hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06372470, orgStudyIdInfo id: CLM-HTN-005, briefTitle: Personalised Dose Optimisation of Zestril Supported by the Digital Blood Pressure Diary in a Primary Care Environment in England: Pragmatic Observational Pilot Study for Remote Hypertension Treatment, acronym: OptiZest, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-15, primaryCompletionDateStruct date: 2024-08-31, completionDateStruct date: 2024-08-31, studyFirstPostDateStruct date: 2024-04-18, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Closed Loop Medicine, class: INDUSTRY, collaborators name: Pharmanovia, descriptionModule briefSummary: A pragmatic observational proof-of-concept study which aims to determine the feasibility of a remote titration clinic, assisted by home blood pressure monitoring and digital solutions, and assess its impact on real-world outcomes. By incorporating home blood pressure monitoring, the study seeks to offer a promising solution for personalised drug titration and self-management, potentially enhancing patient outcomes while optimising Zestril utilisation, conditionsModule conditions: Uncomplicated Hypertension, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Zestril, outcomesModule primaryOutcomes measure: Achieving target Home Blood Pressure, secondaryOutcomes measure: Reduction in systolic blood pressure (SBP), secondaryOutcomes measure: Reduction in diastolic blood pressure (DBP), secondaryOutcomes measure: The time to achieve BP Control (BPC), secondaryOutcomes measure: Patient daily adherence to prescribed medication, secondaryOutcomes measure: Adherence to collecting data using the electronic BP diary, secondaryOutcomes measure: Patients' thoughts and feelings about BP/treatment, secondaryOutcomes measure: Discontinuation of Zestril due to unwanted side effects, secondaryOutcomes measure: Number and type of spontaneously reported unwanted side effects, secondaryOutcomes measure: User experience and feasibility of the blood pressure digital diary, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Norwich Health Centre, status: RECRUITING, city: Norwich, country: United Kingdom, contacts name: Serge Engamba, MD, role: CONTACT, phone: 01603987074, email: serge.engamba@nhs.net, contacts name: Marc Buckingham, role: CONTACT, email: marc.buckingham@nhs.net, geoPoint lat: 52.62783, lon: 1.29834, hasResults: False
protocolSection identificationModule nctId: NCT06372444, orgStudyIdInfo id: 995725, briefTitle: Mechanisms of Acute Kidney Injury in Severe Infections, acronym: PET-AKI, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2026-04-03, completionDateStruct date: 2026-06-30, studyFirstPostDateStruct date: 2024-04-18, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Uppsala University Hospital, class: OTHER, descriptionModule briefSummary: Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations., conditionsModule conditions: Sepsis, conditions: AKI - Acute Kidney Injury, conditions: Positron Emission Tomography (PET), designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 15, type: ESTIMATED, armsInterventionsModule interventions name: Positron emission tomography (PET), outcomesModule primaryOutcomes measure: Renal perfusion in patients with sepsis and acute kidney injury (AKI) measured by 15O-labeled water in dynamic positron emission tomography (PET), primaryOutcomes measure: Presence of neutrophil elastase in the kidneys in patients with sepsis and acute kidney injury (AKI) by 11C-GW457427 measured with dynamic positron emission tomography (PET), eligibilityModule sex: ALL, minimumAge: 30 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06372431, orgStudyIdInfo id: D1843R00360, briefTitle: PRospectIve ObseRvatIonal mulTicenter Study of Patients With Arterial hYpertension and CKD in the Population of Russia, acronym: PRIORITY-CKD, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-24, primaryCompletionDateStruct date: 2025-10-31, completionDateStruct date: 2025-10-31, studyFirstPostDateStruct date: 2024-04-18, lastUpdatePostDateStruct date: 2024-04-18, sponsorCollaboratorsModule leadSponsor name: AstraZeneca, class: INDUSTRY, descriptionModule briefSummary: This study is a multi-centre, non-interventional, observational, prospective study with retrospective analysis. The main purpose of the study is to describe the rate of CKD diagnosis in patients with AH and CKD markers. This study will include 10 000 adult outpatients with arterial hypertension, who have one or more Chronic Kidney Disease laboratory markers (without recorded CKD diagnosis prior to enrolment) and have no diabetes mellitus or chronic heart failure, who are monitored and treated by cardiologists or internal medicine specialists in approximately 50 outpatient sites in about 20 regions in Russia.This observational study does not provide for any diagnostic and therapeutic procedures other than those used in routine practice., conditionsModule conditions: Arterial Hypertension, Chronic Kidney Disease, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: OTHER, enrollmentInfo count: 10000, type: ESTIMATED, outcomesModule primaryOutcomes measure: To describe the rate of CKD diagnosis in patients with AH and CKD markers., secondaryOutcomes measure: To describe demographic and clinical characteristics of patients with AH and CKD markers, secondaryOutcomes measure: To describe clinical characteristics of patients with AH and diagnosed CKD during this study (on Visit 1 or Visit 2) and profile of routine therapy before and after CKD diagnosis, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06372418, orgStudyIdInfo id: KEMRI/SERU/CGMR-C/238/4326, briefTitle: Providing Breastfeeding Support After Discharge From Hospital to Improve Growth and Development of Malnourished Infants, acronym: IBAMI-2, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2027-02, completionDateStruct date: 2027-02, studyFirstPostDateStruct date: 2024-04-18, lastUpdatePostDateStruct date: 2024-04-18, sponsorCollaboratorsModule leadSponsor name: University of Oxford, class: OTHER, descriptionModule briefSummary: The current guidelines used to manage malnutrition among infants aged below 6 months (u6m) recommend that infants admitted to hospital with malnutrition be supported to reestablish exclusive breastfeeding before discharge. Studies have shown that reestablishing exclusive breastfeeding among infants being treated for acute malnutrition is possible. However, follow-up of the infants after discharge has revealed poor growth raising questions about what happens to infant feeding practices after discharge and whether providing breastfeeding support to mothers after discharge would help improve the recovery and growth of their infants.Providing a package of home-based care with breastfeeding support to mothers of infants u6m recovering from acute malnutrition has the potential to improve the retention of exclusive breastfeeding and lead to enhanced infant growth and survival. To date, no such post-discharge package of care is available in Kenya or other lower and meddle income countries (LMICs). The aim of this study is to apply participatory, qualitative and quantitative approaches to develop and evaluate the impact of a post-discharge package of care on the growth and development of acutely ill malnourished infants after discharge from hospital., conditionsModule conditions: Malnutrition, Infant, conditions: Breastfeeding, Exclusive, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized Control Trial:Participants will be randomized to either receive Breastfeeding support intervention (BFSI) or standard of care., primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, maskingDescription: Fieldworkers collecting endpoint data at 6 months of age will be blinded to group allocation to avoid any bias subject to knowledge of group allocation., whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 250, type: ESTIMATED, armsInterventionsModule interventions name: Breastfeeding peer support intervention, interventions name: Standard Care, outcomesModule primaryOutcomes measure: Weight gain, secondaryOutcomes measure: Morbidity, secondaryOutcomes measure: Mortality, eligibilityModule sex: ALL, minimumAge: 4 Weeks, maximumAge: 12 Weeks, stdAges: CHILD, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06372392, orgStudyIdInfo id: 1.0, briefTitle: Universal Fixed Meal Boluses Usage in Patients With Medtronic Minimed 780G Pumps, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-10-10, primaryCompletionDateStruct date: 2024-06-10, completionDateStruct date: 2024-12-01, studyFirstPostDateStruct date: 2024-04-18, lastUpdatePostDateStruct date: 2024-04-18, sponsorCollaboratorsModule leadSponsor name: Tartu University Hospital, class: OTHER, collaborators name: Estonia Research Council, descriptionModule briefSummary: Cross-over study of 20 pediatric patients (age 7-19) randomized to the group receiving universal fixed meal boluses coefficients (300/TDD for breakfast and 400/TDD other meal) or to the group with individualized coefficients for the period of 14 days with consecutive analysis of the results from Carelink Raport., conditionsModule conditions: Type1diabetes, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Universal meal coefficient utilization, outcomesModule primaryOutcomes measure: Time in range (TIR), secondaryOutcomes measure: TBR, secondaryOutcomes measure: TAR, secondaryOutcomes measure: auto-corrections %, secondaryOutcomes measure: coefficient of variability, eligibilityModule sex: ALL, minimumAge: 7 Years, maximumAge: 19 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: TartuUH, status: RECRUITING, city: Tartu, state: Tartumaa, zip: 50406, country: Estonia, contacts name: Aleksandr Peet, role: CONTACT, phone: 5532256, email: aleksandr.peet@kliinikum.ee, geoPoint lat: 58.38062, lon: 26.72509, hasResults: False
protocolSection identificationModule nctId: NCT06372379, orgStudyIdInfo id: 8780_UC2, briefTitle: Development of a Multipurpose Dashboard to Monitor the Situation of Emergency Departments, acronym: eCREAM-UC2, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-09, primaryCompletionDateStruct date: 2025-01, completionDateStruct date: 2027-09, studyFirstPostDateStruct date: 2024-04-18, lastUpdatePostDateStruct date: 2024-04-18, sponsorCollaboratorsModule leadSponsor name: Mario Negri Institute for Pharmacological Research, class: OTHER, collaborators name: Astir S.r.l., collaborators name: Orobix Life S.r.l., collaborators name: Fondazione Bruno Kessler, descriptionModule briefSummary: An emergency department (ED) is a healthcare service that provides the first clinical assessment and treatment to patients with various acute conditions. These departments, however, are often overwhelmed by the large volume of patients. As a consequence, ED crowding has become a global concern and has been correlated to reduced timeliness and effectiveness of care and increased patient mortality. Concerning input, 20% to 30% of patients are brought to the ED by ambulance; the remaining are self-presenting for the vast majority. Notably, non-urgent conditions characterize a high proportion of all ED visits worldwide, and almost all of these visits involve self-presenting patients. Increasing the awareness of these patients about the mandate of EDs and the real-time situation of the neighboring emergency departments has the potential to reduce the self-presentation of patients with minor, non-urgent conditions. Such patient empowerment can be achieved through a dashboard. Concerning throughput, working in the ED requires emergency physicians and nurses to treat many patients at once while maintaining situational awareness of the surroundings. This is especially true for the head of the department, but it also holds for all physicians. It can be crucial, for example, for physicians to know if there is a bottleneck in the flow of the entire patient care process, such as a particularly high average waiting time for radiology reporting or cardiologic consultation. The availability of this information allows countermeasures to be put in place to regain efficiency. All this can be achieved through dedicated dashboards automatically fed from various information system. In addition, appropriate dashboards also enable health policymakers to monitor specific epidemiological phenomena, such as the emergence of certain infectious diseases, in a timely manner., conditionsModule conditions: Emergency Medicine, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 162000, type: ESTIMATED, armsInterventionsModule interventions name: no intervention, outcomesModule primaryOutcomes measure: Daschboards, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06372366, orgStudyIdInfo id: Dental caries and vit.difiency, briefTitle: Relationship Between Vitamins Deficiency and Caries Experience Among a Group of Egyptian Children, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-07-15, primaryCompletionDateStruct date: 2024-10-15, completionDateStruct date: 2025-12-15, studyFirstPostDateStruct date: 2024-04-18, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Cairo University, class: OTHER, descriptionModule briefSummary: Dental caries is a worldwide condition characterized by localized destruction of dental hard tissue by acidic by-products from bacterial fermentation of dietary carbohydrates . Dental caries is considered to be the single most common chronic childhood disease, and its prevalence is thought to have increased recently., conditionsModule conditions: Dental Caries, conditions: Vitamin Deficiency, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 2, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Caries prevalence, eligibilityModule sex: ALL, minimumAge: 3 Years, maximumAge: 5 Years, stdAges: CHILD, hasResults: False
protocolSection identificationModule nctId: NCT06372353, orgStudyIdInfo id: 777, briefTitle: The Effect Of Baduanjin Exercises In Patients With Idiopathic Pulmonary Fibrosis, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-06-01, primaryCompletionDateStruct date: 2023-05-24, completionDateStruct date: 2023-06-06, studyFirstPostDateStruct date: 2024-04-18, lastUpdatePostDateStruct date: 2024-04-18, sponsorCollaboratorsModule leadSponsor name: Marmara University, class: OTHER, descriptionModule briefSummary: Introduction and Objectives:IPF, characterized by shortness of breath and progressive deterioration in lung function.Baduanjin (BJ) is a mindbody health exercise that combines physical exercise with psychological properties to maximize both physical and mental health.The aim of the study is to investigate the effectiveness of these exercises in patients with IPF and to present an alternative in terms of the applicability of BJ exercises as a new treatment methodMethods: 28 volunteers were invited to the study.These patients were randomly divided into 2 groups.The subjects in the exercise group were given 24 sessions of supervised online BJ exercise training, 3 days a week, for 8 weeks. The patients included in the control group did not receive any training during the 8 week period, conditionsModule conditions: Pulmonary Fibrosis, Idiopathic, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 28, type: ACTUAL, armsInterventionsModule interventions name: Baduanjin Exercise, outcomesModule primaryOutcomes measure: Functional capacity, primaryOutcomes measure: Pulmonary Function Tests, primaryOutcomes measure: Pulmonary Function Tests, primaryOutcomes measure: Pulmonary Function Tests, primaryOutcomes measure: Pulmonary Function Tests, primaryOutcomes measure: Respiratory muscle strength, primaryOutcomes measure: Respiratory muscle strength, primaryOutcomes measure: St. George's Respiratory Questionnaire, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: İstanbul University - Cerrahpaşa, city: Istanbul, state: Fatih, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06372327, orgStudyIdInfo id: 73468, briefTitle: Move Often eVery Day 2.0, acronym: MOVD, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2025-05, completionDateStruct date: 2026-07, studyFirstPostDateStruct date: 2024-04-18, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Stanford University, class: OTHER, descriptionModule briefSummary: The purpose of this study is to assess a novel, widely-accessible intervention to both promote active breaks from work and improve cognitive and psychological performances at work in motivationally-accessible bouts. This will be done by interrupting prolonged sitting with 1-4 short (1-4 minutes), moderate-to-vigorous physical activity (MVPA) bouts with no equipment, and simple video-based instructions. The short bouts will be referred to as "exercise snacks." In this proposed exercise snacks intervention, investigators explicitly target a population with sedentary jobs due to the generalizability., conditionsModule conditions: Exercise, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: FACTORIAL, interventionModelDescription: This will be a 2 (Exercise snack number) x 2 (Exercise snack length) factorial design., primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Daily Exercise Snacks, outcomesModule primaryOutcomes measure: Number of self-reported exercise snack breaks at work at week 7, primaryOutcomes measure: Number of self-reported exercise snack breaks at work at week 18, primaryOutcomes measure: Number of self-reported exercise snack breaks at work at week 30 during follow-up, secondaryOutcomes measure: Liking of exercise snacks, eligibilityModule sex: FEMALE, minimumAge: 30 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Stanford University School of Medicine, city: Stanford, state: California, zip: 94305-7240, country: United States, geoPoint lat: 37.42411, lon: -122.16608, hasResults: False
protocolSection identificationModule nctId: NCT06372314, orgStudyIdInfo id: 1000081221, briefTitle: Isoleucine, Leucine, Valine and Tryptophan Requirements in TPN Fed Neonates, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-08, primaryCompletionDateStruct date: 2027-12, completionDateStruct date: 2027-12, studyFirstPostDateStruct date: 2024-04-18, lastUpdatePostDateStruct date: 2024-04-18, sponsorCollaboratorsModule leadSponsor name: The Hospital for Sick Children, class: OTHER, descriptionModule briefSummary: This project will be conducted in 2 hospitals in Brazil to assess the requirements for four essential amino acids in TPN fed neonates. Using the Carbon Oxidation method (indicator amino oxidation and direct amino acid oxidation method), the investigators will determine the requirement of each of the 4 amino acids.The investigators will determine the requirement for Isoleucine, Leucine, Valine and Tryptophan. The investigators will recruit 18- 20 babies per amino acid study. Breath and urine samples will be collected to determine the oxidation of the indicator amino acid. The response of the indicator amino acid to changes in intake of the test amino acid (isoleucine, leucine, valine and tryptophan) will be analyzed by bi-phase linear mixed effect model to determine the breakpoint or mean requirement for each amino acid. It is hypothesized that the requirement for isoleucine, leucine, valine and tryptophan will be at least 50% lower than what is currently available in commercial solutions used for TPN feeding of neonates., conditionsModule conditions: Stable Neonates Receiving Total Parenteral Nutrition (TPN), designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Total parenteral nutrition (TPN): this is total nutrition provided by central vein., outcomesModule primaryOutcomes measure: Amino acid oxidation using a labelled amino acid., eligibilityModule sex: ALL, minimumAge: 1 Day, maximumAge: 28 Days, stdAges: CHILD, contactsLocationsModule locations facility: Hospital de Caridade Dr. Astrogildo de Azevedo, and University Hospital of Santa Maria, Santa Maria, Brazil, city: Santa Maria, country: Brazil, contacts name: Ivo Dr Prola, MD, PhD, role: CONTACT, phone: 6477815786, email: iprolla@gmail.com, contacts name: Beatriz Dr Porto, MD, role: CONTACT, phone: 6475002171, email: bsilveiraporto@gmail.com, geoPoint lat: -29.68417, lon: -53.80694, hasResults: False