hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06324552, orgStudyIdInfo id: RC 16/18, briefTitle: Defects of Keratinocytes Function in Dermatologic Patients, statusModule overallStatus: RECRUITING, startDateStruct date: 2020-10-12, primaryCompletionDateStruct date: 2023-06-03, completionDateStruct date: 2024-05-31, studyFirstPostDateStruct date: 2024-03-22, lastUpdatePostDateStruct date: 2024-03-22, sponsorCollaboratorsModule leadSponsor name: IRCCS Burlo Garofolo, class: OTHER, descriptionModule briefSummary: NOTCH signaling in the skin exerts a pivotal role in the regulation of normal keratinocytes turnover by mediating the balance between proliferation, differentiation, apoptosis and autophagic flux progression. Two skin diseases are characterized by the presence of gene variants that cause an impairment in NOTCH signaling: hidradenitis suppurativa(HS) and Dowling-Degos disease(DDD). To date, both HS and DDD are orphan diseases still lacking of specific treatments. This project aims at improving the current knowledge on the pathogenesis of HS and DDD, by deepening the understandings on the role played by keratinocytes in these pathologies and also by determining why mutations found in the same pathway cause different diseases. This study aimed to obtain in vitro models, derived directly from patients (from hair follicles) and from keratinocytes (HaCaT) cell cultures, for the study of these skin pathologies and also for the testing of novel innovative therapies such as photobiomodulation therapy., conditionsModule conditions: Hidradenitis Suppurativa, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 50, type: ESTIMATED, outcomesModule primaryOutcomes measure: Evaluation of the impact of candidate variants in hair follicles epithelial cell biology by generating Knock-Out (KO) keratinocyte cell lines (HaCaT), secondaryOutcomes measure: Evaluation of the impact of photobiomodulation (PBM) therapy in hair follicles epithelial cells derived from patients and in HaCaT KO cells,, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", status: RECRUITING, city: Trieste, zip: 34137, country: Italy, contacts name: Paola Maura Tricarico, BSc, role: CONTACT, phone: +39 0403785111, email: paolamaura.tricarico@burlo.trieste.it, geoPoint lat: 45.64953, lon: 13.77679, hasResults: False
protocolSection identificationModule nctId: NCT06324526, orgStudyIdInfo id: 070324QL, briefTitle: Obesity and Health-related Quality of Life in Patients Receiving Bariatric Surgery in the UK, statusModule overallStatus: COMPLETED, startDateStruct date: 2017-06-01, primaryCompletionDateStruct date: 2022-11-23, completionDateStruct date: 2022-11-23, studyFirstPostDateStruct date: 2024-03-22, lastUpdatePostDateStruct date: 2024-03-25, sponsorCollaboratorsModule leadSponsor name: Imperial College London, class: OTHER, collaborators name: University of Oxford, descriptionModule briefSummary: United Kingdom National Bariatric Surgery Registry (NBSR) records between 1st June 2017 and 23rd November 2022 were used to identify people undergoing primary bariatric (weight-loss) surgery. People undergoing primary bariatric (weight-loss) surgery with one baseline and at least one follow-up visit within one year from surgery were included. Statistical models were used to estimate the relationship between quality of life as assessed by a questionnaire and body mass index at baseline and over time., conditionsModule conditions: Quality of Life, conditions: Obesity, Morbid, conditions: Bariatric Surgery Candidate, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 2160, type: ACTUAL, armsInterventionsModule, outcomesModule primaryOutcomes measure: EQ-5D (EuroQol Five Dimension), primaryOutcomes measure: BMI, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Department of Surgery and Cancer, Imperial College London, city: London, zip: W2 1NY, country: United Kingdom, geoPoint lat: 51.50853, lon: -0.12574, hasResults: False
protocolSection identificationModule nctId: NCT06324487, orgStudyIdInfo id: E-10840098-772.02-7487, briefTitle: A New Application in Subacromial Impingement Syndrome, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2023-09-01, primaryCompletionDateStruct date: 2024-04-01, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-03-22, lastUpdatePostDateStruct date: 2024-03-22, sponsorCollaboratorsModule leadSponsor name: Medipol University, class: OTHER, descriptionModule briefSummary: Individuals diagnosed with Subacromial Impingement Syndrome by a physical therapist based on MRI results and examination findings will be included in the study. 40 people will be randomly divided into blood flow restrictive exercise (BFRT) and structured exercise program (SEP) groups, 20 people in each group. Participants will receive two evaluations: before starting treatment and immediately after 4 weeks of treatment. Pain, shoulder ROM, shoulder functional level, quality of life, shoulder muscle strength, grip strength, and sleep quality evaluation will be performed. The treatment program will be 5 days a week for a total of 4 weeks. The treatment will be individualized by calculating the appropriate resistance loads for the exercise program. All participants will undergo progressive exercises in sessions conducted by a physiotherapist., conditionsModule conditions: Subacromial Impingement Syndrome, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Progressive Exercises, interventions name: Blood Flow Restriction Therapy, outcomesModule primaryOutcomes measure: Pain İntensity, primaryOutcomes measure: Shoulder ROM, secondaryOutcomes measure: Quality of Life Assessment, secondaryOutcomes measure: Sleep Quality Assessment, secondaryOutcomes measure: Shoulder Functional Level Assessment, secondaryOutcomes measure: Shoulder Muscle Strength Assessment, secondaryOutcomes measure: Grip Strength Assessment, eligibilityModule sex: ALL, minimumAge: 25 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Medipol University, city: Istanbul, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06324474, orgStudyIdInfo id: HA treatment of periodontitis, briefTitle: Clinical and Immunological Evaluation of HA in Treatment of Periodontitis, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2024-12-12, completionDateStruct date: 2024-12-12, studyFirstPostDateStruct date: 2024-03-22, lastUpdatePostDateStruct date: 2024-03-22, sponsorCollaboratorsModule leadSponsor name: Sana'a University, class: OTHER, descriptionModule briefSummary: To evaluate the immunological effectiveness of Hyaluronic acid as adjunction treatment to scaling and root planning and scaling and root planning alone.Comparison between clinical measurement before and after treatment. Evaluate the level of IGF-1 in treated site as immunological marker if periodontal regeneration., conditionsModule conditions: Periodontitis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 24, type: ESTIMATED, armsInterventionsModule interventions name: Hyaluronic acid, interventions name: scaling and root planning, outcomesModule primaryOutcomes measure: Changes in Plaque Index, primaryOutcomes measure: Changes in Gingival Index, primaryOutcomes measure: Changes in Papillary Bleeding Index., primaryOutcomes measure: Periodontal Probing Depth, primaryOutcomes measure: Clinical attachment loss, primaryOutcomes measure: Changes in IGF-1, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Sana'a university, city: Sana'a, country: Yemen, geoPoint lat: 15.35472, lon: 44.20667, hasResults: False
protocolSection identificationModule nctId: NCT06324448, orgStudyIdInfo id: PD-tDCS-RCT, briefTitle: Self-administered tDCS for Improving Single- and Dual-task Gait in Patients With PD, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-15, primaryCompletionDateStruct date: 2025-02-01, completionDateStruct date: 2025-02-28, studyFirstPostDateStruct date: 2024-03-22, lastUpdatePostDateStruct date: 2024-03-26, sponsorCollaboratorsModule leadSponsor name: Seoul National University Hospital, class: OTHER, descriptionModule briefSummary: The purpose of this study is to investigate the efficacy and safety of self-administered transcranial direct current stimulation to improve the single- and dual-task gait in patients with Parkinson's disease., conditionsModule conditions: Parkinson Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: A randomized controlled trial, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 24, type: ESTIMATED, armsInterventionsModule interventions name: Transcranial direct current stimulation, outcomesModule primaryOutcomes measure: Timed-up and go test (sec), primaryOutcomes measure: Timed-up and go test under dual-task condition (sec), secondaryOutcomes measure: Dual-task effect (%) in Timed-up and go test, secondaryOutcomes measure: modified Attention Allocation Index (mAAI) in Timed-up and go test, secondaryOutcomes measure: Gait parameters, secondaryOutcomes measure: Single-leg stance test, secondaryOutcomes measure: Stroop test, secondaryOutcomes measure: Trail making test, secondaryOutcomes measure: New freezing of gait questionnaire (NFoGQ), secondaryOutcomes measure: Geriatric depression scale (GDS)-short form, secondaryOutcomes measure: Timed-up and go test (sec), secondaryOutcomes measure: Timed-up and go test under dual-task condition (sec), secondaryOutcomes measure: Dual-task effect (%) in Timed-up and go test, secondaryOutcomes measure: modified Attention Allocation Index (mAAI) in Timed-up and go test, secondaryOutcomes measure: Gait parameters, secondaryOutcomes measure: Single-leg stance test, secondaryOutcomes measure: Stroop test, secondaryOutcomes measure: Trail making test, secondaryOutcomes measure: New freezing of gait questionnaire (NFoGQ), secondaryOutcomes measure: Geriatric depression scale (GDS)-short form, eligibilityModule sex: ALL, minimumAge: 19 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Seoul National University Hospital, status: RECRUITING, city: Seoul, zip: 03080, country: Korea, Republic of, contacts name: Han Gil Seo, MD, role: CONTACT, phone: 82-2-2072-1659, email: hgseo80@gmail.com, geoPoint lat: 37.566, lon: 126.9784, hasResults: False
protocolSection identificationModule nctId: NCT06324435, orgStudyIdInfo id: 2000037439, secondaryIdInfos id: U54AA027989, type: NIH, link: https://reporter.nih.gov/quickSearch/U54AA027989, briefTitle: Apremilast for Alcohol Use Disorder Treatment in Women and Men, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-15, primaryCompletionDateStruct date: 2025-02-28, completionDateStruct date: 2025-02-28, studyFirstPostDateStruct date: 2024-03-22, lastUpdatePostDateStruct date: 2024-03-22, sponsorCollaboratorsModule leadSponsor name: Yale University, class: OTHER, collaborators name: National Institute on Alcohol Abuse and Alcoholism (NIAAA), collaborators name: Office of Research on Women's Health (ORWH), descriptionModule briefSummary: For this protocol, the investigators plan to collect pilot data to evaluate apremilast (60mg/day) in adults with Alcohol Use Disorders (AUD)., conditionsModule conditions: Alcohol Use Disorder, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: Apremilast, outcomesModule primaryOutcomes measure: Alcohol Consumption, eligibilityModule sex: ALL, minimumAge: 21 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06324409, orgStudyIdInfo id: H-350, briefTitle: ImmigrantScreen Telephone Reminder Trial in Colorectal Cancer Screening, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-22, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2025-03-30, studyFirstPostDateStruct date: 2024-03-22, lastUpdatePostDateStruct date: 2024-03-25, sponsorCollaboratorsModule leadSponsor name: Norwegian Institute of Public Health, class: OTHER_GOV, descriptionModule briefSummary: The goal of this randomized trial is to test the effect of a reminder telephone call in the official native language in the country where the invitee is born, in addition to the reminder letter in Norwegian on participation in the National Colorectal Cancer Screening Program in Pakistani and Somalian immigrants, compared to the reminder letter in Norwegian only.The main question it aims to answer is:•Does a reminder telephone call in the language of origin increase participation in colorectal cancer screening in Pakistani and Somalian immigrants in Norway?Participants in this trial are individuals with Pakistan or Somalia as their country of birth invited to the National Colorectal Cancer Screening Program, who have not participated by mailing a faecal sample to the screening laboratory.In the intervention group, the participants will be called in the official language in their country of origin, to inform about colorectal cancer screening, in addition to the reminder letter in Norwegian language sent to all non-participants.Participants in the comparison group will only be sent the reminder letter in Norwegian language.The researchers will compare differences in the participation rate in the National Colorectal Cancer Screening Program between the intervention and comparison groups., conditionsModule conditions: Cancer Colorectal, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: There is an intervention group and a comparison group in the study., primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: NONE, enrollmentInfo count: 600, type: ESTIMATED, armsInterventionsModule interventions name: Reminder telephone call, outcomesModule primaryOutcomes measure: First round screening participation, secondaryOutcomes measure: Overall screening participation, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06324396, orgStudyIdInfo id: STUDY00002974, briefTitle: IMProving DRug Dosing and Outcomes for Single VEntricle Patients With Fontan Associated Liver Disease, acronym: IMPROVE-FALD, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-03-22, lastUpdatePostDateStruct date: 2024-03-22, sponsorCollaboratorsModule leadSponsor name: Children's Mercy Hospital Kansas City, class: OTHER, collaborators name: Indiana Clinical and Translational Sciences Institute, descriptionModule briefSummary: This is a single center, open-label, prospective, investigation to quantify the effects liver congestion and fibrosis has on hepatic drug metabolism and transport in children, adolescents, and young adults with Fontan circulation., conditionsModule conditions: Fontan Circulation, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: This is a single center, open-label, prospective, investigation to quantify the effects of liver congestion and fibrosis has on hepatic statin transport (SA1) and response (SA2) in children, adolescents, and young adults with Fontan circulation., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 15, type: ESTIMATED, armsInterventionsModule interventions name: Sildenafil 10mg oral tablet (participants <20kg), or 20mg oral tablet (participants ≥20kg), interventions name: Pravastatin 20 mg oral tablet (ages <13 years), or 40 mg oral tablet (≥14 years), outcomesModule primaryOutcomes measure: Sildenafil concentration as measured by area under the curve (AUC), primaryOutcomes measure: Pravastatin concentration as measured by area under the curve (AUC), eligibilityModule sex: ALL, minimumAge: 8 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Children's Mercy Hospital, status: RECRUITING, city: Kansas City, state: Missouri, zip: 64108, country: United States, contacts name: Jonathan Wagner, DO, role: CONTACT, contacts name: Jonathan Wagner, DO, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.09973, lon: -94.57857, hasResults: False
protocolSection identificationModule nctId: NCT06324383, orgStudyIdInfo id: 1782599, briefTitle: Enhancing Purpose and Well-Being Through a Volunteering Experience Connecting Veterans With English Language Learners, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-28, primaryCompletionDateStruct date: 2025-03-28, completionDateStruct date: 2025-03-28, studyFirstPostDateStruct date: 2024-03-22, lastUpdatePostDateStruct date: 2024-03-22, sponsorCollaboratorsModule leadSponsor name: University of Michigan, class: OTHER, descriptionModule briefSummary: The goal of this study is to refine and test a strategy for engaging Veterans with symptoms of depression, anxiety, and/or PTSD as volunteers to help English language learners (ELLs) improve their speaking skills via structured conversations using videoconferencing., conditionsModule conditions: Depression, Anxiety, PTSD, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: NONE, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Intervention (videoconferencing), outcomesModule primaryOutcomes measure: France and Finney "Mattering", primaryOutcomes measure: (Patient Health Questionnaire) PHQ-8, primaryOutcomes measure: (Generalized Anxiety Disorder) GAD-7, primaryOutcomes measure: (Posttraumatic Stress Disorder Checklist) PCL-5, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Center for Clinical Management Research (CCMR), North Campus Research Complex, city: Ann Arbor, state: Michigan, zip: 48109, country: United States, geoPoint lat: 42.27756, lon: -83.74088, documentSection largeDocumentModule largeDocs typeAbbrev: ICF, hasProtocol: False, hasSap: False, hasIcf: True, label: Informed Consent Form, date: 2023-12-28, uploadDate: 2024-03-12T11:49, filename: ICF_000.pdf, size: 166776, hasResults: False
protocolSection identificationModule nctId: NCT06324331, orgStudyIdInfo id: Decidual sparing & CS niche, briefTitle: Effect of Decidual Sparing in cs Niche Formation, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2025-09-01, completionDateStruct date: 2025-12-01, studyFirstPostDateStruct date: 2024-03-21, lastUpdatePostDateStruct date: 2024-03-21, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: Assessing the impact of endometrial sparing at double-layer uterine closure as a specific surgical technique in CS to reduce the rate of post-cessarian delivery niche develoment, conditionsModule conditions: Cesarean Section Complications, conditions: Cesarean Section Niche, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: SCREENING, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, enrollmentInfo count: 184, type: ESTIMATED, armsInterventionsModule interventions name: Decidual sparing, interventions name: Non decidual sparing, outcomesModule primaryOutcomes measure: Impact of decidual sparing on niche formation, secondaryOutcomes measure: Impact of uterine closure technique on post CS niche criteria, eligibilityModule sex: FEMALE, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06324305, orgStudyIdInfo id: SRF drainage techniques in RRD, briefTitle: Comparative Study Between Three Different Techniques in Drainage of SRF During PPV in RRD, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2024-12, completionDateStruct date: 2025-04, studyFirstPostDateStruct date: 2024-03-21, lastUpdatePostDateStruct date: 2024-03-21, sponsorCollaboratorsModule leadSponsor name: Ain Shams University, class: OTHER, descriptionModule briefSummary: The study will investigate and compare the three techniques in drainage of subretinal fluid in patients with macula off RRD: namely using the original break, performing a posterior drainage retinotomy and using PFC with drainage through the original break or peripheral retinotomy regarding the presence of persistent sub-retnal fluid and related intra or postoperative complications, conditionsModule conditions: Rhegmatogenous Retinal Detachment, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 66, type: ESTIMATED, armsInterventionsModule interventions name: Pars plana vitrectomy (PPV) and drainage of subretinal fluid, outcomesModule primaryOutcomes measure: The presence versus absence of sub-macular fluid using each of the three different techniques in pars plana vitrectomy (PPV), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False