protocolSection identificationModule nctId: NCT06353594, orgStudyIdInfo id: COPERNICAN TRIAL, briefTitle: Reduced Stent Strategy Versus Conventional Percutaneous Coronary Revascularization in Patients Presenting With STEMI, acronym: COPERNICAN, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-11, primaryCompletionDateStruct date: 2026-09, completionDateStruct date: 2035-09, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Jorge Sanz Sanchez, class: OTHER, descriptionModule briefSummary: The objective is to compare a reduced stent strategy based on drug-coated balloon (DCB) percutaneous coronary intervention (PCI) with conventional drug-eluting stent (DES) coronary revascularization in patients presenting with ST-segment myocardial infarction (STEMI).Randomization will be performed after successful culprit-lesion guidewire crossing and flow restoration. Random allocation in a 1:1 fashion to one of the following strategies:* Study group: reduced stent PCI strategy (DCB-based)* Control group: conventional PCI strategy (DES-based)., conditionsModule conditions: ST Elevation Myocardial Infarction, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 1272, type: ESTIMATED, armsInterventionsModule interventions name: Primary PCI, outcomesModule primaryOutcomes measure: Target lesion failure (TLF), secondaryOutcomes measure: Incidence of all-cause death, secondaryOutcomes measure: Incidence of myocardial infarction, secondaryOutcomes measure: Incidence of cardiovascular death, secondaryOutcomes measure: Incidence of target lesion revascularization, secondaryOutcomes measure: Incidence of stent thrombosis, secondaryOutcomes measure: Incidence of acute vessel closure, secondaryOutcomes measure: Incidence of stroke, secondaryOutcomes measure: Incidence of acute kidney injury, secondaryOutcomes measure: Incidence of bleeding, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hospital Universitario Y Politecnico La Fe, status: RECRUITING, city: Valencia, state: Comunidad Valenciana, country: Spain, contacts name: Jorge Sanz Sánchez, PI, role: CONTACT, geoPoint lat: 39.46975, lon: -0.37739, locations facility: Consorcio Hospitalario Provincial de Castellon, status: NOT_YET_RECRUITING, city: Castelló, country: Spain, contacts name: David Tejada Ponce, PI, role: CONTACT, geoPoint lat: 41.01149, lon: 0.84856, locations facility: Hospital General Universitario de Elche, status: NOT_YET_RECRUITING, city: Elche, country: Spain, contacts name: Paula Tejedor Viñuela, PI, role: CONTACT, geoPoint lat: 38.26218, lon: -0.70107, locations facility: Hospital Universitari de Bellvitge, status: NOT_YET_RECRUITING, city: Hospitalet de Llobregat, country: Spain, contacts name: Neus Salvatella Giralt, PI, role: CONTACT, geoPoint lat: 41.35967, lon: 2.10028, locations facility: Hospital Universitario 12 de Octubre, status: NOT_YET_RECRUITING, city: Madrid, country: Spain, contacts name: Fernando Sarnago Cebada, PI, role: CONTACT, geoPoint lat: 40.4165, lon: -3.70256, locations facility: Hospital Universitario de La Princesa, status: NOT_YET_RECRUITING, city: Madrid, country: Spain, contacts name: Fernando Rivero Crespo, PI, role: CONTACT, geoPoint lat: 40.4165, lon: -3.70256, locations facility: Hospital Universitario Puerta de Hierro Majadahonda, status: NOT_YET_RECRUITING, city: Madrid, country: Spain, contacts name: Juan F Oteo Domínguez, PI, role: CONTACT, geoPoint lat: 40.4165, lon: -3.70256, locations facility: Hospital Universitario Regional de Malaga, status: NOT_YET_RECRUITING, city: Málaga, country: Spain, contacts name: Cristobal Urbano Carrillo, PI, role: CONTACT, geoPoint lat: 36.72016, lon: -4.42034, locations facility: Hospital Universitario de Navarra, status: NOT_YET_RECRUITING, city: Pamplona, country: Spain, contacts name: Guillermo Sánchez Elvira, PI, role: CONTACT, geoPoint lat: 42.81687, lon: -1.64323, locations facility: Hospital Universitario Virgen Del Rocio, status: NOT_YET_RECRUITING, city: Sevilla, country: Spain, contacts name: José Díaz Fernández, PI, role: CONTACT, geoPoint lat: 37.38283, lon: -5.97317, locations facility: Hospital Universitari Joan Xxiii de Tarragona, status: NOT_YET_RECRUITING, city: Tarragona, country: Spain, contacts name: Mauricio Torres Sánchez, PI, role: CONTACT, geoPoint lat: 41.11667, lon: 1.25, locations facility: Consorcio Hospital General Universitario de Valencia, status: RECRUITING, city: Valencia, country: Spain, contacts name: Eva Rumiz González, PI, role: CONTACT, geoPoint lat: 39.46975, lon: -0.37739, locations facility: Hospital Clinico Universitario de Valladolid, status: NOT_YET_RECRUITING, city: Valladolid, country: Spain, contacts name: Ignacio J Amat Santos, PI, role: CONTACT, geoPoint lat: 41.65518, lon: -4.72372, locations facility: Hospital Clinico Universitario Lozano Blesa, status: NOT_YET_RECRUITING, city: Zaragoza, country: Spain, contacts name: Antonela Lukic Otanovic, PI, role: CONTACT, geoPoint lat: 41.65606, lon: -0.87734, locations facility: Hospital Universitario Miguel Servet, status: NOT_YET_RECRUITING, city: Zaragoza, country: Spain, contacts name: Georgina A Fuertes Ferre, role: CONTACT, geoPoint lat: 41.65606, lon: -0.87734, hasResults: False