hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Taccalonolide
Taccalonolides are a class of microtubule-stabilizing agents isolated from Tacca chantrieri that has been shown to have selective cancer-fighting properties. Other examples of microtubule-stabilizing agents include taxanes and epothilones, both of which prevent cancer cells from dividing by interfering with tubulin. While taxanes like paclitaxel and docetaxel have been used successfully against breast, ovarian, prostate, and non–small-cell lung cancers, intrinsic and acquired drug resistance limit their anticancer properties. Unlike taxanes, taccalonolides appear to work through a different mechanism of action that does not involve tubulin, although recently isolated taccalonolides AF and AJ have shown tubulin-interaction activity. The discovery of taccalonolides opens up new possibilities to treat cancer cells, especially ones that are taxane- or epithilone-resistant.

Epothilone
Epothilones are a class of potential cancer drugs. Like taxanes, they prevent cancer cells from dividing by interfering with tubulin, but in early trials, epothilones have better efficacy and milder adverse effects than taxanes.

Epothilones were originally identified as metabolites produced by the soil-dwelling myxobacterium Sorangium cellulosum. As of September 2008, epothilones A to F have been identified and characterized.

Early studies in cancer cell lines and human cancer patients indicate superior efficacy to the taxanes.  Their mechanism of action is similar, but their chemical structure is simpler. Due to their better water solubility, cremophors (solubilizing agents used for paclitaxel which can affect cardiac function and cause severe hypersensitivity) are not needed. 
Endotoxin-like properties known from paclitaxel, like activation of macrophages synthesizing inflammatory cytokines and nitric oxide, are not observed for epothilone B.
Anubandha chatushtaya
Anubandha chatushtaya (Sanskrit: अनुबन्ध चतुष्टय) literally means four connections, and therefore, it is four-fold in nature and content viz, – a) adhikāri ('the qualified student') who has developed ekāgrata ('single pointed mind'), chitta shuddhi ('purity of the mind') and vikshepa ('freedom from restlessness and impurity') or adhikāra (aptitude); b) vishaya ('subject matter' or 'the theme') pertaining to the  Jiva-Brahman identity; c) prayojana or  phalasruti ('result' or 'fruit') which is atyantika-dukha-nivritti ('complete cessation of sorrow') and paramānanda-prāpti ('attainment of supreme happiness'), and d) sambandha ('relationship' or 'intertextuality') between adhikāra, vishaya and prayojana.

Vikṣepa
Vikṣepa (Sanskrit; Tibetan phonetic: nampar yengwa) is a Buddhist and Hindu term that is translated as "distraction", "mental wandering", etc. In the Mahayana tradition, vikṣepa is defined as the mental motion or wandering towards an object which causes the inability to remain one-pointedly on a virtuous objective.

Vikṣepa is identified as:

One of the twenty secondary unwholesome factors within the Mahayana Abhidharma teachings

One of the attributes of Maya in advaita vedanta. Adi Sankara mentions in his Viveka Choodamani (verse 113) that Vikshepa is an effect of Rajo Guna.
Karl Grünberg (otologist)
Karl Heinrich Grünberg (16 July 1875 in Stralsund – 25 November 1932 in Bonn) was a German otorhinolaryngologist, known for his research on the pathological anatomy of the ear's labyrinth.

He studied medicine at several German universities, receiving his doctorate in Greifswald in 1897 with the dissertation-thesis Fälle von perforierendem Sarkom des Schädels ("Two cases of perforating sarcoma of the skull"). In 1908 he obtained his habilitation for otology, rhinology and laryngology at the University of Rostock, where he later became an associate professor. From 1924 to 1932 he was a full professor of otorhinolaryngology at the University of Bonn.

Otorhinolaryngology
Otorhinolaryngology (/oʊtoʊˌraɪnoʊˌlærɪnˈɡɒlədʒi/ oh-toh-RY-noh-LARR-in-GOL-ə-jee, abbreviated ORL and also known as otolaryngology, otolaryngology – head and neck surgery (ORL–H&N or OHNS), or ear, nose, and throat (ENT) ) is a surgical subspecialty within medicine that deals with the surgical and medical management of conditions of the head and neck. Doctors who specialize in this area are called otorhinolaryngologists, otolaryngologists, head and neck surgeons, or ENT surgeons or physicians.

Patients seek treatment from an otorhinolaryngologist for diseases of the ear, nose, throat, base of the skull, head, and neck. These commonly include functional diseases that affect the senses and activities of eating, drinking, speaking, breathing, swallowing, and hearing. In addition, ENT surgery encompasses the surgical management of cancers and benign tumors and reconstruction of the head and neck as well as plastic surgery of the face, scalp, and neck.
Matt Swarmer
Matthew Lee Swarmer (born September 25, 1993) is an American professional baseball pitcher for the Lancaster Stormers of the Atlantic League of Professional Baseball. He has previously played in Major League Baseball (MLB) for the Chicago Cubs.

Lancaster Stormers
The Lancaster Stormers (formerly known as the Lancaster Barnstormers) are an American professional baseball team based in Lancaster, Pennsylvania. They are members of the North Division of the Atlantic League of Professional Baseball, a "partner league" of Major League Baseball. Since 2005, the team has played its home games at Penn Medicine Park in the city's Northwest Corridor, following the stadium's completion.
Alyth Railway
The Alyth Railway was a short branch railway line built in Strathmore in Scotland, connecting the town of Alyth to the main line network. It opened in 1861. Its junction was remote from any large population centre except Dundee, which was only reached by a primitive line with three rope worked inclines. This was modernised in 1868 and the Alyth branch, now with a good connection to Dundee, became busy. Nonetheless, the population of Alyth declined, and so did usage of the line, and it closed in 1951.

Caledonian Railway
The Caledonian Railway (CR) was one of the two biggest of the five major Scottish railway companies prior to the 1923 Grouping. It was formed in 1845 with the objective of forming a link between English railways and Glasgow. It progressively extended its network and reached Edinburgh and Aberdeen, with a dense network of branch lines in the area surrounding Glasgow. It was absorbed into the London, Midland and Scottish Railway in 1923. Many of its principal routes are still used, and the original main line between Carlisle and Glasgow is in use as part of the West Coast Main Line railway (with a modified entry into Glasgow itself).
James Renforth
James Renforth  (7 April 1842 – 23 August 1871) was an English Tyneside professional oarsman. He became the World Sculling Champion in 1868 and was one of three great Tyneside oarsmen, the other two being Harry Clasper and Robert Chambers.

Sculling
Sculling is the use of oars to propel a boat by moving them through the water on both sides of the craft, or moving one oar over the stern. A long, narrow boat with sliding seats, rigged with two oars per rower may be referred to as a scull, its oars may be referred to as sculls and a person rowing it referred to as sculler.

Sculling is distinguished from sweep rowing, whereby each boat crew member employs an oar, complemented by another crew member on the opposite side with an oar, usually with each pulling it with two hands and from stern sculling, which uses an oar to propel a vessel with side-to-side movements from the stern.
Jean Darricau
Jean Darricau, (born 2 October 1931) is a French former rugby union and league footballer in the 1940s, 1950s and 1960s. He played as centre or lock forward.

After his debut in rugby union for US Dax with which he won the Frantz Reichel Cup in 1949 and 1950, then a stint at SBUC, he switched codes in 1952 to join rugby league and Bordeaux, with which he won the French Championship in 1954. Later, he joined the Lyon club.

Thanks to his performances, he was called up twice for the France national team in 1957 to face Great Britain, and was called up for the 1960 tour.

US Dax
Union Sportive Dax Rugby Landes, also known as US Dax, is a French rugby union club currently playing in Pro D2, the second level of the French league system.

They were founded in 1904. They play at Stade Maurice Boyau (capacity 7,262). They wear red and white. They are based in Dax in the Landes department  of Nouvelle-Aquitaine.
1150 Achaia
1150 Achaia (/əˈkaɪə/); prov. designation: 1929 RB) is a stony background asteroid from the inner regions of the asteroid belt. It was discovered by Karl Reinmuth at Heidelberg Observatory on 2 September 1929. The S-type asteroid has a notably long rotation period of hours 61 hours and measures approximately 7.8 kilometers (4.8 miles) in diameter. It is named for the Greek region of Achaia.

Achaea
Achaea (/əˈkiːə/) or Achaia (/əˈkaɪə/), sometimes transliterated from Greek as Akhaia (Αχαΐα, Akhaḯa, Greek: [axaˈia]), is one of the regional units of Greece. It is part of the region of Western Greece and is situated in the northwestern part of the Peloponnese peninsula. The capital is Patras which is the third largest city in Greece.
Henry Pollock
Sir Henry Edward Pollock, QC, JP (Chinese: 普樂, 16 December 1864 – 2 February 1953) was an English barrister who became a prominent politician in Hong Kong. He acted as Attorney General in Hong Kong on several occasions, and was once appointed to the same post in Fiji. He also served as Senior Unofficial Member of both the Legislative Council and Executive Council for many years in pre-Pacific War Hong Kong. Along with Sir Paul Chater, then Governor Sir Frederick Lugard (later Lord Lugard) and others, Sir Henry was one of the founders of the University of Hong Kong.

Secretary for Justice
The secretary for justice (Chinese: 律政司司長) is the head of the Hong Kong Department of Justice, the chief legal advisor to the chief executive of Hong Kong and the government, and the chief law enforcement officer of the Government of Hong Kong. Before the transfer of sovereignty over Hong Kong in 1997, the position was known as the Attorney-General of Hong Kong.

Like all other principal officials, the secretary for justice is appointed by the Central Government on the nomination of the Chief Executive, and is an official member of the Executive Council. The position is normally held by a legal professional, and was before July 2002 a civil service position. The secretary for justice, after the chief secretary and the financial secretary, is the third highest ranking principal official of the Government.

The current secretary for justice is Paul Lam, GBS, SC, JP.
Pheres (son of Cretheus)
In Greek mythology, Pheres (Ancient Greek: Φέρης, Phéres, modern pronunciation Féris; Latin: Pheres) is the son of Cretheus and Tyro, and the brother of Aeson and Amythaon. In the Bibliotheca of Apollodorus, he is said to be the founder of Pherae in Thessaly.

In the Fabulae, he is said to be the father of Admetus by Periclymene. In addition to Admetus, Apollodorus calls Lycurgus, Idomene, and Periopis children of Pheres.

Bibliotheca (Apollodorus)
The Bibliotheca (Ancient Greek: Βιβλιοθήκη, romanized: Bibliothēkē, lit. 'Library') is a compendium of Greek myths and heroic legends, genealogical tables and histories arranged in three books, generally dated to the first or second century AD. The work is commonly described as having been written by Apollodorus (or sometimes Pseudo-Apollodorus), a result of its false attribution to the 2nd-century BC scholar Apollodorus of Athens.
Placentia West-Bellevue
Placentia West-Bellevue is a provincial electoral district in Newfoundland and Labrador, Canada, which is represented by one member in the Newfoundland and Labrador House of Assembly. It was contested for the first time in the 2015 provincial election.

The district was created following the 2015 redistribution which saw the elimination of the district of Bellevue. The district was largely preceded by the district of Burin-Placentia West which was abolished in 2015. Marystown is the largest population centre in the district.

The district contains an intra-provincial ferry servicing South East Bight.

Newfoundland and Labrador House of Assembly
The Newfoundland and Labrador House of Assembly (French: Chambre d'assemblée de Terre-Neuve-et-Labrador) is the unicameral deliberative assembly of the General Assembly of Newfoundland and Labrador of the province of Newfoundland and Labrador, Canada. It meets in the Confederation Building in St. John's. Bills passed by the assembly are given royal assent by the lieutenant governor of Newfoundland and Labrador, in the name of the Sovereign.

The governing party sits on the left side of the speaker of the House of Assembly as opposed to the traditional right side of the speaker. This tradition dates back to the 1850s as the heaters in the Colonial Building were located on the left side. Thus, the government chose to sit near the heat, and leave the opposition sitting in the cold.
Ghost World (The Vampire Diaries)
"Ghost World" is the seventh episode of the third season of The CW television series, The Vampire Diaries and the 51st episode of the series overall. It originally aired on October 27, 2011. The episode was written by Rebecca Sonnenshine and directed by David Jackson.

The Vampire Diaries season 3
The Vampire Diaries, an American supernatural drama, was officially renewed for a third season by the CW on April 26, 2011. The season aired from September 15, 2011, to May 10, 2012, and consisted of 22 episodes. The plot focused on the story of Klaus' origin, his relation with his family and revealed more about the Original family. The third season opened to generally positive reviews. The season takes a gap from the last season and begins with Elena Gilbert's 18th birthday, with all series regulars returning with the exception of Sara Canning, whose character, Jenna Sommers, was killed off in the previous season. Joseph Morgan's character Klaus became a series regular after previously appearing in a recurring role.
Adolf Neuendorff
Adolf Heinrich Anton Magnus Neuendorff (June 13, 1843 − December 4, 1897), also known as Adolph Neuendorff, was a German-American composer, violinist, pianist and conductor, stage director, and theater manager.

Theodore Thomas (conductor)
Theodore Thomas (October 11, 1835 – January 4, 1905) was a German-American violinist, conductor, and orchestrator. He is considered the first renowned American orchestral conductor and was the founder and first music director of the Chicago Symphony Orchestra (1891–1905).
Waxworks (1924 film)
Waxworks (German: Das Wachsfigurenkabinett) is a 1924 German silent anthology film directed by Paul Leni. Its stories are linked by a plot thread about a writer (William Dieterle) who accepts a job from a waxworks proprietor to write a series of stories about the exhibits of Caliph of Baghdad (Emil Jannings), Ivan the Terrible (Conrad Veidt) and Jack the Ripper (Werner Krauss) in order to boost business.

Wax museum
A wax museum or waxworks usually consists of a collection of wax sculptures representing famous people from history and contemporary personalities exhibited in lifelike poses, wearing real clothes.

Some wax museums have a special section dubbed the "Chamber of Horrors", in which the more grisly exhibits are displayed. Some collections are more specialized, as, for example, collections of wax medical models once used for training medical professionals. Many museums or displays in historical houses that are not wax museums as such use wax figures as part of their displays. The origin of wax museums goes back to the early 18th century at least, and wax funeral effigies of royalty and some other figures exhibited by their tombs had essentially been tourist attractions well before that.
Kevin M. Sligh Sr.
Kevin Maurice Sligh, Sr. was the director of the Bureau of Safety and Environmental Enforcement from March 2022 to September 2024. Sligh is the first African American to lead BSEE. He was previously the deputy regional administrator of the Federal Emergency Management Agency. (FEMA) Region 5 located in Chicago, Illinois from 2020 to 2021.

Bureau of Safety and Environmental Enforcement
The Bureau of Safety and Environmental Enforcement (BSEE /ˈbɛsi/ "Bessie") is an agency under the United States Department of the Interior.

Established in 2011, the agency is responsible for improving safety and ensuring environmental protection in the offshore energy industry, mainly natural gas and oil, on the United States Outer Continental Shelf (OCS). The agency oversees the safety and environmental enforcement functions formerly under the Minerals Management Service, including the authority to inspect, investigate, summon witnesses, produce evidence, levy penalties, cancel or suspend activities, oversee safety, response, and removal preparedness.
Crocosmia
Crocosmia (/krəˈkɒzmiə, kroʊ-/), also known as montbretia (/mɒnˈbriːʃə/), is a small genus of flowering plants in the iris family, Iridaceae. It is native to the grasslands of southern and eastern Africa, ranging from South Africa to Sudan. One species is endemic to Madagascar.

Crocosmia × crocosmiiflora
Crocosmia × crocosmiiflora, or montbretia, is a garden hybrid of C. aurea and C. pottsii, first bred in 1880 in France by Victor Lemoine. The basionym of the hybrid is Montbretia crocosmiiflora Lemoine. In 1932 it was reclassified as C. × crocosmiiflora (Lemoine) N.E.Br., but the common name "montbretia" is still often found in horticultural literature, and is commonly used in the British Isles for orange-flowered cultivars that have naturalised, while "crocosmia" is reserved for less aggressive red-flowered cultivars.
Cannabinoid receptor 2
The cannabinoid receptor 2 (CB2), is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene. It is closely related to the cannabinoid receptor 1 (CB1), which is largely responsible for the efficacy of endocannabinoid-mediated presynaptic-inhibition, the psychoactive properties of tetrahydrocannabinol (THC), the active agent in cannabis, and other phytocannabinoids (plant cannabinoids). The principal endogenous ligand for the CB2 receptor is 2-Arachidonoylglycerol (2-AG).

CB2 was cloned in 1993 by a research group from Cambridge looking for a second cannabinoid receptor that could explain the pharmacological properties of tetrahydrocannabinol. The receptor was identified among cDNAs based on its similarity in amino acid sequence to the CB1 receptor, discovered in 1990. The discovery of this receptor helped provide a molecular explanation for the established effects of cannabinoids on the immune system.

2-Arachidonoylglycerol
2-Arachidonoylglycerol (2-AG) is an endocannabinoid, an endogenous agonist of the CB1 receptor and the primary endogenous ligand for the CB2 receptor. It is an ester formed from the omega-6 fatty acid arachidonic acid and glycerol. It is present at relatively high levels in the central nervous system, with cannabinoid neuromodulatory effects. It has been found in bovine and human milk. The chemical was first described in 1994–1995, although it had been discovered some time before that. The activities of phospholipase C (PLC) and diacylglycerol lipase (DAGL) mediate its formation. 2-AG is synthesized from arachidonic acid-containing diacylglycerol (DAG).
Jarrad Butler
Jarrad Butler (born 20 July 1991) is an Australian professional rugby union player. He primarily plays as a flanker but also plays at number 8. Butler currently plays for Irish provincial side Connacht in the Pro14. Before joining Connacht, Butler played in Super Rugby, first for the Reds and then for the Brumbies. While playing for the Brumbies, Butler also played for National Rugby Championship the Canberra Vikings, where he served as captain.

Born in Wellington, New Zealand Butler moved to Australia at 13, and has represented the country at under-age level. He played for the Australia schoolboys team in 2008 and the under-20 side in 2010. Butler has also played for international invitational side, the Barbarians.

Australian Schoolboys rugby union team
The Australian Schoolboys & U18 rugby union team is the national team for schoolboy rugby union & U18 players in Australia.  Considered to be the pinnacle of schoolboy & U18 rugby in Australia, the team plays in fixtures against other national representative schoolboy teams from around the world. Many players who have played in the Australian Schoolboys team have gone on to further representative careers with Super Rugby franchise teams and the Australian national rugby union team.
Decision-to-decision path
A decision-to-decision path, or DD-path, is a path of execution (usually through a flow graph representing a program, such as a flow chart) between two decisions. More recent versions of the concept also include the decisions themselves in their own DD-paths.

Flowchart
A flowchart is a type of diagram that represents a workflow or process. A flowchart can also be defined as a diagrammatic representation of an algorithm, a step-by-step approach to solving a task.

The flowchart shows the steps as boxes of various kinds, and their order by connecting the boxes with arrows. This diagrammatic representation illustrates a solution model to a given problem. Flowcharts are used in analyzing, designing, documenting or managing a process or program in various fields.
Budweiser Budvar Brewery
Budweiser Budvar (Czech: Budějovický Budvar [ˈbuɟɛjovɪtskiː ˈbudvar]) is a brewery in the Czech city of České Budějovice (German: Budweis), best known for its original Budweiser or Budweiser Budvar pale lager brewed using artesian water, Moravian barley and Saaz hops. Budweiser Budvar is the fourth largest beer producer in the Czech Republic and the second largest exporter of beer abroad.

The state-owned brewery and its Budweiser pale lager have been engaged in a trademark dispute with Anheuser-Busch over the right to market and sell the beer under the name Budweiser since the start of the 20th century, and consequently is imported as Czechvar in some countries. The brewery is incorporated as Budějovický Budvar, národní podnik ("Budweiser Budvar, national enterprise").

Pale lager
Pale lager is a pale-to-golden lager beer with a well-attenuated body and a varying degree of noble hop bitterness.

In the mid-19th century, Gabriel Sedlmayr took British pale ale brewing and malt making techniques back to the Spaten Brewery in Germany and applied them to existing lagering methods. The resulting beers gradually spread around the globe to become the most common form of beer consumed in the world today.
Tihomir Kostadinov
Tihomir Kostadinov (Macedonian: Тихомир Костадинов; born 4 March 1996) is a Macedonian professional footballer who plays as a midfielder for Czech First League club Slovácko on loan from Sigma Olomouc, and the North Macedonia national team.

North Macedonia national football team
The North Macedonia national football team (Macedonian: Фудбалска репрезентација на Македонија, romanized: Fudbalska reprezentacija na Makedonija) represents North Macedonia in men's international football. It is administered by the Football Federation of Macedonia. The team plays their home matches at the Toše Proeski National Arena in Skopje.

North Macedonia has reached Euro 2020 (its first major tournament) and the European qualifying play-off final of the 2022 World Cup (after defeating Germany in Duisburg and Italy in Palermo).