protocolSection identificationModule nctId: NCT06270901, orgStudyIdInfo id: BMEL: 2822EPS008, briefTitle: Acute Effects of Legume-enriched Meals Compared to Western Diet Meals on Postprandial Metabolism in Participants With Increased Cardiometabolic Risk, acronym: LeguPlan_1, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2024-07-30, completionDateStruct date: 2024-07-30, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-04-15, sponsorCollaboratorsModule leadSponsor name: University of Bonn, class: OTHER, collaborators name: Federal Ministry of Food and Agriculture (BMEL), collaborators name: Federal Office for Agriculture and Food (BLE), descriptionModule briefSummary: The aim of the study is to investigate the postprandial effects of legume-enriched meals compared to Western Diet meals on postprandial metabolism. In this context, older adults with increased risk for cardiometabolic diseases consume 4 mixed meals with 36 g or 62 g of protein either designed according to the Planetary Health Diet with legumes as primary protein source or the Western Diet with animal foods as primary protein source, in a randomized order. In a postprandial observation period of 6 hours, parameters of lipid metabolism, glucose and insulin metabolism, amino acid profile, as well as markers of inflammation and vascular function are analysed. Furthermore, neuropsychological parameters and satiety-associated hormones are investigated., conditionsModule conditions: Cardiovascular Diseases, conditions: Metabolic Syndrome, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule interventions name: High Protein Planetary Health Diet, interventions name: Low Protein Planetary Health Diet, interventions name: High Protein Western Diet, interventions name: Low Protein Western Diet, outcomesModule primaryOutcomes measure: Parameters of lipid metabolism in blood, secondaryOutcomes measure: Parameters of lipid metabolism in blood, secondaryOutcomes measure: Parameters of lipid metabolism in blood, secondaryOutcomes measure: Parameters of lipid metabolism in blood, secondaryOutcomes measure: Parameters of lipid metabolism in blood, secondaryOutcomes measure: Parameters of glucose metabolism in blood, secondaryOutcomes measure: Parameters of glucose metabolism in blood, secondaryOutcomes measure: Parameters of glucose metabolism in blood, secondaryOutcomes measure: Parameters of glucose metabolism in blood, secondaryOutcomes measure: Parameters of glucose metabolism in blood, secondaryOutcomes measure: Blood amino acid profile, secondaryOutcomes measure: Blood urea, secondaryOutcomes measure: Uric acid in blood, secondaryOutcomes measure: Parameters of hunger and satiety in blood, secondaryOutcomes measure: Parameters of endothelial function in blood, secondaryOutcomes measure: Parameters of inflammation in blood, secondaryOutcomes measure: Endothelial function, secondaryOutcomes measure: Neuropsychological parameters, secondaryOutcomes measure: Neuropsychological parameters, secondaryOutcomes measure: Neuropsychological parameters, eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Bonn, Institute of Nutritional and Food Sciences, Nutrition Physiology, status: RECRUITING, city: Bonn, state: North-Rhine Westphalia, zip: 53115, country: Germany, contacts name: Sarah Egert, Prof. Dr., role: CONTACT, phone: + 49 (0) 228 / 73 59, email: s.egert@uni-bonn.de, geoPoint lat: 50.73438, lon: 7.09549, hasResults: False