protocolSection identificationModule nctId: NCT06294145, orgStudyIdInfo id: U24AG072699, type: NIH, link: https://reporter.nih.gov/quickSearch/U24AG072699, briefTitle: Effects of a Wellbeing Intervention on Inflammation Through Reward and Threat Processes, acronym: SAVOR, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-07, primaryCompletionDateStruct date: 2025-01-31, completionDateStruct date: 2025-01-31, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: University of California, Los Angeles, class: OTHER, collaborators name: Network for Emotional Wellbeing, collaborators name: National Institutes of Health (NIH), descriptionModule briefSummary: This study aims to evaluate how savoring influences reward and threat processes and downstream inflammation. Savoring is designed to enhance positive affect, which may blunt stress responses and reduce downstream inflammation. The investigators aim to examine changes in the brain following the savoring intervention. The investigators are particularly interested in changes in brain activity that are correlated with changes in inflammation-related markers in the blood. In this single-armed pilot trial, the investigators will assess how savoring alters reactivity to rewarding and threatening experiences, and then examine related changes in downstream inflammation. The investigators intend to recruit 20 undergraduate students to complete a 7-week standardized savoring intervention. Participants will complete brain scans, daily diaries, questionnaires, a behavioral task, and blood collection at pre- and post-intervention assessments., conditionsModule conditions: Low Positive Affect, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: All 20 participants will be assigned to the same 7-week savoring intervention., primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Savoring Intervention, outcomesModule primaryOutcomes measure: Positive affect, secondaryOutcomes measure: Negative affect, secondaryOutcomes measure: Depression, secondaryOutcomes measure: Anxiety, secondaryOutcomes measure: Perceived stress, secondaryOutcomes measure: Psychological wellbeing, secondaryOutcomes measure: Emotions, secondaryOutcomes measure: Reward, secondaryOutcomes measure: Savoring strategies, secondaryOutcomes measure: Interoception, secondaryOutcomes measure: Inflammation, secondaryOutcomes measure: Sustained Attention, secondaryOutcomes measure: Neural Reward Activity, secondaryOutcomes measure: Neural Threat Activity, secondaryOutcomes measure: Daily diary, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 22 Years, stdAges: ADULT, contactsLocationsModule locations facility: University of California, Los Angeles, status: RECRUITING, city: Los Angeles, state: California, zip: 90095, country: United States, contacts name: Robin B Blades, role: CONTACT, phone: 510-520-5780, email: robinblades@gmail.com, contacts name: Julienne Bower, PhD, role: CONTACT, phone: 310-825-3004, email: jbower@g.ucla.edu, contacts name: Julienne Bower, PhD, role: PRINCIPAL_INVESTIGATOR, contacts name: Chloe Boyle, PhD, role: SUB_INVESTIGATOR, contacts name: Naomi Eisenberger, PhD, role: SUB_INVESTIGATOR, contacts name: Steve Cole, PhD, role: SUB_INVESTIGATOR, contacts name: Michelle Craske, PhD, role: SUB_INVESTIGATOR, contacts name: Aileen Echiverri, PhD, role: SUB_INVESTIGATOR, contacts name: Robin Blades, role: SUB_INVESTIGATOR, geoPoint lat: 34.05223, lon: -118.24368, hasResults: False