ANALYSIS OF NEW POTENTIAL HEMOGRAM BIOMARKERS IN PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH EPILEPTIC SEIZURES Acil Servise Epileptik Nöbet ile Başvuran Hastalarda Yeni Potansiyel Hemogram Biyobelirteçlerinin Analizi
ANALYSIS OF NEW POTENTIAL HEMOGRAM BIOMARKERS IN PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH EPILEPTIC SEIZURES Acil Servise Epileptik Nöbet ile Başvuran Hastalarda Yeni Potansiyel Hemogram Biyobelirteçlerinin Analizi
Yazar: Çaltekin, İbrahim; Aygün, Ali; Tomakin, Mesut; Yazıcı, Ramiz; Albayrak, Güneş Seda
Dergi: Bozok Tıp Dergisi, Vol. 14 No. 3, 2024
Anahtar kelimeler: Emergency Medicine ; Acil Tıp ; ANALYSIS OF NEW POTENTIAL HEMOGRAMBIOMARKERS IN PATIENTS PRESENTING TO THE,EMERGENCY DEPARTMENT WITH EPILEPTIC SEIZURES,Acil Servise Epileptik Nöbet ile Başvuran Hastalarda YeniPotansiyel Hemogram Biyobelirteçlerinin Analizi

ABSTRACTObjective: We aimed to analyze the diagnostic value of new potential hemogram biomarkers in patientspresenting to the emergency department with epileptic seizures.Material and Methods: Patients presenting with epileptic seizures to a tertiary hospital's emergency departmentbetween January 1, 2023, and January 1, 2024, were retrospectively reviewed. The patients werecategorized into Group A (seizure patients) and Group B (healthy volunteers). Hemogram and biochemistrydata from routine blood tests were examined. To predict seizure status, ROC analysis was performed toevaluate NLR, PLR and PNR. The area under the curve and cutoff values were calculated for each marker.Results: Our study examined two groups: seizure patients and the control group. The mean age of the seizuregroup was 50.31±1.83 years, and the mean age of the control group was 49.58±1.96 years (p>0.05). Inthe seizure group (n=116), 55.8% were male and 44.2% were female, whereas in the control group (n=104),57.8% were male and 42.2% were female (p>0.05). WBC, neutrophil count, NLR, and PLR values were significantlyhigher in seizure patients compared to the control group (p<0.001, p<0.001, p<0.001, and p=0.035,respectively). PNR and lymphocyte values were significantly lower in seizure patients compared to the controlgroup (p<0.001 and p=0.01, respectively).Conclusion: We found significant changes in NLR, PLR, and PNR values in patients with epileptic seizures.We believe that these biomarkers can assist clinicians in diagnosing seizures and distinguishing betweenseizures and pseudoseizures, especially in emergency departments.

ABSTRACTObjective: We aimed to analyze the diagnostic value of new potential hemogram biomarkers in patientspresenting to the emergency department with epileptic seizures.Material and Methods: Patients presenting with epileptic seizures to a tertiary hospital's emergency departmentbetween January 1, 2023, and January 1, 2024, were retrospectively reviewed. The patients werecategorized into Group A (seizure patients) and Group B (healthy volunteers). Hemogram and biochemistrydata from routine blood tests were examined. To predict seizure status, ROC analysis was performed toevaluate NLR, PLR and PNR. The area under the curve and cutoff values were calculated for each marker.Results: Our study examined two groups: seizure patients and the control group. The mean age of the seizuregroup was 50.31±1.83 years, and the mean age of the control group was 49.58±1.96 years (p>0.05). Inthe seizure group (n=116), 55.8% were male and 44.2% were female, whereas in the control group (n=104),57.8% were male and 42.2% were female (p>0.05). WBC, neutrophil count, NLR, and PLR values were significantlyhigher in seizure patients compared to the control group (p<0.001, p<0.001, p<0.001, and p=0.035,respectively). PNR and lymphocyte values were significantly lower in seizure patients compared to the controlgroup (p<0.001 and p=0.01, respectively).Conclusion: We found significant changes in NLR, PLR, and PNR values in patients with epileptic seizures.We believe that these biomarkers can assist clinicians in diagnosing seizures and distinguishing betweenseizures and pseudoseizures, especially in emergency departments.