protocolSection identificationModule nctId: NCT06282718, orgStudyIdInfo id: POS-ARI-PC CORE and AUDIT, secondaryIdInfos id: 965313, type: OTHER_GRANT, domain: European Union, secondaryIdInfos id: 10204126, type: REGISTRY, domain: ISRCTN, secondaryIdInfos id: 55487, type: OTHER, domain: NIHR CPMS, secondaryIdInfos id: 324504, type: OTHER, domain: IRAS, briefTitle: A Long-term Observational Study Evaluating the Presentation and Management of Acute Respiratory Tract Infections in Primary Care Across Europe, acronym: POS-ARI-PC, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-02, primaryCompletionDateStruct date: 2026-03, completionDateStruct date: 2026-03, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: European Clinical Research Alliance for Infectious Diseases (ECRAID), class: OTHER, collaborators name: UMC Utrecht, collaborators name: University of Oxford, collaborators name: Universiteit Antwerpen, descriptionModule briefSummary: Acute respiratory infection (ARI) is the commonest reason for consulting in community care. Furthermore, new and re-emerging pathogens are often first noticed in primary care (PC). The POS-ARI-PC study is a long-term study, with the aim of describing the nature of ARI in adults and children presenting to PC across Europe. The POS-ARI-PC study will provide critically important data on the presentation and management of ARI, and build a research-ready infrastructure for studies related to the treatment, diagnosis, and prevention of ARI in primary care settings. Additional observational studies will be embedded and use the infrastructure developed in POS-ARI-PC., conditionsModule conditions: Acute Respiratory Tract Infection, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 2000, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Age Bands, primaryOutcomes measure: The proportion with a preliminary diagnosis of various sub-categories of ARI (e.g. LRTI, URTI), primaryOutcomes measure: Overall illness severity rating, primaryOutcomes measure: Swab samples taken and retrospective viral/microbiological infection analysis performed (multiplex PCR) to identify potential causative pathogens., primaryOutcomes measure: Proportion undergoing POC (with results) and lab-based investigations, primaryOutcomes measure: Details of prescriptions given on presentation of ARI, primaryOutcomes measure: Details of tests ordered on presentation of ARI, primaryOutcomes measure: Return to usual daily activities, primaryOutcomes measure: Feeling recovered from RTI, primaryOutcomes measure: Use of prescription medication, primaryOutcomes measure: Use of over the counter medications, primaryOutcomes measure: Complications reported associated to ARI presentation, primaryOutcomes measure: Variation in practice and advice from national guidelines, to be fed back to national teams, secondaryOutcomes measure: Recommendations on how to improve study processes, recruitment and study communication based on shared understanding and insights from researchers, clinicians, and patients., secondaryOutcomes measure: An understanding of the meaning of study results for European primary care, from the perspectives of clinicians and patients, and recommendations regarding the implementation of findings., secondaryOutcomes measure: An understanding of changing health-seeking behaviour, management and expectations to inform clinical studies and trials, secondaryOutcomes measure: Approval for a study-specific appendix (SSA) or an intervention-specific appendix (ISA) of an embedded (non) randomised study for ARI in primary care associated with this POS, measured using the number of embedded studies to this POS-ARI-PC platform over, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False