MANAGEMENT OF PATIENTS WITH THYROIDASSOCIATED OPHTHALMOPATHY: ROLE OF SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY Tiroid İlişkili Oftalmopatili Hastaların Yönetimi: Spektral Alan Optik Koherens Tomografinin Rolü
MANAGEMENT OF PATIENTS WITH THYROIDASSOCIATED OPHTHALMOPATHY: ROLE OF SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY Tiroid İlişkili Oftalmopatili Hastaların Yönetimi: Spektral Alan Optik Koherens Tomografinin Rolü
Yazar: Dagdelen, Kenan; Muz, Ömer Ersin
Dergi: Bozok Tıp Dergisi, Vol. 12 No. 3, 2022
Anahtar kelimeler: Health Care Administration ; Sağlık Kurumları Yönetimi ; MANAGEMENT OF PATIENTS WITH THYROIDASSOCIATED,OPHTHALMOPATHY: ROLE OF SPECTRALDOMAIN OPTICAL COHERENCE TOMOGRAPHY,Tiroid İlişkili Oftalmopatili Hastaların Yönetimi: Spektral AlanOptik Koherens Tomografinin Rolü

ABSTRACTObjective: To demonstrate the changes in optic nerve head (ONH), retinal nerve fiber layer (RNFL) andmacula in patients with thyroid-associated ophthalmopathy (TAO) by spectral domain optical coherencetomography (SD-OCT).Material and Methods: We included forty-one eyes of 41 patients with a diagnosis of TAO and forty-eighteyes of 48 age- and sex-matched healthy subjects (control group) from June 2016 to July 2018. The ONHparameters, RNFL and macular thicknesses in the nine macular quadrants were measured with SD-OCT.Proptosis level was determined by Hertel exophthalmometer. Clinical activity score (CAS) according to theEuropean Group of Graves' Orbitopathy (EUGOGO) guidelines was determined in all patients. Student t-testwas used to compare study and control groups. A p value less than 0.05 was considered as statisticallysignificant.Results: Superior, inferior, and average RNFL thicknesses were significantly lower in the TAO group comparedto the control group (p < 0.05). Optic disc area was significantly larger in the TAO group. Outer quadrantmacular thicknesses and average macular thicknesses were significantly lower in the TAO group (p < 0.05).CAS had a weak correlation with RNFL thickness and average macular thickness.Conclusion: Alterations in RNFL thicknesses and macular thicknesses can be detected before the developmentof ocular symptoms in patients with TAO. Patients can be diagnosed at an early stage prior to thedevelopment of functional damage. However, the low number of studies investigating this subject and theconflicting findings of existing studies necessitate further studies.

ABSTRACTObjective: To demonstrate the changes in optic nerve head (ONH), retinal nerve fiber layer (RNFL) andmacula in patients with thyroid-associated ophthalmopathy (TAO) by spectral domain optical coherencetomography (SD-OCT).Material and Methods: We included forty-one eyes of 41 patients with a diagnosis of TAO and forty-eighteyes of 48 age- and sex-matched healthy subjects (control group) from June 2016 to July 2018. The ONHparameters, RNFL and macular thicknesses in the nine macular quadrants were measured with SD-OCT.Proptosis level was determined by Hertel exophthalmometer. Clinical activity score (CAS) according to theEuropean Group of Graves' Orbitopathy (EUGOGO) guidelines was determined in all patients. Student t-testwas used to compare study and control groups. A p value less than 0.05 was considered as statisticallysignificant.Results: Superior, inferior, and average RNFL thicknesses were significantly lower in the TAO group comparedto the control group (p < 0.05). Optic disc area was significantly larger in the TAO group. Outer quadrantmacular thicknesses and average macular thicknesses were significantly lower in the TAO group (p < 0.05).CAS had a weak correlation with RNFL thickness and average macular thickness.Conclusion: Alterations in RNFL thicknesses and macular thicknesses can be detected before the developmentof ocular symptoms in patients with TAO. Patients can be diagnosed at an early stage prior to thedevelopment of functional damage. However, the low number of studies investigating this subject and theconflicting findings of existing studies necessitate further studies.