hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06355895, orgStudyIdInfo id: HCC 23-104, briefTitle: Liver Volume Variation Effect on SBRT Planning and Delivery for Upper Abdominal Malignancies, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2025-04, completionDateStruct date: 2025-04, studyFirstPostDateStruct date: 2024-04-10, lastUpdatePostDateStruct date: 2024-04-10, sponsorCollaboratorsModule leadSponsor name: University of Pittsburgh, class: OTHER, collaborators name: American College of Radiation Oncology, descriptionModule briefSummary: Standard planning constraints for liver SBRT incorporate strict dose-volume limits for normal liver parenchyma to minimize the risk of radiation-induced liver disease. The presence of diurnal and fasting/fed variations in liver volume therefore carry substantial potential for introducing errors into estimates of dose-volume distribution within normal liver tissue, as well as affecting day-to-day setup fidelity and organ alignment for treatment. This prospective study will examine how diurnal and fast-fed variations in liver volume affect treatment planning for abdominal SBRT., conditionsModule conditions: Upper Abdominal Malignancies, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: NONE, enrollmentInfo count: 17, type: ESTIMATED, armsInterventionsModule interventions name: Standardized high-carbohydrate meal, outcomesModule primaryOutcomes measure: Diurnal Difference in Liver Volumes, secondaryOutcomes measure: Difference in total liver volume, secondaryOutcomes measure: Percentage diurnal difference in liver mean dose at V5 Gy, secondaryOutcomes measure: Percentage diurnal difference in liver mean dose at V15Gy, secondaryOutcomes measure: Difference in liver mean dose at V15 Gy, secondaryOutcomes measure: Difference in liver dose at V15 Gy, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: UPMC Hillman Cancer Center, city: Pittsburgh, state: Pennsylvania, zip: 15232, country: United States, contacts name: Samantha Demko, role: CONTACT, contacts name: Brieanna Marino, role: CONTACT, contacts name: Susannah Ellsworth, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.44062, lon: -79.99589, hasResults: False
protocolSection identificationModule nctId: NCT06355882, orgStudyIdInfo id: LCOSDental, briefTitle: Patients With Low Cardiac Output Syndrome Undergoing Local Dental Anesthesia, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-08-08, primaryCompletionDateStruct date: 2024-12-01, completionDateStruct date: 2024-12-01, studyFirstPostDateStruct date: 2024-04-10, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: University of Sao Paulo General Hospital, class: OTHER, collaborators name: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior., descriptionModule briefSummary: Patients with low cardiac output syndrome requiring surgical and periodontal dental treatment will be selected to undergo the dental procedure using local dental anesthetic: 2% lidocaine with epinephrine and 2% lidocaine without vasoconstrictor. Cardiovascular events and the safety of using two cartridges (3.6 mL) will be evaluated. They will be evaluated by Holter monitoring in the period of 1 hour before, during and 1 hour after the procedure and blood pressure correction will be performed, conditionsModule conditions: Low Cardiac Output Syndrome, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, enrollmentInfo count: 29, type: ESTIMATED, armsInterventionsModule interventions name: Anesthetic infiltration, outcomesModule primaryOutcomes measure: Amount ventricular and supraventricular arrhythmia, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Instituto do Coração HCFMUSP, status: RECRUITING, city: São Paulo, zip: 05403000, country: Brazil, contacts name: Itamara LI Neves, PhD, role: CONTACT, phone: 1126615229, email: itamara@incor.usp.br, contacts name: Mariana DC Dias, role: CONTACT, phone: 19996614440, email: mariana2497@gmail.com, contacts name: Itamara LI Neves, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -23.5475, lon: -46.63611, hasResults: False
protocolSection identificationModule nctId: NCT06355869, orgStudyIdInfo id: s65337, briefTitle: Repeatability of Gait Deviations in Children With Cerebral Palsy, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-08-17, primaryCompletionDateStruct date: 2023-05-31, completionDateStruct date: 2023-05-31, studyFirstPostDateStruct date: 2024-04-10, lastUpdatePostDateStruct date: 2024-04-15, sponsorCollaboratorsModule leadSponsor name: Universitaire Ziekenhuizen KU Leuven, class: OTHER, descriptionModule briefSummary: Three-dimensional gait analysis (3DGA) is the 'gold standard' for measurement and description of gait. Gait variability can arise from intrinsic and extrinsic factors and may vary between walking conditions. This study aimed to define the inter-trial (intrinsic) and inter-session (extrinsic) repeatability in gait analysis data of children with CP who were walking in four conditions, namely barefoot or with ankle-foot orthosis, and overground or treadmill., conditionsModule conditions: Spastic Cerebral Palsy, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 10, type: ACTUAL, armsInterventionsModule interventions name: repeated 3D gait-analysis, outcomesModule primaryOutcomes measure: The standard error of measurement (SEM) of the continuous kinematic gait waveforms, primaryOutcomes measure: The intra-class correlation (ICC) of the gait indices, primaryOutcomes measure: The standard error of measurement (SEM) of the continuous kinetic gait waveforms, primaryOutcomes measure: The standard error of measurement (SEM) of the gait indices, eligibilityModule sex: ALL, minimumAge: 6 Years, maximumAge: 17 Years, stdAges: CHILD, contactsLocationsModule locations facility: UZ Leuven, city: Leuven, state: Vlaams-Brabant, zip: 3000, country: Belgium, geoPoint lat: 50.87959, lon: 4.70093, hasResults: False
protocolSection identificationModule nctId: NCT06355856, orgStudyIdInfo id: ACH-PNT-04(01/22), briefTitle: Efficacy/ Safety of DNN.22.17.036 in Male Patients With Pattern Hair Loss, acronym: CAPELLI, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2025-05, completionDateStruct date: 2025-05, studyFirstPostDateStruct date: 2024-04-10, lastUpdatePostDateStruct date: 2024-04-10, sponsorCollaboratorsModule leadSponsor name: Ache Laboratorios Farmaceuticos S.A., class: INDUSTRY, descriptionModule briefSummary: Evaluation of the efficacy and safety of DNN.22.17.036 versus 10573048700 in the treatment of male pattern hair loss., conditionsModule conditions: Alopecia, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 196, type: ESTIMATED, armsInterventionsModule interventions name: DNN.22.17.036, interventions name: 10573048700, outcomesModule primaryOutcomes measure: Percentage variation of hairs in the hair loss phase, eligibilityModule sex: MALE, minimumAge: 25 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06355843, orgStudyIdInfo id: SXY, briefTitle: Clinical Applications of Integrated PET/MR and PET/CT in the Diagnosis and Treatment of Prostate Cancer., statusModule overallStatus: SUSPENDED, startDateStruct date: 2022-04-28, primaryCompletionDateStruct date: 2023-09-30, completionDateStruct date: 2027-03-31, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: The First Affiliated Hospital of Anhui Medical University, class: OTHER, collaborators name: National Natural Science Foundation of China, descriptionModule briefSummary: The goal of this study type: observational study (prospective study) is to study prostate cancer occurrence and recurrence, to specifically identify and localize tumor foci at the molecular level at an early stage, to evaluate the prognosis of patients, and to accurately stage not only intermediate- and high-risk prostate cancer patients with a primary diagnosis, but also detect recurrent foci in patients with biochemical recurrence, to restage those who have developed metastases, to assess tumor load, and to ultimately assist in determining the personalized treatment plans. The main question it aims to answer is whether 68Ga-PSMA PET/CT (PET/MR) examination is beneficial for assessing the* Accurate staging of patients with intermediate- and high-risk prostate cancer at first diagnosis;* Detecting recurrent lesions in patients with recurrent tumors for re-staging;* Assessment of tumor load;* Assessment of patient prognosis. Participants will sign an informed consent form, undergo 68Ga-PSMA PET/CT (PET/MR) before surgery or biopsy, and have regular follow-up after obtaining pathological results of surgical resection or puncture biopsy, 6 weeks after surgery or biopsy, and then every 3 months; the follow-up will include: blood PSA, whole-body bone imaging, etc., conditionsModule conditions: Prostate Cancer, conditions: Pet-ct, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: 68Ga-PSMA, outcomesModule primaryOutcomes measure: Measuring the value of 68Ga-PSMA PET/MRI in the diagnosis and staging of primary prostate cancer and comparing it with mp-MRI and PET/CT, primaryOutcomes measure: Exploring whether 68Ga-PSMA PET/MRI can be used as a method for diagnostic efficacy, eligibilityModule sex: MALE, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: First affiliated hospital of anhui university, city: Hefei, state: Anhui, zip: 230032, country: China, geoPoint lat: 31.86389, lon: 117.28083, hasResults: False
protocolSection identificationModule nctId: NCT06355830, orgStudyIdInfo id: RETimaging4iAMD, briefTitle: Intermediate Age-related Macular Degeneration - Multimodal Analysis and Longitudinal Study, acronym: Imaging4iAMD, statusModule overallStatus: RECRUITING, startDateStruct date: 2019-01-02, primaryCompletionDateStruct date: 2025-06, completionDateStruct date: 2026-06, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Universidade Nova de Lisboa, class: OTHER, collaborators name: iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, UNL, collaborators name: Centro Hospitalar de Lisboa Central EPE, Lisboa, Portugal, collaborators name: Centro Hospitalar Universitário de São João, Porto, Portugal, descriptionModule briefSummary: Study: observational prospective clinical study. Study population: Subjects over 55 years old with drusen secondary to intermediate AMD.Recruitment: at the Medical Retinal Consultation from the Ophthalmology Department of CHULC.Primary outcome: Identifying imaging predictors of iAMD progression., conditionsModule conditions: Age-Related Macular Degeneration, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 150, type: ESTIMATED, armsInterventionsModule interventions name: Orthoptic assessment (Outcome measure), outcomesModule primaryOutcomes measure: Change in incomplete retinal pigment epithelial and outer retinal atrophy (iRORA) from baseline, primaryOutcomes measure: Change in Drusen morphology from baseline, primaryOutcomes measure: Change in Subfoveal drusen area from baseline, primaryOutcomes measure: Change in other drusen area from baseline, primaryOutcomes measure: Change in Drusen reflectivity from baseline, primaryOutcomes measure: Change in other Drusen homogeneity from baseline, primaryOutcomes measure: Change in ellipsoid zone disruption from baseline, primaryOutcomes measure: Change in Drusen homogeneity from baseline, primaryOutcomes measure: Change in hyperreflective foci from baseline, primaryOutcomes measure: Change in hyperreflective foci location (within 500-μm disc area) from baseline, primaryOutcomes measure: Change in hyperreflective foci association to drusen from baseline, primaryOutcomes measure: Progression to Moderate Vision Loss, primaryOutcomes measure: Geographic Atrophy (GA) Growth Rate, secondaryOutcomes measure: Progression to Advanced AMD according to international classification/grading system, eligibilityModule sex: ALL, minimumAge: 55 Years, maximumAge: 95 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Ophthalmology Service, Centro Hospitalar de Lisboa Central EPE, status: RECRUITING, city: Lisbon, zip: 1150-199, country: Portugal, contacts name: Rita Flores, MD, role: CONTACT, phone: 00351218841000, phoneExt: 21355, email: ritamariaflores@gmail.com, geoPoint lat: 38.71667, lon: -9.13333, hasResults: False
protocolSection identificationModule nctId: NCT06355817, orgStudyIdInfo id: HS25941, briefTitle: Distraction Techniques in Periocular Anesthesia: Tapping vs Vibration, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-09-21, primaryCompletionDateStruct date: 2024-03-19, completionDateStruct date: 2024-03-19, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: University of Manitoba, class: OTHER, collaborators name: Winnipeg Regional Health Authority, descriptionModule briefSummary: To compare the efficacy of topical tapping vs vibration in lowering pain scores for periocular anesthesia injections., conditionsModule conditions: Anesthetics, Local, conditions: Blepharoplasty, conditions: Age-Related Ptosis, conditions: Adult, conditions: Humans, conditions: Lidocaine, conditions: Ophthalmologic Surgical Procedure, conditions: Vibration, conditions: Surgery, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, interventionModelDescription: Each patient will receive both interventions and serve as their own comparator., primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: The participant and surgeon was not made aware of which intervention the participant would receive first until the time of the procedure. Randomization was made at the time of the procedure., whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, enrollmentInfo count: 80, type: ACTUAL, armsInterventionsModule interventions name: Vibration, interventions name: Tapping, outcomesModule primaryOutcomes measure: Pain Reduction in Tapping vs Vibration distraction techniques in peri-ocular local anesthesia, secondaryOutcomes measure: Difference in Pain Reduction, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Misericordia Health Centre, city: Winnipeg, state: Manitoba, zip: R3C 1A2, country: Canada, geoPoint lat: 49.8844, lon: -97.14704, hasResults: False
protocolSection identificationModule nctId: NCT06355804, orgStudyIdInfo id: STUDY2023-1565, briefTitle: Lifestyle Physical Activity Intervention for Persons Newly Diagnosed With Multiple Sclerosis, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-22, primaryCompletionDateStruct date: 2025-04-22, completionDateStruct date: 2025-04-22, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: University of Illinois at Chicago, class: OTHER, descriptionModule briefSummary: The overall objective of the current study is to determine the efficacy of a 16-week remotely delivered lifestyle behavioral intervention compared with a control condition (i.e., waitlist control) in persons newly diagnosed with MS (disease duration ≤ 2 years).Specific Aim 1: To evaluate the changes in self-report and device-measured physical activity after the 16-week remotely delivered physical activity behavior change intervention compared with a control condition (i.e., waitlist control) in persons who have diagnosed with MS within the past two years. The investigators hypothesize that the 16-week behavior change intervention will yield greater improvements in physical activity levels than the control condition immediately after the intervention.Specific Aim 2: To investigate the efficacy of the 16-week, remotely delivered physical activity behavior change intervention compared with the control condition for improvements in fatigue, depression, anxiety, and QoL in persons newly diagnosed with MS. The investigators hypothesize that there will be beneficial effects on the symptoms and QoL outcomes immediately after the physical activity intervention compared with minimal changes in the control condition., conditionsModule conditions: Multiple Sclerosis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Physical activity condition, interventions name: Waitlist condition, outcomesModule primaryOutcomes measure: Physical Activity Behavior, primaryOutcomes measure: Physical Activity Behavior, primaryOutcomes measure: Physical Activity Level (Light physical activity), primaryOutcomes measure: Physical Activity Level (Moderate-to-vigorous physical activity), primaryOutcomes measure: Physical Activity Level (Daily step count), secondaryOutcomes measure: Health-related quality of Life, secondaryOutcomes measure: Health-related Quality of Life, secondaryOutcomes measure: Fatigue Severity, secondaryOutcomes measure: Depressive Symptoms, secondaryOutcomes measure: Anxiety, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06355791, orgStudyIdInfo id: PDPROJ-4-TP-001-23, briefTitle: The Stability Study, acronym: STABILITY, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2024-04-15, primaryCompletionDateStruct date: 2025-04-30, completionDateStruct date: 2025-09-30, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Spinal Simplicity LLC, class: INDUSTRY, descriptionModule briefSummary: The studied indication is degenerative conditions of the lumbar spine resulting in back pain with lower extremity symptoms and neurogenic claudication.The purpose of this study is to evaluate the effectiveness and safety of instrumented posterior arthrodesis using the Spinal Simplicity Minuteman G5 MIS Fusion Plate and bone graft material in patients with degenerative conditions of the lumbar spine resulting in chronic low back pain with lower extremity symptoms and concurrent neurogenic claudication., conditionsModule conditions: Lumbar Spinal Stenosis, conditions: Spondylolisthesis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 150, type: ESTIMATED, armsInterventionsModule interventions name: Minuteman G5, outcomesModule primaryOutcomes measure: NRS Back and Leg, primaryOutcomes measure: ODI, primaryOutcomes measure: PROMIS 29 2.0, secondaryOutcomes measure: 12 Month Fusion Assessment, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Kansas University Medical Center, city: Kansas City, state: Kansas, zip: 66160, country: United States, geoPoint lat: 39.11417, lon: -94.62746, hasResults: False
protocolSection identificationModule nctId: NCT06355778, orgStudyIdInfo id: HUM00234185, secondaryIdInfos id: 1R01DA056415, type: NIH, link: https://reporter.nih.gov/quickSearch/1R01DA056415, briefTitle: Adversity, Brain and Opioid Use Study, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2028-04, completionDateStruct date: 2028-04, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: University of Michigan, class: OTHER, collaborators name: National Institute on Drug Abuse (NIDA), descriptionModule briefSummary: The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and healthy adults that do not have an Opioid Use Disorder and are not taking buprenorphine., conditionsModule conditions: Opioid Use Disorder, conditions: Healthy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 315, type: ESTIMATED, armsInterventionsModule interventions name: Magnetic Resonance Imaging (MRI), interventions name: Computer Tasks, outcomesModule primaryOutcomes measure: Differences in Blood Oxygen Level Dependent (BOLD) signal in the hippocampus, primaryOutcomes measure: Differences in Hippocampal (Hpc) volume, primaryOutcomes measure: Differences in hippocampal circuit connectivity, primaryOutcomes measure: Differences in performance, primaryOutcomes measure: Differences in performance, primaryOutcomes measure: Differences in threat reactivity measured via skin conductance response (SCR), primaryOutcomes measure: Differences in threat reactivity measured via skin conductance response (SCR), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: University of Michigan, city: Ann Arbor, state: Michigan, zip: 48109, country: United States, contacts name: Mariya Churina, role: CONTACT, email: AdversityBrainOUD@med.umich.edu, contacts name: Elizabeth Duval, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.27756, lon: -83.74088, hasResults: False