hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Membrane-bound transcription factor site-2 protease
Membrane-bound transcription factor site-2 protease, also known as S2P endopeptidase or site-2 protease (S2P), is an enzyme (EC 3.4.24.85) encoded by the MBTPS2 gene which liberates the N-terminal fragment of sterol regulatory element-binding protein (SREBP) transcription factors from membranes. S2P cleaves the transmembrane domain of SREBP, making it a member of the class of intramembrane proteases.

S2P catalyses the following chemical reaction

Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP)-1, SREBP-2 and forms of the transcriptional activator ATF6.

This enzyme belongs to the peptidase family M50.

Intramembrane protease
Intramembrane proteases (IMPs), also known as intramembrane-cleaving proteases (I-CLiPs), are enzymes that have the property of cleaving transmembrane domains of integral membrane proteins. All known intramembrane proteases are themselves integral membrane proteins with multiple transmembrane domains, and they have their active sites buried within the lipid bilayer of cellular membranes. Intramembrane proteases are responsible for proteolytic cleavage in the cell signaling process known as regulated intramembrane proteolysis (RIP).

Intramembrane proteases are not evolutionarily related to classical soluble proteases, having evolved their catalytic sites by convergent evolution.

Although only recently discovered, intramembrane proteases are of significant research interest because of their major biological functions and their relevance to human disease.
North Adams Museum of History and Science
The North Adams Museum of History and Science was established by the North Adams Historical Society in 1988 to display their collections. The museum was originally located on State Street in North Adams, Massachusetts as part of the historic Western Gateway Heritage State Park. The State Street location closed in 2018. The museum then moved to the first floor of the Holiday Inn in North Adams, but had to move from that space in January, 2022. The collections are currently in storage. Some items are on display at the City Hall and a commercial location.

North Adams, Massachusetts
North Adams is a city in Berkshire County, Massachusetts, United States. It is part of the Pittsfield, Massachusetts Metropolitan Statistical Area. Its population was 12,961 as of the 2020 census. Best known as the home of the largest contemporary art museum in the United States, the Massachusetts Museum of Contemporary Art, North Adams has in recent years become a center for tourism, culture and recreation.
Balaclava, Grey County, Ontario
Balaclava is a community in the municipality of Meaford in Grey County, Ontario, Canada. It is about 17 kilometres (11 mi) northwest of the centre of Meaford and 18 kilometres (11 mi) northeast of the city of Owen Sound, about 2.5 kilometres (1.6 mi) inland of Owen Sound on Georgian Bay, Lake Huron.

Settled in the early 1850s by Scottish immigrants, Balaclava grew around a mill established by George Scott. The majority of settlers came as a result of the Highland Clearances and/or the Potato Famine (1846-1857). Balaclava was originally located at Lot 3, Concession B, and Lot 4, Concession C of Sydenham Township in Grey County (see External Links). Gradually the village moved a mile and a quarter south to its present location at the junction of County Grey Road 20 and Side Road 8. Its name is likely derived from the Crimean War (1853-1856) and the Battle of Balaclava, which occurred on October 25, 1854, and in which many Scottish soldiers died.

Meaford, Ontario
Meaford is a municipality in Grey County, Ontario, Canada located on Nottawasaga Bay, a sub-basin of Georgian Bay and Owen Sound Bay.  The municipality's seal and motto reflect its heritage as a place of apple orchards, but in the 21st century the area has partly switched to weekend homes, seasonal homes, and lakeside tourism.

The Canadian Army maintains a training facility, the 4th Canadian Division Training Centre Meaford (4 CDTC), 5 kilometres (3.1 mi) northwest of the town of Meaford.
Bells Are Ringing (musical)
Bells Are Ringing is a musical with a book and lyrics by Betty Comden and Adolph Green and music by Jule Styne. The story revolves around Ella, who works at an answering service, and the characters that she meets there. The main character was based on Mary Printz, who worked for Green's answering service. Three of the show's tunes, "Long Before I Knew You", "Just in Time", and "The Party's Over", became standards.

Judy Holliday reprised her Broadway starring role in the 1960 film of the same name, also starring Dean Martin.

Just in Time (song)
"Just in Time" is a popular song with the melody written by Jule Styne and the lyrics by Betty Comden and Adolph Green. It was introduced by Judy Holliday and Sydney Chaplin in the musical Bells Are Ringing in 1956. Judy Holliday and Dean Martin sang the song in the 1960 film of Bells Are Ringing. Martin then recorded it for his 1960 album, This Time I'm Swingin'!. Tony Bennett recorded the song in 1956 and continued performing it until his retirement, at Radio City Music Hall, in 2021 at the age of 95.
Kill After Kill
Kill After Kill is the sixth studio album by the Canadian speed metal band Exciter, released in 1992. It was the last album to feature founding member, singer/drummer Dan Beehler, only album with bassist David Ledden, and the first to feature guitarist John Ricci since 1985's Long Live the Loud.

Exciter (band)
Exciter is a Canadian speed metal band from Ottawa, Ontario, formed in 1978. Named after a song by Judas Priest, they are considered to be one of the first speed metal bands and cited as a seminal influence on the thrash metal genre. Despite many changes in personnel, limited commercial success, and two disbandments (first in 1989 and again in 1993), Exciter has managed to keep a small but dedicated following over the years.
Shadrach (novel)
Shadrach  is a 1954 children's novel by Dutch American author Meindert De Jong and illustrated by Maurice Sendak, the first of seven books that Sendak illustrated for De Jong.  The book was one of two Meindert books that earned a Newbery Honor in 1954; the other was Hurry Home, Candy.

Maurice Sendak
Maurice Bernard Sendak (/ˈsɛndæk/; June 10, 1928 – May 8, 2012) was an American author and illustrator of children's books. Born to Polish-Jewish parents, his childhood was impacted by the death of many of his family members during the Holocaust. Sendak illustrated his own books as well as those by other authors, such as the Little Bear series by Else Holmelund Minarik. He achieved acclaim with Where the Wild Things Are (1963), the first of a trilogy followed by In the Night Kitchen (1970) and Outside Over There (1981). He also designed sets for operas, notably Mozart's The Magic Flute.

In 1987, Sendak was the subject of an American Masters documentary, "Mon Cher Papa". In 1996, he received the National Medal of Arts. Per Margalit Fox, Sendak, "the most important children's book artist of the 20th century", "wrenched the picture book out of the safe, sanitized world of the nursery and plunged it into the dark, terrifying and hauntingly beautiful recesses of the human psyche."
Paul Kupperberg
Paul Kupperberg (/ˈkʌpərbɜːrɡ/; born June 14, 1955) is an American writer and comics editor. He is currently a writer and executive editor at Charlton Neo Comics and Pix-C Webcomics, and a contributing author with Crazy 8 Press. Formerly, he was an editor for DC Comics and executive editor of Weekly World News, as well as a writer of novels, comic books, and newspaper strips.

Warlord (DC Comics)
The Warlord is a sword and sorcery character appearing in American comic books published by DC Comics. Created by writer-artist Mike Grell, he debuted in 1st Issue Special #8 (November 1975). The titular character, Travis Morgan, obtains the name "Warlord" as he fights for the freedom of the people of Skartaris.
Norman Munro
Norman Leslie Munro (1842–1894) was a Canadian-American publisher.

In 1873 Munro established the New York Family Story Paper, which gained a weekly circulation of 325,000. He also published Boys of New York, Our Boys, Munro's Library, and the American juvenile magazine Golden Hours in the late 19th century. One of his main writers was H. Irving Hancock.  He also published Nellie Bly's 1887 investigative journalism exposé Ten Days in a Mad-House.

Throughout his life, Munro owned several fast steam yachts including the Herreshoff-designed Norwood, which garnered extensive media attention for its competition with William Randolph Hearst's rival yacht Vamoose to set speed new records. In 1887 Nathanael Greene Herreshoff designed the steam yacht Now Then for Munro.

Munro died on February 24, 1894, in New York City after an appendectomy and was survived by his wife and two children.  He is buried in Green-Wood Cemetery.

Nellie Bly
Elizabeth Cochrane Seaman (born Elizabeth Jane Cochran; May 5, 1864 – January 27, 1922), better known by her pen name Nellie Bly, was an American journalist who was widely known for her record-breaking trip around the world in 72 days in emulation of Jules Verne's fictional character Phileas Fogg, and for an exposé in which she worked undercover to report on a mental institution from within. She  ushered in the era of stunt girl reporting and helped advance a new kind of immersion journalism.
Naguilian Road
The Naguilian Road, officially the Quirino Highway and also known as the Baguio–Bauang Road, is a Philippine major highway in northern Luzon that runs from the city of Baguio in the province of Benguet to the municipality of Bauang in the province of La Union.

The 39.114-kilometer (24.304 mi) highway traverses the Benguet municipalities of Tuba and Sablan, and the La Union towns of Burgos, Naguilian, and Bauang.

The highway serves as a major access route to Baguio. It is primarily used by motorists coming from the port city of San Fernando as well as the northern provinces of the Ilocos Region to get to the city.

Although Quirino Highway is the official name of the road, most people are more used to calling it by its former name. It is also a component of National Route 54 (N54) of the Philippine highway network, where Kennon Road also belongs.

Burgos, La Union
Burgos, officially the Municipality of Burgos (Ilocano: Ili ti Burgos; Filipino: Bayan ng Burgos), is a municipality in La Union, Philippines, named after the Filipino martyr Father Jose Burgos. According to the 2024 census, it has a population of 9,121 people making it the least populated municipality in the province.

The town is known for its production of colored soft brooms made from tiger grass.
Visita de San Juan Bautista Londó
The Visita de San Juan Bautista Londó was a Catholic visita located at the Cochimí settlement of Londó in what is now Loreto Municipality, Baja California Sur, Mexico. The visita was founded by Jesuit missionaries Juan María Salvatierra and Francisco María Piccolo in 1699 as an extension of Misión de Nuestra Señora de Loreto Conchó.

Visitas
Visitas or asistencias were smaller sub-missions of Catholic missions established during the 16th-19th centuries of the Spanish colonization of the Americas and the Philippines. They allowed the Catholic church and the Spanish crown to extend their reach into native populations at a modest cost.
West Coast National Park
The West Coast National Park lies 88 km (55 mi) north of Cape Town in the Western Cape province of South Africa. The park is found inside of the Cape West Coast Biosphere Reserve, part of the UNESCO Man and the Biosphere Programme. It is bordered by the Atlantic Ocean on the west and the R27 coastal road, and runs from the town of Yzerfontein in the south, up to the Langebaan Lagoon. The park is particularly well known for its bird life and for the spring flowers which occur in the months from August to September, especially in the Postberg flower reserve section of the park. The park, with the islands in Saldanha Bay, has been identified by BirdLife International as an Important Bird Area. The park was proclaimed in 1985, and is 36,259.8 hectares (140.000 sq mi) in size.

Saldanha Bay
Saldanha Bay (Afrikaans: Saldanhabaai) is a natural harbour on the south-western coast of South Africa. The town that developed on the northern shore of the bay, also called Saldanha, was incorporated with five other towns into the Saldanha Bay Local Municipality in 2000. The current population of the municipality is estimated at 72,000.

The place is mentioned in the first edition of John Locke's Two Treatises of Government as an example of the state of nature.

Saldanha Bay's location makes it a paradise for the watersport enthusiast, and its local economy being strongly dependent on fishing, mussels, seafood processing, the steel industry and the harbour. Furthermore, its sheltered harbour plays an important part in the Sishen-Saldanha iron-ore project (connected by the Sishen-Saldanha Railway Line) at which Saldanha Steel takes center stage.
Juzzthin
Muhammad Nazreen bin Norzali (Jawi: محمد نازرين نورزالي, born 2 August 1990), known professionally as Juzzthin, is a Malaysian rapper and actor. He is known for his television debut for his role as Syed in Disney's Waktu Rehat.

Waktu Rehat
Waktu Rehat (English: Break Time), also known as As the Bell Rings Malaysia, is a Disney Channel Asia original television series based on the Disney Channel Italy series Quelli dell'intervallo. The series follows a group of Malaysian lower secondary school students at the fictional S.M. Jalan Mas (Golden Road Secondary School) in the school hallway during recess.

The series premiered on 31 August 2010, and ran for three seasons until 30 September 2012. The first episode, titled "Durian Breath" or "Nafas Durian", was shown online on 18 August 2010 on Disney Channel Asia's website and YouTube channel. The series aired every Saturday and Sunday at 11:50 MST, with English subtitles added in each episode. All three seasons of the series were released to Disney+ Hotstar in 2021.
Adenomera lutzi
Adenomera lutzi is a species of frog in the family Leptodactylidae. The species is endemic to Guyana. First described from the upper Potaro River based on specimens collected before 1905, it is now known from a number of sites around the Pakaraima Mountains in west-central Guyana. The specific name lutzi honors Adolfo Lutz, a Brazilian medical entomologist and parasitologist: 129–130  and a pioneer of herpetology. The common names Lutz's tropical bullfrog and Lutz's thin-toed frog have been coined for the species.

Adolfo Lutz
Adolfo Lutz (18 December 1855 – 6 October 1940) was a Brazilian physician, father of tropical medicine and medical zoology in Brazil, and a pioneer epidemiologist and researcher in infectious diseases.
Anne Pedersdotter (play)
Anne Pedersdotter (English version, The Witch, trans. John Masefield) is a play written in 1908 by Norwegian playwright Hans Wiers-Jenssen. The play is based on an incident from 1590, when Anne Pedersdotter, the widow of priest Absalon Pederssøn Beyer, was accused of witchcraft and burned alive in the city of Bergen.

Hans Wiers-Jenssen
Hans Wiers-Jenssen (25 November 1866 – 25 August 1925)  was a Norwegian novelist, playwright, stage producer and theatre historian. Wiers-Jenssen was employed at the theatres Christiania Theatre, Nationaltheatret and Den Nationale Scene.
Afterwards (play)
Afterwards is a 1933 mystery play by the British-American writer Walter Hackett revolving around a psychic medium.

It enjoyed a West End run of 208 performances at the Whitehall Theatre between 7 November 1933 and 12 June 1934. The original London cast included Gordon Harker, Henry Daniell, Ronald Shiner, Jeanne Stuart and Marion Lorne.

Marion Lorne
Marion Lorne MacDougal or MacDougall (August 12, 1883 – May 9, 1968), known professionally as Marion Lorne, was an American actress on stage, film, and television. After a career in theatre in New York and London, Lorne made her first film in 1951, and for the remainder of her life played small roles in films and television. Her recurring role as Aunt Clara in the comedy series Bewitched, between 1964 and her death in 1968, brought her widespread recognition, and she was posthumously awarded an Emmy Award for Outstanding Supporting Actress in a Comedy Series.
Ronald Cove-Smith
Ronald Cove-Smith (26 November 1899 – 9 March 1988) was a physician and sportsman. He represented Old Merchant Taylors and King's College Hospital RFC. Internationally he represented the England national rugby union team in 29 tests (1921–1929) (seven as captain) and also captained the British Isles in four tests on the 1924 British Lions tour to South Africa as a lock. He finished on the winning side in 22 of his 29 England matches. He was commissioned in the Grenadier Guards in 1918–1919. In addition to rugby he excelled at swimming and water-polo, winning half-blues in each.

King's College Hospital RFC
King's College Hospital RFC is an open rugby union club founded in the 19th century as a football club whose representatives were made up of medics from King's College Hospital. In its original form it was one of the twenty-one founding members of the Rugby Football Union, and produced a number of international players in the sport's early international fixtures. The merging of King's College Hospital medical department in 1999 with the already merged Guy's Hospital and St Thomas' Hospital led to the creation of Guy's, Kings and St. Thomas' Rugby Football Club, an amalgam of three formerly distinct hospital rugby clubs each with a long history. King's College Hospital Rugby Football Club opted to remain a separate entity in so doing became an open rugby club that no longer represented the Hospital medics.
Professor T. (German TV series)
Professor T. is a German TV crime-drama series set in Cologne about an eccentric professor at Cologne University, Jasper Thalheim, who is an advisor to the police. It is an adaptation from the Belgian TV series of the same name which has also a remake by the same name in France. There are four seasons with four episodes each, after which the series concluded. All episodes were aired on the German broadcasting channel ZDF.

Professor T. (Belgian TV series)
Professor T. is a Belgian TV drama series set in Antwerp about an eccentric professor at the University of Antwerp. Professor Jasper Teerlinck, a.k.a. Professor T, is a professor of criminology. Annelies Donckers, a former student of his who has become an inspector of the Federal Judicial Police, regularly summons the help of her former professor as a consultant. The show lasted for three seasons, released in 2015, 2016 and 2018. The producers, Skyline Entertainment, announced that the third season would be its last.
Singapore Badminton Association
Singapore Badminton Association (abbreviation: SBA) is the national governing body for badminton in Singapore.  It governs, encourages and develops the sport throughout the country.

Founded in 1929, the SBA is an affiliate of the Singapore National Olympic Council (SNOC). It is also a member of the Badminton World Federation (BWF) and Badminton Asia, which was formerly known as the Badminton Asian Confederation.

As of 2022, the SBA has a total of 33 member clubs across the country. It closely liaises with the member clubs to provide support to the club and league structures.

Loh Kean Yew
Loh Kean Yew (born 26 June 1997) is a Singaporean badminton player. He is the former men's singles world champion, winning the title at the 2021 BWF World Championships, becoming the first Singaporean to achieve this feat. He is known for his agility, footwork and powerful smashes.

Loh's success as a child in Penang state team saw him receive a scholarship from the Singapore Sports School. He made his international debut for Singapore at the 2015 SEA Games, becoming a Singaporean citizen that same year. He went on to represent Singapore in several international competitions, including the 2020 Tokyo Olympics.
Chidimma Adetshina
Chidimma Vanessa Onwe Adetshina Listenⓘ (born 8 January 2001) is a Nigeria beauty pageant titleholder who won Miss Universe Nigeria 2024. She represented Nigeria at the Miss Universe 2024 pageant in Mexico and finished as the first runner-up. She was also crowned Miss Universe Africa and Oceania as the highest ranked African Contestant of 2024. Her placement is Nigeria's highest at any Miss Universe pageant.

Miss Universe 2024
Miss Universe 2024 was the 73rd Miss Universe pageant, held at the Arena CDMX in Mexico City, Mexico, on 16 November 2024.

Sheynnis Palacios of Nicaragua crowned Victoria Theilvig of Denmark as her successor at the conclusion of the event. This was Denmark's first win in the pageant's history.

Contestants from a record 125 countries and territories competed in the pageant, surpassing the previous record of 94 entrants set in 2018.
Prostration
Prostration is the gesture of placing one's body in a reverentially or submissively prone position. Typically prostration is distinguished from the lesser acts of bowing or kneeling by involving a part of the body above the knee, especially the hands, touching the ground.

Major world religions employ prostration as an act of submissiveness or worship to an entity or to the Supreme Being (i.e. God), as in the metanoia in Christian prayer used in the Eastern Orthodox and Oriental Orthodox Churches, and in the sujud of the Islamic prayer, salat. In various cultures and traditions, prostrations are similarly used to show respect to rulers, civil authorities and social elders or superiors, as in the Yoruba Idobale, Chinese kowtow or Ancient Greek proskynesis.  The act has often traditionally been an important part of religious, civil and traditional rituals and ceremonies, and remains in use in many cultures.

Metanoia (theology)
In Christian theology, the term metanoia (from the Greek μετάνοια, metanoia, changing one's mind) is often translated as "conversion" or "repentance," though most scholars agree that this second translation does a disservice to the original Greek meaning of metanoia.

In Christianity, especially in Orthodox Christianity, the Greek philosophical concept of metanoia has become linked with Christian prayer, in which a prostration is called a metanoia, with "the spiritual condition of one's soul being expressed through the physical movement of falling facedown before the Lord" as seen in the biblical passages of Matthew 2:11, Luke 5:12, and Luke 17:15–16. In this context, the term suggests repudiation, change of mind, repentance, and atonement.