Nodüler guatr ve otoimmün troid hastalıklarında benign meme patolojileri sıklığı
Prevalence of Benign Breast Diseases in Nodular Goiter and Autoimmune Thyroid 
Diseases
Yazar: TEKİN GÜNEY
Danışman: DOÇ. DR. ALPTEKİN GÜRSOY
Başkent Üniversitesi / Tıp Fakültesi / İç Hastalıkları Ana Bilim Dalı
Derece: Tıpta Uzmanlık, 2009
Konu: Endokrinoloji ve Metabolizma Hastalıkları = Endocrinology and Metabolic Diseases

Özet:
Tiroid hastahklan ile benign ve malign meme hastahklan arasmdaki i1i~kiye dair
kamtlar giderek artmaktadtr. Benign meme hastahklannda tiroid hastahklan slkhgmm
arttlgl ve farkh tiroid hastahklannm da benign ve malign meme hastahklan ve bu
hastahklann sonlamml ile i1i~kili oldugu gosterilmi~tir. Tiroid ve benign meme hastahklan
arasmdaki i1i~kiyi ara~tIran c;ah~malarda slkhkla, benign meme hastahklannda tiroid
otoimmiinitesi ve fonksiyonlan ara~tmlml~tlr. Bu c;alt;;mada nodUler tiroid hastahgl ve
Hashimoto tiroiditi olan hastalarda benign meme hastahklan slkhgmm ara~tmlmasl
amac;lanml;;ttr .
<;ah;;maya 71 nodUler tiroid hastahgl olan ve 95 Hashimoto tiroiditi olan hasta ve
benzer ya;; arahgmda 72 saghkh birey dahil ediImi;;tir. KatIhmctlann aynntlh klinik
degerlendirmesinin ardmdan serum tiroid stimUle edici hormon, serbest T3, serbest T4,
tiroid peroksidaz antikor diizeyleri incelenmi;; ve tiroid ve olasl meme patolojisinin
belirlenmesi amaclyla tiroid ve meme ultrasonografisi uyguIanml;;tlr.
<;ah;;mada nodUler tiroid hastaIanmn %55.7'sinde, Hashimoto tiroiditi hastalannm
%47.4'iinde ve kontrol grubunun %29.2'sinde benign meme hastahgl saptanml;;ttr.
NodUler tiroid hastahkIan ve Hashimoto tiroiditinde benign meme hastahkIan slkhgmm
anIamh olarak arttIgl gosterilmi;;ti1' (straslyla p O.05).
<;ah;;ma sonucu benign meme hastahkIan ve tiroid hastahklan arasmdaki ili;;kiyi
destekier niteliktedir. Bu bulgu klinik pratikte nodUler ya da otoimmiin tiroid hastahgl olan
kadmiarda, olasl meme patolojisi yoniinden de tarama yapllmasl gerekligini ortaya
koymasl yoniinden onem ta;;lmaktadtr.
Anahtar Kelimeler: NodUler tiroid hastahklan, Hashimoto tiroiditi, Benign meme
hastahkIan
IV

Abstract:
The evidence regarding association between thyroid diseases and benign and malign
breast diseases is increasing. It has been shown that thyroid disorders are more frequent in
those with benign breast diseases and that different thyroid diseases have associations with .
benign and malign breast diseases and their outcomes. The studies exploring the
relationship between thyroid and breast diseases usually have focused on thyroid
autoimmunity and functions. In this study, we aimed to reveal the frequency of benign
breast conditions in patients with nodular thyroid disease and Hashimoto's disease.
Seventy-one women with nodular thyroid disease, ninety-five women with
Hashimoto's disease and seventy-two healthy people as a control group were included in
the study. After a detailed clinical assessment of the participants, serum thyroid stimulating
hormone, free triiodothyronine, free thyroxine and thyroid peroxidase autoantibody levels
were measured, and thyroid and breast ultrasonography were performed by a single
operator in order to determine thyroid and breast pathology.
Benign breast diseases were detected in 55.7 % of patients with nodular thyroid
diseases, in 47.4 % of those with Hashimoto's disease and 29.2 % of control group in the
study. The results showed that the frequency of benign breast diseases was significantly
higher in nodular thyroid disease and Hashimoto's disease than the control group (p O.05).
The results of our study supports the association between benign breast diseases and
thyroid diseases. An important implication of this finding is demonstration of the necessity
of scanning for potential breast pathology in women with nodular or autoimmune thyroid
disease in clinical practice.
Key Words: Nodular thyroid disease, Hashimoto's disease, benign breast diseases