hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Prototype drug
In pharmacology and pharmaceutics, a prototype drug is an individual drug that represents a drug class – group of medications having similar chemical structures, mechanism of action and mode of action. Prototypes are the most important, and typically the first developed drugs within the class, and are used as a reference to which all other drugs are compared.

Mode of action
In pharmacology and biochemistry, mode of action (MoA) describes a functional or anatomical change, resulting from the exposure of a living organism to a substance. In comparison, a mechanism of action (MOA) describes such changes at the molecular level.

A mode of action is important in classifying chemicals, as it represents an intermediate level of complexity in between molecular mechanisms and physiological outcomes, especially when the exact molecular target has not yet been elucidated or is subject to debate. A mechanism of action of a chemical could be "binding to DNA" while its broader mode of action would be "transcriptional regulation". However, there is no clear consensus and the term mode of action is also often used, especially in the study of pesticides, to describe molecular mechanisms such as action on specific nuclear receptors or enzymes. Despite this, there are classification attempts, such as the HRAC's classification to manage pesticide resistance.
Laura Waters
Laura Jane Waters FRCP is a British physician, genitourinary consultant at the National Health Service (NHS) Mortimer Market Centre in London. She was chair of the British HIV Association (BHIVA) until 2023 and advises the NHS on HIV treatment. Waters is a regular contributor to Boyz magazine, and throughout the COVID-19 pandemic provided regular advice to HIV-positive people.

Boyz (magazine)
Boyz was a free, London-based magazine targeted at gay men and the LGBTQ communities. It was distributed mainly through gay bars, pubs, clubs shops and saunas in the United Kingdom. In July 2019 Boyz moved from a weekly to a monthly frequency of publication with its August edition, its first monthly issue. Boyz focused on news, features and photospreads about the gay scene. Boyz website has now been replaced by DirtyBoyz.
Jane Fearon
Jane Fearon (née Hall, 1654 or 1656–1737) was an English Quaker pamphleteer born in Great Broughton, Cumberland. Having had "a godly education", she became a Quaker minister in about 1688. She preached on the Isle of Man, incurring a prison sentence for doing so, and in various parts of Britain.

Cumberland
Cumberland (/ˈkʌmbərlənd/ KUM-bər-lənd) is an area of North West England which was historically a county. The county was bordered by Northumberland to the north-east, County Durham to the east, Westmorland to the south-east, Lancashire to the south, and the Scottish counties of Dumfriesshire and Roxburghshire to the north. The county included the city of Carlisle, part of the Lake District and North Pennines, and the Solway Firth coastline.

Cumberland had an administrative function from the 12th century until 1974, when it was subsumed into Cumbria with Westmorland as well as parts of Yorkshire and Lancashire. It gives its name to the unitary authority area of Cumberland, which has similar boundaries but excludes Penrith.
Nouha Diakité
Nouha Diakité (born 20 December 1980) is a French and Malian basketball player. He is a member of the Mali national basketball team.

In his most recent professional season, 2008–09, Diakate bounced from BK Prostejov of the Czech League to Hyeres-Toulon Var Basket of the French League before landing with CB Illescas Urban CLM in Spain for the last 14 games of the season.  On 31 August 2009, he signed with Pau-Orthez of the Ligue Nationale de Basketball.

Nouha Diakité has played for the Mali national basketball team in the FIBA Africa Championship in 2005, 2007, and 2009.  The team reached the quarterfinals in each of these appearances.

Mali men's national basketball team
Mali national basketball team (French: équipe du Mali de basket-ball) represents Mali in men's international basketball competitions has yet to appear in the FIBA World Championship. Their best performance was during FIBA AfroBasket 2025, where they won a silver medal, only losing to hosts Angola in the final. In 1972, Mali finished with a bronze medal.
Mark Paston
Mark Nelson Paston (born 13 December 1976) is a New Zealand former professional football goalkeeper. He played for the Wellington Phoenix in the A-League from 2007 to 2013 before he retired from professional football. Paston represented New Zealand at Under-23 level and made his full All Whites debut against Indonesia in 1997, but did not feature in another full international until 2003.

Paston was named in the New Zealand 2009 Confederations Cup squad to travel to South Africa, In 2009, he played in the World Cup Qualification playoff against Bahrain, saving a penalty and helping to secure New Zealand's qualification for the World Cup for only the second time in its history and he went all to play goalkeeper for the team in all of New Zealand's matches, including against Slovakia, Italy, and Paraguay.

2009 FIFA Confederations Cup
The 2009 FIFA Confederations Cup was the eighth Confederations Cup, and was held in South Africa from 14 June to 28 June 2009, as a prelude to the 2010 FIFA World Cup. The draw was held on 22 November 2008 at the Sandton Convention Centre in Johannesburg. The opening match and the final was played at Ellis Park Stadium in Johannesburg. The tournament was won by Brazil, who retained the trophy they won in 2005 by defeating the United States 3–2 in the final.
Mayor of High Wycombe
The High Wycombe Mayoralty is unique in that the mayor and officers are traditionally weighed every year.

The Mayor of High Wycombe, a town in Buckinghamshire, England, is chosen each year at the annual meeting of the charter trustees. The charter trustees of the town of High Wycombe are councillors elected for town wards, who have a ceremonial role as charter trustees in addition to their district council responsibilities.

Annually, one of the charter trustees is nominated by their peers to be mayor of the town.

The office of mayor is apolitical and the person represents the town at many civic and ceremonial events, both in the town and at other functions outside the town/district.

Ceremony
A ceremony (UK: /ˈsɛrəməni/, US: /ˈsɛrəˌmoʊni/) is a unified ritualistic event with a purpose, usually consisting of a number of artistic components, performed on a special occasion.

The word may be of Etruscan origin, via the Latin caerimonia.
969th Field Artillery Battalion (United States)
The 969th Field Artillery Battalion was an African American United States Army field artillery unit that saw combat during World War II. The battalion landed at Utah Beach during Operation Neptune, and participated in the liberation of France and Belgium. Along with survivors of the 333rd Artillery Battalion, it gave fire support to the 101st Airborne Division during the siege of Bastogne. (Battle of the Bulge) Because of the heavy losses suffered by the 333rd, some of its remaining members were reassigned to the 969th Field Artillery Battalion after the Battle of the Bulge.

The 969th was equipped with the M1 155 mm howitzer, the primary medium field howitzer in use by U.S. forces during World War II. The gun crews of the 969th were known for singing in cadence as they loaded and fired their guns, and were praised by many veterans who fought in and around Bastogne, including Donald R. Burgett, for their deadly accuracy and precision.

Bastogne
Bastogne (French pronunciation: [bastɔɲ] ⓘ; Dutch: Bastenaken [ˈbɑstəˌnaːkə(n)] ⓘ; German: Bastnach/Bastenach [ˈbast(ə)nax]; Luxembourgish: Baaschtnech [ˈbaːʃtnəɕ] ⓘ) is a city and municipality of Wallonia located in the province of Luxembourg in the Ardennes, Belgium.

The municipality consists of the following districts: Bastogne, Longvilly, Noville, Villers-la-Bonne-Eau, and Wardin. The town is situated on a ridge in the Ardennes at an elevation of 510 metres (1,670 ft).

On 2 December 2024, it merged with Bertogne into a new municipality.
John Stuart Yeates
John Stuart Yeates MBE (11 July 1900 – 24 August 1986) was a New Zealand academic and botanist. The founding head of Agricultural Botany at Massey Agricultural College, he was also an accomplished breeder of azaleas, rhododendrons and lilies.

Azalea
Azaleas (/əˈzeɪliə/ ə-ZAY-lee-ə) are flowering  shrubs in the genus Rhododendron, particularly the former subgenera Tsutsusi (evergreen) and Pentanthera (deciduous). Azaleas bloom in the spring (April and May in the temperate Northern Hemisphere, and October and November in the Southern Hemisphere), their flowers often lasting several weeks. Shade tolerant, they prefer living near or under trees. They are part of the family Ericaceae.
1791 United States Senate election in New York
The 1791 United States Senate election in New York was held on January 19, 1791, by the New York State Legislature to elect a U.S. Senator (Class 1) to represent the State of New York in the United States Senate. The election was conducted by a system of approval voting.

Incumbent Senator Philip Schuyler was not re-elected. Aaron Burr, Attorney General of New York, won majority support in both the State Senate and State Assembly to succeed him.

Attorney General of New York
The attorney general of New York is the chief legal officer of the U.S. state of New York and head of the Department of Law of the state government. The office has existed in various forms since 1626, originally established under the Dutch colonial government of New Netherland.

Democrat Letitia James currently serves as attorney general, in office since January 1, 2019.
On Growing Older
"On Growing Older" is a song by English band Strawbs written by Dave Cousins. The track first appeared on the Grave New World album, although it was written and recorded a few years earlier. The original recording was later released on the Strawberry Sampler Number 1 album.

Dave Cousins
David Joseph Cousins (born David Joseph Hindson; 7 January 1940 – 13 July 2025) was an English musician. He was the leader, singer and most-active songwriter of Strawbs, from 1967.

Cousins was a founding member of Strawbs, which started out as the Strawberry Hill Boys playing bluegrass music, then moved on to folk, folk rock, and progressive rock. He also performed as an acoustic duo with Strawbs guitarist Brian Willoughby, and as Acoustic Strawbs with Willoughby (until August 2004), Dave Lambert and Chas Cronk (from September 2004).
Clan Brodie
Clan Brodie is a Scottish clan whose origins are uncertain. The first known Brodie chiefs were the Thanes of Brodie and Dyke in Morayshire. The Brodies were present in several clan conflicts and, during the civil war, were ardent covenanters. They had indirect involvement in the Jacobite uprising of 1715 but none with that of 1745. Some members of the family worked for the British East India Company in the 18th Century.

County of Moray
The County of Moray, (Scottish Gaelic: Moireibh [ˈmɤɾʲəv]) or Morayshire, called Elginshire until 1919, is a historic county in Scotland. The county town was Elgin. The historic county ceased to be used for local government purposes in 1975. Since 1996 most of the historic county's area has been included in the Moray council area. The historic county boundaries are still used for certain functions, being a registration county. There is also a Moray lieutenancy area, covering a slightly smaller area than the historic county. The historic county borders Nairnshire to the west, Inverness-shire to the south, and Banffshire to the east, and has a coast onto the Moray Firth to the north.
Rip Van Winkle (operetta)
Rip Van Winkle is an operetta in three acts by Robert Planquette. The English language libretto by Henri Meilhac, Philippe Gille and Henry Brougham Farnie was based on the short stories "The Legend of Sleepy Hollow" (1820) and "Rip Van Winkle" (1819) by Washington Irving after the play by Dion Boucicault and Joseph Jefferson.

It first played at the Comedy Theatre in London in 1882 and ran for 328 performances, starring Fred Leslie in the title role. It then toured and was revived in Britain. It also played in New York, Vienna, Dresden, and in Paris, where it was revived in productions over the next 50 years.

Philippe Gille
Philippe Emile François Gille (10 December 1831 – 19 March 1901) was a French dramatist and opera librettist, who was born and died in Paris. He co-wrote wrote more than twenty librettos between 1857 and 1893, the most famous of which are Massenet's Manon and Delibes'  Lakmé.

Gille studied law and was a clerk for a time at the Préfecture de la Seine, before becoming secretary of the Théâtre Lyrique and, from 1869, an art and music critic for Le Figaro.

Gille was elected to the Académie des Beaux-Arts in 1899 and was appointed as an officer of the Legion of Honour.
Disciplina Tour
The Disciplina Tour was the fifth concert tour by Argentine singer Lali. The tour saw multiple songs performed for the first time live, including those from her fourth studio album, Libra (2020) and songs belonging to her fifth studio album, Lali (2023), such as "Disciplina", "Diva" and "N5". It began on 23 June 2022 and it travelled across Latin America, Europe and Asia, concluding on 8 April 2023.

In March 2023, Lali became the first Argentine woman to ever sold out the fifty-thousand-seat José Amalfitani Stadium with the Disciplina Tour. The show was broadcast live on the TV special Disciplina Tour Live from Buenos Aires on Star+ and Disney+.

Disciplina (song)
"Disciplina" (transl. "discipline") is a song recorded by Argentine singer Lali. The song was released by Sony Music Argentina on January 12, 2022, as the lead single from Lali's fifth studio album, Lali (2023). The song was written by Lali, Martín D'Agosto, Dano, and Mauro De Tommaso, and produced by the latter two.

The song received a nomination for Hottest Choreography (which stands for Best Choreography) at the Premios Juventud of 2022. Meanwhile, its music video won Best Music Video at the 2023 Gardel Awards.
Napoleon Road
Napoleon Road (French: La route Napoléon) is a 1953 French comedy film directed by Jean Delannoy and starring Pierre Fresnay, Henri Vilbert and Claude Laydu. It was partly shot at the Billancourt Studios in Paris. The film's sets were designed by the art director Serge Piménoff.

Claude Laydu
Claude Laydu ([klod lɛdy]; 10 March 1927 – 29 July 2011) was a Belgian-born Swiss actor on stage and in films. He was renowned for his performance in his film debut in the role of the young priest in Robert Bresson's Diary of a Country Priest (1951), which has been described as one of the greatest in the history of film.
Peace (1949 film)
Peace (Spanish: Paz) is a 1949 Spanish drama film directed by José Díaz Morales and starring Rafael Durán, Emilia Guiú and Alfredo Mayo. It was shot at the Roptence Studios in Madrid. The film's sets were designed by the art director Francisco Escriñá.

Emilia Guiú
Emilia Guiú Estivella (March 21, 1922 – February 7, 2004) was a Spanish actress who appeared mainly in Mexican films, particularly in the 1940s and 1950s in the Golden Age of Mexican cinema. She made over 60 film appearances between 1943 and 2000 and typically played villain roles and "femme fatale". She also made a number of theatrical appearances.
The Education of Pan
The Education of Pan is a lost c.1490 tempera on canvas painting by Luca Signorelli. It was in the Kaiser-Friedrich-Museum in Berlin but was moved to the Flakturm Friedrichshain during the Second World War. There it was destroyed in a fire in May 1945 just after the end of the war.

It was the most significant commission by Lorenzo the Magnificent and was described by Giorgio Vasari as a painting of "nude gods" painted for him by Signorelli. It was recorded at the Palazzo Pitti in 1687 and then moved to the Palazzo Corsi near San Gaetano in 1865.

The painting appears in Lina Waterfield's autobiography Castle in Italy, where she claims that ownership of the painting passed through her family in the late 19th Century before ending up in the Kaiser-Friedrich-Museum (later the Bode Museum) in Germany.: 39

Bode Museum
The Bode Museum (German: Bode-Museum), formerly called the Emperor Frederick Museum (German: Kaiser-Friedrich-Museum), is a listed building on the Museum Island in the historic centre of Berlin. It was built from 1898 to 1904 by order of German Emperor William II according to plans by Ernst von Ihne in Baroque Revival style. The building's front square featured a memorial to German Emperor Frederick III, which was destroyed by the East German authorities. Currently, the Bode-Museum is home to the Skulpturensammlung, the Museum für Byzantinische Kunst and the Münzkabinett (sculpture, Byzantine art, and coins and medals). As part of the Museum Island complex, the Bode-Museum was inscribed on the UNESCO World Heritage List in 1999 because of its outstanding architecture and testimony to the development of museums as a cultural phenomenon in the late 19th and early 20th centuries.
Silverwater (album)
Silverwater is the fifteenth album by Australian improvised music trio The Necks (their tenth excluding live and soundtrack albums), first released on the Fish of Milk label in 2009 in Australia and on the ReR label internationally. The album features a single track, titled "Silverwater", performed by Chris Abrahams, Lloyd Swanton and Tony Buck.

Tony Buck (musician)
Tony Buck (born 1962) is an Australian drummer and percussionist. He graduated from the New South Wales Conservatorium of Music (now Sydney Conservatorium of Music), becoming involved in the Australian jazz scene.

Buck played in Great White Noise with Michael Sheridan and Sandy Evans during 1983, then Women and Children First with Sandy Evans. He is a founding member of The Necks with Chris Abrahams and Lloyd Swanton since 1987. He is leader of Peril, who he formed in Japan with Otomo Yoshihide and Kato Hideki, and astroPeril.  He also formed the short lived L'Beato in the early 1990s, an industrial-oriented outfit reminiscent of Tackhead, which released one EP "The Piston Song".

In the early 1990s, Buck moved from Australia to Amsterdam and later moved to Berlin.
Matt O'Leary
Matthew Joseph O'Leary  (born July 6, 1987) is an American retired actor. He made his debut in the made-for-television Disney Channel Original film Mom's Got a Date with a Vampire (2000), and would go on to star in the thriller Domestic Disturbance (2001) opposite John Travolta. He also had supporting roles in Frailty (2001), and the independent neo-noir film Brick (2005).

In 2011, he starred opposite Rachael Harris in the critically acclaimed independent film Natural Selection, followed by a lead role in Fat Kid Rules the World (2012). He had a minor part in Gore Verbinski's The Lone Ranger (2013), and lead roles in the horror films Stung (2015) and Bokeh (2017).

Brick (film)
Brick is a 2005 American neo-noir mystery thriller film written, edited, and directed by Rian Johnson in his directorial debut, starring Joseph Gordon-Levitt. Brick was distributed by Focus Features, and opened in New York and Los Angeles on April 7, 2006. The film's narrative centers on a hardboiled detective story set in a California suburb. Most of the main characters are high school students. The film draws heavily in plot, characterization, and dialogue from hardboiled classics, especially those by Dashiell Hammett. The title refers to a block of heroin, compressed roughly to the size and shape of a brick.

The film won the Special Jury Prize for Originality of Vision at the 2005 Sundance Film Festival, and received positive reviews from critics. It has come to be regarded as a cult classic.
The Real Housewives of Sydney
The Real Housewives of Sydney (abbreviated RHOS) is an Australian reality television series that premiered on Arena on 26 February 2017. Developed as an international installment of the American The Real Housewives franchise and the third installment of the franchise by Matchbox Pictures, following The Real Housewives of Melbourne and The Real Housewives of Auckland. It has three seasons and focuses on the personal and professional lives of women living in Sydney, Australia.

The series was cancelled in 2019 following one season, however a revival was announced on 28 April 2023. New episodes premiered exclusively on streaming service Binge, and aired same-day on Arena.

Matchbox Pictures
Matchbox Pictures was a film and television production company headquartered in Sydney with production houses in Sydney, Melbourne, and Singapore. It was formed in 2008 by Tony Ayres, Penny Chapman, Helen Bowden, Michael McMahon and Helen Panckhurst. In 2011, NBCUniversal took a majority stake in Matchbox Pictures, and full ownership by January 2014.

Matchbox Pictures was led by Alastair McKinnon (managing director), Matthew Vitins (COO), Debbie Lee (Director of Scripted Development), Penny Chapman (Producer), Helen Panckhurst (Head of Production), Michael McMahon (Producer), and Kate O'Connell (Finance Director).

On 16 July 2018, Matchbox Pictures and NBCUniversal backed co-founder Tony Ayres' new company, Tony Ayres Productions.

On 17 February 2026, Universal International Studios announced that Matchbox Pictures will cease operations.
John G. Whilldin
The John G. Whilldin was a 19th-century Pennsylvania pilot schooner built in 1839 by the Joseph Vogle shipyard of Southwark, Philadelphia. In 1893, the Board of Port Wardens of Philadelphia recognized only four pilot boats for the Port of Philadelphia, the E. C. Knight, John G. Whilldin, William W. Ker and J. Henry Edmunds. On September 8, 1915, the Whilldin was reported as wrecked near Port St. Joe, Florida.

Port St. Joe, Florida
Port St. Joe or Port Saint Joe is a city and the county seat of Gulf County, Florida, United States. It is located at the intersection of U.S. Highway 98 and State Road 71. As of the 2020 census, the population was 3,357.
Bernard Fox (actor)
Bernard Lawson (11 May 1927 –  14 December 2016), better known as Bernard Fox, was a Welsh actor. He is remembered for his roles as Dr. Bombay in the comedy fantasy series Bewitched (1964–1972) of which he was the last surviving adult cast member, Colonel Crittendon in the comedy series Hogan's Heroes (1965–1971), Malcolm Merriweather in The Andy Griffith Show (1963–1965), Max in Herbie Goes to Monte Carlo (1977), and Archibald Gracie IV in the film Titanic (1997).

Archibald Gracie IV
Archibald Gracie IV (January 15, 1858 – December 4, 1912) was an American writer, soldier, amateur historian, real estate investor, and passenger aboard RMS Titanic. Gracie survived the sinking of the Titanic by climbing aboard an overturned collapsible lifeboat and wrote a popular book about the disaster. He never recovered from his ordeal and died less than eight months after the sinking, becoming the first adult survivor to die.
1925 KLM Fokker F.III Forêt de Mormal crash
On 25 June 1925, KLM-owned Fokker F.III H-NABM was a passenger flight from Schiphol Airport, the Netherlands to Paris, France. Due to bad weather it struck trees in the Forêt de Mormal and crashed. The pilot and all three passengers were killed.

It was the second fatal KLM accident after the 1924 KLM Fokker F.III disappearance.

Due to the impact of the crash, there were expectations that there would be a decrease in airplane tickets; not only for KLM but in general. The crash caused a public discussion about airliner insurance.

The crash is one of the most important events in the history of the region Locquignol, and was memorized still 100 years after the crash.

Forêt de Mormal
The Forêt de Mormal (Forest of Mormal) is a forest in France, near the Franco-Belgian border. It is best known to the British for its role in the retreat from Mons in August 1914. Its perceived lack of passable roads forced I and II Corps of the British army to divide and the two corps did not reunite for some days. However, some units of the British army did pass through the forest. The German army also passed through the forest, taking Haig's I Corps by surprise. It is the largest forest in the Nord area, at around 9000 hectares.