Non-metastatik mide kanserli olgularda prognostik faktörler
Non-metastatik mide kanserli olgularda prognostik faktörler
Yazar: Kaçan, Turgut; Akgül Babacan, Nalan; Kılıçkap, Saadettin; Şeker, Mehmet; Yücel, Birsen; Uncu, Tunahan; Yılmaz, Ali
Dergi: Cumhuriyet Tıp Dergisi, Vol. 35 No. 3, 2012
Anahtar kelimeler: Non-metastatic gastric cancer, CEA, prognostic factors ; Non-metastatik mide kanseri, CEA, prognostik faktörler

Özet Amaç. Mide kanseri kansere bağlı ölümlerin en sık nedenlerinden biridir. Prognostik faktörler tedavi kararını etkileyebilir. Bu retrospektif çalışmada merkezimizde takip edilen non-metastatik mide kanseri olgularda prognostik faktörlerin belirlenmesi amaçlandı. Yöntem. Hasta verileri hasta dosyası ve hastane kayıtlarından elde edildi. Demografik veriler ve patolojik bulgular toplanarak veri tabanına kaydedildi. Tümör ve hastaya ait prognostik faktörlerin yanı sıra, laboratuvar parametreleri incelendi. Bulgular. Çalışmada 2009-2011 tarihleri arasında bölümümüze başvuran mide kanseri tanısı almış 120 hastanın verileri analiz edildi. Olguların yaş ortalaması 60±11 iken, hastaların 92’si (%77) erkek idi. Mide tümörü %78’inde (n=93) distal yerleşimli idi. En sık görülen evre %71 ile evre 3 idi. Tüm olguların %62’sinde lenfovasküler invazyon pozitif idi. Olguların %44’ü kötü diferansiye tümör idi. En sık ECOG performans skoru “0” (%64) görüldü. Ortanca tümör çapı 5 cm (1-15) idi. Ortanca çıkarılan lenf nodu sayısı 20 (2-54) iken, ortanca tutulmuş lenf nodu sayısı 5 (0-44) idi. Yüzde seksen hastada lenf nodu tutulumu mevcuttu. Ortanca izlem süresi 22 ay idi. Üç yıllık sağkalım oranları evre arttıkça azalmaktaydı. CEA yüksekliği, evre, lenf nodu tutulumu, performans skoru, ekstralenfatik yayılım ve anemi sağkalımı etkileyen faktörler idi. CEA yüksekliği ve evre sağkalımı etkileyen bağımsız değişkenlerdi. Sonuç. Non-metastatik mide kanserinde evre ve CEA yüksekliği sağkalımı bağımsız olarak etkilemektedir. Anahtar sözcükler: Non-metastatik mide kanseri, CEA, prognostik faktörler   Abstract Aim. Gastric cancer is one of the leading causes of cancer-related deaths. The prognostic factors may affect decision of the treatment. In this retrospective study, we aimed to determine prognostic factors for non-metastatic gastric cancer in patients who were followed-up in our centre. Method. The data were obtained from patients’ file and the hospital records. The demographic parameters and pathological findings of the patients were recorded at the database. In addition to the laboratory tests of all patients, tumor,- and patient-related prognostic factors were also evaluated. Result. Data of 120 patients with gastric cancer at followed-up in our department between 2009 and 2011 were analyzed in this study. The mean age of the patients was 60±11, and 92 (77%) were male. Seventy-eight percent of gastric cancer (n=93) were localized in the distal. The most common occurred stage was stage 3 (71%). Of patients, lymphovascular invasion was 62% and 44% had poorly differentiated tumor. The most common performance status was ECOG “0” (64%). The median tumor size was 5 cm (1-15 cm). The number of median excised lymph node was 20 (2-54) and the median involved lymph node was 5 (0-44). Eighty percent of patients were lymph node positive. The median follow-up period was 22 months. The 3-year survival rates were decreasing according to stage. CEA elevation, stage, node involvement, performance status, extralymphatic extension, and anemia were prognostic factor for survival. CEA and the stage of disease was independently prognostic factors for survival. Conclusion. Stage and higher CEA independently affect survival in non-metastatic gastric cancer. Keywords: Non-metastatic gastric cancer, CEA, prognostic factors

Aim. Gastric cancer is one of the leading causes of cancer-related deaths. The prognostic factors may affect decision of the treatment. In this retrospective study, we aimed to determine prognostic factors for non-metastatic gastric cancer in patients who were followed-up in our centre. Method. The data were obtained from patients’ file and the hospital records. The demographic parameters and pathological findings of the patients were recorded at the database. In addition to the laboratory tests of all patients, tumor,- and patient-related prognostic factors were also evaluated. Result. Data of 120 patients with gastric cancer at followed-up in our department between 2009 and 2011 were analyzed in this study. The mean age of the patients was 60±11, and 92 (77%) were male. Seventy-eight percent of gastric cancer (n=93) were localized in the distal. The most common occurred stage was stage 3 (71%). Of patients, lymphovascular invasion was 62% and 44% had poorly differentiated tumor. The most common performance status was ECOG “0” (64%). The median tumor size was 5 cm (1-15 cm). The number of median excised lymph node was 20 (2-54) and the median involved lymph node was 5 (0-44). Eighty percent of patients were lymph node positive. The median follow-up period was 22 months. The 3-year survival rates were decreasing according to stage. CEA elevation, stage, node involvement, performance status, extralymphatic extension, and anemia were prognostic factor for survival. CEA and the stage of disease were independently prognostic factors for survival. Conclusion. Stage and higher CEA independently affect survival in non-metastatic gastric cancer.