hotchpotch/wikipedia-multilingual-ir-related-lead-pairs huggingface dataset:
RhoGEF domain
RhoGEF domain describes two distinct structural domains with  guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family. Rho small GTPases are inactive when bound to GDP but active when bound to GTP; RhoGEF domains in proteins are able to promote GDP release and GTP binding to activate specific Rho family members, including RhoA, Rac1 and Cdc42.

The largest class of RhoGEFs is composed of proteins containing the "Dbl-homology" (DH) domain, which almost always is found together with a pleckstrin-homology (PH) domain to form a combined DH/PH domain structure.

A distinct class of RhoGEFs is those proteins containing the DOCK/CZH/DHR-2 domain. This structure has no sequence similarity with DBL-homology domains.

MCF2
Proto-oncogene DBL is a protein that in humans is encoded by the MCF2 gene.

The commonly used name DBL is derived from “diffuse B-cell lymphoma”, the cancer type where this gene was first identified as an oncogene, while the name MCF2 name derives from “MCF.2 cell line-derived transforming sequence”.

DBL is the founding member of a large family of guanine nucleotide exchange factors that share a common DBL-homology (DH) domain), so DBL is also named as a member of this RhoGEF family as ARHGEF21. DH domains function to activate small GTPases of the Rho family by facilitating release of GDP from an inactive Rho GTPase and binding of GTP to activate it. In particular, DBL activates the Rho family member Cdc42.

Gene recombinations that result in the loss of N-terminal regions produce MCF2 variants with oncogenic activity.[supplied by OMIM]
Pema Khandu
Pema Khandu (born 21 August 1979) is an Indian politician who is serving 9th and current Chief Minister of Arunachal Pradesh since 2016 and also serving as leader of the house in legislative assembly. He is the son of former Chief Minister Dorjee Khandu. Since assuming the office of the Chief Minister in July 2016, he and his government have twice changed their party affiliation; in September 2016 from the Indian National Congress to the People's Party of Arunachal, and then in December 2016 to the Bharatiya Janata Party. Previously he had served as Minister of Tourism, Urban Development and Water Resources in Nabam Tuki's government.

Chief Minister of Arunachal Pradesh
The chief minister of Arunachal Pradesh is chief executive of the Indian state of Arunachal Pradesh. As per the Constitution of India, the governor of Arunachal Pradesh is the state's de jure head, but de facto executive authority rests with the chief minister. Following elections to the Arunachal Pradesh Legislative Assembly, the governor usually invites the party (or coalition) with a majority of seats to form the government. The governor appoints the chief minister, whose council of ministers are collectively responsible to the assembly. Given that he has the confidence of the assembly, the chief minister's term is for five years and is subject to no term limits. Pema Khandu of the Bharatiya Janata Party is the current incumbent. Chief Minister also serves as Leader of the House in the Legislative Assembly.
Galerie Chalette
Galerie Chalette was a private contemporary art gallery in Manhattan, New York, USA. It was founded by the married art dealers and collectors Madeleine Chalette Lejwa (1915–1996) and Arthur Lejwa (1895–1972) in February 1954. The Lejwas were refugees from the Nazi invasions of Poland and France. Initially, their gallery specialized in contemporary French and Polish prints and painting. Later they changed its focus to contemporary 20th century American and European Sculpture, and especially the work of Jean Arp.

"La Chalette" was best known for organizing important group exhibitions which were then offered to various museums around the United States, including Construction and Geometry in Painting (1960),  and Structured Sculpture (1960, 1968), as well as their major Arp exhibition, Jean Arp : from the collections of Mme. Marguerite Arp and Arthur and Madeleine Lejwa, at the Metropolitan Museum of Art, in 1972.

The gallery closed in 1978.

Jean Arp
Hans Peter Wilhelm Arp (/ɑːrp/; German: [aʁp]; 16 September 1886 – 7 June 1966), better known as Jean Arp in English, was a German-French sculptor, painter and poet. He was known as a Dadaist and an abstract artist.
Hellifield railway station
Hellifield is a junction railway station on the Bentham Line, which runs between Leeds and Morecambe via Skipton, as well as being the northern terminus of the Ribble Valley line. The station, situated 36 miles 17 chains (58.3 km) north-west of Leeds, serves the village of Hellifield, in North Yorkshire, England. It is owned by Network Rail and managed by Northern Trains.

Ribble Valley line
The Ribble Valley line is a railway line that runs from Manchester Victoria through Blackburn, in Lancashire, to Hellifield in North Yorkshire. Regular passenger services normally run as far as Clitheroe, but occasional passenger services run the whole line through north Lancashire to Hellifield, where there are connections to the Settle–Carlisle and Bentham lines. The line passes over the distinctive 48-span Whalley Viaduct.

The line north of Blackburn was closed to a regular passenger service from September 1962, but remained open for freight, passenger diversions and the occasional DalesRail service. However, in 1994, services between Blackburn and Clitheroe were reinstated after a public campaign. Reopening the line for passengers between Clitheroe and Hellifield has been mentioned in some reports and newspapers to provide connections on the Settle Carlisle line, with the most recent being a business case for the proposal being granted government funds in 2020.
Davy Crockett National Forest
Davy Crockett National Forest is in southeast Texas between the towns of Lufkin and Crockett, Texas. It is administered by the United States Department of Agriculture Forest Service local headquarters in Lufkin. There are local ranger district offices located in Ratcliff.

The forest, part of the Piney Woods ecoregion, covers a total of 160,647 acres (251.0 sq mi; 650.1 km2) in two counties - Houston 94,481 acres (147.6 sq mi; 382.4 km2) and Trinity 67,361 acres (105.3 sq mi; 272.6 km2).

Davy Crockett National Forest, which is bordered on the northeast by the Neches River and is located around Kennard, Texas, includes the 45-acre (180,000 m2) Ratcliff Lake. The area is pine-hardwood woodlands with flat to gently rolling terrain.

Houston County, Texas
Houston County is a county located in the U.S. state of Texas. As of the 2020 census, its population was 22,066. Its county seat is Crockett. Houston County was one of 46 entirely dry counties in the state of Texas, until voters in a November 2007 special election legalized the sale of alcohol in the county.

Houston County was the first new county created under the nine-year Republic of Texas on June 12, 1837. The original boundaries of Houston County also included all of present-day Anderson and Trinity Counties, and portions of present-day Henderson and Polk Counties.

The county is named for Sam Houston, President of the Republic of Texas and Governor of Texas. Other than being named for the same person, Houston County is not related to the City of Houston, which is located about 100 mi (160 km) to the south, in Harris County.
Ian Anderson
Ian Scott Anderson MBE (born 10 August 1947) is a British musician best known for being the chief vocalist, flautist, and acoustic guitarist of the British rock band Jethro Tull. He is a multi-instrumentalist who also plays harmonica, keyboard, bass guitar, bouzouki, balalaika, saxophone, and a variety of whistles. His solo work began with Walk into Light in 1983; since then he has released another five albums, including the sequel to the 1972 Jethro Tull album Thick as a Brick, titled TaaB 2: Whatever Happened to Gerald Bostock? (2012).

Thick as a Brick 2
Thick as a Brick 2, abbreviated TAAB 2 and subtitled Whatever Happened to Gerald Bostock?, is the fifth studio album by Jethro Tull frontman Ian Anderson, released in 2012 as a sequel album to Thick as a Brick, Jethro Tull's 1972 parody concept album. It entered the Billboard chart at No. 55.
Wilfrid Laurier University
Wilfrid Laurier University (WLU or simply Laurier) is a public university in Ontario, Canada, with campuses in Waterloo, Brantford and Milton. It is named in honour of Sir Wilfrid Laurier, the seventh Prime Minister of Canada. A "multi-campus multi-community university", Laurier offers undergraduate and graduate programs in a variety of fields with over 17,000 full-time undergraduate students, over 1000 full-time graduate students, and nearly 4,000 part-time students as of late 2019. Laurier's varsity teams, known as the Wilfrid Laurier Golden Hawks, compete in the West Conference of the Ontario University Athletics, affiliated with U Sports.

Milton, Ontario
Milton (2021 census population 132,979) is a town in Southern Ontario, Canada, and part of the Halton Region in the Greater Toronto Area. Between 2001 and 2011, Milton was the fastest growing municipality in Canada, with a 71.4% increase in population from 2001 to 2006 and another 56.5% increase from 2006 to 2011. In 2016, Milton's census population was 110,128 with an estimated growth to 228,000 by 2031. It remained the fastest growing community in Ontario but was deemed to be the sixth fastest growing in Canada at that time.

Milton is located 54 km (34 mi) west of Downtown Toronto on Highway 401, and is the western terminus for the Milton line commuter train and bus corridor operated by GO Transit. Milton is situated on the Niagara Escarpment, a UNESCO world biosphere reserve and the Bruce Trail.
Drangarnir
Drangarnir (lit. 'the sea stacks' in Faroese) is a pair of sea stacks in the North Atlantic Ocean, situated between Tindhólmur and Vágar of the Faroe Islands, a Danish archipelago. The larger sea stack is named Stóri Drangur (lit. 'large sea stack') and the smaller Lítli Drangur (lit. 'small sea stack'). Drangarnir is located near the Faroe Islands' only airport and is a popular attraction among tourists to the archipelago, particularly due to Stóri Drangur's sea arch.

Vágar
Vágar (Faroese pronunciation: [vɔːaɹ]; Danish: Vågø) is one of the 18 islands in the archipelago of the Faroe Islands and the most westerly of the large islands. With a size of 178 square kilometres (69 square miles), it ranks third in size, behind Streymoy and Eysturoy. Vágar region also comprises the island of Mykines.

The Vágar island shape is very distinctive, since on maps it resembles a dog's head. The fjord Sørvágsfjørður is the mouth and the lake Fjallavatn is the eye.
Sydney Mint
The Sydney Mint in Sydney, New South Wales, Australia, is the oldest surviving public building in the Sydney central business district. Built between 1811 and 1816 as the southern wing of the Sydney Hospital, it was then known as the Rum Hospital. In 1854 a mint was established on the site with the hospital building used to house mint staff as well as providing a residence for the Deputy Mint Master. A coining factory was built at the rear. Both of these structures have exceptional heritage significance and have been associated with major events in the colonial history of New South Wales.

Located in Sydney's central business district at 10 Macquarie Street, it is near many other famous Australian historical buildings including Hyde Park Barracks, St James' Church and Parliament House. The building is now the head office of Museums of History NSW and is listed on the New South Wales State Heritage Register. Sections of the building are open to the public.

Museums of History NSW
Museums of History NSW (MHNSW) is a statutory body of the Government of New South Wales that is responsible for historic sites, state collections, and archives in the state of New South Wales, Australia. In 2023, the former State Archives and Records Authority was merged with Sydney Living Museums (formerly known as Historic Houses Trust of New South Wales) to form MHNSW.  MHNSW headquarters are in the The Mint, and sites run by the organisation include various houses, gardens, parklands, and urban spaces across New South Wales.
The Wackness
The Wackness is a 2008 American coming-of-age comedy-drama film written and directed by Jonathan Levine. The film is a semi-autobiographical account of Levine's life growing up in New York City in the 1990s. It stars Ben Kingsley, Josh Peck, Famke Janssen, Olivia Thirlby, Mary-Kate Olsen, and Method Man. It revolves around a troubled teenage drug dealer who trades pot for therapy sessions with a drug-addled psychiatrist.

The film had its world premiere at the Sundance Film Festival on January 18, 2008, where it won the Audience Award: Dramatic. It was theatrically released in the United States on August 1, 2008, by Sony Pictures Classics. It received positive reviews from critics, but was a box-office bomb, grossing $3.3 million worldwide against a $6 million budget. Levine was nominated for Best First Screenplay at the 24th Independent Spirit Awards.

2008 Sundance Film Festival
The 2008 Sundance Film Festival ran from January 17, 2008 to January 27 in Park City, Utah. It was the 24th iteration of the Sundance Film Festival. The opening night film was In Bruges and the closing night film was CSNY/Déjà Vu.
United States Men's Curling Championship
The United States Men's Curling Championship is the annual men's national curling championship for the United States. It is run by the United States Curling Association (USCA) and typically held in conjunction with the Women's Championship. The champion is eligible to represent the United States at the World Men's Curling Championships if they also rank in the top 75 teams over the last two seasons in the World Curling Tour Order of Merit or have earned 40 points in the Order of Merit year-to-date rankings.

World Curling Championships
The World Curling Championships are the annual world championships for curling, organized by the World Curling Federation and contested by national championship teams. There are men's, women's and mixed doubles championships, as well as men's and women's versions of junior and senior championships. There is also a world championship for wheelchair curling. The men's championship started in 1959, while the women's started in 1979. The mixed doubles championship was started in 2008. Since 2005, the men's and women's championships have been held in different venues, with Canada hosting one of the two championships every year: the men's championship in odd years, and the women's championship in even years. Canada has dominated both the men's and women's championships since their inception, although Switzerland, Sweden, Denmark, Germany (West Germany), Scotland, the United States, Norway and China have all won at least one championship.
Transcription factor II D
Transcription factor II D (TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. It consists of RNA polymerase II, a subset of general transcription factors, and regulatory proteins known as SRB proteins.  Before the start of transcription, the transcription Factor II D (TFIID) complex binds to the core promoter DNA of the gene through specific recognition of promoter sequence motifs, including the TATA box, Initiator, Downstream Promoter, Motif Ten, or Downstream Regulatory elements.

RNA polymerase II
RNA polymerase II (RNAP II and Pol II) is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNAP enzymes found in the nucleus of eukaryotic cells. A 550 kDa complex of 12 subunits, RNAP II is the most studied type of RNA polymerase. A wide range of transcription factors are required for it to bind to upstream gene promoters and begin transcription.
Bendigo railway station
Bendigo railway station is a regional railway station on the Deniliquin and Piangil lines, part of the Victorian railway network. It serves the city of Bendigo, Victoria, Australia. Bendigo is a ground level premium station, featuring two side platforms. It opened on 21 October 1862, with the current station provided in 1965. Initially opened as Sandhurst, the station was given its current name of Bendigo on 1 September 1891.

The disused station at Golden Square is located between Bendigo and Kangaroo Flat.

Piangil railway line
The Piangil railway line is a 5 ft 3 in (1,600 mm) gauge railway line in north-western Victoria, Australia. It branches off the Deniliquin line just north of Bendigo, and runs in a north-westerly direction through Pyramid Hill and Kerang to the border town of Swan Hill, then roughly parallels the New South Wales border to Piangil and Yungera. The line is now open only as far as Piangil, and passenger services only operate to Swan Hill.
Madeleine McGraw
Madeleine McGraw (born December 22, 2008) is an American actress. She gained recognition for her roles in various horror-themed projects including the television show Outcast (2016–2018), and the films The Mandela Effect (2019), and The Black Phone (2021) and its 2025 sequel. She has been referred to as a scream queen and earned two Saturn Award nominations for Best Performance by a Younger Actor.

She also starred as Zoey Campbell in the Disney Channel series Secrets of Sulphur Springs (2021–2023) and has portrayed a younger version of Hope van Dyne in the Marvel Cinematic Universe (MCU) film Ant-Man and the Wasp (2018) and the Disney+ series What If...? (2023).

Violet McGraw
Violet Elizabeth McGraw (born April 22, 2011) is an American actress. Her acting debut was a recurring role in the 2016 television series Love as Nina, and her first feature film was 2018's Ready Player One. In 2019 she was nominated for an OFTA Television Award for Best Ensemble in a Motion Picture or Limited Series for The Haunting of Hill House. She is also known for her roles as a young Yelena Belova in the Marvel Studios superhero films Black Widow (2021) and Thunderbolts* (2025), and as Cady in the horror films M3GAN (2022) and M3GAN 2.0 (2025).
Sohmor
Sohmor   (Arabic: سحمر)   is a small town in the Beka'a Valley of Lebanon, situated in the Western Beqaa District and south of the Beqaa Governorate. It lies south of Lake Qaraoun on the Litani River. It lies southwest of Machgara, northeast of Ain Et Tine, north of Yohmor, west of Mazret Al Chmis and northwest of Libbaya.

Yohmor, Beqaa
Yohmor or Yohmor al Beqaa (Arabic: يحمر (البقاع الغربي))  is a large village in the Beka'a Valley of Lebanon, situated in the Western Beqaa District in the south of the Beqaa Governorate. It lies south of Sohmor.
The main source of income comes from olive cultivation.
Perodua Alza (first generation)
The M500 series Perodua Alza is the first generation of Alza B-segment multi-purpose vehicle (MPV) produced by Malaysian car manufacturer Perodua. Based on the Daihatsu Boon Luminas, it was launched in November 2009 as the company's first purpose-built MPV.

The production of M500 series Alza ended in 2022 before being replaced by the W100 series Daihatsu Xenia-based model.

Perodua Myvi
The Perodua Myvi is a subcompact car/supermini (B-segment) produced by the Malaysian manufacturer Perodua since 2005. Based on the Daihatsu Boon (also branded as Daihatsu Sirion, Toyota Passo and Subaru Justy), the Myvi is the result of Perodua's collaboration with both Toyota and Daihatsu. However, the third generation Myvi was entirely designed and made in Malaysia, thus not being based on the third generation Boon. The Myvi was the best-selling car in Malaysia for nine consecutive years, between 2006 and 2014, and again between the years 2018 and 2022. The Myvi has been Malaysia's best-selling car for 14 years since its first full year of sales in 2006. By the end of 2024, the Myvi reached 1.487 million units sold since the launch of its first generation in 2005 as Perodua's best-selling nameplate.

The name "Myvi" is derived from "My Vehicle," "My Vision" and "Malaysian Vision."
John Stephenson (physician)
John Stephenson (December 12, 1796 – February 2, 1842) was a Canadian physician and educator, and one of the founders of the Montreal Medical Institution, the first medical school in Canada. He is regarded as one of the founders of McGill University Faculty of Medicine.

McGill Faculty of Medicine and Health Sciences
The McGill Faculty of Medicine and Health Sciences is one of the constituent faculties of McGill University. It was established in 1829 after the Montreal Medical Institution was incorporated into McGill College as the college's first faculty; it was the first medical faculty to be established in Canada. The Faculty awarded McGill’s first degree, and Canada’s first medical degree, to William Leslie Logie in 1833.”

There have been at least two Nobel Prize laureates who have completed their entire education at McGill University including MD at the Faculty of Medicine and Health Sciences including Andrew Schally (Nobel Prize in Physiology or Medicine 1977) and David H. Hubel (Nobel Prize in Physiology or Medicine 1981).
Prince Henry of Battenberg
Prince Henry of Battenberg (Henry Maurice; 5 October 1858 – 20 January 1896), formerly Count Henry of Battenberg, was a German prince who became a member of the British royal family by marriage to Princess Beatrice, the youngest child of Queen Victoria. He was the son of Prince Alexander of Hesse and by Rhine, but did not belong to the House of Hesse because his mother, Countess Julia von Hauke, was of a lower rank. He moved to the United Kingdom when he married Beatrice in 1885 and became governor of the Isle of Wight in 1894. He died of malaria on his way to fight in the Ashanti War.

Prince Alexander of Hesse and by Rhine
Prince Alexander of Hesse and by Rhine GCB (Alexander Ludwig Georg Friedrich Emil; 15 July 1823 – 15 December 1888), was the third son and fourth child of Louis II, Grand Duke of Hesse, and Wilhelmine of Baden. He was a brother of Tsarina Maria Alexandrovna, wife of Tsar Alexander II of Russia. The Battenberg-Mountbatten family descends from Alexander and his wife Countess Julia von Hauke, a former lady-in-waiting to his sister.
Talke
Talke is a village in the civil parish of Kidsgrove, in the Newcastle-under-Lyme district, in Staffordshire, England. It is 4 miles (6.4 km) northwest of Newcastle-under-Lyme and 1.5 miles (2.4 km) southwest of Kidsgrove.

Kidsgrove
Kidsgrove is a town in the borough of Newcastle-under-Lyme, Staffordshire, England, on the border with Cheshire. It is part of the Potteries Urban Area, along with Stoke-on-Trent and Newcastle-under-Lyme. It has a population of 26,276 (2019 census). Most of the town is in the Kidsgrove ward, whilst the western part is in Ravenscliffe.