protocolSection identificationModule nctId: NCT06275360, orgStudyIdInfo id: SPLP-002-23F, briefTitle: Repositioning Immunotherapy in VetArans With Lung Cancer, acronym: RIVAL, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2027-02-28, completionDateStruct date: 2030-03-31, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: VA Office of Research and Development, class: FED, descriptionModule briefSummary: This study is a multicenter Phase II single arm trial to assess the safety and efficacy of chemotherapy and immunotherapy followed by radiotherapy in patients with unresectable Stage III NSCLC., conditionsModule conditions: Non-Small Cell Lung Cancer, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Carboplatin, paclitaxel, and nivolumab for three cycles followed by radiotherapy followed by nivolumab (for squamous cell lung cancer) OR Carboplatin, pemetrexed, and nivolumab for three cycles followed by radiotherapy followed by nivolumab (for lung adenocarcinoma), primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 25, type: ESTIMATED, armsInterventionsModule interventions name: Nivolumab, outcomesModule primaryOutcomes measure: Progression-free survival, primaryOutcomes measure: Treatment Tolerance, secondaryOutcomes measure: Adverse Events, secondaryOutcomes measure: Best overall response rate (BOR), secondaryOutcomes measure: Overall survival, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: VA Greater Los Angeles Healthcare System, West Los Angeles, CA, status: NOT_YET_RECRUITING, city: West Los Angeles, state: California, zip: 90073-1003, country: United States, contacts name: Daniel Shin, MD, role: CONTACT, phone: 310-478-3711, email: Daniel.Shin@va.gov, contacts name: Michelle Treadwell, role: CONTACT, phone: 3104783711, phoneExt: 45003, email: Michelle.Treadwell@va.gov, geoPoint lat: 34.0464, lon: -118.44813, locations facility: VA Connecticut Healthcare System West Haven Campus, West Haven, CT, status: RECRUITING, city: West Haven, state: Connecticut, zip: 06516-2770, country: United States, contacts name: Michal Rose, MD, role: CONTACT, phone: 203-932-5711, phoneExt: 2832, email: Michal.Rose@va.gov, contacts name: Alicia Roy, role: CONTACT, phone: 2039325711, phoneExt: 3006, email: Alicia.Roy@va.gov, geoPoint lat: 41.27065, lon: -72.94705, locations facility: VA Ann Arbor Healthcare System, Ann Arbor, MI, status: RECRUITING, city: Ann Arbor, state: Michigan, zip: 48105-2303, country: United States, contacts name: Brittany M Pannecouk, BS, role: CONTACT, phone: 734-845-3966, email: brittany.pannecouk@va.gov, contacts name: Laura A Randolph, BA, role: CONTACT, phone: (734) 845-5091, email: Laura.Randolph@va.gov, contacts name: Michael D Green, role: PRINCIPAL_INVESTIGATOR, contacts name: Nithya Ramnath, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.27756, lon: -83.74088, locations facility: Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE, status: NOT_YET_RECRUITING, city: Omaha, state: Nebraska, zip: 68105-1850, country: United States, contacts name: Apar Kishor P Ganti, MD, role: CONTACT, phone: 402-346-8800, phoneExt: 3846, email: Aparkishor.Ganti@va.gov, contacts name: Anna Kellogg, role: CONTACT, phone: 4029954143, email: Anna.Kellogg@va.gov, geoPoint lat: 41.25626, lon: -95.94043, locations facility: Durham VA Medical Center, Durham, NC, status: NOT_YET_RECRUITING, city: Durham, state: North Carolina, zip: 27705-3875, country: United States, contacts name: Michael Kelley, MD, role: CONTACT, phone: 919-286-0411, phoneExt: 172199, email: Michael.Kelley6@va.gov, contacts name: Maya Robinson, role: CONTACT, phone: 9192866926, email: Maya.Robinson@va.gov, geoPoint lat: 35.99403, lon: -78.89862, locations facility: Louis Stokes VA Medical Center, Cleveland, OH, status: NOT_YET_RECRUITING, city: Cleveland, state: Ohio, zip: 44106-1702, country: United States, contacts name: Charles Nock, MD, role: CONTACT, phone: 216-791-3800, phoneExt: 64825, email: Charles.Nock@va.gov, contacts name: Margaret Titkin, role: CONTACT, phone: 2167913800, phoneExt: 36241, email: MargaretTiktin@va.gov, geoPoint lat: 41.4995, lon: -81.69541, locations facility: Hunter Holmes McGuire VA Medical Center, Richmond, VA, status: NOT_YET_RECRUITING, city: Richmond, state: Virginia, zip: 23249-0001, country: United States, contacts name: Bhaumik Patel, MD, role: CONTACT, phone: 804-675-5446, email: Bhaumik.Patel@va.gov, geoPoint lat: 37.55376, lon: -77.46026, hasResults: False