protocolSection identificationModule nctId: NCT06335082, orgStudyIdInfo id: DISRUPT-AF, briefTitle: A Registry Based Collaborative to Measure Efficiency, Effectiveness, and Safety of Farapulse PFA Technology for AF, acronym: DISRUPT-AF, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-15, primaryCompletionDateStruct date: 2026-11-30, completionDateStruct date: 2027-01-30, studyFirstPostDateStruct date: 2024-03-28, lastUpdatePostDateStruct date: 2024-04-11, sponsorCollaboratorsModule leadSponsor name: Heart Rhythm Clinical and Research Solutions, LLC, class: OTHER, collaborators name: Boston Scientific Corporation, descriptionModule briefSummary: The DISRUPT-AF Registry is an observational, prospective, multi-center, non-randomized, real-world registry designed to obtain clinical experience with the Farapulse Pulsed Field Ablation System for the treatment of atrial fibrillation (AF)., conditionsModule conditions: Atrial Fibrillation, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 900, type: ESTIMATED, armsInterventionsModule interventions name: Pulsed Field Ablation, outcomesModule primaryOutcomes measure: Long term effectiveness, primaryOutcomes measure: Long-term safety, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Arrhythmia Institute at Grandview, city: Birmingham, state: Alabama, zip: 35243, country: United States, contacts name: Anil Rajendra, MD, role: CONTACT, phone: 205-971-7578, email: arajendra@alcardio.com, contacts name: Susan Thorington, role: CONTACT, phone: 205-971-7578, email: susan.thorington@grandviewhealth.com, contacts name: Anil Rajendra, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.52066, lon: -86.80249, locations facility: Community Memorial Health Systems, city: Ventura, state: California, zip: 93003, country: United States, contacts name: Jonathan Dukes, MD, role: CONTACT, phone: 805-653-0101, email: jonathan_dukes@mac.com, contacts name: Jennifer Freeland, role: CONTACT, phone: 805-948-8278, email: jfreeland@cmhshealth.org, contacts name: Jonathan Dukes, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.27834, lon: -119.29317, locations facility: Endeavor Health (Northshore), city: Glenview, state: Illinois, zip: 60026, country: United States, contacts name: Mark Metzl, MD, role: CONTACT, phone: 847-570-2640, email: mmetzl@northshore.org, contacts name: Marisa Durante, role: CONTACT, phone: 847-687-8527, email: mdurante@northshore.org, contacts name: Mark Metzl, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.06975, lon: -87.78784, locations facility: Brigham and Women's Hospital, city: Boston, state: Massachusetts, zip: 02115, country: United States, contacts name: Jorge Romero, MD, role: CONTACT, phone: 617-732-5241, email: jeromero@bwh.harvard.edu, contacts name: Fernando Moreno, role: CONTACT, phone: 617-732-5241, email: fmoreno2@bwh.harvard.edu, contacts name: Jorge Romero, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.35843, lon: -71.05977, locations facility: Cardiovascular Associates of Delaware Valley, city: Haddon Heights, state: New Jersey, zip: 08035, country: United States, contacts name: George Mark, MD, role: CONTACT, phone: 856-546-3003, email: gmark4@yahoo.com, contacts name: Erin Siderio, role: CONTACT, phone: 856-582-2000, phoneExt: 5207, email: esiderio@hearthousenj.com, contacts name: George Mark, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.87734, lon: -75.06462, locations facility: Texas Cardiac Arrhythmia Research Foundation (St. Davids), city: Austin, state: Texas, zip: 78705, country: United States, contacts name: Andrea Natale, MD, role: CONTACT, phone: 512-522-9410, email: tcarfan@gmail.com, contacts name: Deb Cardinal, RN, role: CONTACT, phone: 512-431-4868, email: dscardinal@austinheartbeat.com, contacts name: Andrea Natale, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.26715, lon: -97.74306, hasResults: False