Inflammatory Biomarkers as Potential Mediators for the Association between Periodontal and Systemic Disease in Kosovo
Inflammatory Biomarkers as Potential Mediators for the Association between Periodontal and Systemic Disease in Kosovo
Yazar: Sllamnikudalipi, Zana; Dragidella, Fatmir; Disha, Metush; Meqa, Kastriot; Begolli, Luljeta; Begolli, Gramos
Dergi: Journal Of International Dental And Medical Research, Vol. 6 No. 1, 2014
Anahtar kelimeler: Periodontal disease, interleukin–1 beta, interleukin–6, tumour necrosis factor alpha, high sensitivity- C reactive protein.

The possibility of a connection between oral cavity and systemic diseases has been intensively researched in recent years. The aim of this study was to compare the serum levels of highsensitivity C reactive protein (hs-CRP), interleukin-1 beta (IL1β), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNFα) between patients with and without periodontitis. Clinical periodontal parameters: gingival index, the dental plaque index, the probing depth, the clinical attachment level, the bleeding index and the tooth mobility index were measured at six sites per tooth in seventy-five subjects with periodontitis and in thirty-five periodontally healthy subjects. Serum levels of hs-CRP and inflammatory cytokines were assessed via Enzyme-Linked ImmunoSorbent Assay. Inter-group significance was determined by the Student’s t-test, x2-test and Mann-Whitney test. The concentrations of each biomarker (control group vs. periodontal disease group) were as follows: hsCRP (0.5 ± 0.6 vs. 2.5 ± 2.6, respectively), IL-1β (2.1 ± 2.2 vs. 7.0 ± 11.6, respectively), IL- 6 (1.9 ± 1.6 vs. 3.7 ± 4.4, respectively) and TNF- α (64.6 ± 72.3 vs. 80.0 ± 73.1, respectively). The differences between the groups showed statistical significance at p < 0.05. Periodontal disease was associated with increased circulating concentrations of hs-CRP and inflammatory cytokines. Clinical article (J Int Dent Med Res 2013; 6: (1), pp. 1-5)

The possibility of a connection between oral cavity and systemic diseases has been intensively researched in recent years. The aim of this study was to compare the serum levels of highsensitivity C reactive protein (hs-CRP), interleukin-1 beta (IL1β), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNFα) between patients with and without periodontitis. Clinical periodontal parameters: gingival index, the dental plaque index, the probing depth, the clinical attachment level, the bleeding index and the tooth mobility index were measured at six sites per tooth in seventy-five subjects with periodontitis and in thirty-five periodontally healthy subjects. Serum levels of hs-CRP and inflammatory cytokines were assessed via Enzyme-Linked ImmunoSorbent Assay. Inter-group significance was determined by the Student’s t-test, x2-test and Mann-Whitney test. The concentrations of each biomarker (control group vs. periodontal disease group) were as follows: hsCRP (0.5 ± 0.6 vs. 2.5 ± 2.6, respectively), IL-1β (2.1 ± 2.2 vs. 7.0 ± 11.6, respectively), IL- 6 (1.9 ± 1.6 vs. 3.7 ± 4.4, respectively) and TNF- α (64.6 ± 72.3 vs. 80.0 ± 73.1, respectively). The differences between the groups showed statistical significance at p < 0.05. Periodontal disease was associated with increased circulating concentrations of hs-CRP and inflammatory cytokines. Clinical article (J Int Dent Med Res 2013; 6: (1), pp. 1-5)