protocolSection identificationModule nctId: NCT06387355, orgStudyIdInfo id: SURG-006-23S, briefTitle: Diagnosis and Treatment of CAD in Severe PAD After Lower Extremity Revascularization, acronym: CAD in sPAD, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-08-01, primaryCompletionDateStruct date: 2027-08-01, completionDateStruct date: 2029-08-01, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: VA Office of Research and Development, class: FED, descriptionModule briefSummary: Peripheral artery disease, lack or blood flow to the legs, has a high prevalence in the Veteran population. In patients with severe peripheral artery disease that requires an endovascular or surgical intervention for lower leg revascularization, the long-term mortality of approximately 50% is worse that most cancers. The goal of this study is to develop a management strategy to improve cardiovascular outcomes in this high-risk peripheral artery disease population after lower extremity revascularization., conditionsModule conditions: Peripheral Artery Disease, conditions: Coronary Artery Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: This will be a parallel interventional model to assign participants to a treatment strategy in a clinical study, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 450, type: ESTIMATED, armsInterventionsModule interventions name: Coronary computed topography (CT) angiography with FFR-CT, outcomesModule primaryOutcomes measure: Major adverse cardiovascular events (MACE), secondaryOutcomes measure: Cardiovascular-related death, secondaryOutcomes measure: Myocardioal infarction, secondaryOutcomes measure: All-cause mortality, secondaryOutcomes measure: Amputation-free survival, eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 85 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Rocky Mountain Regional VA Medical Center, Aurora, CO, city: Aurora, state: Colorado, zip: 80045, country: United States, contacts name: Clay Quint, MD PhD, role: CONTACT, phone: 210-606-2940, email: clay.quint@va.gov, contacts name: Clay Quint, MD PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.72943, lon: -104.83192, locations facility: North Florida/South Georgia Veterans Health System, Gainesville, FL, city: Gainesville, state: Florida, zip: 32608-1135, country: United States, contacts name: Salvatore Scali, MD, role: CONTACT, phone: 352-376-1611, geoPoint lat: 29.65163, lon: -82.32483, locations facility: Louis Stokes VA Medical Center, Cleveland, OH, city: Cleveland, state: Ohio, zip: 44106-1702, country: United States, contacts name: Michael Rosenbaum, MD, role: CONTACT, phone: 216-791-3800, geoPoint lat: 41.4995, lon: -81.69541, locations facility: VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, city: Pittsburgh, state: Pennsylvania, zip: 15240, country: United States, contacts name: Edith Tzeng, MD, role: CONTACT, phone: 866-482-7488, geoPoint lat: 40.44062, lon: -79.99589, locations facility: Tennessee Valley Healthcare System Nashville Campus, Nashville, TN, city: Nashville, state: Tennessee, zip: 37212-2637, country: United States, contacts name: John Curci, MD, role: CONTACT, phone: 615-327-4751, geoPoint lat: 36.16589, lon: -86.78444, locations facility: VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, city: Dallas, state: Texas, zip: 75216-7167, country: United States, contacts name: Shirling Tsai, MD, role: CONTACT, phone: 469-797-2100, geoPoint lat: 32.78306, lon: -96.80667, locations facility: VA Puget Sound Health Care System Seattle Division, Seattle, WA, city: Seattle, state: Washington, zip: 98108-1532, country: United States, contacts name: Gale Tang, MD, role: CONTACT, phone: 800-329-8387, geoPoint lat: 47.60621, lon: -122.33207, hasResults: False