hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06358937, orgStudyIdInfo id: #7/2023, briefTitle: Clinical and Microbiological Evaluation of Laser Assisted New Attachment Procedure (LANAP) Using Nd:Yag vs. Diode Laser in the Management Of Stage II Periodontitis, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-01, primaryCompletionDateStruct date: 2024-05, completionDateStruct date: 2024-05, studyFirstPostDateStruct date: 2024-04-11, lastUpdatePostDateStruct date: 2024-04-11, sponsorCollaboratorsModule leadSponsor name: Mahmoud Salem, class: OTHER, descriptionModule briefSummary: The aim of the present study is to compare the efficacy of LANAP to conventional scaling and root planing in the management of stage II periodontitis., conditionsModule conditions: Periodontal Diseases, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 27, type: ESTIMATED, armsInterventionsModule interventions name: Laser Assisted New Attachment Procedure using ND:YAG laser, interventions name: Laser Assisted New Attachment Procedure using diode laser, interventions name: Scaling and Root Planing using ultrasonic and curettes, outcomesModule primaryOutcomes measure: Microbiological assessment of Fusobacterium nucleatum, primaryOutcomes measure: Microbiological assessment of Porphyromonas gingivalis, primaryOutcomes measure: Microbiological assessment of Tannerella forsythia, secondaryOutcomes measure: Gingival index, secondaryOutcomes measure: Plaque index, secondaryOutcomes measure: Clinical attachment loss, secondaryOutcomes measure: Probing depth, eligibilityModule sex: ALL, minimumAge: 30 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: Faculty of Dentistry, Alexandria University, status: RECRUITING, city: Alexandria, country: Egypt, contacts name: Mahmoud Salem, BDS, role: CONTACT, phone: 111 144 7745, phoneExt: +20, email: Masalem30192@gmail.com, geoPoint lat: 31.21564, lon: 29.95527, hasResults: False
protocolSection identificationModule nctId: NCT06358924, orgStudyIdInfo id: FDASU-RecID032004, briefTitle: Effect of Different Desensitizing Agents on Post-bleaching Hypersensitivity and Shade Stability, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-11-13, primaryCompletionDateStruct date: 2023-08-25, completionDateStruct date: 2023-09-20, studyFirstPostDateStruct date: 2024-04-11, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Ain Shams University, class: OTHER, descriptionModule briefSummary: This study compared the effect of four different desensitizing agents on shade stability and dental hypersensitivity following dental bleaching procedure. The follow-up periods ranged from 24 hours to 1 year., conditionsModule conditions: Tooth Hypersensitivity, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: This clinical study was conducted to evaluate the effect of using different desensitizing agents:1. As recommended by manufacturer2. Casein phosphopeptide-amorphous calcium phosphate/fluoride (CPP-ACPF) containing desensitizing agent3. Hydroxyapatite/fluoride/xylitol containing desensitizing agent4. Poly (amido amine) dendrimer with carboxylic acid terminal functional group containing desensitizing agent.On patients subjected to bleaching procedure using hydrogen peroxide containing bleaching agent.The clinical evaluation included:1. Post-bleaching hypersensitivity.2. Post-bleaching long-term shade stability., primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: DOUBLE, maskingDescription: This clinical trial was double blinded trial in which both the participant and outcome assessor were blinded to allocation, thus the participant was unaware of which experimental material had been assigned to him/her. Also the outcome assessors were blinded to the treatment that each participant had received., whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 48, type: ACTUAL, armsInterventionsModule interventions name: Potassium nitrate with fluoride, interventions name: Casein phosphopeptide-amorphous calcium phosphate with fluoride, interventions name: Hydroxyapatite with fluoride, interventions name: PAMAM-carboxylic acid dendrimer, outcomesModule primaryOutcomes measure: Post-bleaching hypersensitivity, primaryOutcomes measure: Shade stability, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule locations facility: Faculty of Dentistry, Ain Shams University, city: Cairo, state: El Weilli, zip: 4393005, country: Egypt, geoPoint lat: 30.06263, lon: 31.24967, hasResults: False
protocolSection identificationModule nctId: NCT06358911, orgStudyIdInfo id: FDASU-RecID022001, briefTitle: A Clinical Study for the Effect of 4th Generation Poly AmidoAmine Dendrimer on Post-Bleaching Hypersensitivity and Shade Stability, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-11-13, primaryCompletionDateStruct date: 2023-08-05, completionDateStruct date: 2023-09-10, studyFirstPostDateStruct date: 2024-04-11, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Ain Shams University, class: OTHER, descriptionModule briefSummary: This study assessed the impact of four desensitizing agents on both color stability and dental sensitivity following a bleaching procedure, spanning from the 24-hour to the 1-year follow-up assessment periods., conditionsModule conditions: Tooth Hypersensitivity, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: This clinical study will be conducted to evaluate the effect of using 4th generation Poly amido amine dendrimer (PAMAM-COOH) as a desensitizing agent and compared with three different commercially available desensitizing materials: 3% potassium nitrate and 0.11% fluoride (Ultra EZ), as described by manufacturer, Casein-phosphopeptide-amorphous calcium phosphate with F, (MI paste plusTm), and Hydroxyapatite, Fluoride and Xylitol, Hydroxyapatite and F (ReminPro), on:1. Long-term Post-bleaching hypersensitivity.2. Long-term Post-bleaching shade stability. For Patients treated with 40% hydrogen-peroxide bleaching agent., primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: DOUBLE, maskingDescription: This clinical trail was a double blinded trail in which the participant and outcome assessor were blinded to allocation, thus the participant was unaware of which experimental material had been assigned to him/her. Also outcome assessors were blinded to the treatment that each participant had received, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ACTUAL, armsInterventionsModule interventions name: Poly amido amine dendrimer (PAMAM), interventions name: Manufacturer's desensitizing agent, Ultra EZ, interventions name: MI paste plus, desensitizing agent, interventions name: Hydroxyapatite and F (ReminPro), desensitizing agent, outcomesModule primaryOutcomes measure: Post-bleaching dental hypersensitivity, primaryOutcomes measure: Shade stability, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule locations facility: Faculty of Dentistry - Ain Shams University, city: Cairo, state: El Weili, zip: 4393005, country: Egypt, geoPoint lat: 30.06263, lon: 31.24967, hasResults: False
protocolSection identificationModule nctId: NCT06358898, orgStudyIdInfo id: 20221207, briefTitle: Digital Mood-enhanced CBT-I to Improve Depressive Symptoms in Adolescents, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-18, primaryCompletionDateStruct date: 2026-05-31, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-04-11, lastUpdatePostDateStruct date: 2024-04-12, sponsorCollaboratorsModule leadSponsor name: Chinese University of Hong Kong, class: OTHER, descriptionModule briefSummary: Emerging encouraging evidence showed that sleep focused treatment can simultaneously improve sleep and depression in adult with comorbid conditions. Although these favorable changes in depressed adults is encouraging, little is known in the potential efficacy of CBT-I in altering depression trajectory in adolescent population. This current study aims to compare the effect of digitally delivered, mood enhanced cognitive behavioral therapy for insomnia (M-dCBT-I) and standard digital cognitive behavioral therapy for insomnia (dCBT-I) in improving depressive symptoms in adolescents, and to examine the potential sustained treatment effect in mood outcomes following M-dCBT-I or dCBT-I treatment., conditionsModule conditions: Insomnia, conditions: Depression, conditions: Adolescent, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 343, type: ESTIMATED, armsInterventionsModule interventions name: Standard dCBT-I, interventions name: Modified Mood enhanced CBT-I (M-dCBT-I), outcomesModule primaryOutcomes measure: Depressive symptoms, secondaryOutcomes measure: Assessor-rated depressive symptomatology, secondaryOutcomes measure: Overall severity of depression symptoms, secondaryOutcomes measure: Severity of insomnia symptoms, secondaryOutcomes measure: Sleep-wake pattern, secondaryOutcomes measure: Sleep-related beliefs and cognitions, secondaryOutcomes measure: Daytime sleepiness, secondaryOutcomes measure: Anxiety and depression symptoms, secondaryOutcomes measure: Quality of life by KIDSCREEN-27, otherOutcomes measure: Major life events and self-perceived stress, otherOutcomes measure: Chronotype, otherOutcomes measure: Pubertal status, eligibilityModule sex: ALL, minimumAge: 12 Years, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Department of Psychiatry, the Chinese University of Hong Kong, city: Sha Tin, state: New Territories, country: Hong Kong, geoPoint lat: 22.38333, lon: 114.18333, hasResults: False
protocolSection identificationModule nctId: NCT06358846, orgStudyIdInfo id: 00004, briefTitle: Effectiveness of Educational Intervention on Footcare Among Individuals Having Type 2 Diabetes at Slums of Karachi, Pakistan., statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-15, primaryCompletionDateStruct date: 2024-07-15, completionDateStruct date: 2024-07-31, studyFirstPostDateStruct date: 2024-04-11, lastUpdatePostDateStruct date: 2024-04-12, sponsorCollaboratorsModule leadSponsor name: SINA Health Education and Welfare Trust, class: OTHER, collaborators name: Aga Khan University, descriptionModule briefSummary: There are multiple studies conducted in Pakistan that supports the topic of foot care knowledge among individual with type 2 diabetes but all are descriptive cross-sectional studies and investigators cannot develop cause effect relationship out of it. Secondly, there is a lack of documented research on the foot care knowledge shown by people with T2D residing in the slums of Karachi. In order to assess the knowledge intervention among the individual having T2D through qualified diabetes educators and pictorial educational pamphlet along with the standard care of treatment. Consequently, it may aid in the development of effective methods aimed at mitigating foot-related complications among this specific population. Individuals diagnosed with diabetes are required to engage in proactive and structured self-care activities by providing the foot care knowledge in order to effectively manage their condition and mitigate the risk of potential complications. The incorporation of health-deviation knowledge and activities into routine is crucial., conditionsModule conditions: Diabetic Foot, conditions: Educational Intervention, conditions: Foot Care, conditions: Foot Ulcer, Diabetic, conditions: Foot Cellulitis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Control arm =75 Interventional arm = 75, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 150, type: ESTIMATED, armsInterventionsModule interventions name: Self-care behavior to promote foot care through educational guidance among individual with diabetes, outcomesModule primaryOutcomes measure: Improved Foot Care Knowledge, primaryOutcomes measure: Behavior Change, secondaryOutcomes measure: Reduction in Foot Complications, secondaryOutcomes measure: Empowerment and Self-efficacy, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06358833, orgStudyIdInfo id: 24-82-03, briefTitle: Comparison of Endodontic Postoperative Pain Using Different Irrigation Systems, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-15, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-04-11, lastUpdatePostDateStruct date: 2024-04-18, sponsorCollaboratorsModule leadSponsor name: Qassim University, class: OTHER, descriptionModule briefSummary: Summary:After a root canal procedure, it is common to experience postoperative pain. Cleaning the root canal thoroughly is crucial for pain relief, but removing all debris with standard methods is difficult. Irrigation, using either traditional endodontic needles or newer methods like endodontic activation, helps clean the canal. This study aims to compare pain levels after using conventional needles versus an Endo1 Ultrasonic Endo Activate Device for irrigation. Patients will undergo standard root canal preparation and then be randomly assigned to one of two groups for final irrigation: the Endo1 device (EA) and the conventional endodontic needles (EN). The study will provide insights into which method is more effective in reducing postoperative pain., conditionsModule conditions: Postoperative Pain, conditions: Irreversible Pulpitis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: Patients will be masked from the procedure, whoMasked: PARTICIPANT, enrollmentInfo count: 34, type: ESTIMATED, armsInterventionsModule interventions name: endodontic needle (EN), interventions name: Endodontic activation (EA), outcomesModule primaryOutcomes measure: Postoperative pain, primaryOutcomes measure: Postoperative pain, primaryOutcomes measure: Postoperative pain, primaryOutcomes measure: Postoperative pain, secondaryOutcomes measure: Irrigation time, otherOutcomes measure: Adverse event, otherOutcomes measure: Rescue medication, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Muhammad Zubair Ahmad, status: RECRUITING, city: Ar Rass, state: Qassim, zip: 58883, country: Saudi Arabia, contacts name: Muhammad Zubair Ahmad, BDS, FCPS, role: CONTACT, phone: 0163011111, phoneExt: 10685, email: m.muhammad@qu.edu.sa, geoPoint lat: 25.86944, lon: 43.4973, hasResults: False
protocolSection identificationModule nctId: NCT06358820, orgStudyIdInfo id: PHGaozhou, briefTitle: Exploring the Effectiveness and Safety of Amino Acid Peritoneal Dialysis Solution, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-03, primaryCompletionDateStruct date: 2025-01, completionDateStruct date: 2025-07, studyFirstPostDateStruct date: 2024-04-11, lastUpdatePostDateStruct date: 2024-04-11, sponsorCollaboratorsModule leadSponsor name: The People's Hospital of Gaozhou, class: OTHER, descriptionModule briefSummary: This study adopts a multicenter, open, prospective, and self controlled study design, in which each participant serves as their own control before and after receiving amino acid peritoneal dialysis solution treatment to compare changes in their nutritional status. Each subject received treatment with 1 bag of amino acid peritoneal dialysis per day and 2-4 bags of glucose peritoneal dialysis solution per day for 6 months (the amount of glucose peritoneal dialysis solution used was determined based on the treatment plan selected by the patient during the screening period when they entered the study).Before treatment and during the 3rd and 6th months of treatment, subjects were evaluated for various efficacy and safety indicators, and any adverse or serious adverse events were recorded., conditionsModule conditions: Exploring the Effectiveness and Safety of Amino Acid Peritoneal Dialysis Solution in Improving Nutritional Status of Maintenance Peritoneal Dialysis Patients, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 140, type: ESTIMATED, armsInterventionsModule interventions name: Amino acid peritoneal dialysis solution, outcomesModule primaryOutcomes measure: blood albumin, primaryOutcomes measure: prealbumin, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Gaozhou People's Hospital, status: RECRUITING, city: Gaozhou, state: Guangdong, zip: 525200, country: China, contacts name: Deng shanshan, role: CONTACT, phone: 8613927596600, email: 276531255@qq.com, geoPoint lat: 21.93924, lon: 110.84607, hasResults: False
protocolSection identificationModule nctId: NCT06358807, orgStudyIdInfo id: M2023438, briefTitle: Microfracture With Platelet Rich Plasma Gel Injection for Ostechondral Lesion of the Talus, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2025-01-01, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-04-11, lastUpdatePostDateStruct date: 2024-04-11, sponsorCollaboratorsModule leadSponsor name: Peking University Third Hospital, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to learn if combined local injection of platelet rich plasma (PRP) gel adds clinical efficacy to isolated arthroscopic microfracture in treatment of osteochondral lesion of the talus (OLT). The interface integration of the injured area will also be assessed via radiographic follow-up. The main questions it aims to answer are:* Does arthroscopic microfracture combined with PRP gel injection improve ankle function of participants based on American Orthopedic Foot and Ankle Society (AOFAS) Score?* Does arthroscopic microfracture combined with PRP gel injection improve interface integration of the injured cartilage on magnetic resonance imaging (MRI)? Researchers will compare arthroscopic microfracture with concomitant local injection of PRP gel to isolated microfracture to see if intraoperative PRP gel injection adds clinical efficacy to isolated arthroscopic microfracture in treatment of OLT.Participants will:* Undergo either isolated arthroscopic microfracture or microfracture with intraoperative injection of PRP gel* Receive clinical follow-up 3, 6, 12, and 24 months after surgery and answer scales of ankle function assessment* Take MRI preoperatively and 6, 12 and 24 months after surgery, conditionsModule conditions: Osteochondral Lesion of Talus, conditions: Microfractures, conditions: Platelet Rich Plasma, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 70, type: ESTIMATED, armsInterventionsModule interventions name: Arthroscopic microfracture with intraoperative local PRP gel injection, interventions name: Isolated microfracture, outcomesModule primaryOutcomes measure: American Orthopedic Foot and Ankle Society Score (AOFAS), secondaryOutcomes measure: Foot and Ankle Outcome Score (FAOS), secondaryOutcomes measure: Ankle Activity Score (AAS), secondaryOutcomes measure: Visual Analogue Scale (VAS), secondaryOutcomes measure: Patient Satisfaction, secondaryOutcomes measure: Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART), secondaryOutcomes measure: Return-to-Sport Rate, secondaryOutcomes measure: Complications, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Peking University Third Hospital, status: RECRUITING, city: Beijing, country: China, contacts name: Guo Qinwei, role: CONTACT, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False
protocolSection identificationModule nctId: NCT06358794, orgStudyIdInfo id: IRB00006761-M2022692, briefTitle: Machine Learning Based-Personalized Prediction of Sperm Retrieval Success Rate, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-06-01, primaryCompletionDateStruct date: 2022-12-31, completionDateStruct date: 2023-05-31, studyFirstPostDateStruct date: 2024-04-11, lastUpdatePostDateStruct date: 2024-04-11, sponsorCollaboratorsModule leadSponsor name: Peking University Third Hospital, class: OTHER, descriptionModule briefSummary: Non-obstructive azoospermia (NOA) stands as the most severe form of male infertility. However, due to the diverse nature of testis focal spermatogenesis in NOA patients, accurately assessing the sperm retrieval rate (SRR) becomes challenging. The current study aims to develop and validate a noninvasive evaluation system based on machine learning, which can effectively estimate the SRR for NOA patients. In single-center investigation, NOA patients who underwent microdissection testicular sperm extraction (micro-TESE) were enrolled: (1) 2,438 patients from January 2016 to December 2022, and (2) 174 patients from January 2023 to May 2023 (as an additional validation cohort). The clinical features of participants were used to train, test and validate the machine learning models. Various evaluation metrics including area under the ROC (AUC), accuracy, etc. were used to evaluate the predictive performance of 8 machine learning models., conditionsModule conditions: Infertility, Male, conditions: Azoospermia, Nonobstructive, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 2612, type: ACTUAL, armsInterventionsModule interventions name: Machine learning-based predictive model, outcomesModule primaryOutcomes measure: SRR of micro-TESE, eligibilityModule sex: MALE, minimumAge: 20 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Peking University Third Hospital, city: Beijing, state: Beijing, zip: 100191, country: China, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False