Koklear implantlı çocuklarda P1 latansının incelenmesi
P1 latency in cochlear implanted children
Yazar: EBRU KÖSEMİHAL
Danışman: PROF.DR. FERDA AKDAŞ
Marmara Üniversitesi / Sağlık Bilimleri Enstitüsü / Kulak Burun Boğaz Ana Bilim Dalı
Derece: Yüksek Lisans, 2007
Konu: Kulak Burun ve Boğaz = Otorhinolaryngology (Ear-Nose-Throat)

Özet:
Bu tezin amac., koklear implantasyon uygulanan çocuklarda santral i/itsel sisteminmatürasyonunun P1 latans. ile incelenmesi ve erken dönemde uygulanan implantasyonile normal i/iten ya/.tlar.n.n santral i/itsel sistemine benzer geli/imler gösteripgöstermedi7ini ara/t.rmakt.r. Çal./maya normal i/iten, 9 ay-7 ya/ aras. (ortalama 4,2ya/) 19 çocuk ile 1-7 ya/ aras. implante edilmi/ olan 16 çok ileri derecede sensor.-neural i/itme kay.pl. çocuk dahil edilmi/tir. Normal i/iten çocuklarda herhangi birnörolojik, lisan ve otolojik problemin olmamas. gözönüne al.nm./t.r. Koklear implantl.çocuklar 2-11 ya/ aras.ndad.r. Koklear implantl. çocuklarda do7u/tan i/itme kayb.olma ve en az dört ayd.r implant kullanm./ olma /art. aranm./t.r.Bilgisayarda i/lemlenen /da/ konu/ma hecesi kullan.larak verilen uyarana P1 kortikali/itsel uyar.lm./ cevap kaydedilmi/tir. /da/ konu/ma hecesinin süresi 200 msn veuyaran.n tekrar say.s. 1.1/sn olarak ayarlanm./t.r. Konu/ma uyaran. bir hoparlör ilenormal i/itenlerin sa7 taraf.ndan, implantl.lar.n, implant.n oldu7u taraftan 45 derece aç.ile verilmi/tir. Verteks (Cz) noninverting elektrot, al.n (Fpz) toprak elektrot, M1/2 veyainion (Oz) inverting elektrot olarak belirlenmi/tir. Normal i/iten çocuklar.n ya/lar. veP1 komponentinin latans. aras.nda anlaml. bir korelasyon oldu7u, ya/ ilerledikçe P1latans de7erinde k.salma oldu7u saptanm./t.r. Koklear implantl. çocuklarda ya/ ile P1latans. aras.nda anlaml. bir ili/ki bulunmam./t.r. Ancak koklear implant kullan.m süresiartt.kça P1 latans.nda k.salma oldu7u belirlenmi/tir. Özellikle erken dönemde implanteedilmi/ çocuklar.n, k.sa süreli koklear implant kullan.c.s. olmalar.na ra7men normali/iten ya/.tlar.n.n latans de7erlerine daha h.zl. ula/t.klar. gözlenmi/tir. Elde edilenbulgular, i/itsel deprivasyon sonucu santral i/itsel sistemde dejenerasyonlar oldu7unu,erken dönemde koklear implant uygulamas.ndan sonra k.sa sürede P1 latans.n.n normali/iten çocuklar.nkine benzer sürede olu/tu7unu göstermi/tir.Anahtar Kelimeler: P1 latans/, koklear implant, santral i.itsel sistem

Abstract:
The goal of this study was to evaluate central auditory system maturation of thecochlear implanted children and also to determine whether there were similarities in P1latency between the early implanted children and normal hearing children . Ourmeasure of central auditory function was the latency of the P1 auditory evokedpotential, whose generators included auditory thalamocortical areas. 19 normal hearingchildren, ranging between 9 months - 7 years and 16 implanted children, rangingbetween 2-11 years were included . The implant age was between 1-7 years.There wereno neurological, language and otological problems in normal hearing children. Allimplanted children had congenital hearing loss and used their implants at least for 4months. /da/ speech stimuli, was used in measuring P1 latency. Repetition rate was1.1/sec and the duration of stimulus was 200 msec. The stimulus was given vialoudspeaker with 45 degree angle from the right side of the normal hearing children,and from the implanted side of the implanted children. Cz (Vertex) was non-invertingelectrode, Fpz (forehead) was ground electrode and mastoid of the nonimplanted side orOz (inion) were used for inverting electrode. A significant relationship was foundbetween the age of normal hearing children and P1 latency, as the age increased, P1latency decreased. There was no significant relationship between the age and the P1latency in the cochlear implanted children. But there was a relationship between theduration of the implantation and P1 latency, as the duration of implantation increasedP1 latency decreased. Our data suggest that the P1 latency showed similarities in thechildren received implant at an early age as normal hearing children.Key Words: P1 latency, cochlear implant, central auditory system.