hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
(R)-69
(R)-69 (3IQ) is a drug of the tetrahydropyridinylpyrrolopyridine family related to the psychedelic tryptamines which acts as a 5-HT2A receptor agonist, with 4.6-fold selectivity over 5-HT2B and 49-fold selectivity over 5-HT2C. It has a 5-HT2A Ki of 680 nM and an EC50 of 41 nM. (R)-69 is a biased agonist selective for activation of the Gq coupled signalling pathway, with much weaker activation of the β-arrestin 2 coupled pathway. In animal studies it produces antidepressant-like activity but without producing the head-twitch response associated with psychedelic effects. The drug was identified along with its close analogue (R)-70 via an ultra-large-scale docking campaign against the serotonin 5-HT2A receptor and was first described by Bryan L. Roth and colleagues in 2022. A number of related derivatives have also been developed.

5-HT2A receptor
The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and functions as a G protein-coupled receptor (GPCR). It is a cell surface receptor that activates multiple intracellular signalling cascades.
Like all 5-HT2 receptors, the 5-HT2A receptor is coupled to the Gq/G11 signaling pathway. It is the primary excitatory receptor subtype among the serotonin-responsive GPCRs. The 5-HT2A receptor was initially noted for its central role as the primary target of serotonergic psychedelic drugs such as LSD and psilocybin mushrooms. It later regained research prominence when found to mediate, at least in part, the effects of many antipsychotic drugs, particularly atypical antipsychotics.
Calling (Flow song)
CALLING is FLOW's nineteenth single. Its A-Side was used as the first ending theme song for Heroman. The single has two editions: regular and limited. The limited edition includes a bonus DVD with extra clips including its music video. It reached #21 on the Oricon charts and charted for 3 weeks. *

Flow (Japanese band)
Flow (stylized in all caps) is a Japanese rock band formed in 1998 as a five-piece band made up of two vocalists, a guitarist, a bassist, and a drummer. They are signed to Sacra Music. As of November 2023, the band has released 40 singles and 12 studio albums. Their songs have been featured in the opening sequences of several anime and Japanese drama series.
Maurice Gaudefroy-Demombynes
Maurice Gaudefroy-Demombynes (15 December 1862 – 12 August 1957) was a French Arabist, a specialist in Islam and the history of religions.

His best known works are his historical and religious studies on Hajj and Muslim institutions. He also translated into French in an annotated edition the story of Arab travel writer and explorer Ibn Jubair (1145–1217). His book written after Arab authors on Syria at the time of the Mamluk is also a seminal work.

Maurice Gaudefroy-Demombynes was a professor at the École nationale des langues orientales vivantes (today INALCO).

Ibn Jubayr
Ibn Jubayr (1 September 1145 – 29 November 1217; Arabic: ابن جبير), also written Ibn Jubair, Ibn Jobair, and Ibn Djubayr, was an Arab geographer, traveller and poet from al-Andalus.  His travel chronicle describes the pilgrimage he made to Mecca from 1183 to 1185, in the years preceding the Third Crusade.  His chronicle describes Saladin's domains in Egypt and the Levant which he passed through on his way to Mecca. Further, on his return journey, he passed through Christian Sicily, which had been recaptured from the Muslims only a century before, and he made several observations on the hybrid polyglot culture that flourished there.
Toolesboro, Iowa
Toolesboro is an unincorporated community in southeastern Louisa County, Iowa, United States.

The community is on Iowa Route X99 approximately seven miles southeast of Wapello and the Iowa River passes just to the east.

Louisa County, Iowa
Louisa County (/luˈaɪzə/ loo-EYE-zə) is a county located in the U.S. state of Iowa. As of the 2020 census, the population was 10,837. The county seat and the largest city is Wapello.

Louisa County is part of the Muscatine Micropolitan Statistical Area.
Kremmling, Colorado
The Town of Kremmling is a Statutory Town in Grand County, Colorado, United States. The town population was 1,509 at the 2020 United States census.  The town sits along the upper Colorado River in the lower arid section of Middle Park between Byers Canyon and Gore Canyon. The town was founded in 1881 during the Colorado Silver Boom days, but the lack of mineral resources in the nearby mountains made the town grow very slowly in the early days.

Middle Park (Colorado basin)
Middle Park (elev. 8,000 ft or 2,400 m) is a high basin in the western United States, in the Rocky Mountains of north-central Colorado. Located in Grand County, it is on the southwest slope of Rocky Mountain National Park, approximately fifty miles (80 km) west of Boulder, on opposite sides of the continental divide.
La Guirlande de Campra
La Guirlande de Campra is collaborative orchestral work written by seven French composers in 1952. It is in the form of variations or meditations on a theme from André Campra's 1717 opera Camille, reine des Volsques.

The numbers and their composers are:

Toccata (Arthur Honegger*)

Sarabande et farandole (Daniel Lesur)

Canarie (Alexis Roland-Manuel)

Sarabande (Germaine Tailleferre*)

Matelote provençale (Francis Poulenc*)

Variation (Henri Sauguet)

Écossaise (Georges Auric*)

*Member of the group Les Six

The work was first performed on 30 July 1952 at the Aix-en-Provence Festival, by the Orchestre de la Société des Concerts du Conservatoire, under conductor Hans Rosbaud.

Benjamin Britten attended the premiere, and it gave him the idea of commissioning several composers to contribute to a set of Variations on an Elizabethan Theme to celebrate the forthcoming coronation of Elizabeth II, for which he was also writing his opera Gloriana.

André Campra
André Campra (French: [kɑ̃pʁa]; baptized 4 December 1660 – 29 June 1744) was a French composer and conductor of the Baroque era. The leading French opera composer in the period between Jean-Baptiste Lully and Jean-Philippe Rameau, Campra wrote several tragédies en musique and opéra-ballets that were extremely well received. He also wrote three books of cantatas as well as religious music, including a requiem.
Mazda MX-3
The Mazda MX-3 is a 2+2-seat, front-wheel drive coupé of a kammback design, manufactured and marketed by Mazda. It was introduced at the Geneva Auto Show in March 1991 and marketed until 1998.

The MX-3 was also marketed as the Mazda MX-3 Precidia in Canada and as the Eunos Presso, Autozam AZ-3 and Mazda AZ-3 in Japan. In Australia it was marketed as the Eunos 30X until late 1996 when it became the Mazda-Eunos 30X.

Kammback
A Kammback, also known as a Kamm tail or K-tail, is an automotive styling feature wherein the rear of the car slopes downwards before being abruptly cut off with a vertical or near-vertical surface. A Kammback reduces aerodynamic drag, thus improving efficiency and reducing fuel consumption, while maintaining a practical shape for a vehicle.

The Kammback is named after German aerodynamicist Wunibald Kamm for his work developing the design in the 1930s.

Some vehicles incorporate the kammback design based on aerodynamic principles, while some use a cut-off tail as a design or marketing feature.
And This Is Our Music
...And This Is Our Music is the ninth studio album by The Brian Jonestown Massacre, released on October 7, 2003, on Tee Pee Records. It was re-released on A Records, packaged alongside the "If Love Is the Drug, Then I Want to O.D" single, and was distributed in the UK through Cargo Records.

The Brian Jonestown Massacre
The Brian Jonestown Massacre is an American rock band founded and led by Anton Newcombe. It was formed in San Francisco in 1990 and has featured a revolving cast of members since forming.

Initially influenced by Shoegaze and Dream Pop on their first two albums, the band would eventually shift towards a sound influenced by 1960s Psychedelic rock and Garage rock on their third album, Take It from the Man!. The collective has released 20 studio albums, six compilation albums, five live albums, 14 EPs and 24 singles, as well as two various-artist compilation albums to date.

The group has gained media notoriety for their tumultuous working relationships as well as the erratic behavior of Newcombe. The group received further notoriety when they were the subject of the 2004 documentary film called Dig!.
Art of This Century gallery
The Art of This Century gallery was opened by Peggy Guggenheim at 30 West 57th Street in Manhattan, New York City on October 20, 1942. The gallery occupied two commercial spaces on the seventh floor of a building that was part of the midtown arts district including the Museum of Modern Art, the Museum of Non-Objective Painting, Helena Rubinstein's New Art Center, and numerous commercial galleries. The gallery exhibited important modern art until it closed in 1947, when Guggenheim returned to Europe. The gallery was designed by architect, artist, and visionary Frederick Kiesler.

Marcel Duchamp
Henri-Robert-Marcel Duchamp (UK: /ˈdjuːʃɒ̃/, US: /djuːˈʃɒ̃, djuːˈʃɑːmp/; French: [maʁsɛl dyʃɑ̃]; 28 July 1887 – 2 October 1968) was a French American artist, chess player, and inventor who played a key role in the development of the avant-garde in the United States and in New York City, where he spent the last 25 years of his life.

Duchamp was the first artist to elevate a toilet to the status of an art form. By the time of World War I, he had rejected the work of many of his fellow artists (such as Henri Matisse) as "retinal," intended only to please the eye. Instead, he wanted to use art to serve the mind. He is commonly regarded, along with Pablo Picasso and Georges Braque, as one of the three artists who helped to establish the post-industrial perspective in art history, and  his work is considered the progenitor of Conceptual art.
Dziebędów
Dziebędów [d͡ʑɛˈbɛnduf] is a village in the administrative district of Gmina Wróblew, within Sieradz County, Łódź Voivodeship, in central Poland. It lies approximately 7 km (4 mi) north-west of Wróblew, 16 km (10 mi) west of Sieradz, and 67 km (42 mi) west of the regional capital Łódź.

Gmina Wróblew
Gmina Wróblew is a rural gmina (administrative district) in Sieradz County, Łódź Voivodeship, in central Poland. Its seat is the village of Wróblew, which lies approximately 10 kilometres (6 mi) west of Sieradz and 62 km (39 mi) west of the regional capital Łódź.

The gmina covers an area of 113.23 square kilometres (43.7 sq mi), and as of 2006 its total population is 6,244.
Torch River (Michigan)
The Torch River is a short river in the Northern Lower Peninsula of the U.S. state of Michigan. At 2.1 miles (3.4 km) in length, the river connects Torch Lake to Lake Skegemog, and is a crucial link in the Elk River Chain of Lakes Watershed. The river is divided along its entire length between Antrim and Kalkaska counties. The northern source of the river is home to a Michigan Department of Natural Resources (DNR) Access Site.

The Rapid River is a major tributary of the Torch River.

Lake Skegemog
Lake Skegemog (/ˈskiːɡəmɔːɡ/ SKEE-guh-mawg), formerly known as Round Lake and Skegemog Lake, is a lake in Northern Michigan. The lake is part of the Elk River Chain of Lakes, itself part of the Lake Michigan watershed. Within the lake is the tripoint of Antrim, Grand Traverse, and Kalkaska counties.
Mary Richardson Walker
Mary Richardson Walker (April 1, 1811 –  December 5, 1897) was an American missionary. She was the daughter of Joseph and Charlotte Richardson of West Baldwin, Maine. Both parents were school teachers and valued education for all their children. She attended Maine Wesleyan Seminary. Mary wanted to be a missionary and applied at the American Board of Missionaries, but she was turned down, because she was not married.

William Thayer, a mutual friend of Mary Richardson and Elkanah Walker, knew they wanted to be missionaries, so he set up a meeting between them. After a 48-hour courtship, Elkanah proposed to Mary. A year later on March 5, 1838, they married hurriedly so they could depart for the Oregon Country as missionaries.

Cushing Eells
Cushing Eells (February 16, 1810 – February 16, 1893) was an American Congregational church missionary, farmer and teacher on the Pacific coast of America in what are now the states of Oregon and Washington. His first mission in Washington State was unsuccessful. Eells and his family had to leave after the Native Americans massacred a group of neighboring missionaries.
They spent the next fourteen years farming and teaching in Oregon, before returning to Washington, where Eells founded a seminary that later became Whitman College.
Eells continued to teach and preach in Washington for the remainder of his life.
Ethel (film)
Ethel is a 2012 documentary that premiered at the Sundance Film Festival. The subject of the documentary is Ethel Kennedy, the widow of Robert F. Kennedy. Ethel was scheduled to premiere on HBO later in 2012.

Rory Kennedy, the youngest of their 11 children, asked her mother Ethel if she would be a part of a documentary. Opening with Ethel's memories about her family, the documentary has five days worth of interviews including Ethel's children. The Kennedy family is documented in home videos and pictures.

Rory called her mother's life one of the great untold stories.

The documentary is scored by Miriam Cutler.

Ethel Kennedy
Ethel Kennedy (née Skakel /ˈskeɪkəl/ SKAY-kəl; April 11, 1928 – October 10, 2024) was an American human rights advocate. She was the widow of U.S. Senator Robert F. Kennedy, a sister-in-law of U.S. president John F. Kennedy, and a daughter of businessman George Skakel.
John Chisholm (archbishop of Melanesia)
John Wallace Chisholm, (14 September 1923 – 24 May 1975) was an Australian divine who served as the tenth Anglican Bishop of Melanesia and first Archbishop of the Province of Melanesia.

He was educated at Trinity College, University of Melbourne and ordained in 1947. His first post was as a Curate at St Stephen's Church, Rochester Row, Westminster after which he was Sub-Dean of Ss Peter and Paul Cathedral, Dogura, Territory of Papua and New Guinea. From his consecration as a bishop on 24 February 1964 until 1967 he was an Auxiliary Bishop of the Diocese of New Guinea when he became Bishop of Melanesia, a post he held until 26 January 1975 aged 51, when the Diocese of Melanesia became a province and he automatically became Archbishop of Melanesia (and Primate) and Bishop of Central Melanesia. He died on 24 May, shortly after signing the last paperwork of the Province's creation process.

Anglican Church of Papua New Guinea
The Anglican Church of Papua New Guinea is a province of the Anglican Communion. It was created in 1977 when the Province of Papua New Guinea became independent from the Province of Queensland in the Church of England in Australia (officially renamed the Anglican Church of Australia in 1981) following Papua New Guinea's independence in 1975.
God Sound
God Sound is the second album by the American rap group Boogiemonsters, released in 1997. It was produced by the group and Domingo. It was Boogiemonsters' final album.

The album peaked at No. 47 on the Top R&B/Hip-Hop Albums chart and No. 15 on the Top Heatseekers chart. A single, "Beginning of the End", reached No. 89 on the Hot R&B Singles chart and No. 39 on the Hot Rap Singles chart.

Boogiemonsters
Boogiemonsters were an American hip hop group composed by  Bronx, New York rapper Mondo McCann, Alaskan-born Vex Da Vortex (Sean Pollard) and Jamaican-born brothers Myntric (Sean Myers) and Yodared (Ivor "Al" Myers).
Schema Records
Schema Records is a prominent Italian record label in Milan, Italy, that specializes in jazz, Brazilian, and Latin-influenced music. Schema is a sublabel of Ishtar, a recording and publishing company based in Milan, which runs the sublabels Schema Rearward, Sensible, Summer Dawn, Big Sur Recordings and Milano 2000.

Schema was founded in 1997 by Luciano Cantone and Davide Rosa. Their catalogue includes music by Alessandro Magnanini, Balanco, Benny Bailey, Eraldo Volonté, Gerardo Frisina, Giorgio Azzolini, Johnny Griffin, Kenny Clarke/Francy Boland Big Band, Les Hommes, Mario Biondi, Neos, Nicola Conte, Piero Umiliani, Pietro Ciancaglini, Quartetto di Lucca, Rosalia de Souza, Sahib Shibab, Soulstance, Steve Evans, Marvin Parks, and Toco.

Rosalia de Souza
Rosalia de Souza (born July 4, 1966) is a Brazilian bossa nova singer. She was born in Nilópolis, Rio de Janeiro, Brazil, an area famous for its samba school, Beija-Flor.

After travelling to Italy at the age of 21, she began to study music theory, Cuban percussion, and jazz at the Scuola Popolare di Testaccio (Popular school of Testaccio) in Rome.
Attempted assassination of Vassos Lyssarides
On August 30, 1974, an attempted assassination of Vassos Lyssarides, prominent supporter of Makarios III, failed to kill Lyssarides, but killed EDEK youth leader Doros Loizou and injured three others.

Loizou drove the car Lyssarides and Barbara Bell were riding in, and, after being shot at, immediately accelerated, saving the lives of the passengers. He himself died.

Time magazine said Lyssarides was slightly wounded, his wife badly hit, and that Loizou and a bystander were killed. It claimed that Greek Cypriot extremists were the suspected assassins.

According to the Financial Mirror, "It is believed the assassins were remnants of the EOKA B underground movement".

Doros Loizou
Doros Loizou (Δώρος Λοΐζου) (February 23, 1944—August 30, 1974) was a Cypriot poet and leader of the youth section of EDEK (the Movement for Social Democracy). He was killed in the attempted assassination of Vassos Lyssarides.

Mimi Sofokleous , a poet presented his book titled “The Poet Doros Loizou (1944-1974)” in Strovolos in honour of Doros and the book is published by Afī Editions.
Beckwith–Wiedemann syndrome
Beckwith–Wiedemann syndrome (/ˈbɛkˌwɪθ ˈviːdə.mən/; abbreviated BWS) is an overgrowth disorder usually present at birth, characterized by an increased risk of childhood cancer and certain congenital features. A minority (<15%) of cases of BWS are familial, meaning that a close relative may also have BWS, and parents of an affected child may be at increased risk of having other children with BWS. While children with BWS are at increased risk of childhood cancer, most children with BWS do not develop cancer and the vast majority of children who do develop cancer can be treated successfully.

Hepatoblastoma
Hepatoblastoma is a malignant liver cancer occurring in infants and children and composed of tissue resembling fetal liver cells, mature liver cells, or bile duct cells. They usually present with an abdominal mass.  The disease is most commonly diagnosed during a child's first three years of life. Alpha-fetoprotein (AFP) levels are commonly elevated, but when AFP is not elevated at diagnosis the prognosis is poor.
USPSA Multigun Championship
The USPSA Multigun Championship, formerly called the 3-Gun Nationals, are yearly multigun championships held by the United States Practical Shooting Association (USPSA). The Multigun Championship is always held at a separate range and date from the pistol nationals USPSA Handgun Championship and IPSC US Handgun Championship. Currently, anyone can participate in the Multigun Championship on a first-come, first-served basis.

Multigun
Multigun, Multi Gun or Multi-Gun, often also called 2-Gun or 3-Gun depending on the types of firearms used, are practical shooting events where each of the stages require the competitor to use a combination of handguns, rifles, and/or shotguns Multigun has a lot in common with ordinary IPSC/ USPSA single gun matches, and matches generally have courses of fire where the shooter must move through different stages and engage targets in a variety of different positions.

Multigun in its oldest form is arranged by the International Practical Shooting Confederation (IPSC) as Tournaments, but doesn't require the competitor to transition between firearms during the stage. Instead tournaments consist of separate Component Matches for each firearm type with a combined scoring in the end.
Elia Galera
Elia Galera (born 19 March 1973) is a Spanish actress and television presenter.

Born in Madrid, Galera made her feature film debut in The Ugliest Woman in the World (1999). She became popular to a television audience for her role as Claudia Castilla in Hospital Central (2006−2011).

As a television presenter, also on Telecinco, she became popular as co-anchor of the Popstars contest, alongside Jesús Vázquez in 2002.

The Ugliest Woman in the World
The Ugliest Woman in the World (Spanish: La mujer más fea del mundo) is a 1999 Spanish science fiction comedy film directed by Miguel Bardem from a screenplay by Nacho Faerna which stars Elia Galera and Roberto Álvarez.
Antonio B. Won Pat International Airport
Antonio B. Won Pat International Airport (IATA: GUM, ICAO: PGUM) — also known as Guam International Airport — is an international airport located in Tamuning and Barrigada, three miles (4.8 km) east of the capital city of Hagåtña (formerly Agana) in the United States territory of Guam. The airport is a primary cargo hub for Asia Pacific Airlines. It is also the home of the former Naval Air Station Agana, and is the only international airport in the territory. The airport is named after Antonio Borja Won Pat, the first delegate from Guam to the United States House of Representatives, and is operated by the A.B. Won Pat International Airport Authority, Guam (GIAA, Chamorro: Aturidat Puetton Batkon Airen Guahan Entenasionat), an agency of the Government of Guam.

United Airlines
United Airlines, Inc. is a major airline in the United States headquartered in Chicago, Illinois. It operates an extensive domestic and international route network across the United States and to destinations on six continents. Regional service is provided by independent carriers operating under the United Express brand, and the Star Alliance, of which United was one of the five founding airlines, extends its network throughout the world.

The principal figure behind the formation of the airline was William E. Boeing, founder of the Boeing Aircraft Company in 1916. He launched an air service between Victoria, British Columbia, and Seattle and later acquired three additional airlines, completing the merger by 1931 to form United Air Lines. Through successive mergers and acquisitions, United has remained one of the largest airlines in the world for much of its history.
Gesualdo, Campania
Gesualdo is an Italian town in the province of Avellino, itself in the region of Campania. It is called "The city of the Prince of Musicians" in honour of Carlo Gesualdo. It has many palaces, fountains, belvederes, and a historical center, which was partially restored after the Irpinia earthquake in 1980.

The town is located in the center of Irpinia, between the valleys of the rivers Fredane and Ufita. It is about 90 kilometres (56 mi) from Naples and 290 kilometres (180 mi) from Rome. Surrounding municipalities are Fontanarosa, Frigento, Grottaminarda, Paternopoli, Villamaina. It is one of I Borghi più belli d'Italia ("The most beautiful villages of Italy").

Province of Avellino
The province of Avellino (Italian: provincia di Avellino) is a province in the Campania region of Italy. Its capital is the city of Avellino. The area is characterized by numerous small towns and villages scattered across the province; only two towns have a population over 20,000.