Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control
Components of the Complete Blood Count in Type 2 Diabetes Mellitus with Inadequate Glycemic Control
Yazar: Kizilgul, Muhammed; Sencar, Erkam; Ucan, Bekir; Beysel, Selvihan; Ozcelik, Ozgur; Ozbek, Mustafa; Cakal, Erman
Dergi: Dicle Tıp Dergisi, Vol. 45 No. 2, 2018
Anahtar kelimeler: Health Care Administration ; Sağlık Kurumları Yönetimi ; Type 2 diabetes mellitus,complete blood count indices

Objective:Inadequate control of glycemia in diabetic patients is the primary cause ofboth micro- and macrovascular complications. Several components of completeblood count were investigated and have found to be higher in diabetic patients.We aimed to evaluate white blood cell (WBC), neutrophil, lymphocyte andplatelet counts and, red cell distribution width (RDW), mean platelet volume(MPV) and platelet distribution width (PDW) in type 2 diabetes mellitus (T2DM)patients with inappropriorate glycemic management (HbAlc >7%) despite using insulintherapy.Methods: 135type 2 diabetic patients with inappropriorate blood glucose management (HbAlcvalue >7 %) despite using insulin therapy for at least 3-month period (onlyinsulin or insulin plus oral hypoglycemic agents) and 121 healthy subjects wereincluded in the study. Demographic, anthropometric and laboratory data wererecorded.Results:WBC, neutrophil, lymphocyte and monocyte counts were higher in DM group(p<0.0001). WBC counts were positively correlated with diastolic bloodpressure (DBP), body mass index (BMI), waist circumference (WC) andhigh-sensitive C- reactive protein (hsCRP), fasting plasma glucose (FPG), post-prandialglucose (PPG), HbA1c and triglyceride levels (p<0.05). Neutrophil countswere positively correlated with hsCRP, FPG, HbA1c, BMI, PPG, LDL-Cholesterol(LDL-C) and microalbumin levels (p<0.05). Lymphocyte counts were positivelycorrelated with systolic blood pressure (SBP), DBP, BMI, WC and FPG, HbA1c,LDL-C and triglyceride levels (p<0.05). WBC, neutrophil and lymphocytecounts were negatively correlated with HDL-Cholesterol (HDL-C) levels(p<0.05). PDW was higher in DM group (16.65±0.59 to 16.51±0.51, p:0.043).PDW was positively correlated with age, DBP, FPG, PPG, HbA1c, LDL-C andtriglyceride levels (p<0.05). Monocyte to HDL-C ratio was higher in DM group(13.50 ± 5.34 to 10.54 ± 4.29, p<0.0001).Conclusions:In this study white blood cell, neutrophil and lymphocyte counts and PDW were higherin type 2 diabetic patients with inappropriorate glycemic management despiteinsulin therapy and they were correlated wıth cardio-metabolic risk factors. Leukocytesubtypes and PDW may be used as a marker for cardiovascular diseases in thesepatients.

Objective:Inadequate control of glycemia in diabetic patients is the primary cause ofboth micro- and macrovascular complications. Several components of completeblood count were investigated and have found to be higher in diabetic patients.We aimed to evaluate white blood cell (WBC), neutrophil, lymphocyte andplatelet counts and, red cell distribution width (RDW), mean platelet volume(MPV) and platelet distribution width (PDW) in type 2 diabetes mellitus (T2DM)patients with inappropriorate glycemic management (HbAlc >7%) despite using insulintherapy.Methods: 135type 2 diabetic patients with inappropriorate blood glucose management (HbAlcvalue >7 %) despite using insulin therapy for at least 3-month period (onlyinsulin or insulin plus oral hypoglycemic agents) and 121 healthy subjects wereincluded in the study. Demographic, anthropometric and laboratory data wererecorded.Results:WBC, neutrophil, lymphocyte and monocyte counts were higher in DM group(p<0.0001). WBC counts were positively correlated with diastolic bloodpressure (DBP), body mass index (BMI), waist circumference (WC) andhigh-sensitive C- reactive protein (hsCRP), fasting plasma glucose (FPG), post-prandialglucose (PPG), HbA1c and triglyceride levels (p<0.05). Neutrophil countswere positively correlated with hsCRP, FPG, HbA1c, BMI, PPG, LDL-Cholesterol(LDL-C) and microalbumin levels (p<0.05). Lymphocyte counts were positivelycorrelated with systolic blood pressure (SBP), DBP, BMI, WC and FPG, HbA1c,LDL-C and triglyceride levels (p<0.05). WBC, neutrophil and lymphocytecounts were negatively correlated with HDL-Cholesterol (HDL-C) levels(p<0.05). PDW was higher in DM group (16.65±0.59 to 16.51±0.51, p:0.043).PDW was positively correlated with age, DBP, FPG, PPG, HbA1c, LDL-C andtriglyceride levels (p<0.05). Monocyte to HDL-C ratio was higher in DM group(13.50 ± 5.34 to 10.54 ± 4.29, p<0.0001).Conclusions:In this study white blood cell, neutrophil and lymphocyte counts and PDW were higherin type 2 diabetic patients with inappropriorate glycemic management despiteinsulin therapy and they were correlated wıth cardio-metabolic risk factors. Leukocytesubtypes and PDW may be used as a marker for cardiovascular diseases in thesepatients.