protocolSection identificationModule nctId: NCT06335173, orgStudyIdInfo id: ACU193-201, secondaryIdInfos id: 2023-509807-34-00, type: REGISTRY, domain: EU CT Number, briefTitle: A Study to Evaluate Efficacy and Safety of Intravenous ACU193 in Participants With Early Alzheimer's Disease (ALTITUDE-AD), acronym: ALTITUDE-AD, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-29, primaryCompletionDateStruct date: 2031-01, completionDateStruct date: 2031-01, studyFirstPostDateStruct date: 2024-03-28, lastUpdatePostDateStruct date: 2024-03-29, sponsorCollaboratorsModule leadSponsor name: Acumen Pharmaceuticals, class: INDUSTRY, descriptionModule briefSummary: The primary purpose of this study is to evaluate the efficacy of ACU193 infusions administered once every four weeks (Q4W) in slowing cognitive and functional decline as compared to placebo in participants with early Alzheimer's disease., conditionsModule conditions: Alzheimer Disease, designModule studyType: INTERVENTIONAL, phases: PHASE2, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 2040, type: ESTIMATED, armsInterventionsModule interventions name: ACU193, interventions name: Placebo, outcomesModule primaryOutcomes measure: Change from Baseline in Integrated Alzheimer's Disease Rating Scale (iADRS) Score, secondaryOutcomes measure: Change from Baseline in ADCS-iADL Score, secondaryOutcomes measure: Change from Baseline in ADAS-Cog13 Score, secondaryOutcomes measure: Change from Baseline in Clinical Dementia Rating - Sum of Boxes (CDR-SB), secondaryOutcomes measure: Change from Baseline in Mini-Mental State Examination (MMSE), secondaryOutcomes measure: Change from Baseline in Quality of Life in Alzheimer's Disease (QoL-AD), secondaryOutcomes measure: Change from Baseline in Neuropsychiatric Inventory Questionnaire (NPI-Q) Score, secondaryOutcomes measure: Change from Baseline in EuroQoL 5-Dimension 5-Level (EQ-5D-5L), secondaryOutcomes measure: Change from Baseline in Resource Utilization in Dementia (RUD), secondaryOutcomes measure: Change from Baseline in Zarit Burden Interview (ZBI), secondaryOutcomes measure: Effect of ACU193 on Clinical Progression as Compared to Placebo Assessed Using Time Saved Analysis as Measured by iADRS, secondaryOutcomes measure: Effect of ACU193 on Clinical Progression as Compared to Placebo Assessed Using Time Saved Analysis as Measured by ADCS-iADL, secondaryOutcomes measure: Effect of ACU193 on Clinical Progression as Compared to Placebo Assessed Using Time Saved Analysis as Measured by ADAS-Cog13, secondaryOutcomes measure: Effect of ACU193 on Clinical Progression as Compared to Placebo Assessed Using Time Saved Analysis as Measured by CDR-SB, secondaryOutcomes measure: Effect of ACU193 on Clinical Progression as Compared to Placebo Assessed Using Time Saved Analysis as Measured by MMSE, secondaryOutcomes measure: Percentage of Participants with No Clinical Progression at One Year, secondaryOutcomes measure: Number of Participants with Treatment-Related Adverse Events (TEAEs), secondaryOutcomes measure: Number of Participants with Serious Adverse Events (SAEs) and Adverse Events of Special Interest (AESI), secondaryOutcomes measure: Number of Participants who Discontinue or Withdraw due to TEAE, secondaryOutcomes measure: Number of Participants with Anti-Drug Antibodies (ADA) and Neutralizing Antibodies, secondaryOutcomes measure: Number of Participants with Amyloid-Related Imaging Abnormality with Edema/Effusions (ARIA-E) and ARIA with Hemorrhage/Hemosiderin Deposition (ARIA-H) as Measured by Magnetic Resonance Imaging (MRI), secondaryOutcomes measure: Number of Participants with Suicidal Ideation and Behavior as Measured by Columbia-Suicide Severity Rating Scale (C-SSRS), secondaryOutcomes measure: Serum Concentration of ACU193, secondaryOutcomes measure: Concentration of ACU193 in Cerebrospinal Fluid (CSF), secondaryOutcomes measure: CSF Concentrations of ACU193 in a Subset of Participants, secondaryOutcomes measure: Correlation Between ACU193 Exposure with Clinical Efficacy Measures, secondaryOutcomes measure: Change From Baseline in Amyloid Plaque Load or Deposition Measured by Positron Emission Tomography (PET) in Centiloids, secondaryOutcomes measure: Change from Baseline in Volumetric Magnetic Resonance Imaging (vMRI) of Whole Brain Volume, Ventricular Volume, and Volume of Selected Regions of Interest, secondaryOutcomes measure: Target Engagement Assessed by Measurement of ACU193- Amyloid-β oligomer (AβO) Complex in CSF, secondaryOutcomes measure: Change from Baseline in CSF Concentrations of Amyloid, Tau and Other Neurodegenerative Biomarkers, secondaryOutcomes measure: Change from Baseline in CSF Concentrations of Amyloid, Tau, and Other Neurodegenerative Biomarkers in a Subset of Participants, secondaryOutcomes measure: Change from Baseline in Blood Concentrations of Amyloid, Tau, and Other Neurodegenerative Biomarkers, secondaryOutcomes measure: Correlation Between Change in Biomarker that Reflect Disease Progression and Clinical Changes, eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Banner Alzheimer's Institute- Clinical Trials Department, status: NOT_YET_RECRUITING, city: Phoenix, state: Arizona, zip: 85006, country: United States, geoPoint lat: 33.44838, lon: -112.07404, locations facility: IMA Clinical Research - Phoenix, status: NOT_YET_RECRUITING, city: Phoenix, state: Arizona, zip: 85012, country: United States, geoPoint lat: 33.44838, lon: -112.07404, locations facility: The Neurology Center of Southern California - Carlsbad, status: NOT_YET_RECRUITING, city: Carlsbad, state: California, zip: 92011-4219, country: United States, geoPoint lat: 33.15809, lon: -117.35059, locations facility: Neurology Center of North Orange County, status: NOT_YET_RECRUITING, city: Fullerton, state: California, zip: 92835, country: United States, geoPoint lat: 33.87029, lon: -117.92534, locations facility: Irvine Medical Research, status: NOT_YET_RECRUITING, city: Irvine, state: California, zip: 92614, country: United States, geoPoint lat: 33.66946, lon: -117.82311, locations facility: Healthy Brain Research, status: NOT_YET_RECRUITING, city: Long Beach, state: California, zip: 90804, country: United States, geoPoint lat: 33.76696, lon: -118.18923, locations facility: Sharp Mesa Vista Hospital, status: NOT_YET_RECRUITING, city: San Diego, state: California, zip: 92123, country: United States, geoPoint lat: 32.71533, lon: -117.15726, locations facility: Syrentis Clinical Research, status: NOT_YET_RECRUITING, city: Santa Ana, state: California, zip: 92705, country: United States, geoPoint lat: 33.74557, lon: -117.86783, locations facility: CenExel - California Neuroscience Research Medical Group, Inc (CNR), status: NOT_YET_RECRUITING, city: Sherman Oaks, state: California, zip: 91403-2131, country: United States, geoPoint lat: 34.15112, lon: -118.44925, locations facility: Alpine Clinical Research Center, status: NOT_YET_RECRUITING, city: Boulder, state: Colorado, zip: 80301-1880, country: United States, geoPoint lat: 40.01499, lon: -105.27055, locations facility: The Mile High Research Center, status: NOT_YET_RECRUITING, city: Denver, state: Colorado, zip: 80218, country: United States, geoPoint lat: 39.73915, lon: -104.9847, locations facility: Yale School of Medicine - Alzheimer's Disease Research Unit (ADRU), status: NOT_YET_RECRUITING, city: New Haven, state: Connecticut, zip: 06510-3330, country: United States, geoPoint lat: 41.30815, lon: -72.92816, locations facility: Research Center for Clinical Studies, LLC, status: NOT_YET_RECRUITING, city: Norwalk, state: Connecticut, zip: 06851-4903, country: United States, geoPoint lat: 41.1176, lon: -73.4079, locations facility: Re:Cognition Health - Fairfax, status: NOT_YET_RECRUITING, city: Washington, state: District of Columbia, zip: 22031, country: United States, geoPoint lat: 38.89511, lon: -77.03637, locations facility: JEM Research Institute, status: RECRUITING, city: Atlantis, state: Florida, zip: 33462, country: United States, contacts name: Clinical Research Coordinator, role: CONTACT, phone: 561-968-2933, email: research@jemri.net, geoPoint lat: 26.5909, lon: -80.10088, locations facility: Bradenton Research Center, status: NOT_YET_RECRUITING, city: Bradenton, state: Florida, zip: 34205, country: United States, geoPoint lat: 27.49893, lon: -82.57482, locations facility: Gil Fernandez-Yera, MD, PA, status: NOT_YET_RECRUITING, city: Coral Gables, state: Florida, zip: 33135, country: United States, geoPoint lat: 25.72149, lon: -80.26838, locations facility: Brain Matters Research, status: NOT_YET_RECRUITING, city: Delray Beach, state: Florida, zip: 33445, country: United States, geoPoint lat: 26.46146, lon: -80.07282, locations facility: Coral Clinical Research, status: NOT_YET_RECRUITING, city: Homestead, state: Florida, zip: 33032, country: United States, geoPoint lat: 25.46872, lon: -80.47756, locations facility: K2 Medical Research - Villages, status: RECRUITING, city: Lady Lake, state: Florida, zip: 32159, country: United States, contacts name: Kylie Webster, role: CONTACT, phone: 352-565-7524, email: kylie.webster@k2med.com, geoPoint lat: 28.91749, lon: -81.92286, locations facility: Verus Clinical Research, status: NOT_YET_RECRUITING, city: Miami, state: Florida, zip: 33125, country: United States, geoPoint lat: 25.77427, lon: -80.19366, locations facility: Finlay Medical Research, status: NOT_YET_RECRUITING, city: Miami, state: Florida, zip: 33126, country: United States, geoPoint lat: 25.77427, lon: -80.19366, locations facility: Collier Neurologic Specialists (CNS), L.L.C., status: NOT_YET_RECRUITING, city: Naples, state: Florida, zip: 34105-8522, country: United States, geoPoint lat: 26.14234, lon: -81.79596, locations facility: Ocala Health - Family Care Specialists - Ocala I, status: NOT_YET_RECRUITING, city: Ocala, state: Florida, zip: 34470, country: United States, geoPoint lat: 29.1872, lon: -82.14009, locations facility: Progressive Medical Research, status: NOT_YET_RECRUITING, city: Port Orange, state: Florida, zip: 32127, country: United States, geoPoint lat: 29.13832, lon: -80.99561, locations facility: Alzheimer's Research and Treatment Center - Stuart, status: NOT_YET_RECRUITING, city: Stuart, state: Florida, zip: 34997, country: United States, geoPoint lat: 27.19755, lon: -80.25283, locations facility: K2 Medical Research - Tampa, status: NOT_YET_RECRUITING, city: Tampa, state: Florida, zip: 33607, country: United States, geoPoint lat: 27.94752, lon: -82.45843, locations facility: Charter Research - Lady Lake, status: RECRUITING, city: The Villages, state: Florida, zip: 32162, country: United States, contacts name: Brittany Ortiz, role: CONTACT, phone: 352-775-1000, email: brittany.ortiz@charterresearch.com, geoPoint lat: 28.93408, lon: -81.95994, locations facility: Alzheimers Research and Treatment Center - Wellington, status: NOT_YET_RECRUITING, city: Wellington, state: Florida, zip: 33414, country: United States, geoPoint lat: 26.65868, lon: -80.24144, locations facility: Conquest Research, status: RECRUITING, city: Winter Park, state: Florida, zip: 32789, country: United States, contacts name: Elizabeth Schneider, role: CONTACT, phone: 689-488-9113, email: elizabeth.schneider@ConquestResearch.com, geoPoint lat: 28.6, lon: -81.33924, locations facility: Charter Research - Winter Park, status: NOT_YET_RECRUITING, city: Winter Park, state: Florida, zip: 32792, country: United States, geoPoint lat: 28.6, lon: -81.33924, locations facility: Columbus Memory Center, status: NOT_YET_RECRUITING, city: Columbus, state: Georgia, zip: 31909, country: United States, geoPoint lat: 32.46098, lon: -84.98771, locations facility: Accel Research- Neurostudies, status: NOT_YET_RECRUITING, city: Decatur, state: Georgia, zip: 30030, country: United States, geoPoint lat: 33.77483, lon: -84.29631, locations facility: CenExel - iResearch Atlanta, status: NOT_YET_RECRUITING, city: Decatur, state: Georgia, zip: 30030, country: United States, geoPoint lat: 33.77483, lon: -84.29631, locations facility: CenExel - iResearch Savannah, status: NOT_YET_RECRUITING, city: Savannah, state: Georgia, zip: 31405, country: United States, geoPoint lat: 32.08354, lon: -81.09983, locations facility: Office of Jeffrey S. Ross, MD, status: NOT_YET_RECRUITING, city: Northbrook, state: Illinois, zip: 60640, country: United States, geoPoint lat: 42.12753, lon: -87.82895, locations facility: KU Wichita Center for Clinical Research, status: NOT_YET_RECRUITING, city: Wichita, state: Kansas, zip: 67214, country: United States, geoPoint lat: 37.69224, lon: -97.33754, locations facility: ActivMed Practices and Research, status: NOT_YET_RECRUITING, city: Methuen, state: Massachusetts, zip: 03801, country: United States, geoPoint lat: 42.7262, lon: -71.19089, locations facility: Boston Center for Memory, status: NOT_YET_RECRUITING, city: Newton, state: Massachusetts, zip: 02459, country: United States, geoPoint lat: 42.33704, lon: -71.20922, locations facility: Donald S. Marks, MD. P.C., status: NOT_YET_RECRUITING, city: Plymouth, state: Massachusetts, zip: 02360, country: United States, geoPoint lat: 41.95844, lon: -70.66726, locations facility: Hattiesburg Clinic - Memory Center, status: NOT_YET_RECRUITING, city: Hattiesburg, state: Mississippi, zip: 39401-7246, country: United States, geoPoint lat: 31.32712, lon: -89.29034, locations facility: Las Vegas Medical Research Center, status: NOT_YET_RECRUITING, city: Las Vegas, state: Nevada, zip: 89113-2215, country: United States, geoPoint lat: 36.17497, lon: -115.13722, locations facility: Princeton Psychiatric Center, status: NOT_YET_RECRUITING, city: Princeton, state: New Jersey, zip: 08540-2859, country: United States, geoPoint lat: 40.34872, lon: -74.65905, locations facility: The Cognitive and Research Center of New Jersey, status: NOT_YET_RECRUITING, city: Springfield, state: New Jersey, zip: 07081, country: United States, geoPoint lat: 40.70491, lon: -74.31723, locations facility: CenExel - Advanced Memory Research Institute of NJ, status: RECRUITING, city: Toms River, state: New Jersey, zip: 08755, country: United States, contacts name: Anna Anna Brocco, role: CONTACT, phone: 732-341-9500, phoneExt: 3510, email: amri.recruitment@cenexel.com, geoPoint lat: 39.95373, lon: -74.19792, locations facility: IMA Clinical Research - Albuquerque, status: NOT_YET_RECRUITING, city: Albuquerque, state: New Mexico, zip: 87109, country: United States, geoPoint lat: 35.08449, lon: -106.65114, locations facility: Neurological Associates of Albany, status: NOT_YET_RECRUITING, city: Albany, state: New York, zip: 12208, country: United States, geoPoint lat: 42.65258, lon: -73.75623, locations facility: Neurological Institute of New York, status: NOT_YET_RECRUITING, city: New York, state: New York, zip: 10032, country: United States, geoPoint lat: 40.71427, lon: -74.00597, locations facility: SUNY Upstate Medical University - Upstate University Hospital (SUNY Health Science Center), status: NOT_YET_RECRUITING, city: Syracuse, state: New York, zip: 13210-2342, country: United States, geoPoint lat: 43.04812, lon: -76.14742, locations facility: AMC Research, status: NOT_YET_RECRUITING, city: Matthews, state: North Carolina, zip: 28105, country: United States, geoPoint lat: 35.11681, lon: -80.72368, locations facility: Cleveland Clinic - Lou Ruvo Center for Brain Health (CCLRCBH), status: NOT_YET_RECRUITING, city: Lakewood, state: Ohio, zip: 44107, country: United States, geoPoint lat: 41.48199, lon: -81.79819, locations facility: Summit Research Network, status: NOT_YET_RECRUITING, city: Portland, state: Oregon, zip: 97210, country: United States, geoPoint lat: 45.52345, lon: -122.67621, locations facility: Abington Neurological Associates, status: NOT_YET_RECRUITING, city: Abington, state: Pennsylvania, zip: 19001, country: United States, geoPoint lat: 40.12067, lon: -75.11795, locations facility: Keystone Clinical Research, status: RECRUITING, city: Norristown, state: Pennsylvania, zip: 19462, country: United States, contacts name: Cherian Verghese, role: CONTACT, phone: 610-277-8073, email: CVerghese@flourishresearch.com, geoPoint lat: 40.1215, lon: -75.3399, locations facility: Rhode Island Mood and Memory, status: NOT_YET_RECRUITING, city: East Providence, state: Rhode Island, zip: 02914, country: United States, geoPoint lat: 41.81371, lon: -71.37005, locations facility: Neurology Clinic. P.C, status: NOT_YET_RECRUITING, city: Cordova, state: Tennessee, zip: 38018, country: United States, geoPoint lat: 35.15565, lon: -89.7762, locations facility: The Alliance for Multispecialty Research LLC (AMR) - Knoxville (Volunteer Research Group), status: NOT_YET_RECRUITING, city: Knoxville, state: Tennessee, zip: 37920-1511, country: United States, geoPoint lat: 35.96064, lon: -83.92074, locations facility: Senior Adult Specialty Research, status: NOT_YET_RECRUITING, city: Austin, state: Texas, zip: 78757, country: United States, geoPoint lat: 30.26715, lon: -97.74306, locations facility: Gadolin Research, LLC, status: NOT_YET_RECRUITING, city: Beaumont, state: Texas, zip: 77702, country: United States, geoPoint lat: 30.08605, lon: -94.10185, locations facility: Kerwin Medical Center, status: NOT_YET_RECRUITING, city: Dallas, state: Texas, zip: 75231, country: United States, geoPoint lat: 32.78306, lon: -96.80667, locations facility: Okanagan Clinical Trials, status: NOT_YET_RECRUITING, city: Kelowna, state: British Columbia, country: Canada, geoPoint lat: 49.88307, lon: -119.48568, locations facility: Office of Alexandre Henri-Bhargava, MD, status: NOT_YET_RECRUITING, city: Victoria, state: British Columbia, country: Canada, geoPoint lat: 48.43294, lon: -123.3693, locations facility: Parkwood Institute, status: NOT_YET_RECRUITING, city: London, state: Ontario, country: Canada, geoPoint lat: 42.98339, lon: -81.23304, locations facility: Hippocampe d/b/a Ottawa Memory Clinic, status: NOT_YET_RECRUITING, city: Ottawa, state: Ontario, country: Canada, geoPoint lat: 45.41117, lon: -75.69812, locations facility: The Kawartha Regional Memory Clinic (KRMC), status: NOT_YET_RECRUITING, city: Peterborough, state: Ontario, country: Canada, geoPoint lat: 44.30012, lon: -78.31623, locations facility: Baycrest - The Rotman Research Institute (RRI), status: NOT_YET_RECRUITING, city: Toronto, state: Ontario, country: Canada, geoPoint lat: 43.70011, lon: -79.4163, locations facility: Toronto Memory Program (TMP) (Neurology Research Inc.), status: NOT_YET_RECRUITING, city: Toronto, state: Ontario, country: Canada, geoPoint lat: 43.70011, lon: -79.4163, locations facility: University Health Network (UHN) - Toronto Western Hospital (TWH) - Krembil Neuroscience Centre (KNC) - Memory Clinic, status: NOT_YET_RECRUITING, city: Toronto, state: Ontario, country: Canada, geoPoint lat: 43.70011, lon: -79.4163, locations facility: MoCA Research and Innovations, status: NOT_YET_RECRUITING, city: Greenfield Park, state: Quebec, country: Canada, geoPoint lat: 45.48649, lon: -73.46223, locations facility: Amiens university hospital, status: NOT_YET_RECRUITING, city: Amiens, country: France, geoPoint lat: 49.9, lon: 2.3, locations facility: Chu Pellegrin, status: NOT_YET_RECRUITING, city: Bordeaux, country: France, geoPoint lat: 44.84044, lon: -0.5805, locations facility: Hopital Neurologique Pierre Wertheimer, status: NOT_YET_RECRUITING, city: Bron, country: France, geoPoint lat: 45.73333, lon: 4.91667, locations facility: Hôpital de la Timone, status: NOT_YET_RECRUITING, city: Marseille Cedex 05, country: France, geoPoint lat: 43.29551, lon: 5.38958, locations facility: Chu Montpellier, status: NOT_YET_RECRUITING, city: Montpellier, country: France, geoPoint lat: 43.61092, lon: 3.87723, locations facility: Hopital Lariboisiere, status: NOT_YET_RECRUITING, city: Paris, country: France, geoPoint lat: 48.85341, lon: 2.3488, locations facility: Institut de la Mémoire et de la Maladie d'Alzheimer -IM2A, status: NOT_YET_RECRUITING, city: Paris, country: France, geoPoint lat: 48.85341, lon: 2.3488, locations facility: CHU de Rennes, CMRR, status: NOT_YET_RECRUITING, city: Rennes, country: France, geoPoint lat: 48.11198, lon: -1.67429, locations facility: CHU de NANTES-Hôpital Nord Laennec, status: NOT_YET_RECRUITING, city: Saint-Herblain, country: France, geoPoint lat: 47.21765, lon: -1.64841, locations facility: Hôpitaux Universitaires de Strasbourg, status: NOT_YET_RECRUITING, city: Strasbourg, country: France, geoPoint lat: 48.58392, lon: 7.74553, locations facility: Centre de Recherche du Gérontopôle - CHU de Toulouse Hôpital la Grave, status: NOT_YET_RECRUITING, city: Toulouse, country: France, geoPoint lat: 43.60426, lon: 1.44367, locations facility: Charité - Universitaetsmedizin Berlin, status: NOT_YET_RECRUITING, city: Berlin, country: Germany, geoPoint lat: 52.52437, lon: 13.41053, locations facility: Pharmakologisches Studienzentrum Chemnitz GmbH, status: NOT_YET_RECRUITING, city: Chemnitz, country: Germany, geoPoint lat: 50.8357, lon: 12.92922, locations facility: University Hospital of Cologne, status: NOT_YET_RECRUITING, city: Cologne, country: Germany, geoPoint lat: 50.93333, lon: 6.95, locations facility: Saarland University Hospital, status: NOT_YET_RECRUITING, city: Homburg, country: Germany, geoPoint lat: 49.32637, lon: 7.33867, locations facility: Zentralinstitut für seelische Gesundheit, status: NOT_YET_RECRUITING, city: Mannheim, country: Germany, geoPoint lat: 49.4891, lon: 8.46694, locations facility: Technical University of Munich, School of Medicine and Health, Klinikum rechts der Isar, status: NOT_YET_RECRUITING, city: Munich, country: Germany, geoPoint lat: 48.13743, lon: 11.57549, locations facility: Rostock University Medical Center, status: NOT_YET_RECRUITING, city: Rostock, country: Germany, geoPoint lat: 54.0887, lon: 12.14049, locations facility: Praxisgemeinschaft Dr. Springub/Schwarz, status: NOT_YET_RECRUITING, city: Westerstede, country: Germany, geoPoint lat: 53.25682, lon: 7.92737, locations facility: Fondazione Istituto G. Giglio di Cefalù, status: NOT_YET_RECRUITING, city: Cefalù, country: Italy, geoPoint lat: 38.03856, lon: 14.02285, locations facility: Policlinico San Martino, status: NOT_YET_RECRUITING, city: Genova, country: Italy, geoPoint lat: 44.40478, lon: 8.94438, locations facility: Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, status: NOT_YET_RECRUITING, city: Milano, country: Italy, geoPoint lat: 45.46427, lon: 9.18951, locations facility: Fondazione IRCCS San Gerardo dei Tintori, status: NOT_YET_RECRUITING, city: Monza, country: Italy, geoPoint lat: 45.58005, lon: 9.27246, locations facility: Neurology Clinic, status: NOT_YET_RECRUITING, city: Perugia, country: Italy, geoPoint lat: 43.1122, lon: 12.38878, locations facility: IRCCS Neuromed, status: NOT_YET_RECRUITING, city: Pozzilli, country: Italy, geoPoint lat: 41.51142, lon: 14.06252, locations facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS, status: NOT_YET_RECRUITING, city: Roma, country: Italy, geoPoint lat: 41.89193, lon: 12.51133, locations facility: Sapienza Università di Roma - AOU Policlinico Umberto I, status: NOT_YET_RECRUITING, city: Roma, country: Italy, geoPoint lat: 41.89193, lon: 12.51133, locations facility: SSD Alzheimer's disease and related dementias, status: NOT_YET_RECRUITING, city: Torino, country: Italy, geoPoint lat: 45.07049, lon: 7.68682, locations facility: A.O. Piafondazione Card. G. Panico, status: NOT_YET_RECRUITING, city: Tricase, country: Italy, geoPoint lat: 39.93018, lon: 18.35421, locations facility: Centrum Medyczne Neuromed, status: NOT_YET_RECRUITING, city: Bydgoszcz, country: Poland, geoPoint lat: 53.1235, lon: 18.00762, locations facility: Krakowska Akademia Neurologii Sp. z o.o., status: NOT_YET_RECRUITING, city: Krakow, country: Poland, geoPoint lat: 50.06143, lon: 19.93658, locations facility: NZOZ Syntonia, status: NOT_YET_RECRUITING, city: Pruszcz Gdanski, country: Poland, geoPoint lat: 54.26217, lon: 18.63625, locations facility: RCMed, status: NOT_YET_RECRUITING, city: Sochaczew, country: Poland, geoPoint lat: 52.22944, lon: 20.23838, locations facility: Centrum Medyczne Senior, status: NOT_YET_RECRUITING, city: Sopot, country: Poland, geoPoint lat: 54.4418, lon: 18.56003, locations facility: Centrum Medyczne NeuroProtect, status: NOT_YET_RECRUITING, city: Warsaw, country: Poland, geoPoint lat: 52.22977, lon: 21.01178, locations facility: Hospital Universitari General de catalunya, status: NOT_YET_RECRUITING, city: Sant Cugat Del Vallès, state: Barcelona, country: Spain, geoPoint lat: 41.47063, lon: 2.08611, locations facility: Fundacion CITA alzheimer, status: NOT_YET_RECRUITING, city: San Sebastián, state: Gipuzkoa, country: Spain, geoPoint lat: 43.31283, lon: -1.97499, locations facility: Fundacion Neuropolis - Hospital Viamed Montecanal, status: NOT_YET_RECRUITING, city: Cuarte de Huerva, state: Zaragoza, country: Spain, geoPoint lat: 41.59466, lon: -0.93268, locations facility: Fundacio ACE, status: NOT_YET_RECRUITING, city: Barcelona, country: Spain, geoPoint lat: 41.38879, lon: 2.15899, locations facility: Hospital Universitario Reina Sofia, status: NOT_YET_RECRUITING, city: Cordoba, country: Spain, geoPoint lat: 37.89155, lon: -4.77275, locations facility: Cae Oroitu, status: NOT_YET_RECRUITING, city: Getxo, country: Spain, geoPoint lat: 43.35689, lon: -3.01146, locations facility: Hospital Ruber, status: NOT_YET_RECRUITING, city: Madrid, country: Spain, geoPoint lat: 40.4165, lon: -3.70256, locations facility: Policlínica Gipuzkoa, status: NOT_YET_RECRUITING, city: San Sebastian, country: Spain, geoPoint lat: 43.31283, lon: -1.97499, locations facility: Hospital Victoria Eugenia, status: NOT_YET_RECRUITING, city: Sevilla, country: Spain, geoPoint lat: 37.38283, lon: -5.97317, locations facility: Hospital Universitari i Politècnic La Fe, status: NOT_YET_RECRUITING, city: Valencia, country: Spain, geoPoint lat: 39.46975, lon: -0.37739, locations facility: Re:Cognition Health - Plymouth, status: NOT_YET_RECRUITING, city: Plymouth, state: Devon, country: United Kingdom, geoPoint lat: 50.37153, lon: -4.14305, locations facility: Panthera Biopartners - Enfield, status: NOT_YET_RECRUITING, city: Enfield Town, state: Greater London, country: United Kingdom, geoPoint lat: 51.65147, lon: -0.08497, locations facility: Re:Cognition Health - London, status: NOT_YET_RECRUITING, city: London, state: Greater London, country: United Kingdom, geoPoint lat: 51.50853, lon: -0.12574, locations facility: St. Pancras Clinical Research Ltd., status: NOT_YET_RECRUITING, city: London, state: Greater London, country: United Kingdom, geoPoint lat: 51.50853, lon: -0.12574, locations facility: Panthera Bio-Partners - Rochdale, status: NOT_YET_RECRUITING, city: Rochdale, state: Greater Manchester, country: United Kingdom, geoPoint lat: 53.61766, lon: -2.1552, locations facility: Re:Cognition Health - Winchester, status: NOT_YET_RECRUITING, city: Winchester, state: Hampshire, country: United Kingdom, geoPoint lat: 51.06513, lon: -1.3187, locations facility: Neuroclin Glasgow, status: NOT_YET_RECRUITING, city: Motherwell, state: Lanarkshire, country: United Kingdom, geoPoint lat: 55.78924, lon: -3.99187, locations facility: Panthera Bio-Partners - Preston, status: NOT_YET_RECRUITING, city: Preston, state: Lancashire, country: United Kingdom, geoPoint lat: 53.76282, lon: -2.70452, locations facility: Re:Cognition Health - Guildford, status: NOT_YET_RECRUITING, city: Guildford, state: Surrey, country: United Kingdom, geoPoint lat: 51.23536, lon: -0.57427, locations facility: Re:Cognition Health - Birmingham, status: NOT_YET_RECRUITING, city: Birmingham, state: West Midlands, country: United Kingdom, geoPoint lat: 52.48142, lon: -1.89983, locations facility: Panthera Biopartners - Sheffield, status: NOT_YET_RECRUITING, city: Sheffield, state: Yorkshire, country: United Kingdom, geoPoint lat: 53.38297, lon: -1.4659, locations facility: Re:Cognition Health - Bristol, status: NOT_YET_RECRUITING, city: Bristol, country: United Kingdom, geoPoint lat: 51.45523, lon: -2.59665, hasResults: False