protocolSection identificationModule nctId: NCT06375213, orgStudyIdInfo id: 425/66, briefTitle: Investigating Neurocognitive Disorders Epidemiology, acronym: INDE, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-08-24, primaryCompletionDateStruct date: 2035-08-24, completionDateStruct date: 2035-08-24, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: King Chulalongkorn Memorial Hospital, class: OTHER, collaborators name: Health Systems Research Institute,Thailand, descriptionModule briefSummary: This is a prospective cohort study with the main purpose of predicting progression neurocognitive disorders in Thai population. The main predictor variables to be evaluated are plasma phosphorylated tau (p-tau) level and cognitive test scores, which will be combined using statistical/computational modeling. Additionally, it seeks to evaluate biomarkers for diagnosing disease pathologies, understand their correlation with clinical outcomes, and explore the socioeconomic impact of neurocognitive disorders. The study invites both participants for biospecimen collection, structured interviews, and cognitive examinations and schedules follow-up visits annually or biennially., conditionsModule conditions: Dementia, conditions: Cognitive Decline, conditions: Alzheimer Disease, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 990, type: ESTIMATED, armsInterventionsModule interventions name: Plasma tau phosphorylated at Thr217, interventions name: Neurocognitive examination, outcomesModule primaryOutcomes measure: Progression to dementia, primaryOutcomes measure: Changes in Sum of Boxes of the Clinical Dementia Rating Scale, secondaryOutcomes measure: Changes in the Montreal Cognitive Assessment, secondaryOutcomes measure: Changes in the Montreal Cognitive Assessment - Memory Index Score, secondaryOutcomes measure: Changes in the Mini Mental State Examination, secondaryOutcomes measure: Changes in the Wechsler Memory Scale - Fourth Edition (WMS-IV) Visual Reproduction Scaled Score, secondaryOutcomes measure: Changes in the Wechsler Memory Scale - Fourth Edition (WMS-IV) Logical Memory Scaled Score, secondaryOutcomes measure: Changes in the Wechsler Memory Scale - Fourth Edition (WMS-IV) Verbal Paired Associates Scaled Score, secondaryOutcomes measure: Biological diagnosis of Alzheimer's disease, secondaryOutcomes measure: Biological staging of Alzheimer's disease, secondaryOutcomes measure: Quantitative amyloid PET uptake., secondaryOutcomes measure: Quantitative tau PET uptake in various cortical regions., secondaryOutcomes measure: Future diagnosis of Alzheimer's disease dementia., otherOutcomes measure: Quality of life (WHOQOL-BREF), otherOutcomes measure: Quality of life (EQ-5D-5L), otherOutcomes measure: Number of modifiable risk factors, eligibilityModule sex: ALL, minimumAge: 35 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: King Chulalongkorn Memorial Hospital, status: RECRUITING, city: Pathum Wan, state: Bangkok, zip: 10330, country: Thailand, contacts name: Adipa Chongsuksantikul, D.Eng., role: CONTACT, phone: +66 (0)84 1134443, email: adipar@gmail.com, geoPoint lat: 13.73649, lon: 100.5239, hasResults: False