The identification of causative genetic variants for hereditary diseases has revolutionized clinical medicine and an extensive collaborative framework with international cooperation has become a global trend to understand rare disorders. The Initiative on Rare and Undiagnosed Diseases (IRUD) was established in Japan to provide accurate diagnosis, discover causes, and ultimately provide cures for rare and undiagnosed diseases. The fundamental IRUD system consists of three pillars: IRUD diagnostic coordination, analysis centers (IRUD-ACs), and a data center (IRUD-DC). IRUD diagnostic coordination consists of clinical centers (IRUD-CLs) and clinical specialty subgroups (IRUD-CSSs). In addition, the IRUD coordinating center (IRUD-CC) manages the entire IRUD system and temporarily operates the IRUD resource center (IRUD-RC). By the end of March 2021, 6301 pedigrees consisting of 18,136 individuals were registered in the IRUD. The whole-exome sequencing method was completed in 5136 pedigrees, and a final diagnosis was established in 2247 pedigrees (43.8%). The total number of aberrated genes and pathogenic variants was 657 and 1718, among which 1113 (64.8%) were novel. In addition, 39 novel disease entities or phenotypes with 41 aberrated genes were identified. The 6-year endeavor of IRUD has been an overwhelming success, establishing an all-Japan comprehensive diagnostic and research system covering all geographic areas and clinical specialties/subspecialties. IRUD has accurately diagnosed diseases, identified novel aberrated genes or disease entities, discovered many candidate genes, and enriched phenotypic and pathogenic variant databases. Further promotion of the IRUD is essential for determining causes and developing cures for rare and undiagnosed diseases. Identification of the causative genetic variants of hereditary diseases has revolutionized clinical medicine to enhance diagnostic accuracy, understand disease pathogenesis, and develop therapies. The major technical breakthrough behind the revolution was the development of whole-genome sequencing (WGS) and whole-exome sequencing (WES) methods employing next-generation sequencing (NGS), enabling identification of causative genetic variants by simultaneously capturing all candidate variants potentially causing diseases in affected individuals. Additionally, tremendous amounts of variant data have been generated using sequencers and remarkable advances have been made in bioinformatics exploiting such big data with powerful computational data analysis methods. Accumulation of variant data via registration in public databases has also accelerated the discovery of pathogenic variants by filtering known variants that are not associated with diseases.https://www.omim.org/), 9514 hereditary diseases were registered as of November 2021, of which 3288 diseases with (suspected) Mendelian basis are classified as having an unknown molecular basis. A complete understanding of the molecular basis of these diseases is one of the ultimate goals of human molecular genetics, which remains highly challenging even in the NGS era. The difficulty lies in identifying multiple pedigrees with pathogenic variants in the same genes to verify causality, particularly when researchers attempt to discover causative genetic variants for ultra-rare diseases, which are thought to comprise most unsolved diseases [However, there still remain many diseases for which causative genetic variants have not been identified. According to Online Mendelian Inheritance in Man (OMIM) (URL: https://irdirc.org/about-us/history/) established a worldwide network to connect individual projects to conduct international collaborative studies, further promoting the discovery of causative genetic variants [To solve the N-of-1 problem, the formation of extensive collaborative frameworks with international cooperation has become a global trend . The Undvariants . In 2015variants  and set variants . Furthervariants . One of variants . MME adovariants  and faciEven when causative genetic variants have been established, genetic diagnosis of rare diseases remains difficult in clinical settings. One reason for this is that a limited number of patients undergo WGS- or WES-based genetic diagnosis. Accessibility is among the key factors that can drive the utilization of this innovative technology in clinical genetics, necessitating a nationwide infrastructure to regionally equalize this testing. Additionally, determining pathogenic variants among a large number of variants yielded by WGS/WES and establishing the final diagnosis in which the pathogenic variants fully account for clinical manifestations is labor-intensive. Particularly, a substantial number of rare and undiagnosed diseases present with complex phenotypes with multiple affected organs, making the determination difficult by researchers in a single specialty. Therefore, it is recommended that diagnostic boards composed of physicians with a wide range of specialties and geneticists should discuss the final diagnosis based on the phenotypes and WGS/WES data.Enhancing the diagnostic accuracy of rare diseases has been vigorously pursued in Japan. Remarkable achievements have been made in the research and countermeasures for rare and intractable diseases, designated as “Nan-byo,” by the Ministry of Health, Labor and Welfare in Japan, which was established in 1972 after the subacute myelo-optic neuropathy endemic. In 2015, a new intractable disease law was enforced to expand “Nan-byo” from 56 to 333 diseases, further promoting the diagnosis of rare and intractable diseases. Nevertheless, two surveys conducted by AMED showed that more than 37,000 cases remained undiagnosed .To address these issues, the Initiative on Rare and Undiagnosed Diseases (IRUD) was launched in 2015 as a nationwide project in Japan supported by AMED . IRUD aiThe IRUD entry criteria are as follows .1. The patient remains undiagnosed for ≥6 months (not necessary for infants) and suffers from disabilities in daily life, AND2–1. Objective signs exist that cannot be attributed to a single organ; OR2–2. Direct or indirect evidence exists of a genetic etiology (e.g. similar symptom(s) found in the patient’s relatives) .Here, an undiagnosed disease is clearly distinguished from an undetermined disease in which a clinical diagnosis has been made but its causative genetic variants have not been confirmed. For example, if spinocerebellar degeneration is clinically diagnosed, although its causative genetic variants have not been analyzed and disease type has not been determined, it is classified as an undetermined disease and excluded from the IRUD. This clearly distinguishes the IRUD from genetic diagnostic services.https://annovar.openbioinformatics.org/) together with RefSeq (http://www.ncbi.nlm.nih.gov/RefSeq/), 1000 Genomes Project Database (http://www.1000genomes.org/), dbSNP135 (http://www.ncbi.nlm.nih.gov/projects/SNP/), gnomAD (http://www.gnomad.broadinstitute.org), and in-house databases.Blood samples were obtained from the participants fulfilling the criteria mentioned above with informed consent, DNA samples were extracted, and B-cell lymphoblast cell lines were established. Genomic DNA was subjected to enrichment of exonic sequences using Agilent SureSelect . Massively parallel sequencing (100-base pair paired-end reads) was performed using NGS . The sequences were aligned to the reference genome (GRCh37/hg19) using the Burrows-Wheeler Aligner or NovoAlign. Removal of potential polymerase chain reaction duplicates, recalibration of base quality values, local realignment, and variation calls were performed using SAMtools, Picard, and GATK with default parameter settings for alignment of raw reads and detection of single-nucleotide variants and short insertion/deletion variants. These variants were annotated using ANNOVAR  was established in IRUD-A as one of the leading model projects in AMED to facilitate the ethical review process in multi-institutional large-scale collaborative research. All but one of the individual institutional ethical committees in IRUD-A delegated the reviewing process to the CEC. The delegation process had been further promoted upon the integration of IRUD-A and IRUD-P.A unified research protocol for IRUD was reviewed and approved by the CEC. The ethics committee of individual institutions delegated the review process to the CEC, where approval of the protocol allowed each institute to initiate IRUD research based on the unified protocol. Amendment of the unified protocol, such as authentication of newly participating institutes, is accomplished in a one-step review process as an entire IRUD project. This study was approved by the CEC at Tohoku University on February 20, 2018 (CEC No. 2017-2-303).The most important achievement of IRUD is establishment of a unified all-Japan diagnostic and research system for rare and undiagnosed diseases covering entire geographic areas and clinical specialty/subspecialty fields. The IRUD system consists of three pillars: IRUD diagnostic coordination, analysis centers (IRUD-ACs), and a data center (IRUD-DC). IRUD diagnostic coordination consists of clinical centers (IRUD-CLs) and clinical specialty subgroups (IRUD-CSSs). In addition, the IRUD coordinating center (IRUD-CC) manages the entire IRUD system and temporarily operates the IRUD Resource Center (IRUD-RC) Fig. .Fig. 1InThe principal role of IRUD-CC is administration of the whole system through monthly IRUD-PB meetings as the highest decision-making organization. The constituents of IRUD-PB include representatives of the IRUD-CC , AMED (program officers) as the funding agency, IRUD-CLs, IRUD-CSSs, IRUD-ACs, and IRUD-DCs. IRUD-CC drafts a unified research protocol that is ratified by IRUD-PB and subjected to CEC, with the one-step approval process contributing to timely modification of the IRUD research. In addition, IRUD-CC monitors the progress of the entire research by conducting a regular survey. IRUD-CC also operates the sample and information logistics system described in detail in a subsequent section.IRUD-CL/SCL is the only contact site for patients with IRUD. Upon patient entry, parents are recruited so that trio analysis can be performed. IRUD-CL/SCL operates the IRUD Diagnostic Board (IRUD-DB), which manages the process from patient entry decisions to final diagnosis establishment. IRUD-SCLs are designed to fill the geographic gaps of IRUD-CLs, although no funding was provided. IRUD Cooperative Hospitals refer candidates for IRUD entry to IRUD-CL/IRUD-SCL. The IRUD-DB plays a central role in the regional diagnostic network with IRUD Cooperative Hospitals. The IRUD-DB is composed of pediatricians and physicians of various specialties/subspecialties for adults, clinical geneticists, genetic counselors, and data scientists. The IRUD protocol stipulates the participation of representative physicians from local medical associations in each IRUD-DB to promote regional cooperation.IRUD-DB holds regular meetings during which thorough pre-entry evaluation is conducted based on the clinical information described in a regular format on a ‘patient sheet’ to determine whether the candidate is suitable for IRUD entry and if sufficient investigation has already been completed, including whether clinical workups and available genetic tests such as chromosome analysis or gene-panel analysis have been performed. Similarly, post-analysis evaluation is conducted at the regular meetings to determine whether the pathogenic variant reported by IRUD-AC fully accounts for the clinical phenotypes leading to the final clinical diagnosis. In addition, the activities of the IRUD-DB include genetic counseling, further follow-up and reevaluation of the pedigree, public relations, and human resource development. Thus, IRUD-CL/SCL plays an essential role in the clinical aspects of the IRUD system.IRUD-CSSs are organized by assembling members of IRUD-DBs across entire IRUD-CLs according to their specialties/subspecialties. IRUD-CSSs support the activities of individual IRUD-DBs and provide professional advice based on their specialties/subspecialties for cases that cannot be resolved by IRUD-CLs alone.Thus, IRUD-CLs and IRUD-CSSs form the IRUD Diagnostic Coordination covering entire geographic areas and specialty/subspecialty fields in Japan.Each IRUD-CL/IRUD-SCL sends DNA samples via an outsourcing provider to a corresponding single IRUD-AC, which conducts comprehensive genomic analysis, identifies pathogenic variants, and reports to the IRUD-CL/IRUD-SCL via the IRUD-CC. When pathogenic variants are undetermined, further intensive research is conducted to identify novel aberrated genes/pathogenic variants using WGS, multi-omics analysis, and functional studies.IRUD-DC operates the IRUD Exchange, the data-sharing platform described above, promotes data sharing among IRUD researchers, and serves as a gateway to domestic and international collaboration. Phenotypic and genomic information has been accumulated to promote the establishment of new causative genetic variants and disease concepts. The IRUD Exchange is also used as a database to understand the overall epidemiological landscape of rare and undiagnosed diseases registered in the IRUD. All IRUD-CLs and IRUD-SCLs have a computer terminal for the IRUD-Exchange, and phenotypic and genotype data are transferred to IRUD-DC through a specific virtual private network to ensure security.IRUD-RC establishes a resource repository for clinical information and DNA samples/B cell lines and manages a utilization committee for examining the utilization of repositories. The IRUD-CC temporarily serves as the IRUD-RC, which is planned to be established as an independent facility assigned by AMED.IRUD-CC organizes a unified workflow to facilitate sample and information sharing among the IRUD-CLs/IRUD-SCLs, IRUD-ACs, and IRUD-CC and establishes a centralized repository in IRUD-RC Fig. .Fig. 2SaUpon entry into the IRUD, an individual identification (ID) number, composed of a three-alphabetical institutional code and five-digit numerical number, is allotted to each registrant, whose DNA/cell line samples, clinical information, and analysis results are handled with a specific ID. The workflow utilizes an outsourcing provider to extract genomic DNA samples and establish B lymphoblast cell lines. The genomic DNA samples are sent to the IRUD-ACs and IRUD-CC, and B lymphoblast cell lines are sent to the IRUD-CC. Each IRUD-CL/IRUD-SCL sends the samples to a specific IRUD-AC designated by IRUD-CC. Clinical information in the form of a ‘patient sheet’ is also sent to IRUD-ACs via an outsourcing provider. The analysis results and clinical information are sent from the IRUD-ACs to the IRUD-CC and reported to the corresponding IRUD-CLs. Clinical information is accumulated in the IRUD-DC through IRUD-Exchange from the IRUD-CLs. Text-based clinical data on the patient sheet delivered from the IRUD-CL/SCL via the IRUD-AC and analysis reports delivered from the IRUD-AC are also stored in the IRUD-CC. Genomic DNA samples and B lymphoblast cell lines are deposited in the IRUD-RC.In March 2021, the IRUD diagnostic system comprised 450 institutions consisting of 37 IRUD-CLs, 15 IRUD-SCLs, and 398 cooperative hospitals  Fig. . Among ties Fig.  . Particularly, approximately one-half of pedigrees with an established diagnosis possess unique aberrated genes. Importantly, such diseases are individually ‘ultra-rare’ but not as a whole, necessitating further vigorous endeavors to provide accurate diagnosis and develop therapeutic measures for individual ‘ultra-rare’ diseases.The IRUD has established an accurate diagnosis for a large number of patients and, in some cases, led to the use of specific therapies with positive effects . Pathogehttps://www.ncbi.nlm.nih.gov/clinvar/), LOVD (https://www.lovd.nl/), and MGeND (https://mgend.med.kyoto-u.ac.jp/) as well as disease databases such as OMIM and Orphanet (https://www.orpha.net/).The IRUD has had important impacts on basic research by identifying many novel aberrated genes, establishing novel disease entities, and detecting novel pathogenic variants in known aberrated genes. Disease-causing genes are the most reliable pathogenic molecules with greatest impact on the development, course and prognosis of the disease. Identification of these genes has led to an increased understanding of disease pathogenesis and identification of druggable seeds, promoting research of rare and undiagnosed diseases, common diseases, and human physiology. Furthermore, the IRUD has greatly contributed to genomic medicine by identifying a large number of novel pathogenic variants in known aberrated genes. Approximately two-thirds of the identified pathogenic variants were novel, supporting the indispensable role of the IRUD in genomic medicine in addition to its diagnostic services. Aggregation of phenotypic and pathogenic variant data can enrich variant databases such as ClinVar (https://www.matchmakerexchange.org/participants.html). The collaboration network provides a collective dataset spanning more than 150,000 cases from more than 11,000 contributors in 88 countries [A remarkable feature of the IRUD is the extensive data sharing through the IRUD Exchange, which has accumulated HPO-based phenotypic and genetic data to enable searches for similar cases automatically by pattern-matching algorithms and solving N-of-1 problems. The IRUD Exchange is compatible with MME and functions as a gateway to domestic and international collaborative networks. The IRUD is one of the principal eight nodes of international genomic research projects connected via the MME . Activities in the IRUD encompass entire fields of genome medicine or research, including phenotyping, genetic analysis, informatics, diagnosis, and counseling. Experiences in the IRUD would be of great help in individual career development. The IRUD also provides excellent educational opportunities for medical geneticists, genetic counselors, and data scientists. Therefore, the IRUD is not only a nationwide diagnostic and research system, but also a sustainable human resource development system in Japan.Notwithstanding the exhaustive WES, nearly 3000 pedigrees remained undiagnosed. Particularly, 313 pedigrees belonged to the N-of-1 category, for which discovery of another pedigree with the same candidate genes should be definitely necessary. Further promotion of international collaboration is the key to address the N-of-1 issue. On top of that, reasons for the undetermined causes are thought to include mosaicism, genomic alterations, gene regulation, and complex inheritance, all of which are difficult to capture by WES . To addrList of genes and number of novel and known pathogenic variantsNovel genes and phenotypes


Note that all the authors agree with the decision to retract this article. The Editor and the authors regret any inconvenience that this retraction will cause to the readership of the Journal.The Editor of


DOI: 10.1039/C5RA25870GRetraction of ‘CuS nanocrystal@microgel nanocomposites for light-regulated release of dual-drugs and chemo-photothermal synergistic therapy  The Royal Society of Chemistry hereby wholly retracts this RSC Advances article due to concerns with the reliability of the data in the published article.The TEM image in Fig. 1c contains duplicating features and inconsistencies within the image, which indicates that it has been manipulated.Given the significance of the concern about the validity of the data, the findings presented in this paper are no longer reliable.Jie Sun, Rijun Gui, Hui Jin, Na Li and Xiaojing Wang state that Fig. 1c has not been manipulated but have not been able to provide any satisfactory raw data to confirm its authenticity. The authors oppose the decision to retract.Signed: Laura Fisher, Executive Editor, RSC Advancesst September 2020Date: 21


The authors would like to make corrections to a recently published paper .In the original publication, the funder German Research Foundation (Deutsche Forschungsgemeinschaft), DFG FOR 2959, project-id: 409800133; grant number: DI 1757/2-1 to authors Jonas Lander and Marie-Luise Dierks was not included. The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. The original publication has also been updated.


The authors wish to make the following corrections to this paper :After the publication of the manuscript, the authors recognized an error in the second paragraph of Section 3.1. The Trial Demonstrated PCV13 Efficacy for Prevention of First Episodes of VT CAP, Nonbacteremic/Noninvasive VT CAP and VT IPD. In the published version, it was stated that “For VT CAP, NB/NI VT CAP, and VT IPD, respectively, PCV13 demonstrated similar efficacy in the mITT population for first VT episodes  and all VT episodes  [29].”To the correct version, as follows:“For VT CAP, NB/NI VT CAP, and VT IPD, respectively, PCV13 demonstrated similar efficacy in the mITT population for first VT episodes  and all VT episodes  .”The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. The original publication has also been updated.


The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused.Following the publication of this paper, it was drawn to the Editors’ attention by a concerned reader that one of the data panels shown for the cell invasion assays in Fig. 2D was strikingly similar to another data panel that had appeared in different form in another article by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere prior to its submission to


The authors regret that the figures throughout the article were incorrectly referenced. The correct references for each figure are described in The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


B. Eng., 2018, 154, 99–107, https://doi.org/10.1016/j.compositesb.2018.08.001.The authors regret that part of Fig. 1 and the Graphical Abstract were reproduced from a published article without appropriate acknowledgment. The reference to be included is Girão et al. have granted permission for part of their Fig. 1 to be used in “Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration”.Girão The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


The authors regret the Author Disclosure information was missing from the above-mentioned published article. The information is now reproduced below. The authors would like to apologise for any inconvenience caused.No conflict declared.


The authors regret that the name of one of the authors (Naeem F. Qusty) was shown incorrectly in the original article. In addition, the author contributions were incorrectly given. The corrected author list and contributions are as shown here.A. S. (Abdu Saeed): conceptualization, software, data curation, writing – review & editing. S. Y. Q. (Safaa Y. Qusti): conceptualization, supervision, writing – review & editing. R. H. A. (Rawan Hamdan Almarwani): methodology, investigation, experiment measurements, writing – original draft. E. J. J. (Ebtihaj J. Jambi): validation, writing – review & editing. E. M. A. (Eida M. Alshammari): validation, writing – review & editing. N. F. Q (Naeem F. Qusty): validation, writing – review & editing. M. J. B. : conceptualization, supervision, writing – review & editing. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


Maximilian Klein et al., CrystEngComm, 2015, 17, 2070–2073, https://doi.org/10.1039/C4CE02347A.Correction for ‘A 3-dimensional {4 The correct Schläfli symbol is {42·84}·{42·84} corresponding to a pts net.The authors regret an error in the assignment of the net descriptor. In the original paper, the Schläfli symbol was given as {4lvt should appear as pts, and the assignment of {42·84} is corrected to {42·84}·{42·84}.Throughout the paper, including the title, The authors apologise for this error and for any inconvenience caused to readers.The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


The authors regret that the following Patient Consent Statement was missing from the above article:Patient ConsentAll patients were informed that data can be used for research and QA purposes, and possibly used in scientific publications (anonymized).The authors would like to apologise for any inconvenience caused.


The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


Computational and Mathematical Methods in Medicine has retracted the article titled “Analysis of Anesthesia Effect of Dexmedetomidine in Clinical Operation of Replantation of Severed Finger” [ Finger”  due to cFollowing an investigation conducted by the Hindawi Research Integrity team , signifiThe authors do not agree to the retraction.


Erratum zu:Herzschr Elektrophys 202210.1007/s00399-022-00855-xIn der Originalversion des Beitrags stand der Hinweis zu Teil 2 im Untertitel. Dieser Hinweis wurde nun in den Haupttitel eingefügt.Der Originalbeitrag wurde korrigiert.


In Evolutionary Applications 15:12, for the article by Lamarins et al.  entitledAll authors contributed equally to the conceptualization of the ideas developed in this study, and to the initial review and synthesis of the literature. Hence, the first five authors  should be considered as co‐first authors, while the five last authors  should be considered as co‐senior authors. The doctoral students  wrote the first draft of this manuscript and designed the figures. A smaller group  took on the second literature survey required by the reviewers. All authors reviewed, edited and approved the final manuscript. J.L and C.P were involved in the acquisition of funds.


Correction to: Behav Res10.3758/s13428-021-01759-3The authors report changes to Fig, 1 of this paper (below). ORCIDs and affiliations have also been updated.


The authors regret that the image used for Fig. 1e in the original manuscript was from an incorrect sample.The correct image is given here.The authors state that the findings and overall conclusions presented in the original article are unaffected by this change.The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


The symbols following their names originally appeared as follows:a Ding Ren,a,b,1Hui Liu,They now appear as follows:a,‡ Ding Ren,a,b,‡Hui Liu,Xiaojin Luo and Pingli Lu are the authors for correspondence. The symbols following their names originally appeared as follows:a,e,1 and Pingli Lua,b,1Xiaojin Luo,They now appear as follows:a,e,* and Pingli Lua,b,*Xiaojin Luo1 to *. The superscript appearing before the line “These authors contributed equally to this work” has been changed from 1 to ‡.Additionally, the superscript appearing before the addresses for correspondence has been changed from We apologize to the authors for the errors above.


DOI: 10.1039/C6RA12414C.Correction for ‘Facile preparation of novel quaternary g-C The authors regret that incorrect images were used in Fig. 2i (page 106575) and Fig. 3b (page 106576). The correct images are shown below.3N4/Fe3O4/AgI/Bi2S3 (30%) nanocomposite.Fig. 2i. EDX mapping of the g-C3N4/Fe3O4/AgI/Bi2S3 (30%) nanocomposite.Fig. 3b TEM image of the g-CThe Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


Prod. Rep., 2022, 39, 1438–1464, https://doi.org/10.1039/D2NP00003B.Correction for ‘Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae’ by Paul D. Fiesel  The authors regret that the acylation positions on the sugar backbone of the acylsugars depicted in The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


Retraction Note: J Ovarian Res 9, 57 (2016)10.1186/s13048-016-0266-3The Editor-in-Chief has retracted this article. After publication, the authors informed the journal that the associated data and documents were lost to technical issues. Therefore, the authors are no longer able to provide the raw data or evidence of ethics approval and patient consent.None of the authors have responded to any correspondence from the editor or publisher about this retraction notice.


The authors of “Revision Total Knee Arthroplasty Using Robotic Arm Technology”  would liWe have reviewed the article by Steelman et al  and openMatthew Bullock is a paid presenter for Smith & Nephew; is an unpaid consultant for Osso VR; has stock in Stryker; received educational support from Stryker, Smith & Nephew, Depuy, and Zimmer/Biomet; is a part of Editorial Board Arthroplasty Today; is a board member of AAKHS Patient Education Committee and West Virginia Orthopaedic Society Education Committee. The other authors declare no potential conflicts of interest.https://doi.org/10.1016/j.artd.2022.101091.For full disclosure statements refer to


The authors regret that in the above-stated article, the number and percentage of people taking vitamin D in the placebo group was incorrectly listed as “3 (80.5)” in Table 1. The correct number and percentage are “33 (80.5).”The authors would like to apologize for any inconvenience caused.


Journal of Healthcare Engineering has retracted the article titled “Clinical Efficacy and Safety of Percutaneous Spinal Endoscopy versus Traditional Open Surgery for Lumbar Disc Herniation: Systematic Review and Meta-Analysis” [nalysis”  due to cFollowing an investigation conducted by the Hindawi Research Integrity team , signifiThe authors do not agree to the retraction.


Computational Intelligence and Neuroscience has retracted the article titled “Nomogram to Predict Overall and Cancer-Specific Survival in Patients with Synovial Sarcoma in the Extremities: A Population-Based Study” [d Study”  due to cFollowing an investigation conducted by the Hindawi Research Integrity team , signifiThe authors do not agree with the retraction.


The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused.Following the publication of this paper, it was drawn to the Editors’ attention by a concerned reader that certain of the data shown for the cell invasion assays in Figs. 4D and 5D were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to


Journal of Healthcare Engineering has retracted the article titled “Application of Rapid Rehabilitation Nursing in Thoracic Surgery Nursing” [Nursing”  due to cFollowing an investigation conducted by the Hindawi Research Integrity team , signifi


The authors regret that that the title of their published work requires an update. While we utilized the term “placebo-controlled” in our original title and methods, we believe that “active-controlled” trial more accurately describes the design of our study. Subjects randomized to the control arm received a fractionated dose of intradermal IPV without the mucosal adjuvant (dmLT) under study, making their designation as a placebo arm inappropriate. This is an important distinction which we feel significantly impacts both interpretation of the resultant data and any conclusions of the study. We apologize that this was not noticed prior to publication and the revised title is now reproduced above.The authors would like to apologise for any inconvenience caused.


This article has been retracted: Oncotarget has completed its investigation of this paper. We found that Figures 2C, 2E, 6B, and 6F contain similarities with data appearing in other articles by different authors. The data had already been published elsewhere, or were already under consideration for publication prior to submission to Oncotarget. On June 15, 2022 Oncotarget received a signed letter asking to retract the paper because certain experiments, including cell colony formation and in vivo assay, were unable to be reproduced. Oncotarget has notified the affiliated institution regarding this retraction.2825-2834. https://doi.org/10.18632/oncotarget.13747Original article: Oncotarget. 2017; 8:2825–2834.


This abstract has been withdrawn.


Correction to: Eur J Nucl Med Mol Imaging (2022) 49:632–651https://doi.org/10.1007/s00259-021-05603-wThe authors regret a typo in the units assessing hyperglycaemia, which should be defined as > 8.9 mmol/L, and not as erroneously mentioned in the published version as > 8.9 nmol/L.


Table


In this article, the authors assess the clinical presentation of patients with urethral cuff erosion after the implant of an Artificial Urinary Sphincter (AUS) and also attempt to establish risk factors in this patient population   . As wel


In


The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused.Following the publication of this paper, it was drawn to the Editors’ attention by a concerned reader that certain of the data shown for the cell migration and invasion assays in Figs. 2C and 4C were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to


The Editors-in-Chief would like to alert readers that concerns have been raised regarding the data in this article . SpecifiNone of the authors have responded to any correspondence from the editor or publisher about this Editorial Expression of Concern.


The revised version of


In the original publication , there wThe correct title appears below.n) with records of ARD-T, and lung and ovarian cancer in the 29 municipalities (H-ASB) and for all Brazilian municipalities, 2000–2017.Table 1. Number of deaths (In the original publication , there wThe authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. The original publication has also been updated.


In the version of this article initially published, there were errors resulting from merged authors’ names. The following sentences highlight the errors and the corrected details:1 Abayomi Fadeyi, 2 Adekunle Olatayo Adeoti, 3 Muhammed Akanbi Nurudeen Adeboye, 4 Joseph Abioye Awosanya, 5 Ibironke Omowumi Oluwadiya, 6* Kehinde Sunday Oluwadiya.Should read:1Fadeyi Abayomi, 2 Adeoti Adekunle Olatayo, 3Adeboye Muhammed Akanbi Nurudeen, 4Awosanya Joseph Abioye, 5Oluwadiya Ibironke Omowumi, 6*Oluwadiya Kehinde Sunday.


In the initially published version of our article, we recently realized that there are errors in several figures and Table 2 due to misplace of images and data. The corrections are provided below.Finally, the author list in the paper should be updated as above in this erratum.The correction does not change the overall conclusions of this paper. We apologize for the error and for any inconvenience that may cause to the readers and the editors of this journal.


To the Editors:We read with interest the recent paper in your journal by Holzmann‐Littig and colleagues entitled “Estimating serum‐ionized magnesium concentration in hemodialysis patients”.ion is methodologically challenging and cost‐intensive in clinical practice.”.In the introduction, the authors state that “…accurate measurement of MgThe authors are to be commended for the work involved in developing and validating this formula. The authors state that “An equation containing three variables performed well both in terms of accuracy to estimate the ionized value and to predict normomagnesemia.” However, this formula has only been found to be 84% accurate in the external validation cohort, with an area under the curve (AUC) of only 0.78 for determining normomagnesemia.Both authors are employees of Nova Biomedical.


Furthermore, they apologise to the readership for any inconvenience caused.The authors have re-examined their data and realized that


The Margret M. and Paul B. Baltes Award Lecture will feature an address by the 2021 Baltes Award recipient, Laura B. Zahodne, PhD, of the University of Michigan. This session will also include the presentation of the 2022 Margret M. and Paul B. Baltes Award to recipient Eric S. Kim, PhD, of the University of British Columbia. The Margret M. and Paul B. Baltes Foundation Award in Behavioral and Social Gerontology recognizes outstanding early-career contributions in behavioral and social gerontology. The award is generously funded by the Margret M. and Paul B. Baltes Foundation.


Communications Biology 10.1038/s42003-021-02787-7, published online 19 November 2021.Correction to: An oversight was committed in neglecting to include several Malian co-authors who conducted the clinical study and provided samples for the study in the list of authors. This has now been corrected in the PDF and HTML versions of the Article.Corrected list of authors and affiliations:1, Justin Y.A. Doritchamou1, Bergeline C. Nguemwo Tentokam1, Robert D. Morrison1, Matthew V. Cowles1, Martin Burkhardt1, Rui Ma1, Almahamoudou Mahamar2, Oumar Attaher2, Bacary S. Diarra2, Moussa Traore2, Alassane Dicko2, Niraj H. Tolia1, Michal Fried1, Patrick E. Duffy1Jonathan P. Renn1 Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.2 Malaria Research and Training Center, University of Sciences, Techniques, and Technologies of Bamako, Bamako, Mali.


Sci., 2022, https://doi.org/10.1039/d2sc04846a.Correction for ‘ThC The authors regret that incorrect details were given for ref. 53 and 54 in the original article. The correct version of ref. 53 and 54 is given below.Phys. Rev. Lett., 1996, 77, 3865–3868.53. J. P. Perdew, K. Burke and M. Ernzerhof, Phys. Rev. Lett., 1998, 80, 891.54. J. P. Perdew, K. Burke and M. Ernzerhof, The authors also regret that there was an error in the sentence in lines 12–13 in the left column on page 5 of the original article. The text originally read, “The carbon lone pairs are even stronger donating, with 13% weight at thorium.” This sentence should read, “The carbon lone pairs are even stronger donating, with 14% weight at thorium.”The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


Paleomagnetism measures apparent polar wander (APW), continental motion relative to the magnetic pole, where APW = plate motion + true polar wander (TPW).  Although the authors rule in favor of plate motion, by their own admission: “That said, it is technically possible to ascribe all observed motions to two successive TPW events.” If the APW is instead due to TPW, then the Paleoarchean data have no bearing on ancient tectonics.Early plate tectonics is hotly debated, and paleomagnetic data can provide critical tests . BrennerTheir argument against TPW is that the two APW segments identified have orientations that differ by 48° to 90°, and “due to persistence in the geoid shape,” this is unlikely for TPW. Much of this difference derives from the structural rotation of the younger two poles from the same syncline relative to the rest of Pilbara. But the authors consider scenarios between 0 and 70° rotation because its magnitude is uncertain and may be zero. Without structural rotation, then the three poles exhibit an essentially continuous direction of polar motion, thus invalidating the empirical basis of their argument against TPW A.Assuming their preferred structural rotation of the young poles is correct, the two APW events are nearly orthogonal B. A signAPW speed is used to bolster their tectonic interpretation . The Pal


Following publication, concerns were raised regarding the integrity of the images in the published figures. The authors failed to provide a satisfactory explanation during the investigation, which was conducted in accordance with Frontiers’ policies.Given the concerns, the editors no longer have confidence in the findings presented in the article.During correspondence, the authors did not respond to the question of whether they agree or disagree to the retraction.This retraction was approved by the Chief Editors of Frontiers in Physiology and the Chief Executive Editor of Frontiers.


The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused.Following the publication of this paper, it was drawn to the Editors’ attention by a concerned reader that certain of the cell migration assay data shown in Fig. 2C were strikingly similar to data that had appeared in different form in another article by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere prior to its submission to


Scientific Data 10.1038/s41597-022-01292-8, published online 29 April 2022Correction to: Figure 2 of the paper was incorrect in the original version, with the labels for “Non-zero electric dipole” and “Zero electric dipole” switched around. This has been corrected in the HTML and pdf versions of the paper, which now indicates that “Non-zero electric dipole moment” sits within the Design principles for Rashba SS box on the right side of the figure, and “Zero electric dipole” sits within the Design Principles for Dresselhaus SS on the left, as the authors originally intended.


Journal of Healthcare Engineering has retracted the article titled “Application of Deep Learning Technology in Glioma” [ Glioma”  due to cFollowing an investigation conducted by the Hindawi Research Integrity team , signifi


Erratum zu:Herzschr Elektrophys 202210.1007/s00399-022-00917-0In diesem Artikel wurde Abb. Der Originalbeitrag wurde korrigiert.


The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused.Following the publication of the above paper, a concerned reader drew to the Editors' attention that the Transwell cell migration and invasion assay data shown in Fig. 3C appeared to overlap in a pair of the data panels within this figure; in addition, data that were strikingly similar to those included in this figure had already appeared in previously published papers written by different authors at different institutes. Moreover, there was an unexpected level of similarity regarding the control β-actin bands shown in the three western blot experiments in Fig. 4B, even though these experiments related to three different cell lines. Having considered the issues identified, the Editor of


The updated affiliation information can be seen in the affiliation part of this correction.“IFPDP-31-22” to “Mohammad Zubair Alam” was not included. The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. The original publication has also been updated.In the original publication , the funThe corrected Funding and Acknowledgment appear below:


Journal of Healthcare Engineering has retracted the article titled “Discipline Construction and Development of Medical Universities in Complex Environment under Digital Technology and Structural Equation Model” [n Model”  due to cFollowing an investigation conducted by the Hindawi Research Integrity team , signifiThe authors do not agree to the retraction.


The authors wish to make the following changes to their paper .F = 169.3, p < 0.001; Sham vs. HSI + Scramble, p < 0.001; Sham vs. HSI + Agomir-let-7i, p = 0.803; HSI + Scramble vs. HSI + Agomir-let-7i, p < 0.001) .’ has been amended to read ‘Next, we examined whether there are any expression changes in STING in agomir-let-7i-treated uninjured brains. Consistent with our expectations, a reduced STING mRNA expression level was observed in the hippocampi of agomir-let-7i-treated mice compared to scramble-treated mice F = 169.3, p < 0.001; Vehicle vs. Agomir-let-7i, p < 0.001; Vehicle vs. Scramble, p = 0.803; Scramble vs. Agomir-let-7i, p < 0.001) ’.In the text of this article initially published (PDF version), there were typing errors in the last paragraph of Page 10. The text originally reading ‘Next, we examined whether there are any expression changes in STING in agomir-let-7i-treated HSI brains. Consistent with our expectations, a reduced STING mRNA expression level was observed in the hippocampi of agomir-let-7i-treated HSI mice compared to scramble-treated HSI mice (Figures 3, 4 and 6 should be replaced. In the original publication, there were labeling errors in Figures 3 and 6. In Figure 3B, the labels ‘HIS + Scramble’ and ‘HIS + Agomir-let-7i’ were inadvertently swapped. The corrected In Figure 4A of the initially published article, the separate image of TUNEL staining in the HIS + Agomir-let-7i group was erroneously flipped horizontally. The error does not affect the conclusions reported in the paper. The corrected x-axis label, now reading ‘Vehicle’ and ‘Scramble’, initially appeared as ‘‘Control’ and ‘Agomir-NC’. In Figure 6E, the x-axis label, now reading ‘HIS + Scramble’ and ‘HIS + Agomir-let-7i’, initially appeared as ‘Stroke + Scramble’ and ‘Stroke + Agomir-let-7i’. In the Figure 6D caption, the text originally reading ‘the hippocampi of sham, scramble-treated and agomir-let-7i-treated HSI mice’ has been amended to read ‘the hippocampi of Vehicle-, scramble- and agomir-let-7i-treated uninjured mice’. The corrected In Figure 6D, the The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.


The authors are grateful to the interested reader for drawing this matter to their attention, and also apologize to the readership for any inconvenience caused.The authors have consulted their original data, and realize that errors were made with the semiquantification of the data; therefore, a revised version of


The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused.Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that various panels showing data from flow cytometric experiments in Figs. 2D and 5D were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article were already under consideration for publication, or had already been published, elsewhere when it was submitted to


Retraction to: Nature Communications 10.1038/s41467-020-17310-5, published online 15 July 2020The data in Fig. 3c did not originate from three biological replicates as claimed in the legend;In Figs. 3c and 5f, multiple lanes could not be matched back to the original raw data in the laboratory records;The GAPDH bands in Figs. 3c, 5f and 6e could not be matched with raw data;The LC-3B image in Fig. 5f was duplicated and rotated 180 degrees in Fig. 6e to represent p-AMPK (T172);In Fig. 7d, the 4X and 10X images did not originate from the same samples;In Fig. 7d, the 10X images of Mtb H37Rv + Ornithine and Mtb H37Rv + Imidazole contain overlap.The Editor has retracted this Article at the authors’ request. Following concerns from a reader, the authors initiated an internal investigation. After comparing the laboratory record and the figures, it was concluded that:Further data similarities have been identified in Figs. 2j and S1, as well as within Figs. S5, S10, S11 and S16. In light of these issues, the authors have requested to retract this Article.Ramya Sivangala Thandi has not responded to any correspondence from the editor or publisher about this retraction. All other authors agree to this retraction.


In addition, the spectra in the original figure do not match with the relevant discussion of 3N4, CaFe2O4 and CaFe2O4/g-C3N4/CNT composite. The correct image for The authors regret that mistakes were made during the preparation of The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


The stu


Journal of Healthcare Engineering has retracted the article titled “Discussion on Health Service System of Mobile Medical Institutions Based on Internet of Things and Cloud Computing” [mputing”  due to cFollowing an investigation conducted by the Hindawi Research Integrity team , signifi


DOI: 10.1039/D1RA04855D.Correction for ‘An indenocarbazole-based host material for solution processable green phosphorescent organic light emitting diodes’ by Eun Young Park  The authors regret that an incorrect version of The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


Correction: Mol Cancer 14, 10 (2015)https://doi.org/10.1186/s12943-014-0274-0; Published: 27 January 2015The Editor-in-Chief is issuing an editorial expression of concern to alert readers that this article shows signs of irregularities within the 1st and 4th image of VEGF in Figure 6G after this was highlighted by a reader. The Editor-in-Chief advises the readers to interpret the data with due caution. All authors agree to this Editorial Expression of Concern.


Journal of Healthcare Engineering has retracted the article titled “Clinical Study on the Relationship between the SNP rs8192675 (C/C) Site of SLC2A2 Gene and the Hypoglycemic Effect of Metformin in Type 2 Diabetes” [Following an investigation conducted by the Hindawi Research Integrity team , signifiThe authors do not agree to the retraction.


Abstract citation ID ckac131.313 has been removed


At the request of the authors, we report that in the paper published in the Sao Paulo Medical Journal, volume 137, issue number 6, DOI: 10.1590/1516-3180.2018.0370160919, page 550:Where it read:IPhD. Doctoral Student, Faculty of Industrial Management, Universiti Malaysia Pahang, Kuantan, Malaysia”“It should read:“PhD. Assistant Professor, Electrical Engineering Department, Institute of Business Management (IoBM), Karachi, Pakistan”


Furthermore, they apologize to the readership for any inconvenience caused.The revised version of


In view of the fact some of these data had already apparently been published previously, the Editor of Oncology Reports has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused.Following the publication of this paper, it was drawn to the Editors’ attention by a concerned reader that certain of the Transwell invasion assay data panels shown in Fig. 3A were strikingly similar to data appearing in different form in other articles written by different authors, but which had already been published elsewhere prior to this paper's submission to


Escherichia coli by random mutagenesis for improved lycopene’ by Hailin Chen et al., RSC Adv., 2018, 8, 15021–15028.Correction for ‘Directed evolution of mevalonate kinase in  Microbial Cell Factories,1 which should have been cited in this RSC Advances paper.The authors wish to draw the readers’ attention to their closely related paper, published in RSC Advances paper and RSC Advances article.The authors regret that there is unattributed overlap in text between this RSC Advances paper, a directed evolution strategy was used to optimize the activity of MK to enhance the tolerance for farnesyldiphosphate (FPP) and geranylgeranyldiphosphate (GGPP), to enhance the affinity of mevalonate and MK, and to improve lycopene production. The catalytic mechanisms of both enzymes are very different; however improving their activities can improve lycopene production.Two different rate-limiting enzymes in the lycopene synthetic pathway were studied using the same methods, mevalonate kinase (MK) in this paper and isopentenyl diphosphate isomerase (IDI) in The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused.Following the publication of this paper, it was drawn to the Editors’ attention by a concerned reader that the data in the centre panel shown for the cell invasion assays in Fig. 2C were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere prior to its submission to


National Science Review, Volume 10, Issue 1, 2023, https://doi.org/10.1093/nsr/nwac256). In the original published version of this manuscript, only Xiaotie Deng is listed as the corresponding author. The published manuscript has now been corrected to also include Ningyuan Li and Yaodong Yang as corresponding authors.Xiaotie Deng, Ningyuan Li and Yaodong Yang are corresponding authors of ‘On the complexity of computing Markov perfect equilibrium in general-sum stochastic games’ (


The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a satisfactory reply. The Editor apologizes to the readership for any inconvenience caused.Following the publication of this paper, it was drawn to the Editors’ attention by a concerned reader that certain of the cell migration and invasion assay data shown in Figs. 2C and 5C were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to


They also wish to apologize to the readership of the Journal for any inconvenience caused.The revised version of


The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper hence has issued an Expression of Concern to notify readers whilst the Editorial Office investigates. A duplicated, modified region has been identified between the miR-145 mimic and siHOXA1 panels of Figure 4C, as well as concerns raised regarding the western blots in Figures 6 and 7.


For this paper the corresponding author should be as indicated above. Additionally in the Acknowledgements section the following should have been included: We acknowledge support by Deutsche Forschungsgemeinschaft and Open Access Publishing Fund of Karlsruhe Institute of Technology.The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


Journal of Oncology has retracted the article titled “Identification of the Novel Methylated Genes' Signature to Predict Prognosis in INRG High-Risk Neuroblastomas” [astomas”  due to cFollowing an investigation conducted by the Hindawi Research Integrity team , signifiThe authors agree to the retraction.


Therefore, for the academic rigor of the paper, we modify Equation (8) to the correct form. The corrected Equation (8) appears below.There was an error in the original publication . In the The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. The original publication has also been updated.


Babesia microti is not transmitted transovarially. Babesia crassa-like agent has been found in I. persulcatus ticks in China rather than I. scapularis ticks. Several minor spelling and capitalization errors also were identified. There were two factual errors in the original publication of our manuscript  entitledThe authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.


Nucleic Acids Research, Volume 29, Issue 17, 1 September 2001, Pages 3539–3545, https://doi.org/10.1093/nar/29.17.3539In November 2021, a reader raised concerns about potential image manipulation in Figure 3A. The authors are unable to provide the original data generated more than 20 years ago. The editors and the authors’ institution have since examined the image, and the results were inconclusive. The editors advise readers to consider this image with care.Julian E. Sale and Barry L. StoddardSenior Executive Editors


Missing FundingThe authors wish to make the following correction to this paper .Missingthe supporter and funder, Italian Ministry of Health—Ricerca Corrente 2022, was not included. The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.In the original publication,


The authors would like to update the affiliations for Umair Umer and Syed Kazim Usman in the published publication . In addiThe authors state that the scientific conclusions are unaffected. The original publication has also been updated.


Journal of Healthcare Engineering has retracted the article titled “The Application of DOMS Mechanism and Prevention in Physical Education and Training” [raining”  due to cFollowing an investigation conducted by the Hindawi Research Integrity team , signifiThe authors do not agree to the retraction.


Gurzęda  The authors regret that the incorrect project number as financial support was included in the original article. The correct project number is 2015/17/B/ST8/00371.The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


The authors regret the error in Fig.


The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused.Following the publication of this paper, it was drawn to the Editors attention by a concerned reader that the western blotting assay data shown in Figs. 5B, 5E, 6C and 7A were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to


Correction to: Naunyn-Schmiedeberg's Archives of Pharmacology (2022) 395:867–88510.1007/s00210-022-02250-2We regret to inform readers that our paper  had mistakenly stated that tralokinumab “is administered via weekly subcutaneous injection” (p. 873). This should have read that tralokinumab “is administered as a loading dose, followed by subcutaneous injection every other week”. We apologize for any inconvenience this mistake may have caused.


Trianthema portulacastrum Linn. on dermal wounds via removal of oxidative stress and inflammation’ by Ekta Yadav et al., RSC Adv., 2018, 8, 21621–21635, https://doi.org/10.1039/C8RA03500H.Expression of concern for ‘Ameliorative effect of biofabricated ZnO nanoparticles of  RSC Advances is publishing this expression of concern in order to alert our readers that we are presently unsure of the reliability of the data reported in Fig. 3 of the article. A number of the wound healing images in Fig. 3 have been duplicated either within the figure, or in two of the authors' publications in Biomedicine & Pharmacotherapy.1,2The authors have provided a replacement figure for consideration and say that the new data does not affect the conclusions of the paper. The Royal Society of Chemistry has asked the affiliated institution to investigate this matter and establish whether the replacement images provided by the authors provide an accurate representation of the experiments that were conducted, and confirm the integrity and reliability of the new data provided. An expression of concern will continue to be associated with this manuscript until we receive information from the institution on this matter.Laura Fisherth January 202324RSC AdvancesExecutive Editor,


This article has been retracted: Aging has completed its investigation of this paper. We found overlap between some transwell assay images used for Figures 3G and 6E and data previously published by different authors. The authors confirmed the overlap and also raised a concern that the statistical methods used for some analyses were inappropriate. As a result, all of the listed authors agreed that the article should be retracted.The Administration of the First Affiliated Hospital of Xinxiang Medical University was notified about the retraction by Aging Journal. The Ethics Committee of The First Affiliated Hospital of Xinxiang Medical University agreed that this paper should be retracted because the errors in the statistical methods led to an insufficiently rigorous analysis of the results and because of the improper use of several pictures included in this manuscript. The authors deeply regret any inconvenience this publication has caused for the scientific community.


Following the publication of this article , concern○ Fig 4 left β-actin panel lanes 3 and 5, Fig 4 right β-actin panel lanes 3 and 5, and Fig 4 bottom β-actin panel lanes 1, 2, and 3.○ Fig 4 left β-actin panel lane 4, and Fig 4 right β-actin panel lanes 2 and 4.○ Fig 8 ACAT-2 panel lanes 2 and 4.○ Fig 9 β-actin panel lanes 1 and 5○ Fig 13A RXRα panel lanes 2 and 5.○ Figs 13A, 13B, 13C, 13D, 14B, and 14D GAPDH panels○ Fig 13B RXRβ panel lanes 1 and 4.○ Fig 13C LXRα panel lane 5 and Fig 13D LXRβ panel lane 1.○ Fig 14A PPARα lanes 1–2 and Fig 14C PPARγ lanes 4–5.○ Fig 14A and Fig 14C GAPDH panels.○ Fig 14B PPARβ panel lanes 2 and 5.○ Fig 14D SREBP2 panel lanes 1 and 4.The following results appear similar:○ Fig 2 NPY1R panel, between all lanes○ Fig 4 NPC1L1 panel, between lanes 2–3 and lanes 3–4.○ Fig 4 CD36 panel, between lanes 3–4.○ Fig 12 MTP panel, between lanes 3–4.○ Fig 13C LXRα panel, between lanes 4–5.○ Fig 14C PPARγ panel, between lanes 2–3.○ Fig 14D SREBP2 panel, between lanes 2–3.When levels are adjusted to visualize background, there appear to be vertical irregularities suggestive of splice lines in:The corresponding author states that the similarity between proteins is due to the stripping and re-probing of the same blot, and clarifies that some blots were spliced to remove extra lanes and/or duplicate or triplicate samples from the panel. The underlying data for the figures or concern are no longer available.PLOS ONE Editors retract this article.In light of the concerns affecting multiple figure panels that question the integrity of these data, the EG, CG and ED either did not respond directly or could not be reached. EL did not agree with the retraction.


The revised version of Experimental and Therapeutic Medicine for granting them the opportunity to publish this; furthermore, they apologize to the readership for any inconvenience caused.Note that this error did not have a major impact on either the overall results or on the conclusions reported in this study. The authors regret the errors that were made during the compilation of the data into


Bioscience Reports at the request of the Editor-in-Chief and the Editorial Board following receipt of a notification from a reader, alerting the Editorial Board to multiple similarities between the western blots of this manuscript and those of other articles. The GAPDH bands from Figure 3F are similar to those found in Fig. 6A A549/GAPDH from Wang et al. 2019 (doi: 10.1042/BSR20182433) and Fig. 4C AMC-HN-8/GAPDH from Li et al. 2019 (doi: 10.1042/BSR20181882). The authors have been contacted with regards to the retraction and have not responded to the Journal's queries or the concerns raised. Given the extent of the issues raised, the Editorial Board stand by the decision to retract the article.This article is being retracted from


Scientific Reports 10.1038/s41598-020-69192-8, published online 22 July 2020Retraction of: The Editors have retracted this Article. Following publication, concerns were raised about the rationale for the approach presented and the underlying reasoning. A post-publication review of the authors' mathematical arguments revealed a lack of clarity in the terms presented and inferences that are not adequately justified. The Editors therefore no longer have confidence in the conclusions presented.Muhammad Aslam and Khushnoor Khan do not agree to this retraction. Abdulmohsen Al Shareef did not respond to correspondence relating to this retraction.


The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an Expression of Concern to notify readers whilst the Editorial Office investigates. Duplications have been identified across multiple papers with no common authors. Figure panel 3b appears to be the same as Figure 3B of the article ‘Long noncoding RNA 00460 (LINC00460) promotes glioma progression by negatively regulating miR-320a’ (DOI: 10.1002/jcb.28232) and as Figure 3D  of the article ‘STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4’ (DOI: 10.1186/s12943-017-0680-1). The authors have been contacted with regards to these concerns.


A final reflection on the importance of evaluation aspects will be proposed at the end of the workshop.


Journal of Healthcare Engineering has retracted the article titled “The Clinical Effect of High-Flow Oxygen Therapy through the Nose on Patients with Acute Left Heart Failure and Hypoxemia” [poxemia”  due to cFollowing an investigation conducted by the Hindawi Research Integrity team , signifiThe authors disagree to the retraction.


Enterobacter faecalis MSI12 and its effect on the disruption of Candida albicans biofilm’ by G. Seghal Kiran et al., RSC Adv., 2015, 5, 71573–71585, DOI: 10.1039/C5RA10302A.Correction for ‘Characterization of an exopolysaccharide from probiont  The authors regret that incorrect versions of Accordingly, the experimental methods followed in the phase contrast microscopy and large-size images of The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


The authors wish to make a change to the author names  for this paper . Daskala1,*, Pierre-Christian Violet 2, Gustavo Vasquez 1, Katherine Belden 1, Michael Foster 3, Bret Mullin 3, Devon Magee 3, Isabelle Mikell 4, Lokesh Shah 4, Victoria Powers 4, Brian Curcio 5, Daniel Monti 6 and Mark Levine 2,*Dagan Coppock Author Contributions: P.-C.V., D.M. (Daniel Monti) and M.L. conceived the study; D.C., D.M. (Daniel Monti), M.L. and M.F. developed the trial methodology; D.C., G.V., K.B. and B.M. reviewed and enrolled subjects; D.C., D.M. (Daniel Monti), G.V. and K.B. provided clinical oversight and monitored safety; B.M., D.M. (Devon Magee), I.M., L.S. and V.P. were responsible for preparing and curating data; B.C. and D.C. performed formal analyses; D.C. and M.L. prepared the original manuscript draft; all authors reviewed and edited the manuscript; D.M. (Daniel Monti) acquired funding; D.C., D.M. (Daniel Monti) and M.L. supervised overall efforts. All authors have read and agreed to the published version of the manuscript.The “Author Contributions” statement thus should be updated to the following version:The second correction was the inclusion of the words “study-related” to the sentence: “There were no reported deaths in either arm.” This sentence has been changed to now read: “There were no reported study-related deaths in either arm.”The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.


Journal of Healthcare Engineering has retracted the article titled “Effect of Protein Nutrition Level on Protein Metabolism during Volleyball Exercise Based on Edge Computing in the Medical System” [ System”  due to cFollowing an investigation conducted by the Hindawi Research Integrity team , signifiThe authors do not agree to the retraction.


Pogostemon cablin Benth) using a microwave air-hydrodistillation method as a new green technique’ by Heri Septya Kusuma et al., RSC Adv., 2017, 7, 1336–1347.Expression of concern for ‘The extraction of essential oils from patchouli leaves ( RSC Advances is publishing this expression of concern in order to alert our readers that we are presently unsure of the reliability of the data reported in the article.Periodica Polytechnica Chemical Engineering, 2017, 61, 82–92), which has not been cited in this RSC Advances paper. The reproducibility seen between the GCMS data in these two papers is very unlikely. The authors have been unable to provide raw GCMS data for the measurements presented in the RSC Advances article.The Royal Society of Chemistry has been provided with credible information suggesting that the GCMS results presented in the paper may not be reliable. The majority of the microwave hydrodistillation (MHD) GCMS data presented in Table 5 has been reproduced from a previously published paper by the authors (The Royal Society of Chemistry is currently seeking support from the affiliated institution in order to investigate this matter and establish whether the reported results are reliable. An expression of concern will continue to be associated with this manuscript until we receive information from the institution on this matter.Andrew Shore19th November 2018RSC AdvancesExecutive Editor,


Lastly, the authors apologize to the readership for any inconvenience these errors may have caused.The corrected versions of


The authors regret that an incorrect grant number for B. Y. Chen was given in the original manuscript. The correct acknowledgements section is as shown below.The authors gratefully acknowledge the financial support provided by the Ministry of Science and Technology (MOST), Taiwan, under Grant No. MOST 104-2221-E-197-004-MY3 (S. H. Chang), 105-2221-E-002-047-MY3 (J. Z. Chen) and 106-2221-E-197-020-MY3 (B. Y. Chen).The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


In the original publication , a mistaThe authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.


Frontiers and Cell Development; due to our inattention, the citation [14] was not reported in the paper in Biology and should be added.In the original publication , there wThe authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.


Journal of Oncology has retracted the article titled “TMEM60 Promotes the Proliferation and Migration and Inhibits the Apoptosis of Glioma through Modulating AKT Signaling” [gnaling”  due to cFollowing an investigation conducted by the Hindawi Research Integrity team , signifiThe authors do not agree to the retraction.


The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused.Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the panels shown for the cell invasion assays in Figs. 2C and 6C were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had were already under consideration for publication prior to its submission to


In the published article in Additionally, in Fig. S7 (ESI), kidney slice pictures of control and GO groups and lung slice pictures of ssDNA-AgNPs and ssDNA-AgNPs@GO were duplicated. A revised version of the ESI has been published.The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


To the editor,We appreciate the editorial comments on our manuscript , 2. UnfoThe authors.


BMJ 2022;379:o2459, doi:10.1136/bmj.o2459) during editing. James Kigera and Siaka Sidibé were omitted and as a result the affiliations for many of the authors were also incorrect. The online version has been amended. We introduced errors in the author list of this editorial by Lukoye Atwoli and colleagues (


The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused.Following the publication of this paper, it was drawn to the Editors’ attention by a concerned reader that certain of the cell migration assay data shown in Fig. 2D were strikingly similar to data that had appeared in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to


The authors have retracted this article. After publication it came to the authors attention that there were issues with the quality of the data used in this study. The authors, therefore, no longer have confidence in the results or conclusions of this study. All authors agree to this retraction.


DOI: 10.1039/D1RA03207K.Correction for ‘Natural bamboo leaves as dielectric layers for flexible capacitive pressure sensors with adjustable sensitivity and a broad detection range’ by Zhihao Liu  The authors regret that an incorrect image was used for The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


The Editors-in-Chief have retracted this article because there are regions of overlap between Fig. 2A and Fig. 4A. The Editors-in-Chief therefore no longer have confidence in the data presented.Li Chen does not agree to this retraction. None of the other authors has responded to any correspondence from the publisher about this retraction.


Euglossa imperialis between April and June. However, this result is incorrect. After reanalyzing the differences between April and June in the amount of blends, the result is not significant .In the paper published by Arriaga‐Osnaya et al. , the autThe authors apologize for this oversight.


In the acknowledgements, the contract number (3000033429) was wrongly used instead of the fund number (MAUX1801) for the final funding body, and this last funder should read, Ministry of Business, Innovation and Employment Endeavour Fund of New Zealand (MAUX1801).The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


She completed her treatment (see Figure The authors declare they have no conflicts of interest.The photograph was taken with the patient's informed consent and in accordance with the declaration of HelsinkiThe authors received no specific funding for this work.Informed consent was obtained.


After a discussion with allof the authors, we have agreed on thefollowing changes to the original manuscript:The authors andaffiliations have been corrected as presented inthis Addition and Correction.The acknowledgments have beencorrected as follows: The authorsthank Dr. Rachael Simister for the technical assistance of matrixpolysaccharide analyses. The authors are grateful to Prof. Simon J.McQueen-Mason for the support at the Centre for Novel AgriculturalProducts (CNAP), University of York, York, U.K., and the Dixon laboratoryat University of North Texas for support with the lignin compositionalanalyses.The author contributions have been corrected as follows:Rosa AnaMalvar and Rogelio Santiago conceived of the study. Rogelio Santiago,Rosa Ana Malvar, and Ana López-Malvar participated in the experimentaldesign, carried out the field trials, and participated in sample collection.Ana López-Malvar carried out biochemical determinations andstatistical analysis. Ana López-Malvar wrote the draft. JaimeBarros-Rios and Leonardo D. Gómez assisted in biochemical analysisand Results and Discussion. Xose Carlos Souto contributed to the Resultsand Discussion. All authors read and approved the final manuscript.


Circular RNAs (circRNAs) are a new category of endogenous non‐protein coding RNAs (ncRNAs), and show the characteristics of high conservation, stability, and tissue specificity. Due to rapid advances in next‐generation sequencing and transcriptome profiling technologies, circRNAs have been widely discovered in many organisms and participated in the development and progress of a variety of diseases. As a type of molecular sponge, circRNAs mainly absorb micro RNAs competitively and interplay with RNA‐binding proteins to modulate the splicing as well as transcription of target genes.This review is based on a literature search using the Medline database. Search terms used were “circular RNAs and leukemia,” “circRNAs and leukemia,” “circRNAs and acute lymphoblastic leukemia,” “circRNAs and chronic lymphoblastic leukemia,” “circRNAs and acute myeloid leukemia,” “circRNAs and chronic myeloid leukemia,” and “circRNAs, biomarker, and hematological system.”CircRNAs have been proven as potential biomarkers and therapeutic targets in a variety of tumors. Recent research has found that circRNAs aberrantly exist in hematological cancers, especially leukemia, and are significantly associated with the incidence, progress, and metastasis of diseases as well as the prognosis of patients.The current work summarizes the latest findings on circRNAs in various types of leukemia, aiming to propose prospective therapies and new drug screening methods for the treatment of leukemia. The current work reviews the latest research on circular RNAs in various types of leukemia, aiming to provide promising therapeutic methods and novel drug screening strategies for leukemia. Depending on the extent of differentiation and maturation of leukemia as well as its progressive course, leukemia can be categorized into acute or chronic leukemia.2This review is based on a literature search using the Medline database. Search terms used were “circular RNAs and leukemia,” “circRNAs and leukemia,” “circRNAs and acute lymphoblastic leukemia,” “circRNAs and chronic lymphoblastic leukemia,” “circRNAs and acute myeloid leukemia,” “circRNAs and chronic myeloid leukemia,” and “circRNAs, biomarker, and hematological system.”3As a novel noncoding gene fragment, circRNAs participate in various biosynthetic courses as well as the occurrence of diseases. Compared with other linear RNA fragments, circRNAs do not have the 5′‐terminal cap structure or the 3′‐end polyA‐tail structure, instead, circRNAs are closed‐loop structures formed by covalent bonds.CircRNAs are primarily derived from protein‐coding exons, they are noncoding sequences formed via reverse shearing of pre‐mRNAs during transcription.CircRNAs are abnormally expressed in a variety of diseases. CircRNAs act as a “sponge” to specifically adsorb miRNAs, prevent them from binding to the target genes and thus inhibit target gene regulation.4CircRNAs are widely expressed in the whole blood, platelets, and exosomes in the hematological system.55.1AML belongs to a hematological malignancy featured with abnormal proliferation of immature myeloid cells, which affect the normal formation of bone‐marrow hematopoietic cells.CircRNAs exert key roles in AML. The dysregulation of circRNA expression may result from the abnormal damage in leukemia cells and participate in AML pathogenesis and the mechanism of chemotherapeutic resistance. circMYBL2 was found to exist more abundantly in AML patients carrying FLT3‐ITD mutations.APL is an uncommon type of AML featured with the formation of PML‐RARα fusion protein.5.2BCR‐ABL fusion gene and expression of the BCR‐ABL1 fusion protein,CML is a malignant myeloid proliferative tumor occurring in pluripotent hematopoietic stem cells with an annual incidence of 1−2 per 100,000 people.In addition to the BCR‐ABL fusion gene, there are also certain ncRNAs that regulate the transcription and translation of specific genes and participate in the progress of CML. The upregulation or downregulation of circRNAs takes an important part in assessing the prognosis, pathogenesis, and resistance to chemotherapeutic drugs of CML.5.3ALL is a common malignant tumor in childhood, most of which are genetically heterogeneous tumors induced by malignant proliferation of lymphoid progenitor cells with gene mutations, accompanied by varying degrees of development or differentiation arrest.5.4+ B lymphocytes in bone marrow, peripheral blood, spleen, and lymph nodes.CLL is a chronic lymphoproliferative disease of B cells, featured by the continuous accumulation of monoclonal CD5Current studies mainly focus on circRNAs originating from the nuclear genome, however, the biological and clinical properties of mitochondrial genome‐derived (mt) circRNAs remain sparsely characterized, particularly in CLL. Mc‐COX2, a kind of mt‐circRNA, was abundantly presented in CLL patient‐derived plasma exosomes and positively related to leukemogenesis and deteriorated condition in CLL patients.6Currently, the research on circRNAs has become a hot spot. CircRNAs can function as miRNA targets, transcription regulators, protein adapters, or protein translation factors, exerting numerous regulatory roles by sponging specific miRNAs. CircRNAs show high abundance and evolutionary conservation across species, characterized by tissue/cell‐specific expression. More importantly, circRNAs could be extensively detected in peripheral blood, presenting the feasibility as noninvasive biomarker. Therefore, circRNAs play latently important roles in the early diagnosis, prognostic evaluation, pathogenesis, and chemotherapeutic resistance of leukemia, as well as the proliferation, differentiation, and progression of leukemia cells.However, compared with other linear RNAs, the research on circRNAs is still very limited, many problems need to be solved before their application in preclinical and clinical studies. For example, the current approaches for quantifying circRNAs have shown certain limitations that restrain the development of clinically applicable quantitative assays. A recent study analyzed the expression profile of circRNAs in several B cell malignancies via high‐throughput RNA‐seq, and quantified multiple differentially expressed circRNAs by NanoString technology.Deng Wei: conceived, prepared, and revised the manuscript. Deng Wei, Chao Rong, and Zhu Shengdong: made the data acquisition and interpretation. All authors approved the final manuscript for publication.The authors declare no conflict of interest.


Sci., 2022, https://doi.org/10.1039/d2sc04969d.Correction for ‘An exchange coupled  During the editorial production of the finished article, the graphics associated with The intended version of The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


The authors regret their names were incorrectly published. This has been corrected as above. The authors would like to apologise for any inconvenience caused.


Journal of Healthcare Engineering has retracted the article titled “CircRNA RERE Promotes the Oxidative Stress-Induced Apoptosis and Autophagy of Nucleus Pulposus Cells through the miR-299-5p/Galectin-3 Axis” [-3 Axis”  due to cFollowing an investigation conducted by the Hindawi Research Integrity team , signifiThe authors do not agree to the retraction.


Pseudokirchneriella subcapitata by Monte Carlo approach’ by Shahram Lotfi et al., RSC Adv., 2022, 12, 24988–24997, https://doi.org/10.1039/D2RA03936B.Correction for ‘Ecotoxicological prediction of organic chemicals toward  The authors regret the omission of one of the co-corresponding authors’ email addresses from the original manuscript. The corrected email addresses are shown below.The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


Had we been aware of this important prior work,we certainly would have referenced it. For this reason we are nowpublishing this minor correction so the prior article is properlycited and the two articles in the record (and on indexing services)are more transparent to the community.Near the time of the submissionof our now published manuscript


The given name and family name of all the authors were reversed in the original version of the publication. It has been corrected with this erratum.


DOI: 10.1039/C9RA08707ACorrection for ‘Boron-doped few-layer graphene nanosheet gas sensor for enhanced ammonia sensing at room temperature’ by Shubhda Srivastava  The authors regret that affiliation b was incorrectly provided as Academy of Scientific and Innovative Research (AcSIR), CSIR-National Physical Laboratory Campus, Dr K S Krishnan Road, New Delhi 110012, India.The correct details are provided in the Affiliations section of this document.The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


To solve the problem of inflexibility of offline hand–eye calibration in “eye-in-hand” modes, an online hand–eye calibration method based on the ChArUco board is proposed in this paper. Firstly, a hand–eye calibration model based on the ChArUco board is established, by analyzing the mathematical model of hand–eye calibration, and the image features of the ChArUco board. According to the advantages of the ChArUco board, with both the checkerboard and the ArUco marker, an online hand–eye calibration algorithm based on the ChArUco board is designed. Then, the online hand–eye calibration algorithm, based on the ChArUco board, is used to realize the dynamic adjustment of the hand–eye position relationship. Finally, the hand–eye calibration experiment is carried out to verify the accuracy of the hand–eye calibration based on the ChArUco board. The robustness and accuracy of the proposed method are verified by online hand–eye calibration experiments. The experimental results show that the accuracy of the online hand–eye calibration method proposed in this paper is between 0.4 mm and 0.6 mm, which is almost the same as the offline hand–eye calibration accuracy. The method in this paper utilizes the advantages of the ChArUco board to realize online hand–eye calibration, which improves the flexibility and robustness of hand–eye calibration. The application of industrial robots has greatly improved the production efficiency and product quality of enterprises ,2. HowevCompared with the hand–eye calibration method based on the 3D calibrators, the hand–eye calibration method based on 2D images is more widely used. Since the feature points of the checkerboard pattern are easy to detect, most of the classical hand–eye calibration theories use it as the calibrator ,11,12. ITo solve these problems, an online hand–eye calibration method based on the ChArUco board is proposed in this paper. The ChArUco board is a combination of an ArUco marker and a checkerboard, and possesses the advantages of both. The ChArUco board rectifies the shortcomings of the ArUco marker’s poor positioning accuracy by using the high sub-pixel detection accuracy of the checkerboard corners of the calibration board, and solves the problem of the poor anti-interference of the checkerboard through the unique encoding of the ArUco marker. Based on the detection advantages of the ChArUco board, this paper designs a closed-loop feedback adjustment system for the robot to realize online hand–eye calibration of eye-in-hand mode.The other parts of the paper are arranged as follows: R and the translation vector t. The essence of hand–eye calibration was to solve the problem of AX = XB [The purpose of hand–eye calibration was to calculate the coordinate transformation relationship between the camera coordinate system, and the robot coordinate system, that is, to solve the rotation matrix  AX = XB ,18,19. HAs shown in Formula (2), the hand–eye calibration matrix could be solved through the calculation of the robot pose transformation, and the camera extrinsic parameters.Let According to the described mathematical model of hand–eye calibration, the solution process of hand–eye calibration needed to obtain the homogeneous matrix ArUco markers have the advantages of flexibility and easy detection. However, the ArUco marker has the problem that the detection accuracy of the edge corners is not high. Even if sub-pixel processing is performed on the corner, the expected accuracy is still not achieved. The black and white interlaced pattern of the checkerboard makes the corners easy to detect. Unfortunately, the flexibility of the checkerboard is not as extensive as the ArUco marker. When the checkerboard was used as a calibration object, the checkerboard needed to be completely visible, and could be blocked. The ChArUco board possessed the advantages of both the checkerboard and the ArUco marker. In addition, the ChArUco board ameliorated the deficiencies of both. As shown in As shown in In addition, the pose of each recognizable encoding pattern on the ChArUco board could be computed as if the pose of a single ArUco marker were recognized. Based on the detection advantages of the ChArUco board, this paper designed a closed-loop feedback adjustment system for the robot to realize online hand–eye calibration. As shown in n method . In addiIn this paper, Hikvision’s MV-CE050-30GM camera, FUJINON’s CF8ZA-1S lens and ABB’s IRB2600-20 robot were used to build the experimental platform. The experimental platform is shown in Before the experiment, the internal parameters of the camera used in the experiment were calibrated. The calculation results of camera internal parameters were as follows:In this paper, 10 sets of hand–eye calibration independent experiments were carried out, and 25 sets of hand–eye calibration data, based on the ArUco marker, the checkerboard and the ChArUco board, were collected in each experiment. The calculation results of camera extrinsic parameters for the three calibration methods are shown in In online hand–eye calibration experiments based on the ChArUco board, 10 sets of online hand–eye calibration independent experiments were carried out. In a single set of independent experiments, 25 sets of robot teaching actions were set, and the ChArUco board was placed away from the center of the camera’s field of view. In addition, as shown in Based on the above experimental results, it can be seen that the online hand–eye calibration method proposed in this paper could effectively solve the problem of online hand–eye calibration, and had good performance in robustness and accuracy.In order to reflect the practicability of this method, the performance of this method was compared with the existing methods, and the results are shown in Aiming at the problem of inflexible offline hand–eye calibration in eye-in-hand mode, an online hand–eye calibration method based on the ChArUco board was proposed in this paper. The method in this paper utilized the advantages of the ChArUco board, which has the advantages of high sub-pixel recognition accuracy of the checkerboard corner, and the strong flexibility of the ArUco marker, to realize the positioning of the calibration board. The position relationship between the calibration board and the robot was established. Then, the closed-loop feedback automatically adjusted the robot by detecting the position of the ChArUco board in the image. Enough hand–eye calibration data were collected by robot automatic control to complete online hand–eye calibration. In this paper, the accuracy of hand–eye calibration based on the ChArUco board was verified by comparative experiments. The robustness and accuracy of the method were verified by online hand–eye calibration experiments.In the current research of this paper, the influence of the hand–eye calibration caused by the robot motion error was not considered. In future work, we will study the influence of robot motion error on hand–eye calibration accuracy, and consider how to eliminate the influence of robot motion error. This will be an interesting and meaningful research direction.


Computational Intelligence and Neuroscience has retracted the article titled “LNCRNA XIST Inhibits miR-377-3p to Hinder Th17 Cell Differentiation through Upregulating ETS1” [Following an investigation conducted by the Hindawi Research Integrity team , signifi


There was an error in the original publication  in the fJ. Gen. Virol.2010, 91, 2341–2350.” (It has been changed to Ref. [112] in the updated version). The correct reference is “Rissanen, I.; Stass, R.; Zeltina, A.; Li, S.; Hepojoki, J.; Harlos, K.; Gilbert, R.J.C.; Huiskonen, J.T.; Bowden, T.A.; Sundquist, W.I. Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope. J. Virol.2017, 91.” . With this correction, the order of some references has been adjusted accordingly.In addition, there is an error in the reference for the following sentence: “The dissociation of the Gn/Gc complexes at a low pH is thought to make the tripartite fusion loop accessible for membrane fusion, although this dissociation does not seem to trigger membrane fusion and seems to even be reversible [39].” The reference here in the original publication is “Hepojoki, J.; Strandin, T.; Wang, H.; Vapalahti, O.; Vaheri, A.; Lankinen, H. Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.


All the authors agree to the publication of this corrigendum, and apologize to the readership for any inconvenience caused.The authors have re-examined their original data, and have realized that this figure was inadvertently assembled incorrectly owing to the similarity of the data shown in the two affected panels. The revised version of


Moreover, a universal reverse primer was used for the reverse primer of miR-15b-5p, as provided by the kit ; however, a different primer sequence used in the authors’ lab was erroneously written as the reverse primer of miR-15b-5p in the manuscript. Finally, note that the title was published with a typographical error: “miR-15p-5p” in the title should have been written as “miR-15b−5p”, as appeared elsewhere throughout the paper, and the corrected title is presented above.Following the publication of this article, an interested reader drew to the authors’ attention that the primer sequences written for lncRNA DQ786243 and miR-15b-5p on p. 2 in the study were incorrect. Upon requesting an explanation of these errors from the authors, they realized that, regarding the sequence of the reverse primer for lncRNA DQ786243, three nucleotides were omitted from its 3’-end . Regarding the primers of miR-15b-5p, the authors used the mature miR-15b-5p sequence as the forward primer; however, they inadvertently overlooked replacing U with T in the description of the forward primer of miR-15b-5p, and therefore the sequence of the forward primer of miR-15b-5p on line 27 should have been written as 5’-Molecular Medicine Reports for allowing them the opportunity to publish this corrigendum, and all the authors agree with its publication. The authors also regret the inconvenience that these mistakes have caused.The authors are grateful to the Editor of


In the original publication, errors were found in Figure 6D and Table S1. During statistics analysis, the Spearman analyze between PTPROt mRNA expression and γ-GT were misused with the data of ALT in Figure 6D and Table S1. The correct figures and table are shown below. The authors confirm that these corrections do not change the result interpretation or conclusions of the article. The authors are deeply sorry and sincerely apologize for any inconvenience or misunderstanding that may have caused.


Retraction Note: Stem Cell Research & Therapy (2021) 12:85https://doi.org/10.1186/s13287-021-02154-7The authors have retracted this article. After publication the authors noted that they used the incorrect β-actin protein expression data in Fig. 1E. Yao Fu did not participate in the experiments presented and were included in the author list without their permission. Meng Zhou, Yao Fu and Zi Wang agree to this retraction. Mingjiao Chen and Jin Li do not agree to this retraction.


The 1H NMR spectra show the appearance and disappearance of two of the characteristic peaks for 4-methylphenyl in the reactions to synthesise PEG–N–OH2 . Subsequently, the characteristic methyl peak of the macroinitiator (PEG–N–Br2) is also observed . The MALDI-TOF MS spectrum of the product of each reaction shows a set of peaks with a spacing of 44 m/z . The main peak position changes as the terminal group changes. The absolute molecular weight of each product obtained through MALDI-TOF MS matches well with the calculated molecular weight.The authors have added additional The electronic supplementary information (ESI) of the original article has been updated to reflect these changes.1H NMR spectrum, shown in In addition, the authors regret that the signal for the CH–Br group in the The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.


After having been in contact with the authors, they agreed with the decision to retract the paper. The Editor apologizes to the readership for any inconvenience caused.Subsequently to the publication of the above article, a concerned reader drew to the Editors' attention that the cell invasion and migration assay data shown in Fig. 3B and D were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that these contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to


PLOS ONE Editorial Board member. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.The Competing Interests statement for this article  is incomThe VSL#3 used in this study was obtained from VSL Pharmaceuticals and produced by Danisco/Dupont in the US.