NOECs와 LOECs는 가설검증(Dunnett's Test, Bonferroni adjustment, Steel's My-One Rank Test, Wilcoxon Rank Sum Test with Bonferroni adjustment), LCs, ICs, ECs는 점추정기법(Probit Analysis, Spearman-Karber Method, Trimmed Spearman-Karber Method, Graphical Method 또는 Linear Interpolation Method)에 의해 결정된다.