protocolSection identificationModule nctId: NCT06299722, orgStudyIdInfo id: N-20230055, briefTitle: Strength Training Exercises to Minimise Late Effects of Childhood Leukaemia or Lymphoma Among Adolescents, acronym: STEEL, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-15, primaryCompletionDateStruct date: 2025-07, completionDateStruct date: 2025-07, studyFirstPostDateStruct date: 2024-03-08, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: Aalborg University, class: OTHER, descriptionModule briefSummary: We aim to include 60 children and adolescents aged 10 to 19 years who have undergone successful treatment for leukemia or lymphoma. Based on randomization, they will either 1) commence 16 weeks of training with STEEL or 2) commence 16 weeks of circuit training. STEEL training involves exercises for major muscle groups using free weights, body weight, or tailored machines. Circuit training is structured similarly to previous training for the target group and includes exercises using body weight, exercise balls, and rings. The training takes place in local centers either with friends or with other participants in the project. Before starting participation in the project, the child/adolescent and their parents or guardians will receive information about late effects, diet, sleep, and exercise, providing guidance and support regarding the project elements. The effects of the two training modalities will be evaluated based on self-reported quality of life, muscle strength, muscle mass, bone mineral content, fitness, and markers of metabolic syndrome (BMI, waist circumference, blood pressure, and blood analysis)., conditionsModule conditions: Cancer, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: STEEL, interventions name: Circuit training, outcomesModule primaryOutcomes measure: Isometric strength, secondaryOutcomes measure: Health-related quality of life, secondaryOutcomes measure: Step counts, secondaryOutcomes measure: Caloric expenditure, secondaryOutcomes measure: Maximal dynamic strength, secondaryOutcomes measure: Bone mineral density of the lumbar spine and body composition, secondaryOutcomes measure: Grip strength and rate of force development, secondaryOutcomes measure: Muscular strength, endurance, and rate of force development, secondaryOutcomes measure: Cardiorespiratory fitness and endurance, secondaryOutcomes measure: Exercise compliance and fidelity, secondaryOutcomes measure: Adverse events, secondaryOutcomes measure: Movement-evoked pain, secondaryOutcomes measure: Satisfaction with the intervention, secondaryOutcomes measure: Blood glucose, secondaryOutcomes measure: Glycated hemoglobin (Hba1c), secondaryOutcomes measure: Insulin, secondaryOutcomes measure: Proinsulin c-peptide, secondaryOutcomes measure: Total cholesterol, secondaryOutcomes measure: High-density lipoprotein cholesterol, secondaryOutcomes measure: Low-density lipoprotein cholesterol, secondaryOutcomes measure: Very low-density lipoprotein cholesterol, secondaryOutcomes measure: Triglycerides, secondaryOutcomes measure: Glucagon, secondaryOutcomes measure: Homeostatic Model assessment for Insulin resistance score, secondaryOutcomes measure: Body Mass Index (BMI), secondaryOutcomes measure: Lean body mass, secondaryOutcomes measure: Fat mass, secondaryOutcomes measure: Android/gynoid fat distribution, secondaryOutcomes measure: Abdominal circumference, secondaryOutcomes measure: Self-reported Tanner staging, secondaryOutcomes measure: Blood pressure, eligibilityModule sex: ALL, minimumAge: 10 Years, maximumAge: 19 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Rigshospitalet, status: RECRUITING, city: Copenhagen, country: Denmark, contacts name: Martin K Fridh, role: CONTACT, email: martin.kaj.fridh@regionh.dk, geoPoint lat: 55.67594, lon: 12.56553, locations facility: Aalborg University, status: RECRUITING, city: Gistrup, zip: 9260, country: Denmark, contacts name: Henrik Riel, role: CONTACT, email: hriel@dcm.aau.dk, geoPoint lat: 56.9943, lon: 9.99085, locations facility: Odense University Hospital, status: RECRUITING, city: Odense, country: Denmark, contacts name: Mathias Rathe, role: CONTACT, email: mathias.rathe@rsyd.dk, geoPoint lat: 55.39594, lon: 10.38831, locations facility: Århus University Hospital, status: RECRUITING, city: Århus, country: Denmark, contacts name: Clara Vad, role: CONTACT, email: claravad@live.dk, geoPoint lat: 56.15674, lon: 10.21076, hasResults: False