protocolSection identificationModule nctId: NCT06367218, orgStudyIdInfo id: S058, briefTitle: Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2026-07-01, completionDateStruct date: 2026-08-01, studyFirstPostDateStruct date: 2024-04-16, lastUpdatePostDateStruct date: 2024-04-16, sponsorCollaboratorsModule leadSponsor name: Tongji Hospital, class: OTHER, descriptionModule briefSummary: Non-tracheal intubated combined anesthesia with preserved spontaneous breathing significantly enhances the quality and speed of recovery post-VATS for patients undergoing lung nodule surgery. The "opioid-sparing strategy," which substitutes ketamine for opioids during surgery, not only provides effective analgesia but also protects perioperative lung function and reasonably prevents the occurrence of opioid-related adverse reactions; it also reduces medical costs and shortens the average hospital stay. However, the degree of benefit to patients lacks high-level clinical evidence. This study aims to comprehensively assess the effect of opioid-free combined anesthesia with preserved spontaneous breathing for VATS lung nodule surgery on postoperative rapid recovery from multiple aspects including postoperative lung function and pulmonary complications, pain, gastrointestinal function, nausea/vomiting, cognitive function, and depression/anxiety, intending to expand the dataset and application prospects in this field, and increase feasibility experience., conditionsModule conditions: Video-assisted Thoracoscopic Lung Surgery；Anesthesia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 480, type: ESTIMATED, armsInterventionsModule interventions name: opioid based strategy, interventions name: opioid-free strategy, interventions name: Laryngeal mask airway; Preserved spontaneous breathing, interventions name: Double lumen tracheal tube; Mechanical ventilation, outcomesModule primaryOutcomes measure: Lung function 30 days after surgery, secondaryOutcomes measure: Intraoperative respiratory parameters, secondaryOutcomes measure: Intraoperative respiratory parameters, secondaryOutcomes measure: Intraoperative respiratory parameters, secondaryOutcomes measure: Intraoperative respiratory parameters, secondaryOutcomes measure: Intraoperative respiratory parameters, secondaryOutcomes measure: Perioperative stage indicators, secondaryOutcomes measure: Perioperative stage indicators, secondaryOutcomes measure: Postoperative pain, secondaryOutcomes measure: Postoperative Lung function, secondaryOutcomes measure: Postoperative Lung function, secondaryOutcomes measure: Postoperative pulmonary complications, secondaryOutcomes measure: Postoperative gastrointestinal function, secondaryOutcomes measure: Postoperative depression/anxiety, secondaryOutcomes measure: Postoperative cognitive function, secondaryOutcomes measure: Time of first exercise after surgery, secondaryOutcomes measure: The 6-minute walking experiment, secondaryOutcomes measure: Length of stay, secondaryOutcomes measure: Quality of life measurement, secondaryOutcomes measure: Intraoperative circulation parameters, secondaryOutcomes measure: Intraoperative circulation parameters, secondaryOutcomes measure: Intraoperative circulation parameters, secondaryOutcomes measure: Intraoperative circulation parameters, secondaryOutcomes measure: Intraoperative circulation parameters, secondaryOutcomes measure: Intraoperative circulation parameters, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False