protocolSection identificationModule nctId: NCT06330961, orgStudyIdInfo id: 2023-MED-2756299, briefTitle: Effects of Different Kinds of Exercise in Low Back Pain, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-08, primaryCompletionDateStruct date: 2024-06, completionDateStruct date: 2025-02, studyFirstPostDateStruct date: 2024-03-26, lastUpdatePostDateStruct date: 2024-03-26, sponsorCollaboratorsModule leadSponsor name: University of Valencia, class: OTHER, descriptionModule briefSummary: Low back pain is considered one of the great global challenges in public health due to its high prevalence. Exercise have been shown to cause an increase in pain thresholds, through the effect known as exercise-induced hypoalgesia. Little is known about exercise-induced hypoalgesia induced by different modalities of exercise in low back pain, and its possible effects in lumbopelvic biomechanics.The goal of this clinical trial is to compare the effect of exercise-induced hypoalgesia after an isometric, aerobic and a sham/ placebo exercise in non-specific low back pain. The main questions it aims to answer are:* Does an isometric exercise intervention cause exercise-induced hypoalgesia in non-specific low back pain patients?* Is the effect of an isometric exercise intervention comparable to that of aerobic exercise?* Is a placebo/ sham intervention also effective to reduce pain thresholds in these patients?* Do healthy subjects show the same effects in pain thresholds as low back pain patients ? Participants will perform an isometric, aerobic and placebo/ sham exercise intervention in three different recording sessions. Before and after the interventions, pain intensity, pain-pressure thresholds and lumbopelvic biomechanical parameters during trunk flexion-extension will be recorded.Researchers will compare a group of low back pain patients to an age-, gender- and anthropometrics-matched control group of pain-free subjects to see if exercise-induced hypoalgesia is also observed when there is no low back pain diagnosis., conditionsModule conditions: Low Back Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 76, type: ESTIMATED, armsInterventionsModule interventions name: Isometric exercise, interventions name: Aerobic exercise, interventions name: Placebo intervention, outcomesModule primaryOutcomes measure: Pain intensity, primaryOutcomes measure: Pain-pressure thresholds, primaryOutcomes measure: Trunk flexion-extension electromyography (EMG), primaryOutcomes measure: Flexion-extension ratio (EMG), primaryOutcomes measure: Maximum ranges of lumbar and pelvic flexion, primaryOutcomes measure: Trunk flexion-extension percentages of motion, primaryOutcomes measure: Time of maximum flexion, primaryOutcomes measure: Fear-avoidance beliefs, primaryOutcomes measure: Pain distribution and supra-threshold stimulation, secondaryOutcomes measure: Anthropometric data: height, secondaryOutcomes measure: Anthropometric data: weight, secondaryOutcomes measure: Date of birth/ age, secondaryOutcomes measure: Sex/ gender, secondaryOutcomes measure: Basic clinical history and occupational data, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: Clinical Anatomy of the Musculoskeletal System Laboratory. Department of Anatomy and Human Embryology, School of Medicine, Universitat de València, status: RECRUITING, city: Valencia, zip: 46010, country: Spain, contacts name: Daniel Sánchez-Zuriaga, PhD, MD, role: CONTACT, phone: +343983522, phoneExt: 83522, email: daniel.sanchez@uv.es, geoPoint lat: 39.46975, lon: -0.37739, hasResults: False