ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki
ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki
Yazar: Coşkun, Mehmet; Haskul, İsmail; Neşelioğlu, Salim; Erel, Özcan
Dergi: Bozok Tıp Dergisi, Vol. 14 No. 1, 2024
Anahtar kelimeler: Endocrinology ; Endokrinoloji ; ASSOCIATION BETWEEN THE STAGE OF DIABETIC,RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS,Diyabetik Retinopati Evresi ile Tiyol/Disülfid HomeostazıArasındaki İlişki

Objective: This study investigate the association between the stage of retinopathy and thiol/disulfide homeostasisin patients with type 2 diabetes.Material and Methods: Group 1, 100 diabetic patients without retinopathy; Group 2, 115 patients with nonproliferativediabetic retinopathy(NPDR); and Group 3, 72 patients with proliferative diabetic retinopathy(PDR). Disulfide, native thiol levels (NTLs) and total thiol levels(TTLs), disulfide/NT ratio (index 1), disulfide/TT ratio (index 2) and NT/TT ratio (index 3) of the patients were evaluated. Patients were excluded ifthey had cardiovascular or cerebrovascular diseases, or a diagnosis of inflammatory diseases or malignancy,if they were using any medications including lipid lowering agents, vitamins, or any antioxidants, or if theyhad a history of alcohol intake or smoking.Results: There was no significant difference between the groups in terms of age and gender (p=0.098 andp=0.16, respectively). No significant difference was observed between the groups with respect to disulfidelevels (p=0.22). NTLs and TTLs were lowest in Group 1 and highest in Group 3. Significant differenceswere found in NTLs and TTLs between all groups (for NTLs, p=0.01, p=0.001 and p=0.001, respectively; forTTLs, p=0.008, p=0.001 and p=0.006, respectively). Index 1, 2 and 3 values were not significantly differentbetween Group 1 and 2 (p=0.83, p=0.43 and p=0.43, respectively), while significant differences were observedbetween Group 1 and 3 and between Group 2 and 3 (for all 3 indexes, p=0.001)Conclusion: While there was no difference between the groups in terms of disulfide levels, NTL and TTLwere found to be lower as the retinopathy stage increased.

Objective: This study investigate the association between the stage of retinopathy and thiol/disulfide homeostasisin patients with type 2 diabetes.Material and Methods: Group 1, 100 diabetic patients without retinopathy; Group 2, 115 patients with nonproliferativediabetic retinopathy(NPDR); and Group 3, 72 patients with proliferative diabetic retinopathy(PDR). Disulfide, native thiol levels (NTLs) and total thiol levels(TTLs), disulfide/NT ratio (index 1), disulfide/TT ratio (index 2) and NT/TT ratio (index 3) of the patients were evaluated. Patients were excluded ifthey had cardiovascular or cerebrovascular diseases, or a diagnosis of inflammatory diseases or malignancy,if they were using any medications including lipid lowering agents, vitamins, or any antioxidants, or if theyhad a history of alcohol intake or smoking.Results: There was no significant difference between the groups in terms of age and gender (p=0.098 andp=0.16, respectively). No significant difference was observed between the groups with respect to disulfidelevels (p=0.22). NTLs and TTLs were lowest in Group 1 and highest in Group 3. Significant differenceswere found in NTLs and TTLs between all groups (for NTLs, p=0.01, p=0.001 and p=0.001, respectively; forTTLs, p=0.008, p=0.001 and p=0.006, respectively). Index 1, 2 and 3 values were not significantly differentbetween Group 1 and 2 (p=0.83, p=0.43 and p=0.43, respectively), while significant differences were observedbetween Group 1 and 3 and between Group 2 and 3 (for all 3 indexes, p=0.001)Conclusion: While there was no difference between the groups in terms of disulfide levels, NTL and TTLwere found to be lower as the retinopathy stage increased.