hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
JAK-STAT signaling pathway
The JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death, and tumor formation. The pathway communicates information from chemical signals outside of a cell to the cell nucleus, resulting in the activation of genes through the process of transcription. There are three key parts of JAK-STAT signalling: Janus kinases (JAKs), signal transducer and activator of transcription proteins (STATs), and receptors (which bind the chemical signals). Disrupted JAK-STAT signalling may lead to a variety of diseases, such as skin conditions, cancers, and disorders affecting the immune system.

Janus kinase inhibitor
A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, is a type of immune modulating medication, which inhibits the activity of one or more of the Janus kinase family of enzymes (JAK1, JAK2, JAK3, TYK2), thereby interfering with the JAK-STAT signaling pathway in lymphocytes.

JAK inhibitors are used in the treatment of some cancers and inflammatory diseases such as rheumatoid arthritis and various skin conditions. A Janus kinase 3 inhibitor is attractive as a possible treatment of various autoimmune diseases since its function is mainly restricted to lymphocytes. JAK inhibitors can suppress the signaling of pro-inflammatory cytokines. Pro-inflammatory cytokines are major contributors to the cause of an over active immune system, resulting in inflammation and pain. JAK inhibitors have the ability to slow down this over activity by the suppression of the intracellular signaling.
2009 NCAA Division I baseball season
The 2009 NCAA Division I baseball season play of college baseball in the United States, organized by the National Collegiate Athletic Association (NCAA) at the Division I level, began on February 20, 2009.  The season progressed through the regular season, many conference tournaments and championship series, and concluded with the 2009 NCAA Division I baseball tournament and 2009 College World Series.  The College World Series, which consisted of the eight remaining teams in the NCAA tournament, was held in its annual location of Omaha, Nebraska, at Rosenblatt Stadium.  It concluded on June 24, 2009, with the final game of the best of three championship series.  LSU defeated Texas two games to one to claim their sixth championship.

2009 LSU Tigers baseball team
The 2009 LSU Tigers baseball team represented Louisiana State University in the NCAA Division I baseball season of 2009. This was the first year for the team in the new Alex Box Stadium.

The 2009 team was coached by Paul Mainieri who was in his third season at LSU. During his first year at LSU, Mainieri's team posted a 29–26–1 record, but failed to make the SEC tournament or the NCAA tournament. The team improved during his second year posting a 49–19–1 record, while claiming the SEC Western Division Title, SEC Tournament championship, and earned the No. 7 National Seed for the 2008 NCAA tournament. They advanced to the 2009 College World Series where they would win the national title, their first since 2000, and 6th overall.
Dunøyane Bird Sanctuary
Dunøyane Bird Sanctuary (Norwegian: Dunøyane fuglereservat) is a bird reserve in Svalbard, Norway, established in 1973. It includes islands west of Dunøysundet in Wedel Jarlsberg Land. The protected area covers a total of around 11.9 km2.

The island group of Dunøyane is a nesting site for barnacle goose, common eider and Arctic tern.

Dunøyane
Dunøyane is a group of islands north of Hornsund, outside Wedel Jarlsberg Land at the western coast of Spitsbergen, Svalbard. The island group is a nesting site for barnacle goose, common eider and Arctic tern. Hunters used to collect eiderdown at the islands. Dunøyane are included in the Dunøyane Bird Sanctuary, and part of the Sør-Spitsbergen National Park.
Irvine Ranch Water District
Irvine Ranch Water District (IRWD) is a special district formed in 1961 and incorporated under the California water code. The IRWD headquarters is located in Irvine, California.

IRWD offers potable water sales, sewer service, and the sale of reclaimed (or recycled) water. IRWD serves the city of Irvine, portions of Costa Mesa, Lake Forest, Newport Beach, Orange, and Tustin, and unincorporated areas of Orange County.

Costa Mesa, California
Costa Mesa (/ˌkoʊstə ˈmeɪsə/ KOH-stə MAY-sə; Spanish for 'Mesa Coast') is a city in Orange County, California, United States. Since its incorporation in 1953, the city has grown from a semi-rural farming community of 16,840 to an urban area including part of the South Coast Plaza–John Wayne Airport edge city, one of the region's largest commercial clusters, with an economy based on retail, commerce, and light manufacturing. The population was 111,918 at the 2020 census.
Assemini
Assemini (Italian: [asˈsɛːmini]; Sardinian: Assèmini [aˈsemini]) is a comune (municipality) in the Metropolitan City of Cagliari in the Italian region of Sardinia, located about 12 kilometres (7 mi) northwest of Cagliari in the plain of the Cixerri, Flumini Mannu and Sa Nuxedda rivers. It has 25,577 inhabitants.

It includes forest areas which are part of the Sulcis Regional Park. It also has a long tradition in the production of ceramics, starting in the Carthaginian era.

Assemini is part of the Cagliari metropolitan area and borders the following municipalities: Cagliari, Capoterra, Decimomannu, Elmas, Nuxis, San Sperate, Santadi, Sarroch, Sestu, Siliqua, Uta and Villa San Pietro.

Nuxis
Nuxis (Sardinian: [ˈnuʒizi], Italian: [ˈnuːʒis]) is a comune (municipality) in the Province of Sulcis Iglesiente in the Italian region Sardinia, located about 35 kilometres (22 mi) west of Cagliari and about 20 kilometres (12 mi) east of Carbonia.

Nuxis borders the following municipalities: Assemini, Narcao, Santadi, Siliqua, Villaperuccio.
Cabinet of Mexico
The Cabinet of Mexico is the Executive Cabinet (Spanish: Gabinete Legal) and is a part of the executive branch of the Mexican government. It consists of nineteen Secretaries of State and the Legal Counsel of the Federal Executive.

In addition to the legal Executive Cabinet there are other Cabinet-level administration offices that report directly to the President of the Republic (Gabinete Ampliado). Officials from the legal and extended Cabinet (Gabinete Legal y Ampliado) are subordinate to the President.

Legal Counsel of the Federal Executive
The Legal Counsel of the Federal Executive (Consejero Jurídico del Ejecutivo Federal, CJEF) is a government official who, alongside the 19 secretaries of state, is a member of the cabinet of the President of Mexico. The purpose of the office of the legal counsel (Consejería Jurídica del Ejecutivo Federal) is to review and validate legal instruments that are submitted to the president for consideration, such as decrees, agreements, legislative bills or constitutional reforms. Its other tasks include drafting or assisting in the drafting of bills that are to be presented to the Congress of the Union. It also represents the president in unconstitutionality actions or constitutional controversies as provided for in the Constitution and represents him or her in all lawsuits in which he or she is a party.
Manitoba Provincial Road 304
Provincial Road 304 (PR 304) is a provincial road in the Eastman and NorMan regions of Manitoba, Canada. It begins at PTH 59/PTH 12 south of Grand Beach and runs to Powerview-Pine Falls at the PTH 11 junction. Near the town, PR 304 crosses the Winnipeg River at the Pine Falls Generating Station, operated by Manitoba Hydro. From there, PR 304 heads north and then east to the community of Bissett, before terminating at Provincial Road 314 near the northern boundary of Nopiming Provincial Park.

Provincial Roads 304, 313, 314, and 315, along with PTH 11, form a loop that provides access to several remote communities, First Nations reserves, and provincial parks on the eastern side of Lake Winnipeg. PR 304 is also used as a south terminus for winter roads to northern Manitoba.

Manitoba Provincial Road 315
Provincial Road 315 (PR 315) is a 59-kilometre-long (37 mi) east-west highway in the Eastman Region of Manitoba, Canada. It begins at PR 313 northeast of Lac du Bonnet and ends at the Ontario boundary, running through the southern part of Nopiming Provincial Park.

Provincial Roads 304, 313, 314, and 315, along with PTH 11, form a loop that provides access to several remote communities, First Nations, and provincial parks on the eastern side of Lake Winnipeg.
Kenneth Hahn Hall of Administration
Kenneth Hahn Hall of Administration (abbreviated HOA), formerly the Los Angeles County Hall of Administration, completed 1960, is the seat of the government of the County of Los Angeles, California, United States. The seat houses the Los Angeles County Board of Supervisors, meeting chambers, and the offices of several County departments. It is located in the Civic Center district of downtown Los Angeles, encompassing a city block bounded by Grand, Temple, Hill, and Grand Park.

On an average workday, 2,700 civil servants occupy the building.

Hill Street (Los Angeles)
Hill Street is a major north–south thoroughfare in Los Angeles, measuring 4.8 miles (7.7 km) in length. It starts on Martin Luther King, Jr. Boulevard near the campus of USC, and passes north through Downtown Los Angeles, past such landmarks as Pershing Square, the Subway Terminal Building, Angels Flight, Fort Moore and Chinatown. Hill Street merges with the Arroyo Seco Parkway near Dodger Stadium.
Early Byzantine mosaics in the Middle East
Early Byzantine mosaics in the Middle East are a group of Christian mosaics created between the 4th and the 8th centuries in ancient Syria, Israel, Palestine, Transjordan and Egypt when the area belonged to the Byzantine Empire. The eastern provinces of the Eastern Roman Empire and its continuation, the Byzantine Empire, inherited a strong artistic tradition from pagan Late Antiquity. The tradition of making mosaics was carried on in the Umayyad era until the end of the 8th century. The great majority of these works of art were later destroyed but archeological excavations unearthed many surviving examples.

Taybat al-Imam
Taybat al-Imam (Arabic: طيبة الإمام, also transliterated Tayyibat al-Imam or Taibet el-Imam), historically known as Tayyibat al-A'la, is a town in northern Syria, administratively part of the Hama Governorate, located 18 kilometers (11 mi) northwest of Hama. Nearby localities include Halfaya and Mhardeh to the west, Lataminah to the northwest, Morek to the north, Suran to the east, Maar Shuhur to the southeast, Qamhana to the south and Khitab to the southwest. According to the Syria Central Bureau of Statistics (CBS), Taybat al-Imam had a population of 24,105 in the 2004 census.
Hudson–Athens Lighthouse
The Hudson–Athens Lighthouse, sometimes called the Hudson City light, is a lighthouse located in the Hudson River in the state of New York in the United States. The light is located between Hudson on the east bank and Athens on the west, closer to the Hudson side. Constructed in 1874, it marks a sandy ridge known as Middle Ground Flats and also acts as a general aid to navigation of the river. The station is built on a granite caisson with an unusual shape designed to protect it from ice floes and river debris. The dwelling is constructed in the Second Empire architectural style,
with a mansard roof. It is considered to be virtually a twin of the Stepping Stones Light in Long Island Sound, which was constructed just a few years later.

Hudson, New York
Hudson is a city in and the county seat of Columbia County, New York, United States. At the 2020 census, it had a population of 5,894. On the east side of the Hudson River, 120 miles (190 km) from the Atlantic Ocean, it was named after the river's explorer, Henry Hudson.

Often called the "Brooklyn of Upstate New York", Hudson is a tourist destination known for its antique shops and boutiques.
Formula Super Vee
Formula Super Vee was an open-wheel racing series that took place in Europe and the United States from 1970 to 1990. The formula was created as an extension of Formula Vee, a racing class that was introduced in 1959. Formula Super Vee in Europe was similar to F3 or Formula Renault  today, a stepping stone to F1. In the United States, Formula Super Vee, often referred to as Super Vee, was a natural progression to Indy Car and Can-Am. On both sides of the Atlantic the series also was a platform for the promotion of VW products, similar to how Formula Renault promotes Renault products today.

Initially it was seen as a simple step up from Formula Vee, using Volkswagen air-cooled engines, only Type 3 engines in 1600cc as opposed to Type 1 engines in 1200cc or 1600cc. However it soon transformed to using the very different and more powerful fuel injected water-cooled engines from the VW Golf/Rabbit.

Formula Three
Formula Three (F3) is a third-tier class of open-wheel formula racing. The various championships held in Europe, Australia, South America and Asia form an important step for many prospective Formula One drivers.
Claire-Clémence de Maillé-Brézé
Claire Clémence de Maillé (25 February 1628 – 16 April 1694) was a French noblewoman from the Brézé family and a niece of Cardinal Richelieu. She married Louis de Bourbon, Prince of Condé, known as Le Grand Condé (The Great Condé), and became the mother of Henri Jules. She was Princess of Condé and Duchess of Fronsac.

Prince du sang
A prince du sang (French pronunciation: [pʁɛ̃s dy sɑ̃]) or prince of the blood is a person legitimately descended in male line from a sovereign. The female equivalent is princesse du sang (princess of the blood), being applied to the daughter of a prince of the blood. The most prominent examples include members of the French royal line, but the term prince of the blood has been used in other families more generally, for example among the British royal family and when referring to the Shinnōke in Japan.

In some European kingdoms, especially France, this appellation was a specific rank in its own right, with a more restricted use than other titles.  In France, such rank recognised succession to the throne, should the main male royal line fail, as with the House of Valois succeeded by the House of Bourbon.
Fast Low-Ionization Emission Region
A Fast Low-Ionization Emission Region, or FLIER, is a volume of gas with low ionization, moving at supersonic speeds, near the symmetry axis of many planetary nebulae. Their outflow speeds are significantly higher than the nebulae in which they are embedded, and their ionizations are much lower. FLIERs' high speeds suggest ages much younger than their parent nebulae, and their low ionizations indicate that the ultraviolet radiation that ionizes the gas around them does not penetrate into the FLIERs. The Blinking Planetary features a set of FLIERs.

NGC 6826
NGC 6826 (also known as Caldwell 15) is a planetary nebula located  in the constellation Cygnus. It is commonly referred to as the "Blinking Planetary", although many other nebulae exhibit such "blinking". When viewed through a small telescope, the brightness of the central star overwhelms the eye when viewed directly, obscuring the surrounding nebula. However, it can be viewed well using averted vision, which causes it to "blink" in and out of view as the observer's eye wanders.

A distinctive feature of this nebula are the two bright patches on either side, which are known as Fast Low-Ionization Emission Regions, or FLIERS. They appear to be relatively young, moving outwards at supersonic speeds.

HD 186924 is the central star of the planetary nebula. It is an O-type star with a spectral type of O6fp.
Associação Atlética Anapolina
Associação Atlética Anapolina, or Anapolina as they are usually called, is a Brazilian football team from Anápolis in Goiás, founded on January 1, 1948.

Anapolina greatest rival is Anápolis.

Home stadium is the Jonas Duarte stadium, capacity 19,000. They play in red shirts, shorts and socks.

Anápolis Futebol Clube
Anápolis Futebol Clube, known simply as Anápolis, are a Brazilian football team based in Anápolis, Goiás. They competed in the Campeonato Brasileiro Parallel Tournament in 1986 and in the Série C in 2008.
Vicki Keith
Dr. Vicki Keith Munro, CM, O.Ont, LLD, ChPC (born 26 February 1961 in Winnipeg, Manitoba) is a Canadian retired marathon swimmer, coach and advocate for disabled athletes. Her accomplishments include the first crossing of all five Great Lakes, a 100-hour swim and the world record distance of 80.2 kilometers swum using the butterfly stroke. Many people consider Keith as the face of marathon swimming.

Canadian Disability Hall of Fame
The Canadian Disability Hall of Fame (formerly the Terry Fox Hall of Fame), recognizes "outstanding Canadians who have made extraordinary contributions to enriching the quality of life for people with physical disabilities". It is run by the Canadian Foundation for Physically Disabled Persons and located at Metro Hall, 55 John St., in downtown Toronto. The Hall is named after Terry Fox, a cancer research activist who attempted a run across Canada, dubbed the "Marathon of Hope".
Computer Bismarck
Computer Bismarck is a computer wargame developed and published by Strategic Simulations (SSI) in 1980. The game is based on the last battle of the battleship Bismarck, in which British Armed Forces pursue the German Bismarck in 1941. Computer Bismarck is SSI's first game and features turn-based gameplay on a two-dimensional map of the Atlantic Ocean.

The development staff consisted of two programmers, Joel Billings and John Lyons, who programmed the game in BASIC. Originally developed for the TRS-80, an Apple II version was also created two months into the process. After meeting with other wargame developers, Billings decided to publish the game as well. To help accomplish this, he hired Louis Saekow to create the box art.

The first commercially published computer war game, Computer Bismarck sold well and contributed to SSI's success. Though it received a mixed reception, the game is credited in part for legitimizing war games and computer games.

Strategic Simulations
Strategic Simulations, Inc. (SSI) was a video game developer and publisher of over 100 games from its founding in 1979 to its dissolution in 1994 (though the brand was in use until around 2002). The company focused on computer wargames then later added role-playing video games. SSI published the Panzer General series and the official video game adaptations of Dungeons & Dragons.
Ōtomo Chikasada
Ōtomo Chikasada (大友 親貞; ? – 1570) a retainer of the Japanese clan of Ōtomo clan during the Sengoku period of the 16th century. Chikasada was the younger brother of the famous Ōtomo Sōrin. Throughout Chikasada's career, he led many an army throughout Sorin's campaigns in Chikugo, Buzen, and other provinces.

Following the year of 1570 Chikasada was assigned with over 60,000 troops to completely wipe out the Ryūzōji clan of Hizen Province. However, throughout this battle Chikasada failed in this attempt and died in the process. The rest of his army ended up being defeated at the Battle of Imayama in September of that same year.

Ōtomo clan
The Ōtomo clan (大友氏, Ōtomo-shi) was a Japanese samurai family whose power stretched from the Kamakura period through the Sengoku period, spanning over 400 years. The clan's hereditary lands lay in Kyūshū.
Alan Davis (priest)
Alan Norman Davis (27 July 1938 – 3 March 2021) was an Anglican priest who was Archdeacon of West Cumberland from 1996 until 2004.

Davis was educated at King Edward's School, Birmingham; Durham University and Lichfield Theological College; and ordained in 1966. After a curacy in Birmingham at St Luke's, Kingstanding (1965–68), he was Priest in charge at St Paul, Sheffield, then Vicar of St James and St Christopher, Shiregreen. He was Team Rector of Maltby from 1980 to 1989; Archbishop of York's Officer for Urban Priority Areas from 1990 to 1992; and Communications Officer for the Diocese of Carlisle from 1992 to 1996.

He died in 2021, aged 82.

Archdeacon of West Cumberland
The Archdeacon of West Cumberland is responsible for the archdeaconry of West Cumberland, one of three administrative divisions of the Church of England (Anglican) Diocese of Carlisle. The archdeaconry was created (mostly from the Archdeaconry of Westmorland but with a little territory from Furness and Carlisle archdeaconries) by Order-in-Council on 7 August 1959.
2010 Boston water emergency
The 2010 Boston water emergency occurred on May 1, 2010, when a water pipe in Weston, Massachusetts, broke and began flooding into the Charles River. This led to unsanitary water conditions in the greater Boston area, which resulted in Governor Deval Patrick declaring a state of emergency and an order for residents to boil drinking water. The leak was stopped on May 2. On May 4, the order was lifted. President Barack Obama signed an emergency disaster declaration offering federal help, authorizing the Department of Homeland Security and Federal Emergency Management Agency to coordinate disaster relief efforts with Massachusetts.

MWRA executive director Frederick Laskey called the break "catastrophic" and "everyone's worst nightmare in the water industry".

Massachusetts Water Resources Authority
The Massachusetts Water Resources Authority (MWRA) is a public authority in the Commonwealth of Massachusetts that provides wholesale drinking water and sewage services to 3.1 million people in sixty-one municipalities and more than 5,500 large industrial users in the eastern and central parts of the state, primarily in the Boston area.

The authority receives water from the Quabbin and Wachusett Reservoirs and the Ware River in central and western Massachusetts. For sewage, it operates a large treatment center on Deer Island at the mouth of Boston Harbor, among other properties.

The modern MWRA was created in 1985 after being split from the Metropolitan District Commission. It gained the ability to raise its own revenues and issues its own bonds. The Department of Conservation and Recreation is the successor to the MDC, and still maintains the watershed lands.
Osiedle
Osiedle [ɔˈɕɛdlɛ] (Polish plural: osiedla) is a term used in Poland to denote a designated subdivision or neighbourhood of a city or its dzielnica, or of a town, with its own council and executive. Like the dzielnica and sołectwo, an osiedle is an auxiliary unit (jednostka pomocnicza) of a gmina. These units are created by decision of the gmina council, and do not have legal personality in their own right. In the case of an urban-rural gmina, it is also possible for a whole town to be designated an auxiliary unit.

Not all Polish cities or towns have osiedla in the above sense. However the word osiedle is also frequently used to denote any housing estate or development.

Sołectwo
A sołectwo [sɔˈwɛt͡stfɔ] ⓘ (Polish plural: sołectwa) is an administrative unit in Poland, an optional subdivision of a gmina. The actions and organs of the sołectwo are decided by the gmina council. On 31 December 2018 Poland had 40 740 sołectwa.
Bijin station
Bijin  is a station on Line 3 of Chongqing Rail Transit in Chongqing Municipality, China, which opened in 2011. It is located in Yubei District. The station also serves as the southern terminus of the Konggang Branch of Line 3.

Yubei, Chongqing
Yubei District (Chinese: 渝北区; pinyin: Yúběi Qū), literally meaning the north of Yu (with Yu being an abbreviation for Chongqing), was a former district of Chongqing municipality, bordering Sichuan province to the north. Lianglu, which is a town administered by Yubei District, is where the Chongqing Jiangbei International Airport is located. It's now a part of Liangjiang New Area.