Periton diyalizi hastalarında staphylococcus aureus ve vankomisin dirençli enterokok taşıyıcılığının sürveyansı ve bu mikroorganizmalarla gelişen invaziv infeksiyonların değerlendirilmesi
Surveillance of staphylococcus aureus and vancomycin resistant enterococci carriage in peritoneal dialysys patients and evaluation of invasive innfections caused by these microorganism
Yazar: EMİNE KARKAÇ
Danışman: Y.DOÇ.DR. ELİF DOYUK KARTAL
Eskişehir Osmangazi Üniversitesi / Tıp Fakültesi / Klinik Bakteriyoloji ve Enfeksiyon Hastalıkları Ana Bilim Dalı
Derece: Tıpta Uzmanlık, 2006
Konu: Klinik Bakteriyoloji ve Enfeksiyon Hastalıkları = Clinical Microbiology and Infectious Diseases

Özet:
ABSTRACTKarkaç E, Surveillance of Staphylococcus aureus and vancomycin- resistantenterococci carriage in peritoneal dialysis patients and evaluation of invasiveinfections caused by these microorganisms. Eskişehir Osmangazi UniversityFaculty of Medicine,Medical Speciality Thesis in Department ofClinical Bacteriology and Infection Diseases, Eskişehir, 2006. S.aureuscarriage has a key role on etiology and pathogenesis of infections. Nasal S.aureuscarriage is more prevelant in some patients groups. VRE has an important role innosocomial infections recently. We aimed to define nasal S.aureus carriage andcolonisation around catheter. We also aimed to define VRE carriage in stool andassociation between S.aureus, VRE carriage and invasive infections.Study was performed at the patients of Osmangazi University, unit of dialysisbetween 01.10.2005 and 31.03.2006. Nasal S.aureus carriage and colonisationaround catheter, VRE carriage in stool were evaluated monthly. Invasive infectionsand association between infections and carriage was investigated.The number of patients followed by CAPD programme was 50 at thebeginning of the period. 15 of patients couldn't completed the program.At least one site of body S.aureus carriage were detected 28%, 17 % werenasal carriers, 6 % were catheter site carriers, 6 % were carrier for both. 19peritonitis attacks developed in 31% of patients. In these attacks, KNS,Corynebacterium spp, and K.oxytoca were isolated.In the patients who couldn't complete the CAPD programme, at least one siteof body S.aureus carriage were detected 60%, 47% were nasal carriers, 7% werecatheter carriers, 7% were carriers for both . VRE was isolated at one patient. Tenperitonitis attacks developed in 53% of patients. Tunnel infection was detected in6% of them. CNS, A. faecalis, C.albicans were isolated in the peritonitis attacks.P.aeruginosa was isolated in the tunnel infection. Eight patients in CAPDprogramme couldn't complete study because of catheter loss. They were passed tohaemodialysis. Catheter loss was related with peritonitis, tunnel infection, andfunctional problems. Seven of them were carrier for S.aureus. Carriers had increasedrisk for catheter loss (pâ¤0,05).Key words: S.aureus carriage, VRE carriage, Peritoneal dialysis

Abstract:
ABSTRACTKarkaç E, Surveillance of Staphylococcus aureus and vancomycin- resistantenterococci carriage in peritoneal dialysis patients and evaluation of invasiveinfections caused by these microorganisms. Eskişehir Osmangazi UniversityFaculty of Medicine,Medical Speciality Thesis in Department ofClinical Bacteriology and Infection Diseases, Eskişehir, 2006. S.aureuscarriage has a key role on etiology and pathogenesis of infections. Nasal S.aureuscarriage is more prevelant in some patients groups. VRE has an important role innosocomial infections recently. We aimed to define nasal S.aureus carriage andcolonisation around catheter. We also aimed to define VRE carriage in stool andassociation between S.aureus, VRE carriage and invasive infections.Study was performed at the patients of Osmangazi University, unit of dialysisbetween 01.10.2005 and 31.03.2006. Nasal S.aureus carriage and colonisationaround catheter, VRE carriage in stool were evaluated monthly. Invasive infectionsand association between infections and carriage was investigated.The number of patients followed by CAPD programme was 50 at thebeginning of the period. 15 of patients couldn?t completed the program.At least one site of body S.aureus carriage were detected 28%, 17 % werenasal carriers, 6 % were catheter site carriers, 6 % were carrier for both. 19peritonitis attacks developed in 31% of patients. In these attacks, KNS,Corynebacterium spp, and K.oxytoca were isolated.In the patients who couldn?t complete the CAPD programme, at least one siteof body S.aureus carriage were detected 60%, 47% were nasal carriers, 7% werecatheter carriers, 7% were carriers for both . VRE was isolated at one patient. Tenperitonitis attacks developed in 53% of patients. Tunnel infection was detected in6% of them. CNS, A. faecalis, C.albicans were isolated in the peritonitis attacks.P.aeruginosa was isolated in the tunnel infection. Eight patients in CAPDprogramme couldn?t complete study because of catheter loss. They were passed tohaemodialysis. Catheter loss was related with peritonitis, tunnel infection, andfunctional problems. Seven of them were carrier for S.aureus. Carriers had increasedrisk for catheter loss (pâ¤0,05).Key words: S.aureus carriage, VRE carriage, Peritoneal dialysis