hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Stem-cell therapy
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood. Research is underway to develop various sources for stem cells as well as to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes and heart disease.

Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer, and their use of techniques to create induced pluripotent stem cells. This controversy is often related to abortion politics and  human cloning. Additionally, efforts to market treatments based on transplant of stored umbilical cord blood have been controversial.

Mesenchymal stem cell
Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or medicinal signaling cells, are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue).

The primary function of MSCs is to respond to injury and infection by secreting and recruiting a range of biological factors, as well as modulating inflammatory processes to facilitate tissue repair and regeneration. Extensive research interest has led to more than 80,000 peer-reviewed papers on MSCs.
Take 6
Take 6 is an American a cappella gospel sextet formed in 1980 on the campus of Oakwood College in Huntsville, Alabama. The group integrates jazz with spiritual and inspirational lyrics. Take 6 has received several Grammy Awards as well as Dove Awards, a Soul Train Award and nominations for the NAACP Image Award.

The band has worked with Ray Charles, Joe Sample, Nnenna Freelon, Gordon Goodwin, Don Henley, Whitney Houston, Al Jarreau, Quincy Jones, k.d. lang, Queen Latifah, The Manhattan Transfer, Johnny Mathis, Brian McKnight, Luis Miguel, Marcus Miller, Joe Sample, Ben Tankard, Randy Travis, CeCe Winans, Stevie Wonder and Jacob Collier. All original members grew up in the Seventh-day Adventist Church.

Al Jarreau
Alwin Lopez Jarreau (March 12, 1940 – February 12, 2017) was an American singer. His 1981 album Breakin' Away spent two years on the Billboard 200 and is considered one of the finest examples of the Los Angeles pop and R&B sound. The album won Jarreau the 1982 Grammy for Best Male Pop Vocal Performance. In all, he won ten Grammy Awards and was nominated 19 other times during his career.

Jarreau also sang the theme song of the 1980s television series Moonlighting and was among the performers on the 1985 charity song "We Are the World".
Koko ni wa Nai Mono
"Koko ni wa Nai Mono" (ここにはないもの; lit. "What Is Not Here") is a song recorded by Japanese idol girl group Nogizaka46. It was released as the group's thirty-first single on December 7, 2022, through N46Div. and Sony Music Records. First-generation member Asuka Saitō served as her eighth center position of the performance since the latest 2019 single "Sing Out!" and participated as her last single from the group. Its accompanying music video premiered ahead on November 19. Commercially, "Koko ni wa Nai Mono" reached number one on the Oricon Singles Chart and number two on the Billboard Japan Hot 100, and was certified million by Recording Industry Association of Japan (RIAJ).

Recording Industry Association of Japan
The Recording Industry Association of Japan (RIAJ) (日本レコード協会, Nihon Rekōdo Kyōkai) is an industry trade group composed of Japanese corporations involved in the music industry. It was founded in 1942 as the Japan Phonogram Record Cultural Association, and adopted its current name in 1969.

The RIAJ's activities include promotion of music sales, enforcement of copyright law, and research related to the Japanese music industry. It publishes the annual RIAJ Year Book, a statistical summary of each year's music sales, as well as distributing a variety of other data.

Headquartered in Minato, Tokyo, the RIAJ has twenty member companies and a smaller number of associate and supporting members; some member companies are the Japanese branches of multinational corporations headquartered elsewhere.

The association is responsible for certifying gold and platinum albums and singles in Japan.
Dalosirvat
Dalosirvat (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name; developmental code name SM-04554) is a drug acting as a Wnt signaling pathway stimulant which is under development for the treatment of alopecia (hair loss). It is used topically as a solution. The drug is being developed by Biosplice Therapeutics (formerly known as Samumed). As of April 2021, it is in phase 2/3 clinical trials for this in Turkey. There have been no further updates on the development of dalosirvat as of October 2025. Two phase 2 trials have been completed and preliminary results released. In one of the trials, only a 0.15% concentration and not a higher 0.25% concentration showed effectiveness. A 625-patient phase 3 trial was reportedly started in 2018. It was reported in a 2023 literature review that dalosirvat had completed a phase 3 trial in early 2023 and that Biosplice Therapeutics had cancelled its development based on the trial's results.

Phases of clinical research
The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases start with testing for drug safety in a few human subjects, then expand to many study participants (potentially tens of thousands) to determine if the treatment is effective. Clinical research is conducted on drug candidates, vaccine candidates, new medical devices, and new diagnostic assays.
Quilby Creek
Quilby Creek is a headwater of the Mobile River, whose source is in the U.S. state of Mississippi. The creek flows Northeast for around 4 miles (6.4 km), crossing the border into Sumter County, Alabama for the last third of its length, after which it empties into Bodka Creek.

Quilby is thought to be an Anglicization of the Choctaw koi ai ʋlbi. There is room for ambiguity in a translation, which could be "place where the lion was killed" or "place where the lion was trapped". The Alabama historian Robert D. Spratt reported the creek's name using the Choctaw word ʋlbi, which has several meanings centering on the nouns "trap" or "snare". The intended or original word was possibly ʋbi, the transitive verb "to kill". This distinction may be accidental or might specify the manner of the mountain lion's death. Variant names are "Koilbah Creek", "Quibby Creek", and "Quillibee Creek".

Bodka Creek
Bodka Creek is a stream in the U.S. states of Alabama and Mississippi.

Bodka Creek is a name derived from the Choctaw language meaning "wide creeks", a reference to its many branches. Variant names are "Bodca Creek", "Bodea Creek", and "Bodkars Creek".
Murder of Tess Richey
Tess Richey (30 November 1994 – 25 November 2017) was a Canadian woman who was killed after a Friday night out with a friend in the Church and Wellesley neighbourhood of Toronto. Four days after she had disappeared, her body was discovered by her mother at the bottom of an outdoor stairwell two houses from where she was last seen. A homicide investigation led to the arrest of Kalen Schlatter, who has been convicted of first-degree murder.

The Toronto Police Service (TPS) was criticized for failing to find the body when it was so close to where Richey had disappeared.  TPS Chief Mark Saunders quickly ordered an internal review of her case, and later recommended an external review of how the TPS conducts missing persons investigations.  Richey's death, along with the deaths of other missing persons at Church and Wellesley, led the TPS to create a dedicated missing-persons unit.

Mark Saunders (police officer)
Mark Saunders OOM (born 1962) is a Canadian politician and retired police officer who served as chief of police with the Toronto Police Service (TPS) from 2015 to 2020.

Saunders was the Progressive Conservative (PC) candidate in Don Valley West in the 2022 Ontario election where he finished second behind Liberal candidate Stephanie Bowman. Saunders was a candidate for mayor of Toronto in the 2023 by-election, where he came in third, to winner Olivia Chow and runner-up Ana Bailão. Saunders' candidacy was described as a "law and order" campaign.
Dundee Brewing Company
Dundee was a Rochester, New York–based brewing company that produced ales and lagers. It was part of the Genesee Brewing Company, owned by North American Breweries (now FIFCO USA ) which started marketing the brand's first lager in 1994 as J.W. Dundee's Honey Brown. Honey Brown quickly gained a good reputation and won awards, most notably the gold medal at the 2004 World Beer Cup.

The company produced one year-round craft beer, India Pale Ale, as well as eight craft beers available in seasonal variety packs: English-Style Ale, Kölsch-Style Ale, Pale Ale, Pale Bock, Pilsner, Porter and Stout.

The company also produced four seasonal craft beers: Irish Red Lager (Spring), Summer Shandy (Summer), Oktoberfest (Fall), Nut Brown Ale (Winter).

On October 29, 2020, Genesee Brewing announced the rebranding of Original Honey Brown Lager, their last product still bearing the J.W. Dundee brand, to Genesee Specialty.

Genesee Brewing Company
Genesee Brewing Company (/ˈdʒɛnəsi/ JEN-ə-see) is an American brewery located along the Genesee River in Rochester, New York. From 2000 to 2009, the company was known as the High Falls Brewing Company. In 2009, High Falls was acquired by the capital investment firm KPS Capital. Together with newly acquired Labatt USA, KPS merged the two companies as North American Breweries. Along with this change, High Falls Brewery changed its name back to the original "Genesee Brewing Company" operating under the North American Breweries name. In October 2012, North American Breweries was purchased by FIFCO.

In 2012, North American Breweries was the sixth-largest brewing company in America by sales volume.
Alive: The Final Evolution
Alive: The Final Evolution (Japanese: アライブ -最終 進化的 少年-, Hepburn: Araibu Saishū Shinkateki Shōnen; lit. 'Alive: Last Evolutionary Boy') is a Japanese manga series written by Tadashi Kawashima and illustrated by Adachitoka. It was serialized in Kodansha's shōnen manga magazine Monthly Shōnen Magazine from April 2003 to February 2010; it was Kawashima's last work before his death in June of that same year. Its chapters were collected in 21 tankōbon volumes. In North America, Del Rey Manga licensed series for an English localization and released eight volumes. In July 2016, Kodansha USA took over North American release of the series digitally only.

An anime adaptation for the series was planned and to be produced by Gonzo and co-produced by Anime International Company, but the adaptation was canceled due to Gonzo being delisted from the Tokyo Stock Exchange.

Kodansha USA
Kodansha USA Publishing, LLC is a publishing company based in New York, US, and a subsidiary of Japan's largest publishing company Kodansha. Established in July 1st 2008, Kodansha USA publishes books relating to Japan, Japanese culture, and manga, the latter under their Kodansha Manga imprint (formerly Kodansha Comics).

In 2020, Kodansha announced that it had consolidated Kodansha Advanced Media and Vertical into Kodansha USA Publishing, with Kodansha Advanced Media general manager Alvin Lu becoming the president and CEO of Kodansha USA Publishing.

On March 9, 2021, Kodansha USA Publishing announced it had rebranded and relaunched its website, and unified Kodansha Comics, Kodansha USA International, and Vertical under the Kodansha name, and Kodansha Comics being renamed Kodansha Manga.
Hold Me While I'm Naked
Hold Me While I'm Naked is a 1966 American underground short 16 mm film directed by George Kuchar. It stars Kuchar, Donna Kerness, Stella Kuchar, and Andrea Lunin. The most popular and acclaimed of Kuchar's filmography of over 200 films – it was voted 52nd in Village Voice's Critics' Poll of the 100 Best Films of the 20th Century.

16 mm film
16 mm film is a historically popular and economical gauge of film. 16 mm refers to the width of the film (about 2⁄3 inch); other common film gauges include 8 mm and 35 mm. It is generally used for non-theatrical (e.g., industrial, educational, television) film-making, or for low-budget motion pictures. It also existed as a popular amateur or home movie-making format for several decades, alongside 8 mm film and later Super 8 film. Eastman Kodak released the first 16 mm "outfit" in 1923, consisting of a Ciné-Kodak camera, Kodascope projector, tripod, screen and splicer, for US$335 (equivalent to US$6,330 in 2025).: 334  RCA-Victor introduced a 16 mm sound movie projector in 1932, and developed an optical sound-on-film 16 mm camera, released in 1935.: 231
Hélio Uchôa Cavalcanti
Hélio Uchôa Cavalcanti (1919–1971) was a Brazilian architect who contributed significantly to Brazilian national architecture and its modernist renewal. He collaborated with Oscar Niemeyer on projects like Rio de Janeiro's Lagoa Hospital and São Paulo's Ibirapuera Park, contributed to Brasilia's construction, and designed various residences and hotels globally.

Hélio Lage Uchôa Cavalcanti was born in Rio de Janeiro, Brazil on April 3, 1913 and graduated from the National School of Fine Arts in Rio de Janeiro in 1934. Throughout his career, he collaborated with prominent architects such as Affonso Eduardo Reidy and Oscar Niemeyer.

Some of Cavalcanti's notable projects include the Conjunto Residencial da Várzea do Carmo, the Duchen Factory, Palácio das Indústrias, Palácio das Nações, and Palácio dos Estados in Ibirapuera.

Cavalcanti died on January 22, 1971, in Rio de Janeiro, Brazil, at the age of 57.

Affonso Eduardo Reidy
Affonso Eduardo Reidy (Paris, 26 October 1909 - Rio de Janeiro, 10 August 1964) was a Brazilian architect. He was the son of an English father and a Brazilian mother. Reidy entered the Escola Nacional de Belas Artes in Rio de Janeiro at age 17. He apprenticed with the French urban planner Alfred Agache (1875-1959) during his studies. Reidy graduated and became an architect in 1930. Lúcio Costa appointed him as a teaching assistant to the architect Gregori Warchavchik (1896-1972) at the Escola Nacional de Belas Artes in the same year.
2009 Tour of California
The 2009 Tour of California was the 4th running of the Tour of California, an annual cycling race contained within the state of California. The event was staged February 14–22 and began with a prologue in the state capital of Sacramento. The event was held as part of the schedule of both the UCI America Tour and USA Cycling Professional Tour. The race was won by Levi Leipheimer for the third consecutive year.

2009 USA Cycling Professional Tour
The 2009 USA Cycling Professional Tour is the third year of this elite men's professional road bicycle racing series organized by USA Cycling.

Christian Vande Velde (272 points) and the Garmin/Chipotle Pro Cycling Team (711 points) are the defending champion of the overall individual and team titles, respectively.
Back in the Saddle (film)
Back in the Saddle is a 1941 American Western film directed by Lew Landers and starring Gene Autry, Smiley Burnette, and Mary Lee. Written by Richard Murphy and Jesse Lasky Jr., the film is about a singing cowboy who attempts to bring peace between ranchers and the operator of a copper mine whose chemicals are poisoning the area's water supply. The film features several of Autry's hit songs, including "Back in the Saddle Again", "I'm An Old Cowhand", and "You Are My Sunshine".

Mary Lee (actress)
Mary Lee (October 24, 1924 – June 6, 1996) was a big band singer and B movie actress from the late 1930s into the 1940s, appearing mostly in Westerns. She did not make any screen appearances after 1944.
Adrenocortical hormone
In humans and other animals, the adrenocortical hormones are hormones produced by the adrenal cortex, the outer region of the adrenal gland. These polycyclic steroid hormones have a variety of roles that are crucial for the body's response to stress (for example, the fight-or-flight response), and they also regulate other functions in the body. Threats to homeostasis, such as injury, chemical imbalances, infection, or psychological stress, can initiate a stress response. Examples of adrenocortical hormones that are involved in the stress response are aldosterone and cortisol. These hormones also function in regulating the conservation of water by the kidneys and glucose metabolism, respectively.

Adrenal cortex
The adrenal cortex is the outer region and also the largest part of the adrenal gland. It is divided into three separate zones: zona glomerulosa, zona fasciculata and zona reticularis. Each zone is responsible for producing specific hormones. It is also a secondary site of androgen synthesis.
Methanocaldococcus sp. FS406-22
Methanocaldococcus sp. FS406-22 is an archaea in the genus Methanocaldococcus. It is an anaerobic, piezophilic, diazotrophic, hyperthermophilic marine archaeon. This strain is notable for fixing nitrogen at the highest known temperature of nitrogen fixers recorded to date. The 16S rRNA gene of Methanocaldococcus sp. FS406-22, is almost 100% similar to that of Methanocaldococcus jannaschii, a non-nitrogen fixer.

Hyperthermophile
A hyperthermophile is an organism that thrives in extremely hot environments—from 60 °C (140 °F) upward. An optimal temperature for the existence of hyperthermophiles is often above 80 °C (176 °F). Hyperthermophiles are often within the domain Archaea, although few bacterial examples exist. Some of them are able to live at temperatures greater than 100 °C (212 °F), deep in the ocean where high pressures increase the boiling point of water. Many hyperthermophiles are also able to withstand other environmental extremes, such as high acidity or high radiation levels. Hyperthermophiles are a subset of extremophiles. Their existence may support the possibility of extraterrestrial life, showing that life can thrive in environmental extremes.
Vincent Fremont
Vincent Fremont (born 1950) is an American art magazine publishing executive, film director, and producer.

Fremont served as president of Andy Warhol Enterprises and, following Warhol's death in 1987, was a founding director of the Andy Warhol Foundation for the Visual Arts and a sales agent for the foundation. He later served on the Andy Warhol Art Authentication Board. In television, Fremont produced Andy Warhol's TV (1980–83) and Andy Warhol's Fifteen Minutes (1985–87). In film, he was an associate producer of Slaves of New York (1989) and co-directed and co-produced Pie in the Sky: The Brigid Berlin Story (2000). He was named CEO of ARTnews, Ltd. in 2016, stepping down the following year while remaining as an advisor.

ARTnews
ARTnews is an American online arts magazine based in New York City, formerly issued in print. Founded in 1902 and now the oldest art publication in the world, it covers visual arts from ancient to contemporary times. The publication includes news dispatches from correspondents, investigative reports, exhibition reviews, and profiles of artists and art collectors. Originally a print magazine issued at varying frequencies throughout its history, ARTnews transitioned to a digital publication and ceased its monthly and quarterly print issues in the 2010s and 2020s after a series of ownership changes that included merging with the magazine Art in America.
Danny Handling
Daniel Handling (born 6 February 1994) is a Scottish footballer who plays for Tranent Juniors. Handling has previously played for Hibernian and Dumbarton as well as Berwick Rangers and Raith Rovers on loan.

Berwick Rangers F.C.
Berwick Rangers Football Club is a football team based in the town of Berwick-upon-Tweed in England, who play in the Scottish football system. Founded in 1884, they currently play in the Lowland League, the fifth tier of Scottish football, despite being based in England. They were the only club from outside Scotland in the Scottish Professional Football League until their relegation in 2019.
Coregonus fontanae
Coregonus fontanae, also known as the Stechlin cisco, Fontane cisco, or Fontane's cisco, is a putative species of freshwater whitefish in the family Salmonidae endemic to the Großer Stechlinsee in northern Germany. It is believed to have recently evolved from the sympatric vendace, Coregonus albula.

Sympatry
In biology, two closely related species or populations are considered sympatric when they exist in the same geographic area and thus frequently encounter each other. An initially interbreeding population that splits into two or more distinct species sharing a common range exemplifies sympatric speciation. Such speciation may be a product of reproductive isolation – which prevents hybrid offspring from being viable or able to reproduce, thereby reducing gene flow – that results in genetic divergence. Sympatric speciation may, but need not, arise through secondary contact, which refers to speciation or divergence in allopatry followed by range expansions leading to an area of sympatry. Sympatric species or taxa in secondary contact may or may not interbreed.
Ayala Malls
Ayala Malls is a retail subsidiary of real estate company Ayala Land, an affiliate of Ayala Corporation. Founded in 1988, Ayala Malls owns a chain of large shopping malls, all located in the Philippines. It is one of the largest shopping mall retailers in the Philippines, alongside SM Supermalls and Robinsons Malls.

Ayala Land
Ayala Land, Inc. (ALI) is a full line real estate firm based in the Philippines. It is a subsidiary of Ayala Corporation. It began as a division of Ayala Corporation until it was spun off and incorporated in 1988. It became publicly listed in the Philippine Stock Exchange (PSE: ALI) in July 1991. Its core businesses are in strategic landbank management, residential development, retail shopping centers, corporate businesses, and hotels & resorts. Support businesses are in construction and property management. ALI also derives other income from its investment activities and sale of non-core assets. On April 2015, ALI bought a minority stake in Malaysian property developer MCT Bhd. in a ₱1.9-billion (US$43-million) deal, that is raised to 66.3% as of 2024.
Cardinal electors for the 1914 conclave
The papal conclave of 1914 was convened to elect a pope, the leader of the Catholic Church, to succeed Pope Pius X following his death on 20 August 1914.

Of the 65 members of the College of Cardinals at the time of Pius X's death, 57 participated in the subsequent conclave. William Henry O'Connell and James Gibbons arrived too late from the United States, as did Louis-Nazaire Bégin from Quebec. Sebastiano Martinelli, Franziskus von Sales Bauer, Kolos Ferenc Vaszary, Giuseppe Antonio Ermenegildo Prisco, and François-Virgile Dubillard were too ill or too frail.

The cardinal electors entered the Sistine Chapel to begin the conclave on 31 August 1914. On 3 September, after ten ballots over four days, they elected Cardinal Giacomo della Chiesa, the archbishop of Bologna, who took the papal name Benedict XV.

Archdiocese of Bologna
The Archdiocese of Bologna (Latin: Archidioecesis Bononiensis; Italian: Arcidiocesi di Bologna) is a Latin Church ecclesiastical territory or archdiocese of the Catholic Church in Northern Italy. The cathedra is in the cathedral church of San Pietro, Bologna. The current archbishop is Cardinal Matteo Zuppi, who was installed in 2015.

The Archdiocese of Bologna is a metropolitan archdiocese and has three suffragan dioceses within its ecclesiastical province: the Diocese of Imola, the Diocese of Faenza-Modigliana, and the Archdiocese of Ferrara-Comacchio.