hakansabunis/tr-academic-research-agent-index huggingface dataset:
Relationship of intima-media thickness with Gensini score that determines the severity of coronary artery disease
Relationship of intima-media thickness with Gensini score that determines the severity of coronary artery disease
Yazar: Alan, Bircan; Hattapoğlu, Salih; Dusak, Abdurrahim; Aktan, Adem
Dergi: Dicle Tıp Dergisi, Vol. 42 No. 4, 2016
Anahtar kelimeler: Karotis intima media kalınlığı, gensini skoru, koroner arter hastalığı, ultrasonografi

Objective: In this study we aimed to compare carotid intima-media thickness (CIMT) with Gensini score which objective evidence to demonstrate the severity of coronary artery disease.Methods: The study included 76 CAD patients (41 men, 35 women, mean age 60.7±11.2 years, range: 42-83) We calculated the Gensini score and measured CIMT for each patient, CAD patients was separated into two groups: patients with mild atherosclerosis (Gensini score <25 points) and severe atherosclerosis (Gensini score ≥25 points). The CIMT values were compared to Gensini score (CAD severity).Results: The severe atherosclerosis group had significantly higher CIMT values compared to the mild atherosclerosis group [(1.2±0.16 range: 0.90-1.50), (0.97±0.07 range: 0.90-1.10), p<0.01, respectively].There was a significant correlation with CIMT and Gensini score, age, BMI, LDL cholesterol [(r= 0.365, p<0.01), (r=0.327, p=0.03), (r=-0.341, p<0.01), (r=0.385, p<0.01), respectively.Conclusion: We found a significant association between CIMT and Gensini score which objective evidence to severity of CAD. As a non-invasive measurement CIMT can be used as an additional method in recognition of severe coronary artery diseaseKey words: Carotid intima-media thickness, Gensini score, coronary artery disease, ultrasonography

Objective: In this study we aimed to compare carotid intima-media thickness (CIMT) with Gensini score which objective evidence to demonstrate the severity of coronary artery disease.Methods: The study included 76 CAD patients (41 men, 35 women, mean age 60.7±11.2 years, range: 42-83) We calculated the Gensini score and measured CIMT for each patient, CAD patients was separated into two groups: patients with mild atherosclerosis (Gensini score <25 points) and severe atherosclerosis (Gensini score ≥25 points). The CIMT values were compared to Gensini score (CAD severity).Results: The severe atherosclerosis group had significantly higher CIMT values compared to the mild atherosclerosis group [(1.2±0.16 range: 0.90-1.50), (0.97±0.07 range: 0.90-1.10), p<0.01, respectively].There was a significant correlation with CIMT and Gensini score, age, BMI, LDL cholesterol [(r= 0.365, p<0.01), (r=0.327, p=0.03), (r=-0.341, p<0.01), (r=0.385, p<0.01), respectively.Conclusion: We found a significant association between CIMT and Gensini score which objective evidence to severity of CAD. As a non-invasive measurement CIMT can be used as an additional method in recognition of severe coronary artery diseaseKey words: Carotid intima-media thickness, Gensini score, coronary artery disease, ultrasonography
Our results of mini open approach in patients with carpal tunnel syndrome
Our results of mini open approach in patients with carpal tunnel syndrome
Yazar: Yıldırım, Azad; Kapukaya, Ahmet; Yiğit, Şehmus; Atiç, Ramazan; Mertsoy, Yılmaz; Çaçan, Mehmet
Dergi: Dicle Tıp Dergisi, Vol. 42 No. 4, 2016
Anahtar kelimeler: Karpal tünel, mini açık, pillar

Objective: In this study, we aimed to evaluate the results of patients underwent surgical release with mini open surgical method due to Carpal tunnel syndrome (CTS) and the surgical technique.Methods: 50 wrists of the 42 patients that we could reach after they were applied mini open surgical method between 2009- 2013 were analyzed retrospectively. After surgery, patients were followed for an average 47.4 months. CTS was detected in 26 of the patients in right hand, in 10 of the patients in left hand and in seven of them bilaterally. In 27 Preoperative patients advanced in 21 intermediate and in 2 mild Electromyography (EMG) findings compliant with CTS were found.Results: We did not apply a second operation to any of our patients. None of the patients showed any post operative sensitivity on scar tissue and there was no neurovascular damage in any patients during the surgery. The patients returned to their daily activities average on the 10th day after the surgery [range 7-15 days]. In their follow up EMG was not done on a routine basis to the patients. Patients were followed clinically.Conclusion: The advantages of the surgery process we conducted with over pillar mini incision compared to other techniques that there is less pillar region pain and less scar tenderness, shorter return to work and the technique is efficient, cheap and easy to apply.Key words: Carpal tunnel, mini open, pillar

Objective: In this study, we aimed to evaluate the results of patients underwent surgical release with mini open surgical method due to Carpal tunnel syndrome (CTS) and the surgical technique.Methods: 50 wrists of the 42 patients that we could reach after they were applied mini open surgical method between 2009- 2013 were analyzed retrospectively. After surgery, patients were followed for an average 47.4 months. CTS was detected in 26 of the patients in right hand, in 10 of the patients in left hand and in seven of them bilaterally. In 27 Preoperative patients advanced in 21 intermediate and in 2 mild Electromyography (EMG) findings compliant with CTS were found.Results: We did not apply a second operation to any of our patients. None of the patients showed any post operative sensitivity on scar tissue and there was no neurovascular damage in any patients during the surgery. The patients returned to their daily activities average on the 10th day after the surgery [range 7-15 days]. In their follow up EMG was not done on a routine basis to the patients. Patients were followed clinically.Conclusion: The advantages of the surgery process we conducted with over pillar mini incision compared to other techniques that there is less pillar region pain and less scar tenderness, shorter return to work and the technique is efficient, cheap and easy to apply.Key words: Carpal tunnel, mini open, pillar
Primer mesane yerleşimli koryokarsinom olgusu
Primer mesane yerleşimli koryokarsinom olgusu
Yazar: Türkcü, Gül; Keleş, Ayşe; Alabalık, Ulaş; Bozkurt, Yaşar; Büyükbayram, Hüseyin
Dergi: Dicle Tıp Dergisi, Vol. 42 No. 4, 2016
Anahtar kelimeler: koryokarsinom, mesane, sinsityotrofoblast

Koryokarsinom sıklıkla kadınlarda uterusta ve overlerde, erkeklerde testiste gelişim gösteren kötü prognozlu bir tümördür. Primer mesane yerleşimli koryokarsinom ise oldukça nadir olarak görülmektedir. Solunum güçlüğü, öksürük, hematüri ve disüri şikayetleri ile hastaneye başvuran 28 yaşındaki erkek olgunun yapı- lan radyolojik incelemelerinde akciğerlerde metastaz ile uyumlu lezyonlar ve mesane ön duvarında lümen içine uzanım gösteren kitle tespit edildi. Olguya yapılan sistoskopik inceleme esnasında tümör dokusuna inkomplet transüretral rezeksiyon uygulandı. Tümör dokusunun histopatolojik incelemesinde polihedral iri mononükleer hücreler arasında sinsityotrofoblast ile uyumlu hücreler izlendi. Tümör dokusunda pansitokeratin, sitokeratin 7, yüksek molekül ağırlıklı sitokeratin, human plasental laktojen ve human koryonik gonadotropin ile boyanma izlenirken, epitelyal membran antijen, karsinoembriyonik antijen, CD30, p63 ve sitokeratin 20 ile boyanma görülmedi. Mevcut histopatolojik ve immünohistokimyasal bulgular koryokarsinom ile uyumlu olarak değerlendirildi. Olgunun nadir görülmesi, kötü prognozlu olup genellikle metastaz ile ölüme sebep olabilmesi ve yüksek dereceli ürotelyal karsinomların ayırıcı tanısında akılda bulundurulması gerekliliği nedeni ile literatür bilgileri eşliğinde sunulması amaçlanmıştır.

Koryokarsinom sıklıkla kadınlarda uterusta ve overlerde, erkeklerde testiste gelişim gösteren kötü prognozlu bir tümördür. Primer mesane yerleşimli koryokarsinom ise oldukça nadir olarak görülmektedir. Solunum güçlüğü, öksürük, hematüri ve disüri şikayetleri ile hastaneye başvuran 28 yaşındaki erkek olgunun yapı- lan radyolojik incelemelerinde akciğerlerde metastaz ile uyumlu lezyonlar ve mesane ön duvarında lümen içine uzanım gösteren kitle tespit edildi. Olguya yapılan sistoskopik inceleme esnasında tümör dokusuna inkomplet transüretral rezeksiyon uygulandı. Tümör dokusunun histopatolojik incelemesinde polihedral iri mononükleer hücreler arasında sinsityotrofoblast ile uyumlu hücreler izlendi. Tümör dokusunda pansitokeratin, sitokeratin 7, yüksek molekül ağırlıklı sitokeratin, human plasental laktojen ve human koryonik gonadotropin ile boyanma izlenirken, epitelyal membran antijen, karsinoembriyonik antijen, CD30, p63 ve sitokeratin 20 ile boyanma görülmedi. Mevcut histopatolojik ve immünohistokimyasal bulgular koryokarsinom ile uyumlu olarak değerlendirildi. Olgunun nadir görülmesi, kötü prognozlu olup genellikle metastaz ile ölüme sebep olabilmesi ve yüksek dereceli ürotelyal karsinomların ayırıcı tanısında akılda bulundurulması gerekliliği nedeni ile literatür bilgileri eşliğinde sunulması amaçlanmıştır.
Peroxisomal disorder characterized with severe cerebral dysgenesis and hypotonia
Peroxisomal disorder characterized with severe cerebral dysgenesis and hypotonia
Yazar: Yeşilbaş, Osman; Kıhtır, Hasan; Ersoy, Melike; Yıldırım, Hamd; Sungur, Müge; Şevketoğlu, Esra
Dergi: Dicle Tıp Dergisi, Vol. 42 No. 4, 2016
Anahtar kelimeler: peroksizomal hastalık, hipotoni, ağır beyin disgenezisi

Very long chain fatty acids accumulate in many tissues and organs in the peroxisomal disorders due to defects in fatty acid metabolism. Although the disease may be manifested as severe symptoms causing early death due to hypotonia, poor feeding, respiratory problems, cerebral dysgenesis, liver and kidney dysfunctions, it may be presented as late onset with mild symptoms. We presented a 4 months-old male infant with peroxisomal disorder diagnosed by dysmorphic facial appearance, hypotonia since birth, feeding difficulties, respiratory distress, severe cerebral dysgenesis and increased very long chain fatty acids due to its rarity.Key words: Peroxisomal disorder, hypotonia, severe cerebral dysgenesis

Very long chain fatty acids accumulate in many tissues and organs in the peroxisomal disorders due to defects in fatty acid metabolism. Although the disease may be manifested as severe symptoms causing early death due to hypotonia, poor feeding, respiratory problems, cerebral dysgenesis, liver and kidney dysfunctions, it may be presented as late onset with mild symptoms. We presented a 4 months-old male infant with peroxisomal disorder diagnosed by dysmorphic facial appearance, hypotonia since birth, feeding difficulties, respiratory distress, severe cerebral dysgenesis and increased very long chain fatty acids due to its rarity.Key words: Peroxisomal disorder, hypotonia, severe cerebral dysgenesis
Anaesthetic management of a patient with hereditary angioedema
Anaesthetic management of a patient with hereditary angioedema
Yazar: Ataol, Nergis; Öksüz, Murat; Korkmaz, Feride; Öztürk, Alaattin
Dergi: Dicle Tıp Dergisi, Vol. 42 No. 4, 2016
Anahtar kelimeler: Herediter anjioödem, C1 esteraz inhibitörü, İnguinal herni

Hereditary angioedema is a rare autosomal dominant disorder caused by reduced activity of the C1 esterase inhibitor. Patients with hereditary angioedema are clinically characterized by recurrent episodes of swelling of the extremities, face, trunk, airways and abdominal organs. Attacks may occur either spontaneously or following trauma, stress, surgery, infections and hormonal fluctuations. The most common cause of death is asphyxia related to laryngeal edema. Giving C1 esterase inhibitor is the most effective method of treatment. Also fresh frozen plasma, androgen steroids, quinine pathway inhibitors, antifibrinolytics and bradykinin receptor antagonists can be used as treatment. In this paper, the anesthetic management of a patient with hereditary angioedema undergoing inguinal hernia repair surgery is reported.Key words: Hereditary angioedema; C1 esterase inhibitor; Inguinal hernia

Hereditary angioedema is a rare autosomal dominant disorder caused by reduced activity of the C1 esterase inhibitor. Patients with hereditary angioedema are clinically characterized by recurrent episodes of swelling of the extremities, face, trunk, airways and abdominal organs. Attacks may occur either spontaneously or following trauma, stress, surgery, infections and hormonal fluctuations. The most common cause of death is asphyxia related to laryngeal edema. Giving C1 esterase inhibitor is the most effective method of treatment. Also fresh frozen plasma, androgen steroids, quinine pathway inhibitors, antifibrinolytics and bradykinin receptor antagonists can be used as treatment. In this paper, the anesthetic management of a patient with hereditary angioedema undergoing inguinal hernia repair surgery is reported.Key words: Hereditary angioedema; C1 esterase inhibitor; Inguinal hernia
Molecular epidemiology of Blastocystis
Molecular epidemiology of Blastocystis
Yazar: Eroğlu, Fadime
Dergi: Dicle Tıp Dergisi, Vol. 42 No. 4, 2016
Anahtar kelimeler: Blastocystis, alt tip, patojenite

Blastocystis pathogenicity and classification was newly illuminated with molecular genetic studies and recently the parasite was found in the focus of many researchers. Several molecular methods such as; polymerase chain reaction (PCR), PCR-restriction fragment length polymorphism, random amplified polymorphic DNA, real-time polymerase chain reaction and DNA sequencing analyses can be used in genotyping of Blastocystis. Blastocystis parasites may cause diarrhea, abdominal pain, bloating, gas, irritability, anorexia, cramps, vomiting, dehydration, insomnia, nausea, loss of appetite, weight loss, fatigue symptoms and also could be asymptomatic cases. In this review, it was aimed to summarize the associations between Blastocystis subtypes and pathogenicity.Key words: Blastocystis, subtype, pathogenicity

Blastocystis pathogenicity and classification was newly illuminated with molecular genetic studies and recently the parasite was found in the focus of many researchers. Several molecular methods such as; polymerase chain reaction (PCR), PCR-restriction fragment length polymorphism, random amplified polymorphic DNA, real-time polymerase chain reaction and DNA sequencing analyses can be used in genotyping of Blastocystis. Blastocystis parasites may cause diarrhea, abdominal pain, bloating, gas, irritability, anorexia, cramps, vomiting, dehydration, insomnia, nausea, loss of appetite, weight loss, fatigue symptoms and also could be asymptomatic cases. In this review, it was aimed to summarize the associations between Blastocystis subtypes and pathogenicity.Key words: Blastocystis, subtype, pathogenicity
Ceza İnfaz Kurumlarının Yönetim, Dış Koruma, Hükümlü ve Tutukluların Sevk ve Nakilleri ile Sağlık Hizmetlerinin Yürütülmesi Hakkındaki Protokolün Bir Olgu Sunumu Üzerinden Adli Tıbbi Değerlendirilmesi
Forensic Medical Assessment of the Protocol on the Management of Prisons and Detention Houses, External Protection, Dispatch and Transport and Implementation of Health Services of the Convicts and Prisons from a Case Report
Yazar: Tıraşçı, Yaşar; Uysal, Cem; Altınal, Aydın; Akın, Mustafa; Durmaz, Ubeydullah
Dergi: Dicle Tıp Dergisi, Vol. 44 No. 4, 2017
Anahtar kelimeler: Health Care Administration ; Sağlık Kurumları Yönetimi ; Istanbul Protocol,Triple Protocol,Prisoner/Convict Examination ; İstanbul Protokolü,3’lü Protokol,Tutuklu/Hükümlü Muayenesi

Hekimlik mesleğinin; hastalar arasında sosyal durum, dini inanç, siyasi görüş, milliyet, cinsiyet, yaş ve sosyoekonomik durum farklılıkları gözetmeksizin icra edilmesi gerekmektedir. Ancak tutuklu/hükümlü muayenelerinde Ceza İnfaz Kurumlarının Yönetim, Dış Koruma, Hükümlü ve Tutukluların Sevk ve Nakilleri ile Sağlık Hizmetlerinin Yürütülmesi Hakkındaki Protokolün (3’lü Protokol) yorumlanması ve uygulanmasına bağlı olarak çeşitli sorunlarla karşılaşılmaktadır. Bu çalışmamızda kolluk kuvvetleri eşliğinde cezaevinden Dicle Üniversitesi Tıp Fakültesi Adli Tıp AD’na muayeneye getirilen bir şahsın muayenesi esnasında kolluk kuvvetleri ile hekimler arasında 3’lü protokol nedeniyle yaşanan bir olay ele alınmış olup çözüm önerilerinde bulunulmuştur.

In medical profession, depending on its own ethical rules, does not discriminate patients among social status, religious beliefs, political views, nationality, sex, age, social position and economic situation. But there are many contradictions depending on the interpretation and application of The Protocol on the Management of Prisons and Detention Houses, External Protection, Dispatch and Transport and Implementation of Health Services of the Convicts and Prisons (triple protocol). In this study, we discuss an unpleasant case due to implication of the triple protocol between the law enforcement officers and the physicians during the examination of a person brought to Dicle University Medical Faculty Department of Forensic Medicine from jail and we make suggestions to overcome the some troubles.
Investigation of serum oxidative stress levels in  patients with nasal polyps
Investigation of serum oxidative stress levels in  patients with nasal polyps
Yazar: Ekinci, Adnan
Dergi: Dicle Tıp Dergisi, Vol. 45 No. 1, 2018
Anahtar kelimeler: Health Care Administration ; Sağlık Kurumları Yönetimi ; Nasal Polyp,Total Oxidant Status,Total Antioxidant Status

Objective:  To  compare  serum  total  antioxidant  status  (TAS),  total  oxidant  status  (TOS),  and  paraoxonase  (PON1) levels between nasal polyp patients and heal thy subjects.Method: In the present study, The nasal polyp group includes 26 males an 22 females, a total of 48 patients (mean age 37.11±12.07 years), while the control group included 22 males and 24 females, a total of 46 healthy subjects (mean age 36.91±13.03) years. Groups were compared in terms of serum TAS, TOS and PON1 levels. Results:  The  mean  TAS  level  was  1.248  mmol/L  in  the  control  group,  it  was  1.176  mmol/L  in  the  patient  group (p=0.044). The mean TOS level was 3.443 mmol/L in the control group, and it was 6.720 mmol/L in the patient group (p=006).  Nasal  polyp  and  control  groups  did  not  show  any  significant  difference  for  PON1  (301.15  U/L  vs.  295.75 U/L,p>0.05).  Conclusion: Serum TOS levels were significantly higher, and TAS levels were significantly lower in patients with nasal polyposis  compared  it  the  control  group.  There  was  no  significant  difference  between  the  patients  with  nasal polypand the control group in terms of the PON1 values.

Objective:  To  compare  serum  total  antioxidant  status  (TAS),  total  oxidant  status  (TOS),  and  paraoxonase  (PON1) levels between nasal polyp patients and heal thy subjects.Method: In the present study, The nasal polyp group includes 26 males an 22 females, a total of 48 patients (mean age 37.11±12.07 years), while the control group included 22 males and 24 females, a total of 46 healthy subjects (mean age 36.91±13.03) years. Groups were compared in terms of serum TAS, TOS and PON1 levels. Results:  The  mean  TAS  level  was  1.248  mmol/L  in  the  control  group,  it  was  1.176  mmol/L  in  the  patient  group (p=0.044). The mean TOS level was 3.443 mmol/L in the control group, and it was 6.720 mmol/L in the patient group (p=006).  Nasal  polyp  and  control  groups  did  not  show  any  significant  difference  for  PON1  (301.15  U/L  vs.  295.75 U/L,p>0.05).  Conclusion: Serum TOS levels were significantly higher, and TAS levels were significantly lower in patients with nasal polyposis  compared  it  the  control  group.  There  was  no  significant  difference  between  the  patients  with  nasal polypand the control group in terms of the PON1 values.
Lepralı hastaların yaşam kalitesinin değerlendirilmesi
Lepralı hastaların yaşam kalitesinin değerlendirilmesi
Yazar: Baysal, Hasret Yalçınöz; Bilgin, Sonay; Kaşıkçı, Çağla Köktürk
Dergi: Dicle Tıp Dergisi, Vol. 45 No. 1, 2018
Anahtar kelimeler: Health Care Administration ; Sağlık Kurumları Yönetimi ; Lepra,hemşirelik

Giriş: Bu çalışma İzmir’de, lepralı hastaların yaşamkalitelerinin ve buna etki eden sosyo-demografik özelliklerin belirlenmesiamacıyla yapılmıştır.Yöntemler: Tanımlayıcı olarak yapılan araştırma Ocak 2013ile Ocak 2014 tarihleri arasında İzmir ili Deri ve Tenasül HastalıklarıDispanserine kayıtlı olan 59 lepralı hasta ile yürütülmüştür. Veriler soruformu ve SF-36 yaşam kalitesi ölçeği ile toplanmış, SPSS 21.0 paket programaracılığı ile analiz edilmiştir. Verilerin değerlendirilmesinde yüzde,ortalama, Mann-Whitney U testi ve Kruskall Wallis testi yapılmıştır. Bulgular: Araştırmaya katılan lepra hastalarının SF-36fiziksel işlevsellik puan ortalaması (23.4±6.9) yüksek, emosyonel rol güçlüğü(1.4±1.4) puanlarının ise düşük olduğu belirlenmiştir. Yaş, medeni durum, hasardurumu, hasar bölgesi ve eğitim durumu gibi özelliklerin Lepralı hastalarınyaşam kalitesini etkilediği belirlenmiştir.Sonuç: Bu çalışma Lepralı hastaların emosyonel yöndendesteğe ihtiyaçları olduğunu ortaya koymuştur. Lepra hastalarının yaşamkalitesini artırmak için hemşirelerin bu hastaları emosyonel yöndendesteklemeleri önerilebilir.

Giriş: Bu çalışma İzmir’de, lepralı hastaların yaşamkalitelerinin ve buna etki eden sosyo-demografik özelliklerin belirlenmesiamacıyla yapılmıştır.Yöntemler: Tanımlayıcı olarak yapılan araştırma Ocak 2013ile Ocak 2014 tarihleri arasında İzmir ili Deri ve Tenasül HastalıklarıDispanserine kayıtlı olan 59 lepralı hasta ile yürütülmüştür. Veriler soruformu ve SF-36 yaşam kalitesi ölçeği ile toplanmış, SPSS 21.0 paket programaracılığı ile analiz edilmiştir. Verilerin değerlendirilmesinde yüzde,ortalama, Mann-Whitney U testi ve Kruskall Wallis testi yapılmıştır. Bulgular: Araştırmaya katılan lepra hastalarının SF-36fiziksel işlevsellik puan ortalaması (23.4±6.9) yüksek, emosyonel rol güçlüğü(1.4±1.4) puanlarının ise düşük olduğu belirlenmiştir. Yaş, medeni durum, hasardurumu, hasar bölgesi ve eğitim durumu gibi özelliklerin Lepralı hastalarınyaşam kalitesini etkilediği belirlenmiştir.Sonuç: Bu çalışma Lepralı hastaların emosyonel yöndendesteğe ihtiyaçları olduğunu ortaya koymuştur. Lepra hastalarının yaşamkalitesini artırmak için hemşirelerin bu hastaları emosyonel yöndendesteklemeleri önerilebilir.