hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
WAY-100635
WAY-100635 is a piperazine drug and research chemical widely used in scientific studies. It was originally believed to act as a selective 5-HT1A receptor antagonist, but subsequent research showed that it also acts as potent full agonist at the D4 receptor. It is sometimes referred to as a silent antagonist at the former receptor. It is closely related to WAY-100135.

In light of its dopaminergic activity, conclusions drawn from studies that employ WAY-100635 as a selective 5-HT1A antagonist may need to be re-evaluated.

Dopamine receptor D4
The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5.

The structure of DRD4 has been reported in complex with the antipsychotic drug nemonapride.

As with other dopamine receptor subtypes, the  D4 receptor is activated by the neurotransmitter dopamine. It is linked to many neurological and psychiatric conditions including schizophrenia and bipolar disorder, ADHD, addictive behaviors, Parkinson's disease, and eating disorders such as anorexia nervosa.  A weak association has been drawn between DRD4 and borderline personality disorder.

It is also a target for drugs which treat schizophrenia and Parkinson's disease. The D4 receptor is considered to be D2-like in which the activated receptor inhibits the enzyme adenylate cyclase, thereby reducing the intracellular concentration of the second messenger cyclic AMP.
Kitaseta District, Gunma
Kitaseta District (北勢多郡, Kitaseta-gun) was formerly a rural district located in Gunma Prefecture, Japan. The district is now divided between the city of Numata and the village of Shōwa.

Kitaseta District was created on December 7, 1878, with the reorganization of Gunma Prefecture into districts. It included nine villages, which were formerly part of the tenryō holdings of the Tokugawa shogunate in Kōzuke Province, three villages under the control of Maebashi Domain and three villages under joint control. With the establishment of the municipalities system on April 1, 1889, the area was organized into three villages (Kuroho, Itonose, Akagine).

On April 1, 1896, the district was merged with Tone District.

Kōzuke Province
Kōzuke Province (上野国, Kōzuke no Kuni, Japanese pronunciation: [koꜜː.(d)zɯ.ke (no kɯ.ɲi)]) was a province of Japan in the area of Japan that is today Gunma Prefecture. Kōzuke bordered Echigo, Shinano, Musashi and Shimotsuke Provinces. Its abbreviated form name was Jōshū (上州, [dʑoꜜː.ɕɯː]). Under the Engishiki classification system, Kōzuke was ranked as one of the 13 "great countries" (大国) in terms of importance, and one of the 30 "far countries" (遠国) in terms of distance from the imperial capital, Kyoto.  The provincial capital is located in what is now the city of Maebashi; however, its exact location remains uncertain. The ichinomiya of the province is located in what is now the city of Tomioka.
Attic Records
Attic Records was a Canadian independent record label, founded in 1974 by Alexander Mair and Tom Williams.  The label was known for developing Canadian talent, including Anvil, Lee Aaron, Maestro Fresh Wes, The Nylons, Teenage Head, and Triumph.  The company was also active in distributing international acts not affiliated with a major label, most successfully with Jennifer Warnes, "Weird Al" Yankovic, Katrina and the Waves, and Creed.

Attic Records ceased to exist as an independent company in 1999, when it was bought by a consortium headed by Allan Gregg and merged with TMP (The Music Publisher) and Oasis Entertainment Distribution to form The Song Corporation. The Attic label briefly continued to exist as a subsidiary of The Song Corporation, but within months of its acquisition, the label name was changed to "Song Recordings".

The Song Corporation filed for bankruptcy in May 2001. Attic's Canadian catalog and masters are now owned by Unidisc Music.

The Nylons
The Nylons were an a cappella group founded in 1978 in Toronto, Ontario, Canada, best known for their covers of pop songs such as The Turtles' "Happy Together", Steam's "Na Na Hey Hey Kiss Him Goodbye", and The Tokens' "The Lion Sleeps Tonight".

The band's final lineup included Claude Morrison (tenor), Garth Mosbaugh (tenor/baritone), Gavin Hope (baritone/tenor/bass), and Tyrone Gabriel (bass/baritone). Morrison was the only original member in the final lineup. The band has reissued all their albums on CD through Unidisc Music.

The band announced their retirement in 2016, and their final tour ended in 2017.
342 (album)
342 is the second studio album by French avant-garde metal band Pin-Up Went Down, released on 28 June 2010 through Ascendance Records. It is the first album of the band which counted with the participation of Alexis Damien's brother, Nicolas Damien.

The title of the track "Vaginaal Nathrakh" is a pun on the name of British extreme metal band Anaal Nathrakh, while "Murphy in the Sky with Dæmons" may be a possible allusion to The Beatles' song "Lucy in the Sky with Diamonds". Judging by the song's lyrics, the "Murphy" mentioned in the song's title is Edward A. Murphy, famous for popularizing the concept of "Murphy's law".

Pin-Up Went Down
Pin-Up Went Down is a French experimental band. Although their music is mostly referred to as avant-garde metal, they describe themselves as "an experimental band blending art rock, metal, avant-garde, and pop." Pin-Up Went Down was formed as a one-man project by Alexis Damien in Rouen in 2006, who then added more members.
Burbank–Livingston–Griggs House
The Burbank–Livingston–Griggs House is the second-oldest house on Summit Avenue in Saint Paul, Minnesota, United States.  It was designed in Italianate style by architect Otis L. Wheelock of Chicago and built from 1862 to 1863.  The work was commissioned by James C. Burbank, a wealthy owner of the Minnesota Stage Company.  Later, four significant local architects left their mark on the landmark structure.

The building was one of the first Minnesota properties nominated to the National Register of Historic Places, in 1970.  It was listed for its state-level significance in the theme of architecture.  It was nominated for being one of Minnesota's most elaborate examples of mid-19th-century Italianate architecture.  In 1976 it was also included as a contributing property to the Historic Hill District.

Otis Leonard Wheelock
Otis Leonard Wheelock (1816 - 1893) was an architect in upstate New York and Chicago. He and his wife had two adopted children, a son Harry B. Wheelock who was an architect and a daughter.

George H. Harlow studied under him.

He was a partner of W. W. Boyington in the firm of Boyington & Wheelock. He also partnered with William Wilson Clay. George Beaumont and Minard Lefever Beers are architects who worked at his firms.
Gulf Coast Trades Center
Gulf Coast Trades Center / Raven School (GCTC) is a charter boarding school located in unincorporated Walker County, Texas, near New Waverly. The school, operated by the nonprofit agency Gulf Coast Trades Center Inc., is in proximity to Houston.

The school, located within the Sam Houston National Forest, is a center for adjudicated children, who can learn construction trades. GCTC is an alternative to being committed into the Texas Juvenile Justice Department (TJJD) (previously the Texas Youth Commission, TYC). GCTC functions as a contract facility for the state juvenile prison system.

Walker County, Texas
Walker County is a county located in the east-central section of the U.S. state of Texas. As of the 2020 census, its population was 76,400. Its county seat is Huntsville. Initially, Walker County was named for Robert J. Walker, a legislator from Mississippi, who introduced into the United States Congress the resolution to annex Texas. Walker later supported the U.S. during its Civil War and earned some enmity for it. To keep the county's name, the state renamed it for Samuel H. Walker (no relation), a Texas Ranger and soldier in the United States Army.

Walker County comprises the Huntsville micropolitan statistical area that is part of the Houston-The Woodlands-Sugar Land combined statistical area.
Saddlebrook Academies
Saddlebrook Academies, located north of Tampa, Florida, United States in the Wesley Chapel community is a complex of sports schools, Saddlebrook Tennis Academy, Saddlebrook Golf Academy, and Saddlebrook Preparatory School. The academies are a part of Saddlebrook Resort.

Luisa Stefani
Luisa Veras Stefani (born 9 August 1997) is a professional tennis player from Brazil who specializes in doubles. Stefani is the first Brazilian woman to reach the WTA top 10 in the Open era. This milestone for Brazilian tennis was hit on 1 November 2021, when she reached a career-high ranking of world No. 9 in doubles. On 20 May 2019, she reached a singles ranking of No. 431. She had an ITF combined junior ranking of No. 10, on March 2015.

Stefani won the mixed-doubles competition at the 2023 Australian Open with Rafael Matos, becoming the first all Brazilian pair to win a major title. With that, Stefani also became the second Brazilian woman to win any major title—after Maria Bueno—and the first Brazilian woman ever to win a mixed doubles title at the Australian Open. She is also one of two Brazilians to win an Olympic medal for tennis, partnering Laura Pigossi at the 2020 Tokyo Olympics to win bronze in women's doubles.
South Pacific Air Lines
South Pacific Air Lines (SPAL) was a small US international carrier that flew from Hawaii to Tahiti from 1960 to 1963, later adding American Samoa to its small network. The airline was controlled by the Dollar family. SPAL was tiny, unable to compete with jet carriers and not able to secure sufficient route authority from the Civil Aeronautics Board (CAB) (the now defunct federal agency that then tightly regulated almost all US air transport) to expand. The airline transferred its routes to Pan Am at the end of 1963 and merged into Pan Am in 1964.

See External links for a photo of a SPAL Constellation.

Robert Dollar
Robert Dollar, also known as Captain Robert Dollar (1844–1932), was a Scottish-American industrialist born in Bainsford, Falkirk, Scotland. The title "Captain" was honorary and he was called the "Grand Old Man of the Pacific". Both were bestowed after his entry into the shipping industry. Dollar became a lumber baron, shipping magnate, philanthropist; he was also a Freemason.  His biography and an extensive introduction by him is contained within the book, Men Who Are Making the West 1923.

California Governor James Rolph Jr. said at the time of his death, "Robert Dollar has done more in his lifetime to spread the American flag on the high seas than any man in this country."  He made the cover of Time magazine on 19 March 1928, with several writings concerning his business', and was given a long obituary in the 23 May 1932, issue.
16P/Brooks
16P/Brooks, also known as Brooks 2, is a periodic comet discovered by William Robert Brooks on 7 July 1889, but failed to note any motion. He was able to confirm the discovery the next morning, having seen that the comet had moved north. On 1 August 1889, the famous comet hunter Edward Emerson Barnard discovered two fragments of the comet labeled "B" and "C" located 1 and 4.5 arc minutes away. On 2 August he found another four or five, but these were no longer visible the next day. On August 4, he observed two more objects, labeled "D" and "E". "E" disappeared by the next night and "D" was gone by the next week. Around mid-month, "B" grew large and faint, finally disappearing at the beginning of September. "C" managed to survive until mid-November 1889. The apparition ended on 13 January 1891. After the discovery apparition, the comet has always been over two magnitudes fainter.

William Robert Brooks
William Robert Brooks (June 11, 1844 – May 3, 1921) was a British-born American astronomer, mainly noted as being one of the most prolific discoverers of new comets of all time, second only to Jean-Louis Pons.
Trap run
In American football, a trap run or trap play is a run consisting of a defender on the line of scrimmage (either a defensive tackle or defensive end) getting trap blocked by an offensive lineman or back from the opposite (other side of the center) side of the ball. The play is known as a "trap" because the strong side offensive lineman will "block down" on a linebacker, seemingly leaving a defensive lineman unblocked.  As the defensive lineman comes through the seemingly open gap/hole, he is "trapped" by the weak side (also known as backside) guard who blocks the defensive lineman's blindside.    Occasionally, a trap block will come from a tight end.  Trap blocks by tight ends are known as "wham" blocks.

Typically, flow will start out one way (right or left) and the back will receive the ball going away from flow where the trap is taking place.

Pulling (American football)
Pulling is when a blocking player in American football leaves his usual spot in order to pick up another assignment on the opposite side of the field, running behind the other offensive linemen, to sprint out in front of a running back and engage a defensive player beyond the initial width of the offensive line.
Heath Murray
Heath Robertson Murray (born April 19, 1973) is an American former professional baseball player.  Murray pitched in Major League Baseball for the San Diego Padres (1997 and 1999), Detroit Tigers (2001), and Cleveland Indians (2002).

He played college baseball for Michigan, and in 1993 he played collegiate summer baseball with the Harwich Mariners of the Cape Cod Baseball League.

The Padres drafted Murray in the third round of the 1994 MLB draft.

He is a pitching coach for his high school alma mater, Troy High School.

He currently runs his own insurance agency in Troy, Ohio, and is a State Farm insurance agent.

Troy, Ohio
Troy is a city in and the county seat of Miami County, Ohio, United States. The population was 26,305 at the 2020 census, making it Miami County's largest city and Ohio's 55th-largest. Troy lies along the Great Miami River about 19 miles (31 km) north of Dayton and is part of the Dayton metropolitan area.
Listed buildings in Manchester-M16
Manchester is a city in Northwest England. The M16 postcode area is to the south of the city centre, and contains the area of Whalley Range. The postcode area contains 13 listed buildings that are recorded in the National Heritage List for England. Of these, one is listed at Grade II*, the middle grade of the three grades, and the others are at Grade II, the lowest grade.

The area, which is mainly residential, was developed in the middle of the 19th century, and at this time a number of educational buildings were also established. The listed buildings consist of houses, churches, a bowling club pavilion, colleges and schools, some of which have changed their purposes since they were first established.

Whalley Range, Manchester
Whalley Range is an area of Manchester, England, 2 miles (3.2 km) south-west of the city centre. The population at the 2011 census was 15,430. Historically in Lancashire, it was one of the earliest of the city's suburbs, built by local businessman Samuel Brooks.
I Like to Recognize the Tune
"I Like to Recognize the Tune" is an American popular song written by composer Richard Rodgers and lyricist Lorenz Hart. The song was introduced by Eddie Bracken, Marcy Wescott, Mary Jane Walsh, Richard Kollmar and Hal Le Roy in the 1939 Broadway musical Too Many Girls.

Too Many Girls (musical)
Too Many Girls is a Broadway musical comedy which was adapted for a 1940 film version starring Lucille Ball. The original Broadway production is noteworthy for advancing the career of musician Desi Arnaz. The music was composed by Richard Rodgers, the lyrics by Lorenz Hart, and the book was by George Marion, Jr.
1st Annual Latin Grammy Awards
The 1st Annual Latin Grammy Awards were held in Los Angeles at the Staples Center on Wednesday, September 13, 2000. The big winners were Luis Miguel, Santana and Maná with 3 awards; Juan Luis Guerra, Shakira, Fito Páez and Emilio Estefan Jr. received 2 awards each.

Winners were chosen by voting members of the Latin Academy from a list of finalists. The inaugural ceremony was broadcast live on CBS that year and was seen in more than 100 countries across the world. The two-hour show was the first bilingual broadcast ever to air on network television during prime time.

Los Fabulosos Cadillacs
Los Fabulosos Cadillacs (Spanish pronunciation: [los faβuˈlosos ˈkaðilaks], lit. 'The Fabulous Cadillacs') is an Argentine musical group from Buenos Aires. Their music fuses ska with Latin rock and various other styles.
Vidor Independent School District
The Vidor Independent School District is a public school district  based in Vidor, Texas, United States. The district serves a 121.38-square-mile (314.4 km2) area in northwestern Orange County, including the cities of Vidor, Rose City, and Pine Forest, and a small portion of far southwestern Jasper County. The Jasper County portion has 16 square miles (41 km2) while the remainder is in Orange County.

In 2009, the school district was rated "recognized" by the Texas Education Agency.

Orange County, Texas
Orange County is a county located in the very southeastern corner of the U.S. state of Texas, sharing a boundary with Louisiana, within the Golden Triangle of Texas. As of the 2020 census, its population was 84,808. The county seat is the city of Orange, and it falls within the Beaumont–Port Arthur metropolitan area.
Big Sandy, West Virginia
Big Sandy is a  census-designated place (CDP) located in McDowell County, West Virginia, United States. As of the 2020 census, its population is 198 (up from 168 at the 2010 census). The town's name comes from the Big Sandy River, a major tributary of the Ohio River which forms the boundary between West Virginia and Kentucky.

McDowell County, West Virginia
McDowell County is a county in the State of West Virginia. As of the 2020 census, the population was 19,111, and was estimated to be 17,147 in 2024.

The county seat and the largest city is Welch. McDowell County is the southernmost county in the state. It was created in 1858 by the Virginia General Assembly and named for Virginia Governor James McDowell. It became a part of West Virginia in 1863, when several Union-affiliated counties seceded from the state of Virginia during the American Civil War. McDowell County is located in the Cumberland Mountains, part of the Appalachia region.

Due mostly to a decline in employment in the coal mining industry, McDowell County's population has decreased from almost 100,000 in 1950 to less than 20,000 in 2020. The people of McDowell County suffer high rates of drug abuse and poverty and have a life expectancy well below the national average.
Bushy Park, Tasmania
Bushy Park is a rural locality and town in the local government area of Derwent Valley in the South-east region of Tasmania. It is located about 19 kilometres (12 mi) north-west of the town of New Norfolk. The 2016 census determined a population of 126 for the state suburb of Bushy Park.

Local government areas of Tasmania
The councils of Tasmania are the 29 local administrative units of the Australian state of Tasmania. Local government areas (LGAs), more generally known as councils, are the tier of government responsible for the management of local duties such as road maintenance, town planning and waste management.
Nausea (novel)
Nausea (French: La Nausée) is a philosophical novel by the existentialist philosopher Jean-Paul Sartre, published in 1938. It is Sartre's first novel.

The novel takes place in 'Bouville' (homophone of Boue-ville, literally, 'Mud town') a town similar to Le Havre. It comprises the thoughts and subjective experiences—in a personal diary format—of Antoine Roquentin, a melancholic and socially isolated intellectual who is residing in Bouville ostensibly for the purpose of completing a biography on a historical figure. Roquentin's growing alienation and disillusionment coincide with an increasingly intense experience of revulsion, which he calls "the Nausea", in which the people and things around him seem to lose all their familiar and recognizable qualities. Sartre's original title for the novel before publication was Melancholia.

The novel has been translated into English by Lloyd Alexander as The Diary of Antoine Roquentin and by Robert Baldick as Nausea.

Bad faith (existentialism)
In existentialism, bad faith (French: mauvaise foi) is the psychological phenomenon whereby individuals act inauthentically, by yielding to the external pressures of society to adopt false values and disown their innate freedom as sentient human beings. Bad faith also derives from the related concepts of self-deception and ressentiment.
All the Young Dudes (album)
All the Young Dudes is the fifth studio album by the English rock band Mott the Hoople, released in 1972. It was their initial album for the CBS Records label (Columbia Records in the United States and Canada), after three years with Island Records in the UK and Atlantic Records in the United States and Canada.

Sweet Jane
"Sweet Jane" is a song by American rock band the Velvet Underground. Appearing on their fourth studio album Loaded (1970), the song was written by band leader and primary songwriter Lou Reed, who continued to incorporate the piece into live performances after he left the band.

When Loaded was originally released in 1970, the song's bridge was cut. The box set Peel Slowly and See (1995) and reissue Loaded: Fully Loaded Edition restored the missing section.

The song also appears on the albums Live at Max's Kansas City; 1969: The Velvet Underground Live; Peel Slowly and See; Live MCMXCIII; Loaded: Fully Loaded Edition; American Poet; Rock 'n' Roll Animal; Live: Take No Prisoners; Live in Italy; The Concert for the Rock and Roll Hall of Fame; Rock and Roll: an Introduction to The Velvet Underground; NYC Man (The Ultimate Collection 1967–2003); Live on Letterman: Music from The Late Show; and Berlin: Live At St. Ann's Warehouse.
Loimaa sub-region
Loimaa sub-region  is a subdivision of Southwest Finland and one of the sub-regions of Finland since 2009. Loimaa sub-region is one of the most agricultural regions of Southwest Finland's subregions. The region has an estimate of 37 thousand inhabitants.

Southwest Finland
Southwest Finland (Finnish: Varsinais-Suomi, IPA: [ˈʋɑrs̠inɑi̯s̠ˌs̠uo̞̯mi]; Swedish: Egentliga Finland) is a region (Finnish: maakunta, Swedish: landskap) of Finland. It borders the regions of Satakunta, Pirkanmaa, Kanta-Häme, Uusimaa, and Åland. The regional capital and most populous city is Turku, which was the capital city of Finland before Helsinki.

The region largely corresponds to the historical province of Finland Proper. Until 2019, its official English name was Finland Proper, a designation still used in Finnish (Varsinais-Suomi) and Swedish (Egentliga Finland).