Çocuk kliniğinde pnömoni tanısı ile tedavi edilen hastalarda serum 25(OH) D vitamin düzeylerinin değerlendirilmesi /
Yazar: DENİZ ACIOĞLU
Danışman: DOÇ. DR. ŞİRİN GÜVEN
Sağlık Bilimleri Üniversitesi / İstanbul Ümraniye Eğitim ve Araştırma Hastanesi / Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
Derece: Tıpta Uzmanlık, 2017
Konu: Çocuk Sağlığı ve Hastalıkları = Child Health and Diseases
Dizin: Göğüs hastalıkları = Thoracic diseases ; Pnömoni = Pneumonia ; Solunum sistemi = Respiratory system ; Solunum yolları enfeksiyonları = Respiratory tract infections ; Tedavi = Treatment ; Vitamin D = Vitamin D ; Vitamin D eksikliği = Vitamin D deficiency ; Çocuklar = Children

Özet:
Çocuklarda toplum kökenli pnömoni (TKP), özellikle gelişmekte olan ülkelerde morbidite ve mortalitenin en sık nedenidir. Çocuklarda düşük D vitamini ile alt solunum yolu enfeksiyonları arasında ilişki olduğu gösterilmiştir. Çalışmamızda, toplum kökenli pnömoni (TKP) tanısı konulan çocuklarda serum 25 hidroksi D vitamini (25OH D) düzeylerinin araştırılması ve sağlıklı kontrol grubu ile karşılaştırılması amaçlanmıştır.

Abstract:
OBJECTIVE: Community-acquired pneumonia (CAP) is the most common cause of
morbidity and mortality in children, particularly in developing countries. It has been shown in
children that there is a relationship between low D vitamine and lower respiratory tract
infections. In our study, we aimed to investigate the serum 25-hydroxyvitamin D (25 (OH) D)
levels in children who were diagnosed with community-acquired pneumonia (CAP) and
compared them with a healthy control group.
MATERIAL AND METHOD: Within our study, we investigated the complete blood
count (CBC), C reactive protein levels (CRP), sedimentation rate and 25-hydroxyvitamin D 25
(OH) D vitamin levels of 79 patients between 1 and 14 years old who were followed up and
treated in Ümraniye Training and Research Hospital Children's Clinic between June 2016 and
December 2016. We accessed the patient records from our hospital's Hospital Information
System (HIS). Patients with clinical rickets, malnutrition and chronic lung disease were not
included in the study. The control group consisted of 79 children aged between 1 and 14 years
who were admitted to the hospital during our study period for reasons other than lower
respiratory tract infection. The control group was not matched in terms of age and gender with
the cases in the patient group. Serum 25 (OH) D vitamin levels were measured by an
immunoassay. Vitamin D deficiency was accepted as 25 (OH) D <20 ng / ml, vitamin D
insufficiency as 25 (OH)D: 21-29 ng / ml and vitamin D sufficiency as 25 (OH)D: 30-100 ng /
ml.
RESULTS: The mean age of the patients with pneumonia was 7.8 ± 11.3, the mean age of
the cases in the control group was 11.7 ± 7.0. 33. Thirty three (41.8%) of these were male and
46 (58.2%) were female. A positive statistically significant correlation between vitamin D and
WBC was found. There was a statistically significant difference between the groups in terms
of 25 (OH) D levels (Fisher's Exact p<0,05) and 25 (OH) D levels below 10 ng/ml (Ki-Square
p = 0.01).
CONCLUSION: In our study, a significant relationship between Pneumonia and vitamin D
deficiency was found. Patients with subclinical D vitamin deficiency, especially 25OH D level
<10 ng / mL, carry an increased risk of lower respiratory tract infections.