protocolSection identificationModule nctId: NCT06354881, orgStudyIdInfo id: 0967, secondaryIdInfos id: TM61008S3, type: OTHER_GRANT, domain: British Heart Foundation, briefTitle: The Relationship Between Controlling Risk Factors and Cerebral Haemodynamics in Lacunar Stroke, acronym: LACUNAR_CA, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2026-03, completionDateStruct date: 2026-03, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: University of Leicester, class: OTHER, collaborators name: British Heart Foundation, collaborators name: University Hospitals, Leicester, descriptionModule briefSummary: The goal of this observational study is to look at differences in brain blood flow before and after management of risk factors such as high blood pressure and diabetes in patients with lacunar stroke. Participants will be asked to undergo a simple brain blood flow assessment at their initial appointment, whereby they will be asked to sit and stand twice. The patients will then be asked for a follow-up assessment 4 weeks after, identical to the first. This will allow us to look at any changes in brain blood flow from before management of risk factors and 4 weeks after management of risk factors., conditionsModule conditions: Lacunar Stroke, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 75, type: ESTIMATED, armsInterventionsModule interventions name: Transcranial Doppler Ultrasonography (TCD) during sit-stand manoeuvres, outcomesModule primaryOutcomes measure: Cerebral blood velocity measurements before and after management of uncontrolled risk-factors in those diagnosed with lacunar stroke syndromes., primaryOutcomes measure: Arterial blood pressure measurements before and after management of uncontrolled risk-factors in those diagnosed with lacunar stroke syndromes., primaryOutcomes measure: Heart rate measurements before and after management of uncontrolled risk-factors in those diagnosed with lacunar stroke syndromes., primaryOutcomes measure: End-tidal carbon dioxide measurements before and after management of uncontrolled risk-factors in those diagnosed with lacunar stroke syndromes., primaryOutcomes measure: Compare cerebral haemodynamics in lacunar stroke patients with older patients experiencing advanced chronic cerebrovascular disease with lacunar stroke syndromes, whose risk-factors are already managed.(CA)., primaryOutcomes measure: Compare cerebral haemodynamics in lacunar stroke patients with older patients experiencing advanced chronic cerebrovascular disease with lacunar stroke syndromes, whose risk-factors are already managed. (VMR)., primaryOutcomes measure: Compare cerebral haemodynamics in lacunar stroke patients with older patients experiencing advanced chronic cerebrovascular disease with lacunar stroke syndromes, whose risk-factors are already managed.(ARI)., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University Hospitals of Leicester NHS Trust, city: Leicester, state: Leicestershire, zip: LE1 5WW, country: United Kingdom, contacts name: Amit Mistri, role: CONTACT, email: amit.mistri@uhl-tr.nhs.uk, geoPoint lat: 52.6386, lon: -1.13169, hasResults: False