hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Proprotein convertase
Proprotein convertases (PPCs) are a family of proteins that activate other proteins. Many proteins are inactive when they are first synthesized, because they contain chains of amino acids that block their activity. Proprotein convertases remove those chains and activate the protein. The prototypical proprotein convertase is furin. Proprotein convertases have medical significance, because they are involved in many important biological processes, such as cholesterol synthesis. Compounds called proprotein convertase inhibitors can block their action, and block the target proteins from becoming active. Many proprotein convertases, especially furin and PACE4, are involved in pathological processes such as viral infection, inflammation, hypercholesterolemia, and cancer, and have been postulated as therapeutic targets for some of these diseases.

Furin
Furin is a protease, a proteolytic enzyme activated by substrate presentation that in humans and other animals is encoded by the FURIN gene. Some proteins are inactive when they are first synthesized, and must have sections removed in order to become active. Furin cleaves these sections and activates the proteins. It was named furin because it was in the upstream region of an oncogene known as FES. The gene was known as FUR (FES Upstream Region) and therefore the protein was named furin. Furin is also known as PACE (Paired basic Amino acid Cleaving Enzyme). A member of family S8, furin is a subtilisin-like peptidase.
Stuart Dew
Stuart Dew (born 18 August 1979) is an Australian rules football coach and former head coach of the Gold Coast Suns in the Australian Football League (AFL). He is currently an assistant coach at the Port Adelaide Football Club. As a player, he played for Port Adelaide and Hawthorn, winning premierships for both clubs in 2004 and 2008 respectively. Dew was acknowledged as being a long penetrating left foot kick of the football.

2008 AFL Grand Final
The 2008 AFL Grand Final was an Australian rules football match contested between the Geelong Football Club and the Hawthorn Football Club, held at the Melbourne Cricket Ground in Melbourne on 27 September 2008. It was the 112th annual grand final of the Australian Football League (formerly the Victorian Football League), staged to determine the Premiers for the 2008 AFL season. The match, attended by 100,012 spectators, was won by Hawthorn by a margin of 26 points, marking that club's tenth premiership overall and first since 1991. Hawthorn's Luke Hodge was awarded the Norm Smith Medal as the best player on the ground.
Târnava Mare
The Târnava Mare ("Great Târnava"; Hungarian: Nagy-Küküllő; German: Große Kokel) is a river in Romania. Its total length is 223 km (139 mi) and its basin size is 3,666 km2 (1,415 sq mi). Its source is in the Eastern Carpathian Mountains, near the sources of the Mureș and Olt in Harghita County. It flows through the Romanian counties of Harghita, Mureș, Sibiu, and Alba. The cities of Odorheiu Secuiesc, Sighișoara, and Mediaș lie on the Târnava Mare. It joins the Târnava Mică in Blaj, forming the Târnava.

Sighișoara
Sighișoara (Romanian pronunciation: [siɡiˈʃo̯ara] ⓘ; Hungarian: Segesvár [ˈʃɛɡɛʃvaːr] ⓘ; German: Schäßburg [ˈʃɛsbʊʁk]; Transylvanian Saxon: Schäsbrich, Šesburχ, or Scheeßprich; Yiddish: שעסבורג, romanized: Shesburg; Latin: Castrum Sex or Saxoburgum) is a city on the Târnava Mare River in Mureș County, central Romania. Located in the historic region of Transylvania, Sighișoara had a population of 23,927 according to the 2021 census. It is a popular tourist destination for its well-preserved old town, which is listed by UNESCO as a World Heritage Site since 1999. The town administers seven villages: Angofa, Aurel Vlaicu, Hetiur, Rora, Șoromiclea, Venchi, and Viilor.
25C-NBOH
25C-NBOH (2C-C-NBOH, NBOH-2CC) is a psychedelic drug and derivative of the phenethylamine derived hallucinogen 2C-C. It has similar serotonin receptor affinity to the better-known compound 25C-NBOMe. The drug has been encountered as a novel designer drug.

25I-NBOH
25I-NBOH (NBOH-2C-I, Cimbi-27, 2C-I-NBOH) is a derivative of the phenethylamine-derived hallucinogen 2C-I that was discovered in 2006 by a team at Purdue University. It is a known metabolite of 25I-NBOMe and has also been encountered as a novel designer drug.
Fred Young (director)
Fred Young (born Njo Tiong Gie; Chinese: 楊中義; pinyin: Yáng Zhōngyì; 31 October 1900 – 2 June 1977) was an ethnic Chinese film director and producer active in the Dutch East Indies and its successor state, Indonesia. He reportedly studied film in Hollywood as a youth, but only entered the nation's film industry in 1940. After he made his debut as a writer with Sorga Palsoe, he was involved in some 36 productions, 23 as director.

Sorga Palsoe
Sorga Palsoe ([ˈsɔrɡa ˈpalsu]; Indonesian for False Heaven) is a 1941 film from the Dutch East Indies (present-day Indonesia) which was directed by Tan Tjoei Hock for Java Industrial Film. The tragedy, starring Lo Tjin Nio, Tong Hui, Lim Poen Tjiaw, and Rohana, was a commercial failure. It is likely lost.
Catman (DC Comics)
Catman (Thomas Reese Blake) is a character appearing in American comic books published by DC Comics. He is part of Batman's growing roster of enemies, debuting in the mid-1960s.

For decades, the character rarely appeared in comic books, as Batman stories returned to darker themes. A modern revival of the character in the pages of Green Arrow many years later depicted a Catman down on his luck, clinging to past glories, overweight, and pathetic.

In 2006, however, the character was rehabilitated by writer Gail Simone, depicting Blake as having picked himself up from the gutter, restoring his physical fitness and gaining a new sense of purpose and dignity while living with lions in Africa. Stories since then have depicted him as an antihero and the leader of the mercenary team Secret Six.

Gail Simone
Gail Simone (born July 29, 1974) is an American writer best known for her work in comics on DC's Birds of Prey, Batgirl, Dynamite Entertainment's Red Sonja, and for being the longest running female writer on Wonder Woman to date. Other notable works include Clean Room, Secret Six, Welcome to Tranquility, The All-New Atom, and Deadpool.

She enjoyed a long-running stint on The Simpsons comics and has also written for television and video games. In 2024, Orbit Books published her debut novel Red Sonja: Consumed.

Her work has been nominated for a number of awards including the GLAAD Media Award, and she is the recipient of an Inkpot Award at the 2017 San Diego Comic-Con.
Matt Besser
Matthew Gregory Besser (born September 22, 1967) is an American actor, comedian, director, producer, writer, and one of the four founding members of the Upright Citizens Brigade sketch comedy troupe, who had their own show on Comedy Central from 1998 to 2000. He hosts the improvisation-based podcast Improv4humans, previously on the Earwolf network, but now solely operated by himself and Brett Morris.

Adam McKay
Adam McKay (born April 17, 1968) is an American screenwriter, producer, and director. McKay began his career as a head writer for the NBC sketch comedy show Saturday Night Live (SNL) from 1995 to 2001. After leaving SNL, McKay collaborated with comedian Will Ferrell on his comedy films Anchorman: The Legend of Ron Burgundy (2004), Talladega Nights: The Ballad of Ricky Bobby (2006), and The Other Guys (2010). Ferrell and McKay  co-wrote and co-produced many television series and films, with McKay himself co-producing their website Funny or Die through their company, Gary Sanchez Productions.

Aside from working with Ferrell, McKay wrote and directed the satirical films The Big Short (2015), Vice (2018), and Don't Look Up (2021). He won an Academy Award, a BAFTA, and a Critics' Choice Award for adapting the screenplay of The Big Short. In 2019, McKay founded the production company Hyperobject Industries.
Gaetana
Gaetana is the debut album by Italian pop singer Giusy Ferreri,
it was released on November 14, 2008, in Italy, and digitally in many other European countries. Four singles were released from the album: "Non ti scordar mai di me", "Novembre", "Stai fermo lì" and "La scala (The Ladder)". Gaetana has sold around 500,000 copies only in Italy being certified 6 times platinum and around 600,000 copies worldwide.

Stai fermo lì
"Stai fermo lì" is a song by Italian pop  singer Giusy Ferreri, released as third single from her debut album Gaetana. The song was written and produced by Italian Pop-R&B singer Tiziano Ferro.
It was released digitally in Italy and Switzerland on 16 January 2008.
Angus (film)
Angus is a 1995 coming-of-age comedy film directed by Patrick Read Johnson.  The film stars George C. Scott, Chris Owen, Ariana Richards, Anna Thomson, Charlie Talbert in his film debut as the eponymous character, and Kathy Bates. Angus is based on the short story "A Brief Moment in the Life of Angus Bethune" by Chris Crutcher, from his collection Athletic Shorts: Six Short Stories.

It is mostly filmed in Owatonna, Minnesota at Owatonna Senior High School.

Ariana Richards
Ariana Clarice Richards (born September 11, 1979) is an American painter and former actress. She is best known for her role as Lex Murphy in the 1993 film Jurassic Park. Richards won several Young Artist Awards for her acting as a child, but as an adult has focused primarily on her art career.
Ushite
Ushite (Bulgarian: Ушите [oˈʃitɛ]) is a 1,978 m peak in the Pirin mountain range, south-western Bulgaria, making it the highest summit in South Pirin. It is situated on the main mountain ridge between the peaks of Sveshtnik (1,975 m) and Mutorok (1,971 m). Ushite is covered with forests. In Bulgarian its name means "the ears" and the etymology is linked with the presence of several rock piles on the summit likened to ears.

Most sources have traditionally referred to Sveshtnik as the highest summit in the southern division of Pirin.

Sveshtnik
Svesthnik (Bulgarian: Свещник) is a 1,975 m peak in the Pirin mountain range, south-western Bulgaria, making it the second highest summit in South Pirin after Ushite (1,978 m). It rises on the main mountain ridge to the south of Popovi Livadi saddle and to the north-west of Ushite. Svesthnik is built up of granite and has a conical shape with rounded steep slopes. Its slopes are covered with forests of Scots pine (Pinus sylvestris) and Norway spruce (Picea abies), while the summit itself is bare, covered with subalpine herbaceous vegetation.

Most sources have traditionally referred to Sveshtnik as the highest summit in the southern division of Pirin.
Gone (Pearl Jam song)
"Gone" is a song by the American rock band Pearl Jam. Written by vocalist Eddie Vedder, "Gone" was released to rock radio on September 4, 2006, as the third single from the band's eighth studio album, Pearl Jam (2006). It became available through digital music retailers on October 7, 2006. The song reached number 40 on the Billboard Modern Rock Tracks chart.

Eddie Vedder
Eddie Jerome Vedder (born Edward Louis Severson III, December 23, 1964) is an American singer, musician, and songwriter. He is the lead vocalist, primary lyricist, and one of three guitarists for the rock band Pearl Jam. He was previously a guest vocalist for supergroup Temple of the Dog, a tribute band dedicated to singer Andrew Wood.

In 2007, Vedder released his first solo album as a soundtrack for the film Into the Wild (2007). His second album, Ukulele Songs, and a live DVD titled Water on the Road were released in 2011. His third solo album Earthling was released in 2022. In late June 2024, Vedder released a single cover of The English Beat's "Save It for Later" for the TV series The Bear.

Vedder, who is known for his baritone vocals, was ranked seventh on a list of "Best Lead Singers of All Time", based on a readers' poll compiled by Rolling Stone. In 2017, Vedder was inducted into the Rock and Roll Hall of Fame as a member of Pearl Jam.
Andrew Phelps McCormick
Andrew Phelps McCormick (December 18, 1832 – November 2, 1916) was a United States circuit judge of the United States Court of Appeals for the Fifth Circuit and of the United States Circuit Courts for the Fifth Circuit and previously was a United States district judge of the United States District Court for the Northern District of Texas.

United States District Court for the Northern District of Texas
The United States District Court for the Northern District of Texas (in case citations, N.D. Tex.) is a United States district court. Its first judge, Andrew Phelps McCormick, was appointed to the court on April 10, 1879. The court convenes in Dallas, Texas, with divisions in Fort Worth, Amarillo, Abilene, Lubbock, San Angelo, and Wichita Falls. It has jurisdiction over 100 counties in the northern and central parts of the U.S. state of Texas.

The United States Attorney's Office for the Northern District of Texas represents the United States in civil and criminal litigation in the court. As of May 29, 2025, the acting United States Attorney is Nancy Larson.

Appeals from this court are heard by the U.S. Court of Appeals for the Fifth Circuit, which includes Louisiana, Mississippi and Texas (except for patent claims and claims against the U.S. government under the Tucker Act, which are appealed to the Federal Circuit).
Archdiocese of Miami
The Archdiocese of Miami (Latin: Archidioecesis Miamiensis, Spanish: Arquidiócesis de Miami, Haitian Creole: Achidyosèz Miami) is an archdiocese of the Catholic Church in South Florida in the United States. Formed in 1958, it is the metropolitan see for the Ecclesiastical Province of Miami, which covers all of Florida. The Archdiocese of Miami contains the Florida counties Broward, Miami-Dade and Monroe. The Cathedral of Saint Mary is the mother church of the archdiocese. The archbishop is Thomas Wenski.

John Favalora
John Clement Favalora (born December 5, 1935) is an American prelate of the Catholic Church. He served as archbishop of the Archdiocese of Miami from 1994 to 2010, as bishop of the Diocese of Alexandria in Louisiana from 1986 to 1989 and as bishop of the Diocese of St. Petersburg in Florida from 1989 to 1994.
Jon Hendricks
John Carl Hendricks (September 16, 1921 – November 22, 2017), known professionally as Jon Hendricks, was an American jazz lyricist and singer. He is one of the originators of vocalese, which adds lyrics to existing instrumental songs and replaces many instruments with vocalists, such as the big-band arrangements of Duke Ellington and Count Basie. He is considered one of the best practitioners of scat singing, which involves vocal jazz soloing. Jazz critic and historian Leonard Feather called him the "Poet Laureate of Jazz", while Time dubbed him the "James Joyce of Jive". Al Jarreau called him "pound-for-pound the best jazz singer on the planet—maybe that's ever been".

Kurt Elling
Kurt Elling (born November 2, 1967) is an American jazz singer and songwriter.

Born in Chicago, Illinois, and raised in Rockford, Elling became interested in music through his father, who was Kapellmeister at a Lutheran church.  He sang in choirs and played musical instruments. He encountered jazz while a student at Gustavus Adolphus College in Minnesota. After college, he enrolled in the University of Chicago Divinity School, but he left one credit short of a degree to pursue a career as a jazz vocalist.

Elling began to perform around Chicago, scat singing and improvising his lyrics.  He recorded a demo in the early 1990s and was signed by Blue Note. He has been nominated for seventeen Grammy Awards, winning Best Vocal Jazz Album for Dedicated to You (2009) and Secrets Are the Best Stories (2021).  Elling often leads the Down Beat magazine Critics' Poll. He had a longtime collaboration with pianist Laurence Hobgood, leading a quartet that toured throughout the world.
The Big House (1930 film)
The Big House is a 1930 American pre-Code  prison drama film directed by George Hill, released by Metro-Goldwyn-Mayer, and starring Chester Morris, Wallace Beery, Lewis Stone and Robert Montgomery. The story and dialogue were written by Frances Marion, who won the Academy Award for Best Writing Achievement. As one of the first prison movies, it inspired many others of this genre.

Wallace Beery
Wallace Fitzgerald Beery (April 1, 1885 – April 15, 1949) was an American film and stage actor. He is best known for his portrayal of Bill in Min and Bill (1930) opposite Marie Dressler, as General Director Preysing in Grand Hotel (1932), as the pirate Long John Silver in Treasure Island (1934), as Pancho Villa in Viva Villa! (1934) for which he won the Volpi Cup for Best Actor, and his title role in The Champ (1931), for which he won the Academy Award for Best Actor. Beery appeared in some 250 films during a 36-year career. His contract with Metro-Goldwyn-Mayer stipulated in 1932 that he would be paid $1 more than any other contract player at the studio. This made Beery the highest-paid film actor in the world during the early 1930s. He was the brother of actor Noah Beery and uncle of actor Noah Beery Jr.

For his contributions to the film industry, Beery was posthumously inducted into the Hollywood Walk of Fame in 1960.
Norton Children's Hospital
Norton Children's Hospital, formerly Kosair Children's Hospital, for the Kosair Charities, is a pediatric acute care children's hospital located in Louisville, Kentucky and affiliated with the University of Louisville School of Medicine. The hospital has 300 pediatric beds, providing comprehensive pediatric specialties and subspecialties to infants, children, teens, young adults, age 0-21 throughout Kentucky and the surrounding states. Established in 1892 as Children's Free Hospital, it is part of Norton Healthcare. Norton Children's Hospital also features the region's only Level 1 Pediatric Trauma Center and Level IV Neonatal Intensive Care Unit. In 2016, actress Jennifer Lawrence, a Louisville native, donated $2 million to the Norton Children's Hospital in Louisville to set up a cardiac intensive care unit (CICU) named after her foundation.

Norton Healthcare
Norton Healthcare is a Kentucky healthcare system with more than 40 clinics and hospitals in and around Louisville, Kentucky. The hospital and health care system is the Louisville area's second-largest private employer, located at more than 140 locations throughout Greater Louisville, and Southern Indiana. The Louisville-based system includes six hospitals, one being in Madison, Indiana, (with ongoing expansion into Southern Indiana), and with 1,993 licensed beds, eight outpatient centers, 18 Norton Immediate Care Centers, over 14,500 employees, over 1,500 employed medical providers, and approximately 2,000 total physicians on its medical staff.
Meenakshi
Meenakshi also spelled as Minakshi or Mīnāṭci, and also known as Aṅgayaṟkaṇṇi, and Taḍādakai, is a Hindu goddess. She is considered as a form of the goddess Parvati, and is the tutelary deity of Madurai. Along with Kamakshi, and Visalakshi, she is considered as one of the three avatars of Adi Shakti: Vishalakshi in the north, She is represented as the divine consort of Sundaresvarar, a form of Shiva, and the sister of Alagar, a form of Vishnu.

Meenakshi finds mention in Tamil literature as the warrior queen of the ancient Pandya kingdom, and was later deified. She is mainly worshiped in South India, and has a major temple devoted to her in Madurai. Her iconography is usually represented with a raised right hand holding a lotus, on which sits a green parrot, while her left hand hangs by her side. Meenakshi Tirukalyanam, the marriage of Meenakshi and Shiva is celebrated as a major festival. She was also extolled as Shri Vidya by Adi Shankara.

Vishalakshi Temple
The Vishalakshi Temple, also known as Vishalakshi Gauri Mandir and Vishalakshi Amman Kovil. It is one of the famous Hindu temple at Varanasi. Dedicated to the goddess Vishalakshi (an aspect of the goddess Parvati). It was built and is maintained since the 19th century by the Nattukottai Nagarathars, a mercantile community from Tamil Nadu

It is generally regarded as a Shakti Pitha, the most sacred temples dedicated to the Hindu Divine Mother. The earrings of the goddess Sati were said to have fallen on this holy spot of Varanasi. Vishalakshi Temple is known for its temple festival on Kajali Tij, held on the third day during waning fortnight in the Hindu month of Bhadrapada (August).
Gerhard Grimmer
Gerhard Grimmer (6 April 1943 – 9 October 2023) was an East German cross-country skier who competed during the 1960s and 1970s. He won several medals at the FIS Nordic World Ski Championships, including golds in the 50 km and the 4 × 10 km relay (both in 1974); silvers in the 30 km (1970), 4 × 10 km relay (1970), and 15 km (1974); and a bronze in the 50 km (1970). Grimmer also won the Holmenkollen ski festival at 50 km twice (1970–71). He competed at three Olympics (1968, 1972, and 1976) and his best Olympic finish was fifth at the 1976 Winter Olympics in Innsbruck in the 50 km.

In 1975, he was awarded the Holmenkollen medal, sharing it with Oddvar Brå and Ivar Formo.

Grimmer died on 9 October 2023, at the age of 80.

Oddvar Brå
Oddvar Brå (born 16 March 1951) is a Norwegian former cross-country skier. He was among the best skiers in Norway, the three-times winner of the World Cup (1972–73, then named "World ranking", 1974–75 and 1978–79) and the winner of 16 national championships. His success in the major international championships was more modest.
Scott McGillivray
Scott McGillivray (born April 7, 1978) is a Canadian entrepreneur, investor, television host, author and educator.

McGillivray is the host and executive producer of the series Income Property, a home renovation show on HGTV Canada and the DIY Network (Canada); and HGTV and DIY Network in the United States.  He is a judge on HGTV's All American Handyman with Mike Holmes and on Canada's Handyman Challenge along with Mike Holmes, Bryan Baeumler and Paul Lafrance.

Canada's Handyman Challenge
Canada's Handyman Challenge is a Canadian reality game show. The series premiered on January 10, 2012, on HGTV Canada. Canada's Handyman Challenge is the successor to HGTV's previous series, Handyman Superstar Challenge, similar in format to the All American Handyman sister show.
Leisure and Cultural Services Department
The Leisure and Cultural Services Department (LCSD), is a department in the Government of Hong Kong. It reports to the Culture, Sports & Tourism Bureau, headed by the Secretary for Culture, Sports and Tourism. It provides leisure and cultural activities for the people of Hong Kong, which was also one of the tasks of the former Urban Council, and Regional Council and Home Affairs Bureau. It manages various public facilities around Hong Kong including public libraries, swimming pools, sports centres, parks, beaches and waterfront areas. The well-known Hong Kong Cultural Centre and Hong Kong Space Museum are among several museums also managed by the department. It was established in 2000 and its headquarters is in Shatin, New Territories.

Until July 2022, the department was headed by the Secretary for Home Affairs.

Urban Council
The Urban Council (UrbCo) was a municipal council in Hong Kong responsible for municipal services on Hong Kong Island and in Kowloon (including New Kowloon). These services were provided by the council's executive arm, the Urban Services Department. Later, the equivalent body for the New Territories was the Regional Council.

The council was founded as the Sanitary Board in 1883. It was renamed the Urban Council when new legislation was passed in 1936 expanding its mandate. In 1973 the council was reorganised under non-government control and became financially autonomous. Originally composed mainly of ex-officio and appointed members, by the time the Urban Council was disbanded following the Handover it was composed entirely of members elected by universal suffrage.