hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06371820, orgStudyIdInfo id: 2014/1287-31/4, briefTitle: ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden), acronym: ESPRESSO, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 1965-01-01, primaryCompletionDateStruct date: 2043-05-17, completionDateStruct date: 2043-05-17, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Karolinska Institutet, class: OTHER, descriptionModule briefSummary: The ESPRESSO study is a collection of data from all computerised gastrointestinal histopathology reports in Sweden. This allows us to study risk factors for gastrointestinal disease, as well as the prognosis of gastrointestinal disease.A review of the study has been published here:https://pubmed.ncbi.nlm.nih.gov/30679926/, conditionsModule conditions: Gastrointestinal Diseases, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 13000000, type: ACTUAL, armsInterventionsModule interventions name: ESPRESSO [The study has no intervention], outcomesModule primaryOutcomes measure: Incident Mortality [especially rates], secondaryOutcomes measure: Incident Cancer, secondaryOutcomes measure: Incident Cardiovascular disease, secondaryOutcomes measure: Incident Neurological disease, secondaryOutcomes measure: Incident Autoimmune diseases, otherOutcomes measure: Please note that the recorded outcomes above are examples. Other outcomes may also be studied., eligibilityModule sex: ALL, minimumAge: 0 Years, maximumAge: 110 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06371807, orgStudyIdInfo id: EU CTR n.º 2023-507008-30-00, briefTitle: Trial for Treatment of High Risk BC With Two Sequences of Neoadjuvant Chemotherapy With Pembrolizumab, acronym: KEYPARTNER, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-07, primaryCompletionDateStruct date: 2025-07, completionDateStruct date: 2026-12, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Fundacao Champalimaud, class: OTHER, descriptionModule briefSummary: Phase II, randomized, Active-controlled open label trial for treatment of high risk, HR-/HER2- (triple negative) breast cancer, with two sequences of neoadjuvant chemotherapy on a background of pembrolizumab, conditionsModule conditions: Early Breast Cancer, conditions: Triple Negative Breast Cancer, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Pembrolizumab injection, outcomesModule primaryOutcomes measure: Detect immunologic activation signal and the immunologically defined most suitable patient population for the synergistic interaction between pembrolizumab and chemotherapy backbone, primaryOutcomes measure: Rate of pCR, primaryOutcomes measure: Primary translational endpoint, secondaryOutcomes measure: Changes in the immunogenic phenotype, secondaryOutcomes measure: Incidence of treatment relatred Adverse events, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 100 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Fundaçao Champalimaud, Avenida Brasilia,, city: Lisbon, zip: 1400-038, country: Portugal, contacts name: Ines Sousa, MSc, role: CONTACT, phone: +351 210480048, email: ines.sousa@fundacaochampalimaud.pt, contacts name: Fatima Cardoso, MD, role: CONTACT, phone: +351 210480048, email: fatimacardoso@fundacaochampalimaud.pt, geoPoint lat: 38.71667, lon: -9.13333, locations facility: Centro Hospitalar Universitário Lisboa Norte E.P.E, city: Lisbon, zip: 1649-028, country: Portugal, geoPoint lat: 38.71667, lon: -9.13333, locations facility: Instituto Português de Oncologia Francisco Gentil, E.P.E, city: Oporto, zip: 4200-072, country: Portugal, contacts name: Joana Maia, role: CONTACT, phone: 22 508 40 00, phoneExt: 2040, email: joana.h.maia@ipoporto.min-saude.pt, contacts name: Miguel Abreu, MD, role: CONTACT, phone: 22 508 40 00, phoneExt: 2040, email: antonio.m.abreu@ipoporto.min-saude.pt, geoPoint lat: 41.14961, lon: -8.61099, hasResults: False
protocolSection identificationModule nctId: NCT06371755, orgStudyIdInfo id: ULTRADXA, briefTitle: Bone Evaluation by Ultrasound Radiofrequency Echographic Multi Spectrometry (REMS) vs Dual X-ray Absorptiometry (DXA), statusModule overallStatus: RECRUITING, startDateStruct date: 2019-11-19, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Paola Pisani, class: INDUSTRY, collaborators name: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio, descriptionModule briefSummary: Bone Density Evaluation by means of the Ultrasound Technology Named Radiofrequency Echographic Multi Spectrometry (REMS) in Comparison With DXA Technique.Clinical Center involved in the study:IRCCS Orthopedic institute Galeazzi - Sant'Ambrogio The clinical study will evaluate the intra- and inter-operator repeatability of the REMS,(Radiofrequency Echographic Multi Spectrometry) ultrasound diagnostic technology implemented in the EchoStation device (Echolight Spa, Lecce) and the diagnostic accuracy in comparison with DXA (used as standard reference)., conditionsModule conditions: Osteoporosis Diagnosis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 296, type: ESTIMATED, armsInterventionsModule interventions name: Ultrasound examination with REMS technology, outcomesModule primaryOutcomes measure: 1. REMS Technology intra - and inter-operator repeatability Evaluation., secondaryOutcomes measure: 1. Evaluation of the accuracy of the REMS Technology in comparison with the conventional DXA technique., eligibilityModule sex: FEMALE, minimumAge: 30 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio, status: RECRUITING, city: Milano, state: MI, zip: 20157, country: Italy, contacts name: Carmelo Messina, Professor, role: CONTACT, phone: 0039 02 8350 1406, email: carmelomessina.md@gmail.com, geoPoint lat: 45.46427, lon: 9.18951, hasResults: False
protocolSection identificationModule nctId: NCT06371742, orgStudyIdInfo id: 539HydrationNutr, briefTitle: Study of the Fluid Intake Effect During Labour, statusModule overallStatus: COMPLETED, startDateStruct date: 2017-02-01, primaryCompletionDateStruct date: 2017-07-14, completionDateStruct date: 2017-09-14, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Egas Moniz - Cooperativa de Ensino Superior, CRL, class: OTHER, descriptionModule briefSummary: Ingestion during labor is an issue that has attracted the attention of the scientific community in recent decades, with different practices occurring in different countries. However, the scientific evidence of the risk / benefit of fluid intake in labor is still not fully understood. The aim of this study was to contribute with data that allow the evaluation of an eventual relationship between the amount of fluid ingested during labor and the type of delivery, the duration of labor, the occurrence of nausea and vomiting and the value of the Index of Apgar at the 1st and 5th minutes of the newborn's life. An observational study, with a convenience sample of 144 parturient from two hospitals of Portugal were employed. The analysis was based on recording the before mentioned variables and potentially confounding variables. In order to control for potential sources of bias in the study and to guarantee the homogeneity of the sample in the specific statistical treatment of each dependent variable, an observation grid was drawn up for all the participants in the study. Twenty eight of the parturient, the parturient's ambulation, labour analgesia, food intake during labour, the use of oxytocin during labour, the occurrence of postpartum complications, the birth weight of the newborn and the occurrence of birth complications., conditionsModule conditions: Labor Complication, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 144, type: ACTUAL, armsInterventionsModule interventions name: Liquid ingestion during labour, outcomesModule primaryOutcomes measure: Type of labour, primaryOutcomes measure: Duration of labour, primaryOutcomes measure: Occurrence of nausea and vomiting, primaryOutcomes measure: Apgar index of the newborn (From 0 to 10), eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 39 Years, stdAges: ADULT, contactsLocationsModule locations facility: Egas Moniz School of Health and Science, city: Almada, state: Monte De Caparica, zip: 2829-699, country: Portugal, geoPoint lat: 38.67902, lon: -9.1569, hasResults: False
protocolSection identificationModule nctId: NCT06371729, orgStudyIdInfo id: DEEP-VT, briefTitle: Substrate-based DEEP Mapping Versus Activation Mapping. A Prospective Randomized Multicenter Study., statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-07, primaryCompletionDateStruct date: 2027-07, completionDateStruct date: 2027-07, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-18, sponsorCollaboratorsModule leadSponsor name: IRCCS Ospedale San Raffaele, class: OTHER, descriptionModule briefSummary: Substrate-based DEEP mapping and activation mapping are the two main techniques used for ventricular tachycardia (VT) ablation. There is no sufficiently reliable data in the medical scientific literature comparing the extent of applicability, the results of the procedure strategy, and the long-term outcomes between the two mapping strategies. This randomized clinical trial aims to test whether activation mapping is superior to DEEP mapping to reduce ventricular tachycardia recurrence.The primary outcome of the study is to compare the efficacy as a recurrence-free survival rate of ventricular tachycardia, at 6 and 12 months, of substrate-based DEEP mapping versus activation mapping in guiding catheter ablation to prevent VT recurrence., conditionsModule conditions: Ventricular Tachycardia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 222, type: ESTIMATED, armsInterventionsModule interventions name: DEEP mapping, interventions name: Activation Mapping, outcomesModule primaryOutcomes measure: Compare the efficacy of substrate-based DEEP mapping versus Activation mapping in guiding catheter ablation to prevent VT recurrences, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06371716, orgStudyIdInfo id: EUS-RFA ex-vivo 2016, briefTitle: Ex-vivo Ultrasound Guided Radiofrequency Ablation on Pancreatic Solid Lesions, statusModule overallStatus: TERMINATED, startDateStruct date: 2019-09-12, primaryCompletionDateStruct date: 2020-06-12, completionDateStruct date: 2020-06-12, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: IRCCS San Raffaele, class: OTHER, descriptionModule briefSummary: The study investigates the feasibility and the efficacy to treat pancreatic solid lesions as pancreatic adenocarcinomas (PDAC) and neuroendocrine tumors (NET) with ex-vivo radiofrequency ablation (RFA) under ultrasound (US) control.The study intent is to define the optimal radiofrequency ablation POWER of the system in terms of maximum sizes (diameters) of histological coagulative necrosis obtained at pathological samples. Results will be useful to define the optimal settings to ablate pancreatic solid lesions (PDAC and neuroendocrine tumours)., conditionsModule conditions: Pancreatic Cancer, conditions: Endoscopic Ultrasound, conditions: Radiofrequency Ablation, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: 15 resected PDAC without neoadjuvant treatment 15 resected PDAC with neoadjuvant treatment 15 resected neuroendocrine tumorsEach group (15 patients each) Subgroup A: 10 W (5 patients) Subgroup B: 30 W (5 patients) Subgroup C: 50 W (5 patients), primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: pathologists (two different pathologist blinded about the power of RFA applied and respect to the other pathologist) will evaluate the effect of ablation (coagulative necrosis at microscopic evaluation), whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 45, type: ACTUAL, armsInterventionsModule interventions name: ex-vivo RFA under US control at 10 Watts (W) of power in 3 differents arms of lesions, interventions name: ex-vivo RFA under US control at 30 Watts (W) of power in 3 differents arms of lesions, interventions name: ex-vivo RFA under US control at 50 Watts (W) of power in 3 differents arms of lesions, outcomesModule primaryOutcomes measure: diameter (millimeters) of coagulative necrosis obtained by RadioFrequency Ablation, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: IRCCS San Raffaele Hospital, city: Milan, country: Italy, geoPoint lat: 45.46427, lon: 9.18951, hasResults: False
protocolSection identificationModule nctId: NCT06371703, orgStudyIdInfo id: PETCT_INTEGO, briefTitle: Enhancing Radiation Safety for Nuclear Medicine Radiographers: the Impact of Introducing the Automat-ed Radiopharmaceutical Preparation and Administration System, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-07, primaryCompletionDateStruct date: 2024-10, completionDateStruct date: 2024-10, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: IRCCS San Raffaele, class: OTHER, descriptionModule briefSummary: This project aims to evaluate the impact of the introduction of an automated system for radiopharmaceutical preparation and administration on the radiation safety of the radiographers working in nuclear medicine. This study will help to fill the existing gap in the scientific literature and provide useful guidance for the selection of the safest and most effective automated infusion system., conditionsModule conditions: Radiation Exposure, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CROSSOVER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: automated system in reducing radiation exposure, outcomesModule primaryOutcomes measure: Change in absorbed dose by radiographers during PET/CT procedures, measured in millisieverts (mSv)., eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Irccs San Raffaele, city: Milano, country: Italy, geoPoint lat: 45.46427, lon: 9.18951, hasResults: False
protocolSection identificationModule nctId: NCT06371690, orgStudyIdInfo id: 17-11/37, briefTitle: The Effects of Using the Web-Based Double Eye Control Program on Medication Error, statusModule overallStatus: COMPLETED, startDateStruct date: 2017-11-01, primaryCompletionDateStruct date: 2018-06-30, completionDateStruct date: 2018-09-30, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Izmir Katip Celebi University, class: OTHER, collaborators name: Ege University, descriptionModule briefSummary: Methods: The study was carried out as a quasi-experimental study in the Pediatric Surgery Clinics of a university hospital using the "Pre-Test-Post-Test Model in a Single Group". The sample of the study consisted of all high-risk drugs administered by 24 nurses working in these clinics, taking part in medication and agreeing to take part in the study. Data were collected by the researcher using the Medication Observation Form. The Form was created based on the literature, and by making use of the "10 Correct Rules in Medication" and the Medication Skills Steps in the Double Eye Control Program. In the first step, medication error rates were determined through observation method. In the second step; the Web-Based Double-Eye Control Program, which is a standard drug dose calculation and medication program created by the researchers, was started to be implemented. Medication error rates were determined again through post-intervention observation method. Informed voluntary consent, ethics committee and hospital permissions were obtained for the implementation of the study., conditionsModule conditions: Main Heading (Descriptor) Terms, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CROSSOVER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 1070, type: ACTUAL, armsInterventionsModule interventions name: Web-Based Double-Eye Control Program, outcomesModule primaryOutcomes measure: Error rates, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Izmir Katip Celebi University, city: İzmir, state: Çi̇ğli̇, zip: 35620, country: Turkey, geoPoint lat: 38.41273, lon: 27.13838, hasResults: False
protocolSection identificationModule nctId: NCT06371677, orgStudyIdInfo id: KB/2024, briefTitle: Polish Nationwide Register of Hospitalized Patients in Cardiac Intensive Care Units, acronym: POL-CICU, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-10-01, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2025-03-31, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Medical University of Warsaw, class: OTHER, descriptionModule briefSummary: Cardiac Intensive Care Units (CICUs) provide care for a diverse patient population. Understanding the clinical characteristics, analysis of treatment modalities, and prognosis of patients hospitalized in the CICU are important to improve cardiovascular care. The purpose of this registry is to determine the demographics, clinical, treatment, and prognosis of patients hospitalized in the Polish CICUs. Data from this multicenter, prospective observational study will provide more robust data to facilitate quantitative characterization of cardiac care in contemporary Polish CICUs and enable the development of infrastructure for clinical trials in CICUs., conditionsModule conditions: Shock, conditions: Death, conditions: Cardiac Intensive Care Unit, conditions: Treatment Complication, conditions: Stroke, conditions: Multiple Organ Failure, conditions: Infections, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 2000, type: ESTIMATED, outcomesModule primaryOutcomes measure: All-cause death, secondaryOutcomes measure: Shock (cardiogenic/hypovolemic/anaphylactic/septic/neurogenic/obstructive), secondaryOutcomes measure: Treatment-related complications (tamponade, dissection, stroke, embolism, etc.), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06371664, orgStudyIdInfo id: 2023/02, briefTitle: Gingival Irritation Due to Bleaching Tray Design in an At-home Bleaching Treatment, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-03-01, primaryCompletionDateStruct date: 2023-04-05, completionDateStruct date: 2023-04-05, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: University of Santiago de Compostela, class: OTHER, descriptionModule briefSummary: The primary aim of this study is to assess whether the design of the bleaching tray used in at-home bleaching treatment is directly correlated with the risk of gingival irritation. Additionally, it aims to investigate whether the design influences the likelihood of dental sensitivity and its impact on the degree of tooth whitening., conditionsModule conditions: Gingival Inflammation, designModule studyType: INTERVENTIONAL, phases: EARLY_PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized, triple-blind clinical trial, primaryPurpose: PREVENTION, maskingInfo masking: TRIPLE, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 72, type: ACTUAL, armsInterventionsModule interventions name: Conventional Tray (1 mm), interventions name: Extended Tray (3 mm), outcomesModule primaryOutcomes measure: Subjective questionnaire of gingival irritation, primaryOutcomes measure: Objective clinical examination of gingival irritation, secondaryOutcomes measure: Questionnaire of dental sensitivity, secondaryOutcomes measure: Shade evaluation with a dental spectrophotometer, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: School of Medicine and Dentistry, city: Santiago De Compostela, state: A Coruña, zip: 15705, country: Spain, geoPoint lat: 42.88052, lon: -8.54569, hasResults: False
protocolSection identificationModule nctId: NCT06371651, orgStudyIdInfo id: 23-1462-3, briefTitle: Creatine and GAA for Brain Oxygenation, acronym: CREGAA-OXY, statusModule overallStatus: COMPLETED, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2024-04-10, completionDateStruct date: 2024-04-12, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: University of Novi Sad, Faculty of Sport and Physical Education, class: OTHER, descriptionModule briefSummary: The main aim of this randomized controlled trial is to evaluate cerebral blood oxygenation after 7-day administration of a creatine-guanidinoacetic acid (GAA) mixture in healthy adults before, during, and after a series of cognitive tests., conditionsModule conditions: Oxygen Deficiency, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 19, type: ACTUAL, armsInterventionsModule interventions name: Supplement, interventions name: Placebo, outcomesModule primaryOutcomes measure: Brain oxygen saturation, secondaryOutcomes measure: Hemoglobin index, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 30 Years, stdAges: ADULT, contactsLocationsModule locations facility: Applied Bioenergetics Lab at Faculty of Sport and PE, city: Novi Sad, state: Vojvodina, zip: 21000, country: Serbia, geoPoint lat: 45.25167, lon: 19.83694, hasResults: False