Akut koroner sendrom nedeniyle perkütan koroner girişim yapılan hastalarda biyokimyasal parametreler ve epikardiyal yağ kalınlığı ile kontrast madde nefropatisi arasındaki ilişki
The relationship between epicardial adipose tissue and biochemical parameters with contrast induced nephropathy in patients with percutaneous coronary intervention due to acute coronary syndrome
Yazar: HÜSEYİN DURAK
Danışman: DOÇ. DR. TURAN ERDOĞAN
Recep Tayyip Erdoğan Üniversitesi / Tıp Fakültesi / Kardiyoloji Ana Bilim Dalı
Derece: Tıpta Uzmanlık, 2019
Konu: Kardiyoloji = Cardiology
Dizin: Akut böbrek hasarı = Acute kidney injury ; Akut koroner sendrom = Acute coronary syndrome ; Biyokimya = Biochemistry ; Böbrek = Kidney ; Cerrahi işlemler-minimal girişimsel = Surgical procedures-minimally invasive ; Epikardiyal yağ dokusu = Epicardial fat tissue ; Kontrast maddeler = Contrast media

Özet:
Aim: The aim of this study was to investigate whether there is a relationship
between contrast induced nephropathy (CIN) and epicardial adipose tissue (EAT)
in addition to biochemical parameters in patients undergoing coronary
angiography (CAG) and percutaneous coronary intervention (PCI) due to acute
coronary syndrome (ACS).
Methods: Patients who underwent PCI due to ACS between 01/02/2017 and
01/09/2017 were also examined cross-sectional and retrospectively. A total of 302
patients were included in the study. A possible relationship between CIN with
EAT, other echocardiographic parameters and biochemical parameters was
evaluated by statistical analysis.
Results: 61 of the patients developed CIN (age: 67.8 ± 12.8 years) and 241 of
them did not develop CIN (age: 61.5 ± 10.9). EAT, age, hypertension, aortic
sclerosis, HbA1c, uric acid, fibrinogen, DM, insulin use, smoking, Mehran score,
mitral annuler calcification and creatinine levels on admisson were found to be
related to CIN. Aortic sclerosis, uric acid and HbA1c were independent predictor
of the development of CIN.
Conclusions: In patients who underwent PCI due to ACS, an increase in the
amount of EAT was associated with the risk of developing CIN. Aortic sclerosis,
uric acid and HbA1c were independent risk factors for CIN.

Keywords: Acute coronary syndrome, epicardial adipose tissue, contrast induced
nephropathy

Abstract:
Aim: The aim of this study was to investigate whether there is a relationship
between contrast induced nephropathy (CIN) and epicardial adipose tissue (EAT)
in addition to biochemical parameters in patients undergoing coronary
angiography (CAG) and percutaneous coronary intervention (PCI) due to acute
coronary syndrome (ACS).
Methods: Patients who underwent PCI due to ACS between 01/02/2017 and
01/09/2017 were also examined cross-sectional and retrospectively. A total of 302
patients were included in the study. A possible relationship between CIN with
EAT, other echocardiographic parameters and biochemical parameters was
evaluated by statistical analysis.
Results: 61 of the patients developed CIN (age: 67.8 ± 12.8 years) and 241 of
them did not develop CIN (age: 61.5 ± 10.9). EAT, age, hypertension, aortic
sclerosis, HbA1c, uric acid, fibrinogen, DM, insulin use, smoking, Mehran score,
mitral annuler calcification and creatinine levels on admisson were found to be
related to CIN. Aortic sclerosis, uric acid and HbA1c were independent predictor
of the development of CIN.
Conclusions: In patients who underwent PCI due to ACS, an increase in the
amount of EAT was associated with the risk of developing CIN. Aortic sclerosis,
uric acid and HbA1c were independent risk factors for CIN.

Keywords: Acute coronary syndrome, epicardial adipose tissue, contrast induced
nephropathy.