EFFECT OF VITAMIN D LEVELS ON ASTHMA CONTROL IN ADULTS Astımlı Hastalarda D Vitamini Düzeyinin Astım Kontrolü Üzerine Etkisi
EFFECT OF VITAMIN D LEVELS ON ASTHMA CONTROL IN ADULTS Astımlı Hastalarda D Vitamini Düzeyinin Astım Kontrolü Üzerine Etkisi
Yazar: Çıftçı Küsbecı, Tuba; Argun Barış, Serap; Yıldız, Füsun; Baştığıt, İlknur; Boyacı, Haşim; Ilgaz, Ahmet
Dergi: Bozok Tıp Dergisi, Vol. 12 No. 4, 2022
Anahtar kelimeler: Health Care Administration ; Sağlık Kurumları Yönetimi ; EFFECT OF VITAMIN D LEVELS ON ASTHMA CONTROL INADULTS,Astımlı,Astımlı Hastalarda D Vitamini Düzeyinin Astım Kontrolü ÜzerineEtkisi ; EFFECT OF VITAMIN D LEVELS ON ASTHMA CONTROL INADULTS,Astımlı,Astımlı Hastalarda D Vitamini Düzeyinin Astım Kontrolü ÜzerineEtkisi

ABSTRACTObjective: The aim of this study is to evaluate the effects of serum vitamin D level and body mass index(BMI) on asthma control and pulmonary functions in asthmatic patients.Material and Methods: Thirty-five healthy normal controls and 60 patients with asthma were included inthe study between December 2016 and February 2017. At initial admission, demographic characteristicsand pulmonary function tests (PFT) were recorded and laboratory tests including serum vitamin D, calcium,phosphorus, parathormone and alkaline phosphatase levels were measured. Asthma control test (ACT) wasperformed to asthmatic patients. Fifty-three patients with asthma and 32 healthy controls with decreasedvitamin D level were consulted with Endocrinology Department for vitamin D replacement therapy. ACT andPFT were repeated after therapy at third month in asthmatic patients.Results: There were totally 95 individuals; 76 females (80%) and 19 males (20%), There were no significantdifference between age, gender and demographic characteristics between asthmatics and controlgroup. Smoking status and passive smoking rates were similar. There was no significant difference betweendaily sun exposure, calcium containing diet and menopausal status. Serum phosphorus, calcium, alkalinephosphatase, parathormone and 25-hydroxyvitamin D levels were similar in both groups. Vitamin levelswere low in about 90% of both groups. On the first admission, 71.7% of asthmatic patients were uncontrolled,while the rate of uncontrolled patients decreased to 13.2% after the post-replacement evaluation.There was a significant increase of ACT with respect to vitamin D replacement therapy (22.4 ± 2.7 vs 16 ±5.4, p=0.001). The mean BMI were high in both groups (≥30 kg/m²). The mean ACT score was lower in obeseasthmatics than in non-obese patients, but the difference was not significant (15.3 ± 5.4 vs. 17.5 ± 4.8, p=0.1). Presence of controlled or uncontrolled disease was similar between the obese and non-obese groups(p = 0.744).Conclusion: It is suggested that vitamin D replacement therapy had positive effects on asthma control andpulmonary functions but further multicenter, prospective studies with large number of cases are needed toevaluate the effect of vitamin D replacement therapy on these parameters.Keywords: Asthma; Vitamin D; Asthma Control Test (ACT); Pulmonary Function Test (PFT)

ABSTRACTObjective: The aim of this study is to evaluate the effects of serum vitamin D level and body mass index(BMI) on asthma control and pulmonary functions in asthmatic patients.Material and Methods: Thirty-five healthy normal controls and 60 patients with asthma were included inthe study between December 2016 and February 2017. At initial admission, demographic characteristicsand pulmonary function tests (PFT) were recorded and laboratory tests including serum vitamin D, calcium,phosphorus, parathormone and alkaline phosphatase levels were measured. Asthma control test (ACT) wasperformed to asthmatic patients. Fifty-three patients with asthma and 32 healthy controls with decreasedvitamin D level were consulted with Endocrinology Department for vitamin D replacement therapy. ACT andPFT were repeated after therapy at third month in asthmatic patients.Results: There were totally 95 individuals; 76 females (80%) and 19 males (20%), There were no significantdifference between age, gender and demographic characteristics between asthmatics and controlgroup. Smoking status and passive smoking rates were similar. There was no significant difference betweendaily sun exposure, calcium containing diet and menopausal status. Serum phosphorus, calcium, alkalinephosphatase, parathormone and 25-hydroxyvitamin D levels were similar in both groups. Vitamin levelswere low in about 90% of both groups. On the first admission, 71.7% of asthmatic patients were uncontrolled,while the rate of uncontrolled patients decreased to 13.2% after the post-replacement evaluation.There was a significant increase of ACT with respect to vitamin D replacement therapy (22.4 ± 2.7 vs 16 ±5.4, p=0.001). The mean BMI were high in both groups (≥30 kg/m²). The mean ACT score was lower in obeseasthmatics than in non-obese patients, but the difference was not significant (15.3 ± 5.4 vs. 17.5 ± 4.8, p=0.1). Presence of controlled or uncontrolled disease was similar between the obese and non-obese groups(p = 0.744).Conclusion: It is suggested that vitamin D replacement therapy had positive effects on asthma control andpulmonary functions but further multicenter, prospective studies with large number of cases are needed toevaluate the effect of vitamin D replacement therapy on these parameters.Keywords: Asthma; Vitamin D; Asthma Control Test (ACT); Pulmonary Function Test (PFT)