hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06272955, orgStudyIdInfo id: H-54417, briefTitle: LONG TERM EFFECTS OF SPINAL CORD STIMULATION, acronym: SCS for FOG OL, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2024-01-04, primaryCompletionDateStruct date: 2025-06-30, completionDateStruct date: 2025-06-30, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Nora Vanegas, class: OTHER, descriptionModule briefSummary: Parkinson Disease (PD) patients experience a variety of motor issues such as walking difficulties, loss of balance, and freezing while walking, which impacts their quality of life. Some symptoms, like freezing of gait (FOG), do not respond to medications typically used to treat PD. Current surgical procedures used to alleviate PD symptoms also do not always improve FOG. Since many traditional therapies have failed for the treatment of FOG, researchers have proposed the use of newer treatments. Recent research in animal models and clinical human data using Spinal Cord Stimulation (SCS) has produced promising results, specifically showing improvement in FOG with the use of SCS in patients with PD.The purpose of this study is to explore the long-term motor and non-motor effects of SCS in PD patients after completing participation on H-49023. The investigators hypothesize that SCS significantly decreases FOG episodes in patients with PD.1. Assess the long-term safety, tolerability and preliminary evidence of effectiveness of upper thoracic spinal cord stimulation for freezing of gait in Parkinson's (PD) patients.2. Allowing patients to choose between the two SCS programming paradigms based on their motor, nonmotor and quality of life measures in PD patients with freezing of gait., conditionsModule conditions: Parkinson Disease, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: PROSPECTIVE, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: Spinal Cord Stimulator (SCS), outcomesModule primaryOutcomes measure: Safety and Tolerability, secondaryOutcomes measure: New Freezing of Gait Questionnaire (NFOG-Q) score, secondaryOutcomes measure: Gait and Falls Questionnaire (GFQ), secondaryOutcomes measure: MDS-UPDRS score, secondaryOutcomes measure: Timed Up and Go test (TUG), secondaryOutcomes measure: Timed 10-meter walk (T10MW), secondaryOutcomes measure: Mini-Mental State Examination (MMSE), secondaryOutcomes measure: Montreal Cognitive Assessment Scale (MoCA), secondaryOutcomes measure: Beck Depression Inventory (BDI-2), secondaryOutcomes measure: Beck Anxiety Inventory (BAI), secondaryOutcomes measure: Parkinson's Disease Questionnaire - 39 (PDQ39), secondaryOutcomes measure: Non-Motor Symptoms Scale (NMSS), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Baylor College of Medicine, city: Houston, state: Texas, zip: 77005, country: United States, geoPoint lat: 29.76328, lon: -95.36327, hasResults: False
protocolSection identificationModule nctId: NCT06272929, orgStudyIdInfo id: behcet and vascular, briefTitle: Serum Elafin and Vascular Affection in Behcet Disease, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-03-01, completionDateStruct date: 2025-04-01, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: To measure the level of serum elafin in patients with BD. To assess the relation between serum elafin levels and disease activity. To evaluate the vascular complications in BD and determine their relationship with disease activity.To assess the correlation between serum elafin and vascular affection and their relation with disease activity., conditionsModule conditions: Behcet Disease and Vascular Affection, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: RETROSPECTIVE, enrollmentInfo count: 90, type: ESTIMATED, armsInterventionsModule interventions name: doppler ultrasound, outcomesModule primaryOutcomes measure: Measuring the level of serum Elafin in patients with BD in comparison to healthy participants., eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06272916, orgStudyIdInfo id: Effect drugs on headache inCS, briefTitle: Comparison of the Effect of Aminophylline, Magnesium Sulphate and Placebo in Prevention of Post Dural Puncture Headache in Parturient Undergoing Caesarean Section., statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2025-04, completionDateStruct date: 2025-06, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: This study will be conducted to better comprehend the effect of aminophylline in comparison to magnesium sulphate on preventing and/or treating PDPH., conditionsModule conditions: Post-Dural Puncture Headache, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 630, type: ESTIMATED, armsInterventionsModule interventions name: Aminophylline, magnesium sulphate and placebo, outcomesModule primaryOutcomes measure: Effect of the study drugs on the incidence and severity of PDPH, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 35 Years, stdAges: ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06272903, orgStudyIdInfo id: MBRU IRB-2023-228, briefTitle: Effect of Benzocaine 20% Topical Anesthesia on Pain Levels When Placing Separators in Children Receiving Hall Technique Crowns, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2024-09, completionDateStruct date: 2024-12, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Mohammed Bin Rashid University of Medicine and Health Sciences, class: OTHER, descriptionModule briefSummary: The goal of this RCT is to investigate the immediate effect of benzocaine 20% topical anesthesia on initial pain and discomfort levels associated with the placement of elastomeric orthodontic separators in children who are receiving Hall Technique crowns on primary molars, among children who have attended the Pediatric Dentistry Department, Dubai Dental Hospital (DDH), Mohammed Bin Rashid University (MBRU) in Dubai, the United Arab Emirates (UAE)., conditionsModule conditions: Effect of Benzocaine on Pain, designModule studyType: INTERVENTIONAL, phases: EARLY_PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 32, type: ESTIMATED, armsInterventionsModule interventions name: 20% benzocaine, topical anesthetic, interventions name: Children's Toothpaste, outcomesModule primaryOutcomes measure: Immediate Pain Levels, secondaryOutcomes measure: Patient Satisfaction During Procedure, eligibilityModule sex: ALL, minimumAge: 4 Years, maximumAge: 10 Years, stdAges: CHILD, contactsLocationsModule locations facility: Mohammed Bin Rashid University Of Medicine and Health Sciences, city: Dubai, country: United Arab Emirates, contacts name: Iyad Hussein, role: CONTACT, phone: 971564715509, email: iyad.hussein@mbru.ac.ae, contacts name: Simran Kaur Sura, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 25.0657, lon: 55.17128, hasResults: False
protocolSection identificationModule nctId: NCT06272890, orgStudyIdInfo id: GiresunU, briefTitle: THE EFFECT OF MOTIVATIONAL INTERVIEWING ON NURSING STUDENTS WITH SOCIAL ANXIETY, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-20, primaryCompletionDateStruct date: 2024-05-20, completionDateStruct date: 2024-07-20, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Gazi University, class: OTHER, descriptionModule briefSummary: Studies support the idea that people diagnosed with social anxiety disorder score significantly lower on self-acceptance than healthy controls, and that self-compassion is inversely related to anxiety. Motivational interviewing has been shown to improve treatment outcomes as well as predict higher self-compassion and reduced resistance among participants.It also has the ability to increase the effectiveness of motivational interviewing as an intervention with perpetrators of intimate partner violence, promoting readiness for change and progression through stages of change. In this context, this study aims to examine the effect of motivational interviewing on social anxiety level, dating violence and self-compassion in nursing students with social anxiety., conditionsModule conditions: Motivation, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: The research was planned as a randomized controlled experimental study in a two-center parallel group pretest-posttest design., primaryPurpose: OTHER, maskingInfo masking: SINGLE, maskingDescription: In order to prevent detection bias in the study, all measurements will be made using an online survey form. In order to prevent reporting bias, the data obtained from the research will be coded as A and B by an independent statistician, transferred to the SPSS program and analyzed., whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 58, type: ESTIMATED, armsInterventionsModule interventions name: motivational interviewing, outcomesModule primaryOutcomes measure: Motivational interviewing has an effect on nursing students' social anxiety., secondaryOutcomes measure: Motivational interviewing has an effect on nursing students' dating violence., otherOutcomes measure: Motivational interviewing has an effect on nursing students' self-compassion., eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 25 Years, stdAges: ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06272864, orgStudyIdInfo id: BEGIN study, briefTitle: BostonGene and Exigent Genomic INsight Study, acronym: BEGIN, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-08, primaryCompletionDateStruct date: 2026-01-08, completionDateStruct date: 2028-01-08, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: BostonGene, class: INDUSTRY, collaborators name: Exigent, descriptionModule briefSummary: The BEGIN Study by BostonGene and Exigent Genomic INsight evaluates the efficacy of comprehensive molecular testing in advanced cancer patients. Using the BostonGene Tumor Portrait test, the study aims to identify actionable findings, assess feasibility, and determine patient enrollment in clinical trials. Four cohorts of 100 patients each will be studied over two years, focusing on treatment decisions and patient outcomes. This study seeks to demonstrate the clinical utility of genomic testing in guiding therapy for advanced cancer patients in community settings., conditionsModule conditions: Breast Cancer, conditions: Non-small Cell Lung Cancer, conditions: Melanoma, conditions: Sarcoma, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 400, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Frequency of actionable findings, primaryOutcomes measure: Test turn-around time, secondaryOutcomes measure: Frequency of patients who receive molecularly matched therapy, secondaryOutcomes measure: Frequency of patients who receive molecularly matched therapy, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Northwest Medical Specialities, city: Puyallup, state: Washington, zip: 98373, country: United States, contacts name: Sibel Blau, MD, role: CONTACT, geoPoint lat: 47.18538, lon: -122.2929, hasResults: False
protocolSection identificationModule nctId: NCT06272851, orgStudyIdInfo id: Choroidal thickness by OCT, briefTitle: Measuring Choroidal Thickness Using Optical Coherence Tomography, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-15, primaryCompletionDateStruct date: 2029-03-30, completionDateStruct date: 2029-05-15, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: To compare the choroidal thickness in eyes of diabetic patients with eyes of age matched controls using optical coherence tomography., conditionsModule conditions: Choroid Disease, conditions: Diabetes Mellitus, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 122, type: ESTIMATED, armsInterventionsModule interventions name: optical coherence tomography, outcomesModule primaryOutcomes measure: comparison between choroidal thickness, eligibilityModule sex: ALL, minimumAge: 30 Years, maximumAge: 95 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06272838, orgStudyIdInfo id: 2023-19/145, briefTitle: Biodex Balance System in Patients With Parkinson's Disease, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-28, primaryCompletionDateStruct date: 2024-09-14, completionDateStruct date: 2024-10-14, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Kirsehir Ahi Evran Universitesi, class: OTHER, descriptionModule briefSummary: Conventional balance exercises are an effective rehabilitation method applied in routine rehabilitation programs for Parkinson's patients. With technological developments, balance exercises, conditionsModule conditions: Parkinson Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomised controlled, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: Investigator and Outcomes Assessor will be different persons, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Biodex balance system, interventions name: The conventional balance exercise program, outcomesModule primaryOutcomes measure: Berg Balance Scale, primaryOutcomes measure: Berg Balance Scale, primaryOutcomes measure: Berg Balance Scale, primaryOutcomes measure: Biodex dynamic balance score, primaryOutcomes measure: Biodex dynamic balance score, primaryOutcomes measure: Biodex dynamic balance score, primaryOutcomes measure: The fall efficacy scale, primaryOutcomes measure: The fall efficacy scale, primaryOutcomes measure: The fall efficacy scale, primaryOutcomes measure: Time up and go test, primaryOutcomes measure: Time up and go test, primaryOutcomes measure: Time up and go test, secondaryOutcomes measure: The 8-item version of the Parkinson's Disease Questionnaire (PDQ-8), secondaryOutcomes measure: The 8-item version of the Parkinson's Disease Questionnaire (PDQ-8), secondaryOutcomes measure: The 8-item version of the Parkinson's Disease Questionnaire (PDQ-8), secondaryOutcomes measure: The Five Times Sit to Stand Test, secondaryOutcomes measure: The Five Times Sit to Stand Test, secondaryOutcomes measure: The Five Times Sit to Stand Test, secondaryOutcomes measure: Beck Depression Inventory, secondaryOutcomes measure: Beck Depression Inventory, secondaryOutcomes measure: Beck Depression Inventory, eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Kırşehir Ahi Evran University Faculty of Medicine, status: RECRUITING, city: Kırşehir, state: City Center, zip: 40100, country: Turkey, contacts name: Basak Cigdem Karacay, Asist Prof, role: CONTACT, phone: 0905445094803, email: basak.cigdemkaracay@ahievran.edu.tr, contacts name: Basak Cigdem Karacay, Asist Prof, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.14583, lon: 34.16389, hasResults: False
protocolSection identificationModule nctId: NCT06272825, orgStudyIdInfo id: 2023-19/140, briefTitle: Virtual Reality in Patients With Knee Osteoarthritis, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-28, primaryCompletionDateStruct date: 2024-07-14, completionDateStruct date: 2024-08-14, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Kirsehir Ahi Evran Universitesi, class: OTHER, descriptionModule briefSummary: One of the main challenges facing the therapist in the treatment of adhesive capsulitis is to motivate the patient throughout conventional therapy. As noted in a recent review, individuals are more interested in leisure activities rather than performing repetitive tasks during therapy. Virtual reality (VR) is a three-dimensional computer-aided programme built with a system that creates virtual reality movements and generates a high amount of visual and sensory feedback during exercise. As a result, virtual reality (VR) has been used in many medical indications and has been shown to promote adherence to treatment by increasing patient motivation., conditionsModule conditions: Knee Osteoarthritis, conditions: Pain, conditions: Quality of Life, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomised controlled, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: Investigator and Outcomes Assessor will be different persons., whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Virtual reality, interventions name: conventional rehabilitation, outcomesModule primaryOutcomes measure: Visual Analog Scale, primaryOutcomes measure: Visual Analog Scale, primaryOutcomes measure: Visual Analog Scale, primaryOutcomes measure: The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), primaryOutcomes measure: The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), primaryOutcomes measure: The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), primaryOutcomes measure: Biodex Balance System, primaryOutcomes measure: Biodex Balance System, primaryOutcomes measure: Biodex Balance System, secondaryOutcomes measure: Short Form 36 (SF36), secondaryOutcomes measure: Short Form 36 (SF36), secondaryOutcomes measure: Short Form 36 (SF36), eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 85 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Kırşehir Ahi Evran University Faculty of Medicine, status: RECRUITING, city: Kırşehir, state: City Center, zip: 40100, country: Turkey, contacts name: Basak Cigdem Karacay, Asist Prof, role: CONTACT, phone: 0905445094803, email: basak.cigdemkaracay@ahievran.edu.tr, contacts name: Basak Cigdem Karacay, Asist Prof, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.14583, lon: 34.16389, hasResults: False
protocolSection identificationModule nctId: NCT06272799, orgStudyIdInfo id: RS1480/21, briefTitle: Tolerability and Efficacy of Adjuvant T-DM1 in Patients With HER2 Positive Breast Cancer After Incomplete Pathological Response to Neoadjuvant Chemotherapy Including Anti-HER2 Agents. Real-world Multicenter Retrospective-prospective Study, acronym: ATD, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-09-20, primaryCompletionDateStruct date: 2024-09-20, completionDateStruct date: 2024-09-20, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Regina Elena Cancer Institute, class: OTHER, descriptionModule briefSummary: Multicenter, retrospective-prospective, real-world observational study, with the aim of evaluating tolerability and efficacy in a population of patients treated according to clinical practice outside of studies randomized., conditionsModule conditions: Breast Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 160, type: ESTIMATED, armsInterventionsModule interventions name: T-DM1 adjuvant, outcomesModule primaryOutcomes measure: Evaluate the tolerability., secondaryOutcomes measure: Evaluate the effectiveness of treatment., eligibilityModule sex: FEMALE, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: "Regina Elena" National Cancer Institute, status: RECRUITING, city: Rome, zip: 00144, country: Italy, contacts name: Patrizia Vici, Doctor, role: CONTACT, phone: 06-5266.5584, phoneExt: +39, email: patrizia.vici@ifo.it, geoPoint lat: 41.89193, lon: 12.51133, hasResults: False