protocolSection identificationModule nctId: NCT06377657, orgStudyIdInfo id: DONT4GET, briefTitle: Oxidative and Antioxidant Indices to HIIT and Aloe Vera Supplementation in Patients With T2DM, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-01-15, primaryCompletionDateStruct date: 2023-06-21, completionDateStruct date: 2024-02-19, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: University of Nis, class: OTHER, descriptionModule briefSummary: Diabetes is a prevalent metabolic disease that leads to increased blood sugar levels due to insulin shortage or resistance. Type 2 diabetes is often linked to obesity, which can increase insulin resistance. Meteorin-like protein (METRNL) is a new secreted protein that affects insulin sensitivity and has been found to be negatively related to serum glucose levels in people with diabetes.Oxidative stress in diabetics can stimulate the production of inflammatory mediators, increasing the activity of the antioxidant system. Aloe vera, a widely used plant, has been used for treating diabetes, wound healing, tumors, and inflammatory bowel disease. It has anti-inflammatory, antioxidant, neuroprotective, antidepressant, and memory-enhancing effects.Exercise can improve diabetic patients' conditions by increasing the expression of GLUT4 protein and skeletal muscle. High-intensity interval training has been shown to increase the expression of the METORIN gene in human subjects and decrease MDA in type 2 diabetic patients. However, no studies have examined the simultaneous effect of exercise and Aloe vera on diabetes indicators.The present study aims to investigate the response of METRNL and some oxidative and antioxidant plasma indicators to high-intensity interval training and Aloe vera supplementation in type 2 diabetic men. The findings indicate that exercise and consumption of plants with anti-inflammatory and antioxidant properties can be effective in modulating the pathological effects of diabetes and increasing insulin sensitivity., conditionsModule conditions: Diabetes Type 2, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: The participants were blinded for the supplementation., whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 44, type: ACTUAL, armsInterventionsModule interventions name: Exercise, interventions name: Aloe vera, outcomesModule primaryOutcomes measure: METRNL - Meteorin Like, Glial Cell Differentiation Regulator, secondaryOutcomes measure: Glutathione peroxidase (GPx), secondaryOutcomes measure: Serum superoxide dismutase (SOD), secondaryOutcomes measure: Total antioxidant blood capacity (TAD), secondaryOutcomes measure: Plasma malondialdehyde (MDA), eligibilityModule sex: MALE, minimumAge: 25 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule locations facility: Department of Sport Physiology, Faculty of Sport and Physical education, Islamic Azad University of Ayatollah Amoli, Amol, Iran, city: Amol, country: Iran, Islamic Republic of, geoPoint lat: 36.46961, lon: 52.35072, hasResults: False