protocolSection identificationModule nctId: NCT06305533, orgStudyIdInfo id: 854623, briefTitle: Efficacy of Photodynamic Therapy and LASER Disinfection in Periodontal Therapy for Treatment of Periodontitis, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2024-09, completionDateStruct date: 2024-10, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: University of Baghdad, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to Investigate the clinical and microbiological efficacies of Laser disinfection and ICG-mediated aPDT as adjunct to RSD for patients with periodontitis. The main question it aims to answer is:Does the use of laser disinfection or ICG-mediated aPDT as adjunct to RSD are effective in improving clinical parameters and reducing the load of periodontal pathogens.Participants will undergo full-mouth supragingival debridement by using ultrasonic device at baseline.All patients will be instructed to brush their teeth twice daily and will be supplied with the same type of tooth paste and toothbrush, with suitable interdental aids.All the patients will be instructed to attend again after 7 days. One week later, sites randomly allocated to control (Ctrl) group and test groups which will receive, in addition to RSD, either aPDT or periodontal pocket disinfection (Biolase). For all groups, sites with initial PPD 4-6 mm will be treated with RSD using area specific (Graecy) curettes., conditionsModule conditions: Periodontitis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: This study is 3 arm, split-mouth, double blinded, randomized clinical trial. The first group will receive RSD only, the second group will be treated with RSD + aPDT with ICG as a PS, and the last group will receive RSD + Laser disinfection., primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: Sites will randomly be assigned to test or control groups according to a computer-generated list. Allocation concealment will be assured by opaque, sealed envelopes prepared and sequentially numbered by a person not otherwise involved in the study. The person responsible for delivering treatment will be aware about allocation of the groups, while the assessor will be blinded., whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 18, type: ESTIMATED, armsInterventionsModule interventions name: LASER disinfection, interventions name: Photodynamic therapy, interventions name: Root surface debridement, outcomesModule primaryOutcomes measure: Probing Pocket Depth (PPD), secondaryOutcomes measure: Bleeding on probing (BOP), secondaryOutcomes measure: Plaque index (PI), secondaryOutcomes measure: Clinical attachment loss (CAL), secondaryOutcomes measure: Change in bacterial load of F. nucleatum and Fretibacterium fastidiosum, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: College of Dentistry, University of Baghdad, status: RECRUITING, city: Baghdad, zip: 10047, country: Iraq, contacts role: CONTACT, phone: +964 14169394, email: master@codental.uobaghdad.edu.iq, geoPoint lat: 33.34058, lon: 44.40088, hasResults: False