Tip 2 diabetes mellitus hastalarında bir inflamasyon kriteri olarak crp/albümin oranı ile diyabet parametrelerinin korelasyonu
Correlation of diabetes parameters with crp/albumin ratio as an inflammation criteria in type 2 diabetes mellitus patients
Yazar: SERHAT KALKAN
Danışman: PROF. DR. KADİR KAYATAŞ
Sağlık Bilimleri Üniversitesi / İstanbul Haydarpaşa Numune Eğt. ve Arş. Hastanesi / İç Hastalıkları Ana Bilim Dalı / İç Hastalıkları Bilim Dalı
Derece: Tıpta Uzmanlık, 2024
Konu: İç Hastalıkları = Internal diseases

Özet:
Giriş: CRP/Albümin oranının vücuttaki inflamasyonu göstermede tek başına 
CRP'ye göre daha etkin bir parametre olup olmadığı birçok konuda araştırılmıştır. 
Diabetes Mellitus kronik inflamatuar süreçlerle seyreden bir hastalıktır. Çalışmamızda 
CRP/Albümin oranı ile Diabetes Mellitus parametreleri arasında korelasyon olup 
olmadığı belirlenmeye çalışılmıştır.
Materyal ve Metod: Çalışmamızda 01/01/2010-01/04/2023 tarihleri arasında 
Sağlık Bilimleri Üniversitesi Haydarpaşa Numune Sağlık Uygulama ve Araştırma 
Merkezine başvuran hastalar retrospektif olarak taranarak 55 tip 2 DM hastası ve 55 
DM olmayan hasta seçilmiştir. Tip 2 DM grubu kendi içinde HbA1c %6,5-7 ve 
%7 %7) olarak 
ayrılıp alt grup analizi yapıldığında HbA1c ile CAR arasında istatistiksel olarak 
anlamlı korelasyon bulunmamıştır.

Abstract:
Objective: The CRP/Albumin ratio is being investigated in many areas to 
determine whether it is a more effective parameter than CRP alone in indicating 
inflammation in the body. Diabetes Mellitus is a disease characterized by chronic 
inflammatory processes. In our study, it was aimed to determine whether there is a 
correlation between the CRP/Albumin ratio and Diabetes Mellitus parameters.
Material and Methods: Patients who applied to the Haydarpaşa Numune 
Health Practice and Research Center of the Health Sciences University between 
01/01/2010 and 01/04/2023 were retrospectively screened for our study. Fifty-five type 
2 DM patients and 55 non-DM patients were selected. The Type 2 DM group was 
further divided into %6.5 %7, and correlation analysis was 
performed. The patients included in the study were evaluated retrospectively, and their 
age, duration of diabetes, height, weight, body mass index, chronic diseases, 
medications used, fasting blood glucose, postprandial blood glucose, CRP, albumin, 
HbA1c, urea, creatinine values were recorded, and the CRP/Albumin ratio was 
determined. Analyses were performed using IBM SPSS version 22.0, with statistical 
significance set at p<0.05.
Results: In the Type 2 DM group, the mean albumin level was found to be 4.4 
± 0.3 g/dL, CRP (C-reactive protein) level was 3.29 ± 2.20 mg/L, and CRP/Albumin 
ratio was 0.75 ± 0.48. In the control group, the mean albumin level was 4.6 ± 0.3 g/dL, 
CRP level was 1.45 ± 1.20 mg/L, and CRP/Albumin ratio was 0.31 ± 0.26.
Conclusion: When diabetic patients and non-diabetic patients were compared, 
CAR was found to be significantly elevated in the diabetic group. However, when 
diabetic patients were divided into controlled diabetes (HbA1c < 7%) and uncontrolled 
diabetes (HbA1c > 7%) and subgroup analysis was conducted, no statistically 
significant correlation was found between HbA1c and CAR.