hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
Integrase
Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates (forms covalent links between) its genetic information into that of the host cell it infects. Retroviral INs are not to be confused with phage integrases (recombinases) used in biotechnology, such as λ phage integrase, as discussed in site-specific recombination.

The macromolecular complex of an IN macromolecule bound to the ends of the viral DNA ends has been referred to as the intasome; IN is a key component in this and the retroviral pre-integration complex.

Pre-integration complex
The pre-integration complex (PIC) is a nucleoprotein complex of viral genetic material and associated viral and host proteins which is capable of inserting a viral genome into a host genome.  The PIC forms after uncoating of a viral particle after entry into the host cell. In the case of the human immunodeficiency virus (HIV), the PIC forms after the Reverse Transcription Complex (RTC) has reverse transcribed the viral RNA into DNA.  The PIC consists of viral proteins (including Vpr, matrix and integrase), host proteins (including Barrier to autointegration factor 1) and the viral DNA.  The PIC enters the cellular nucleus through the nuclear pore complex without disrupting the nuclear envelope, thus allowing HIV and related retroviruses to replicate in non-dividing cells. Following nuclear entry, the PIC's DNA payload may be integrated into the host DNA as a "provirus".
Queen Street, Auckland
Queen Street is the major commercial thoroughfare in the Auckland CBD, Auckland, New Zealand's largest city. The northern end is at Queens Wharf on the Auckland waterfront, adjacent to the Britomart Transport Centre and the Downtown Ferry Terminal. The road is close to straight, the southern end being almost three kilometres away in a south-southwesterly direction on the Karangahape Road ridge, close to the residential suburbs in the interior of the Auckland isthmus.

Auckland Ferry Terminal
The Auckland Ferry Terminal, also called the Downtown Ferry Terminal, is the hub of the Auckland ferry network, which connects the Auckland CBD with suburbs in North Shore, West Auckland, and South Auckland, and islands in the Hauraki Gulf. The terminal is on the Auckland waterfront, at the north end of Queen Street, across Quay Street from the Waitematā railway station, which is the hub for local buses and trains.

The ferry terminal is composed of two main elements, a yellow Edwardian Baroque building facing Queen Street and the CBD, and newer wharves and a waiting area building (the actual ferry terminal of today) facing the Waitematā Harbour.
Najaf
Najaf is the capital city of the eponymous Najaf Governorate in central Iraq, about 160 km (99 mi) south of Baghdad. Its estimated population in 2024 was about 1.41 million people. It is widely considered amongst the holiest cities of Shia Islam and one of its spiritual capitals, as well as the center of Shia political power in Iraq.

It is the burial place of Muhammad's son in law and cousin, ‘Alī ibn Abī Tālib, and thus a major pilgrimage destination for Shia Muslims. The largest cemetery in the world (Wadi-us-Salaam) and the oldest Shi'a Islamic seminary in the world (Hawza of Najaf) are located in Najaf.

Imam Ali Shrine
The Imam Ali Shrine (Arabic: حَرَم ٱلْإِمَام عَلِيّ, romanized: Ḥaram al-ʾImām ʿAlī), also known as the Mosque of Ali (Arabic: مَسْجِد عَلِيّ, romanized: Masjid ʿAlī), is a Shi'ite mosque and shrine, located in Najaf, in the Najaf Governorate of Iraq. The site is a mausoleum which Shia and Sunni Muslims believe contains the tomb of Ali ibn Abi Talib, a cousin, son-in-law and companion of the Islamic prophet Muhammad.

The Shias consider Ali as their first Imam and Muhammad’s rightful successor, while the Sunnis regard him as the fourth Sunni Rashid Caliph. According to Shia belief, buried next to Ali within this mosque are the remains of Adam and Nuh (Noah). Each year, millions of pilgrims visit the shrine and pay tribute to Imam Ali. The shrine has been built and rebuilt numerous times throughout history.
Spirit Warriors (film)
Spirit Warriors (stylized as SPIRI† WARRIORS) is a 2000 Filipino fantasy horror film written and directed by Chito S. Roño. It was followed by a sequel, Spirit Warriors: The Shortcut, which was released on January 1, 2003.

Spirit Warriors: The Shortcut
Spirit Warriors: The Shortcut (also known as Spirit Warriors 2) is a 2003 Filipino fantasy horror adventure film directed by Chito S. Roño, and a sequel to the 2000 film Spirit Warriors. The film was written and directed by Chito S. Roño with screenplay by Roy C. Iglesias. It was distributed by Regal Films.
Uppsala Östra Station
Uppsala Östra station (Uppsala East) is a heritage railway station in Uppsala, Sweden. It was originally located on Storgatan, about 100 meters from Uppsala Central Station. The station served as the western terminus of the Uppsala-Lenna Railway and later the Stockholm-Roslagen Railway, before becoming the main station for the heritage railway Upsala-Lenna Jernväg.

Uppsala Central Station
Uppsala Central Station is a railway station in Uppsala, Sweden. It lies on the East Coast Line, which runs south to Stockholm and north to Gävle and Sundsvall. It is also the southeastern terminus for the Dala Line which runs northwest ending in Mora. There are frequent commuter services to Stockholm. Long-distance trains, such as the SJ 3000, connect Uppsala to the northern parts of the country. Many trains, including the Stockholm commuter rail (Pendeltåg), also leave the main line to connect Uppsala with Stockholm-Arlanda Airport. Next to the station is a hub for the regional coach services operated by Upplands Lokaltrafik. Many local bus routes run through or near the station grounds as well, and there is a large area set aside for bicycle parking.

Located just beside Uppsala Central Station is Uppsala Östra Station (Uppsala East), the western terminus of the Upsala-Lenna Jernväg heritage railway, which was relocated closer to Uppsala C in 2012.
Patisiran
Patisiran, sold under the brand name Onpattro, is a medication used for the treatment of polyneuropathy in people with hereditary transthyretin-mediated amyloidosis, a fatal rare disease that is estimated to affect 50,000 people worldwide.

It is the first small interfering RNA-based drug approved by the U.S. Food and Drug Administration (FDA) and the first drug approved by the FDA to treat this condition. It is a gene silencing drug that interferes with the production of an abnormal form of transthyretin. Patisiran utilizes a novel approach to target and reduce production of the TTR protein in the liver via the RNAi pathway.

Patisiran was developed and is marketed by Alnylam. The FDA considers it to be a first-in-class medication.

Small interfering RNA
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded non-coding RNA molecules, typically 20–24 base pairs in length, similar to microRNA (miRNA), and operating within the RNA interference (RNAi) pathway. It interferes with the expression of specific genes with complementary nucleotide sequences by degrading messenger RNA (mRNA) after transcription, preventing translation. It was discovered in 1998 by Andrew Fire at the Carnegie Institution for Science in Washington, D.C. and Craig Mello at the University of Massachusetts in Worcester.
2020 Korea floods
Between June and August 2020, floods severely impacted large areas of both North and South Korea due to heavy rains of the regional rainy season, primarily in the far southern parts of the Korean Peninsula.  These floods are closely related to ones across China and in Kyushu, Japan. As of 10 August 2020, 32 people have died in South Korea as a result. The Ministry of the Interior and Safety estimated the damage to be ₩1.04 trillion (US$875 million).

2020 Kyushu floods
The 2020 Kyushu floods were a series of floods in July 2020 brought on when record-breaking heavy rain hit the prefectures of Kumamoto and Kagoshima, on the southern Japanese island of Kyushu, on 4 July 2020 in the middle of the East Asian rainy season. The event is officially referred to as Reiwa ni-nen shichi-gatsu gōu (令和２年７月豪雨, "Heavy rain of July, Reiwa 2") by the Japan Meteorological Agency. As a result of flooding and landslides, 77 people were confirmed dead (includes 1 death due to cardiopulmonary arrest) and approximately seven are missing. Fourteen of the victims were residents of an old age home in Kuma, Kumamoto that was flooded. Approximately 15,335 buildings were destroyed, damaged or flooded. Damage was calculated at ¥600 billion (US$5.67 billion).
Pingo Canadian Landmark
Pingo Canadian Landmark, also known as Pingo National Landmark, is a natural area protecting eight pingos near Tuktoyaktuk, Northwest Territories. It is in a coastal region of the Arctic Ocean which contains approximately 1,350 Arctic ice dome hills—approximately one quarter of the world's pingos.

Pingo
Pingos are intrapermafrost ice-cored hills,   3–70 m (10–230 ft) high and 30–1,000 m (98–3,281 ft) in diameter. They are typically conical in shape and grow and persist only in permafrost environments, such as the Arctic and subarctic. A pingo is a periglacial landform, which is defined as a non-glacial landform or process linked to colder climates. It is estimated that there are more than 11,000 pingos on Earth, with the Tuktoyaktuk peninsula area having the greatest concentration at a total of 1,350.
Silja Walter
Silja Walter (born Cécile Walter; 23 April 1919 – 31 January 2011) was a Swiss author and Benedictine nun in the Fahr Abbey. At age 30 she became a nun; her religious name was Maria Hedwig (OSB). Her brother, Otto F. Walter, was also an author.

Otto F. Walter
Otto F. Walter (5 June 1928 born as Otto Friedrich Walter – 24 September 1994) was a Swiss publisher (Walter Verlag), author and novelist, which is well known in the German language countries. Otto Friedrich Walter was the younger brother of Silja Walter, a Benedictine nun in the Fahr Abbey and also a popular writer.
Savo (historical province)
Savo, or Savonia (Finnish: Savo; Swedish: Savolax), is a historical province in the east of Finland. It borders Tavastia, Ostrobothnia and Karelia. Savo is now divided into two provinces: North Savo and South Savo. The largest cities in Savo by population are Kuopio, Mikkeli, Savonlinna, Varkaus and Iisalmi.

North Savo
North Savo (or Northern Savonia; Finnish: Pohjois-Savo; Swedish: Norra Savolax) is a region in eastern Finland. It borders the regions of South Savo, Central Finland, North Ostrobothnia, Kainuu, and North Karelia. Kuopio is the largest city in the region and Lake Kallavesi is the largest lake in the region.

The region's traditional food is a fish and bacon filling pie called Kalakukko.
WVPT
WVPT (channel 51) is a PBS member television station in Staunton, Virginia, United States, serving the Shenandoah Valley of Virginia and West Virginia. It is a full-time satellite of Richmond-licensed WCVE-TV (channel 23) which is owned by the VPM Media Corporation. WVPT's offices are located at Lakeview Hall near the campus of James Madison University on Port Republic Road in Harrisonburg, while its transmitters are located atop Elliott Knob west of Staunton, on Carters Mountain south of Charlottesville, and on Massanutten Mountain near New Market. Master control and most internal operations are based at WCVE-TV's studios at 23 Sesame Street in Bon Air, a suburb of Richmond.

WVPT operates a second station, WVPY, licensed to New Market. WVPY was formerly a full-time satellite of WVPT which served Winchester and the upper Shenandoah Valley. Through a channel-sharing agreement, it now broadcasts from WVPT's transmitter as a satellite of Richmond's WCVW, using virtual channel 51.2.

WCVE-TV
WCVE-TV (channel 23) is a PBS member television station in Richmond, Virginia, United States. Owned by the VPM Media Corporation (formerly known as the Commonwealth Public Broadcasting Corporation), the station maintains studios and a transmitter at 23 Sesame Street in Bon Air, a suburb of Richmond.

WHTJ (channel 41) in Charlottesville operates as a full-time satellite of WCVE-TV; this station's transmitter is located atop Carters Mountain. WCVE-TV also operates a sister station in Richmond, WCVW (channel 57), whose transmitter is co-located with WCVE-TV.

The three stations were collectively branded as the Community Idea Stations from 2001 until 2019, when Commonwealth Public Broadcasting rebranded its stations as VPM (short for Virginia Public Media), with WCVE-TV and WHTJ becoming VPM PBS and WCVW becoming VPM Plus.
Carbon tetrachloride
Carbon tetrachloride, also known by many other names (such as carbon tet for short and tetrachloromethane, also recognised by the IUPAC), is a chemical compound with the chemical formula CCl4. It is a volatile, non-flammable, dense, colourless liquid with a chloroform-like sweet odour that can be detected at low levels. It was formerly widely used in fire extinguishers, as a precursor to refrigerants, an anthelmintic and a cleaning agent, but has since been phased out because of environmental and safety concerns. Exposure to high concentrations of carbon tetrachloride can affect the central nervous system and degenerate the liver and kidneys. Prolonged exposure can be fatal.

Chloroform
Chloroform, or trichloromethane (often abbreviated as TCM), is an organochloride with the formula CHCl3 and a common solvent. It is a volatile, colorless, sweet-smelling, dense liquid produced on a large scale as a precursor to refrigerants and polytetrafluoroethylene (PTFE). Chloroform was once used as an inhalational anesthetic between the 19th century and the first half of the 20th century. It is miscible with many solvents but it is only very slightly soluble in water (only 8 g/L at 20°C).
Jhoot
Jhoot (Urdu: جھوٹ; Lie) is a Pakistani television drama series that was aired on 13 May 2016 on Hum TV. It stars Bushra Ansari, Imran Ashraf, Kamran Jeelani, and Mansha Pasha. It aired every Friday at 8:00 pm, replacing Maan. It ended on 7 October 2016, preceded by Gypsy which was renamed as Dil Banjaara.

Dil Banjaara
Dil Banjaara (Urdu: دل بنجارا lit: The Wanderer Heart), previously entitled Gypsy is a Pakistani drama serial that aired on Hum TV on 14 October 2016, preceded by Jhoot for the 2016 television season. It is directed by Siraj-ul-Haque, written by Faiza Iftikhar and produced by Momina Duraid as a night programming all under her production company MD Productions. It stars Adnan Malik as Sikandar an aspiring photographer along with Sanam Saeed as female lead and Mira Sethi as supporting character.

Indian publications like Pinkvilla and Bollywood Life reported that the plot of the series is inspired by the Hindi film Dilwale Dulhania Le Jayenge (1995).
Roger Palmer, 1st Earl of Castlemaine
Roger Palmer, 1st Earl of Castlemaine, PC (3 September 1634 – 21 July 1705) was an English courtier, diplomat and politician who sat in the House of Commons of England for part of 1660. He was also a noted Roman Catholic writer. His wife, Barbara Villiers, was one of Charles II's mistresses.

Barbara Palmer, 1st Duchess of Cleveland
Barbara Palmer, 1st Duchess of Cleveland, Countess of Castlemaine (née Barbara Villiers /ˈvɪlərz/ VIL-ərz; 27 November [O.S. 17 November] 1640 – 9 October 1709), was an English royal mistress of the Villiers family and perhaps the most notorious of the many mistresses of King Charles II of England, by whom she had five children, all of them acknowledged and subsequently ennobled. Barbara was the subject of many portraits, in particular by court painter Sir Peter Lely.

Barbara's first cousin, Elizabeth Villiers (later 1st Countess of Orkney 1657–1733), was the presumed mistress of King William III. King William was the King of England, Scotland, and Ireland from 1689 to 1702.
Soyuz TMA-16
The Soyuz TMA-16 (Russian: Союз TMA-16) was a crewed flight to and from the International Space Station (ISS). It transported two members of the Expedition 21 crew and a Canadian entrepreneur from the Baikonur Cosmodrome in Kazakhstan to the ISS. TMA-16 was the 103rd flight of a Soyuz spacecraft, the first flight launching in 1967. The launch of Soyuz TMA-16 marked the first time since 1969 that three Soyuz craft were in orbit simultaneously.

Guy Laliberté, founder and CEO of Cirque du Soleil, was a Space tourist aboard TMA-16 during its flight to the ISS, paying approximately US$35 million for his seat through the American firm Space Adventures. He returned on board the Soyuz TMA-14 spacecraft left as an emergency vehicle during that previous flight. The Soyuz TMA-16 flight spacecraft flew back to Earth with only two crew members.

Soyuz TMA-14
The Soyuz TMA-14 (Russian: Союз ТМА-14, Union TMA-14) was a Soyuz flight to the International Space Station, which launched on 26 March 2009. It transported two members of the Expedition 19 crew as well as spaceflight participant Charles Simonyi on his second self-funded flight to the space station. TMA-14 was the 101st crewed flight of a Soyuz spacecraft, including launch failures; however, it was the 100th to launch and land crewed, as Soyuz 34 was launched uncrewed to replace Soyuz 32, which landed empty.
Yeh Dil Aap Ka Huwa
Yeh Dil Aap ka Huwa (Urdu: یہ دِل آپ کا ہوا, lit. 'This heart is yours') is a 2002 Lollywood Urdu film starring Sana, Moammar Rana and Saleem Sheikh among others. It was directed by Jawed Sheikh. The film's soundtrack is composed by Amjad Bobby.

The film won 8 Nigar Awards in 2002.

Jawed Sheikh
Jawed Sheikh (also spelled Javaid and Javed; born 8 October 1954) is a Pakistani actor, film director and producer who works in Lollywood and Bollywood. He is best known for working in the Hindi films Om Shanti Om, My Name Is Anthony Gonsalves, Money Hai Toh Honey Hai, Namastey London, etc.
Ichneutica infensa
Ichneutica infensa is a moth of the family Noctuidae. This species is endemic to New Zealand. It is found throughout the North and South Islands but appears to be rarely seen or collected in the north and west parts of the North Island. As at 2019 the northern limit to the range of this species is Titirangi. I. infensa inhabits tussock grasslands and native forest. Larvae are nocturnal and its host plants are in the genus Carex including Carex solandri. Larvae have also been raised on Bromus catharticus. Adults of this species are on the wing from late October to February. Adults are narrow winged with patterns on the forewings that are relatively distinctive. However this species can possibly be confused with I. inscripta.

Ichneutica inscripta
Ichneutica inscripta is a moth of the family Noctuidae. This species is endemic to New Zealand. This species is found from south Auckland to Taranaki in the North Island. It prefers to inhabit dense native forest with high rainfall at higher altitudes. The life history of this species is unconfirmed as are the host species of its larvae but is likely to be similar to its close relative I. infensa. This species is very similar in appearance to its close relative I. infensa but has more strongly patterned forewings. The adults of this species are on the wing from late October to January.
Rocca di Papa
Rocca di Papa (Roman Castles Romanesco: 'A Rocca) is a small town and comune (municipality) in the Metropolitan City of Rome, Lazio, Italy. It is one of the Castelli Romani about 25 kilometres (16 mi) southeast of Rome on the Alban Hills. It is close to the other communes of Velletri, Rocca Priora, Monte Compatri, Grottaferrata, Albano and Marino. It is the center of the Regional Park known as the "Parco Regionale dei Castelli Romani".

Roman Castles
The Roman Castles (Italian: Castelli Romani) are a group of comuni in the Metropolitan City of Rome. They are located a short distance south-east of the city of Rome, at the feet of the Alban Hills, in the territory corresponding to the Old Latium.
Kanchan Kanya Express
The 13149 / 13150 Kanchan Kanya Express is an Express train belonging to the Eastern Railways. It runs between Sealdah, in the city of Kolkata, and Alipurduar Junction via Barddhaman, Rampurhat, Malda Town, Siliguri and New Mal Jn.

New Mal Junction railway station
New Mal Junction also known as New Malbazar Junction (station code NMZ)  is the major railway station among two railway stations which serve the Municipality of Malbazar, the other being Malbazar Railway Station (code MLBZ). This station is commonly known as Mal, It lies in Jalpaiguri district of West Bengal. New Mal Junction lies on two railway line New Jalpaiguri–Alipurduar–Samuktala Road line and is the originating point of New Mal–Changrabandha–New Cooch Behar line. New Mal is the headquarter station of Sub-Divisional Railway officer designated as Assistant Divisional Engineer.
Lester Abrams
Lester Abrams (born 1945) is a singer, songwriter, musician and producer who has played with such artists as B.B. King, Stevie Wonder, Peabo Bryson, Quincy Jones, Manfred Mann, Brian Auger, The Average White Band, The Doobie Brothers, Rufus and many others. Two of his co-compositions appeared on the Grammy Award–winning Doobie Brothers’ album Minute by Minute. He has also composed songs for film and television; two of his works can be heard in the Oliver Stone–produced movie South Central.

Lester Abrams was also a member of and/or associated with several other bands and people, including Leslie Smith, Arno Lucas, Rick Chudacoff, The Les Smith Soul Band, L.A. Carnival, Crackin' and more recently, Connie Price and the Keystones.

Connie Price and the Keystones
Connie Price and the Keystones is a project helmed by guitarist/multi-instrumentalist Dan Ubick from Los Angeles, California, combining influences of funk, hip-hop, psych and soul. Besides Ubick, it had a revolving membership while they performed as a backing band to Big Daddy Kane from 2008 to 2012. As a studio artist, Connie Price and the Keystones have released original recordings on three albums, two EPs and a number of singles.
Berlin/Brandenburg Metropolitan Region
The Berlin/Brandenburg metropolitan region (German: Metropolregion Berlin-Brandenburg) or capital region (German: Hauptstadtregion Berlin-Brandenburg) is one of eleven metropolitan regions of Germany, consisting of the entire territories of the state of Berlin and the surrounding state of Brandenburg. The region covers an area of 30,545 square kilometres (11,793 mi2) with a total population of about 6.2 million.

The metropolitan region should be distinguished from Berlin's immediate agglomeration, dubbed Berliner Umland (English: Berlin's surrounding countryside or Berlin's countryside) which comprises the city and the nearby Brandenburg municipalities. Berliner Umland is significantly smaller and much more densely populated than the metropolitan region, accounting for the vast majority of the region's population over a fraction of its total land area.

Metropolitan regions in Germany
There are eleven metropolitan regions in Germany consisting of the country's most densely populated cities and their catchment areas. They represent Germany's political, commercial and cultural centres. The eleven metropolitan regions in Germany were organised into political units for planning purposes.

Based on a narrower definition of metropolises commonly used to determine the metropolitan status of a given city, only four cities in Germany surpass the threshold of at least one million inhabitants within their administrative borders: Berlin, Hamburg, Munich, and Cologne.

For urban centres outside metropolitan areas that are a similar focal point for their region, but on a smaller scale, the concept of the Regiopolis and the related concepts of regiopolitan area or regio were introduced by urban and regional planning professors in 2006.