hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
CGMP-specific phosphodiesterase type 5
Cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme (EC 3.1.4.17) from the phosphodiesterase class. It is found in various tissues, most prominently the corpus cavernosum of the clitoris and of the penis as well as the retina. It has also been recently discovered to play a vital role in the cardiovascular system.

The phosphodiesterase (PDE) isozymes, found in several tissues including the rod and cone photoreceptor cells of the retina, belong to a large family of cyclic nucleotide PDEs that catalyze cAMP and cGMP hydrolysis.

The interest in PDEs as molecular targets of drug action has grown with the development of isozyme-selective PDE inhibitors that offer potent inhibition of selected isozymes without the side-effects attributed to nonselective inhibitors such as theophylline.

Sildenafil, vardenafil, tadalafil, and avanafil are PDE5 inhibitors that are significantly more potent and selective than zaprinast and other early PDE5 inhibitors.

Zaprinast
Zaprinast was an unsuccessful clinical drug candidate that was a precursor to the chemically related PDE5 inhibitors, such as sildenafil (Viagra), which successfully reached the market. It is a phosphodiesterase inhibitor, selective for the subtypes PDE5, PDE6, PDE9 and PDE11.  IC50 values are 0.76, 0.15, 29.0, and 12.0 μM, respectively.

Zaprinast inhibits the growth of asexual blood-stage malaria parasites (P. falciparum) in vitro with an ED50 value of 35 μM, and inhibits PfPDE1, a P. falciparum cGMP-specific phosphodiesterase, with an IC50 value of 3.8 μM.

Zaprinast has also been shown to activate the orphan G-protein coupled receptor known as GPR35, both in rats and humans, and to inhibit the mitochondrial pyruvate carrier.
Ryan North
Ryan North (born October 20, 1980) is a Canadian webcomic and comic book writer and computer programmer.

He is the creator and author of Dinosaur Comics, and has written for the comic series of Adventure Time and Marvel Comics' The Unbeatable Squirrel Girl, Fantastic Four, One World Under Doom, and Hulk: Smash Everything. His works have won multiple Eisner Awards and Harvey Awards and made New York Times Bestseller lists.

Machine of Death
Machine of Death is a 2010 collection of science fiction short stories edited by Ryan North, Matthew Bennardo, and David Malki. The stories featured in Machine of Death were submitted by various writers since early 2007 and all focus on a device which can accurately predict the manner in which the user will eventually die. The book became a #1 bestseller on Amazon.com shortly after its initial publication, and was later released online under a free license.
Quebec County (federal electoral district)
Quebec County (French: Comté de Québec) was a federal electoral district in Quebec, Canada, that was represented in the House of Commons of Canada from 1867 to 1925.

It was created by The British North America Act, 1867 which preserved existing ridings in Lower Canada.  It was abolished in 1924 when it was merged into Québec—Montmorency riding.

Québec—Montmorency
Québec—Montmorency (French pronunciation: [kebɛk mɔ̃mɔʁɑ̃si]) was a federal electoral district in Quebec, Canada, that was represented in the House of Commons of Canada from 1925 to 1968.

This riding was created in 1924 from parts of Charlevoix—Montmorency and Quebec County ridings.

It was abolished in 1966 when it was redistributed into Louis-Hébert, Montmorency and Portneuf ridings.
Ål Bygdamuseum
60°37′46.51″N 8°32′25.83″E﻿ / ﻿60.6295861°N 8.5405083°E﻿ / 60.6295861; 8.5405083
Ål Bygdamuseum, a small museum on the farm Leksvol in Ål municipality in Buskerud, Norway, is a subsidiary of Hallingdal Museum. It includes 30 old buildings, including the house from Leksvol farm which dates from about 1600, a mountain farm (støl) with a stone building, and a cotter's farm place.

Ål
Ål is a municipality in Buskerud county, Norway. It is part of the traditional region of Hallingdal.  The administrative centre of the municipality is the village of Ål.
The parish of Aal was established as a municipality on 1 January 1838 (see formannskapsdistrikt). The area of Hol was separated from the municipality of Aal in 1877 to become a separate municipality.
RAAF Base East Sale
RAAF Base East Sale (ICAO: YMES) is a Royal Australian Air Force (RAAF) military air base and training school, located in Sale, Victoria, Australia. The base is one of the main training establishments of the RAAF, and is where Australian Air Force Cadets from 4 Wing (Victoria) have their biannual General Service Training.

It is the home of the RAAF's Officers' Training School (OTS) following its relocation from RAAF Base Point Cook, the Air Mission Training School (AMTS), and the School of Air Traffic Control. East Sale was upgraded to house the new OTS, which had its first intake of students in January 2008. The base houses approximately 700 air force personnel. As well as being home to No. 409 Squadron Australian Air Force Cadets, it is home to the Roulettes aerobatic display team.

Sale, Victoria
Sale is a city situated in the Gippsland region of Victoria, Australia and the council capital of the Shire of Wellington. It had an estimated population of 15,305 in 2022 according to the Australian Bureau of Statistics. The total population including the immediate area around the town is approximately 19,000 according to shire website.
Giovanni Pettinato
Giovanni Pettinato (30 April 1934, in Troina – 19 May 2011, in Rome) was an Assyriologist and paleographer of writings from the ancient Near East, specializing in the Eblaite language, His major contributions to the field include the deciphering of the Eblaite script, discovered by Paolo Matthiae in 1974–75.

Pettinato graduated from Heidelberg in 1968, where he had studied for ten years. In 1968 he began teaching Assyriology at the University of Rome.

Pettinato died on 19 May 2011 at the age of 76. He was an emeritus of several associations, including the Accademia dei Lincei and authored several publications about the Sumerian and Mesopotamian civilizations.

Eblaite language
Eblaite (/ˈɛblə.aɪt, ˈiːblə-/, also known as Eblan ISO 639-3), or Palaeosyrian, is an extinct East Semitic language used during the 3rd millennium BC in Northern Syria. It was named after the ancient city of Ebla, in modern western Syria. Variants of the language were also spoken in Mari and Nagar. According to Cyrus H. Gordon, although scribes might have spoken it sometimes, Eblaite was probably not spoken much, being rather a written lingua franca with East and West Semitic features.

The language was discovered through cuneiform tablets found in Ebla.
Claquebue Island
Claquebue Island is a rocky island 0.5 kilometres (0.25 nmi) long, lying 0.1 kilometres (0.05 nmi) east of Dru Rock in the Curzon Islands. It was charted in 1951 by the French Antarctic Expedition and named by them, for the village in La Jument Verte, a novel much read and appreciated by members of the French expedition.

Dru Rock
Dru Rock is a rocky island 0.28 kilometres (0.15 nmi) long between Retour Island and Claquebue Island in the Curzon Islands. The island is home to many craggy rock faces, which make climbing difficult.
Carlstadt Public Schools
The Carlstadt Public Schools is a community public school district that serves students in pre-kindergarten through eighth grade from the Borough of Carlstadt in Bergen County, in the U.S. state of New Jersey.

As of the 2023–24 school year, the district, comprised of one school, had an enrollment of 523 students and 43.5 classroom teachers (on an FTE basis), for a student–teacher ratio of 12.0:1.

For ninth through twelfth grades, public school students attend the Henry P. Becton Regional High School in East Rutherford, which serves high school students from both Carlstadt and East Rutherford as part of the Carlstadt-East Rutherford Regional School District, together with students from Maywood, who attend as part of a sending/receiving relationship. As of the 2023–24 school year, the high school had an enrollment of 821 students and 61.5 classroom teachers (on an FTE basis), for a student–teacher ratio of 13.4:1.

Carlstadt, New Jersey
Carlstadt is a borough in Bergen County, in the U.S. state of New Jersey. As of the 2020 United States census, the borough's population was 6,372, an increase of 245 (+4.0%) from the 2010 census count of 6,127, which in turn reflected an increase of 210 (+3.5%) from the 5,917 counted in the 2000 census.

Carlstadt was originally formed as a village by an act of the New Jersey Legislature on March 12, 1860, within Lodi Township. Most sources indicate that the community was named for Carl Klein, the leader of a group of early German settlers who led the project to establish the community though Henry Gannett stated that the name derived from the city of Karlovac in Croatia, which was known as "Carlstadt" in German. The Borough of Carlstadt was incorporated on June 27, 1894, formally set off from Bergen Township. The borough was formed during the "Boroughitis" phenomenon then sweeping through Bergen County, in which 26 boroughs were formed in the county in 1894 alone.
Mademoiselle Fleury
Marie-Anne-Florence Bernardy-Nones (28 December 1766, Antwerp - 23 February 1818, Orly), known as Mademoiselle Fleury (Miss Fleury), was an actress active in France.

Her father (Louis-Joseph Nones, known as Fleury) and mother (Marie-Anne-Denise Bernardy, daughter of Charles Bernardy) were comic actors in the provinces who often appeared in the Austrian Netherlands.

Mademoiselle Fleury débuted at the Comédie-Française on 21 January 1786 and was received into the company on 23 October. She became a sociétaire in 1791 and retired in 1807.

Sociétaires of the Comédie-Française
The sociétaires of the Comédie-Française are chosen from among the pensionnaires who have been in the company a year or more.

They are decided upon in the course of a general assembly of the company's administrative committee, made up of six existing sociétaires, the senior sociétaire, and the general administrator.  A pensionnaire is thus named a societaire by a decree of the Ministry of Culture, from names put forward by the general administrator of the Comédie-Française.  On becoming a sociétaire, an actor automatically becomes a member of the Société des Comédiens-Français and receives a share of the profits as well as receiving a number of shares in the société to which he or she is contractually linked.

After his or her retirement, a sociétaire can continue to act, becoming an honorary sociétaire.  The senior member of the Comédie-Française is not the oldest sociétaire, but the sociétaire who has been with the company longest (since their entering it as a pensionnaire).
BK-5F-NM-AMT
BK-5F-NM-AMT, or βk-5F-NM-αMT, also known as β-keto-5-fluoro-N-methyl-αMT or α,N-dimethyl-5-fluoro-β-ketotryptamine, is a monoamine releasing agent of the tryptamine, α-alkyltryptamine, and β-ketotryptamine families.

It is known to induce the release of serotonin and dopamine, with respective EC50Tooltip half-maximal effective concentration values of 190 nM and 620 nM in rat brain synaptosomes, whereas norepinephrine release was not reported. In contrast to many other tryptamines, the drug is inactive as an agonist of serotonin receptors including the 5-HT1, 5-HT2, and 5-HT3 receptors. In addition, unlike other α-alkyltryptamines like α-methyltryptamine (αMT), it is inactive as a monoamine oxidase inhibitor (MAOI).

BK-5F-NM-AMT was first described in the literature by 2023. It was patented by Matthew Baggott and Tactogen as a potential novel entactogen. BK-5F-NM-AMT is the 5-fluoro derivative of BK-NM-AMT. Other analogues of the drug include BK-5Cl-NM-AMT and BK-5Br-NM-AMT.

Tactogen
Tactogen is a public benefit corporation and start-up pharmaceutical company based in Palo Alto, California that is developing novel MDMA-like entactogens and psychedelics as medicines. Its stated goal is to develop new MDMA-like drugs with improved effectiveness, tolerability, and safety, as well as gentleness and accessibility, for treatment of psychiatric disorders and other conditions. Tactogen was co-founded by neuroscientist Matthew J. Baggott and Luke Pustejovsky in 2020. Baggott is the chief executive officer (CEO) while Pustejovsky is the chief operating officer (COO).
Subsea technology
Subsea technology involves fully submerged ocean equipment, operations, or applications, especially when some distance offshore, in deep ocean waters, or on the seabed. The term subsea is frequently used in connection with oceanography, marine or ocean engineering, ocean exploration, remotely operated vehicle (ROVs) autonomous underwater vehicles (AUVs), submarine communications or power cables, underwater habitats, seafloor mineral mining,  oil and gas, and offshore wind power.

Christmas tree (oil well)
In petroleum and natural gas extraction, a Christmas tree, or tree, is an assembly of valves, casing spools, and fittings used to regulate the flow of pipes in an oil well, gas well, water injection well, water disposal well, gas injection well, condensate well, and other types of well.
Rotterdam Centraal station
Rotterdam Centraal station (Dutch pronunciation: [ˌrɔtərˈdɑm sɛnˈtraːl]; English: Rotterdam Central station) is the main railway station of the city Rotterdam in South Holland, Netherlands. The station received an average of 112,000 passengers daily in 2019. The current station building, located at Station Square, was officially opened in March 2014.

Nederlandse Spoorwegen
Nederlandse Spoorwegen ([ˈneːdərlɑntsə ˈspoːrˌʋeːɣə(n)] ⓘ, lit. 'Dutch Railways', NS [ɛnˈɛs] ⓘ) is the principal passenger railway operator in the Netherlands. It is a Dutch state-owned company founded in 1938.

The rail infrastructure is maintained by network manager ProRail, which was split off from NS in 2003. Freight operator NS Cargo merged with DB Cargo in 2000. NS runs 4,800 scheduled domestic trains a day, serving 1.1 million passengers. The NS also provides international rail services from the Netherlands to other European destinations and carries out concessions on some foreign rail markets through its subsidiary Abellio.
Oklahoma Bureau of Narcotics and Dangerous Drugs Control
The Oklahoma Bureau of Narcotics and Dangerous Drugs Control (OBN), often shortened to Oklahoma Bureau of Narcotics, is an agency of the government of Oklahoma charged with minimizing the abuse of controlled substances through law enforcement measures directed primarily at drug trafficking, illicit drug manufacturing, and major suppliers of illicit drugs.

The Bureau is governed by a seven-member commission whose members are appointed by the Governor of Oklahoma with the approval of the Oklahoma Senate. The commission is responsible for appointing a director. Donnie Anderson was appointed Director in March 2020.

Oklahoma State Bureau of Investigation
The Oklahoma State Bureau of Investigation (OSBI) is an independent state law enforcement agency of the government of Oklahoma. The OSBI assists the county sheriff offices and city police departments of the state, and works independent of the Oklahoma Department of Public Safety to investigate criminal law violations within the state at the request of statutory authorized requesters. The OSBI was created in 1925 during the term of Governor Martin E. Trapp.

The OSBI is governed by a seven-member commission, with each member of the commission appointed by the Governor of Oklahoma. The commission then appoints a director, who serves at the pleasure of the commission, as the chief executive officer of the OSBI. The current director is Greg Mashburn and was appointed to serve as Director on March 3, 2025.
Canon (fiction)
The canon of a work of fiction is "the body of works taking place in a particular fictional world that are widely considered to be official or authoritative; [especially] those created by the original author or developer of the world". Canon is contrasted with, or used as the basis for, works of fan fiction and other derivative works.

Parallel universes in fiction
A parallel universe, also known as an alternate universe, world, or dimension, is a plot device in fiction which uses the notion of a hypothetical universe co-existing with another, typically to enable alternative narrative possibilities. The sum of all potential parallel universes that constitute reality is often called the "multiverse".

The device serves several narrative purposes. Among them, parallel universes have been used to allow stories with elements that would ordinarily violate the laws of nature, to enable characters to meet and interact with alternative versions of themselves or others from their home universe, thus enabling further character development, and to serve as a starting point for speculative fiction, particularly alternate history.
John Harpeden I
Sir John Harpeden (or Harpsden; French: Jean Harpedenne) was an English knight and administrator who served Edward III of England in France during the Hundred Years' War. He served as seneschal of Saintonge (1371–72) and seneschal of Aquitaine (1385–89). His descendants became French lords. He is called John Harpeden I or John Harpeden the Elder to distinguish him from his son, Jean Harpedenne II.

Seneschal of Gascony
The Seneschal of Gascony was an officer carrying out and managing the domestic affairs of the lord of the Duchy of Gascony. During the course of the twelfth century, the seneschalship also became an office of military command. After 1360, the officer was the Seneschal of Aquitaine. There was an office above the seneschalcy, the Lieutenancy of the Duchy of Aquitaine, but it was filled only intermittently (in times of emergency).

The seneschal managed the household, coordinating between the receivers of various landholdings and the chamber, treasury, and the chancellory or chapel. The seneschals of Gascony, like those appointed in Normandy, Poitou, and Anjou, had custody of demesne fortresses, the regional treasuries, and presidency of the highest court of regional custom. Detailed records of the Gascon Exchequers during the reign of Henry III of England indicate that there most likely was a functioning exchequer.
Kadıköy İnciburnu Lighthouse
The Kadıköy İnciburnu Feneri (aka Kadıköy Feneri or İnciburnu Feneri) is a lighthouse located at the head of Kadıköy Harbor's İnciburnu Breakwater on the Anatolian coast of Bosporus' south entrance, in Kadıköy district of Istanbul, Turkey. It is across from the Ahırkapı Feneri, which is on the Rumelian coast of the strait at a distance of 1.5 nmi (2.8 km; 1.7 mi). A line connecting the two lighthouses marks the southern boundary of the Port of Istanbul.

The lighthouse with an 11 m (36 ft) high tower is constructed in concrete and painted white.  It went on October 13, 1977, in service.

Kadıköy İnciburnu Feneri is equipped with a lantern of type Tideland ML-300 featuring a one-piece acrylic Fresnel lens of 300mm focal length. It is powered by solar energy producing 35 W.

At a focal height of 14 m (46 ft), it flashes white 2 seconds long every 4 seconds, which is visible at a range of 13 nmi (24 km; 15 mi) in the Sea of Marmara.

Bosporus
The Bosporus or Bosphorus Strait is a natural strait and an internationally significant waterway located in Turkey which is straddled by the city of  Istanbul. The Bosporus connects the Black Sea to the Sea of Marmara and forms one of the continental boundaries between Asia and Europe. It also divides Turkey by separating Asia Minor from Thrace. It is the world's narrowest strait used for international navigation.

Most of the shores of the Bosporus Strait, except for the area to the north, are heavily settled, with the city of Istanbul's metropolitan population of 17 million inhabitants extending inland from both banks.

The Bosporus Strait and the Dardanelles Strait at the opposite end of the Sea of Marmara are together known as the Turkish Straits.

Sections of the shore of the Bosporus in Istanbul have been reinforced with concrete or rubble and those sections of the strait prone to deposition are periodically dredged.
Satan's Choice Motorcycle Club
Satan's Choice Motorcycle Club (SCMC) is a Canadian outlaw motorcycle club. Once the dominant outlaw club in Ontario, with twelve chapters based in the province, and another in Montreal, Quebec, at its peak strength in 1977. Satan's Choice grew to more than 400 members by 1970, making it the second largest outlaw motorcycle club in the world, behind only the Hells Angels.

The club was involved in the first major outlaw biker conflict in Canadian history, when it engaged the country's second largest club, the Popeyes, from 1974 to 1976. Satan's Choice's power began to diminish during the late 1970s, with some of the club's chapters "patching over" to the Outlaws in 1977. The remaining chapters would eventually become members of the Hells Angels, along with most of the other major outlaw clubs in Ontario, in 2000. In 2017 the club was reactivated briefly but quickly shut down. In 2025 the club was reactivated by Harley Davidson Guindon, son of former President Bernie Guindon.

Outlaw motorcycle club
An outlaw motorcycle club, known colloquially as a biker club or bikie club (in Australia), is a motorcycle subculture generally centered on the use of cruiser motorcycles, particularly Harley-Davidsons and choppers, and a set of ideals that purport to celebrate freedom, nonconformity to mainstream culture and loyalty to the biker group. The subculture emerged in the United States in the late 1940s and has since spread globally.

In the United States, such motorcycle clubs (MCs) are considered "outlaw" not necessarily because they engage in criminal activity but because they are not sanctioned by the American Motorcyclist Association (AMA) and do not adhere to the AMA's rules. Instead, the clubs have bylaws reflecting the outlaw biker culture.

The U.S. Department of Justice defines "outlaw motorcycle gangs" (OMG) as "organizations whose members use their motorcycle clubs as conduits for criminal enterprises".
Short-snouted seahorse
The short-snouted seahorse (Hippocampus hippocampus) is a species of seahorse in the family Syngnathidae. It is endemic to the Mediterranean Sea and parts of the North Atlantic, particularly around Italy, Portugal, Spain  and the Canary Islands, with small populations extending from the Atlantic into the North Sea.

Their preferred habitat is shallow muddy waters, estuaries, or seagrass beds.

Seahorse
A seahorse (also written sea-horse and sea horse) is any of 46 species of small marine bony fish in the genus Hippocampus. The genus name comes from the Ancient Greek hippókampos (ἱππόκαμπος), itself from híppos (ἵππος) meaning "horse" and kámpos (κάμπος) meaning "sea monster" or "sea animal". Having a head and neck suggestive of a horse, seahorses also feature segmented bony armour, an upright posture and a curled prehensile tail. Along with the pipefishes and seadragons (Phycodurus and Phyllopteryx) they form the family Syngnathidae.