177 Opere İntrakranial Meningiom Olgusunun Histopatolojik Özelliklerinin Analizi
Histopathological analysis of 177 cases with operated intracranial meningioma
Yazar: Menekşe, Güner; Gezercan, Yurdal; Ateş, Tuncay; Özsoy, Kerem Mazhar; Ökten, Ali İhsan; Demirtürk, Pelin; Adamhasan, Fulya; Güzel, Ebru; Güzel, Aslan
Dergi: Cukurova Medical Journal, Vol. 38 No. 1, 2014
Anahtar kelimeler: clinical analysis, histopathological classification, intracranial meningioma ; histopatolojik sınıflama, intrakranial meningiom, klinik analiz

AMAÇ: Kliniğimizde intrakranial kitle nedeniyle opere edilerek meningiom tanısı alan olguların histopatolojik özelliklerinin değerlendirilmesi amaçlandı.   MATERYAL VE METOD: 2007-2012 yılları arasında, kliniğimizde intrakranial meningiom tanısı alan 177 olgu  retrospektif olarak incelendi ve  yaş, cins, tümör lokalizasyonu ve histopatolojik sınıflama özellikleri analiz edildi.  BULGULAR: 177 intrakranial meningiom olgusunun % 74.6"sı kadın, % 25.4"ü erkekti ve Erkek/Kadın oranı 3.4/10 olarak bulundu. Olguların yaş aralığı 12-105 arasındaydı. En sık 51-60 yaş aralığında olduğu görüldü. Histopatolojik incelemede; 163 olgu (%92.1) WHO Grade I, 11 olgu (% 6.2) WHO Grade II, 3 olgu (%1.7)  ise WHO Grade III olarak tespit edildi. WHO Grade I olgularda sırasıyla meningotelyal, transizyonel ve psammamatöz tip en sık görülürken, Grade II olgularda atipik meningiom hakimiyeti vardı. WHO Grade II ve III olgularda erkek cinsiyet hakimiyeti mevcuttu. Olguların % 88.1"i supratentorial,  %11.9"u infratentorial iken, 1 olgu lateral ventrikül yerleşimliydi. Serideki 7 olguda (%3.9) çoğul meningiom saptandı.  SONUÇ: 177 olguluk seride intrakranial meningiomların en sık 51-60 yaş arasında görüldüğü ve en sık yerleşim yerinin konveksite olduğu saptandı. Grade I olgular daha sık kadın cinste görülürken, Grade II ve III olgularda erkek hakimiyeti mevcuttu. Ayrıca saptanan çoğul meningiomların hepsi kadın olgulardı. Grade I olgular içinde meningotelyal meningiomlar en fazla görülen alt tipi oluşturmaktaydı.

Purpose: Aim of this study is to evaluate histopathologic properties of patients with intracranial meningioma who were operated due to intracranial mass. Method: 177 cases diagnosed with intracranial meningioma were retrospectively examined in our clinic between the years of 2007-2012 and their age, sex, tumor localization, and histopathologic properties were analyzed. Results: 74.6% of 177 intracranial meningioma cases were females, 25.4% were males and the ratio of Male/Female was found 3.4/10. The age interval of the cases was between 12-105 years old. It was most frequently seen at the interval of 51-60. In histopathologic examination, 163 cases (92.1%) were noted as WHO Grade I, 11 cases (6.2%) were WHO Grade II, and 3 cases (1.7%) were WHO Grade III. While meningotelial transitional, and psammomatous type was the most frequently seen in WHO Grade I, atypical meningioma was only dominant in Grade II. In WHO Grade II and III cases, dominance of the male sex was present. While 88.1% of the cases had supratentorial localization, 11.9% had infratentorial localization, 1 case had lateral ventricle localization. In 7 cases (3.9%) of the series, multiple meningiomas were determined. Conclusion: In a series of 177 cases, intracranial meningiomas were seen between 51-60 years old and its most frequent localization was convexity. While Grade I cases were seen in the female sex, dominance of the male sex was present in Grade II and III cases. Additionally, all of multiple meningiomas detected were female cases. Meningotelial meningiomas constitute the most commonly seen subtype among Grade I cases. Key Words: Intracranial meningioma, histopathological classification, clinical study