Long-term Outcomes of Surgical Management of Insulinoma: Single Center Experience
Long-term Outcomes of Surgical Management of Insulinoma: Single Center Experience
Yazar: Ulku, Abdullah; Yalav, Orcun; Saritas, A. Gokhan; Rencuzogullari, Ahmet; Dalci, Kubilay; Eray, İsmail Cem; Yagmur, Ozgur; Akcam, Atılgan Tolga
Dergi: Dicle Tıp Dergisi, Vol. 45 No. 2, 2018
Anahtar kelimeler: Health Care Administration ; Sağlık Kurumları Yönetimi ; insulinoma; surgical treatment; enucleation; pancreatic endocrine tumor.

Objective:Limited data are available in regards to the surgical management and outcomesof insulinoma. This study aimed to assess the outcomes associated with surgicaltreatment of insulinoma, as the most common pancreatic endocrine tumor. Methods:Medical records of patients who diagnosed as insulinoma from 2000 to 2010 atGeneral Surgery Department of Cukurova University Hospital were retrospectivelyreviewed. Surgical treatment (resection vs. enucleation) was based onpreoperative radiological investigations (abdominal spiral contrast tomography,ultrasound, selective angiography for selected cases) and intra-operativeultrasound imaging once indicated.Results:Surgically treated thirteen patients (F/M:9/4) who diagnosed with insulinomawere assessed with a mean follow-up of 5.3 (0.5-10) years. Enucleation anddistal pancreatectomy were performed for 11 and 2 (one of those isspleen-preserving) patients, respectively. No mortality was recorded. Allpatients became normoglycemic after surgery without re-operation and withacceptable complication rates (n=3 pancreatic fistula, n=1 pancreatitis). Conclusion:Surgical treatment of insulinoma is associated with favorable outcomes. Intra-operativeultrasound with manual palpation is still the gold standard for localizinginsulinoma. Location, size and relationship with main pancreatic duct of thelesions are key components for the selection of optimal surgical procedure.

Objective:Limited data are available in regards to the surgical management and outcomesof insulinoma. This study aimed to assess the outcomes associated with surgicaltreatment of insulinoma, as the most common pancreatic endocrine tumor. Methods:Medical records of patients who diagnosed as insulinoma from 2000 to 2010 atGeneral Surgery Department of Cukurova University Hospital were retrospectivelyreviewed. Surgical treatment (resection vs. enucleation) was based onpreoperative radiological investigations (abdominal spiral contrast tomography,ultrasound, selective angiography for selected cases) and intra-operativeultrasound imaging once indicated.Results:Surgically treated thirteen patients (F/M:9/4) who diagnosed with insulinomawere assessed with a mean follow-up of 5.3 (0.5-10) years. Enucleation anddistal pancreatectomy were performed for 11 and 2 (one of those isspleen-preserving) patients, respectively. No mortality was recorded. Allpatients became normoglycemic after surgery without re-operation and withacceptable complication rates (n=3 pancreatic fistula, n=1 pancreatitis). Conclusion:Surgical treatment of insulinoma is associated with favorable outcomes. Intra-operativeultrasound with manual palpation is still the gold standard for localizinginsulinoma. Location, size and relationship with main pancreatic duct of thelesions are key components for the selection of optimal surgical procedure.