Deneysel olarak oluşturulan defektlerde titanyum partikülleri ve değişik greft materyallerinin kemik iyileşmesi üzerine etkilerinin karşılaştırılması
Comparison of the effects of titanium particles and different graft materials on bone healing in experimentally constituted defects
Yazar: HÜSEYİN AYKUT ÖZYİĞİT
Danışman: DOÇ. DR. KERİM ORTAKOĞLU
GATA / Sağlık Bilimleri Enstitüsü / Ağız, Diş, Çene Hastalıkları ve Cerrahisi Ana Bilim Dalı
Derece: Doktora, 2007
Konu: Diş Hekimliği = Dentistry
Dizin: Kemik defektleri = Bone defects ; Kemik rejenerasyonu = Bone regeneration ; Titanyum = Titanium ; Transplantlar = Transplants

Özet:
Çalısmamizin amaci; titanyum partikülleri kullanarak kemik defektinidoldurmak; bu materyalin olusturdugu gati etrafinda yeni kemik olusturmakve sonu? olarak bu uygulamayi greftleme yöntemleri arasina koymaktir. Buyöntemin mevcut yöntemlere alternate, biyouyumlu ve daha ucuz biruygulama oldugu dusunulmektedir.Arastirmamizda ü? adet erkek domuz denek hayvani olarak kullanilmistir.Deneklerin her iki tibiasinda da alti adet suni defekt olusturulmustur. Budefektlerin igine titanyum, titanyum-kalsiyum hidroksit kansimi, (3-TCP,biyoaktif cam seramikleri ve HA yerlestirilmistir. Son defekt ise kontrol amaciile bos birakilmistir. Butun denekler ?ah§manin 16. haftasinda sakrifiyeedilerek tibialar ampüte edilmi§ ve kesme inceltme sistemi kullanilarakhistolojik kesitler hazirlanmi§tir.Histopatolojik incelemeyle elde edilen verilere gore en iyi iyile§menin kontrolve HA grubunda olup, daha sonra ise sirasi ile TCP, biyoaktif cam seramik,titanyum ve titanyum-kalsiyum hidroksit kansiminda oldugu saptanmistir.Titanyumun partikul boyut veya seklinin degistirilmesi, yüzey modifikasyonu,PRP, BMP gibi faktorlerle beraber uygulanmasi, kollajenle kaplanmasi veotojen greft ya da kanla karistinlmasi gibi muamelelere tabi tutularak defektalanina yerle§tirilmesinin kemik iyile§mesini olumlu etkileyecegi sonucunavanlmi§tir.Anahtar kelimeler :Titanyum, Greft materyalleri, Kemikiyilesmesi, Kemik Defekti.

Abstract:
The aim of this study is to fill the bone defects with titanium particles andinduce new bone formation around this artificial scaffold and eventuallyestablish this application among grafting techniques. This method is thoughtto be an alternative to the existing materials, biocompatible, and cheap.In this research three male porcine were used as experimental subjects. Sixartificial defects were created on both tibia bones of the subjects. Thosedefects were filled with titanium particles, titanium particles-calcium hydroxidemixture beta-TCP, bioactive glass ceramic, and HA. Final defect was leftunfilled as a control. All subjects were sacrificed on the 16th week of theThe aim of this study is to fill the bone defects with titanium particles andinduce new bone formation around this artificial scaffold and eventuallyestablish this application among grafting techniques. This method is thoughtto be an alternative to the existing materials, biocompatible, and cheap.In this research three male porcine were used as experimental subjects. Sixartificial defects were created on both tibia bones of the subjects. Thosedefects were filled with titanium particles, titanium particles-calcium hydroxidemixture, (3-TCP, bioactive glass ceramic, and HA. Final defect was leftunfilled as a control. All subjects were sacrificed on the 16th week of theexperiment and tibia bones were amputated, subsequently histologicsections were prepared using the cutting and grinding technique.According to the data acquired via histopathologic examination, the bestresults were seen in the control and HA group, and respectively (3-TCP,bioactive glass ceramic, titanium particles and titanium particles-calciumhydroxide mixture groups.It was concluded that filling the defects with titanium particles after subjectingto processes such as change in size or shape of the particles, surfacemodification, application with factors like PRP or BMP, coating with collagen,and mixing with outograft or blood may improve bone healing.Keywords :Titanium, Graft Materials, Bone Healing, BoneDefect.