İnflamatuvar barsak hastalıkları aktivitesi ile serum neopterin  düzeyi arasındaki ilişki
Relationship between serum neopterin levels and inflammatory bowel diseases activity
Yazar: Ertuğrul, İbrahim; Yolcu, Ömer Faruk; Cesur, Salih; Dağlı, Ülkü; Başar, Ömer; Yüksel, İlhami; Çakal, Başak; Özin, Yasemin Ö.; İbiş, Mehmet; Ataseven, Hilmi; Tunç, Bilge; Ülker, Aysel; Şaşmaz, Nurgül
Dergi: Akademik Gastroenteroloji Dergisi, Vol. 6 No. 2, 2015
Anahtar kelimeler: Neopterin, inflammatory bowel diseases, Crohn's disease,  ulcerative colitis ; Neopterin, inflamatuvar barsak hastalığı, crohn  hastalığı, ülseratif kolit

Background/aims: The etiology of inflammatory bowel diseases,  chronic intestinal diseases characterized by remissions and activation  periods, is still unknown. Identification of the active period is important  because it guides the therapy and point outs the prognosis.  To date, there is still a lack of agreement on determining the active  state. Neopterin is produced in monocytes/macrophages primarily  upon stimulation with interferon-gamma. It is a marker associated  with cell-mediated immunity. The aim of this study was to investigate  the role of serum neopterin levels in Crohn's disease and ulcerative  colitis disease activity. Materials and methods: Sixty-one  patients with ulcerative colitis (21 female, 40 male) and 27 patients  with Crohn's disease (9 female, 18 male) who were followed up at  Türkiye Yüksek İhtisas Hospital were enrolled into the study. Fiftytwo  healthy controls (22 female, 30 male) were also enrolled. Neopterin  is measured by enzyme-linked immunosorbent assay. Serum  levels >10 nmol/L are regarded as elevated. Patients with malignancy  and systemic infectious diseases were not included in the  study. For statistical analysis, one-way ANOVA, Pearson correlation  analysis test, Fisher's exact test, Mann-Whitney U test and Student's  test were used. Significance was established at p

Background/aims: The etiology of inflammatory bowel diseases,  chronic intestinal diseases characterized by remissions and activation  periods, is still unknown. Identification of the active period is important  because it guides the therapy and point outs the prognosis.  To date, there is still a lack of agreement on determining the active  state. Neopterin is produced in monocytes/macrophages primarily  upon stimulation with interferon-gamma. It is a marker associated  with cell-mediated immunity. The aim of this study was to investigate  the role of serum neopterin levels in Crohn's disease and ulcerative  colitis disease activity. Materials and methods: Sixty-one  patients with ulcerative colitis (21 female, 40 male) and 27 patients  with Crohn's disease (9 female, 18 male) who were followed up at  Türkiye Yüksek İhtisas Hospital were enrolled into the study. Fiftytwo  healthy controls (22 female, 30 male) were also enrolled. Neopterin  is measured by enzyme-linked immunosorbent assay. Serum  levels >10 nmol/L are regarded as elevated. Patients with malignancy  and systemic infectious diseases were not included in the  study. For statistical analysis, one-way ANOVA, Pearson correlation  analysis test, Fisher's exact test, Mann-Whitney U test and Student's  test were used. Significance was established at p