protocolSection identificationModule nctId: NCT06367764, orgStudyIdInfo id: BPS-2022C3-30535, briefTitle: A Comparative Effectiveness Study of PTSD Treatments Among Sexual and Gender Minority Populations, acronym: LIFESCAPE, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2028-06, completionDateStruct date: 2028-06, studyFirstPostDateStruct date: 2024-04-16, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: University of California, San Francisco, class: OTHER, collaborators name: Patient-Centered Outcomes Research Institute, collaborators name: Stanford University, descriptionModule briefSummary: The goal of this clinical trial is see if Cognitive Processing Therapy and STAIR Narrative Therapy work to treat posttraumatic stress disorder (PTSD) among lesbian, gay, bisexual, transgender, queer/questioning, intersex, asexual/aromantic, and all other sexual or gender minority (LGBTQIA+) adults. The main questions it aims to answer are:* Do these treatments reduce PTSD symptoms in LGBTQIA+ patients?* Do these treatments help improve quality of life and reduce depression in LGBTQIA+ patients?* Do stress from stigma and discrimination and drug/alcohol use change the impact of the treatment on PTSD symptoms?* Are LGBTQIA+ patients satisfied with these treatments? Do these treatments work differently among different groups within the LGBTQIA+ community?* Do LGBTQIA+ patients complete these treatments?Study participants will receive one of these two PTSD treatments. Participants will complete assessments before and after receiving treatment., conditionsModule conditions: PTSD, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 400, type: ESTIMATED, armsInterventionsModule interventions name: Cognitive Processing Therapy, interventions name: STAIR Narrative Therapy, outcomesModule primaryOutcomes measure: Change in Posttraumatic Stress Disorder (PTSD) Symptoms Measured by PTSD Checklist for DSM-5 (PCL-5), secondaryOutcomes measure: Change in Depression Measured by Patient Health Questionnaire (PHQ-9), secondaryOutcomes measure: Change in Quality of Life Measured by WHOQOL-BREF: Social Relationships and Environment Scales, secondaryOutcomes measure: Patient Satisfaction Measured By Satisfaction with Therapy and Therapist Scale-Revised (STTS-R), secondaryOutcomes measure: Assessing Treatment Dropout Measured by Completion of Less than 8 Sessions, otherOutcomes measure: Minority Stress Measured by Cultural Assessment of Risk for Suicide (CARS) Minority Stress Subscale - Moderator, otherOutcomes measure: Substance Use Measured Alcohol and Substance, Smoking, and Substance Involvement Screening Test (ASSIST) - Moderator, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: UCSF Alliance Health Project, city: San Francisco, state: California, zip: 94103, country: United States, contacts name: Annesa Flentje, PhD, role: CONTACT, geoPoint lat: 37.77493, lon: -122.41942, hasResults: False