hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06296563, orgStudyIdInfo id: SHR1316-ICC-SD-001, briefTitle: Perioperative Treatment of Resectable Intrahepatic Cholangiocarcinoma With the Combination of Adebrelimab and Apatinib and HAIC, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2027-03-01, completionDateStruct date: 2029-03-01, studyFirstPostDateStruct date: 2024-03-06, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Lei ZHAO, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to explore the efficacy and safety of combined infusion chemotherapy with Adebrelimab and Apatinib in the perioperative treatment of resectable intrahepatic cholangiocarcinoma patients. The main question it aims to answer are:How to improve the survival of patients with intrahepatic cholangiocarcinoma and prolong the recurrence time after surgery.Participants will receive receive neoadjuvant therapy with Adebrelimab combined with apatinib and FOLFOX-HAIC for 2 cycles (1 treatment cycle every 21 days, apatinib only used for the first cycle), and surgery was performed 14-28 days after the end of treatment. After 28 days of surgery, patients will continue to receive adjuvant treatment with Adebrelimab combined with apatinib for a maximum of one year., conditionsModule conditions: Intrahepatic Cholangiocarcinoma, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: HAIC, interventions name: Adebrelimab, interventions name: Apatinib, outcomesModule primaryOutcomes measure: Pathologic complete response (pCR), secondaryOutcomes measure: Objective response rate (ORR), secondaryOutcomes measure: Event free survival (EFS), secondaryOutcomes measure: Overall Survival (OS), secondaryOutcomes measure: Disease Control Rate (DCR), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Shandong Cancer Hospital and Institute, status: RECRUITING, city: Jinan, state: Shandong, zip: 250117, country: China, contacts name: Lei Zhao, MD, role: CONTACT, phone: +86 053167626368, email: drzhaolei@hotmail.com, contacts name: Peifei Sun, MD, role: CONTACT, phone: +86 053167626242, contacts name: Lei Zhao, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 36.66833, lon: 116.99722, hasResults: False
protocolSection identificationModule nctId: NCT06296550, orgStudyIdInfo id: Dulce Digital CGM, briefTitle: Enhancing Digitally Delivered Diabetes Education With Real-Time CGM, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2026-04-30, completionDateStruct date: 2026-04-30, studyFirstPostDateStruct date: 2024-03-06, lastUpdatePostDateStruct date: 2024-03-06, sponsorCollaboratorsModule leadSponsor name: Scripps Whittier Diabetes Institute, class: OTHER, descriptionModule briefSummary: The current research study will add continuous glucose monitoring devices to the evidence-based text messaging diabetes education program for patients with type 2 diabetes for 6 months. Results on the effectiveness of this intervention will be compared for non-insulin using patients., conditionsModule conditions: Diabetes Type 2, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 140, type: ESTIMATED, armsInterventionsModule interventions name: Dulce Digital Text Messaging Intervention, interventions name: CGM Device, outcomesModule primaryOutcomes measure: HbA1c, secondaryOutcomes measure: CGM Metric Time in Range, secondaryOutcomes measure: CGM Metric Time above Range, secondaryOutcomes measure: CGM Metric Time Below Range, secondaryOutcomes measure: Summary of Diabetes Self Care Activitiers (SDSCA) Survey, secondaryOutcomes measure: Diabetes Distress Scale, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Scripps Whittier Diabetes Institute, city: San Diego, state: California, zip: 92121-1520, country: United States, contacts name: Athena Philis-Tsimikas, MD, role: CONTACT, phone: 858-729-4830, email: tsimikas.athena@scrippshealth.org, contacts name: Kallie Brown, MA, role: CONTACT, phone: 858-678-6294, email: brown.kallie@scrippshealth.org, geoPoint lat: 32.71533, lon: -117.15726, hasResults: False
protocolSection identificationModule nctId: NCT06296524, orgStudyIdInfo id: SPC-2022-09, briefTitle: Effect of Footcore Exercises on Navicular Drop and Plantar Pressure Distribution in Asymptomatic Individual With Flatfoot, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2024-03-01, completionDateStruct date: 2024-03-30, studyFirstPostDateStruct date: 2024-03-06, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Maharishi Markendeswar University (Deemed to be University), class: OTHER, descriptionModule briefSummary: Pes Planus is a medical condition in which arch of the foot is flattened, causing the entire sole of the foot to contact the floor. For those with flat feet, footcore exercises might be an effective non-invasive therapy. Footcore exercises aim to strengthen the intrinsic foot muscles that maintain the foot arch, enhance foot function and reduce the risk of injury in persons with flatfoot., conditionsModule conditions: Flatfoot, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule interventions name: Footcore exercises and conventional therapy, interventions name: conventional therapy, outcomesModule primaryOutcomes measure: Navicular Drop Test, primaryOutcomes measure: Harris Mat for Plantar Pressure Distribution, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 30 Years, stdAges: ADULT, contactsLocationsModule locations facility: MMIPR, status: RECRUITING, city: Ambala, state: Haryana, zip: 133207, country: India, contacts name: Mousumi Saha, MPT, role: CONTACT, phone: +919366787310, email: msaha0029@gmail.com, contacts name: subhasish chatterjee, Phd(NEURO), role: CONTACT, phone: +918950037407, email: subhasishphysio@gmail.com, contacts name: subhasish chatterjee, Phd, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.36099, lon: 76.79782, hasResults: False
protocolSection identificationModule nctId: NCT06296511, orgStudyIdInfo id: Loughborough University, briefTitle: The Influence of Acute Moderate-intensity Continuous Exercise on Appetite Regulation, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-06-23, primaryCompletionDateStruct date: 2023-11-07, completionDateStruct date: 2023-11-07, studyFirstPostDateStruct date: 2024-03-06, lastUpdatePostDateStruct date: 2024-03-06, sponsorCollaboratorsModule leadSponsor name: Loughborough University, class: OTHER, descriptionModule briefSummary: A key area of obesity research has focused on the link between appetite, energy balance and weight control. Within this area, several appetite-related hormones and cellular cytokines have been identified as key signals influencing appetite and food intake. This includes the appetite-suppressing hormone oxyntomodulin (OXM) and a cellular stress-induced cytokine growth differentiation factor 15 (GDF-15).The aims of this study are: (1) to investigate the effect of acute moderate-intensity continuous exercise on oxyntomodulin and GDF-15 concentrations; (2) to investigate whether exercise-induced changes in circulating OXM and GDF-15 concentrations are correlated with subjective appetite perceptions and subsequent energy intake., conditionsModule conditions: Obesity, conditions: Overweight, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ACTUAL, armsInterventionsModule interventions name: Exercise, outcomesModule primaryOutcomes measure: Oxyntomodulin, primaryOutcomes measure: Growth Differentiation Factor 15, secondaryOutcomes measure: Visual analogue score (VAS) for subjective appetite, secondaryOutcomes measure: Energy intake, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule locations facility: Loughborough University, city: Loughborough, zip: LE11 3TU, country: United Kingdom, geoPoint lat: 52.76667, lon: -1.2, hasResults: False
protocolSection identificationModule nctId: NCT06296498, orgStudyIdInfo id: 20230505HU, briefTitle: Application of L-PRF in Periodontal Surgery, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-08-19, primaryCompletionDateStruct date: 2025-12, completionDateStruct date: 2026-03, studyFirstPostDateStruct date: 2024-03-06, lastUpdatePostDateStruct date: 2024-03-06, sponsorCollaboratorsModule leadSponsor name: The University of Texas Health Science Center at San Antonio, class: OTHER, descriptionModule briefSummary: The study will compare the clinical outcomes of the two procedures, open flap debridement (OFD) compared to open flap debridement with leukocyte and platelet-rich fibrin (L-PFR) as well as differences in patient postoperative pain perception., conditionsModule conditions: Periodontal Diseases, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: The proposed study is a split-mouth design, randomized, prospective clinical trial in which we will use either OFD alone or OFD + L-PRF for periodontal surgery. Both procedures are standard of care, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: Participants will be blinded to the intervention which they are randomized to., whoMasked: PARTICIPANT, enrollmentInfo count: 32, type: ESTIMATED, armsInterventionsModule interventions name: Leukocyte Platelet-rich fibrin, interventions name: Standard of care OFD, outcomesModule primaryOutcomes measure: Probing depth, primaryOutcomes measure: Postoperative Pain (PROM), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 89 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The University of Texas Health Science Center at San Antonio, status: RECRUITING, city: San Antonio, state: Texas, zip: 78229, country: United States, contacts name: Charles Powell, DDS, MS, role: CONTACT, phone: 210-567-3593, email: powellc2@uthscsa.edu, geoPoint lat: 29.42412, lon: -98.49363, hasResults: False
protocolSection identificationModule nctId: NCT06296485, orgStudyIdInfo id: IRB-1996616, secondaryIdInfos id: R01DK134446, type: NIH, link: https://reporter.nih.gov/quickSearch/R01DK134446, briefTitle: Safer Aging With Diabetes Monitoring, acronym: SAGE, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-30, primaryCompletionDateStruct date: 2027-03-30, completionDateStruct date: 2028-01-31, studyFirstPostDateStruct date: 2024-03-06, lastUpdatePostDateStruct date: 2024-03-06, sponsorCollaboratorsModule leadSponsor name: Kaiser Permanente, class: OTHER, collaborators name: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), descriptionModule briefSummary: Older adults with type 2 diabetes are at higher risk for severe hypoglycemia and its related complications (including hospitalization and death) when taking insulin. This study proposes to evaluate, in a randomized clinical trial, a strategy of safe insulin prescribing based on an educational program that leverages continuous glucose monitoring to support older adults at high risk for hypoglycemia. If the aims of this project are achieved, this novel care strategy could be widely applied to reduce severe hypoglycemia episodes in older, high-risk adults with type 2 diabetes., conditionsModule conditions: Diabetes Mellitus, Type 2, conditions: Hypoglycemia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: 3-arm pragmatic randomized clinical trial, primaryPurpose: PREVENTION, maskingInfo masking: SINGLE, maskingDescription: Participant randomization status will be masked during data collection (baseline and follow-up surveys) by research assistants, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 360, type: ESTIMATED, armsInterventionsModule interventions name: SAGE Group Sessions, interventions name: SAGE Group Sessions + Diabetes Pharmacist, interventions name: Usual Care, outcomesModule primaryOutcomes measure: Hypoglycemia aggregate outcome, secondaryOutcomes measure: Self-reported hypoglycemia, secondaryOutcomes measure: Hypoglycemia-related utilization, secondaryOutcomes measure: Diabetes Distress, secondaryOutcomes measure: Hypoglycemia Confidence, secondaryOutcomes measure: Hypoglycemia Distress, otherOutcomes measure: Technology Proficiency, otherOutcomes measure: Confidence in Adjusting Insulin, otherOutcomes measure: Insulin Adjustment, otherOutcomes measure: Caregiver Action, eligibilityModule sex: ALL, minimumAge: 75 Years, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06296472, orgStudyIdInfo id: MDQ23, briefTitle: De Quervain's Disease in the Acute Phase:a Study Aimed at Evaluating the Effectiveness of Standard Physiotherapy Treatment (HANDGUIDE), Compared to Experimental Treatment After Performing Ultrasound-guided Infiltrative Therapy., statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-27, primaryCompletionDateStruct date: 2025-02-01, completionDateStruct date: 2025-12-30, studyFirstPostDateStruct date: 2024-03-06, lastUpdatePostDateStruct date: 2024-03-06, sponsorCollaboratorsModule leadSponsor name: Istituto Ortopedico Rizzoli, class: OTHER, descriptionModule briefSummary: The objective of the study is to compare pain reduction and disability reduction in two groups of patients diagnosed with de Quervain syndrome who will undergo ultrasound-guided infiltrative treatment with corticosteroid as per normal clinical practice:* the control group will subsequently be subjected to a standard treatment based on the European guidelines of the HANDGUIDE group,* the experimental group will subsequently carry out a program of eccentric exercises., conditionsModule conditions: De Quervain Disease, conditions: Hand Tenosynovitis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: INVESTIGATOR, enrollmentInfo count: 134, type: ESTIMATED, armsInterventionsModule interventions name: Rehabilitation, interventions name: Standard, outcomesModule primaryOutcomes measure: Numeric Pain Rating Scale, primaryOutcomes measure: Numeric Pain Rating Scale, primaryOutcomes measure: Numeric Pain Rating Scale, primaryOutcomes measure: Numeric Pain Rating Scale, secondaryOutcomes measure: Disabilities of Arm, Shoulder and Hand, secondaryOutcomes measure: Disabilities of Arm, Shoulder and Hand, secondaryOutcomes measure: Disabilities of Arm, Shoulder and Hand, secondaryOutcomes measure: Disabilities of Arm, Shoulder and Hand, secondaryOutcomes measure: Patient-Rated Wrist Evaluation, secondaryOutcomes measure: Patient-Rated Wrist Evaluation, secondaryOutcomes measure: Patient-Rated Wrist Evaluation, secondaryOutcomes measure: Patient-Rated Wrist Evaluation, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Istituto Ortopedico Rizzoli, status: RECRUITING, city: Bologna, zip: 40136, country: Italy, contacts name: Fabio Vita, MD, role: CONTACT, email: fabio..vita@ior.it, geoPoint lat: 44.49381, lon: 11.33875, hasResults: False
protocolSection identificationModule nctId: NCT06296459, orgStudyIdInfo id: 20220556HU, briefTitle: Radiographic Changes in the Maxillary Sinus Following Closed Sinus Augmentation, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-09-21, primaryCompletionDateStruct date: 2024-12, completionDateStruct date: 2025-03, studyFirstPostDateStruct date: 2024-03-06, lastUpdatePostDateStruct date: 2024-03-06, sponsorCollaboratorsModule leadSponsor name: The University of Texas Health Science Center at San Antonio, class: OTHER, descriptionModule briefSummary: A closed sinus augmentation is performed for dental implant placement., conditionsModule conditions: Dental Implant, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: A 2 arm study using two methods of imaging in a participant, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 22, type: ESTIMATED, armsInterventionsModule interventions name: 3D R100 scanner, interventions name: Conventional Radiograph, outcomesModule primaryOutcomes measure: Dimensional Change in augmentation at 8mm, primaryOutcomes measure: Dimensional Change in augmentation at 10mm, primaryOutcomes measure: Dimensional Change in augmentation at 12mm, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 85 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The University of Texas Health Science Center at San Antonio, status: RECRUITING, city: San Antonio, state: Texas, zip: 78229, country: United States, contacts name: Charles Powell, DDS, MS, role: CONTACT, phone: 210-567-3593, email: powellc2@uthscsa.edu, geoPoint lat: 29.42412, lon: -98.49363, hasResults: False
protocolSection identificationModule nctId: NCT06296446, orgStudyIdInfo id: disability fibromyalgia, briefTitle: Disability of People With Fibromyalgia in Poland, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-15, primaryCompletionDateStruct date: 2024-05-01, completionDateStruct date: 2024-11-01, studyFirstPostDateStruct date: 2024-03-06, lastUpdatePostDateStruct date: 2024-04-16, sponsorCollaboratorsModule leadSponsor name: University of Rzeszow, class: OTHER, descriptionModule briefSummary: Fibromyalgia is a syndrome characterized by chronic, generalized pain in muscles and joints with the presence of characteristic, symmetrically occurring so-called "tender points" - areas of the body that are excessively sensitive to pressure. The condition is associated with a feeling of chronic fatigue, mood and sleep disturbances and a sensation of body stiffness. These complaints are bothersome and significantly impair patients' functioning in every aspect of their lives. There are few studies evaluating the functioning and disability of people with fibromyalgia. No such study has been conducted in Poland to date. Therefore, the purpose of this study is to evaluate the functioning and disability of fibromyalgia patients and the relationship of the level of disability with selected factors, such as pain intensity, emotional state, sleep quality, etc., conditionsModule conditions: Fibromyalgia, conditions: Disabilities Multiple, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CROSSOVER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 700, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: disability, secondaryOutcomes measure: functioning, secondaryOutcomes measure: depression, secondaryOutcomes measure: Sociodemographic data, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Rzeszow, status: RECRUITING, city: Rzeszów, state: Podkarpacie, zip: 35-310, country: Poland, contacts name: Agnieszka Sozańska, professor, role: CONTACT, phone: +48 530172857, email: asozanska@ur.edu.pl, geoPoint lat: 50.04132, lon: 21.99901, hasResults: False
protocolSection identificationModule nctId: NCT06296433, orgStudyIdInfo id: HCB_2023_1196, briefTitle: Extended Reality-Assisted Therapy for Chronic Pain Management, acronym: XR-PAIN, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2024-11-30, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-03-06, lastUpdatePostDateStruct date: 2024-03-18, sponsorCollaboratorsModule leadSponsor name: Institut d'Investigacions Biomèdiques August Pi i Sunyer, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to test a home-based virtual reality rehabilitation application in patients with chronic low back pain. The main question it aims to answer are:Is a prototype of a novel VR software application effective at reducing pain, improving daily function, improving range of motion, and reducing fear of movement in adult patients with chronic low back pain compared with a passive VR intervention? Participants in the treatment group will use the application daily for 20 minutes for a period of 3 weeks at home and unsupervised. Researchers will compare use of the VR application with a control group that watches 2D video to see if the treatment group have improved pain, disability, range of motion, and fear of movement., conditionsModule conditions: Chronic Pain, conditions: Low Back Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: VR rehabilitation, interventions name: VR video application, outcomesModule primaryOutcomes measure: Brief Pain Inventory, secondaryOutcomes measure: Roland-Morris Disability Questionnaire, secondaryOutcomes measure: Short-Form 12, secondaryOutcomes measure: Patient Global Impression of Change, secondaryOutcomes measure: Pain Catastrophization Scale, otherOutcomes measure: Spinal Range of motion, otherOutcomes measure: Adherence to treatment, otherOutcomes measure: Embodiment, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: IDIBAPS, city: Barcelona, zip: 08036, country: Spain, geoPoint lat: 41.38879, lon: 2.15899, hasResults: False