protocolSection identificationModule nctId: NCT06312943, orgStudyIdInfo id: APHP180414, secondaryIdInfos id: 2022-A02170-43, type: OTHER, domain: France : Ministry of Health, briefTitle: "Translating Articular Biomarkers Into Diagnoses", acronym: ARTBioSes, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2027-04, completionDateStruct date: 2027-09, studyFirstPostDateStruct date: 2024-03-15, lastUpdatePostDateStruct date: 2024-03-15, sponsorCollaboratorsModule leadSponsor name: Assistance Publique - Hôpitaux de Paris, class: OTHER, collaborators name: Institut National de la Santé Et de la Recherche Médicale, France, descriptionModule briefSummary: Early diagnosis is a key factor in the prevention and management of rheumatic diseases. Rheumatic diseases are classically diagnosed based on criteria combining clinical, biological and radiological features. However, in up to 20% of the cases, diagnoses remain unstated and underlying rheumatic diseases unclassified, which might lead to delayed specific treatment and unfavourable clinical outcomes. In addition, conventional methods could lack sensitivity and specificity for early diagnosis. Biological samples are attractive targets for the early detection of articular damage because they allow for collection of multiple levels of information from the clinic and the laboratory\]. Biological samples most frequently collected from patients with rheumatic diseases are synovial fluid by joint aspiration, blood by venous puncture and tissue specimen by surgery. The investigators hypothesize that in challenging situations, novel biomarkers detected from synovial fluid or articular tissues using both conventional (e.g. histology, immunodetection, PCR) and innovative (e.g. Raman spectroscopy, nanospectroscopy) laboratory tests may help refining diagnosis and better classifying patients with rheumatic diseases., conditionsModule conditions: Inflammatory and Non-inflammatory Bone and Joint Diseases, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Collection of joint fluid or tissue sample, outcomesModule primaryOutcomes measure: Tissues and biofluid spectra using surface-enhanced Raman spectroscopy, primaryOutcomes measure: Protein expression using immunodetection techniques and RNA expression using PCR, secondaryOutcomes measure: Tissues and biofluid spectra using surface-enhanced Raman spectroscopy, secondaryOutcomes measure: Protein expression using immunodetection techniques and RNA expression using PCR, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Service de Médecine Physique et de Réadaptation, Hôpital Cochin, city: Paris, state: IDF, zip: 75014, country: France, contacts name: Christelle Nguyen, MD, PhD, role: CONTACT, phone: 00 33 1 58 41 29 45, email: christelle.nguyen2@aphp.fr, contacts name: MD, PhD, role: CONTACT, contacts name: François Rannou, MD, PhD, role: SUB_INVESTIGATOR, contacts name: Didier Borderie, MD, PhD, role: SUB_INVESTIGATOR, geoPoint lat: 48.85341, lon: 2.3488, hasResults: False