protocolSection identificationModule nctId: NCT06263920, orgStudyIdInfo id: 288703, briefTitle: Neurofrailty: A Study of Late-onset Epilepsy and Its Associations, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-05-05, primaryCompletionDateStruct date: 2027-01-12, completionDateStruct date: 2027-01-12, studyFirstPostDateStruct date: 2024-02-16, lastUpdatePostDateStruct date: 2024-02-16, sponsorCollaboratorsModule leadSponsor name: Lancashire Teaching Hospitals NHS Foundation Trust, class: OTHER, descriptionModule briefSummary: We don't know a great deal about why some people develop seizures in adulthood, but some researchers think that it might tell us something about the brain. A small number of people with first seizure in adulthood go on to experience problems like stroke or dementia later in life. However, stroke and dementia are common diseases, so we don't know whether there is a real association between these conditions. When people develop their first seizure in adult life, this is sometimes called Late-Onset Epilepsy. Through the NeuroFrailty study, we will observe 'brain health' over the years following the onset of a seizure, and I hope that it might give us more information about people with these kinds of seizures.The NeuroFrailty study involves observing people from the time of diagnosis of first seizure. At this time, we will look at investigations such as blood tests, blood pressure, brain scans, alongside other diagnoses which might tell us whether there are differences compared to people without seizures. For some people, we will also look in greater depth at lifestyle including exercise, driving, family planning, and memory assessments.Over the following years, we will look at how things change: for example whether there are changes in memory, new diagnoses, medication changes and how lifestyle has changed. Because there is so little research in this area, it is very difficult to predict what might happen. For example, some people can experience worse memory because of medication side effects; on the other hand, good seizure control following a diagnosis can sometimes lead to improved memory. Over years, it may become clear that some diseases are more likely in people with late-onset epilepsy than in people without such a diagnosis. You will receive a yearly newsletter to keep you updated on everything we learn about late-onset epilepsy.Purpose and BackgroundMost of the time, we do not know why an adult develops epilepsy. Some researchers think there may be a connection between epilepsy which starts in adulthood, and increased risk of stroke or dementia in the future. However, there is very little research or evidence in this area, so we cannot say whether this is true.What does taking part involve?This study is an observational study, which means that the management of participants' seizure disorder will not be affected if they choose to take part in this study. The purpose of this study is to watch participants over the course of several years, to find out more about seizures which start in adulthood.Participants can choose the level of involvement that is right for them.1. LOW involvement. A researcher will check hospital and General Practice (GP records) once or twice per year, for the LIMITED AND SPECIFIC purpose of checking: medications, any new diagnoses, investigations associated with stroke risk (such as cholesterol, blood pressure, heart trace) and any brain scans that have been performed. I will not have access to more detailed information, such as conversations between a participant and their GP.2. HIGH involvement. This involves being contacted by telephone once per year for 15-30 minutes to ask questions assessing memory and enquiring about lifestyle, such as exercise, smoking and alcohol use.3. VERY HIGH involvement. These participants will be contacted for a longer telephone conversation 30-45 minutes once per year about their experience of how epilepsy has affected home life, work and medications.If someone decides in the future that they don't want to be involved, they can withdraw from the study. However, once the study is completely finished, the information will be completely anonymous, which means that I won't be able to find individual's information in order to delete it.Glossary Seizure disorder = any disorder which involved having experienced at least one seizure. First seizure and epilepsy both can be classed as a form of seizure disorder.Neurofrailty = A condition whereby a person is at risk of stroke or dementia., conditionsModule conditions: Late Onset Epilepsy, conditions: Stroke, conditions: Dementia, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 360, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: At the time of onset, do people with late-onset epilepsy have higher prevalence of cerebrovascular disease risk factors compared to a control population?, primaryOutcomes measure: Quality of Life - how of chronic illness is mediated, secondaryOutcomes measure: What is the absolute and relative incidence of stroke and dementia in people after the onset of LOE compared to the background population?, secondaryOutcomes measure: Which anti-epileptic drugs are used in current practice in LOE, and how are they tolerated?, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Lancashire Teaching Hospitals NHS, status: RECRUITING, city: Preston, state: Lancashire, zip: PR2 9HT, country: United Kingdom, contacts name: Kina Bennett, role: CONTACT, phone: (+44) 01772 522031, email: kina.bennett@lthtr.nhs.uk, contacts name: Research Access, role: CONTACT, email: research.access@lthtr.nhs.uk, contacts name: Jasmine Wall, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.76282, lon: -2.70452, hasResults: False