protocolSection identificationModule nctId: NCT06304194, orgStudyIdInfo id: BIOMARC_ONCO, briefTitle: Molecular Characterizazion and Biological Samples Centralisation of Patients Affected by Oncoematolofic Pathology, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-07-05, primaryCompletionDateStruct date: 2027-07-05, completionDateStruct date: 2028-07-05, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: Meyer Children's Hospital IRCCS, class: OTHER, descriptionModule briefSummary: Currently, the molecular characterization of onco-hematological, onco-immunological and hematological diseases, at onset or in relapse, of patients with suspected diagnosis afferent to the CROP centers, is done through centralization of biological samples at reference laboratories outside the Tuscany Region.In order to preserve the wealth of clinical and biological data and use it for the benefit of present and future patients treated at the CROP centers, it is useful to evaluate the feasibility of centralization and molecular typing of mutations present in tumor tissue at the IRCCS AOU Meyer Oncohematology Laboratories and subsequently the analysis of clinical data from patients with diseases not under study to lay the foundations of a translational database that can then be associated with a biobank in the future.This will enable a targeted contribution to pediatric oncohematology research, investing in possible targeted therapies with those patient subgroups that benefit from personalized disease assessment in mind. The goal of the project is to improve the regional infrastructure dedicated to organized data collection and management of biological samples in adequate time resulting in better and more comprehensive data collection., conditionsModule conditions: Oncologic Disease, conditions: Hematologic Diseases, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: SCREENING, maskingInfo masking: NONE, enrollmentInfo count: 340, type: ESTIMATED, armsInterventionsModule interventions name: Analysis of biological samples, outcomesModule primaryOutcomes measure: Average sample delivery time and % of accepted sample, primaryOutcomes measure: Appropriateness sample labelling, primaryOutcomes measure: Percentage of sample suitable for RNA extraction, primaryOutcomes measure: Quantity and quality of extracted material., primaryOutcomes measure: Research report production time, secondaryOutcomes measure: Genetic variants, secondaryOutcomes measure: Completed patient cards, eligibilityModule sex: ALL, minimumAge: 0 Years, maximumAge: 30 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Meyer Children's Hospital IRCCS, status: RECRUITING, city: Florence, country: Italy, contacts name: Marinella Veltroni, role: CONTACT, email: marinella.veltroni@meyer.it, geoPoint lat: 43.77925, lon: 11.24626, locations facility: Azienda Ospedaliero-Universitaria Pisana, status: RECRUITING, city: Pisa, country: Italy, contacts name: Gabriella Casazza, role: CONTACT, geoPoint lat: 43.70853, lon: 10.4036, locations facility: Azienda Ospedaliero-Universitaria Senese, status: RECRUITING, city: Siena, country: Italy, contacts name: Salvatore Grosso, role: CONTACT, geoPoint lat: 43.31822, lon: 11.33064, hasResults: False