protocolSection identificationModule nctId: NCT06381245, orgStudyIdInfo id: KB/265/2023, briefTitle: First-time Ablation of Atrial Fibrillation Registry, acronym: DIPE, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-01, primaryCompletionDateStruct date: 2026-03-31, completionDateStruct date: 2026-03-31, studyFirstPostDateStruct date: 2024-04-24, lastUpdatePostDateStruct date: 2024-04-24, sponsorCollaboratorsModule leadSponsor name: Medical University of Warsaw, class: OTHER, descriptionModule briefSummary: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia affecting millions globally, with projections indicating a doubling of cases by 2050. AF is linked to heightened cardiovascular risks like stroke and increased healthcare costs. Ablation, targeting the arrhythmia substrate, is a method to manage AF, yet recurrence rates remain high (20-45% in the first year). Studies highlight the impact of comorbidities, AF characteristics, ablation techniques, and myocardial remodeling markers on AF progression and ablation efficacy. However, there's no definitive guidance on selecting these factors for predicting treatment success.The aim of this study is to investigate predictors of successful AF ablation in the following areas: (a) clinical factors, (b) electrophysiological, (c) electrocardiographic, (d) ultrasound, (e) cardiac anatomy, (f) biomarkers., conditionsModule conditions: Atrial Fibrillation, conditions: Arrhythmia, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 400, type: ESTIMATED, armsInterventionsModule interventions name: PPG-based remote heart rhythm/rate monitoring, interventions name: ECG-based remote heart rhythm/rate monitoring, interventions name: Transthoracic and transesophageal echocardiography examination, interventions name: Liver ultrasound examination, interventions name: Rotational angiography with three-dimensional reconstruction, interventions name: Blood-derived biomarker analysis, interventions name: Mobile health-based spirometry, outcomesModule primaryOutcomes measure: Late AF recurrence, secondaryOutcomes measure: Late recurrence of AF or atrial tachycardia or atrial flutter, secondaryOutcomes measure: Early recurrence of AF, secondaryOutcomes measure: Early recurrence of AF or atrial tachycardia or atrial flutter, secondaryOutcomes measure: Time to AF recurrence and the impact of early recurrence on late AF recurrence, secondaryOutcomes measure: The superiority of monitoring using mobile health devices over traditional heart rhythm monitoring, secondaryOutcomes measure: Progression or regression of AF, secondaryOutcomes measure: Modification of treatment, including antiarrhythmic treatment, secondaryOutcomes measure: AF-related quality of life and symptoms, secondaryOutcomes measure: Periprocedural complications, secondaryOutcomes measure: Heart rate variability and rate, secondaryOutcomes measure: Blood biomarker levels, secondaryOutcomes measure: Ablation procedure parameters, secondaryOutcomes measure: Cardiac remodelling, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Medical University of Warsaw, status: RECRUITING, city: Warsaw, country: Poland, contacts name: Monika Gawałko, MD, PhD, role: CONTACT, phone: 22 599 19 58, phoneExt: +48, email: monika.gawalko@wum.edu.pl, contacts name: Monika Gawałko, MD, PhD, role: PRINCIPAL_INVESTIGATOR, contacts name: Paweł Balsam, MD, PhD, role: PRINCIPAL_INVESTIGATOR, contacts name: Piotr Lodziński, MD, PhD, role: SUB_INVESTIGATOR, contacts name: Michał Marchel, MD, PhD, role: SUB_INVESTIGATOR, contacts name: Michał Peller, MD, PhD, role: SUB_INVESTIGATOR, contacts name: Bartosz Krzowski, MD, PhD, role: SUB_INVESTIGATOR, contacts name: Cezary Maciejewski, MD, PhD, role: SUB_INVESTIGATOR, contacts name: Maria Boszko, MD, role: SUB_INVESTIGATOR, contacts name: Michał Gawlik, MD, role: SUB_INVESTIGATOR, contacts name: Karolina Mitrzak, MD, role: SUB_INVESTIGATOR, contacts name: Alicja Skrobucha, MD, role: SUB_INVESTIGATOR, contacts name: Mateusz Wawrzeńczyk, MD, role: SUB_INVESTIGATOR, geoPoint lat: 52.22977, lon: 21.01178, hasResults: False