Pharmaceutical_industry

qas: question: Who identified the active substance?
answers: text: John Abel

question: Who marketed epinephrine?
answers: text: Parke Davis

question: As an inhaler, what was epinephrine used to treat?
answers: text: nasal congestion

question: Who developed the method to obtain epinephrine in a pure state?
answers: text: Jokichi Takamine

question: What could epinephrine treat?
answers: text: nasal congestion

question: When did epinephrine stop being available in the United States?
answers: text: 2011

question: What trade name was epinephrine marketed under?
answers: text: Adrenalin

question: Who developed the method to get epinephrine in it's pure form?
answers: text: Jokichi Takamine

question: In what year was epinephrine discovered?
answers: text: 1897

question: What was the trade name of epinephrine?
answers: text: Adrenalin

question: Who first discovered epinephrine?
answers: text: John Abel

question: What is epinephrine used to treat?
answers: text: asthma attacks

question: In what year was Primatene Mist no longer sold in the United States?
answers: text: 2011

question: Who identified the inactive substance?

question: Who marketed Primatene?

question: What trade name was Primatene marketed under?

question: As an inhaler, what was Primatene used to treat?

question: Who developed the method to obtain Primatene in a pure state?
context: By the 1890s the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897 John Abel of Johns Hopkins University identified the active principle as epinephrine, which he isolated in an impure state as the sulfate salt. Industrial chemist Jokichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke Davis. Parke Davis marketed epinephrine under the trade name Adrenalin. Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 (Primatene Mist). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion.

qas: question: Who developed Amphetamine?
answers: text: Smith, Kline and French

question: What are common side effects of Amphetamine?
answers: text: sensations of exhilaration and palpitations

question: When were tricyclic antidepressants developed?
answers: text: 1960s

question: What were some uses for Amphetamine?
answers: text: narcolepsy, post-encepheletic parkinsonism, and mood elevation in depression and other psychiatric indications

question: Who synthesized Amphetamine for asthma?
answers: text: Gordon Alles

question: Ephedrine was used as an oral medicine for what illness?
answers: text: asthma

question: In what year was amphetamine first tested on asthma patients?
answers: text: 1929

question: What was the trade name of amphetamine as a nasal decongestant?
answers: text: Benzedrine Inhaler

question: In what year did the American Medical Association approve amphetamine for medical use?
answers: text: 1937

question: In what decade were tricyclic antidepressants created?
answers: text: 1960s

question: Who developed tricyclics?

question: What are common side effects of tricyclics?

question: When was the American Medical Association developed?

question: What were some uses for the American Medical Association?

question: Who synthesized the American Medical Association for asthma?
context: While highly effective, the requirement for injection limited the use of norepinephrine[clarification needed] and orally active derivatives were sought. A structurally similar compound, ephedrine, was identified by Japanese chemists in the Ma Huang plant and marketed by Eli Lilly as an oral treatment for asthma. Following the work of Henry Dale and George Barger at Burroughs-Wellcome, academic chemist Gordon Alles synthesized amphetamine and tested it in asthma patients in 1929. The drug proved to have only modest anti-asthma effects, but produced sensations of exhilaration and palpitations. Amphetamine was developed by Smith, Kline and French as a nasal decongestant under the trade name Benzedrine Inhaler. Amphetamine was eventually developed for the treatment of narcolepsy, post-encepheletic parkinsonism, and mood elevation in depression and other psychiatric indications. It received approval as a New and Nonofficial Remedy from the American Medical Association for these uses in 1937 and remained in common use for depression until the development of tricyclic antidepressants in the 1960s.

qas: question: What is diabetes caused from?
answers: text: absence of a substance normally produced by the pancreas

question: Before insulin, what was the life expectancy of diabetics?
answers: text: only a few months

question: How can diabetes be induced in dogs?
answers: text: surgical removal of the pancreas

question: Who discovered that pancreatic extract reversed symptoms of pancreas removal?
answers: text: Frederick Banting and his student Charles Best

question: Why was insulin therapy delayed?
answers: text: difficulties in producing the material in sufficient quantity and with reproducible purity

question: Diabetes is caused by the removal of what organ?
answers: text: pancreas

question: Left untreated, how long were diabetic patients were expected to live?
answers: text: a few months

question: What could be adjusted in a sample of pancreatic extract to produce purer insulin?
answers: text: pH

question: To purify insulin, Banting and Best sought the assistance of what company?
answers: text: Eli Lilly and Co.

question: Minkowski and von Mering did surgical tests on what animal?
answers: text: dogs

question: What is purification caused from?

question: Before insulin, what was the life expectancy of purification?

question: How can purification be induced in dogs?

question: Who discovered that pancreatic extract reversed symptoms of purification removal?

question: Why was purification therapy delayed?
context: A series of experiments performed from the late 1800s to the early 1900s revealed that diabetes is caused by the absence of a substance normally produced by the pancreas. In 1869, Oskar Minkowski and Joseph von Mering found that diabetes could be induced in dogs by surgical removal of the pancreas. In 1921, Canadian professor Frederick Banting and his student Charles Best repeated this study, and found that injections of pancreatic extract reversed the symptoms produced by pancreas removal. Soon, the extract was demonstrated to work in people, but development of insulin therapy as a routine medical procedure was delayed by difficulties in producing the material in sufficient quantity and with reproducible purity. The researchers sought assistance from industrial collaborators at Eli Lilly and Co. based on the company's experience with large scale purification of biological materials. Chemist George Walden of Eli Lilly and Company found that careful adjustment of the pH of the extract allowed a relatively pure grade of insulin to be produced. Under pressure from Toronto University and a potential patent challenge by academic scientists who had independently developed a similar purification method, an agreement was reached for non-exclusive production of insulin by multiple companies. Prior to the discovery and widespread availability of insulin therapy the life expectancy of diabetics was only a few months.

qas: question: What is phenobarbital used for?
answers: text: epilepsy

question: What sleep aid was marketed in 1904?
answers: text: Veronal

question: What is amphetamine used for today?
answers: text: attention deficit disorder

question: Why was barbiturates and amphetamines restricted?
answers: text: addictive properties and abuse potential

question: Who discovered a reaction that induced sleep in dogs?
answers: text: Hermann Emil Fischer and Joseph von Mering

question: What compound was discovered to induce sleep?
answers: text: diethylbarbituric acid

question: What was the first trade name of diethylbarbituric acid?
answers: text: Veronal

question: What is phenobarbital mainly used to treat today?
answers: text: epilepsy

question: In what year was phenobarbital discovered?
answers: text: 1911

question: What was Veronal used for when Bayer put it on the market?
answers: text: sleep aid

question: What is increased awareness used for?

question: What acid was marketed in 1904?

question: What is acid used for today?

question: Why were acids restricted? 

question: Who discovered an acid reaction?
context: In 1903 Hermann Emil Fischer and Joseph von Mering disclosed their discovery that diethylbarbituric acid, formed from the reaction of diethylmalonic acid, phosphorus oxychloride and urea, induces sleep in dogs. The discovery was patented and licensed to Bayer pharmaceuticals, which marketed the compound under the trade name Veronal as a sleep aid beginning in 1904. Systematic investigations of the effect of structural changes on potency and duration of action led to the discovery of phenobarbital at Bayer in 1911 and the discovery of its potent anti-epileptic activity in 1912. Phenobarbital was among the most widely used drugs for the treatment of epilepsy through the 1970s, and as of 2014, remains on the World Health Organizations list of essential medications. The 1950s and 1960s saw increased awareness of the addictive properties and abuse potential of barbiturates and amphetamines and led to increasing restrictions on their use and growing government oversight of prescribers. Today, amphetamine is largely restricted to use in the treatment of attention deficit disorder and phenobarbital in the treatment of epilepsy.

qas: question: Who developed Arsphenamine?
answers: text: Paul Ehrlich and chemist Alfred Bertheim

question: What was the first effective treatment for Syphilis?
answers: text: Arsphenamine

question: What complications are associated with Syphilis?
answers: text: severe skin ulceration, neurological damage, and death

question: What is Amphetamine's market name?
answers: text: Institute of Experimental Therapy

question: Where is the Institute of Experimental Therapy located?
answers: text: Berlin

question: What was the name of the first synthetic bacterial drug?
answers: text: arsphenamine

question: Bacterial infections could be treated with medicines containing what kind of dye?
answers: text: arsenic

question: Arsphenamine became the first treatment for what previously incurable disease?
answers: text: syphilis

question: In what year was arsphenamine discovered?
answers: text: 1911

question: What was the commercial name of arsphenamine?
answers: text: Salvarsan

question: Who developed commercial ulceration?

question: What was the first effective treatment for Bertheim?

question: What complications are associated with Bertheim?

question: What is Bertheim's market name?

question: Where is the Institute of Bertheim located?
context: In 1911 arsphenamine, the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of the Institute of Experimental Therapy in Berlin. The drug was given the commercial name Salvarsan. Ehrlich, noting both the general toxicity of arsenic and the selective absorption of certain dyes by bacteria, hypothesized that an arsenic-containing dye with similar selective absorption properties could be used to treat bacterial infections. Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds, and found to exhibit partially selective toxicity. Arsphenamine proved to be the first effective treatment for syphilis, a disease which prior to that time was incurable and led inexorably to severe skin ulceration, neurological damage, and death.[citation needed]

qas: question: When was Morphine and Quinine first available?
answers: text: mid 1800s

question: Who was the compound named after?
answers: text: Morpheus

question: Where were was Morphine extracted from?
answers: text: opium

question: Who is responsible for purification of compounds found in mineral sources?
answers: text: German dye manufacturers

question: Who came up with the name Morphine?
answers: text: Friedrich Sertürner

question: Morphine was named after what Greek god?
answers: text: Morpheus

question: Burroughs-Wellcome is now part of what medical company?
answers: text: Glaxo Smith Kline

question: Who discovered morphine?
answers: text: Friedrich Sertürner

question: What is the name of the plant that produces morphine?
answers: text: opium

question: When was Glaxo first available?

question: Who was Glaxo named after?

question: Where was Glaxo extracted from?

question: Who is responsible for purification of Glaxo found in mineral sources?

question: Who came up with the name Glaxo?
context: The modern pharmaceutical industry traces its roots to two sources. The first of these were local apothecaries that expanded from their traditional role distributing botanical drugs such as morphine and quinine to wholesale manufacture in the mid 1800s. Rational drug discovery from plants started particularly with the isolation of morphine, analgesic and sleep-inducing agent from opium, by the German apothecary assistant Friedrich Sertürner, who named the compound after the Greek god of dreams, Morpheus. Multinational corporations including Merck, Hoffman-La Roche, Burroughs-Wellcome (now part of Glaxo Smith Kline), Abbott Laboratories, Eli Lilly and Upjohn (now part of Pfizer) began as local apothecary shops in the mid-1800s. By the late 1880s, German dye manufacturers had perfected the purification of individual organic compounds from coal tar and other mineral sources and had also established rudimentary methods in organic chemical synthesis. The development of synthetic chemical methods allowed scientists to systematically vary the structure of chemical substances, and growth in the emerging science of pharmacology expanded their ability to evaluate the biological effects of these structural changes.

qas: question: Who received the Nobel Prize in Medicine in 1939?
answers: text: Gerhard Domagk

question: Who is responsible for creating Prontosil?
answers: text: Josef Klarer, Fritz Mietzsch, and Gerhard Domagk

question: What causes Streptococci?
answers: text: pathogens

question: Many deaths occurred before World War II due to what?
answers: text: infectious diseases

question: Prontosil is in what drug class?
answers: text: antibiotics

question: What was the name of the first sulfonamine antibiotic?
answers: text: Prontosil

question: What award did Domagk receive in 1939?
answers: text: Nobel Prize in Medicine

question: Anti-infective drugs became more prominent after what war?
answers: text: World War II

question: Were sulfonamides more or less toxic than arsphenamine?
answers: text: less

question: Streptococci and other pathogens could be treated by what type of antibiotics?
answers: text: sulfonamides

question: Who received the Nobel Prize in Medicine in 1938?

question: Who is responsible for creating German dye?

question: What causes Gerhard?

question: Many deaths occurred after World War II due to what?

question: Gerhard is in what drug class?
context: Ehrlich’s approach of systematically varying the chemical structure of synthetic compounds and measuring the effects of these changes on biological activity was pursued broadly by industrial scientists, including Bayer scientists Josef Klarer, Fritz Mietzsch, and Gerhard Domagk. This work, also based in the testing of compounds available from the German dye industry, led to the development of Prontosil, the first representative of the sulfonamide class of antibiotics. Compared to arsphenamine, the sulfonamides had a broader spectrum of activity and were far less toxic, rendering them useful for infections caused by pathogens such as streptococci. In 1939, Domagk received the Nobel Prize in Medicine for this discovery. Nonetheless, the dramatic decrease in deaths from infectious diseases that occurred prior to World War II was primarily the result of improved public health measures such as clean water and less crowded housing, and the impact of anti-infective drugs and vaccines was significant mainly after World War II.

qas: question: Who created the first rabies vaccine?
answers: text: Louis Pasteur and Pierre Paul Émile Roux

question: How many cases of Diphtheria were there in 1921?
answers: text: 206,000

question: In 1923, what was discovered to be safer to treat Diphtheria Toxin?
answers: text: formaldehyde

question: Who created a vaccine to treat Japanese Encephalitis?
answers: text: Maurice Hilleman

question: How many deaths occurred due to Diphtheria?
answers: text: 15,520

question: The rabies vaccine was created in what year?
answers: text: 1885

question: In what year was the diphtheria vaccine made?
answers: text: 1914

question: What compound made the diphtheria vaccine safer to use?
answers: text: formaldehyde

question: Who developed the first encephalitis vaccine? 
answers: text: Maurice Hilleman

question: What company did Hilleman later work for?
answers: text: Merck

question: Who created the first encephelitis vaccine?

question: How many cases of encephelitis where there in 1921?

question: In 1923, what was discovered to be safer to treat encephelitis?

question: Who created a vaccine to treat United States Encephalitis?

question: How many deaths occurred due to encephelitis?
context: Early progress toward the development of vaccines occurred throughout this period, primarily in the form of academic and government-funded basic research directed toward the identification of the pathogens responsible for common communicable diseases. In 1885 Louis Pasteur and Pierre Paul Émile Roux created the first rabies vaccine. The first diphtheria vaccines were produced in 1914 from a mixture of diphtheria toxin and antitoxin (produced from the serum of an inoculated animal), but the safety of the inoculation was marginal and it was not widely used. The United States recorded 206,000 cases of diphtheria in 1921 resulting in 15,520 deaths. In 1923 parallel efforts by Gaston Ramon at the Pasteur Institute and Alexander Glenny at the Wellcome Research Laboratories (later part of GlaxoSmithKline) led to the discovery that a safer vaccine could be produced by treating diphtheria toxin with formaldehyde. In 1944, Maurice Hilleman of Squibb Pharmaceuticals developed the first vaccine against Japanese encephelitis. Hilleman would later move to Merck where he would play a key role in the development of vaccines against measles, mumps, chickenpox, rubella, hepatitis A, hepatitis B, and meningitis.

qas: question: What drug killed 100 people in 1937?
answers: text: Elixir Sulfanilamide

question: Who manufactured "Elixir Sulfanilamide"?
answers: text: S.E. Massengill Company

question: What year did Congress pass the Federal Food, Drug, and Cosmetic Act?
answers: text: 1938

question: What is Diethylene Glycol commonly used for now?
answers: text: antifreeze

question: What was one of the things the Federal Food, Drug and Cosmetic Act do?
answers: text: explicitly prohibited false therapeutic claims

question: What drug killed over 100 people in 1937?
answers: text: Elixir Sulfanilamide

question: What company manufactured Elixir Sulfanilamide? 
answers: text: S.E. Massengill Company of Tennessee

question: Diethylene glycol is mainly used today as what liquid?
answers: text: antifreeze

question: What law did Congress pass following the Elixir Sulfanilamide incident?
answers: text: Federal Food, Drug, and Cosmetic Act of 1938

question: The name "elixir" implied a solution in what liquid?
answers: text: ethanol

question: What drug killed 1900 people in 1937?

question: Who manufactured "Cosmetic Elixir"?

question: What year did Elixir pass the Federal Food, Drug, and Cosmetic Act?

question: What is Elixir Glycol commonly used for now?

question: What was one of the things the Federal Food, Drug and Elixir Act did?
context: In 1937 over 100 people died after ingesting "Elixir Sulfanilamide" manufactured by S.E. Massengill Company of Tennessee. The product was formulated in diethylene glycol, a highly toxic solvent that is now widely used as antifreeze. Under the laws extant at that time, prosecution of the manufacturer was possible only under the technicality that the product had been called an "elixir", which literally implied a solution in ethanol. In response to this episode, the U.S. Congress passed the Federal Food, Drug, and Cosmetic Act of 1938, which for the first time required pre-market demonstration of safety before a drug could be sold, and explicitly prohibited false therapeutic claims.

qas: question: When was the first effective treatment for Tuberculosis discovered?
answers: text: 1943

question: What drug effectively treated Tuberculosis?
answers: text: Streptomycin

question: Who was Eli Lilly's work based off of?
answers: text: Giuseppe Brotzu and Edward Abraham

question: Where was Tetracyclines discovered?
answers: text: Lederle Laboratories

question: 50% of tuberculosis-infected people died within 5 years where?
answers: text: cities in developed countries

question: What was the first treatment for tuberculosis?
answers: text: Streptomycin

question: What percentage of patients infected with tuberculosis died within 5 years?
answers: text: 50%

question: In what year was streptomycin discovered?
answers: text: 1943

question: Many more antibiotics were made following the end of what war?
answers: text: World War II

question: What company funded the research that led to the discovery of streptomycin?
answers: text: Merck

question: When was the first effective treatment for Streptomycin discovered?

question: What drug effectively treated drugs?

question: Who was Eli Smith's work based off of?

question: 50% of tuberculosis-infected people died within 3 years where?

question: What was the first treatment of drugs?
context: The aftermath of World War II saw an explosion in the discovery of new classes of antibacterial drugs including the cephalosporins (developed by Eli Lilly based on the seminal work of Giuseppe Brotzu and Edward Abraham), streptomycin (discovered during a Merck-funded research program in Selman Waksman's laboratory), the tetracyclines (discovered at Lederle Laboratories, now a part of Pfizer), erythromycin (discovered at Eli Lilly and Co.) and their extension to an increasingly wide range of bacterial pathogens. Streptomycin, discovered during a Merck-funded research program in Selman Waksman's laboratory at Rutgers in 1943, became the first effective treatment for tuberculosis. At the time of its discovery, sanitoriums for the isolation of tuberculosis-infected people were an ubiquitous feature of cities in developed countries, with 50% dying within 5 years of admission.

qas: question: When was the Polio vaccine created?
answers: text: 1954

question: Who identified the SV40 virus?
answers: text: Maurice Hilleman

question: What was a complication of the SV40 virus?
answers: text: cause tumors

question: Who funded the Polio vaccine?
answers: text: National Foundation for Infantile Paralysis

question: Who announced that SV40 was not associated with cancer?
answers: text: United States Cancer Institute

question: In what year was the polio vaccine created?
answers: text: 1954

question: Who created the polio vaccine?
answers: text: Jonas Salk

question: What virus caused tumors in most mammals?
answers: text: SV40

question: Who identified the SV40 virus?
answers: text: Maurice Hilleman

question: SV40 was present in what vaccine?
answers: text: polio

question: When was the Paralysis vaccine created?

question: Who identified the SV50 virus?

question: What was a complication of the SV50 virus?

question: Who funded the Paralysis vaccine?

question: Who announced that SV50 was not associated with cancer?
context: During the years 1940-1955, the rate of decline in the U.S. death rate accelerated from 2% per year to 8% per year, then returned to the historical rate of 2% per year. The dramatic decline in the immediate post-war years has been attributed to the rapid development of new treatments and vaccines for infectious disease that occurred during these years. Vaccine development continued to accelerate, with the most notable achievement of the period being Jonas Salk's 1954 development of the polio vaccine under the funding of the non-profit National Foundation for Infantile Paralysis. The vaccine process was never patented, but was instead given to pharmaceutical companies to manufacture as a low-cost generic. In 1960 Maurice Hilleman of Merck Sharp & Dohme identified the SV40 virus, which was later shown to cause tumors in many mammalian species. It was later determined that SV40 was present as a contaminant in polio vaccine lots that had been administered to 90% of the children in the United States. The contamination appears to have originated both in the original cell stock and in monkey tissue used for production. In 2004 the United States Cancer Institute announced that it had concluded that SV40 is not associated with cancer in people.

qas: question: How much was the settlement GlaxoSmithKline agree to?
answers: text: $3 billion

question: What was one of the causes of the health-care fraud case?
answers: text: illegal promotion of prescription drugs

question: When did GlaxoSmithKline plead guilty?
answers: text: 2 July 2012

question: What drugs were related to a kickback scheme?
answers: text: Imitrex, Lotronex, Flovent, and Valtrex

question: What drugs were used for off-label uses?
answers: text: Paxil, Wellbutrin, Advair, Lamictal, and Zofran

question: In what year did GlaxoSmithKline pay a $3 billion dollar settlement?
answers: text: 2012

question: How much was the largest healthcare fraud case in the US settled for?
answers: text: $3 billion

question: What company was sued for promoting medicines for unlicensed uses and bribing doctors?
answers: text: GlaxoSmithKline

question: How much was the settlement Wellbutrin agreed to?

question: What was one of the causes of the Wellbutrin case?

question: When did Wellbutrin plead guilty?

question: What drugs were related to Advair's scheme?

question: What drugs were used for label uses?
context: On 2 July 2012, GlaxoSmithKline pleaded guilty to criminal charges and agreed to a $3 billion settlement of the largest health-care fraud case in the U.S. and the largest payment by a drug company. The settlement is related to the company's illegal promotion of prescription drugs, its failure to report safety data, bribing doctors, and promoting medicines for uses for which they were not licensed. The drugs involved were Paxil, Wellbutrin, Advair, Lamictal, and Zofran for off-label, non-covered uses. Those and the drugs Imitrex, Lotronex, Flovent, and Valtrex were involved in the kickback scheme.

qas: question: What is the speculation of the relationship between doctors and the drug industry?
answers: text: become fully transparent.

question: What is the Physician Financial Transparency Report part of?
answers: text: Sunshine Act

question: Where can you obtain information about the Sunshine Act?
answers: text: Centers for Medicare & Medicaid Services website

question: What information is collected by Centers for Medicine & Medicaid Services?
answers: text: financial relationships with physicians and hospitals.

question: When did Centers for Medicine & Medicaid Services have to start collecting information?
answers: text: starting in 2013

question: The Physician Financial Transparency Reports was part of what other act?
answers: text: Sunshine Act

question: In what year were Medicaid and Medicare required to disclose information about their relationships with doctors and hospitals?
answers: text: 2013

question: Where can financial relationships between Medicaid, Medicare and pharmaceutical companies be found?
answers: text: Centers for Medicare & Medicaid Services website

question: What is expected when the relationships are made public?
answers: text: relationship between doctors and Pharmaceutical industry will become fully transparent

question: What is the speculation of the relationship between organizations and the drug industry?

question: What are doctors part of?

question: Where can you obtain information about organizations?

question: What information is collected by doctors?

question: When did doctors have to start collecting information?
context: In the US, starting in 2013, under the Physician Financial Transparency Reports (part of the Sunshine Act), the Centers for Medicare & Medicaid Services has to collect information from applicable manufacturers and group purchasing organizations in order to report information about their financial relationships with physicians and hospitals. Data are made public in the Centers for Medicare & Medicaid Services website. The expectation is that relationship between doctors and Pharmaceutical industry will become fully transparent.

qas: question: What disease had the biggest decline of deaths?
answers: text: tuberculosis

question: What period was the report issued in 1958 cover?
answers: text: 1946-1955

question: Who issued the report in 1958?
answers: text: Federal Trade Commission

question: What were eight diseases examined for?
answers: text: mortality rates

question: What was responsible for the decline in spreading diseases?
answers: text: use of antibiotics, early diagnosis, and other factors

question: How much did the mortality rate of common bacterial infections decline between 1946-1955?
answers: text: 56%

question: How much did the mortality rate of tuberculosis drop between 1946-1955?
answers: text: 75%

question: Who issued a report describing the effects of antibiotic developments?
answers: text: Federal Trade Commission

question: In what year was the FTC's report issued?
answers: text: 1958

question: What disease had the biggest decline of diagnosis?

question: What period did the report issued in 1964 cover? 

question: Who issued the report in 1964?

question: What were nine diseases examined for?

question: What was responsible for the decline in spreading commissions?
context: A Federal Trade Commission report issued in 1958 attempted to quantify the effect of antibiotic development on American public health. The report found that over the period 1946-1955, there was a 42% drop in the incidence of diseases for which antibiotics were effective and only a 20% drop in those for which antibiotics were not effective. The report concluded that "it appears that the use of antibiotics, early diagnosis, and other factors have limited the epidemic spread and thus the number of these diseases which have occurred". The study further examined mortality rates for eight common diseases for which antibiotics offered effective therapy (syphilis, tuberculosis, dysentery, scarlet fever, whooping cough, meningococcal infections, and pneumonia), and found a 56% decline over the same period. Notable among these was a 75% decline in deaths due to tuberculosis.

qas: question: How much did treatment for each patient in Africa cost?
answers: text: 10,000 and 15,000 USD per patient per year

question: Who brought litigation to South Africa?
answers: text: 40 multi-national pharmaceutical companies

question: How many signatures were collected by MSF?
answers: text: 250,000 signatures

question: When was litigation brought to South Africa?
answers: text: March 2001

question: Who backed the South African government which caused the case to be dropped?
answers: text: The Netherlands, Germany, France, and later the US

question: How many companies sued South Africa for its Medicines Act?
answers: text: 40

question: South Africa's Medicines Act allowed for the generic production of what kind of drugs?
answers: text: antiretroviral

question: How much did ARV drugs cost patients yearly?
answers: text: between 10,000 and 15,000 USD

question: How many signatures were collected supporting public health rights?
answers: text: 250,000

question: How much did treatment for each patient in ARV cost?

question: Who brought litigation to the ARV?

question: How many signatures were collected by ARV?

question: When was litigation brought to ARV?

question: Who backed the ARV government which caused the case to be dropped?
context: In March 2001, 40 multi-national pharmaceutical companies brought litigation against South Africa for its Medicines Act, which allowed the generic production of antiretroviral drugs (ARVs) for treating HIV, despite the fact that these drugs were on-patent. HIV was and is an epidemic in South Africa, and ARVs at the time cost between 10,000 and 15,000 USD per patient per year. This was unaffordable for most South African citizens, and so the South African government committed to providing ARVs at prices closer to what people could afford. To do so, they would need to ignore the patents on drugs and produce generics within the country (using a compulsory license), or import them from abroad. After international protest in favour of public health rights (including the collection of 250,000 signatures by MSF), the governments of several developed countries (including The Netherlands, Germany, France, and later the US) backed the South African government, and the case was dropped in April of that year.

qas: question: What Act forbade misbranded drugs?
answers: text: Pure Food and Drugs Act

question: What caused a Tetanus outbreak?
answers: text: contaminated smallpox vaccine and diphtheria antitoxin

question: What act allowed premarket approval for drugs?
answers: text: The Biologics Control Act of 1902

question: When did the Pure Food and Drugs Act get implemented?
answers: text: 1906

question: Who restricted the federal government's enforcement powers?
answers: text: Supreme Court

question: What was the name of the law that required premarket approval for producing drugs?
answers: text: Biologics Control Act of 1902

question: What law banned the interstate distribution of mislabeled food and drugs? 
answers: text: Pure Food and Drugs Act

question: In what year was the Pure Food and Drugs Act passed?
answers: text: 1906

question: What Act forbade misbranded laws?

question: What caused a law outbreak?

question: What act allowed premarket approval for laws?

question: When did the Pure Food And Laws Act get implemented?

question: Who restricted the federal drug powers?
context: Prior to the 20th century drugs were generally produced by small scale manufacturers with little regulatory control over manufacturing or claims of safety and efficacy. To the extent that such laws did exist, enforcement was lax. In the United States, increased regulation of vaccines and other biological drugs was spurred by tetanus outbreaks and deaths caused by the distribution of contaminated smallpox vaccine and diphtheria antitoxin. The Biologics Control Act of 1902 required that federal government grant premarket approval for every biological drug and for the process and facility producing such drugs. This was followed in 1906 by the Pure Food and Drugs Act, which forbade the interstate distribution of adulterated or misbranded foods and drugs. A drug was considered misbranded if it contained alcohol, morphine, opium, cocaine, or any of several other potentially dangerous or addictive drugs, and if its label failed to indicate the quantity or proportion of such drugs. The government's attempts to use the law to prosecute manufacturers for making unsupported claims of efficacy were undercut by a Supreme Court ruling restricting the federal government's enforcement powers to cases of incorrect specification of the drug's ingredients.

qas: question: Who adopted the Doha Declaration?
answers: text: World Trade Organization

question: What did the TRIPS agreement accomplish?
answers: text: countries must allow pharmaceutical products to be patented

question: Why are patents criticized?
answers: text: thought to reduce access to existing medicines

question: What did the Doha Declaration do?
answers: text: indicates that the TRIPS agreement should be read with the goals of public health in mind, and allows some methods for circumventing pharmaceutical monopolies

question: When was the Doha Declaration adopted?
answers: text: 2001

question: What has been accused of reducing access to medicines in developing countries?
answers: text: Patents

question: When did the World Trade Organization adopt the Doha Declaration?
answers: text: 2001

question: The Doha Declaration allows for what ways for monopolies to be bypassed?
answers: text: compulsory licensing or parallel imports

question: Who adopted the TRIPS Declaration?

question: What did the WTO agreement accomplish?

question: Why is the WTO criticized?

question: What did the WTO Declaration do?

question: When was the TRIPS Declaration adopted?
context: Patents have been criticized in the developing world, as they are thought to reduce access to existing medicines. Reconciling patents and universal access to medicine would require an efficient international policy of price discrimination. Moreover, under the TRIPS agreement of the World Trade Organization, countries must allow pharmaceutical products to be patented. In 2001, the WTO adopted the Doha Declaration, which indicates that the TRIPS agreement should be read with the goals of public health in mind, and allows some methods for circumventing pharmaceutical monopolies: via compulsory licensing or parallel imports, even before patent expiration.

qas: question: How much money was recovered through the False Claims?
answers: text: $2.5 billion

question: What are some of the schemes used to defraud the health care system?
answers: text: Good Manufacturing Practice (GMP) Violations, Off Label Marketing, Best Price Fraud, CME Fraud, Medicaid Price Reporting, and Manufactured Compound Drugs.

question: What is pharmaceutical fraud?
answers: text: deceptions which bring financial gain to a pharmaceutical company

question: Who had the biggest fraud case settlement?
answers: text: GlaxoSmithKline

question: What provision rewards "whistle-blowers"?
answers: text: qui tam

question: What kind of fraud financially benefits a drug company?
answers: text: Pharmaceutical fraud

question: Who is affected by pharmaceutical fraud?
answers: text: individuals and public and private insurers

question: How much money lost to pharmaceutical fraud was recovered in 2010?
answers: text: $2.5 billion

question: Which act allows whistleblowers to recover money lost from pharmaceutical fraud?
answers: text: False Claims Act

question: How much money was recovered through CME Fraud?

question: What are some of the schemes used to defraud companies?

question: What is relator fraud?

question: Who had the biggest relator case settlement?
context: Pharmaceutical fraud involves deceptions which bring financial gain to a pharmaceutical company. It affects individuals and public and private insurers. There are several different schemes used to defraud the health care system which are particular to the pharmaceutical industry. These include: Good Manufacturing Practice (GMP) Violations, Off Label Marketing, Best Price Fraud, CME Fraud, Medicaid Price Reporting, and Manufactured Compound Drugs. Of this amount $2.5 billion was recovered through False Claims Act cases in FY 2010. Examples of fraud cases include the GlaxoSmithKline $3 billion settlement, Pfizer $2.3 billion settlement and Merck & Co. $650 million settlement. Damages from fraud can be recovered by use of the False Claims Act, most commonly under the qui tam provisions which rewards an individual for being a "whistleblower", or relator (law).

qas: question: What do ACE inhibitors do?
answers: text: reduce the risk of new onset kidney disease [RR 0.71] and death [RR 0.84] in diabetic patients

question: What drugs reduce the risk of death and other events in people with high blood pressure?
answers: text: thiazide antihypertensive drugs

question: Who conducted the review on Thiazide Antihypertensive drugs?
answers: text: Cochrane

question: What were Thiazide Antihypertensive drugs used with?
answers: text: combination therapy

question: In what year did Cochrane release the report?
answers: text: 2009

question: What reduces the risk of new onset kidney diseases and death?
answers: text: ACE inhibitors

question: What type of drugs reduced the risk of strokes and heart disease for people with high blood pressure?
answers: text: thiazide antihypertensive drugs

question: In what year was thiazide antihypertensive drugs shown to help those with heart problems?
answers: text: 2009

question: What do RRE inhibitors do?

question: What drugs reduce the risk of death and other events in people with ACE?

question: Who conducted the review on RRE drugs?

question: What were RRE drugs used with?

question: In what year did ACE release the report?
context: A 2009 Cochrane review concluded that thiazide antihypertensive drugs reduce the risk of death (RR 0.89), stroke (RR 0.63), coronary heart disease (RR 0.84), and cardiovascular events (RR 0.70) in people with high blood pressure. In the ensuring years other classes of antihypertensive drug were developed and found wide acceptance in combination therapy, including loop diuretics (Lasix/furosemide, Hoechst Pharmaceuticals, 1963), beta blockers (ICI Pharmaceuticals, 1964) ACE inhibitors, and angiotensin receptor blockers. ACE inhibitors reduce the risk of new onset kidney disease [RR 0.71] and death [RR 0.84] in diabetic patients, irrespective of whether they have hypertension.

qas: question: Who put out a report in 2012?
answers: text: President's Council of Advisors on Science and Technology

question: What has been argued restricted innovation?
answers: text: excessive regulation

question: What was a recommendations brought about from the report?
answers: text: expanding the FDA's use of accelerated approval processes

question: What is one thing excessive regulations causes?
answers: text: therapeutic innovation

question: What can be used to evaluate new approval processes?
answers: text: pilot projects

question: What is excessive drug regulation said to suppress?
answers: text: therapeutic innovation

question: In what year was a report made to reduce the burdens of drug development?
answers: text: 2012

question: What was argued to be holding back new knowledge for treating diseases?
answers: text: current cost of regulator-required clinical trials

question: Who put out a report in 2011?

question: What has been argued restricted population?

question: What was a recommendation brought about from human disease?

question: What is one thing excessive development causes?

question: What can be used to evaluate new human diseases?
context: Others have argued that excessive regulation suppresses therapeutic innovation, and that the current cost of regulator-required clinical trials prevents the full exploitation of new genetic and biological knowledge for the treatment of human disease. A 2012 report by the President's Council of Advisors on Science and Technology made several key recommendations to reduce regulatory burdens to new drug development, including 1) expanding the FDA's use of accelerated approval processes, 2) creating an expedited approval pathway for drugs intended for use in narrowly defined populations, and 3) undertaking pilot projects designed to evaluate the feasibility of a new, adaptive drug approval process.

qas: question: Who discovered Hydralazine?
answers: text: researchers at Ciba

question: Why were the researchers recognized in 1975?
answers: text: the saving of untold thousands of lives and the alleviation of the suffering of millions of victims of hypertension

question: Who developed Chlorothiazide?
answers: text: Karl H. Beyer, James M. Sprague, John E. Baer, and Frederick C. Novello of Merck and Co

question: What is  Chlorothiazide used to treat?
answers: text: hypertension

question: What was the main shortcoming in the drug Hydralazine?
answers: text: lost its effectiveness over time

question: What was the name of the first oral vasodilator?
answers: text: hydralazine

question: What is the most used antihypertensive drug today?
answers: text: chlorothiazide

question: Beyer, Sprague, Baer, and Novello received what award in 1975?
answers: text: Public Health Lasker Award

question: In what year was hydralazine discovered?
answers: text: 1952

question: Chlorothiazide helped reduce the mortality rate among those with what disease?
answers: text: hypertension

question: Who discovered Lasker?

question: Why were the researchers recognized in 1952?

question: who developed Ciba?

question: What is Ciba used to treat?

question: What was the main shortcoming in the drug Ciba?
context: In 1952 researchers at Ciba discovered the first orally available vasodilator, hydralazine. A major shortcoming of hydralazine monotherapy was that it lost its effectiveness over time (tachyphylaxis). In the mid-1950s Karl H. Beyer, James M. Sprague, John E. Baer, and Frederick C. Novello of Merck and Co. discovered and developed chlorothiazide, which remains the most widely used antihypertensive drug today. This development was associated with a substantial decline in the mortality rate among people with hypertension. The inventors were recognized by a Public Health Lasker Award in 1975 for "the saving of untold thousands of lives and the alleviation of the suffering of millions of victims of hypertension".

qas: question: Who led the congressional hearings?
answers: text: Senator Estes Kefauver

question: What act needed provisions?
answers: text: FD&C

question: What were the major issues that needed to be addressed?
answers: text: advertising abuses, questionable efficacy of drugs, and the need for greater regulation of the industry

question: What caused a need for more regulation?
answers: text: a new tragedy emerged

question: When did this push occur?
answers: text: 1959

question: Congressional hearings emerged addressing revisions to what act?
answers: text: FD&C

question: Who led the Congressional hearings in 1959?
answers: text: Senator Estes Kefauver

question: Did the US Congress call for more or less regulation of pharmaceuticals?
answers: text: greater

question: Who led the congressional passages?

question: What congress needed provisions?

question: What were the major issues that needed to be revised?

question: What caused a need for more industry?

question: When did questionable efficacy occur?
context: In the U.S., a push for revisions of the FD&C Act emerged from Congressional hearings led by Senator Estes Kefauver of Tennessee in 1959. The hearings covered a wide range of policy issues, including advertising abuses, questionable efficacy of drugs, and the need for greater regulation of the industry. While momentum for new legislation temporarily flagged under extended debate, a new tragedy emerged that underscored the need for more comprehensive regulation and provided the driving force for the passage of new laws.

qas: question: What did the first measles prevent in it's first 20 years?
answers: text: an estimated 52 million cases of the disease, 17,400 cases of mental retardation, and 5,200 deaths

question: Who originally created the measles vaccine?
answers: text: John Franklin Enders

question: How much did the occurrence of serious diseases shortly after the release of the measles vaccine?
answers: text: >95%

question: When did the Rubella vaccine come out?
answers: text: 1969

question: Who recreated the measles vaccine?
answers: text: Maurice Hilleman

question: In what year was the measles vaccine made?
answers: text: 1962

question: Who helped refine the measles vaccine?
answers: text: Maurice Hilleman

question: In what year was the mumps vaccine made?
answers: text: 1967

question: How much did rubella, measles, and mumps infections drop after vaccination?
answers: text: >95%

question: Measles vaccinations helped prevent how many estimated cases of the illness?
answers: text: 52 million

question: What did the first measles prevent in its first 10 years?

question: Who originally created rubella?

question: How much did the occurrence of serious diseases shortly after the release of rubella?

question: When did measles come out?

question: Who recreated measles?
context: Other notable new vaccines of the period include those for measles (1962, John Franklin Enders of Children's Medical Center Boston, later refined by Maurice Hilleman at Merck), Rubella (1969, Hilleman, Merck) and mumps (1967, Hilleman, Merck) The United States incidences of rubella, congenital rubella syndrome, measles, and mumps all fell by >95% in the immediate aftermath of widespread vaccination. The first 20 years of licensed measles vaccination in the U.S. prevented an estimated 52 million cases of the disease, 17,400 cases of mental retardation, and 5,200 deaths.

qas: question: When did the Kefauver-Harris Amendment become a law?
answers: text: 10 October 1962

question: What did this new law require?
answers: text: all drugs introduced between 1938 and 1962 had to be effective

question: What did the National Academy of Science's study discover?
answers: text: nearly 40 percent of these products were not effective

question: How long after the National Academy of Science's study did a study on over the counter drugs occur?
answers: text: ten years later

question: What brought up enhancement of drug regulations?
answers: text: The thalidomide tragedy

question: When did the Kefauver-Harris Amendment became law?
answers: text: 10 October 1962

question: What federal agency regulated the advertising of prescription drugs?
answers: text: FDA

question: Drugs made between which years had to be tested before going to market?
answers: text: 1938 and 1962

question: What percentage of drugs were shown to be ineffective after an FDA study?
answers: text: 40 percent

question: When did the FDA Amendment become a law?

question: What did this new law prohibit?

question: What did the FDA study discover?

question: How long after the FDA's study did a study on over the counter drugs occur?

question: What brought up enhancement of Congress regulations?
context: The thalidomide tragedy resurrected Kefauver's bill to enhance drug regulation that had stalled in Congress, and the Kefauver-Harris Amendment became law on 10 October 1962. Manufacturers henceforth had to prove to FDA that their drugs were effective as well as safe before they could go on the US market. The FDA received authority to regulate advertising of prescription drugs and to establish good manufacturing practices. The law required that all drugs introduced between 1938 and 1962 had to be effective. An FDA - National Academy of Sciences collaborative study showed that nearly 40 percent of these products were not effective. A similarly comprehensive study of over-the-counter products began ten years later.

qas: question: How many Americans were given the drug Kevadon?
answers: text: Over 20,000

question: When was the drug taken off shelves in Germany?
answers: text: November 1961

question: How many newborns were born with issues due to Kevadon?
answers: text: about 17

question: How was Kevadon distributed to doctors?
answers: text: under the guise of investigational use

question: Why was this drug pulled off shelves?
answers: text: association with grave congenital abnormalities

question: In what year was thalidomide banned in Germany?
answers: text: 1961

question: What adverse effect was thalidomide associated with?
answers: text: congenital abnormalities

question: Thalidomide was distributed in the USA by what name?
answers: text: Kevadon

question: About how many Americans received thalidomide in a supposed study?
answers: text: Over 20,000

question: How many newborn American babies were affected by thalidomide?
answers: text: 17

question: How many Americans were given the drug thalidomide?

question: When was the drug taken off shelves in the USA?

question: How many newborns were born with issues due to Germany?

question: How was Kevadon distributed to the USA?

question: Why was this drug put on shelves?
context: The firm continued to pressure Kelsey and the agency to approve the application—until November 1961, when the drug was pulled off the German market because of its association with grave congenital abnormalities. Several thousand newborns in Europe and elsewhere suffered the teratogenic effects of thalidomide. Though the drug was never approved in the USA, the firm distributed Kevadon to over 1,000 physicians there under the guise of investigational use. Over 20,000 Americans received thalidomide in this "study," including 624 pregnant patients, and about 17 known newborns suffered the effects of the drug.[citation needed]

qas: question: What law prohibited birth control?
answers: text: Comstock laws

question: When was Enovid first approved?
answers: text: 1960

question: What increased due to the availability of birth control?
answers: text: pre-marital co-habitation

question: In 1965, how many women were on the birth control pill?
answers: text: 6.5 million

question: Who created the first oral birth control?
answers: text: E.D. Searle and Co

question: Discussing contraception sometimes led to prosecution under what laws?
answers: text: Comstock laws

question: What was the name of the first oral contraceptive?
answers: text: Enovid

question: When did the FDA approve Enovid?
answers: text: 1960

question: By 1965, about how many American women were taking Enovid?
answers: text: 6.5 million

question: Birth control was prohibited in most countries before what war?
answers: text: second world war

question: What law prohibited severe pills?

question: When was Colton first approved?

question: What increased due to the availability of severe pills?

question: In 1965, how many women were on the severe pill?

question: Who created the first marriage control?
context: Prior to the second world war, birth control was prohibited in many countries, and in the United States even the discussion of contraceptive methods sometimes led to prosecution under Comstock laws. The history of the development of oral contraceptives is thus closely tied to the birth control movement and the efforts of activists Margaret Sanger, Mary Dennett, and Emma Goldman. Based on fundamental research performed by Gregory Pincus and synthetic methods for progesterone developed by Carl Djerassi at Syntex and by Frank Colton at G.D. Searle & Co., the first oral contraceptive, Enovid, was developed by E.D. Searle and Co. and approved by the FDA in 1960. The original formulation incorporated vastly excessive doses of hormones, and caused severe side effects. Nonetheless, by 1962, 1.2 million American women were on the pill, and by 1965 the number had increased to 6.5 million. The availability of a convenient form of temporary contraceptive led to dramatic changes in social mores including expanding the range of lifestyle options available to women, reducing the reliance of women on men for contraceptive practice, encouraging the delay of marriage, and increasing pre-marital co-habitation.

qas: question: Who received the Laser-Debakey Clinical Medical Research Aware?
answers: text: Endo

question: How much money did Merk make in 1995?
answers: text: over US$1 billion

question: How many patients received Zocor?
answers: text: 4,444

question: What study did Merk sponsor in 1994?
answers: text: Scandinavian Simvastatin Survival Study

question: What did the study reveal after 5 years?
answers: text: a 35% reduction in their cholesterol, and their chances of dying of a heart attack were reduced by 42%

question: What was the brand name of simvastatin?
answers: text: Zocor

question: Patients treated with Zocor had their cholesterol reduced by how much?
answers: text: 35%

question: How much did Zocor reduce the chance of dying from a heart attack?
answers: text: 42%

question: How much money did Merck make from sales of Zocor and Mevacor?
answers: text: over US$1 billion

question: Endo received what award in 2008?
answers: text: Lasker-DeBakey Clinical Medical Research Award

question: Who received the Zocor Research Reward?

question: How much money did Simvastatin make in 1995?

question: How many patients received Simvastatin?

question: What study did Merk sponsor in 2008?

question: What did the study reveal after 2 years?
context: In April 1994, the results of a Merck-sponsored study, the Scandinavian Simvastatin Survival Study, were announced. Researchers tested simvastatin, later sold by Merck as Zocor, on 4,444 patients with high cholesterol and heart disease. After five years, the study concluded the patients saw a 35% reduction in their cholesterol, and their chances of dying of a heart attack were reduced by 42%. In 1995, Zocor and Mevacor both made Merck over US$1 billion. Endo was awarded the 2006 Japan Prize, and the Lasker-DeBakey Clinical Medical Research Award in 2008. For his "pioneering research into a new class of molecules" for "lowering cholesterol,"[sentence fragment]

qas: question: What is a drug discovery?
answers: text: the process by which potential drugs are discovered or designed

question: Who is usually responsible for early stages of drug discovery?
answers: text: universities and research institutions

question: What is used to manipulate pathways?
answers: text: molecular biology or biochemistry

question: What is involved in drug discovery?
answers: text: isolating the active ingredient from traditional remedies or by serendipitous discovery

question: What focuses on metabolic pathways?
answers: text: biotechnology

question: What is the name of the process in which possible drugs are discovered?
answers: text: Drug discovery

question: What groups carry out most early drug discoveries?
answers: text: research institutions

question: What kind of technology studies the understanding and manipulation of disease states and pathogens?
answers: text: biotechnology

question: Most drugs have been found by isolating what from traditional remedies?
answers: text: active ingredient

question: What is a remedy discovery?

question: Who is usually responsible for early stages of remedy discovery?

question: What is used to manipulate institutions?

question: What is involved in remedy discovery?

question: What focuses on early-stage pathways?
context: Drug discovery is the process by which potential drugs are discovered or designed. In the past most drugs have been discovered either by isolating the active ingredient from traditional remedies or by serendipitous discovery. Modern biotechnology often focuses on understanding the metabolic pathways related to a disease state or pathogen, and manipulating these pathways using molecular biology or biochemistry. A great deal of early-stage drug discovery has traditionally been carried out by universities and research institutions.

qas: question: How much does it cost to develop a new drug?
answers: text: about 1.3 billion

question: How many approvals of new drugs happen every year?
answers: text: averaged 22.9 approvals

question: Who is responsible for approval or rejection of new drugs?
answers: text: Center for Drug Evaluation and Research

question: How many drugs were approved in 2007?
answers: text: 18 approvals

question: Who reported the stable average rate in 2012?
answers: text: Professors Light and Lexchin

question: What does NMEs stand for?
answers: text: New Molecular Entities

question: How many pharmaceutical drugs were approved on average since 2001?
answers: text: 22.9

question: What is the approximate cost of developing a new drug, including the costs of failure?
answers: text: 1.3 billion USD

question: What has been the stable approval rate of new drugs?
answers: text: 15 to 25

question: How much does it cost to develop approvals?

question: How many approvals of new centers happen every year?

question: Who is responsible for approval or rejection of centers?

question: How many drugs were approved in 2012?

question: Who reported the stable average rate in 2007?
context: Drug discovery and development is very expensive; of all compounds investigated for use in humans only a small fraction are eventually approved in most nations by government appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001, the Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials, as well as a commitment to ongoing safety monitoring. Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account, the cost of developing a successful new drug (new chemical entity, or NCE), has been estimated at about 1.3 billion USD(not including marketing expenses). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades.

qas: question: What drugs are the least expensive to develop?
answers: text: those based on re-formulation of an existing active ingredient

question: What accounts for nearly half of the costs to develop drugs?
answers: text: opportunity cost of investing capital

question: What is the consequence in the value chain?
answers: text: increasingly outsource risks related to fundamental research

question: What happens when companies outsource?
answers: text: somewhat reshapes the industry ecosystem with biotechnology companies

question: What is re-formulations of active ingredients referred to?
answers: text: Line-extensions

question: Investing capital can increase drug development costs by how much?
answers: text: nearly half the total expense

question: What kind of companies have had a more important role in drug development?
answers: text: biotechnology

question: What firms tend to outsource drug development?
answers: text: major pharmaceutical multinationals

question: What drugs are the least fundamental to develop?

question: What accounts for nearly half of the costs to develop companies?

question: What is the consequence in the research chain?

question: What happens when companies approve drugs?

question: What is re-formulations of approved drugs referred to?
context: Some of these estimates also take into account the opportunity cost of investing capital many years before revenues are realized (see Time-value of money). Because of the very long time needed for discovery, development, and approval of pharmaceuticals, these costs can accumulate to nearly half the total expense. A direct consequence within the pharmaceutical industry value chain is that major pharmaceutical multinationals tend to increasingly outsource risks related to fundamental research, which somewhat reshapes the industry ecosystem with biotechnology companies playing an increasingly important role, and overall strategies being redefined accordingly. Some approved drugs, such as those based on re-formulation of an existing active ingredient (also referred to as Line-extensions) are much less expensive to develop.

qas: question: Why was Mevastatin never marketed?
answers: text: adverse effects of tumors, muscle deterioration, and sometimes death

question: Who discovered Mevastatin?
answers: text: Akira Endo

question: What is HMG-CoA responsible for producing?
answers: text: cholesterol

question: Where did Endo discover ML-236B?
answers: text: Penicillium citrinum

question: What was discovered in long term studies?
answers: text: too toxic for human use

question: In what year was mevastatin discovered?
answers: text: 1971

question: Who discovered mevastatin?
answers: text: Akira Endo

question: What organism produces mevastatin?
answers: text: Penicillium citrinum

question: What enzyme helps produce cholesterol?
answers: text: HMG-CoA reductase

question: Why was Penicillium never marketed?

question: Who discovered Penicillium?

question: What is Penicillium responsible for producing?

question: What was discovered in short term studies?

question: In what year was Penicillium discovered?
context: In 1971, Akira Endo, a Japanese biochemist working for the pharmaceutical company Sankyo, identified mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum, as an inhibitor of HMG-CoA reductase, a critical enzyme used by the body to produce cholesterol. Animal trials showed very good inhibitory effect as in clinical trials, however a long term study in dogs found toxic effects at higher doses and as a result mevastatin was believed to be too toxic for human use. Mevastatin was never marketed, because of its adverse effects of tumors, muscle deterioration, and sometimes death in laboratory dogs.

qas: question: How much did Pfizer settle the illegal marketing suit for?
answers: text: $301 million

question: What drugs were involved in cases of the largest criminal fines?
answers: text: Zyprexa, and the other involved Bextra

question: What was Pfizer accused of illegally marketing?
answers: text: Geodon

question: What companies have been involved with health care fraud cases?
answers: text: Bristol-Myers Squibb, Eli Lilly, Pfizer, AstraZeneca and Johnson & Johnson

question: What do illegal marketing cases fall under?
answers: text: False Claims Act

question: Firms such as Eli Lilly, Pfizer, and AstraZeneca have settled claims under what act?
answers: text: False Claims Act

question: Zyprexa was owned by what company?
answers: text: Eli Lilly

question: Pfizer was charged with illegally marketing what antipsychotic drug?
answers: text: Geodon

question: Pfizer settled the Geodon lawsuit for how much money?
answers: text: $301 million

question: How much did Eli Lilly settle the illegal marketing suit for?

question: What drugs were involved in cases of the largest Johnson & Johnson fines?

question: What was Johnson & Johnson accused of illegally marketing?

question: What companies have been involved with wrongdoing?

question: What do Johnson & Johnson marketing cases fall under?
context: Every major company selling the antipsychotics — Bristol-Myers Squibb, Eli Lilly, Pfizer, AstraZeneca and Johnson & Johnson — has either settled recent government cases, under the False Claims Act, for hundreds of millions of dollars or is currently under investigation for possible health care fraud. Following charges of illegal marketing, two of the settlements set records last year for the largest criminal fines ever imposed on corporations. One involved Eli Lilly's antipsychotic Zyprexa, and the other involved Bextra. In the Bextra case, the government also charged Pfizer with illegally marketing another antipsychotic, Geodon; Pfizer settled that part of the claim for $301 million, without admitting any wrongdoing.

qas: question: Who were some of the companies that encouraged the interactions between doctors and the pharmaceutical industry?
answers: text: World Economic Forum, the Gates Foundation, the Wellcome Trust, and the Food and Drug Administration

question: When did the article come out about the importance of interactions?
answers: text: May 2015

question: What was the reason behind these interactions?
answers: text: bring greater benefits to patients

question: What was believed to have created a financial conflict of interest?
answers: text: moral outrage over industry malfeasance

question: Who printed the article about the importance of interactions?
answers: text: New England Journal of Medicine

question: What publication had an article about the importance of pharmaceutical industry-physician interactions in 2015?
answers: text: New England Journal of Medicine

question: When was the editorial published?
answers: text: May 2015

question: Did major healthcare organizations support or discourage interactions between doctors and industries?
answers: text: encouraged greater interactions

question: Who were some of the companies that encouraged the interactions between doctors and the National Center for Advancing Translational Sciences of the National Institutes of Health?

question: When did the article come out about the importance of doctors?

question: What was the reason behind these conflicts?

question: What was believed to have created physician interactions?

question: Who printed the article about the importance of malfeasance?
context: In contrast to this viewpoint, an article and associated editorial in the New England Journal of Medicine in May 2015 emphasized the importance of pharmaceutical industry-physician interactions for the development of novel treatments, and argued that moral outrage over industry malfeasance had unjustifiably led many to overemphasize the problems created by financial conflicts of interest. The article noted that major healthcare organizations such as National Center for Advancing Translational Sciences of the National Institutes of Health, the President’s Council of Advisors on Science and Technology, the World Economic Forum, the Gates Foundation, the Wellcome Trust, and the Food and Drug Administration had encouraged greater interactions between physicians and industry in order to bring greater benefits to patients.

qas: question: Who conduced an investigation on doctors?
answers: text: ProPublica

question: Billions of dollars have been paid by which companies?
answers: text: AstraZeneca, Johnson & Johnson and Eli Lilly

question: How much was discovered to have been paid to doctors by drug companies?
answers: text: more than $500,000

question: What was the reason these companies have to pay fines?
answers: text: allegations that they paid doctors to promote drugs for unapproved uses

question: How many doctors have been paid by varies companies?
answers: text: at least 21

question: A ProPublica study found that some doctors were being paid how much money for speeches?
answers: text: more than $500,000

question: Half of the top earners were mostly in what field?
answers: text: psychiatry

question: Drug manufacturers paid off doctors a total of how much money?
answers: text: $2 billion

question: Who conducted an investigation on drugs?

question: Billions of drugs have been paid why which companies?

question: How much was discovered to have been paid to drug companies by doctors?

question: What was the reason these doctors have to pay fines?

question: How many companies have been paid by various doctors?
context: An investigation by ProPublica found that at least 21 doctors have been paid more than $500,000 for speeches and consulting by drugs manufacturers since 2009, with half of the top earners working in psychiatry, and about $2 billion in total paid to doctors for such services. AstraZeneca, Johnson & Johnson and Eli Lilly have paid billions of dollars in federal settlements over allegations that they paid doctors to promote drugs for unapproved uses. Some prominent medical schools have since tightened rules on faculty acceptance of such payments by drug companies.

qas: question: Why are collaborative agreements important?
answers: text: to explore the potential of new drug substances

question: How do large corporations show vertical integration?
answers: text: participating in a broad range of drug discovery and development, manufacturing and quality control, marketing, sales, and distribution

question: What are large companies relying on outside organizations for?
answers: text: to manage drug development

question: What are smaller organizations responsible for?
answers: text: focus on a specific aspect such as discovering drug candidates or developing formulations

question: What type of integration do large corporations often do?
answers: text: vertical

question: What type of integration do smaller organizations do?
answers: text: a specific aspect

question: What type of agreements are made to research potential new drugs?
answers: text: collaborative agreements

question: What type of organizations are multinational corporations increasingly rely on?
answers: text: contract research

question: Why is collaborative distribution important?

question: How do large corporations show multi-nationals integration?

question: What are large companies relying on outside marketing for?

question: What are smaller drugs responsible for?

question: What type of integration do large drugs often do?
context: Often, large multinational corporations exhibit vertical integration, participating in a broad range of drug discovery and development, manufacturing and quality control, marketing, sales, and distribution. Smaller organizations, on the other hand, often focus on a specific aspect such as discovering drug candidates or developing formulations. Often, collaborative agreements between research organizations and large pharmaceutical companies are formed to explore the potential of new drug substances. More recently, multi-nationals are increasingly relying on contract research organizations to manage drug development.

qas: question: Who is the core guide?
answers: text: The British National Formulary

question: Who is responsible for approving drugs in the United Kingdom?
answers: text: Medicines and Healthcare Products Regulatory Agency

question: After an approval in the United States, when does an approval occur in the United Kingdom and other countries?
answers: text: comes later

question: Who decides how NHS will allow drugs?
answers: text: National Institute for Health and Care Excellence (NICE)

question: Who does the evaluations for drugs in the United Kingdom?
answers: text: European Medicines Agency

question: What UK firm approves pharmaceutical drugs?
answers: text: Medicines and Healthcare Products Regulatory Agency

question: What UK organization evaluates drugs? 
answers: text: European Medicines Agency

question: What firm in England and Wales decides if the NHS allows drugs?
answers: text: National Institute for Health and Care Excellence

question: What is the name of the core guide for pharmacists and clinicians?
answers: text: British National Formulary

question: Who is the core clinician?

question: Who is responsible for approving drugs in the NHS?

question: After an approval in the UK, when does an approval occur in the NHS and other countries?

question: Who decides how the USA will allow drugs?

question: Who does the evaluations for drugs in the United States?
context: In the UK, the Medicines and Healthcare Products Regulatory Agency approves drugs for use, though the evaluation is done by the European Medicines Agency, an agency of the European Union based in London. Normally an approval in the UK and other European countries comes later than one in the USA. Then it is the National Institute for Health and Care Excellence (NICE), for England and Wales, who decides if and how the National Health Service (NHS) will allow (in the sense of paying for) their use. The British National Formulary is the core guide for pharmacists and clinicians.

qas: question: What is subject to the Orphan Drug Act?
answers: text: diseases involving fewer than 200,000 patients in the United States, or larger populations in certain circumstances

question: What is given to companies who develop drugs for "orphan diseases"?
answers: text: tax reductions, fee waivers, and market exclusivity on that drug for a limited time (seven years), regardless of whether the drug is protected by patents

question: Why are these companies rewarded?
answers: text: Because medical research and development of drugs to treat such diseases is financially disadvantageous

question: What is a term for rare diseases in some territories?
answers: text: orphan diseases

question: What size of disease populations are subject to the Orphan Drug Act?
answers: text: fewer than 200,000 patients

question: What is one financial benefit to researching orphan drugs?
answers: text: tax reductions

question: What is the length of time of market exclusivity of an orphan drug?
answers: text: seven years

question: What is subject to patients in the United States?

question: What is given to companies who develop rules for "orphan diseases"?

question: Why are these rules rewarded?

question: What is a term for rare rules in some territories?

question: What size of disease populations are subject to patents?
context: There are special rules for certain rare diseases ("orphan diseases") in several major drug regulatory territories. For example, diseases involving fewer than 200,000 patients in the United States, or larger populations in certain circumstances are subject to the Orphan Drug Act.  Because medical research and development of drugs to treat such diseases is financially disadvantageous, companies that do so are rewarded with tax reductions, fee waivers, and market exclusivity on that drug for a limited time (seven years), regardless of whether the drug is protected by patents.

qas: question: Who argued against regulators?
answers: text: Ben Goldacre

question: Who argued that drug regulators were greater serving the interests of the drug companies than the patients?
answers: text: Ben Goldacre

question: The business friendships between which parties have been criticized?
answers: text: regulator and company employees

question: Goldacre argued that which party didn't require that new drugs be improved at all?
answers: text: regulators

question: Who argued against the public?

question: Who argued that drug regulators were greater serving the interests of patients than the drug companies?

question: The business friendships between which parties have been praised?

question: The FDA argued that which party didn't require that new drugs be improved at all?

question: Who argues that regulators do not require that new regulators offer an improvement?
context: Ben Goldacre has argued that regulators – such as the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK, or the Food and Drug Administration (FDA) in the United States – advance the interests of the drug companies rather than the interests of the public due to revolving door exchange of employees between the regulator and the companies and friendships develop between regulator and company employees. He argues that regulators do not require that new drugs offer an improvement over what is already available, or even that they be particularly effective.

qas: question: NICE decides the availability of drugs in which two countries?
answers: text: England and Wales

question: What is the name of the organization in Scotland that decides the availability of drugs?
answers: text: Scottish Medicines Consortium

question: What threshold must a drug pass before it is approved?
answers: text: cost-effectiveness

question: QALY decides the availability of drugs in which two countries?

question: What is the name of the organization in Wales that decides the availability of drugs?

question: What threshold must a Wales pass before it is approved?

question: Where does QALY decide whether decide in what circumstances drugs and technologies will be made available?

question: What must the NHS do in order to be approved?
context: In many non-US western countries a 'fourth hurdle' of cost effectiveness analysis has developed before new technologies can be provided. This focuses on the efficiency (in terms of the cost per QALY) of the technologies in question rather than their efficacy. In England and Wales NICE decides whether and in what circumstances drugs and technologies will be made available by the NHS, whilst similar arrangements exist with the Scottish Medicines Consortium in Scotland, and the Pharmaceutical Benefits Advisory Committee in Australia. A product must pass the threshold for cost-effectiveness if it is to be approved. Treatments must represent 'value for money' and a net benefit to society.

qas: question: How much money did the top ten bestselling drugs make in 2013?
answers: text: $75.6 billion

question: What was the name of the top-selling anti-inflammatory drug in 2013?
answers: text: Humira

question: What was the bestselling drug in history?
answers: text: Lipitor

question: How much money did Lipitor make before the patent expired?
answers: text: $141 billion

question: In what year did Pfizer's patent over Lipitor expire?
answers: text: 2011

question: How much money did the top ten bestselling drugs make in 2011?

question: What was the name of the top-selling anti-inflammatory drug in 2011?

question: What was the bestselling drug in 2011?

question: How much money did Lipitor make after the patent expired?

question: In what year did Humira's patent over Lipitor expire?
context: The top ten best-selling drugs of 2013 totaled $75.6 billion in sales, with the anti-inflammatory drug Humira being the best-selling drug worldwide at $10.7 billion in sales. The second and third best selling were Enbrel and Remicade, respectively. The top three best-selling drugs in the United States in 2013 were Abilify ($6.3 billion,) Nexium ($6 billion) and Humira ($5.4 billion). The best-selling drug ever, Lipitor, averaged $13 billion annually and netted $141 billion total over its lifetime before Pfizer's patent expired in November 2011.

qas: question: How long do drug exclusivity rights usually last?
answers: text: 20 years

question: Governments grant permission to market drugs after how many years?
answers: text: 10 to 15 years on average

question: What enables a drug's owner to recover R&D costs?
answers: text: Patent protection

question: What kind of drug is produced by competitors once a patent expires?
answers: text: generic

question: What decade was the pharmaceutical industry's "golden era"?
answers: text: 1990s

question: How long do company exclusivity rights usually last?

question: Governments grant permission to market companies after how many years?

question: What enables a drug's owner to recover patent costs?

question: What kind of drug is produced by competitors once an industry expires?

question: What decade was the pharmaceutical industry's "drug era"?
context: Depending on a number of considerations, a company may apply for and be granted a patent for the drug, or the process of producing the drug, granting exclusivity rights typically for about 20 years. However, only after rigorous study and testing, which takes 10 to 15 years on average, will governmental authorities grant permission for the company to market and sell the drug. Patent protection enables the owner of the patent to recover the costs of research and development through high profit margins for the branded drug. When the patent protection for the drug expires, a generic drug is usually developed and sold by a competing company. The development and approval of generics is less expensive, allowing them to be sold at a lower price. Often the owner of the branded drug will introduce a generic version before the patent expires in order to get a head start in the generic market. Restructuring has therefore become routine, driven by the patent expiration of products launched during the industry's "golden era" in the 1990s and companies' failure to develop sufficient new blockbuster products to replace lost revenues.

qas: question: The safety and efficacy of new drugs must be approved by what organization in the US?
answers: text: Food and Drug Administration

question: What type of filing is used before beginning human trials?
answers: text: Investigational New Drug

question: How many phases of human trials may be done after IND approval?
answers: text: three

question: What type of application is filed after completing three phases of human trials?
answers: text: New Drug Application

question: What type of risk assessment results in approving the drug to go on the market?
answers: text: positive benefit-risk

question: What organization in the US must approve the safety and efficacy of testing?

question: What type of filing is used before beginning risk assessment?

question: How many phases of human trials may be done after review?

question: What type of application is filed after completing three phases of products?

question: What type of risk assessment results in approving the drug to go on to studies?
context: In the United States, new pharmaceutical products must be approved by the Food and Drug Administration (FDA) as being both safe and effective. This process generally involves submission of an Investigational New Drug filing with sufficient pre-clinical data to support proceeding with human trials. Following IND approval, three phases of progressively larger human clinical trials may be conducted. Phase I generally studies toxicity using healthy volunteers. Phase II can include pharmacokinetics and dosing in patients, and Phase III is a very large study of efficacy in the intended patient population. Following the successful completion of phase III testing, a New Drug Application is submitted to the FDA. The FDA review the data and if the product is seen as having a positive benefit-risk assessment, approval to market the product in the US is granted.

qas: question: "Drug reps" are usually hired by what type of firms?
answers: text: Pharmaceutical companies

question: What law regulates drug marketing in the US?
answers: text: Prescription Drug Marketing Act of 1987

question: Who do drug reps market to?
answers: text: directly and personally to physicians

question: "US reps" are usually hired by what type of firms?

question: What law regulates drug marketing in some countries?

question: Who do US reps market to? 

question: Who do US companies generally employ?

question: What is marketing of media in the US regulated by?
context: Advertising is common in healthcare journals as well as through more mainstream media routes. In some countries, notably the US, they are allowed to advertise directly to the general public. Pharmaceutical companies generally employ sales people (often called 'drug reps' or, an older term, 'detail men') to market directly and personally to physicians and other healthcare providers. In some countries, notably the US, pharmaceutical companies also employ lobbyists to influence politicians. Marketing of prescription drugs in the US is regulated by the federal Prescription Drug Marketing Act of 1987.

qas: question: Drug reps have been accused of giving what to health professionals?
answers: text: 'gifts' and biased information

question: Drug marketers have hired who as paid consultants?
answers: text: physicians

question: What publications can drug ads be commonly found?
answers: text: journals and conferences

question: What have drug reps been accused of giving to conferences?

question: Conferences have hired who as paid consultants?

question: What publications can advisory boards be commonly found in?

question: Who has been accused of influencing consultants?

question: What has stopped controversy?
context: There has been increasing controversy surrounding pharmaceutical marketing and influence. There have been accusations and findings of influence on doctors and other health professionals through drug reps, including the constant provision of marketing 'gifts' and biased information to health professionals; highly prevalent advertising in journals and conferences; funding independent healthcare organizations and health promotion campaigns; lobbying physicians and politicians (more than any other industry in the US); sponsorship of medical schools or nurse training; sponsorship of continuing educational events, with influence on the curriculum; and hiring physicians as paid consultants on medical advisory boards.