Majör depresyonlu hastaların polimorf nüveli lökosit fonksiyonları üzerine antidepresan ilaç tedavisinin etkisinin araştırılması
Investigation of antidepressant drug treatment effect on polymorphonuclear leukocyte functions of patients with major depression
Yazar: DİLŞAD YURDAKUL
Danışman: Y.DOÇ.DR. ÜMRAN SOYOĞUL GÜRER
Marmara Üniversitesi / Sağlık Bilimleri Enstitüsü / Farmasötik Mikrobiyoloji Ana Bilim Dalı
Derece: Yüksek Lisans, 2006
Konu: Allerji ve İmmünoloji = Allergy and Immunology ; Mikrobiyoloji = Microbiology ; Psikiyatri = Psychiatry

Özet:
ÖZETdDOÃÃºPDPÃ]GD 0DM|U 'HSUHV\RQ KDVWDODUÃQGD Q \DÃº RUWDODPDVÃDQWLGHSUHVDQ LODoODUÃQ 3ROLPRUI 1ÂYHOL /|NRVLW )RQNVL\RQODUÃ VHUXP IROLN DVLW %12YLWDPLQL NRUWL]RO oLQNR EDNÃU GÂ]H\OHUL YH KHPRJUDP GHÃ·HUOHUL Â]HULQH HWNLVLQLQJ|VWHULOPHVLDPDoODQPÃÃºWÃUPNL'ler ( 1 X 107 hücre / ml ) EDT$Â¶OÃ YHQ|] NDQGDQ ILFROO-hypaque gradient\|QWHPL\OHD\UÃOPÃÃºWÃU)DJRVLWR]YHKÂFUHLoL|OGÂUPHDNWLYLWHVLWD\LQLQGH$OH[DQGHUYHDUNÂµQÃQ\|QWHPLGHÃ·LÃºWLULOHUHNNXOODQÃOPÃÃºWÃU0' KDVWDODUÃQÃQ 31/Â¶OHULQLQ IDJRVLWLN DNWLYLWHVL VDÃ·OÃNOÃ J|QÂOOÂOHUOH Q \DÃºRUWDODPDVÃ D\QÃ GÂ]H\GH KÂFUH LoL |OGÂUPH DNWLYLWHVL VDÃ·OÃNOÃ J|QÂOOÂOHUGHQ GÂÃºÂNEXOXQPXÃºWXU0'KDVWDODUÃQÃQ31/Â¶OHULQLQIDJRVLWLNDNWLYLWHVLD\OÃNDQWLGHSUHVDQLODoWHGDYLVLVRQUDVÃ WHGDYL |QFHVLQH J|UH DQODPVÃ] RODUDN DUWPÃÃºWÃU +ÂFUH LoL |OGÂUPH DNWLYLWHVL LVHHWNLOHQPHPLÃºWLUS!5HIHUDQV GHÃ·HUOHU LoHULVLQGH IROLN DVLW GÂ]H\L DQODPVÃ] RODUDN NRUWL]RO GÂ]H\LDQODPOÃ RODUDN DUWDUNHQ %12 YLWDPLQ oLQNR GÂ]H\OHUL DQODPVÃ] RODUDN D]DOPÃÃº EDNÃUdüzeyi etkilenmHPLÃºWLUD\OÃN WHGDYL VRQUDVÃ (2 GHÃ·HUL 3/7 VD\ÃODUÃ WHGDYL |QFHVLQH J|UH :%&1(3/7VD\ÃODUÃ(2GHÃ·HUOHULGHD\OÃNWHGDYLVRQUDVÃGHÃ·HUOHUHJ|UHDQODPOÃRODUDNDUWPÃÃºWÃU S 'LÃ·HU KHPDWRORMLN SDUDPHWUHOHU UHIHUDQV GHÃ·HUOHU LoHULVLQGH DQODPVÃ]RODUDNGHÃ·LÃºPLÃºWLU6RQXo RODUDN DQWLGHSUHVDQ LODoODUÃQ 31/Â¶OHULQ IDJRVLWLN DNWLYLWHVLQL DUWWÃUGÃÃ·ÃKÂFUH LoL |OGÂUPH DNWLYLWHVLQL HWNLOHPHGLÃ·L oDOÃÃºWÃÃ·ÃPÃ] GLÃ·HU SDUDPHWUHOHUL LVH UHIHUDQVGHÃ·HUOHULoHULVLQGHGHÃ·LÃºWLUGLÃ·LWHVSLWHGLOPLÃºWir.Anahtar Kelimeler: Antidepresan, depresyon, PNL, fagositoz, çinko

Abstract:
SUMMARYInvestigation of Antidepressant Drug Treatment Effect on PolymorphonuclearLeukocyte Functions of Patients With Major DepressionIn this study our aim was to investigate the effect of antidepressant drugs onpolymorphonuclear leukocyte functions, serum folic acid, vitamin B12, cortisol, zinc,copper levels and hemogram parameters of patients (n=12 average age 40) with MajorDepression.PMNs ( 1 X 107 cell /ml) were isolated by ficoll-hypaque gradient centrifugationmethod from venous blood with EDTA. Phagocytosis and intracellular killing activitywere assayed by modifying Alexander?s method (1968)The phagocytic activity of PMN of MD patients was found in the same level ashealthy volunteers (n=10, averadge age 35), the intracellular killing activity was foundlower than that of healthy volunteers.The PMN?s phagocytic activity of patients with Major Depression after 2 monthsof antidepressant drug treatment unsignificantly increased when compared with thosebefore treatment. The intracellular killing activity was not effected (p>0,05).Within the reference values, as the level of folic acid unsignificantly, level ofcortisol significantly increased, the levels of vitamin B12, zinc unsignificantly decreased,level of copper was not effected.After 2 months of treatment EO% value, PLT counts when compared with thosebefore treatment, WBC, NE, PLT counts, EO% values when compared with those after 1months of treatment significantly increased. (p<0,05) Other hematological parametersunsignificantly changed within reference values.In conclusion, we found that antidepressant drugs increased the phagocyticactivity of PMNs, did not effect the intracellular killing activity, within reference valueschanged the parameters we studied on.Key words: Antidepressant, depression, PMN, phagocytosis, zinc