protocolSection identificationModule nctId: NCT06340295, orgStudyIdInfo id: 2023313, briefTitle: A Multicenter, Prospective Cohort Study of Preserved Ratio Impaired Spirometry(PRISm) in a Population, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-09-01, primaryCompletionDateStruct date: 2026-05-31, completionDateStruct date: 2026-05-31, studyFirstPostDateStruct date: 2024-04-01, lastUpdatePostDateStruct date: 2024-04-01, sponsorCollaboratorsModule leadSponsor name: Peking University First Hospital, class: OTHER, collaborators name: Shanxi Bethune Hospital, collaborators name: First Affiliated Hospital Xi'an Jiaotong University, collaborators name: Tianjin Medical University General Hospital, collaborators name: The First Hospital of Qinhuangdao, collaborators name: Shandong Provincial Hospital, collaborators name: Second Hospital of Jilin University, collaborators name: People's Hospital of Xinjiang Uygur Autonomous Region, collaborators name: MinDong Hospital of Ningde City, descriptionModule briefSummary: Chronic obstructive pulmonary disease (COPD) is the most common chronic tract disease and the third leading cause of death worldwide. The treatment effect of COPD is poor, and the disease is progressive, resulting in a serious disease burden. The key reason is that early recognition is difficult and the early pathophysiological mechanism is unclear, which leads to the difficulty of early intervention.PRISm is likely to be the precursor stage of COPD, which may provide an important research object for the study of pathophysiological characteristics, inflammation and immunomodulatory mechanisms of early COPD, and may also become a new entry point for early intervention of COPD. This study attempts to establish a PRISm prospective cohort，and collects blood, EBC and urine for analysis of inflammatory factors, metabolomics, proteomics and microbiome, and performs chest HRCT to obtain imaging indicators, and conducts 3-year dynamic follow-up observation to study the evolution characteristics of pulmonary function and the incidence of COPD in the PRISm cohort. To compare the differences in imaging, inflammatory factors, metabolomics, proteomics and microbiome among the three PRISm groups, and establish a risk prediction model for progression to COPD through PRISm. It lays a foundation for understanding the characteristics of COPD at an earlier stage and exploring new early warning indicators., conditionsModule conditions: COPD, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 2000, type: ESTIMATED, armsInterventionsModule interventions, outcomesModule primaryOutcomes measure: The number and proportion of newly diagnosed COPD, secondaryOutcomes measure: The number and proportion of continuous PRISm population, secondaryOutcomes measure: The number and proportion of PRISm to normal population, secondaryOutcomes measure: Emerging diseases, secondaryOutcomes measure: Death and cause of death, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Peking University First Hospital, status: RECRUITING, city: Beijing, state: Beijing, zip: 100034, country: China, contacts name: Jiping Liao, MD., role: CONTACT, phone: 13521714181, email: colorfulwing01@163.com, contacts name: Chunbo Zhang, role: CONTACT, phone: 13086645758, email: 2399637945@qq.com, contacts name: Jiping Liao, MD., role: PRINCIPAL_INVESTIGATOR, contacts name: Guangfa Wang, MD., role: SUB_INVESTIGATOR, contacts name: Zhe Jin, MD., role: SUB_INVESTIGATOR, contacts name: Meng Zhang, role: SUB_INVESTIGATOR, contacts name: Yan Hu, MD., role: SUB_INVESTIGATOR, contacts name: Chunbo Zhang, role: SUB_INVESTIGATOR, contacts name: Xueying Li, role: SUB_INVESTIGATOR, contacts name: Jian Chen, role: SUB_INVESTIGATOR, geoPoint lat: 39.9075, lon: 116.39723, locations facility: Peking University First Hospital, status: RECRUITING, city: Beijing, state: Beijing, zip: 100034, country: China, contacts name: Guangfa Wang, MD, role: CONTACT, phone: 13810644029, email: wangguangfa@hotmail.com, contacts name: Jiping Liao, MD, role: CONTACT, phone: 13521714181, email: colorfulwing01@163.com, contacts name: Yunxia Wang, PhD, role: SUB_INVESTIGATOR, contacts name: Yijue Zhong, PhD, role: SUB_INVESTIGATOR, contacts name: Chao Sun, PhD, role: SUB_INVESTIGATOR, geoPoint lat: 39.9075, lon: 116.39723, locations facility: The First Hospital of Qinhuangdao, status: RECRUITING, city: Qinhuangdao, state: Hebei, country: China, contacts name: Hua Qiao, MD, role: CONTACT, phone: 13780358298, email: qh1202@163.com, geoPoint lat: 39.93167, lon: 119.58833, locations facility: Tianjin Medical University General Hospital, status: RECRUITING, city: Tianjin, state: Tianjin, country: China, contacts name: Lixia Dong, MD, role: CONTACT, phone: 13001385918, email: luckydonglixia@163.com, geoPoint lat: 39.14222, lon: 117.17667, locations facility: Shandong Provincial Hospital Affiliated to Shandong University, status: RECRUITING, city: Jing'an, country: China, contacts name: Jian Sun, MD, role: CONTACT, email: docbenjaminsun@163.com, locations facility: Shanxi Bethune Hospital, status: RECRUITING, city: Taiyuan, country: China, contacts name: Ruiying Wang, MD, role: CONTACT, phone: +86 13903436432, email: wry0526@163.com, geoPoint lat: 37.86944, lon: 112.56028, hasResults: False