hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Thymidylate synthase
Thymidylate synthase (TS) (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP).  Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP arise. Both cause DNA damage.

Thymidylate synthase inhibitor
Thymidylate synthase inhibitors are chemical agents which inhibit the enzyme thymidylate synthase and have potential as an anticancer chemotherapy. This inhibition prevents the methylation of C5 of deoxyuridine monophosphate (dUMP) thereby inhibiting the synthesis of deoxythymidine monophosphate (dTMP).  The downstream effect is promotion of cell death because cells would not be able to properly undergo DNA synthesis if they are lacking dTMP, a necessary precursor to dTTP.
Five agents were in clinical trials in 2002: raltitrexed, pemetrexed, nolatrexed, Plevitrexed( ZD9331/BGC9331), and GS7904L.

Examples include

Raltitrexed, used for colorectal cancer since 1998

Fluorouracil, used for colorectal cancer

BGC 945/ ONX-0801

OSI-7904L

CB300638
Jian ware
Jian ware or Chien ware (Chinese: 建窯; pinyin: Jiàn yáo; Wade–Giles: Chien-yao) is a type of Chinese pottery originally made in Jianyang, Fujian province. It, and local imitations of it, are known in Japan as Tenmoku (天目). It consists of simple shapes in stoneware, with a strong emphasis on subtle effects in the glazes.  In the Song dynasty they achieved a high prestige, especially among Buddhist monks and in relation to tea-drinking.  They were also highly valued in Japan, where many of the best examples were collected.  Though the ceramic body is light-coloured, the wares, generally small cups for tea, bowls and vases, normally are glazed in dark colours, with special effects such as the "hare's fur" "oil-spot" and "partridge feather" patterns caused randomly as excess iron in the glaze is forced out during firing.

Wuyishan, Fujian
Wuyishan City (Chinese: 武夷山市; pinyin: Wǔyíshān Shì) is a county-level city in the municipal region of Nanping, in the northwest of Fujian, People's Republic of China, which borders Jiangxi to the northwest. It corresponds to the former Chong'an County.
New Market–Linvale–Snydertown Historic District
The New Market–Linvale–Snydertown Historic District is a 160-acre (65 ha) historic district located along NJ 31, Linvale, Snydertown, and Woodsville Roads in the communities of Linvale, formerly known as New Market, and Snydertown in the townships of East Amwell and West Amwell in Hunterdon County, New Jersey, United States. It was added to the National Register of Historic Places on February 12, 1998, for its significance in architecture, commerce, settlement, and community development. The district includes 33 contributing buildings, four contributing structures, and one contributing object.

Snydertown, New Jersey
Snydertown is an unincorporated community located within East Amwell Township in Hunterdon County, in the U.S. state of New Jersey. The settlement is located on the southern face of Sourland Mountain at the intersection of Linvale Road and Snydertown Road. In the past, a mill operated in Snydertown.
George Howard, 9th Earl of Carlisle
George James Howard, 9th Earl of Carlisle (12 August 1843 – 16 April 1911), known as George Howard until 1889, was an English aristocrat, peer, politician, and painter. He was the last Earl of Carlisle to own Castle Howard.

Rosalind Howard, Countess of Carlisle
Rosalind Frances Howard, Countess of Carlisle (née Stanley; 20 February 1845 – 12 August 1921), known as the Radical Countess, was an English aristocrat and activist for women's political rights and temperance movement. She was a member of the Stanley and Howard families.
Grand Prix of Portland
The Grand Prix of Portland (known as the BitNile.com Grand Prix of Portland presented by askROI for sponsorship reasons) is a race in the IndyCar Series held at the Portland International Raceway in Portland, Oregon. The race was an annual event from 1984 to 2007, initially as a race in the CART series, and later as part of the Champ Car World Series. After a ten-year hiatus, the race made its return to the IndyCar Series in the 2018 season.

Álex Palou
Álex Palou Montalbo (Catalan pronunciation: [ˈaləks ˈpalɔw monˈtalbu]; born 1 April 1997) is a Spanish racing driver who drives for Chip Ganassi Racing in the IndyCar Series, where he won the 2021, 2023, 2024, and 2025 championships and the 2025 Indianapolis 500. He is the first Spanish racing driver to win a national championship in American open-wheel racing history and also the first Spaniard to win in the GP3 Series and the Indianapolis 500.
Homesite of John O. Meusebach
The Homesite of John O. Meusebach is located at Loyal Valley in Mason County, Texas, 21 miles (34 km) north of Fredericksburg and 18 miles (29 km) southeast of the city of Mason, on U.S. Highway 87 to right-of-way at the intersection of US 87 and RM 2242. Meusebach moved to the property in 1869, after a tornado destroyed his family home in Comal County.

Meusebach was born in Dillenburg, Duchy of Nassau. He had a background in botany, and was educated and trained as a lawyer. As Commissioner-General of the Adelsverein, he founded the city of Fredericksburg, and opened up the Fisher–Miller Land Grant territory to settlement when he brokered the Meusebach–Comanche Treaty. He later served as Texas State Senator District 22. His Loyal Valley homesite was designated a Recorded Texas Historic Landmark in 1969, Marker number 11288.

Mason County, Texas
Mason County is a rural county located on the Edwards Plateau in the U.S. state of Texas. At the 2020 census, its population was 3,953. Its county seat is Mason. The county is named for Fort Mason, which was located in the county.
Beinn Eighe
Beinn Eighe (Scottish Gaelic for 'file mountain') is a mountain massif in the Torridon area of Wester Ross in the Northwest Highlands of Scotland. Lying south of Loch Maree, it forms a long ridge with many spurs and summits, two of which are classified as Munros: Ruadh-stac Mòr at 1,010 m (3,314 ft) and Spidean Coire nan Clach at 993 m (3,258 ft). Unlike most other hills in the area it has a cap of Cambrian basal quartzite which gives the peaks of Beinn Eighe a distinctive light colour. Its complex topography has made it popular with both hillwalkers and climbers and the national nature reserve on its northern side makes it an accessible mountain for all visitors.

Torridon
Torridon (Scottish Gaelic: Toirbheartan) is a small village in the Northwest Highlands of Scotland. The name is also applied to the area surrounding the village, particularly the Torridon Hills, mountains to the north of Glen Torridon. The village lies on the shore of Loch Torridon.
CSM Vaslui (football)
Clubul Sportiv Municipal Vaslui, commonly known as CSM Vaslui, or simply as Vaslui, is a Romanian football team based in Vaslui, Vaslui County, currently playing in the Liga III. The team represents the football section of the multi-sport club CSM Vaslui, which also include basketball, athletics and handball sections.

2022–23 Liga IV
The 2022–23 Liga IV was the 81st season of Liga IV and the 55th since the 1968 administrative and territorial reorganization of the country, representing the fourth tier of the Romanian football league system. The champions of each county association played against one from a neighbouring county in a play-off for promotion to Liga III.

The counties were divided into seven regions, each consisting of six counties and the draw was made on 2 February 2023.
Twisleton-Wykeham-Fiennes family
The Twisleton-Wykeham-Fiennes family (/ˈwɪkəm ˈfaɪnz/) are the descendants of the 16th Baron Saye and Sele who was born Frederick Benjamin Twisleton and adopted the surname Twisleton-Wykeham-Fiennes in 1849 by Act of Parliament. He was the grandson of Thomas Twisleton, 13th Baron Saye and Sele and inherited the barony from his first cousin William Thomas Eardley-Twisleton-Fiennes in 1847. The surname is frequently shortened to Fiennes. Members of the family include the explorer Ranulph Fiennes and the actors Ralph Fiennes, Joseph Fiennes, and Hero Fiennes Tiffin.

Ranulph Fiennes
Sir Ranulph Twisleton-Wykeham-Fiennes, 3rd Baronet OBE (born 7 March 1944), commonly known as Sir Ranulph Fiennes (/ˈrænʌlf ˈfaɪnz/) and sometimes as Ran Fiennes, is an English explorer, writer and poet, who holds several endurance records.

Fiennes served in the British Army for eight years, including a period on counter-insurgency service while attached to the Army of the Sultanate of Oman. He later undertook numerous expeditions and was the first person to visit both the North Pole and South Pole by surface means and the first to completely cross Antarctica on foot. In May 2009, at the age of 65, he reached the summit of Mount Everest.

Guinness Book of Records founding editor Norris McWhirter in 1984 named Fiennes as the greatest living explorer. Fiennes has written numerous books about his army service and his expeditions as well as books on explorers Robert Falcon Scott and Ernest Shackleton.
Danuria
Danuria is a genus of African praying mantids in the family Deroplatyidae.

Males are mesopterous and measure 50–90 mm (2.0–3.5 in) in length. Females are micropterous and measure 61–100 mm (2.4–3.9 in) in length.

Deroplatyidae
The Deroplatyidae are a new (2019) family of praying mantises, based on the type genus Deroplatys.  As part of a major revision of mantis taxonomy, the subfamily Deroplatyinae has been moved here from the previously structured family Mantidae.

The new placement is in superfamily Mantoidea (of group Cernomantodea) and infraorder Schizomantodea.  Genera in this family have been recorded from: Africa, India, Indochina and Malesia.
Violence and the Sacred
Violence and the Sacred (French: La violence et le sacré) is a 1972 book about the sacred by the French critic René Girard, in which the author explores the ritual role of sacrifice. The book received both positive reviews, which praised Girard's theory of the sacred, and more mixed assessments. Some commentators have seen the book as a work that expresses or points toward a Christian religious perspective. However, the book has also been seen as "atheistic" or "hostile to religion". Violence and the Sacred became highly influential, in anthropology, literary criticism, and even Christology. It has been compared to the classicist Walter Burkert's Homo Necans (1972). Girard further developed its ideas in a subsequent book, Things Hidden Since the Foundation of the World (1978).

Homo Necans
Homo Necans: The Anthropology of Ancient Greek Sacrificial Ritual and Myth (German: Homo Necans: Interpretationen Altgriechischer Opferriten und Mythen) is a 1972 book on ancient Greek religion and mythology by the classicist Walter Burkert. It won the Weaver Award for Scholarly Literature, awarded by the Ingersoll Foundation, in 1992.
Brington, Northamptonshire
Brington is a civil parish in West Northamptonshire in England. At the time of the 2001 census, the parish population was 482 people, increasing to 496 at the 2011 census.

It contains three villages:

Great Brington

Little Brington

Nobottle

The name 'Brington' means 'Farm/settlement connected with Bryni'.

West Northamptonshire
West Northamptonshire is one of two unitary authority areas in the ceremonial county of Northamptonshire, England. It contains the county town of Northampton, as well as the towns of Daventry, Brackley and Towcester, and the large villages of Brixworth and Long Buckby; the rest of the area is predominantly agricultural villages though it has many lakes and small woodlands.

West Northamptonshire was created in 2021 as part of local government restructuring from the previous non-metropolitan districts of Northampton, Daventry and South Northamptonshire.

The West Coast Main Line and the M1 and M40 motorways pass through the district, and it includes the site of the Roman town of Bannaventa and the grade I listed Althorp House and its estate.
Mohn und Gedächtnis
Mohn und Gedächtnis is a 1952 German-language poetry collection by Paul Celan. It has been translated into English by Michael Hamburger as Poppy and Memory. It includes Todesfuge (Deathfugue), one of his best-known and often-anthologized poems.

Todesfuge
"Todesfuge" (Deathfugue) is a German language poem written by the Romanian-born poet Paul Celan probably around 1945 and first published in 1948. It is one of his best-known and often-anthologized poems. Despite critics claiming that the lyrical finesse and aesthetic of the poem did not do justice to the cruelty of the Holocaust, others regard the poem as one that "combines mysteriously compelling imagery with rhythmic variations and structural patterns that are both elusive and pronounced". At the same time it has been regarded as a "masterful description of horror and death in a concentration camp". Celan was born to a Jewish family in Cernăuți, Romania (now Chernivtsi, Ukraine); his parents were murdered in the Holocaust, and Celan himself was a prisoner for a time in a work camp. The poem has reached international relevance by being considered to be one of the most important poems of the post-war period and the most relevant example of Trümmerliteratur.
Doreso
Doreso is an automatic content recognition (ACR) company specialized in music discovery and social TV recognition service for the second screen. Their sound-to-sound music search engine allows users to obtain more detailed information about music and songs by singing, humming or by recording original music.

Audio search engine
An audio search engine is a web-based search engine which crawls the web for audio content. The information can consist of web pages, images, audio files, or another type of document. Various techniques exist for research on these engines.
Lions at the Dvortsovaya pier
59°56′23″N 30°18′32″E﻿ / ﻿59.93972°N 30.30889°E﻿ / 59.93972; 30.30889

The Lions at the Dvortsovaya pier are two lion sculptures in bronze placed at the Admiralty embankment in Saint Petersburg since 1832. The lions are copies of the late 16th century Italian Medici lions in Florence.

The lions are the best known among several Medici lions and other lion sculptures in Saint Petersburg. The sculptures were created by the German craftsman, Johan Gottlieb Prang to designs by sculptor Ivan Prokofiev.

Medici lions
The Medici lions are a pair of marble sculptures of lions: one of which is Roman, dating to the 2nd century AD, and the other a 16th-century pendant. By 1598 both were placed at the Villa Medici, Rome.  Since 1789 they have been displayed at the Loggia dei Lanzi in Florence. The sculptures depict standing male lions with a sphere or ball under one paw, looking to the side.

Copies of the Medici lions have been made and publicly installed in over 30 other locations, and smaller versions made in a variety of media. Medici lion has become a term for this sculptural type.

A similar Roman lion sculpture, of the 1st century AD, is known as the Albani lion, and is now in the Louvre.  Here, the stone used for the ball is different from the basalt body. Both may derive from a Hellenistic original.
1st Annual Grammy Awards
The 1st Annual Grammy Awards, which began as The Gramophone Awards, were held on May 4, 1959. They recognized musical accomplishments by performers for the year 1958. Two separate ceremonies were held simultaneously on the same day: one in the Beverly Hilton Hotel in Beverly Hills, California, and the other in the Park Sheraton Hotel in New York City. Ella Fitzgerald, Count Basie, Domenico Modugno, Ross Bagdasarian, and Henry Mancini, each won 2 awards.

Frank Sinatra Sings for Only the Lonely
Frank Sinatra Sings for Only the Lonely (also known as Sings for Only the Lonely or simply Only the Lonely) is the fifteenth studio album by American singer Frank Sinatra. It was released on September 8, 1958, through Capitol Records.

The album consists of a collection of torch songs, following a formula similar to Sinatra's previous albums In the Wee Small Hours (1955) and Where Are You? (1957).

According to John Rockwell's book, Sinatra: An American Classic, when asked at a party in the mid-1970s if he had a favorite album among his recordings, without hesitation, Sinatra chose Only the Lonely.

The album's front cover was painted by Nicholas Volpe, who won a Grammy Award for the painting. The painting features Sinatra as a sullen, Pagliacci-like clown. Sketched on the album's back cover is one of Sinatra's recurrent visual motifs: a lamppost.
Kaniadakis Weibull distribution
The Kaniadakis Weibull distribution (or κ-Weibull distribution) is a probability distribution arising as a generalization of the Weibull distribution. It is one example of a Kaniadakis κ-distribution. The κ-Weibull distribution has been adopted successfully for describing a wide variety of complex systems in seismology, economy, epidemiology, among many others.

Kaniadakis statistics
Kaniadakis statistics (also known as κ-statistics) is a generalization of Boltzmann–Gibbs statistical mechanics, based on a relativistic generalization of the classical  Boltzmann–Gibbs–Shannon entropy (commonly referred to as Kaniadakis entropy or κ-entropy). Introduced by the Greek Italian physicist Giorgio Kaniadakis in 2001, κ-statistical mechanics preserve the main features of ordinary statistical mechanics and have attracted the interest of many researchers in recent years. The κ-distribution is currently considered one of the most viable candidates for explaining complex physical, natural or artificial systems involving power-law tailed statistical distributions. Kaniadakis statistics have been adopted successfully in the description of a variety of systems in the fields of cosmology, astrophysics, condensed matter, quantum physics, seismology, genomics, economics, epidemiology, and many others.
Syro-Malankara Catholic Eparchy of Marthandom
The Eparchy of Marthandom (also called Marthandam) is a Syro-Malankara Catholic Church ecclesiastical territory or eparchy in Kanyakumari District, Tamil Nadu, India. It was created by Pope John Paul II on 16 December 1996. It was the fourth eparchy of the Syro-Malankara Catholic Church. Its territory covers three civil districts: Kaliakkavilai, Marthandam, Nagercoil. The Syro-Malankara Catholic Church in Kanyakumari District is among the largest religious groups in the region. The Eparchy of Marthandam is a suffragan eparchy in the ecclesiastical province of the Archeparchy of Trivandrum.

Christianity in Kanyakumari district
Christianity in Kanyakumari district is the largest religion in the district. The Catholic Church has about 500,000 followers, while the Protestant groups have about 400,000 members.

Christianity is said to date back to the 1st century CE. According to the tradition, St. Thomas, one of the twelve apostles, landed on the Malabar Coast (Kerala) in 52 CE and introduced Christianity. It is believed he built St. Mary's Church in Thiruvithamcode in 63 CE. During the colonial period Italian, British, Dutch and Portuguese Christians came to Tamil Nadu.

In 1961, Christians comprised nearly 37% of the population. In 2011, the Christian population of Kanyakumari is nearly 47% of the population.
Flag of Fiji
The national flag of Fiji was adopted on 10 October 1970. The state arms have been slightly modified but the flag has remained the same as during Fiji's colonial period. It is a defaced cyan "Blue Ensign" (the actual Blue Ensign version of the flag is the government ensign), with the shield from the national coat of arms. It has remained unchanged since Fiji was declared a republic in 1987, despite calls from some politicians for changes.

A plan to change the flag, announced by Prime Minister Frank Bainimarama in 2013, was abandoned in August 2016.

National flag
A national flag is a flag that represents and symbolizes a given nation. It is flown by the government of that nation, but can also be flown by its citizens. A national flag is typically designed with specific meanings for its colors and symbols, which may also be used separately from the flag as a symbol of the nation. The design of a national flag is sometimes altered after the occurrence of important historical events.
Jason Boesel
Jason Lyon Boesel (born August 17, 1977) is an American musician, songwriter and producer based in Los Angeles. He was the drummer for Rilo Kiley and has also played with The Elected and Conor Oberst and the Mystic Valley Band.

Evergreen (American band)
Evergreen was a Southern California underground post-hardcore band from the early-to-mid-1990s. They were influential in the development of emo in the 1990s.

They had several releases over their lifespan, including two 7-inches, a split 7-inch with Los Angeles hardcore/screamo band Still Life, and a much sought-after 12-inch, most of which were released on Anomaly Records. They still have a 7-inch out on San Diego's Gravity Records. They are notorious amongst record collectors due to the rarity of the "Seven Songs" LP.

Band members were Aaron Calvert on guitar and vocals, Andy Ward on bass (also of Antioch Arrow), and Jason Boesel on drums (now in Rilo Kiley and Phases).
Agnes of Meissen
Agnes of Meissen (born before 1264 – died after September 1332) was a noblewoman, the daughter of Albert II, Margrave of Meissen and his wife Margaret of Sicily.

Agnes was married with Henry I "the Marvelous" of Brunswick-Grubenhagen, in 1282. They had 16 children:

Elizabeth (born c. 1282), married Frederick, Count of Beichlingen

Otto (born c. 1283, died in or before 1309)

Albert (born c. 1284, died after 1341), joined the Teutonic Order

Adelaide (1285–1320), married King Henry I of Bohemia

Facie (daughter; born c. 1286, died before or in 1312)

Agnes, Abbess of Osterode

Henry II, Duke of Brunswick-Lüneburg

Frederick

Adelheid of Brunswick, married to Andronikos III Palaiologos

Conrad (c. 1294 – c. 1320)

Mechtild (c. 1295 – 14 March 1344), married John II of Werle

Ernest I, Duke of Brunswick-Grubenhagen

William, Duke of Brunswick-Grubenhagen

Richardis, Abbess of Osterode

Margaret (born c. 1300, died in or after 1312)

John I, Duke of Brunswick-Grubenhagen

Margaret of Sicily
Margaret of Sicily, also called Margaret of Hohenstaufen or Margaret of Germany (Italian: Margherita di Sicilia; German: Margaretha von Staufen; 1 December 1241 – 8 August 1270) was a Sicilian and German princess from the House of Hohenstaufen. By marriage she became Landgravine of Thuringia and Countess Palatine of Saxony (Landgräfin von Thüringen und Pfalzgräfin von Sachsen).

She was born in Foggia, the daughter of Frederick II, Holy Roman Emperor, King of Sicily and Germany, and his third wife, Isabella of England. Her paternal grandparents were Henry VI, Holy Roman Emperor and Constance of Sicily. Her maternal grandparents were John of England and Isabella of Angoulême.
Norma Torres
Norma Judith Torres (née Barillas;  born April 4, 1965) is an American politician. She is a member of the United States House of Representatives for California's 35th congressional district. Previously, she was a member of the California State Senate representing the 32nd district. She is a member of the Democratic Party.

Pomona, California
Pomona (/pəˈmoʊnə/ ⓘ pə-MOH-nə) is a city in eastern Los Angeles County, California, United States. Pomona is located in the Pomona Valley, between the Inland Empire and the San Gabriel Valley. At the 2020 census, the city's population was 151,713. The main campus of California State Polytechnic University, Pomona, also known as Cal Poly Pomona, lies partially within Pomona's city limits, with the rest being located in the neighboring unincorporated community of Ramona.