protocolSection identificationModule nctId: NCT06367205, orgStudyIdInfo id: LY2023-135-A, briefTitle: Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2026-04-30, completionDateStruct date: 2026-06-30, studyFirstPostDateStruct date: 2024-04-16, lastUpdatePostDateStruct date: 2024-04-16, sponsorCollaboratorsModule leadSponsor name: RenJi Hospital, class: OTHER, descriptionModule briefSummary: Delayed graft function (DGF), delineated by the necessity for dialytic intervention within the initial week post-transplantation, afflicts approximately 20%-50% of recipients. The primary objective of this study is to investigate the potential efficacy of norepinephrine infusion in conjunction with goal-directed fluid therapy (GDFT) in mitigating the occurrence of DGF among individuals undergoing kidney transplantations. The findings of this investigation have the potential to advance the field of perioperative care in kidney transplantations by providing insights into optimized management strategies., conditionsModule conditions: Delayed Graft Function, conditions: End Stage Renal Disease, conditions: Kidney Transplantation, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 380, type: ESTIMATED, armsInterventionsModule interventions name: Goal-Directed Fluid Therapy (GDFT), interventions name: Regular Fluid Therapy, outcomesModule primaryOutcomes measure: The incidence of delayed graft function (DGF), secondaryOutcomes measure: The area under the curve of serum creatinine levels from postoperative day 1 to 7, secondaryOutcomes measure: Duration of DGF, secondaryOutcomes measure: Number of dialysis sessions during postoperative hospitalization, secondaryOutcomes measure: Total urine output on the second postoperative day, secondaryOutcomes measure: Duration of intensive care unit (ICU) stay, secondaryOutcomes measure: Length of hospitalization, secondaryOutcomes measure: Incidence of readmission within 30 days post-discharge, otherOutcomes measure: The incidence of acute rejection during hospitalization, otherOutcomes measure: The survival rates of transplanted kidneys at the one-year postoperative mark, otherOutcomes measure: The survival rates of transplanted patients at the one-year postoperative mark, otherOutcomes measure: The occurrence of adverse events (AEs), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: the First Affiliated Hospital of Zhengzhou University, status: NOT_YET_RECRUITING, city: Zhengzhou, state: Henan, zip: 450052, country: China, contacts name: Jianjun Yang, Dr., role: CONTACT, geoPoint lat: 34.75778, lon: 113.64861, locations facility: General Hospital of Northern Theatre Command, status: NOT_YET_RECRUITING, city: Shenyang, state: Liaoning, zip: 110016, country: China, contacts name: Yugang Diao, Dr., role: CONTACT, geoPoint lat: 41.79222, lon: 123.43278, locations facility: Renji Hospital, status: RECRUITING, city: Shanghai, state: Shanghai, zip: 200127, country: China, contacts name: Muyan Shi, B.S., role: CONTACT, phone: +862168383702, email: jsqdsmy@163.com, geoPoint lat: 31.22222, lon: 121.45806, hasResults: False