Fibroblastik/myofibroblastik benign ve lokal agresif neoplaziler ve nörofibromalarda DOG1 ekspresyon profili
Fibroblastik/myofibroblastik benign ve lokal agresif neoplaziler ve nörofibromalarda DOG1 ekspresyon profili
Yazar: Cansız Ersöz, Cevriye; Kankaya, Duygu; Kiremitçi, Saba; Kaygusuz, Gülşah
Dergi: Cumhuriyet Tıp Dergisi, Vol. 36 No. 2, 2014
Anahtar kelimeler: DOG1, neurofibroma, nodular fasciitis, desmoid tumor, dermatofibrosarcoma protuberans ; DOG1, nörofibroma, nodüler fasiit, desmoid tümör, dermatofibrosarkoma protuberans

ÖzetAmaç. Gastrointestinal stromal tümörlerde (GİST) spesifik olarak ekspresyon gösteren ve kalsiyum bağımlı klorid kanalı olarak bilinen DOG1, gastrointestinal stromal tümörlerin diğer sarkomlardan ayrımında kullanılan tanısal bir belirteçtir. Çeşitli araştırmalarda Gastrointestinal stromal tümor dışı mezenşimal tümörlerde değişen oranda DOG1 ekspresyonu bildirilmiştir. Bu çalışmada Nodüler fasiit, Nörofibroma, Desmoid tümör ve Dermatofibrosarkoma Protuberans olgularından oluşan bir vaka serisinde DOG1 ekspresyonu araştırılmıştır. Yöntem. Bu çalışmaya, Ankara Üniversitesi Tıp Fakültesi Tıbbi Patoloji Anabilim Dalı’nda 2005-2012 yılları arasında tanı almış Nodüler Fasiit (n=8), Desmoid tümör (n=8), Dermatofibrosarkoma Protuberans (n=8) ve Nörofibroma (n=8) vakaları dahil edilmiştir. Parafin bloklardan elde edilen kesitlerde otomatik immün boyama cihazı ile DOG1 çalışılmıştır. Bulgular. Yalnızca bir Nodüler fasiit olgusunda (1/8) fokal soluk sitoplazmik boyanma izlenirken, diğer olgularda DOG1 ekspresyonu saptanmamıştır. Sonuç. Fibroblastik /myofibroblastik benign ve lokal agresif neoplaziler ve nörofibromalarda DOG1’in tanısal değeri yoktur.Anahtar sözcükler: DOG1, nörofibroma, nodüler fasiit, desmoid tümör, dermatofibrosarkoma protuberans AbstractAim. DOG1 is a calcium-dependent chlorid channel, that shows specific expression in Gastrointestinal stromal tumors (GIST) can be used in differential diagnosis of these tumors with other soft tissue sarcomas. In several studies, DOG1 expression has been reported in varying proportions in Non-GIST mesenchymal tumors. In this study, we aimed to find the DOG1 expression profile in Nodular fasciit, Neurofibroma, Desmoid tumors and Dermatofibrosarcoma protuberans. Method. Nodular fasciit (n=8), Neurofibroma (n=8), Desmoid tumors (n=8) and Dermatofibrosarcoma protuberans (n=8) cases, diagnosed in Ankara University, Faculty of Medicine, Department of Pathology between 2005-2012, were included in this study. Results. Focal and pale DOG1 reactivity was seen only in one case of Nodular fasciit (1/8) whereas the remainig cases were negative with DOG1. Conclusion. DOG1 has no diagnostic value in benign and locally aggressive fibroblastic/myofibroblastic neoplasms and neurofibromas.Keywords: DOG1, neurofibroma, nodular fasciitis, desmoid tumor, dermatofibrosarcoma protuberans

Aim. DOG1 is a calcium-dependent chlorid channel, that shows specific expression in Gastrointestinal stromal tumors (GIST) can be used in differential diagnosis of these tumors with other soft tissue sarcomas. In several studies, DOG1 expression has been reported in varying proportions in Non-GIST mesenchymal tumors. In this study, we aimed to find the DOG1 expression profile in Nodular fasciit, Neurofibroma, Desmoid tumors and Dermatofibrosarcoma protuberans. Method. Nodular fasciit (n=8), Neurofibroma (n=8), Desmoid tumors (n=8) and Dermatofibrosarcoma protuberans (n=8) cases, diagnosed in Ankara University, Faculty of Medicine, Department of Pathology between 2005-2012, were included in this study. Results. Focal and pale DOG1 reactivity was seen only in one case of Nodular fasciit (1/8) whereas the remainig cases were negative with DOG1. Conclusion. DOG1 has no diagnostic value in benign and locally aggressive fibroblastic/myofibroblastic neoplasms and neurofibromas.