hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06275230, orgStudyIdInfo id: ZRJY2021-BJ08-02-07, briefTitle: Establishment of Human Lung Stem Cell Proliferation System and Organoid Construction in COPD, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-20, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-02-23, sponsorCollaboratorsModule leadSponsor name: China-Japan Friendship Hospital, class: OTHER, descriptionModule briefSummary: The goal of this study is to proliferate human lung stem cell in vitro in order to establish a lung organoid derived from patients with COPD. The main question it aims to answer are:* Can human lung stem cell proliferate in vitro.* Can a lung organoid derived from patients with COPD be established. Participants will be sampled during pulmonary bronchoscope for organoid establishment., conditionsModule conditions: Chronic Obstructive Pulmonary Disease, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Number of Patients completed bronchoscope., eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06275217, orgStudyIdInfo id: HMRF17182481, briefTitle: Mindful Yoga for Postpartum Depression, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-01-08, primaryCompletionDateStruct date: 2025-07-15, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-02-23, sponsorCollaboratorsModule leadSponsor name: The Hong Kong Polytechnic University, class: OTHER, descriptionModule briefSummary: This is a parallel-group randomized controlled trial. A total of 198 postpartum women with depressive symptoms (EPDS scores≥8 at baseline) will be recruited and randomized into two groups: 10-week mindful yoga intervention and 10-week psychoeducation program. Clinical assessment of depression, self-report questionnaires and salivary cortisol tests will be performed at baseline, after 10-week intervention, and at 6-month and 12-month follow-ups. The investigators expected that the mindful yoga intervention will reduce depression after 10 weeks compared to psychoeducation. The mindful yoga intervention will further reduce anxiety, stress, improve quality of life and sleep, and steepen diurnal cortisol slopes. These effects will be maintained for at least six months., conditionsModule conditions: Mood Disorders, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 198, type: ESTIMATED, armsInterventionsModule interventions name: Mindfulness-based yoga program, interventions name: Psychoeducation, outcomesModule primaryOutcomes measure: Edinburgh Postnatal Depression Scale, secondaryOutcomes measure: Depression Anxiety Stress Scale-Depression, secondaryOutcomes measure: Depression Anxiety Stress Scale-Anxiety, secondaryOutcomes measure: Depression Anxiety Stress Scale-Stress, secondaryOutcomes measure: Pittsburgh Sleep Quality Index, secondaryOutcomes measure: 36 Item-Short Form Health Survey Questionnaire, secondaryOutcomes measure: Five Facet Mindfulness Questionnaire, secondaryOutcomes measure: Pregnancy Symptom Inventory, secondaryOutcomes measure: Cortisol concentration level, secondaryOutcomes measure: Physical fitness, secondaryOutcomes measure: Balance, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: The Hong Kong Polytechnic University, status: RECRUITING, city: Hong Kong, country: Hong Kong, contacts name: Jessie JX Lin, PhD, role: CONTACT, email: jx-jessie.lin@polyu.edu.hk, geoPoint lat: 22.27832, lon: 114.17469, hasResults: False
protocolSection identificationModule nctId: NCT06275178, orgStudyIdInfo id: ZRJY2021-BJ08-02-04, briefTitle: Medical Thoracoscopy for Diagnosing Unexplained Pleural Effusion: a National Multicenter Retrospective Study, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-20, primaryCompletionDateStruct date: 2024-12-24, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-02-23, sponsorCollaboratorsModule leadSponsor name: China-Japan Friendship Hospital, class: OTHER, descriptionModule briefSummary: This study is a national multicenter retrospective study. Patients with unexplained pleural effusion who underwent thoracoscopic or video-assisted thoracoscopic biopsy for patients in recent 10 years were retrospectively collected from multiple centers to understand the proportion and final etiological composition of pleural effusion in China., conditionsModule conditions: Pleural Effusion, conditions: Pleural Effusion, Malignant, conditions: Fibrinous Pleuritis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: RETROSPECTIVE, enrollmentInfo count: 5000, type: ESTIMATED, armsInterventionsModule interventions name: Medical thoracoscopy, outcomesModule primaryOutcomes measure: The proportion of fibrinous pleurisy in Chinese population, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06275165, orgStudyIdInfo id: 202301754B0, briefTitle: The Effects of Acupressure on Improving Postoperative Gastrointestinal Symptom Distress in Esophageal Cancer Patients, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-27, primaryCompletionDateStruct date: 2025-07-18, completionDateStruct date: 2025-07-18, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-03-29, sponsorCollaboratorsModule leadSponsor name: CHEN, CHIA-CHEN, class: OTHER, descriptionModule briefSummary: This study is a quasi-experimental design clinical trial with the primary objective of comparing the health status of patients with esophageal cancer. Participants were divided into an experimental group and a control group. Patients in the experimental group received routine care and acupressure for 5 consecutive days starting from the day after entering the ward after esophageal cancer surgery, in the control group, participants received routine care, and Participants were assessed on the Gastrointestinal Symptom Distress Scale at the end of the intervention. The aim of this study was to verify the effectiveness of acupressure in improving of gastrointestinal symptoms distress after esophageal cancer surgery., conditionsModule conditions: Esophageal Cancer, conditions: Gastrointestinal Dysfunction, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Participants were divided into an experimental group and a control group. experimental group: received acupressure for 5 days in addition to regular care.control group: received regular postoperative care., primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: acupressure, outcomesModule primaryOutcomes measure: Change from Baseline in gastrointestinal symptom distress Scale at study day 5(end day), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 85 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Chang Gung Memotial Hospital, status: RECRUITING, city: Taoyuan, country: Taiwan, contacts name: Chia-Chen Chen, role: CONTACT, phone: +886-3-3281200, phoneExt: 3005, email: mymychen73@gmail.com, geoPoint lat: 24.95233, lon: 121.20193, hasResults: False
protocolSection identificationModule nctId: NCT06275152, orgStudyIdInfo id: HDRIC-01, briefTitle: The Protective Effect of Remote Ischemic Conditioning on Residual Renal Function in Hemodialysis Patients (RIC-HD), acronym: RIC-HD, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2024-02-20, primaryCompletionDateStruct date: 2026-01-19, completionDateStruct date: 2026-01-19, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-02-26, sponsorCollaboratorsModule leadSponsor name: Yuanjun Yang, class: OTHER, descriptionModule briefSummary: Hemodialysis (HD) is the main renal replacement therapy for patients with end-stage renal disease. However, factors such as hemodynamic instability can lead to gradual loss of residual renal function (RRF) in HD patients. The loss of RRF not only affects the adequacy of dialysis and complications control but also impacts the patients' quality of life and survival. Unfortunately, there are currently no effective methods to protect RRF. The purpose of this study is to validate the protective effect of remote ischemic conditioning (RIC) on RRF in HD patients. This will provide evidence for the application of RIC in protecting RRF in HD patients., conditionsModule conditions: End-stage Renal Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: randomized controlled pilot study, primaryPurpose: PREVENTION, maskingInfo masking: QUADRUPLE, maskingDescription: Only Research Assistant will be unblinded. Participant, clinical team, PI, etc. will all be blinded to the randomization group., whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Remote ischemic conditioning, interventions name: Sham Remote Ischemic Conditioning, outcomesModule primaryOutcomes measure: time to anuria, primaryOutcomes measure: residual renal function (RRF), primaryOutcomes measure: Change in the renal cerebral oxygen saturation, secondaryOutcomes measure: serum creatinine, secondaryOutcomes measure: serum urea nitrogen, secondaryOutcomes measure: C-reactive protein (CRP), secondaryOutcomes measure: Interleukin-6, secondaryOutcomes measure: TFF3, secondaryOutcomes measure: KIM-1, secondaryOutcomes measure: IP-10, otherOutcomes measure: hemoglobin, otherOutcomes measure: systolic pressure, otherOutcomes measure: diastolic pressure, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Chinese PLA General Hospital, city: Beijing, state: Beijing, zip: 100853, country: China, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False
protocolSection identificationModule nctId: NCT06275100, orgStudyIdInfo id: HUTH, briefTitle: PREhabilitation in Patients Awaiting Acute Inpatient Cardiac SurgEry, acronym: (PREP-ACE), statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-03, primaryCompletionDateStruct date: 2024-12, completionDateStruct date: 2025-06, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: University of Hull, class: OTHER, descriptionModule briefSummary: This is a single centre, single arm pilot feasibility study to determine the feasibility and practicality of prehabilitation in acute inpatients waiting for cardiac surgery. We will be looking into participant eligibility, acceptability, recruitment rates, completion rates and barriers to implementing a prehabilitation programme. Secondary outcomes include safety (incidence of adverse events directly related to the study), improvement in 6 minutes walk test (6MWT), hand grip strength, quality of life, and spirometry. At the end of the trial, we will be seeking the feedback of the participants to help us improve the design further., conditionsModule conditions: Cardiac Disease, conditions: Aortic Valve Disease, conditions: Coronary Artery Disease, conditions: Endocarditis, conditions: Valve Heart Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Single arm pilot feasibility study in acute inpatients waiting for cardiac surgery. Intervention is a prehabilitation program, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Prehabilitation, outcomesModule primaryOutcomes measure: Feasibility of prehabilitation in acute inpatients waiting for cardiac surgery, secondaryOutcomes measure: Efficacy of prehabilitation, secondaryOutcomes measure: Efficacy of prehabilitation, secondaryOutcomes measure: Efficacy of prehabilitation, secondaryOutcomes measure: Efficacy of prehabilitation, secondaryOutcomes measure: Efficacy of prehabilitation, secondaryOutcomes measure: Complication rate, secondaryOutcomes measure: Safety of Prehabilitation in acute inpatients waiting for surgery, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hull University Teaching Hospital, status: RECRUITING, city: Hull, zip: HU1 3DR, country: United Kingdom, geoPoint lat: 53.7446, lon: -0.33525, documentSection largeDocumentModule largeDocs typeAbbrev: Prot, hasProtocol: True, hasSap: False, hasIcf: False, label: Study Protocol, date: 2023-11-06, uploadDate: 2024-02-15T17:59, filename: Prot_000.pdf, size: 146015, largeDocs typeAbbrev: ICF, hasProtocol: False, hasSap: False, hasIcf: True, label: Informed Consent Form, date: 2023-11-06, uploadDate: 2024-02-15T18:01, filename: ICF_001.pdf, size: 107547, hasResults: False
protocolSection identificationModule nctId: NCT06275087, orgStudyIdInfo id: situm1phd, briefTitle: Differences in Speed of Recovery From Anesthesia for Intraoral Surgery, acronym: PSIOS, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-10, primaryCompletionDateStruct date: 2026-03, completionDateStruct date: 2026-07, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: Clinical Hospital Centre Zagreb, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to compare two groups of patients going in general anesthesia for intraoral surgery, the first group TIVA with propofol and the second group inhalational with sevoflurane. The main questions it aims to answer are to asses speed and quality of recovery from general anesthesia.Participants will fill out a questionnaire to evaluate the quality of recovery from anesthesia using the QoR-40 1h, 24h, and 30 days after waking up from anesthesia in comparison to the results of the same questionnaire before surgery. Also, the investigators will perform a hand grip and bite strength test on the patients after waking up from anesthesia in the operating room, after 1 hour in the recovery room, and after 24 hours compared to preoperative values.The investigators will compare TIVA and Volatile groups to see if there are any differences in recovery seed, muscle strength recovery, postoperative nausea and vomiting, and shivering between groups., conditionsModule conditions: Intraoral Tumor, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 42, type: ESTIMATED, armsInterventionsModule interventions name: Propofol, interventions name: Sevoflurane, outcomesModule primaryOutcomes measure: "Quality of recovery from anesthesia" QoR-40 questionnaire, secondaryOutcomes measure: bite strength and hand grip strength, secondaryOutcomes measure: Postoperative nausea and vomiting, secondaryOutcomes measure: Postoperative shivering, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University Hospital Centre Zagreb, status: RECRUITING, city: Zagreb, zip: 10000, country: Croatia, contacts name: Ivan Šitum, role: CONTACT, phone: 0915143620, email: ivsitum@gmail.com, contacts name: Ivan Šitum, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.81444, lon: 15.97798, hasResults: False
protocolSection identificationModule nctId: NCT06275074, orgStudyIdInfo id: 23-007716, briefTitle: Dry Needling and Therapeutic Exercise on Sleep in Individuals With Chronic Neck Pain and Sleep Disturbance, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-14, primaryCompletionDateStruct date: 2024-09-01, completionDateStruct date: 2025-03-01, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-04-05, sponsorCollaboratorsModule leadSponsor name: Mayo Clinic, class: OTHER, descriptionModule briefSummary: Feasibility study investigating the effects of dry needling on individuals with chronic neck pain and sleep disturbance., conditionsModule conditions: Neck Pain, conditions: Sleep Disturbance, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: SINGLE, maskingDescription: Outcome assessors will be blinded to group assignment of participants., whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 28, type: ESTIMATED, armsInterventionsModule interventions name: Dry Needling, interventions name: Therapeutic Exercise, outcomesModule primaryOutcomes measure: Participant retention rate, primaryOutcomes measure: Participant intervention adherence, primaryOutcomes measure: Number of adverse responses to treatment, secondaryOutcomes measure: Sleep Duration, secondaryOutcomes measure: Sleep Quality, otherOutcomes measure: Disability Level, otherOutcomes measure: Pain Level, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Mayo Clinic - Motion Analysis Lab, status: RECRUITING, city: Rochester, state: Minnesota, zip: 55905, country: United States, contacts name: Ray Lunasin, role: CONTACT, phone: 507-538-0839, email: lunasin.ray@mayo.edu, geoPoint lat: 44.02163, lon: -92.4699, hasResults: False
protocolSection identificationModule nctId: NCT06275048, orgStudyIdInfo id: STUDY00006302, briefTitle: The Influence of Oral Contraceptives During Disuse, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-26, primaryCompletionDateStruct date: 2024-12, completionDateStruct date: 2025-05, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-02-23, sponsorCollaboratorsModule leadSponsor name: University of Central Florida, class: OTHER, descriptionModule briefSummary: Studies across various sports and physical activities have consistently shown that females incur more injuries compared to their male counterparts, but the underlying reasons for this disparity remain poorly understood. While differences in hormone levels between males and females have been speculated to play a role, very little rigorous research has been conducted to directly examine potential connections between sex hormones and injury risk. Specifically, females have been shown to be at greater risk for hand and wrist injuries. The higher injury incidence begins at puberty and persists across the lifespan, suggesting a link to hormonal factors. However, significant gaps remain in understanding the relationships between the menstrual cycle, exogenous hormones from birth control, and risk factors for sports-related injury in females. The purpose of this study is to examine changes in muscle strength and neuromuscular activation among females using monophasic oral contraceptives, females not using oral contraceptives, and males during one week of wrist/hand immobilization., conditionsModule conditions: Oral Contraceptives, conditions: Rehabilitation, conditions: Menstrual Cycle, conditions: Physical Therapy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Wrist/hand immobilization, outcomesModule primaryOutcomes measure: Grip Strength, secondaryOutcomes measure: Muscle activation, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 35 Years, stdAges: ADULT, contactsLocationsModule locations facility: University of Central Florida, status: RECRUITING, city: Orlando, state: Florida, zip: 32816, country: United States, contacts name: Matt S Stock, Ph.D., role: CONTACT, phone: 407-823-0364, email: matt.stock@ucf.edu, contacts name: Matt S Stock, Ph.D., role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 28.53834, lon: -81.37924, hasResults: False
protocolSection identificationModule nctId: NCT06275035, orgStudyIdInfo id: 4235, briefTitle: Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI, acronym: MEMENTO, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-22, primaryCompletionDateStruct date: 2026-01, completionDateStruct date: 2031-01, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-03-01, sponsorCollaboratorsModule leadSponsor name: Tata Memorial Centre, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to evaluate the role of memantine in preservation of memory and neurocognition in patients undergoing craniospinal irradiation. Participants will be randomised into two arms and the interventional arm will receive memantine along with the standard treatment. Researchers will compare the neurocognitive tests of participants in both the arms to see if memantine leads to significant preservation of memory and cognition post radiation therapy., conditionsModule conditions: Neurocognitive Dysfunction, designModule studyType: INTERVENTIONAL, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 101, type: ESTIMATED, armsInterventionsModule interventions name: Memantine Oral Tablet, outcomesModule primaryOutcomes measure: Cognitive-deterioration-free survival at 2 years, secondaryOutcomes measure: Full-Scale Intelligence Quotient (FSIQ) in children, secondaryOutcomes measure: Overall survival (OS), secondaryOutcomes measure: Academic performance by scholastic performance and grades, secondaryOutcomes measure: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability] of Memantine, secondaryOutcomes measure: Progression-Free Survival (PFS), secondaryOutcomes measure: Full-Scale Intelligence Quotient (FSIQ) in adults, otherOutcomes measure: Full Scale Intelligence Quotient change in subgroups, otherOutcomes measure: Radiological features of cognitive decline on Magnetic Resonance Imaging, otherOutcomes measure: Neuroinflammatory markers correlation with neurocognitive decline and survival, eligibilityModule sex: ALL, minimumAge: 5 Years, maximumAge: 39 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Tata Memorial Hospital, status: RECRUITING, city: Mumbai, state: Maharashtra, zip: 400012, country: India, contacts name: Dr Tejpal Gupta, MD, role: CONTACT, phone: 022-24177000, phoneExt: 6015, email: tejpalgupta@rediffmail.com, geoPoint lat: 19.07283, lon: 72.88261, hasResults: False