary of Yamaha, was its official parent company, while Pony Canyon (from 2003 to 2006) and Avex Trax (from 2006 to 2013) served as its distributors. In 2013, the label officially ceased operations.

Yamaha Corporation
Yamaha Corporation (ヤマハ株式会社, Yamaha Kabushiki gaisha; /ˈjɑːməhɑː/; Japanese pronunciation: [jamaha]) is a Japanese multinational musical instrument and audio equipment manufacturer.

It is one of the constituents of Nikkei 225 and is the world's largest musical instrument manufacturing company.

The former motorcycle division was established in 1955 as Yamaha Motor Co., Ltd., which started as an affiliated company but has been spun-off as its own independent company.
Proroxan
Proroxan (INN; also known as pyrroxane and pirroksan) is a pharmaceutical drug used as an antihypertensive and in the treatment of Ménière's disease, motion sickness, and allergic dermatitis.

Proroxan is a non-selective alpha-blocker (α-adrenoreceptor antagonist).

Proroxan was developed in the 1970s at the Institute of Toxicology of the USSR Ministry of Health and today is primarily used in Russia.  Though originally developed as an antihypertensive, its use can lead to a decrease in alcohol and drug consumption. Currently proroxan is used almost exclusively in psychiatry, narcology, and neurology.

Alpha blocker
Alpha blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of  pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors).

Historically, alpha-blockers were used as a tool for pharmacologic research to develop a greater understanding of the autonomic nervous system. Using alpha blockers, scientists began characterizing arterial blood pressure and central vasomotor control in the autonomic nervous system. Today, they can be used as clinical treatments for a limited number of diseases.

Alpha blockers can treat a small range of diseases such as hypertension, Raynaud's disease, benign prostatic hyperplasia (BPH) and erectile dysfunction. Generally speaking, these treatments function by binding an α-blocker to α receptors in the arteries and smooth muscle. Ultimately, depending on the type of alpha receptor, this relaxes the smooth muscle or blood vessels, which increases fluid flow in these entities.
2023 Nassau County Legislature election
The 2023 Nassau County Legislature Election was held on November 7, 2023, to elect the 19 legislators in Nassau County, New York, one from each of the county's legislative districts. The elections coincided with other elections to various cities, towns, and villages.

The Republican Party maintained their 12–7 majority from the 2021 election.

2021 Nassau County Legislature election
The 2021 Nassau County Legislature Election was held on November 2, 2021, to elect the 19 legislators in Nassau County, New York, one from each of the county's legislative districts. The elections coincided with the county executive and district attorney elections well as other elections to various cities, towns, and villages.

The Republican Party gained one seat, increasing their majority from 11–8 to 12–7.
Isla San Marcos Airstrip
Isla San Marcos Airstrip (IATA: N/A) is a private-use dirt airstrip located on the South coast of Isla San Marcos, Baja California Sur, Mexico, an island located in the Gulf of California.

It is located 10 miles southeast of Santa Rosalía, Municipality of Mulegé.

The airstrip is handled by "Compañía Occidental Mexicana S.A de C.V.", a mining company that exploits the gypsum deposits that exist on the island.

The airstrip  handles national air traffic for the town of San Marcos, the community where the mining company workers and their families live. The airstrip is private-use only, so permission is needed before landing.

Mulegé Municipality
Mulegé is the northernmost municipality of the Mexican state of Baja California Sur. It is the largest municipality by area in Mexico, with an area of 33,092.20 km2 (12,777 sq mi). In the 2020 Census, it had a population of 64,022 inhabitants. Isla Natividad is part of the municipality.

The municipal seat is located in Santa Rosalía. The El Vizcaíno Biosphere Reserve is located in the municipality, between the Pacific Ocean and the Gulf of California. With a landmass of over 24,930 km2 (9,625 sq mi), it is the largest wildlife refuge in Mexico and borders on the northern edge of the Valle de los Cirios Protected Area of Flora and Fauna.
Glomera
Glomera is a genus of orchids (family Orchidaceae), with more than 130 species. They are native to Laos, Indonesia, the Philippines, New Guinea and Melanesia.

The genera Ischnocentrum Schltr. and Sepalosiphon Schltr. are synonyms of this genus.

Rudolf Schlechter
Friedrich Richard Rudolf Schlechter (16 October 1872 – 16 November 1925) was a German taxonomist, botanist, and author of several works on orchids.

He went on botanical expeditions in Africa, Indonesia, New Guinea, South and Central America and Australia.

His vast herbarium was destroyed during the bombing of Berlin in 1945.
A56 road
The A56 is a road in England which extends between the city of Chester in Cheshire and the village of Broughton in North Yorkshire. The road contains a mixture of single and dual carriageway sections, and traverses environments as diverse as the dense urban sprawl of inner city Manchester and the lightly populated region of rural east Lancashire. The road includes a short section of trunk road between the end of the M66 motorway near Ramsbottom and the M65 motorway west of Burnley.

M60 motorway (Great Britain)
The M60 motorway, Manchester Ring Motorway or Manchester Outer Ring Road is an orbital motorway in North West England. Built over a 40-year period, it passes through all of Greater Manchester's metropolitan boroughs except for Wigan and Bolton. Most of Manchester is encompassed within the motorway, except for the southernmost part of the city (Wythenshawe and Manchester Airport) which is served by the M56.

The M60 is 36.1 miles (58.1 km) long and was renamed the M60 in 1998, with parts of the M62, M66 and all of the M63 being amalgamated into the new route, and the circle completed in 2000. The road forms part of the unsigned Euroroutes E20 and E22 from junctions 12 to 18.

In 2008, the M60 was proposed as a cordon for congestion charging in Greater Manchester, although this was rejected in a referendum relating to the Greater Manchester Transport Innovation Fund.
WEQP
WEQP is a Contemporary Christian formatted broadcast radio station licensed to Rustburg, Virginia, serving Lynchburg and Campbell County, Virginia.  WEQP is owned and operated by Calvary Chapel of Lynchburg.

Campbell County, Virginia
Campbell County is a United States county situated in the south central part of the Commonwealth of Virginia. Located in the Piedmont region of Virginia, Campbell borders the Blue Ridge Mountains. At the 2020 census, the county population was 55,696. The number of residents has grown steadily in every census after 1930, and the total population has more than doubled since that time. The county seat is Rustburg.

Grounded on a tobacco cash crop economy, Campbell County was created in 1782 from part of Bedford County. The county was named in honor of General William Campbell, hero of the American Revolutionary War.

Campbell County is part of the Lynchburg metropolitan area. Lynchburg was initially established in Campbell County in 1786, incorporated as a town in 1805, and separated from Campbell County when Lynchburg became an independent city in 1852. Lynchburg has annexed additional land from Bedford County and Campbell County through the years, most recently in 1976.
1999 Anguillian general election
General elections were held in Anguilla on 4 March 1999. The result was a victory for the ruling coalition of the Anguilla United Party and the Anguilla Democratic Party, each winning 2 seats.  The opposition Anguilla National Alliance won 3 seats.  However, the coalition government lost its majority in May 1999 upon the resignation of Victor Banks, the Finance Minister and leader of the Anguilla Democratic Party.  Due to the collapse of the ruling coalition, fresh elections were held in March 2000.

Anguilla Democratic Party
The Anguilla Democratic Party was a political party in Anguilla. It was led by Camile Connor in 1976. At the 2005 Anguillian general election, the party became part of the Anguilla United Front, which won 39% of the popular vote and four out of seven elected seats.
Triclofos
Triclofos (brand names Triclos, Pedicloryl) is a sedative drug used rarely for treating insomnia.

Triclofos is a prodrug which is metabolised in the liver into the active drug trichloroethanol. The half-life of triclofos is fairly long and it may cause drowsiness the next day. Trichloroethanol may cause liver damage and triclofos should not be used for extended periods.

Triclofos is no longer available in the United States.

Sedative
A sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement. They are central nervous system (CNS) depressants and interact with brain activity, causing its deceleration. Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid (GABA). Most sedatives produce relaxing effects by increasing GABA activity.

This group is related to hypnotics. The term sedative describes drugs that serve to calm or relieve anxiety, whereas the term hypnotic describes drugs whose main purpose is to initiate, sustain, or lengthen sleep. Because these two functions frequently overlap, and because drugs in this class generally produce dose-dependent effects (ranging from anxiolysis to loss of consciousness), they are often referred to collectively as sedative–hypnotic drugs.
Brock Jensen
Brock Jensen (born September 19, 1990) is an American former professional football quarterback. He played college football at North Dakota State. He led the North Dakota State Bison to three consecutive national championships (2011–2013). After completing his college career Jensen spent time with the Miami Dolphins, Omaha Mammoths, and Ottawa Redblacks. While with the Ottawa Redblacks he became a Grey Cup champion as the backup to Henry Burris.

Ottawa Redblacks
The Ottawa Redblacks (officially stylized as REDBLACKS) (French: Rouge et Noir d'Ottawa) are a professional Canadian football team based in Ottawa. The team plays in the East Division of the Canadian Football League (CFL).

Starting play in 2014, the Redblacks are the third CFL team to play in the city of Ottawa. The Ottawa Rough Riders, formed in 1876, were a founding member of the CFL in 1958 and played until 1996. A new Ottawa franchise was formed as the Renegades in 2002 and lasted until the end of the 2005 season. The Redblacks won the 2016 Grey Cup Championship, which ended a 40-year Grey Cup championship drought for the city of Ottawa.
Matthew Stafford (politician)
Matthew Stafford (c. 1852 – 12 June 1950) was an Irish businessman and Fianna Fáil politician. He served four terms in Seanad Éireann, over a period of ten years. He was nominated by the Taoiseach to the 2nd Seanad in 1937, the 3rd Seanad in 1938, 4th Seanad in 1943, and to the 5th Seanad in 1944. He only spoke twice in his time in the Seanad. He took part in the 1867 Fenian Rising, and as a sniper in the 1916 Easter Rising.

3rd Seanad
The 3rd Seanad was in office from 1938 to 1943. An election to Seanad Éireann, the Senate of the Oireachtas (Irish parliament), followed the 1938 general election to the 10th Dáil. The senators served until the close of poll for the 4th Seanad in 1943.
Lilies of the Field (1963 film)
Lilies of the Field is a 1963 American comedy drama film directed and produced by Ralph Nelson. Adapted by James Poe from William Edmund Barrett’s 1962 novel, the film takes its title from the Sermon on the Mount. It stars Sidney Poitier as Homer Smith, an itinerant handyman, who encounters a group of East German nuns in the Arizona desert. Led by the determined Mother Maria Marthe, played by Lilia Skala, the nuns believe Homer has been sent by God to build them a chapel.

Praised by critics, Lilies of the Field earned five Academy Award nominations, including Best Picture and Best Supporting Actress for Skala. Poitier won the Academy Award for Best Actor, becoming the first Black actor to win in a leading role. The film also features an early score by Jerry Goldsmith. In 2020, it was selected for preservation in the United States National Film Registry by the Library of Congress as being "culturally, historically, or aesthetically significant".

National Film Registry
The National Film Registry (NFR) is the United States National Film Preservation Board's (NFPB) collection of films selected for preservation, each for its cultural, historical and aesthetic contributions since the NFPB's inception in 1988.
Gmina Biłgoraj
Gmina Biłgoraj is a rural gmina (administrative district) in Biłgoraj County, Lublin Voivodeship, in eastern Poland. Its seat is the town of Biłgoraj, although the town is not part of the territory of the gmina.

The gmina covers an area of 262.64 square kilometres (101.4 sq mi), and as of 2006 its total population is 12,541.

Biłgoraj County
Biłgoraj County (Polish: powiat biłgorajski) is a unit of territorial administration and local government (powiat) in Lublin Voivodeship, eastern Poland. It was established on January 1, 1999, as a result of the Polish local government reforms passed in 1998. Its administrative seat and largest town is Biłgoraj, which lies 79 kilometres (49 mi) south of the regional capital Lublin.
Tokugawa Iesato
Prince Tokugawa Iesato (徳川 家達; 24 August 1863 – 5 June 1940) was a Japanese aristocrat and politician who was the first head of the Tokugawa clan after the overthrow of the Tokugawa shogunate in 1868. He was President of the House of Peers from 1903 to 1933. When he travelled to other nations representing Japan during his diplomatic journeys, he usually presented his name as Prince Iyesato Tokugawa. As President of the House of Peers, Tokugawa promoted democratic principles and international goodwill. It was only after his death in 1940 that Japanese militants were able to push Japan into joining the Axis Powers in World War II.

National Association of Japan–America Societies
The National Association of Japan–America Societies, Inc. (NAJAS) is a private, non-profit, non-partisan organization located in Washington, D.C. that offers educational, cultural and business programs about Japan and U.S.–Japan relations to the public through its member Japan and Japan–America Societies. NAJAS is the only national non-profit network in the United States dedicated to public education about Japan. NAJAS consists of approximately 40 independent Japan-related organizations located in 32 cities around the country. Its membership includes business, political, and academic, as well as American and Japanese members, and affords a variety of perspectives on U.S.–Japan relations.
Henry C. Spencer
Henry Christian Spencer (June 24, 1915 – May 30, 1999) was an American businessman and executive at the Kerite Company in Seymour, Connecticut. As secretary and vice president, he was involved in discussions about unions at the company, and in its joining with Hubbell Company.

Cedar Rapids, Iowa
Cedar Rapids is a city in Linn County, Iowa, United States, and the county seat. The population was 137,710 at the 2020 census, and was estimated at 137,904 in 2024. making it the second-most populous city in Iowa. The city lies on both banks of the Cedar River, 20 miles (32 km) north of Iowa City and 128 miles (206 km) northeast of Des Moines, the state's capital.

Cedar Rapids is the economic hub of Eastern Iowa, located at the core of the Interstate 380 corridor. The population of the three-county Cedar Rapids metropolitan area, which includes the nearby cities of Marion and Hiawatha, was 276,520 in 2020. The Cedar Rapids metropolitan area is also part of a combined statistical area with the Iowa City metropolitan area.