protocolSection identificationModule nctId: NCT06349538, orgStudyIdInfo id: 35-435 ex 22/23, briefTitle: Identifying Markers of Disease Subtypes and Disease Progression in the Syndrome of Essential Tremor, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2024-04-04, primaryCompletionDateStruct date: 2026-04-30, completionDateStruct date: 2034-04-30, studyFirstPostDateStruct date: 2024-04-05, lastUpdatePostDateStruct date: 2024-04-16, sponsorCollaboratorsModule leadSponsor name: Medical University of Graz, class: OTHER, descriptionModule briefSummary: The goal of this observational study is to learn about epidemiology, biologic markers, disease subtypes and possible prognostic factors in essential tremor (ET) patients. The main question\[s\] it aims to answer are:* The prevalence of ET-plus compared to ET in a prospectively collected ET population.* To assess in detail the heterogenous group of ET patients using comprehensive clinical (motor and non-motor scales, questionnaires), imaging \[magnetic resonance imaging (MRI), sonography of substantia nigra and cerebral vessels\], neurophysiological (tremor analysis, digital spiral drawing) and laboratory markers (sGFAP, sNfL, routine laboratory parameters).* To assess possible non-invasive markers of neurodegeneration in ET patients (optic coherence tomography, alpha-synuclein in olfactory mucosa)Participants will be asked to undergo the above mention evaluation at baseline and at follow-up approx. 5 years later.Researchers will compare the findings within the ET group to independently existing cohorts of healthy controls and/or patients with other movement disorders like Parkinson's disease., conditionsModule conditions: Essential Tremor, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Clinical examination, blood draw, cerebral MRI, sonography, tremor analysis, OCT, olfactory mucosa swab., outcomesModule primaryOutcomes measure: Prevalence of ET-plus, secondaryOutcomes measure: Age of ET patients, secondaryOutcomes measure: Sex of ET patients, secondaryOutcomes measure: Family history, secondaryOutcomes measure: Symptom leading to ET-plus classification, secondaryOutcomes measure: current and former medication for essential tremor, secondaryOutcomes measure: subjective disease course of ET, secondaryOutcomes measure: responsivity to alcohol, secondaryOutcomes measure: presence of cardiovascular risk factors, secondaryOutcomes measure: MDS-UPDRS (Movement Disorder Society Unified Parkinson's Disease Rating Scale) parts I-IV, secondaryOutcomes measure: modified Essential Tremor Rating Assessment Scale (mTETRAS), secondaryOutcomes measure: Scale for the assessment and rating of ataxia (SARA), secondaryOutcomes measure: Verbal fluency animals (part of the CERAD-plus test battery), secondaryOutcomes measure: Boston Naming Test (part of the CERAD-plus test battery), secondaryOutcomes measure: Mini Mental State Examination Test (MMSE; part of the CERAD-plus test battery), secondaryOutcomes measure: word list learning (part of the CERAD-plus test battery), secondaryOutcomes measure: constructive praxis (part of the CERAD-plus test battery), secondaryOutcomes measure: word list recall (part of the CERAD-plus test battery), secondaryOutcomes measure: word list recognition (part of the CERAD-plus test battery), secondaryOutcomes measure: constructive praxis recall (part of the CERAD-plus test battery), secondaryOutcomes measure: Trail Making Test A (part of the CERAD-plus test battery), secondaryOutcomes measure: Trail Making Test B (part of the CERAD-plus test battery), secondaryOutcomes measure: s-words (part of the CERAD-plus test battery), secondaryOutcomes measure: Frontal Assessment Battery (FAB), secondaryOutcomes measure: Geriatric Depression Scale (GDS), secondaryOutcomes measure: Hospital Anxiety and Depression Scale (HADS), secondaryOutcomes measure: Non-Motor Symptoms Scale for Parkinson's Disease (NMSS), secondaryOutcomes measure: RBD Screening Questionnaire, secondaryOutcomes measure: Global Physical Activity Questionnaire (GPAQ), secondaryOutcomes measure: Quality of Life in Essential Tremor Questionnaire (QUEST), secondaryOutcomes measure: University of Pennsylvania Smell Identification Test (UPSIT), secondaryOutcomes measure: Montreal Cognitive Assessment (MOCA), secondaryOutcomes measure: Auditory verbal learning test, secondaryOutcomes measure: Symbol Digit Modalities Test (SDMT), secondaryOutcomes measure: Brief Visuospatial Memory Test, secondaryOutcomes measure: Comprehensive trail making test 4, secondaryOutcomes measure: Comprehensive trail making test 5, secondaryOutcomes measure: Regensburg word fluency test, secondaryOutcomes measure: EQ-5D, secondaryOutcomes measure: resilience scale (RS-13), secondaryOutcomes measure: Pittsburgh Sleep Quality Index (PSQI), secondaryOutcomes measure: Digital Spiral Drawing, secondaryOutcomes measure: Schellong Test, secondaryOutcomes measure: serum glial fibrillary acidic protein (sGFAP), secondaryOutcomes measure: serum neurofilament light (sNfL), secondaryOutcomes measure: Transcranial sonography, secondaryOutcomes measure: tremor analysis, secondaryOutcomes measure: cerebral MRI, secondaryOutcomes measure: cerebral MRI, secondaryOutcomes measure: cerebral MRI, secondaryOutcomes measure: cerebral MRI, secondaryOutcomes measure: cerebral MRI, secondaryOutcomes measure: cerebral MRI, secondaryOutcomes measure: optic coherence tomography (OCT), secondaryOutcomes measure: optic coherence tomography (OCT), secondaryOutcomes measure: optic coherence tomography (OCT), secondaryOutcomes measure: optic coherence tomography (OCT), secondaryOutcomes measure: Olfactory mucosa swab, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Medical University of Graz, city: Graz, zip: 8036, country: Austria, geoPoint lat: 47.06667, lon: 15.45, hasResults: False