Sisplatin kullanan hastalarda statik posturografi bulgularının ve işitmenin değerlendirilmesi
Evaluation of static posturography findings and hearing in patients using cisplatin
Yazar: ARZU TATAR
Danışman: DOÇ. DR. BANU MÜJDECİ
Ankara Yıldırım Beyazıt Üniversitesi / Sağlık Bilimleri Enstitüsü / Odyoloji ve Konuşma Bozuklukları Ana Bilim Dalı / Odyoloji ve Konuşma Bozuklukları Bilim Dalı
Derece: Yüksek Lisans, 2021
Konu: Kulak Burun ve Boğaz = Otorhinolaryngology (Ear-Nose-Throat)
Dizin: Duruş = Posture ; Düşme kazaları = Accidental falls ; Ototoksisite = Ototoxicity ; Postural denge = Postural balance ; Sisplatin = Cisplatin ; Vestibüler sistem = Vestibular system ; İşitme = Hearing

Özet:
Objective; the purpose of this study was to examine the cochleotoxic effects of
cisplatin with high-frequency audiometry, to investigate the effects of posturography
and cisplatin on balance, and to compare the static posturography results of patients
who developed cochleotoxicity according to ASHA criteria and those who did not.
Methods; thirty cancer patients were included in the study. Before starting
cisplatin and one day after the end of the treatment; Pure tone audiometry, speech
audiometry, high-frequency audiometry, acoustic immitansmetry, and posturography
tests were performed.
Findings; according to ASHA criteria, ototoxicity developed in 17 (56.6%) of
30 patients. Tetrax IBSTM stability index showed statistical differences after treatment
in all eight sensory conditions in Group 2, and in NC, PO and PC in Group 1 (p<0.05).
A statistically significant difference was found in the weight distribution index values
after treatment in PC, HB and HF in Group 1, and in NC, PC, HL, HB, HF in Group 2
(p<0.05). In Fourier index analysis, the postural control performance in Group 2 (F2-
4), (F5-6), (F7-8) frequencies, in Group 1, (F5-6) and (F7-8) frequencies compared
with pre-treatment significant deterioration was detected after treatment (p<0.05).
When comparing the post-treatment Fourier index values between the groups with and
without hearing loss (F2-4), a significant difference was found in the frequency range
of NC, PO, PC and HL, HB, HF (p<0.05).
Results; deviations in these frequencies indicate that the somatosensory and
central nervous systems are affected. These results may indicate the coexistence of
cochlear toxicity and vestibular toxicity. The deterioration of balance performance in
the patient group who did not develop hearing loss compared top re-treatment shows
that the patient who received cisplatin without hearing loss were also at risk in terms
of balance. As a result, it is recommended to evaluate balance functions along with
hearing in the routine follow-up of patients taking cisplatin.

Abstract:
Objective; the purpose of this study was to examine the cochleotoxic effects of
cisplatin with high-frequency audiometry, to investigate the effects of posturography
and cisplatin on balance, and to compare the static posturography results of patients
who developed cochleotoxicity according to ASHA criteria and those who did not.
Methods; thirty cancer patients were included in the study. Before starting
cisplatin and one day after the end of the treatment; Pure tone audiometry, speech
audiometry, high-frequency audiometry, acoustic immitansmetry, and posturography
tests were performed.
Findings; according to ASHA criteria, ototoxicity developed in 17 (56.6%) of
30 patients. Tetrax IBSTM stability index showed statistical differences after treatment
in all eight sensory conditions in Group 2, and in NC, PO and PC in Group 1 (p<0.05).
A statistically significant difference was found in the weight distribution index values
after treatment in PC, HB and HF in Group 1, and in NC, PC, HL, HB, HF in Group 2
(p<0.05). In Fourier index analysis, the postural control performance in Group 2 (F2-
4), (F5-6), (F7-8) frequencies, in Group 1, (F5-6) and (F7-8) frequencies compared
with pre-treatment significant deterioration was detected after treatment (p<0.05).
When comparing the post-treatment Fourier index values between the groups with and
without hearing loss (F2-4), a significant difference was found in the frequency range
of NC, PO, PC and HL, HB, HF (p<0.05).
Results; deviations in these frequencies indicate that the somatosensory and
central nervous systems are affected. These results may indicate the coexistence of
cochlear toxicity and vestibular toxicity. The deterioration of balance performance in
the patient group who did not develop hearing loss compared top re-treatment shows
that the patient who received cisplatin without hearing loss were also at risk in terms
of balance. As a result, it is recommended to evaluate balance functions along with
hearing in the routine follow-up of patients taking cisplatin.