hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06347588, orgStudyIdInfo id: OBI&ICI, briefTitle: Risk of Reactivation of Occult Hepatitis B in Cancer Patients During Immunotherapy., statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2026-05, completionDateStruct date: 2026-12, studyFirstPostDateStruct date: 2024-04-04, lastUpdatePostDateStruct date: 2024-04-05, sponsorCollaboratorsModule leadSponsor name: Fondazione IRCCS Policlinico San Matteo di Pavia, class: OTHER, descriptionModule briefSummary: The goal of this observational study is to evalue the cumulative proportion of patients with OBI who do not develop HBsAg seroreversion and/or an increase of serum HBV DNA by at least 1 log above the lower limit of detection of the assay in a patient who had previously undetectable HBsAg and HBV DNA in serum during the study., conditionsModule conditions: Occult Hepatitis B Infection in Cancer Patients, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Observational: Blood sample of HVB-specific Elispot assay, HBSAg, HBV-DNA, outcomesModule primaryOutcomes measure: To evaluate the cumulative proportion of patients with OBI who do not develop one seroreversion of HBsAg and/or an increase in serum HBV DNA of at least 1 log above the lower limit of detection of the test in a patient who had previously HBsAg and HBV, secondaryOutcomes measure: Evaluation of the incidence of reactivation in patients during immunotherapy, secondaryOutcomes measure: Evaluation of the association between HBV-specific T-cell response and HBV reactivation, secondaryOutcomes measure: Analysis of the incidence of reactivation of HBV in patients with p-OBI according to tumor characteristics (histology and stage) and type and line of treatment (immunotherapy, combined treatment with chemotherapy + immunotherapy)., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Irccs San Matteo Pavia, city: Pavia, state: PV, zip: 27100, country: Italy, contacts name: Alessandra Ferrari, role: CONTACT, phone: 0382.503689, email: alessandra.ferrari@smatteo.pv.it, contacts name: ANGIOLETTA LASAGNA, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.19205, lon: 9.15917, hasResults: False
protocolSection identificationModule nctId: NCT06347562, orgStudyIdInfo id: 934, briefTitle: Optical Genome Mapping for the Diagnosis of Neurodevelopmental Disorders, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-06-15, primaryCompletionDateStruct date: 2025-06-14, completionDateStruct date: 2025-06-14, studyFirstPostDateStruct date: 2024-04-04, lastUpdatePostDateStruct date: 2024-04-04, sponsorCollaboratorsModule leadSponsor name: IRCCS Eugenio Medea, class: OTHER, descriptionModule briefSummary: to evaluate the ability of the Optical genome Mapping (OGM) approach to detect simple and complex constitutional chromosomal aberrations of clinical relevance, which had previously been identified with standard diagnostic approaches (karyotyping, FISH, CNV-microarray) in the context of neurodevelopmental disorders (NDDs) with/wo congenital anomalies (CA), conditionsModule conditions: Neurodevelopmental Disorder (Diagnosis), designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 58, type: ESTIMATED, armsInterventionsModule interventions name: Optical Genome Mapping, outcomesModule primaryOutcomes measure: Diagnostic concordance rate, eligibilityModule sex: ALL, minimumAge: 2 Years, maximumAge: 17 Years, stdAges: CHILD, contactsLocationsModule locations facility: Scientific Institute E. Medea, status: RECRUITING, city: Bosisio Parini, state: Lecco, zip: 23842, country: Italy, contacts name: Clara Bonaglia, PhD, role: CONTACT, phone: 031877913, phoneExt: +39, email: clara.bonaglia@lanostrafamiglia.it, geoPoint lat: 45.80075, lon: 9.29, hasResults: False
protocolSection identificationModule nctId: NCT06347549, orgStudyIdInfo id: HE-SF2024/09, briefTitle: The Impact of Diaphragmatic Breathing Instructions and Inspiratory Pressures on Diaphragm Contraction in Healthy Adults, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-15, primaryCompletionDateStruct date: 2026-04-15, completionDateStruct date: 2026-04-15, studyFirstPostDateStruct date: 2024-04-04, lastUpdatePostDateStruct date: 2024-04-04, sponsorCollaboratorsModule leadSponsor name: Hong Kong Metropolitan University, class: OTHER, descriptionModule briefSummary: This is a cross-sectional obsessional study.This study aims (1) to investigate the relationship between sternocleidomastoid muscle recruitment and diaphragm thickness fraction during increasing inspiratory resistance in healthy adults; (2) to compare diaphragmatic and sternocleidomastoid muscle recruitment patterns with and without a standard diaphragmatic breathing instruction with increasing inspiratory resistance in healthy adults.Participants will be asked to breathe through a pressure threshold inspiratory loading device under different inspiratory resistances with and without a standard diaphragmatic breathing instruction. sternocleidomastoid muscle activity will be measured with surface electromyography, and diaphragm thickness will be assessed with ultrasonography., conditionsModule conditions: Diaphragm, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CROSSOVER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 36, type: ESTIMATED, armsInterventionsModule interventions name: Various intensities of inspiratory muscle training, outcomesModule primaryOutcomes measure: Diaphragmatic thickening fraction, secondaryOutcomes measure: Muscle activation of the sternocleidomastoid muscle, secondaryOutcomes measure: Perceived Exertion Borg scale, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, documentSection largeDocumentModule largeDocs typeAbbrev: Prot_SAP, hasProtocol: True, hasSap: True, hasIcf: False, label: Study Protocol and Statistical Analysis Plan, date: 2024-03-25, uploadDate: 2024-03-28T00:38, filename: Prot_SAP_000.pdf, size: 185477, largeDocs typeAbbrev: ICF, hasProtocol: False, hasSap: False, hasIcf: True, label: Informed Consent Form, date: 2024-03-25, uploadDate: 2024-03-28T00:39, filename: ICF_001.pdf, size: 204027, hasResults: False
protocolSection identificationModule nctId: NCT06347523, orgStudyIdInfo id: FirstShantou, briefTitle: VR-Based Preoperative Rehabilitation Program for Patients Undergoing Anterior Cruciate Ligament (ACL) Reconstruction, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-02, primaryCompletionDateStruct date: 2024-10-01, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-04-04, lastUpdatePostDateStruct date: 2024-04-04, sponsorCollaboratorsModule leadSponsor name: First Affiliated Hospital of Shantou University Medical College, class: OTHER, descriptionModule briefSummary: Between April 2, 2024, and October 1, 2024, a study will be conducted at the Department of Orthopedics in the First Affiliated Hospital of Shantou University Medical College involving 120 patients who will undergo anterior cruciate ligament reconstruction surgery. They will be randomly divided into two groups: an experimental group and a control group., conditionsModule conditions: Anterior Cruciate Ligament (ACL) Reconstruction, conditions: Preoperative Rehabilitation, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 120, type: ESTIMATED, armsInterventionsModule interventions name: The VR-based preoperative rehabilitation program;, interventions name: standard nursing care,, outcomesModule primaryOutcomes measure: knee joint range of motion, primaryOutcomes measure: Lysholm knee function score, secondaryOutcomes measure: SAS self-rating anxiety scale scale, secondaryOutcomes measure: SDS self-rating depression scale scale, secondaryOutcomes measure: Visual Analog Scale pain score, secondaryOutcomes measure: Barthel Index for basic activities of daily living, secondaryOutcomes measure: time to first ambulation post-surgery, otherOutcomes measure: postoperative complications, otherOutcomes measure: nursing satisfaction, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: "The First Affiliated Hospital of Shantou University Medical College, status: RECRUITING, city: Shantou, state: Guangdong, zip: 515000, country: China, contacts name: Zeshan Chen, role: CONTACT, phone: +8613592896271, geoPoint lat: 23.36814, lon: 116.71479, hasResults: False
protocolSection identificationModule nctId: NCT06347510, orgStudyIdInfo id: E-25403353-050.99-174660, briefTitle: The Level of sST2 in Pediatric Heart Failure, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-08-16, primaryCompletionDateStruct date: 2024-02-16, completionDateStruct date: 2024-02-16, studyFirstPostDateStruct date: 2024-04-04, lastUpdatePostDateStruct date: 2024-04-04, sponsorCollaboratorsModule leadSponsor name: Eskisehir Osmangazi University, class: OTHER, descriptionModule briefSummary: Introduction: Suppression of tumorigenicity 2 (ST2) is a receptor member belongs to the Interleukin-1 (IL-1) family. The ligand and soluble versions are its two isoforms. The interleukin-33-ST2 ligand complexs development provides protection against heart fibrosis and hypertrophy. Investigations on heart failure in adults has demonstrated that it does not change by age, body mass index (BMI), creatinine, hemoglobin, and albumin levels, in contrast to NT pro brain natriuretric peptit. In adult heart failure patients, it has been demonstrated to be an independent predictor of mortality and cardiovascular events. The most recent guideline recommends using it as class 2b in the diagnosis of adult heart failure. Studies on ST2 in children are rare. The purpose of this study is to assess the prognostic value of ST2 for cardiovascular events in young individuals suffering from heart failure.Method: The study included pediatric patients (0-18 years old) with congenital heart disease or cardiomyopathy who needed medical care as well as surgical or interventional treatment. Height, weight, gender, saturation, heart failure classification (Ross or New York heart Assosiation), medications taken, the electrocardiogram, echocardiography, Pro BNP, and sST2 values of the patients, as well as any hospitalization, lower respiratory tract infection, organ dysfunction, or need for angiography or surgery during follow-up Data on arrhythmia and death were gathered during a 1-year follow-up. The SPSS software application was used to carry out the statistical analysis., conditionsModule conditions: Congenital Heart Disease, conditions: Congestive Heart Failure, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: PROSPECTIVE, enrollmentInfo count: 59, type: ACTUAL, armsInterventionsModule interventions name: Suppression of tumorigenicity 2 (ST2), outcomesModule primaryOutcomes measure: Soluble suppression of tumorigenicity levels with or without major cardiovascular event, primaryOutcomes measure: Pro BNP levels, primaryOutcomes measure: Major cardiovascular event ( such as hospitalization, lower respiratory tract infection, organ dysfunction, or need for angiography or surgery), eligibilityModule sex: ALL, minimumAge: 1 Month, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Eskisehir Osmangazi University, city: Eskisehir, state: Odunpazarı, zip: 26040, country: Turkey, geoPoint lat: 39.77667, lon: 30.52056, hasResults: False
protocolSection identificationModule nctId: NCT06347458, orgStudyIdInfo id: BG-CA-23-001, briefTitle: BG1805 Injection in the Treatment of Relapsed or Refractory Acute Myeloid Leukemia in Children, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2027-04, completionDateStruct date: 2027-08, studyFirstPostDateStruct date: 2024-04-04, lastUpdatePostDateStruct date: 2024-04-04, sponsorCollaboratorsModule leadSponsor name: Guangzhou Bio-gene Technology Co., Ltd, class: INDUSTRY, descriptionModule briefSummary: This is a single-arm, single-dose dose-escalation and dose-expansion study., conditionsModule conditions: Leukemia, conditions: Acute Myeloid Leukemia, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 24, type: ESTIMATED, armsInterventionsModule interventions name: BG1805, outcomesModule primaryOutcomes measure: 1.Dose Limited Toxicity Rate, primaryOutcomes measure: 2.Incidence of Treatment-Emergent Adverse Events, secondaryOutcomes measure: 3.Concentration of CAR-T cells after Infusion (PK), secondaryOutcomes measure: 4.overall response rate, ORR, secondaryOutcomes measure: 5.Concentration of Cytokine after Infusion (PD), eligibilityModule sex: ALL, minimumAge: 3 Years, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06347445, orgStudyIdInfo id: GSM012024, briefTitle: Turkish Nationwide SurvEy of Glycemic and Other Metabolic Parameters of Patients With Diabetes Mellitus-2 (TEMD-2 Study), acronym: TEMD-2, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-10-01, primaryCompletionDateStruct date: 2023-01-30, completionDateStruct date: 2023-01-30, studyFirstPostDateStruct date: 2024-04-04, lastUpdatePostDateStruct date: 2024-04-04, sponsorCollaboratorsModule leadSponsor name: Gulhane School of Medicine, class: OTHER, descriptionModule briefSummary: This study evaluates the metabolic control status, cardiovascular risk and frequency of comorbidities in diabetic patients followed in tertiary treatment centers in Turkey., conditionsModule conditions: Diabetes Mellitus, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 5707, type: ACTUAL, armsInterventionsModule interventions name: There is no intervention., outcomesModule primaryOutcomes measure: Glycemia control status of Turkish adult patients with diabetes mellitus, primaryOutcomes measure: Blood pressure control status of Turkish adult patients with diabetes mellitus, primaryOutcomes measure: Lipid control status of Turkish adult patients with diabetes mellitus., primaryOutcomes measure: Weight control status of Turkish adult patients with diabetes mellitus., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Gulhane School of Medicine Department of Endocrinology and Metabolism, city: Ankara, zip: 06010, country: Turkey, geoPoint lat: 39.91987, lon: 32.85427, hasResults: False
protocolSection identificationModule nctId: NCT06347432, orgStudyIdInfo id: 24-119-H, briefTitle: Em-power: Maximizing Functional Independence for Children With Severe Cerebral Palsy, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-07, primaryCompletionDateStruct date: 2027-03, completionDateStruct date: 2027-03, studyFirstPostDateStruct date: 2024-04-04, lastUpdatePostDateStruct date: 2024-04-04, sponsorCollaboratorsModule leadSponsor name: Grand Valley State University, class: OTHER, descriptionModule briefSummary: For children with severe cerebral palsy, a powered wheelchair (PWC) may provide their only option for functional mobility and independence. PWC use is often restricted to a small percentage of children who can quickly demonstrate proficient PWC skills within a single 30-minute PWC trial. This 2-arm, parallel group, single blinded, pre-test-post-test randomized controlled trial will test our hypothesis that an 8-week PWC skills training intervention will produce greater improvements in children's PWC skills capacity immediately after the intervention and at an 8-week follow-up assessment., conditionsModule conditions: Cerebral Palsy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 16, type: ESTIMATED, armsInterventionsModule interventions name: Power wheelchair skills training using the IndieTrainer system, outcomesModule primaryOutcomes measure: Change in understanding how to use a power wheelchair, primaryOutcomes measure: Change in power wheelchair skill performance, secondaryOutcomes measure: Change in parental/caregiver perceptions of changes in their children's performance of power wheelchair skill performance, secondaryOutcomes measure: Change in children's perceptions of changes in their performance of power wheelchair skill performance, eligibilityModule sex: ALL, minimumAge: 5 Years, maximumAge: 17 Years, stdAges: CHILD, contactsLocationsModule locations facility: Grand Valley State University, city: Grand Rapids, state: Michigan, zip: 49503, country: United States, geoPoint lat: 42.96336, lon: -85.66809, hasResults: False
protocolSection identificationModule nctId: NCT06347419, orgStudyIdInfo id: Iayas8, briefTitle: Body Awareness and Spinal Stability in Scoliosis, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-30, primaryCompletionDateStruct date: 2024-06-30, completionDateStruct date: 2024-07-30, studyFirstPostDateStruct date: 2024-04-04, lastUpdatePostDateStruct date: 2024-04-04, sponsorCollaboratorsModule leadSponsor name: Gazi University, class: OTHER, descriptionModule briefSummary: Thirty volunteer patients diagnosed with scoliosis by a specialist physician at Gazi University Hospital Orthopedics and Traumatology Department and subsequently referred to Gazi University Physiotherapy and Rehabilitation Department for exercise training will be included in the study. The lumbar Pressure Measurement Test with Stabilizer and Rotation Stability Tests will be utilized to evaluate the spinal stability of the patients. Body awareness will be assessed using the Body Awareness Survey, comprising 18 questions. All assessments will be conducted at the Orthopedic Rehabilitation Clinic within the relevant department.The results obtained from this study will elucidate the relationship between body awareness and spinal stability in individuals with scoliosis., conditionsModule conditions: Scoliosis Idiopathic, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule interventions name: Physiotherapy evaluation, outcomesModule primaryOutcomes measure: Spinal stability, primaryOutcomes measure: Rotary Stability, primaryOutcomes measure: Body Awareness, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Gazi University Hospital, city: Ankara, zip: 06500, country: Turkey, contacts name: İnci H Ayas, role: CONTACT, phone: 0 312 216 26 21, email: inciayass@gmail.com, geoPoint lat: 39.91987, lon: 32.85427, hasResults: False
protocolSection identificationModule nctId: NCT06347406, orgStudyIdInfo id: FSKesihatan, briefTitle: Effects of Combined Physiotherapy Management and Education, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2025-04-01, completionDateStruct date: 2025-04-01, studyFirstPostDateStruct date: 2024-04-04, lastUpdatePostDateStruct date: 2024-04-04, sponsorCollaboratorsModule leadSponsor name: Fakulti Sains Kesihatan, class: OTHER, descriptionModule briefSummary: This observational study aims to determine the effects of combined physiotherapy programs and education in patellofemoral pain syndrome. The main questions it aims to answer are:* Are there any effects of combined physiotherapy program among individuals with PFPS on:  i) Pain ii) Muscle functions (strength, muscle bulk, flexibility) iii) Knee muscle functional performance (anteromedial lunge, step-down, bilateral squat, and balance and reach) iv) Kinesiophobia v) Quality of life Participants will be* Measure for the anthropometrics data including body weight, height, and BMI.* Answer the Numerical Pain Rating scale* Abswe Malay version of KOOS-PF and TAMPA scale.* Once they finished with the questionnaire, the participants will be stationed into station 1 (HDD), station 2 (Realtime Ultrasound) and station 3 (Dartfish Motion Analysis) Treatment they will receive* Blood flow restrictions cuff with physiotherapy exercises* Patient education Researcher will compare Blood flow exercises combined with physiotherapy exercises and education (Group A) with Physiotherapy exercises (Group B) to see if there is an effect on i) Pain ii) Muscle Functions (strength, muscle bulk, flexibility iii) Functional performance (anteromedial lunge, step-down, bilateral squat, balance, and reach) iv) Kinesiophobia v) Quality of life, conditionsModule conditions: Patellofemoral Pain Syndrome, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 128, type: ESTIMATED, armsInterventionsModule interventions name: Blood flow restriction combined with physiotherapy and education, outcomesModule primaryOutcomes measure: Numerical Pain Rating, primaryOutcomes measure: The Knee injury and Osteoarthritis Outcome Score for patellofemoral pain and osteoarthritis (KOOS-PF), primaryOutcomes measure: Tampa Scale, primaryOutcomes measure: Hand held dynamometer (HDD), primaryOutcomes measure: Knee Muscle performance Test with Dartfish software, primaryOutcomes measure: Real time ultrasounds, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 59 Years, stdAges: ADULT, contactsLocationsModule locations facility: Fakulti Sains Kesihatan, status: RECRUITING, city: Shah Alam, state: Selangor Darul Ehsan, zip: 42300, country: Malaysia, contacts name: Zarina Zahari, role: CONTACT, phone: 0132094170, email: zarinazahari@uitm.edu.my, contacts name: Nurul Atiqah Mohamed Mosbi, role: CONTACT, phone: 603-3258 4300, email: atiqahmosbi@uitm.edu.my, geoPoint lat: 3.08507, lon: 101.53281, hasResults: False