OBSTRUKTİF UYKU APNE SENDROMU’NDA NÖTROFİL LENFOSİT ORANI Neutrophil To Lymphocyte Ratio In Obstructive Sleep Apnea Syndrome
OBSTRUKTİF UYKU APNE SENDROMU’NDA NÖTROFİL LENFOSİT ORANI Neutrophil To Lymphocyte Ratio In Obstructive Sleep Apnea Syndrome
Yazar: Erçen Diken, Özlem; Arslan, Mesut
Dergi: Bozok Tıp Dergisi, Vol. 8 No. 4, 2018
Anahtar kelimeler: OBSTRUKTİF UYKU APNE SENDROMU’NDA NÖTROFİL LENFOSİT ORANI Neutrophil To Lymphocyte Ratio In Obstructive Sleep Apnea Syndrome

ÖZETAmaç: Nötrofil ve lenfosit oranı (NLO)’nın inflamatuar belirteç olarak inflamatuar hastalıklarda rolü keşfedilmiştir.Obstruktif uyku apne sendromu (OSAS)’da komorbiditeler ile OSAS’da artan NLO arasındaki ilişkideğerlendirildi.Yöntem: Toplam 232 OSAS hastası çalışmaya alındı. 50 OSAS olmayan olgu kontrol grubunu oluşturdu. NLOher hasta ve kontrol olgusu için hesaplandı ve kaydedildi. Nötrofil lenfosit oranıyla hipertansiyon arasındakiilişki hipertansiyonu olan ve olmayan iki alt hasta grubunda değerlendirildi.Bulgular: Çalışmada 100 kadın (%43.1), 132 erkek (%56.9) hasta mevcuttu. OSAS hastalarında ortalama NLO(1.76±0.77), kontrol grubunda ortalama NLO (1.31±0.74) ile karşılaştırıldığında anlamlı olarak daha yüksekti(p= 0.000). Hipertansiyon (HT) olan (3.59±14.92) ve olmayan (1.72±0.69) OSAS’lı hastalarda NLO’da anlamlıfarklılık saptandı (p= 0.014).Sonuç: OSAS’da NLO inflamatuar belirteç olarak değerli olabilir. OSAS’da artan NLO, bu hastalardaki HT gibikomorbid durumlardan kaynaklanabilir. Bu ucuz ve pratik method, günlük klinik pratikte, OSAS hastalarındakomorbiditeyi öngörmek için kullanılabilir.Anahtar Sözcu¨kler: İnflamasyon; Nötrofil ve lenfosit orani; Obstruktif uyku apne sendromuABSTRACTObjective: The role of neutrophil to lymphocyte ratio as an inflammatory marker in inflammatory conditionshas been explored. The association between neutrophil to lymphocyte ratio, which is elevated in patientswith obstructive sleep apnea syndrome, and hypertension in obstructive sleep apnea syndrome has beenexamined.Methods: A total of 232 obstructive sleep apnea syndrome patients were included in this study. A totalof 50 subjects without obstructive sleep apnea syndrome comprised the control group. The neutrophilto lymphocyte ratio was calculated and recorded for each patient and control subject. The association ofneutrophil to lymphocyte ratio to hypertension was investigated in two sub-groups of patients defined onthe basis of the presence or absence of hypertension.Results: There were 100 (43.1%) female and 132 (56.9%) male patients in the study. Obstructive sleepapnea syndrome patients had significantly higher average neutrophil to lymphocyte ratio (1.76 ± 0.77)as compared to controls (1.31 ± 0.74) (p=0.000). A significant difference in neutrophil to lymphocyteratio between obstructive sleep apnea syndrome patients with (3.59 ± 14.92) or without (1.72 ± 0.69)hypertension was found (p=0.014).Conclusion: Neutrophil to lymphocyte ratio may find some value as an inflammatory marker in obstructivesleep apnea syndrome. Elevated neutrophil to lymphocyte ratio in obstructive sleep apnea syndrome mayarise from comorbid conditions such as hypertension in these patients. This cheap and practical methodmay be used in daily clinical practice to predict comorbidity in OSAS patients.Keywords: Inflammation; Neutrophil to lymphocyte ratio; OSAS; Obstructive sleep apnea syndrome; Sleepapnea

ÖZETAmaç: Nötrofil ve lenfosit oranı (NLO)’nın inflamatuar belirteç olarak inflamatuar hastalıklarda rolü keşfedilmiştir.Obstruktif uyku apne sendromu (OSAS)’da komorbiditeler ile OSAS’da artan NLO arasındaki ilişkideğerlendirildi.Yöntem: Toplam 232 OSAS hastası çalışmaya alındı. 50 OSAS olmayan olgu kontrol grubunu oluşturdu. NLOher hasta ve kontrol olgusu için hesaplandı ve kaydedildi. Nötrofil lenfosit oranıyla hipertansiyon arasındakiilişki hipertansiyonu olan ve olmayan iki alt hasta grubunda değerlendirildi.Bulgular: Çalışmada 100 kadın (%43.1), 132 erkek (%56.9) hasta mevcuttu. OSAS hastalarında ortalama NLO(1.76±0.77), kontrol grubunda ortalama NLO (1.31±0.74) ile karşılaştırıldığında anlamlı olarak daha yüksekti(p= 0.000). Hipertansiyon (HT) olan (3.59±14.92) ve olmayan (1.72±0.69) OSAS’lı hastalarda NLO’da anlamlıfarklılık saptandı (p= 0.014).Sonuç: OSAS’da NLO inflamatuar belirteç olarak değerli olabilir. OSAS’da artan NLO, bu hastalardaki HT gibikomorbid durumlardan kaynaklanabilir. Bu ucuz ve pratik method, günlük klinik pratikte, OSAS hastalarındakomorbiditeyi öngörmek için kullanılabilir.Anahtar Sözcu¨kler: İnflamasyon; Nötrofil ve lenfosit orani; Obstruktif uyku apne sendromuABSTRACTObjective: The role of neutrophil to lymphocyte ratio as an inflammatory marker in inflammatory conditionshas been explored. The association between neutrophil to lymphocyte ratio, which is elevated in patientswith obstructive sleep apnea syndrome, and hypertension in obstructive sleep apnea syndrome has beenexamined.Methods: A total of 232 obstructive sleep apnea syndrome patients were included in this study. A totalof 50 subjects without obstructive sleep apnea syndrome comprised the control group. The neutrophilto lymphocyte ratio was calculated and recorded for each patient and control subject. The association ofneutrophil to lymphocyte ratio to hypertension was investigated in two sub-groups of patients defined onthe basis of the presence or absence of hypertension.Results: There were 100 (43.1%) female and 132 (56.9%) male patients in the study. Obstructive sleepapnea syndrome patients had significantly higher average neutrophil to lymphocyte ratio (1.76 ± 0.77)as compared to controls (1.31 ± 0.74) (p=0.000). A significant difference in neutrophil to lymphocyteratio between obstructive sleep apnea syndrome patients with (3.59 ± 14.92) or without (1.72 ± 0.69)hypertension was found (p=0.014).Conclusion: Neutrophil to lymphocyte ratio may find some value as an inflammatory marker in obstructivesleep apnea syndrome. Elevated neutrophil to lymphocyte ratio in obstructive sleep apnea syndrome mayarise from comorbid conditions such as hypertension in these patients. This cheap and practical methodmay be used in daily clinical practice to predict comorbidity in OSAS patients.Keywords: Inflammation; Neutrophil to lymphocyte ratio; OSAS; Obstructive sleep apnea syndrome; Sleepapnea