A LOOK AT THYROID FUNCTIONS AS A PREDICTOR ON PROGNOSIS OF CRITICALLY ILL PATIENTS IN INTENSIVE CARE UNITS FROM THE PERSPECTIVE OF COVID-19 Yoğun Bakım Ünitesindeki Kritik Hastaların Prognozunun Belirleyicisi Olarak Tiroid Fonksiyonlarına Covid-19 Perspektifinden Bir Bakış
A LOOK AT THYROID FUNCTIONS AS A PREDICTOR ON PROGNOSIS OF CRITICALLY ILL PATIENTS IN INTENSIVE CARE UNITS FROM THE PERSPECTIVE OF COVID-19 Yoğun Bakım Ünitesindeki Kritik Hastaların Prognozunun Belirleyicisi Olarak Tiroid Fonksiyonlarına Covid-19 Perspektifinden Bir Bakış
Yazar: Tümer, Murat; Bulut Yüksel, Nihal Deniz; Kılıçaslan, Banu; Akıncı, Seda Banu
Dergi: Bozok Tıp Dergisi, Vol. 14 No. 2, 2024
Anahtar kelimeler: Anaesthesiology ; Anesteziyoloji ; A LOOK AT THYROID FUNCTIONS AS A PREDICTOR ONPROGNOSIS OF CRITICALLY ILL PATIENTS IN INTENSIVECARE UNITS FROM THE PERSPECTIVE OF COVID-19,Yoğun Bakım Ünitesindeki Kritik Hastaların PrognozununBelirleyicisi Olarak Tiroid Fonksiyonlarına Covid-19,Perspektifinden Bir Bakış

ABSTRACTObjective: Thyroid gland can be affected both by cytokine storm and through angiotensin-convertingenzyme 2 receptors. A worse prognosis has been described in patients with low fT3 levels. The aim ofthis study is to evaluate the prognostic significance of thyroid function during COVID-ICU hospitalization.Material and Methods: After ethical approval, 100 COVID-19 patients followed in the ICU between March2020 and April 2021 was admitted to study. Patients with previous thyroid disease were excluded fromstudy. Free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) levels at ICUadmission were evaluated. Clinical, demographic, laboratory, treatment, and outcome data were obtainedfrom the patient's electronic hospital records. Mann Whitney U, Spearman correlation, binary logistic, andlinear regression tests were used for statistical analysis.Results: TSH was in 31 patients, fT3 was in 37 patients, and fT4 was in 54 patients, which were outside thenormal ranges. fT3 were lower in non-survivors than the survivors (p=0.036). However, the fT3 level was notthe independent factor for mortality rate in linear regression analysis (p=0.652). APACHE II and procalcitoninlevels as independent predictors of mortality (p=0.017). fT3 remained an independent factor for the lengthof ICU stay (p=0.024) and the length of hospital stay (p=0.031).Conclusion: fT3 is a prognostic indicator that can predict hospital and ICU length of stay in critically ill patientswith Covid-19. In the future, a broader panel of validated biochemical markers, including fT3 levels,may become a simple tool for stratified management of patients with severe COVID-19.

ABSTRACTObjective: Thyroid gland can be affected both by cytokine storm and through angiotensin-convertingenzyme 2 receptors. A worse prognosis has been described in patients with low fT3 levels. The aim ofthis study is to evaluate the prognostic significance of thyroid function during COVID-ICU hospitalization.Material and Methods: After ethical approval, 100 COVID-19 patients followed in the ICU between March2020 and April 2021 was admitted to study. Patients with previous thyroid disease were excluded fromstudy. Free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) levels at ICUadmission were evaluated. Clinical, demographic, laboratory, treatment, and outcome data were obtainedfrom the patient's electronic hospital records. Mann Whitney U, Spearman correlation, binary logistic, andlinear regression tests were used for statistical analysis.Results: TSH was in 31 patients, fT3 was in 37 patients, and fT4 was in 54 patients, which were outside thenormal ranges. fT3 were lower in non-survivors than the survivors (p=0.036). However, the fT3 level was notthe independent factor for mortality rate in linear regression analysis (p=0.652). APACHE II and procalcitoninlevels as independent predictors of mortality (p=0.017). fT3 remained an independent factor for the lengthof ICU stay (p=0.024) and the length of hospital stay (p=0.031).Conclusion: fT3 is a prognostic indicator that can predict hospital and ICU length of stay in critically ill patientswith Covid-19. In the future, a broader panel of validated biochemical markers, including fT3 levels,may become a simple tool for stratified management of patients with severe COVID-19.