protocolSection identificationModule nctId: NCT06284213, orgStudyIdInfo id: 5U24NS100591, type: NIH, link: https://reporter.nih.gov/quickSearch/5U24NS100591, briefTitle: Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium, acronym: MarkVCID, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-09-29, primaryCompletionDateStruct date: 2027-07, completionDateStruct date: 2027-07, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Massachusetts General Hospital, class: OTHER, collaborators name: Duke University, collaborators name: Johns Hopkins University, collaborators name: University of New Mexico, collaborators name: University of Southern California, collaborators name: University of Kentucky, collaborators name: Rush University Medical Center, collaborators name: University of Maryland, Baltimore, collaborators name: University of California, San Francisco, collaborators name: University of California, Los Angeles, collaborators name: University of California, Davis, collaborators name: University of Texas, collaborators name: The University of Texas Health Science Center at San Antonio, collaborators name: The University of Texas Health Science Center, Houston, collaborators name: Mayo Clinic, collaborators name: University of Mississippi Medical Center, collaborators name: Washington University School of Medicine, collaborators name: Olive View-UCLA Education & Research Institute, descriptionModule briefSummary: Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID) is an NIH-funded consortium dedicated to finding biomarkers involved in age-related thinking and memory problems. Alzheimer's disease and other dementias leave signatures on brain scans or in the blood called biomarkers. The MarkVCID study will measure a panel of candidate biomarkers in 1800 participants and watch them closely to see what they tell us about changes in brain function and risk of memory loss.Age-related problems in thinking and memory represent some of the greatest risks to public health in the US and globally. Diseases that affect small blood vessels in the brain have been shown to be major contributors to these changes. However, research and patient care can be held back by limited biomarkers that identify who should be treated.The MarkVCID Consortium includes 17 US medical centers, a Coordinating Center, an External Advisory Committee, and NIH leadership. Data and biospecimens collected as part of this research study will be stored in a research database and biorepositories, so that researchers can use this information to study brain function., conditionsModule conditions: Cognitive Impairment, conditions: Dementia, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 1800, type: ESTIMATED, armsInterventionsModule interventions name: No interventions, outcomesModule primaryOutcomes measure: SVD progression as measured by decline in global cognition, secondaryOutcomes measure: SVD progression as measured by decline in executive function, eligibilityModule sex: ALL, minimumAge: 60 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Southern California, status: RECRUITING, city: Los Angeles, state: California, zip: 90033, country: United States, contacts name: Danny JJ Wang, PhD, MSCE, role: CONTACT, phone: 323-442-7246, email: JJ.Wang@loni.usc.edu, geoPoint lat: 34.05223, lon: -118.24368, locations facility: University of California Los Angeles, status: RECRUITING, city: Los Angeles, state: California, zip: 90095, country: United States, contacts name: Jason Hinman, MD, PhD, role: CONTACT, phone: 310-794-1195, email: JHinman@mednet.ucla.edu, geoPoint lat: 34.05223, lon: -118.24368, locations facility: University of California Davis, status: RECRUITING, city: Sacramento, state: California, zip: 95817, country: United States, contacts name: Pauline Maillard, PhD, role: CONTACT, phone: 916-734-3588, email: pmaillard@ucdavis.edu, geoPoint lat: 38.58157, lon: -121.4944, locations facility: University of California San Francisco, status: RECRUITING, city: San Francisco, state: California, zip: 94158, country: United States, contacts name: Joel Kramer, PsyD, role: CONTACT, phone: 415-476-5572, email: Joel.Kramer@ucsf.edu, geoPoint lat: 37.77493, lon: -122.41942, locations facility: Olive View - UCLA Medical Center, status: RECRUITING, city: Sylmar, state: California, zip: 91342, country: United States, contacts name: Keith Vossel, MD, role: CONTACT, phone: 310-794-1195, email: KVossel@mednet.ucla.edu, geoPoint lat: 34.30778, lon: -118.44925, locations facility: Mayo Clinic Florida, status: RECRUITING, city: Jacksonville, state: Florida, zip: 32224, country: United States, contacts name: Gregory Day, role: CONTACT, phone: 904-953-0856, email: Day.Gregory@mayo.edu, geoPoint lat: 30.33218, lon: -81.65565, locations facility: Rush University Medical Center & Illinois Institute of Technology, status: RECRUITING, city: Chicago, state: Illinois, zip: 60612, country: United States, contacts name: Konstantinos Arfanakis, PhD, role: CONTACT, phone: 312-567-3864, email: Konstantinos_Arfanakis@rush.edu, geoPoint lat: 41.85003, lon: -87.65005, locations facility: University of Kentucky, status: RECRUITING, city: Lexington, state: Kentucky, zip: 40536, country: United States, contacts name: Gregory Jicha, MD, PhD, role: CONTACT, phone: 859-257-1000, email: gregory.jicha@uky.edu, geoPoint lat: 37.98869, lon: -84.47772, locations facility: University of Maryland, Baltimore, status: RECRUITING, city: Baltimore, state: Maryland, zip: 21201, country: United States, contacts name: Peiying Liu, PhD, role: CONTACT, phone: 410-706-2441, email: PeiyingLiu@som.umaryland.edu, geoPoint lat: 39.29038, lon: -76.61219, locations facility: Johns Hopkins University, status: RECRUITING, city: Baltimore, state: Maryland, zip: 21287, country: United States, contacts name: Hanzhang Lu, PhD, role: CONTACT, phone: 410-955-1431, email: hlu3@jhmi.edu, geoPoint lat: 39.29038, lon: -76.61219, locations facility: Mayo Clinic Rochester, status: RECRUITING, city: Rochester, state: Minnesota, zip: 55901, country: United States, contacts name: Ronald Petersen, MD, PhD, role: CONTACT, phone: 507-284-1588, email: peter8@mayo.edu, geoPoint lat: 44.02163, lon: -92.4699, locations facility: University of Mississippi Medical Center, status: RECRUITING, city: Jackson, state: Mississippi, zip: 39216, country: United States, contacts name: Gwen Windham, MD, role: CONTACT, phone: 601-984-5610, email: gwindham@umc.edu, geoPoint lat: 32.29876, lon: -90.18481, locations facility: Washington University in St. Louis, status: RECRUITING, city: Saint Louis, state: Missouri, zip: 63110, country: United States, contacts name: Jin-Moo Lee, MD, PhD, role: CONTACT, phone: 314-362-7382, email: leejm@wustl.edu, geoPoint lat: 38.62727, lon: -90.19789, locations facility: University of New Mexico, status: RECRUITING, city: Albuquerque, state: New Mexico, zip: 87131, country: United States, contacts name: Gary Rosenberg, MD, role: CONTACT, phone: 505-272-3315, email: GRosenberg@salud.unm.edu, geoPoint lat: 35.08449, lon: -106.65114, locations facility: University of Texas Southwestern, status: RECRUITING, city: Dallas, state: Texas, zip: 75390, country: United States, contacts name: Rong Zhang, PhD, role: CONTACT, phone: 214-345-4619, email: RongZhang@texashealth.org, geoPoint lat: 32.78306, lon: -96.80667, locations facility: University of Texas Health Science Center Houston, status: RECRUITING, city: Houston, state: Texas, zip: 77030, country: United States, contacts name: Sean Savitz, MD, role: CONTACT, phone: 713-500-7083, email: Sean.I.Savitz@uth.tmc.edu, geoPoint lat: 29.76328, lon: -95.36327, locations facility: University of Texas Health Science Center San Antonio, status: RECRUITING, city: San Antonio, state: Texas, zip: 78229, country: United States, contacts name: Claudia Satizabal, PhD, role: CONTACT, phone: 210-450-8417, email: satizabal@uthscsa.edu, geoPoint lat: 29.42412, lon: -98.49363, hasResults: False