hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06378489, orgStudyIdInfo id: 2022-0346-01, briefTitle: The Use of Etonogestrel Contraceptive Implant as Treatment for Endometrial Hyperplasia Without Atypia: A Cohort Study, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-01, primaryCompletionDateStruct date: 2025-01-31, completionDateStruct date: 2025-05-31, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: University of the Philippines, class: OTHER, collaborators name: Organon, descriptionModule briefSummary: Endometrial hyperplasia without atypia is a condition in which the endometrium (the lining of the uterus) becomes abnormally thick. Although endometrial hyperplasia without atypia is not cancer, it can lead to endometrial cancer in 1-3% of women. This disease is treated by giving progestins. The optimal route, dosage and duration of progestin treatment for endometrial hyperplasia has not yet been determined until now. However, several publications have suggested the use of levonorgestrel releasing IUD as first-line treatment for endometrial hyperplasia without atypia. The other common medications used are the oral progestins medroxyprogesterone (MPA) and norethisterone acetate (NETA).The etonogestrel implant (Implant NXT) has been approved for contraceptive use by the US FDA in 2006. The mchanism of action of the implant for contraception suggests a potential application for its use in the treatment on hyperplasia. Off-label use of the implant for adrnomyosis, endometriosis and chronic pelvic pain has already been described in various studies. However, its therapeutic effect on endometrial hyperplasia without atypia has not been studied yet. The researchers propose to use the etonogestrel implant (Implant NXT) as novel treatment for endometrial hyperplasia without atypia. The study aims to determine the rate of regression to normal endometrium among patients with endometrial hyperplasia without atypia at 3 and 6 months after insertion of the implant., conditionsModule conditions: Endometrial Hyperplasia Without Atypia, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Etonogestrel implant, outcomesModule primaryOutcomes measure: Rate of (resolution) regression to normal endometrium, primaryOutcomes measure: Endometrial thickness (by ultrasound), eligibilityModule sex: FEMALE, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06378450, orgStudyIdInfo id: 2022-23892-31512-2, briefTitle: Dose-Response Effects of Mindfulness Meditation, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-22, primaryCompletionDateStruct date: 2024-11-30, completionDateStruct date: 2024-11-30, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-24, sponsorCollaboratorsModule leadSponsor name: University of Melbourne, class: OTHER, descriptionModule briefSummary: The goal of this randomized controlled trial is to test for evidence of dose-response effects in a sample of healthy adults with little to no prior experience with meditation.The main question it aims to answer is whether larger doses of mindfulness meditation yield greater positive changes in wellbeing than smaller doses.Our hypotheses are that (1) larger doses of mindfulness training will yield significantly larger effects, and (2) different doses will be significantly associated with variation in participant engagement, with lower engagement associated with higher doses.Researchers will compare each of three dose conditions, 10-min, 20-min, 30-min, against a minimal dose condition of 3-4 min.Participants will take a 28-day mindfulness meditation course, with guided audio instructions provided daily throughout the intervention period (excluding one rest day per week). They will also be asked to respond to surveys before, during, and after the intervention., conditionsModule conditions: Well-Being, Psychological, conditions: Depression, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 860, type: ESTIMATED, armsInterventionsModule interventions name: Mindfulness meditation guided practice, outcomesModule primaryOutcomes measure: Psychological wellbeing, secondaryOutcomes measure: Psychological Distress, secondaryOutcomes measure: Anxiety, secondaryOutcomes measure: Depression, secondaryOutcomes measure: Nonattachment, secondaryOutcomes measure: Trait Mindfulness, secondaryOutcomes measure: Decentering, secondaryOutcomes measure: Equanimity, secondaryOutcomes measure: Repetitive Negative Thoughts, secondaryOutcomes measure: Emotional Regulation, secondaryOutcomes measure: Attentional Control, secondaryOutcomes measure: Emotional Reactivity, secondaryOutcomes measure: Social Anxiety, secondaryOutcomes measure: Sleep Quality, otherOutcomes measure: Momentary Mood, otherOutcomes measure: State Mindfulness, otherOutcomes measure: Attention, otherOutcomes measure: Decentering, otherOutcomes measure: Mindful Attitudes, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06378424, orgStudyIdInfo id: 2023-6/6, briefTitle: The Effectiveness of Local Dry Cold, Hot and Vibration Applications in Peripheral Intravenous Catheterization, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-03-22, primaryCompletionDateStruct date: 2023-03-22, completionDateStruct date: 2023-08-23, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: Uludag University, class: OTHER, descriptionModule briefSummary: Aim: The aim of the present study was to examine the effect on venous dilation, procedure duration and pain severity of local hot, cold and vibration applications performed on the intervention area before peripheral intravenous catheterization in adults.Methods: The study included 120 adults who were randomly selected between March and August 2023. One application group (n=30) received local hot application, one group (n=30) received local cold application, and one (n=30) received local vibration using the Buzzy® device. The applications, to the site of the peripheral intravenous catheterization, lasted one minute. The control group (n=30) the received standard peripheral intravenous catheterization application. The groups' venous dilation was assessed on the vein assessment scale and the level of pain felt during catheterization was assessed using a visual analog scale., conditionsModule conditions: Pain Management, conditions: Emergency Unit, conditions: Diarrhea, conditions: Nausea, conditions: Vomiting, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 120, type: ACTUAL, armsInterventionsModule interventions name: Cold Application, interventions name: Heat Application, interventions name: Vibration Application, outcomesModule primaryOutcomes measure: pain intensity in mm, primaryOutcomes measure: venous dilation in score, primaryOutcomes measure: procedure duration in sec, secondaryOutcomes measure: weight, secondaryOutcomes measure: height, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Bursa Uludag University Hospital, city: Bursa, state: Nilüfer, country: Turkey, geoPoint lat: 40.19559, lon: 29.06013, hasResults: False
protocolSection identificationModule nctId: NCT06378411, orgStudyIdInfo id: P109, briefTitle: Development and Application of a Musical Game for Motor Rehabilitation, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-04, primaryCompletionDateStruct date: 2024-07, completionDateStruct date: 2024-10, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: Universidade da Madeira, class: OTHER, descriptionModule briefSummary: The aim of this study is to develop, adapt a musical game for residents of RAM, and evaluated the usability and correlation between this game with the improvement of motor coordination in short time., conditionsModule conditions: Health People, conditions: Survivors of Stroke, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 45, type: ESTIMATED, armsInterventionsModule interventions name: Music Game Intervention, outcomesModule primaryOutcomes measure: Motor Coordination, primaryOutcomes measure: Usability, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Universidade da Madeira, status: RECRUITING, city: Funchal, country: Portugal, contacts name: Yasmim Moniz, Master, role: CONTACT, phone: +351 968412551, email: yasmimfernandes08@hotmail.com, contacts role: CONTACT, email: yasmimfernandes08@hotmail.com, geoPoint lat: 32.66568, lon: -16.92547, hasResults: False
protocolSection identificationModule nctId: NCT06378385, orgStudyIdInfo id: DevelopmentCEOAS, briefTitle: Development and Content Validation of the Childhood Early Oral Aging Syndrome (CEOAS) Index for the Deciduous Dentition, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2024-10-31, completionDateStruct date: 2024-12-20, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: University of Nove de Julho, class: OTHER, descriptionModule briefSummary: Premature, non-physiological tooth wear in childhood has numerous repercussions for oral health. This is a growing problem with multifactorial causes and associated with the current lifestyle. The aim of the present study was the development and determination of content validity of the Childhood Early Oral Aging Syndrome (CEOAS) index for the primary dentition as a diagnostic and epidemiological survey tool considering the current changes found in this population., conditionsModule conditions: Aging, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: RETROSPECTIVE, enrollmentInfo count: 6, type: ESTIMATED, armsInterventionsModule interventions name: Childhood Early Oral Aging Syndrome index, outcomesModule primaryOutcomes measure: Development of CEOAS index, secondaryOutcomes measure: Validation of CEOAS index, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Universidade Metropolitana de Santos - UNIMES, city: Santos, state: São Paulo, zip: 11045-002, country: Brazil, geoPoint lat: -23.96083, lon: -46.33361, hasResults: False
protocolSection identificationModule nctId: NCT06378372, orgStudyIdInfo id: ETICA-ULE-064-2023, briefTitle: How Does Pianistic Musical Training Influence the Development of Alzheimer's Disease?, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-01, primaryCompletionDateStruct date: 2024-08-01, completionDateStruct date: 2025-06-01, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: David Franco Castellanos, class: OTHER, collaborators name: Jesús Ángel Seco Calvo, collaborators name: Javier Tejada Garcia, descriptionModule briefSummary: The goal of this clinical trial is to learn about and describe how pianistic training influences the development of Alzheimer's disease.The key question is: Can pianistic practice influence the development of Alzheimer's disease?Participants will receive piano lessons for 4 weeks (20 sessions) and we will evaluate the evolution of the different parameters described by the tests carried out., conditionsModule conditions: Dementia of Alzheimer Type, conditions: Dementia, conditions: Dementia, Vascular, conditions: Dementia, Mixed, conditions: Dementia Frontal, conditions: Dementia With Lewy Bodies, conditions: Cognitive Decline, conditions: Neurologic Disorder, conditions: Neurologic Dysfunction, conditions: Neurologic Deficits, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: An intervention based on teaching the piano in an individualized way, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Music therapy based on piano learning, outcomesModule primaryOutcomes measure: State of global deterioration, primaryOutcomes measure: Minimental Test, primaryOutcomes measure: RDRS-2 Rapid Disability Assessment Scale, primaryOutcomes measure: MONTREAL COGNITIVE ASSESSMENT (MOCA), primaryOutcomes measure: WAIS-IV, primaryOutcomes measure: Behavioral disorders: BEHAVE-AD, primaryOutcomes measure: NPI - CUMMINGS, primaryOutcomes measure: Evaluation of the caregiver's burden (Zarit test), eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Universidad de León, city: León, state: Castilla Y León, zip: 24004, country: Spain, geoPoint lat: 42.60003, lon: -5.57032, hasResults: False
protocolSection identificationModule nctId: NCT06378359, orgStudyIdInfo id: IDIM-2023-32364, briefTitle: Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-29, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: University of Minnesota, class: OTHER, descriptionModule briefSummary: The purpose of the study is to determine the effectiveness, safety, and health-care utilization and costs of a preoperative Staphylococcus aureus (SA) screening and decolonization bundle, (5 days of nasal mupirocin ointment, chlorhexidine gluconate (CHG) body wash, and CHG mouth rinse), in eradicating SA carriage compared to other SA decolonization approaches. The study will conduct a single center pilot trial to compare efficacy of different SA decolonization approaches in pre-surgical patients, in eradicating SA carriage, after obtaining informed consent.The study will compare four different approaches, Arm 1) screen for SA carriage and using the three-drug decolonization bundle for 5 days among patients with SA colonization, non SA carriers in this arm will get two pre-op showers with CHG soap, Arm 2) all participants receive the three drug decolonization bundle, Arm 3) all receive pre-op nasal povidone iodine the day of surgery plus two pre-op showers with CHG soap, and Arm 4) all receive nasal alcohol gel the day of surgery plus two pre op showers with CHG soap.The primary efficacy outcome will be eradication of SA colonization at all 5 body sites. Secondary outcomes will be SA surgical site infections (SSIs), all SSIs, and SA healthcare associated infections (HAIs). The study will also compare eradication of SA from each of the 5 body sites as a secondary outcome., conditionsModule conditions: Staphylococcus Aureus Colonization, conditions: Surgical Site Infections, conditions: Healthcare Associated Infections, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 250, type: ESTIMATED, armsInterventionsModule interventions name: Screening and decolonization for SA carriers with the 3 drug bundle, interventions name: No screening for SA, interventions name: no screening, interventions name: Nasal povidone-iodine on surgery day plus 2 CHG pre-op showers without screening., interventions name: Nasal alcohol gel on surgery day plus 2 CHG pre-op showers without screening, outcomesModule primaryOutcomes measure: Efficacy in eradicating Staphylococcus aureus (SA), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Minnesota Medical Center and Clinics, status: RECRUITING, city: Minneapolis, state: Minnesota, zip: 55414, country: United States, contacts name: Pragya Karki, MD, role: CONTACT, phone: 612-301-6316, email: pkarki@umn.edu, geoPoint lat: 44.97997, lon: -93.26384, hasResults: False
protocolSection identificationModule nctId: NCT06378333, orgStudyIdInfo id: 2024-01-023, briefTitle: Incidence, Clinical Characteristics and Outcomes of Unstable Angina in the contempoRary Area., acronym: ICAR, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-11-27, primaryCompletionDateStruct date: 2024-01-27, completionDateStruct date: 2024-04-15, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: University Hospital, Montpellier, class: OTHER, descriptionModule briefSummary: The study aims to evaluate clinical characteristics and prognostic of a contemporary population of patients with UA defined using T hs-cTn measurements The study includes all patients admitted in 2 French university centers with the confirmed diagnostic of UA defined with clinical ischemic symptoms and T hs-cTn concentrations \< 99 percentile (undetectable: \<5ng/l or non-elevated: \<14ng/l), or ≥ 99 percentile but mildly elevated (14-50ng/l) .The primary end-point included major events at 1-year follow-up (total mortality, new ACS, hospitalization for cardiac causes)., conditionsModule conditions: Unstable Angina, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 210, type: ACTUAL, armsInterventionsModule interventions name: patients who underwent coronary angiography, outcomesModule primaryOutcomes measure: Hospitalisation for of unstable Angina, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 99 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University Hospital of Montpellier, city: Montpellier, zip: 34295, country: France, geoPoint lat: 43.61092, lon: 3.87723, hasResults: False
protocolSection identificationModule nctId: NCT06378307, orgStudyIdInfo id: CHUBX2022-06, briefTitle: A Transferability Study on the Conditions for a Successful Inclusive Education, acronym: TIAP, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-30, primaryCompletionDateStruct date: 2025-06-30, completionDateStruct date: 2025-06-30, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: University Hospital, Bordeaux, class: OTHER, descriptionModule briefSummary: The investigators are conducting a realist evaluation study with a multi-case and qualitative design. The study aims to identify the conditions that promote successful students with disabilities inclusive education at school. This study is nested in the TIAP research (Research to explore the conditions transfer of innovations in the field of disability, with a view to developing a transfer framework)., conditionsModule conditions: Inclusive Education, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: PROSPECTIVE, enrollmentInfo count: 114, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Effect of inclusive education on children with disabilities autonomy and social participation at school, primaryOutcomes measure: Effect of inclusive education on children with disabilities autonomy and social participation in their proximal living environment (leisures participation), primaryOutcomes measure: Effect of inclusive education on social participation of families with children with disabilities, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06378281, orgStudyIdInfo id: CRSK-3_221381, briefTitle: Testing a New Method to Improve Informed Consent in Prison Research, acronym: Spark BATIR, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-04-30, completionDateStruct date: 2025-09-30, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-24, sponsorCollaboratorsModule leadSponsor name: Stéphanie Baggio, class: OTHER, collaborators name: University of Bern, collaborators name: Leiden University, collaborators name: School of Health Sciences Fribourg, collaborators name: University Hospital, Geneva, descriptionModule briefSummary: Understanding of informed consent is often limited in prison, due to unique challenges faced by detained people. This study will test a modified "teach-to-goal" informed consent process compared to standard procedures. Conducted within a larger study on psychiatric outcomes, it aims to enhance ethical practices for vulnerable populations., conditionsModule conditions: ADHD, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Modified teach-to-goal informed consent, outcomesModule primaryOutcomes measure: Understanding of the informed consent (binary), secondaryOutcomes measure: Understanding of the informed consent (continuous), secondaryOutcomes measure: Evaluation of the informed consent, eligibilityModule sex: MALE, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Geneva University Hospitals, city: Geneva, zip: 1211, country: Switzerland, contacts name: Stéphanie Baggio, Prof., role: CONTACT, phone: +41316846774, email: stephanie.baggio@unibe.ch, geoPoint lat: 46.20222, lon: 6.14569, hasResults: False