protocolSection identificationModule nctId: NCT06278662, orgStudyIdInfo id: CIRCUS cmRCT, briefTitle: Cohort Multiple Randomized Controlled Trial in Pediatric Asthma, acronym: CIRCUS, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2034-04-01, completionDateStruct date: 2034-04-01, studyFirstPostDateStruct date: 2024-02-26, lastUpdatePostDateStruct date: 2024-02-26, sponsorCollaboratorsModule leadSponsor name: Mattienne van der Kamp, class: OTHER, descriptionModule briefSummary: The overarching goal of this study is to optimize pediatric asthma care and to continuously evaluate variations/innovations of the care (including transformation to remote eHealth care).Primary Objectives within cmRCT cohort:* Provide a framework for multiple randomized (eHealth) interventions for asthmatic children* Generate short- and long-term data on Quality of life (QoL), asthma outcomes (asthma control, lung function), quality of care, self-management capacity, healthcare use, and therapy compliance in a representative secondary care pediatric asthma cohort.Secondary Objectives within cmRCT cohort:* Evaluate current pediatric asthma care at the Pediatric department of Medisch Spectrum Twente, in order to explore possible improvements for the pediatric asthma care.* Compare the short and long-term asthma outcomes between the eHealth care path and the outpatient care path.* Compose patient risk profiles that include both personal, clinical and exposome markers and clinical asthma endpoints (for example clinical admission/exacerbations)., conditionsModule conditions: Pediatric Asthma, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: The CIRCUS study has a cmRCT design to determine the effects of (eHealth) interventions in asthmatic children. Children are included in the prospective dynamic cohort during outpatient visits. Children and/or their parents are asked to sign consent for three parts of the cmRCT, of which at least consent for part 1 is needed to be eligible for participation:1. Participating in the prospective dynamic cohort and data collection.2. Willingness to participate in interventions.3. Willingness to fill out additional questionnaires and/or do additional measurements if a child is randomly selected for the control group of an intervention, which uses additional outcomes., primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, maskingDescription: The masking is dependent of the future interventions., enrollmentInfo count: 300, type: ESTIMATED, armsInterventionsModule interventions name: video directly observed therapy (vDOT), outcomesModule primaryOutcomes measure: Asthma control, primaryOutcomes measure: Pediatric Asthma Quality of Life, primaryOutcomes measure: Quality of care, primaryOutcomes measure: Self-management capacity, primaryOutcomes measure: Healthcare use, primaryOutcomes measure: Wheather data, primaryOutcomes measure: Air quality, primaryOutcomes measure: Pollen, primaryOutcomes measure: Medication delivery, eligibilityModule sex: ALL, minimumAge: 4 Years, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule, hasResults: False