hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
E-52862
E-52862, also known as sigma-1 receptor antagonist (S1A, S1RA), as well as MR-309, is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki = 17.0 ± 7.0 nM, selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels. In preclinical studies, S1RA has demonstrated efficacy in relieving neuropathic pain and pain in other sensitizing conditions, associated with an improvement of the emotional negative state.

S1RA is being developed by Esteve for the treatment of neuropathic pain and the potentiation of opioid analgesia and has successfully completed Phase I clinical trials showing good safety and tolerability, and a pharmacokinetic profile compatible with once a day oral administration. Phase II clinical trials are currently underway, making S1RA the first selective sigma-1 receptor antagonist evaluated in humans for these conditions.

Neuropathic pain
Neuropathic pain is pain caused by a lesion or disease of the somatosensory nervous system. Neuropathic pain may be associated with abnormal sensations called dysesthesia or pain from normally non-painful stimuli (allodynia). It may have continuous and/or episodic (paroxysmal) components. The latter resemble stabbings or electric shocks. Common qualities include burning or coldness, "pins and needles" sensations, numbness and itching.

Up to 7–8% of the European population is affected by neuropathic pain, and in 5% of persons it may be severe. The pain may result from disorders of the peripheral nervous system or the central nervous system (brain and spinal cord). Neuropathic pain may occur in isolation or in combination with other forms of pain. Medical treatments focus on identifying the underlying cause and relieving pain. In cases of peripheral neuropathy, the pain may progress to insensitivity.
2022 Hamilton, New Zealand, mayoral election
The 2022 Hamilton mayoral election was a local election held from 16 September to 8 October in Hamilton, New Zealand, as part of that year's city council election and nation-wide local elections. Voters elected the mayor of Hamilton for the 2022–2025 term of the Hamilton City Council. Postal voting and the single transferable vote and postal voting was used (the latter for the first time).

Incumbent mayor Paula Southgate was re-elected.

2022 New Zealand local elections
The 2022 New Zealand local elections (Māori: Nga Pōtitanga ā-Rohe 2022) were triennial elections that was held from 16 September until 8 October to elect local mayors and councillors, regional councillors, and members of various other local government bodies.

All 11 of New Zealand's regions and 66 of New Zealand's 67 cities and districts participated in the elections; Tauranga City Council was under crown commission and did not hold elections.
Mono City, California
Mono City is an unincorporated community and census-designated place (CDP) in Mono County, California, United States. It lies north of Mono Lake at the base of the Sierra Nevada at the junction of U.S. Route 395 and California State Route 167. The ZIP Code is 93541; mail to Mono City should be addressed Lee Vining. The population was 224 at the 2020 census, up from 172 at the 2010 census.

Lee Vining, California
Lee Vining (formerly Leevining, Poverty Flat, and Lakeview) is an unincorporated community and census-designated place (CDP) in Mono County, California, United States. It is located 25 miles (40 km) south-southeast of Bridgeport. Lee Vining is located on the southwest shore of Mono Lake. The population was 217 as of the 2020 census.
Pikuniku
Pikuniku is an adventure video game developed by French-British indie collective Sectordub and published by Devolver Digital. It was released on January 24, 2019 for Linux, macOS, Nintendo Switch and Microsoft Windows, and was later released on March 12, 2020 for Xbox One and on February 9, 2021 for Stadia. The game won numerous accolades from 2018 to 2020 including the 2020 Best International Indie Game award at the Pégases Awards.

The player controls the titular red creature, Piku, through a colorful world to put an end to a plot to harvest the entirety of the land's resources and save the creatures of the island.

It received generally positive reviews from critics, with its main criticism being the short length of the game.

Pégases
The Pégases awards honor achievements in the French video game industry since 2020. The awards ceremony, Palmarès des Pégase, is held annually.

Since 2022, the ceremony is typically held in the first or second week of March at La Cigale in Paris. The first ceremony, in 2020, was held at Théâtre de la Madeleine, while the second ceremony, in 2021, was held virtually due to the COVID-19 pandemic.
Nadine Coyle
Nadine Elizabeth Louise Coyle (born 15 June 1985) is an Irish singer. In 2002, she was selected as a member of Girls Aloud, a pop girl group created through ITV's reality competition show Popstars: The Rivals. The group went on to receive large success, achieving a string of 20 consecutive UK top ten singles (including four number ones), two UK number one albums, five consecutive platinum selling studio albums, and receiving nominations for five BRIT Awards, winning Best Single in 2009 for "The Promise".

In 2010, Coyle released her debut solo studio album, Insatiable, and its title track, through her own record label, Black Pen Records, in partnership with supermarket giant Tesco. In 2017, she released the single "Go to Work" on Virgin EMI Records, and later that year, she released her debut extended play (EP), Nadine.

Virgin EMI Records
Virgin EMI Records was a British record label owned by the Universal Music Group that was formed in 2013. In June 2020, the label was rebranded as EMI Records, and operates Virgin Records as an imprint of the new EMI Records.
Alejandro Rozas Lopetegui
Alejandro Rozas Lopetegui was a Chilean politician and senator. A member of the Democratic Party, he served as Senator for the 9th Provincial Grouping (Valdivia and Chiloé) during the 1933–1937 legislative period.

Democratic Party (Chile)
The Democratic Party (Partido Democrático) of Chile was a Chilean political party created by a left-wing faction of the Democrat Party in 1932. It was created by a leftist faction of the Democrat Party, which opposed the right-wing group that officially supported the government of Arturo Alessandri.

Although they supported the presidential candidacy of Alessandri, eventually became opponents. In 1937, they joined the Popular Front and supported the candidacy of Pedro Aguirre Cerda. In 1941, they merged with the Democrat Party.

In the 1940s again were divided in the Democratic Party of Chile and the People's Democratic Party. Both parties were reunited in 1956. The party was dissolved in 1960, when meeting with other organizations to form the National Democratic Party (PADENA).
Godthåbhallen
Godthåbhallen is a handball stadium in Nuuk, Greenland. It is the home of the Greenland men's national handball team. The stadium has a capacity of 1,000 people.

The stadium was built in 1961, and is a multi-purpose venue, housing events ranging from concerts to bingo to zumba and bodytoning. The stadium used to be the venue of choice for bigger artists, but since the 2002 completion of the indoor Inussivik sports centre, near Nuuk Stadium, all major artists use this newer, spacier venue. Godthåbhallen is located 400 meters from Nuuk Stadium. An ice skating arena which is open to the public is right outside the hall.

Godthåbhallen hosted the futsal tournament at the 2016 Arctic Winter Games.

Inussivik
Inussivik is an indoor arena located in Nuuk, the capital city of Greenland, that was originally constructed for the 2002 Arctic Winter Games. The arena is used for sports, especially team handball which is considered the national sport of Greenland, concerts, and cultural events.

Inussivik has a capacity of around 1,000 people and is located on a complex with Nuuk Stadium, the country's national stadium.

The arena played host to the 2018 Pan American Men's Handball Championship and 2023 Nor.Ca. Women's Handball Championship.
Jay Daniel
Jay Daniel is an electronic musician, producer, and selector from Detroit, Michigan, United States. In addition to his own label, Watusi High, Daniel has released music on Sound Signature, Wild Oats, and most recently released his debut album, 'Broken Knowz' on Ninja Tune.
Son to Naomi Daniel

Ninja Tune
Ninja Tune is an independent record label based in London, with a satellite office in Los Angeles. It was founded in 1990 by musicians Matt Black and Jonathan More, known collectively as Coldcut. The label was established as an outlet for Coldcut to explore a style distinct from that of the mainstream music industry.
Savica (waterfall)
Savica Falls is a waterfall in northwestern Slovenia. It is 78 meters (256 ft) high and is fed by a karst spring also called Savica just above the waterfall.

A large portion of water is sourced from a karst basin around Black Lake, which lies around 500 meters (1,600 ft) higher above the waterfall, because of which the spring has a relatively steady and strong flow. Water flows to the spring below the ground, where it splits into two parts. After heavy rains, the water supply from the lake and its surroundings may exceed the capacity of tunnels, and a portion of water flows on the surface in cascading waterfalls 600 meters (2,000 ft) high.

The waterfall continues in a stream of the same name, which flows into Lake Bohinj as its main source.  Water from Lake Bohinj is further a source of the Sava Bohinjka, which forms the Sava River after joining with the Sava Dolinka.

Lake Bohinj
Lake Bohinj (Slovene: Bohinjsko jezero), covering 318 hectares (790 acres), is the largest permanent lake in Slovenia. It is located within the Bohinj Valley of the Julian Alps, in the northwestern Upper Carniola region, and part of Triglav National Park.
More Cowbell
"More Cowbell" is a comedy sketch that aired on Saturday Night Live on April 8, 2000. 
The sketch was written by regular cast member Will Ferrell and depicts the recording of the song "(Don't Fear) The Reaper" by Blue Öyster Cult.
The sketch stars guest host Christopher Walken as fictional music producer Bruce Dickinson, and Ferrell as fictional cowbell player Gene Frenkle, whose overzealous playing annoys his bandmates but pleases Dickinson. The sketch also features Chris Parnell as Eric Bloom, Jimmy Fallon as Bobby Rondinelli, Chris Kattan as Buck Dharma, and Horatio Sanz as Joe Bouchard.

The sketch is one of the most popular SNL sketches ever made; in many "best of" lists of SNL sketches, it places in the top ten (ranked number nine by Rolling Stone, for example). As a result of its popularity, "more cowbell" became an American pop culture catchphrase, and it has even entered the dictionary.

(Don't Fear) The Reaper
"(Don't Fear) The Reaper" is a song by the American rock band Blue Öyster Cult from the 1976 album Agents of Fortune. Written and sung by the lead guitarist, Donald "Buck Dharma" Roeser, it deals with eternal love and the inevitability of death. Dharma wrote it while picturing an early death for himself.

Released as an edited single (omitting the slow building interlude in the original), the song is Blue Öyster Cult's highest chart success, reaching #7 in Cash Box and #12 on the Billboard Hot 100 in late 1976. Critical reception was positive and in December 2003 "(Don't Fear) The Reaper" was listed at number 405 on Rolling Stone's list of the top 500 songs of all time.
Ninian Cockburn
Ninian Cockburn (died 6 May 1579) was a Scottish soldier and officer of the Garde Écossaise, a company which guarded the French king. He had an ambiguous role in political relations between Scotland, France and England during the war of the Rough Wooing and the Scottish Reformation.

James Hepburn, 4th Earl of Bothwell
James Hepburn, 1st Duke of Orkney and 4th Earl of Bothwell (c. 1534 – 14 April 1578), better known simply as Lord Bothwell, was the third husband of Mary, Queen of Scots. He was accused of the murder of Mary's second husband, Henry Stuart, Lord Darnley, a charge of which he was acquitted. His marriage to Mary was controversial and divided the country; when he fled the growing rebellion to Norway, he was arrested and lived the rest of his life imprisoned in Denmark.
Remake Our Life!
Remake Our Life! (Japanese: ぼくたちのリメイク, Hepburn: Bokutachi no Rimeiku) or Bokurema is a Japanese light novel series written by Nachi Kio and illustrated by Eretto. Media Factory have published twelve volumes and three spin-off volumes since March 2017 under their MF Bunko J imprint. A manga adaptation with art by Bonjin Hirameki was serialized via Kodansha's Niconico-based Suiyōbi no Sirius manga service from November 2018 to September 2019, before transferring to Magazine Pocket and being serialized from September 2019 to April 2022. It has been collected in seven tankōbon volumes. An anime television series adaptation by Feel aired from July to September 2021.

Niconico
Niconico, Inc. (Japanese: ニコニコ, Hepburn: Nikoniko), known before 2012 as Nico Nico Douga (ニコニコ動画, Niko Niko Dōga), is a Japanese video sharing service based in Tokyo, Japan. "Niconico" or "nikoniko" is the Japanese ideophone for smiling. As of 2021, Niconico is the 34th most-visited website in Japan, according to Alexa Internet.

The site won the Japanese Good Design Award in 2007, and an Honorary Mention of the Digital Communities category at Prix Ars Electronica 2008. Between June 8, 2024 and August 5, 2024, its servers were affected by a cyberattack and the website was partially active.
Vladyslav (given name)
Vladyslav (Ukrainian: Владисла́в [u̯lɐdɪˈslɑu̯] ⓘ) or Volodyslav (Ukrainian: Володисла́в [wolodɪˈslɑu̯]) is a Ukrainian given name for males. The female variant is the same with the addition of 'a' at the end.

The name is of old Slavic origin and is mainly used in Poland. The name derives from the slavic words (Володіти (volodity) - to possess, + слава (slava) - glory, or слово (slovo) - word) meaning one who is a "possessor of glory, fame".

Many of Poland's kings bore this name. Its variant in Russian is Vladislav; Belarusian - Ŭladzislaŭ (Ўладзіслаў); Czech - Ladislav.

In Ukraine and Russia this name became popular in the 1960s and 1970s as Polish culture became popular, as a way to be connected to Western culture that was permitted by the Soviet regime for the Soviet people.

Vladislav
Vladislav (Belarusian: Уладзіслаў (Uladzislaŭ, Uładzisłaŭ); Polish: Władysław, Włodzisław;  Russian, Ukrainian, Bulgarian, Macedonian, Serbo-Croatian Cyrillic: Владислав, Latin: Ladislaus) is a male given name of Slavic origin. Variations include Volodislav, Vlastislav and Vlaslav. In the Czech Republic, Slovakia and Croatia, the common variation is Ladislav.

Outside of Slavic and Eastern Romance countries, it is sometimes latinized as either Vladislaus or Vladislas. Spanish forms include Ladislao and Uladislao. The Portuguese form is Ladislau and the Romanian forms are Vladislav and Ladislau. The Hungarian form is László.

In Russian-speaking countries, it is usually colloquially shortened to either Vlad (Влад) or Vladik (Владик).

The feminine form of the name Vladislav is Vladislava or, in Polish spelling, Władysława.
Amie Beth Dickinson
Amie Beth Dickinson Shaver is an American conservative political activist and beauty pageant titleholder from Shelby County, Alabama, who was named Miss Alabama 1994. She succeeded to the title after Heather Whitestone, the original titleholder, was named Miss America 1995.

Shelby County, Alabama
Shelby County is a county located in the central portion of the U.S. state of Alabama. As of the 2020 census the population was 223,024, making it the sixth-most populous county in Alabama. The county seat is Columbiana. Its largest city is Alabaster. The county is named in honor of Isaac Shelby, Governor of Kentucky from 1792 to 1796 and again from 1812 to 1816. Shelby County is included in the Birmingham, AL Metropolitan Statistical Area.
Harry Carney
Harry Howell Carney (April 1, 1910 – October 8, 1974) was a jazz saxophonist and clarinettist who spent over four decades as a member of the Duke Ellington Orchestra. He played a variety of instruments, but primarily used the  baritone saxophone, being a critical influence on the instrument in jazz.

Benny Goodman
Benjamin David Goodman (May 30, 1909 – June 13, 1986) was an American jazz clarinetist and bandleader, known as the "King of Swing". His orchestra did well commercially.

From 1935 until the mid-1940s, Goodman led one of the most popular swing big bands in the United States. His concert at Carnegie Hall in New York City on January 16, 1938, is described by critic Bruce Eder as "the single most important jazz or popular music concert in history: jazz's 'coming out' party to the world of 'respectable' music."

Goodman's bands started the careers of many jazz musicians. During an era of racial segregation, he led one of the first integrated jazz groups, his trio and quartet. He continued performing until the end of his life while pursuing an interest in classical music.
The Ridin' Rascal
The Ridin' Rascal is a 1926 American silent Western film directed by Clifford Smith based upon the novel Mavericks by William MacLeod Raine. The film stars Art Acord, Olive Hasbrouck, and Buck Connors.

Art Acord
Arthemus Ward "Art" Acord (April 17, 1890 – January 4, 1931) was an American silent film actor and rodeo champion. After his film career ended in 1929, Acord worked in rodeo road shows and as a miner in Mexico.
Franck Prazan
Franck Prazan (born 1966) is a French art collector and the owner of Applicat-Prazan gallery in Paris. He specialises in School of Paris, a Post-War abstract painting movement, whose main artists include Jean-Michel Atlan, Pierre Soulages, Serge Poliakoff, Nicolas de Staël.

The Applicat-Prazan gallery regularly attends international modern art fairs, such as artgenève, Tefaf Maastricht, Art Basel Hong Kong, Tefaf New York Spring, Art Basel Basel, Frieze Masters, Foire Internationale d'Art Contemporain, Art Basel Miami Beach.

Art Basel
Art Basel is a for-profit, privately owned and managed, international series of art fairs whose annual flagship event has long been considered the largest and most prestigious fair of the contemporary and modern art market.  
Art Basel  started in Basel, Switzerland, in 1970. Since then, it has added annual satellite fairs in Miami Beach in the United States, Hong Kong, and Paris. Starting in February 2026, it will also host its first Art Basel event in Doha, Qatar.

The annual fairs bring together galleries, collectors, curators and artists for exhibitions, sales and programming. They also serve as an anchor for numerous other art fairs that simultaneously operate in parallel in the host cities.

Art Basel's parent company is MCH Group a Switzerland-based marketing company. Over recent years, the organization has adopted a strategy of moving  Art Basel from being a series of industry fairs to being a lifestyle brand.
Lautenthalite
Lautenthalite is a mineral that was named after its location, Lautenthal, Harz mountains, Germany. It can be found in several slag localities. It was approved by the IMA in 1993. It is a member of the devilline group, and it is the lead analogue of devilline and campigliaite. Without analytical methods, it is hard to distinguish the mineral from both. It shows pleochroic properties, which is an optical phenomenon. Depending on which angle the mineral is inspected, the color of it differs. On the x optical axis, the mineral could be seen in a pale blue color; on the y and z axis, the mineral's color changes to blue. It has tabular crystals and sheaflike or irregular aggregates. Lautenthalite is associated with wroewolfeite, which it tends to overgrow. It is also associated with anglesite, devilline–serpierite, galena, linarite, brochantite and schulenbergite. It forms small singular crystals with a size of up to 0.5 × 0.3 × 0.03 mm.

Linarite
Linarite is a somewhat rare, crystalline mineral that is known among mineral collectors for its unusually intense, pure blue color. It is formed by the oxidation of galena and chalcopyrite and other copper sulfides. It is a combined copper lead sulfate hydroxide with formula  PbCuSO4(OH)2. 
Linarite occurs as monoclinic prismatic to tabular crystals and irregular masses. It is easily confused with azurite, but does not react with dilute hydrochloric acid as azurite does. It has a Mohs hardness of 2.5 and a specific gravity of 5.3 – 5.5.

Linarite was first identified in 1822. It is named after the Linares Plateau, Spain. It occurs in association with brochantite, anglesite, caledonite, leadhillite, cerussite, malachite and hemimorphite.
Erik Pérez
Erik Gregorio Pérez Ruvalcaba (born November 19, 1989) is a Mexican mixed martial artist who competes in the Bantamweight division. A professional competitor since 2008, he has competed for Bellator MMA, Shark Fights, BAMMA, UFC and Combate Americas.

Bellator MMA
Bellator MMA (formerly Bellator Fighting Championships) was an American mixed martial arts promotion founded in 2008 by Bjorn Rebney and operated until 2025. The promotion takes its name from bellātor, the Latin word for "warrior". Bellator's first event was in 2009, and the promotion held 313 "numbered" events.

Bellator was considered the second largest MMA promotion in the United States, and one of the largest combat sport promotions in the world. Paramount Global (formerly Viacom) purchased majority ownership of Bellator from Rebney in 2011, with Paramount's television networks serving as the promotion's media broadcasters in the United States. On November 20, 2023, after then-broadcast home Showtime announced the discontinuation of its sports division, Bellator MMA was acquired by the Professional Fighters League (PFL).
Udayamperoor Old Church
Gervasis and Prothasis Church, popularly called the Udayamperoor Old Church  or the Udayamperoor Synodal Church, is a Syro-Malabar church located in Udayamperoor, Kerala, India. This is one of the prominent church buildings of Saint Thomas Christians and was the venue of the Udayamperoor Synod, held under Alexis Menezes in 1599. It is a parish church under the Ernakulam-Angamaly Archeparchy of the Syro-Malabar Church. Adjacent to the old church, there is a museum, and a newer church building also operates within the church premises.

Aleixo de Menezes
Archbishop Aleixo de Menezes or Alexeu de Jesu de Meneses (25 January 1559 – 3 May 1617) was a Catholic prelate that served as Archbishop of Goa, Archbishop of Braga and Viceroy of Portugal during the Philippine Dynasty.