hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06379620, orgStudyIdInfo id: 22-5544, briefTitle: Pilot Open Label Use of the Hi-OXSR for the Treatment of Post COVID-19 Cognitive Dysfunction, acronym: Hi-OXSR, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-11-29, primaryCompletionDateStruct date: 2024-03-04, completionDateStruct date: 2024-03-04, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: University Health Network, Toronto, class: OTHER, descriptionModule briefSummary: During the worldwide COVID-19 pandemic a large number patients reported different functional complaints one month or later after recovery from the acute infection. This entity had a number of names including "long-COVID" or "post COVID condition". Long-COVID is on the rise and no effective treatment exists yet to improve cognitive function. Recent research has shown that people with even mild COVID had a greater decline in executive function, notably in their ability to perform complex tasks. What drives post-COVID cognitive changes is still a mystery and there are no effective treatments available. One hypothesis is that there is persistent immune activation resulting in reduction in cerebral blood flow. There is evidence that increased CO2 may decrease inflammation, and decreased CO2 may increase inflammation.Objectives: The primary objective of this pilot study is to assess the safety and tolerability of the use of Hi-OX sequential rebreathing for the treatment of post-COVID cognitive dysfunction. The secondary objective is to identify the effects of the use of the Hi-OX rebreathing treatment in changing post-COVID cognitive dysfunction., conditionsModule conditions: Post COVID-19 Condition, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: This is an open label, pilot treatment study. Screening data will be reviewed to determine subject eligibility. Upon successful completion of all screening procedures, subject will be considered eligible for enrollment.The subject will self-administer oxygen gas at 1to 3LPM via a Hi-OxSR Sequential Rebreathing mask, twice a day for 30 minutes with ventilation supplemented by the subject's rebreathed exhaled air. Total treatment is for 14 days. Subjects will be asked to return to the clinic for additional evaluations on Days 15 and 45., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 37, type: ACTUAL, armsInterventionsModule interventions name: Hi-OxSR Sequential Rebreathing mask (oxygen concentrator), outcomesModule primaryOutcomes measure: Safety of use of Hi-OX sequential rebreathing device, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University Health Network, city: Toronto, state: Ontario, zip: M5G 2C4, country: Canada, geoPoint lat: 43.70011, lon: -79.4163, hasResults: False
protocolSection identificationModule nctId: NCT06379607, orgStudyIdInfo id: HFNC2024, briefTitle: High Flow Nasal Cannula Rates in Pediatric Asthma, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-10-01, primaryCompletionDateStruct date: 2025-09-30, completionDateStruct date: 2025-09-30, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: University of Rochester, class: OTHER, descriptionModule briefSummary: This is a randomized, open-label, 3-armed feasibility trial will examine conventional oxygen therapy (COT) vs high flow nasal cannula at 4L/min flow vs HFNC at 2L/kg/min flow (max 60L/min) in moderate to severe pediatric asthma exacerbations., conditionsModule conditions: Pediatric Asthma, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 27, type: ESTIMATED, armsInterventionsModule interventions name: "High Flow" High Flow Nasal Cannula, interventions name: "Low Flow" High Flow Nasal Cannula, outcomesModule primaryOutcomes measure: Percent of participants enrolled, secondaryOutcomes measure: Mean Change in Pediatric Asthma Severity Score (PASS), secondaryOutcomes measure: Mean Change in Respiratory Rate, secondaryOutcomes measure: Mean Total Duration of Continuous Albuterol, secondaryOutcomes measure: Percentage of Children with Escalation of Respiratory Support, secondaryOutcomes measure: Mean Total Duration of Respiratory Support, secondaryOutcomes measure: Percentage of Participants placed on Adjunct Asthma Therapies, secondaryOutcomes measure: Percentage of Participants who needed Sedation, secondaryOutcomes measure: Percentage of Participants on Antibiotics, secondaryOutcomes measure: Mean PICU Length of Stay (LOS), secondaryOutcomes measure: Mean Hospital Length of Stay (LOS), eligibilityModule sex: ALL, minimumAge: 3 Years, maximumAge: 17 Years, stdAges: CHILD, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06379581, orgStudyIdInfo id: 2022-04900-02, briefTitle: Skin Cancer Diagnostics Using Photoacoustic Imaging, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-01-01, primaryCompletionDateStruct date: 2025-10-01, completionDateStruct date: 2025-10-01, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-24, sponsorCollaboratorsModule leadSponsor name: Region Skane, class: OTHER, collaborators name: Lund University, descriptionModule briefSummary: In this clinical study, photoacoustic imaging will be used on patients with suspected skin cancer (primarily melanoma, basal cell carcinoma, and squamous cell carcinoma) to determine the tumor borders both superficially and at a depth., conditionsModule conditions: Skin Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: PROSPECTIVE, enrollmentInfo count: 200, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Tumor thickness, primaryOutcomes measure: Tumor size, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Department of Ophthamology, Lund, Skåne University Hospital, status: RECRUITING, city: Lund, zip: 22185, country: Sweden, contacts name: Malin Malmsjö, Professor, role: CONTACT, phone: +46722335060, email: malin.malmsjo@med.lu.se, geoPoint lat: 55.70584, lon: 13.19321, hasResults: False
protocolSection identificationModule nctId: NCT06379568, orgStudyIdInfo id: SichuanPPHLC01, briefTitle: Risk of Aspergillus Infection in Patients With Chronic Lung Disease, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-07-01, primaryCompletionDateStruct date: 2024-01-31, completionDateStruct date: 2024-01-31, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Lin Chen, class: OTHER, descriptionModule briefSummary: Large doses of systemic corticosteroids ，severe lung tissue damage and longer COPD diagnosis may increase the risk of IPA in patients with chronic structural lung disease. By comparing the risk factors of aspergillus colonization group and aspergillus infection group, the main risk factors of aspergillus pneumonia were determined., conditionsModule conditions: Fungal Infection Lungs, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: RETROSPECTIVE, enrollmentInfo count: 209, type: ACTUAL, armsInterventionsModule interventions name: No intervention, outcomesModule primaryOutcomes measure: Descriptive statistical index, primaryOutcomes measure: Independent risk factor for aspergillus pneumonia, primaryOutcomes measure: The area under ROC curve of risk factors for aspergillus pneumonia, secondaryOutcomes measure: Threshold analysis of aspergillus pneumonia, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Sichuan Provincial People's Hospital, city: Chengdu, state: Sichuan, zip: 610072, country: China, geoPoint lat: 30.66667, lon: 104.06667, documentSection largeDocumentModule largeDocs typeAbbrev: Prot_SAP, hasProtocol: True, hasSap: True, hasIcf: False, label: Study Protocol and Statistical Analysis Plan, date: 2024-01-31, uploadDate: 2024-04-17T04:01, filename: Prot_SAP_000.pdf, size: 101446, largeDocs typeAbbrev: ICF, hasProtocol: False, hasSap: False, hasIcf: True, label: Informed Consent Form, date: 2024-01-31, uploadDate: 2024-04-14T12:03, filename: ICF_001.pdf, size: 105933, hasResults: False
protocolSection identificationModule nctId: NCT06379555, orgStudyIdInfo id: 2023-A02756-39, briefTitle: Wrist Fractures Management With Arthroscopic Assistance Under Walant - Exploratory Study, acronym: WALANPOIGNE, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06, primaryCompletionDateStruct date: 2026-01, completionDateStruct date: 2026-01, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: GCS Ramsay Santé pour l'Enseignement et la Recherche, class: OTHER, descriptionModule briefSummary: Wrist articular fractures are more difficult to treat and rehabilitation takes longer. Furthermore, these joint fractures are frequently accompanied by ligament lesions of the carpal bones.For these reasons, it is strongly recommended to check the interior of the wrist joint. This check can be done with wrist arthroscopy. Therefore, fracture reduction can be improved, "step of stairs" can be eliminated under arthroscopic control and ligament rupture of carpal bones can be treated.WALANT anesthesia (Wide Awake Local Anesthesia No Tourniquet) designates a new local anesthesia technique. This technique which allows to maintain the arm or fingers mobility offers several significant advantages:* Greater precision of the surgical procedure.* A reduction in discomfort, risks and related adverse effects to anesthesia.* Faster recovery.WALANT technique is very comfortable for patient and fits perfectly with principles of Enhanced Recovery in Surgery.In this context, this study is based on the hypothesis that it is possible to combine arthroscopy and the WALANT anesthesia technique for reducing wrist fractures, conditionsModule conditions: Wrist Fractures, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 12, type: ESTIMATED, armsInterventionsModule interventions name: Walanpoigne, outcomesModule primaryOutcomes measure: Failure percentage, secondaryOutcomes measure: Pain assessment, secondaryOutcomes measure: Patient experience, secondaryOutcomes measure: Wrist mobility, secondaryOutcomes measure: Functional characteristics of the wrist, secondaryOutcomes measure: Functional characteristics of the wrist, secondaryOutcomes measure: Complications, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06379529, orgStudyIdInfo id: USCOPD2022B, briefTitle: The COPD CARE Study: Evaluating the Impact of a Virtual-First COPD Service on Major Cardiac and Respiratory Events, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-01, primaryCompletionDateStruct date: 2025-09, completionDateStruct date: 2025-12, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: NuvoAir Medical PC, class: INDUSTRY, collaborators name: Optum, Inc., descriptionModule briefSummary: A 12 month interventional study of up to 1,050 people with COPD to determine if the NuvoAir virtual-first clinical service leads to fewer moderate and severe COPD exacerbations and cardiac events, reduces healthcare utilization, and lowers the total cost of care compared to a control cohort that receives standard care only., conditionsModule conditions: COPD Exacerbation, conditions: COPD, conditions: Cardio/Pulm: Heart Failure, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Pragmatic evaluation of a clinical service using a prospective cohort comparison of intervention vs propensity matched controls., primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 1050, type: ESTIMATED, armsInterventionsModule interventions name: NuvoAir clinical service, outcomesModule primaryOutcomes measure: Moderate & Severe Exacerbations, secondaryOutcomes measure: Severe COPD Exacerbations, secondaryOutcomes measure: Major Adverse Cardiac Event, secondaryOutcomes measure: 30-Day COPD Related Readmissions, secondaryOutcomes measure: All-Cause Hospitalizations, secondaryOutcomes measure: All-Cause Readmissions, secondaryOutcomes measure: Days Hospitalized due to COPD, secondaryOutcomes measure: Cost of Care Related to COPD, secondaryOutcomes measure: Medication Adherence, secondaryOutcomes measure: Quality of Life (QOL), otherOutcomes measure: Short-Acting Beta-Agonists Used, otherOutcomes measure: Courses of Oral Antibiotics/Steroids, otherOutcomes measure: Self-efficacy, otherOutcomes measure: Patient Activation, otherOutcomes measure: Cat Score, otherOutcomes measure: mMRC Dyspnea Scale, otherOutcomes measure: Physical Activity, eligibilityModule sex: ALL, minimumAge: 30 Years, maximumAge: 100 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06379516, orgStudyIdInfo id: NB240004-NB-V, briefTitle: Process Validation in Dermatology: Assessing Wound Creation Methods and Treatment Efficacy, statusModule overallStatus: COMPLETED, startDateStruct date: 2024-01-17, primaryCompletionDateStruct date: 2024-01-26, completionDateStruct date: 2024-02-16, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: NovoBliss Research Pvt Ltd, class: OTHER, descriptionModule briefSummary: The primary objective of this study is to validate controlled methods of wound, including 1%w/v SLS, 3%w/v SLS, and 24-24 times tape stripping, on the forearms of subjects.The study aims to standardize the procedures for creating wounds and systematically evaluate the effects of these methods on various skin parameters., conditionsModule conditions: Validation of the Process of Wound Creation and Evaluation, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Proof of science/concept, primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: NONE, enrollmentInfo count: 5, type: ACTUAL, armsInterventionsModule interventions name: Moisturising Cream (5%), interventions name: Moisturising Cream (10%), interventions name: Coconut Oil, outcomesModule primaryOutcomes measure: Trans Epidermal Water Loss (TEWL), primaryOutcomes measure: Skin hydration, primaryOutcomes measure: Skin surface topography, secondaryOutcomes measure: Dermatological Assessment, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: NovoBliss Research Pvt Ltd, city: Gandhinagar, state: Gujarat, zip: 382421, country: India, geoPoint lat: 23.21667, lon: 72.68333, hasResults: False
protocolSection identificationModule nctId: NCT06379503, orgStudyIdInfo id: 2021/37-04, briefTitle: Effect of Heart Yoga Applıed To Patıents Undergoıng Cardıovascular Surgery on Sleep, Depressıon And Qualıty of Lıfe, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-12-15, primaryCompletionDateStruct date: 2023-01-18, completionDateStruct date: 2023-06-18, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Dokuz Eylul University, class: OTHER, descriptionModule briefSummary: This type of study is a randomized controlled trial. The aim is to contribute to the literature by comparing the effects of heart yoga on the depression level, sleep and quality of life of patients who do and do not do heart yoga.The main elements it aims to answer are:* Heart yoga applied to patients who have undergone heart surgery improves their sleep quality compared to those who have not.* Heart yoga applied to patients who have undergone heart surgery reduces the level of depression compared to those who have not.* Heart yoga applied to patients who have undergone heart surgery increases the quality of life compared to those who have not.Patients who accept the study will practice heart yoga simultaneously with heart yoga videos via an online link every other day for 12 weeks after heart surgery.Researchers will compare intervention and control groups to see if there are any effects on sleep quality, depression level, and quality of life., conditionsModule conditions: Cardiac Disease, conditions: Yoga, conditions: Nursing Caries, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: SEQUENTIAL, interventionModelDescription: randomized controlled trial, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ACTUAL, armsInterventionsModule interventions name: HEART YOGA, interventions name: routine nursing care, outcomesModule primaryOutcomes measure: sleep quality, primaryOutcomes measure: depression, primaryOutcomes measure: life quality, eligibilityModule sex: ALL, minimumAge: 45 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Dokuz Eylül Üniversitesi Hastanesi, city: İ̇zmi̇r, state: Balçova, zip: 35330, country: Turkey, geoPoint lat: 38.41273, lon: 27.13838, hasResults: False
protocolSection identificationModule nctId: NCT06379477, orgStudyIdInfo id: refractive error surprises, briefTitle: Correction of Refractive Error Surprises After Cataract Surgery in Adults, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-01, primaryCompletionDateStruct date: 2025-05-31, completionDateStruct date: 2025-06-30, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: A refractive surprise can be defined as the failure to achieve the intended postoperative refractive target or the presentation of unexpected and, unwanted post-operative refractive error. It can cause anisometropia or dominance switch and is a source of patient dissatisfaction due to unmet expectations.The best way to manage refractive surprise is to prevent it. The 2017 NICE guidelines on the management of cataracts provide advice on prevention of refractive surprise through accurate biometry, A-constant optimisation, intraocular lens (IOL) formula selection and avoiding wrong lens implant errors.Benchmark standards for NHS cataract surgery dictate that 85% of eyes should be within 1 dioptre (D) and 55% within 0.5D of target spherical equivalent refraction following surgery., conditionsModule conditions: Refractive Errors, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 63, type: ESTIMATED, armsInterventionsModule interventions name: Refractive surgeries, outcomesModule primaryOutcomes measure: Diagnosis and treatment of the resulting refractive error surprises, eligibilityModule sex: ALL, minimumAge: 55 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06379464, orgStudyIdInfo id: CALM2303, briefTitle: Screening of New Markers of Gut Microbiota in Stroke and Depression: a Cross-sectional Study, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-09-01, primaryCompletionDateStruct date: 2024-06-30, completionDateStruct date: 2024-12-30, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Zhujiang Hospital, class: OTHER, descriptionModule briefSummary: Objectives of Study： Through the cross-sectional study of stroke and depression, key biomarkers are targeted by screening disease-associated intestinal bacteria, metabolites and immune factors through multi-omics techniques., conditionsModule conditions: Acute Ischaemic Stroke, conditions: Depression, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 320, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: The severity of neurological damage in stroke patients, primaryOutcomes measure: The functional recovery outcomes after stroke, primaryOutcomes measure: The severity of symptoms in patients with depression, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Zhujiang Hospital of Southern Medical University, status: RECRUITING, city: Guanzhou, state: Guangdong, zip: 510145, country: China, contacts name: Hongwei Zhou, Professor, role: CONTACT, phone: 186 8848 9622, email: hzhou@smu.edu.cn, hasResults: False