hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06286046, orgStudyIdInfo id: AG348-C-026, secondaryIdInfos id: 2023-510289-28-00, type: OTHER, domain: EU Clinical Trial Number, briefTitle: A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathy, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06, primaryCompletionDateStruct date: 2026-05, completionDateStruct date: 2027-09, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-04-12, sponsorCollaboratorsModule leadSponsor name: Agios Pharmaceuticals, Inc., class: INDUSTRY, descriptionModule briefSummary: The primary purpose of this study is to evaluate the effect of mitapivat on albumin creatinine ratio (ACR) response in participants with sickle cell disease (SCD) and nephropathy., conditionsModule conditions: Sickle Cell Disease, conditions: Nephropathy, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Mitapivat, outcomesModule primaryOutcomes measure: Percentage of Participants With Albumin Creatinine Ratio (ACR) Response, secondaryOutcomes measure: Change From Baseline in Cystatin C and Creatinine-based Estimated Glomerular Filtration Rate (eGFRcr-cys), secondaryOutcomes measure: Change From Baseline in Albumin Creatinine Ratio (ACR), secondaryOutcomes measure: Percentage of Participants With Stable ACR, secondaryOutcomes measure: Annualized Rate of Emergency Room (ER) Visits, secondaryOutcomes measure: Annualized Rate of Days of Hospitalizations, secondaryOutcomes measure: Type, Frequency, Severity, and Relationship to Study Drug of Adverse Events (AEs) and Serious Adverse Events (SAEs), eligibilityModule sex: ALL, minimumAge: 16 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06286020, orgStudyIdInfo id: VR-Zhenqiu, briefTitle: Effect of Virtual Reality Therapy on Dysphagia in Wallenberg Syndrome, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-28, primaryCompletionDateStruct date: 2024-07, completionDateStruct date: 2024-07, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-06, sponsorCollaboratorsModule leadSponsor name: Zeng Changhao, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to learn about on dysphagia in wallenberg syndrome. The main questions it aims to answer are:the efficacy of Virtual Reality Therapy in the rehabilitation of patients with dysphagia in Wallenberg syndrome.Participants received conventional dysphagia treatment and Virtual Reality Therapy once a day for 14 days. Researchers compared the control group to see the effect and mechanism of Virtual Reality Therapy., conditionsModule conditions: Wallenberg Syndrome, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Virtual Reality Therapy, interventions name: Conventional dysphagia treatment, outcomesModule primaryOutcomes measure: standardized swallowing assessment, secondaryOutcomes measure: Murray secretion scale, secondaryOutcomes measure: Rosenbek penetration-aspiration scale, secondaryOutcomes measure: swallowing-quality of life, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 85 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Xinzhu Rehabilitation Hospital, status: RECRUITING, city: Xinzhu, country: Taiwan, contacts name: Haim Liu, role: CONTACT, geoPoint lat: 22.46205, lon: 120.47335, hasResults: False
protocolSection identificationModule nctId: NCT06285994, orgStudyIdInfo id: SRB2024016, briefTitle: Complications of High Frequency Jet Ventilation, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-20, primaryCompletionDateStruct date: 2024-08-31, completionDateStruct date: 2024-10-31, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-04-24, sponsorCollaboratorsModule leadSponsor name: Erasme University Hospital, class: OTHER, descriptionModule briefSummary: High frequency jet ventilation (HFJV) has been introduced in 1967 as technique allowing ventilation with simultaneous access to the airway for bronchoscopy. Continuous improvement in the technique has led to a large use during interventional bronchoscopy, especially in large centers. However, complications occuring during the use of HFJV are poorly known. In this retrospective cohort study, the charts of all patients who had a bronchoscopy with the use of HFJV between 2019 and 2023 in our hospital will be analyzed. Primary outcome will the description of all complications during HFJV. Complications are defined as:* Hypoxia: SpO2 \< 90% for 1 min* Severe hypoxia: SpO2 \< 85% for 1 min* Hemodynamic instability, defined as Arterial pressure \< 90/60* Cardiac arrhythmia* Laryngospasm or bronchospasm* Barotrauma or volutrauma* Need for ICU admissionA model predicting the risk for developing any complication will be developped using 2 mathematical methods:* a multivariate analysis* a data mining approachFor both approaches, the following variables will be included in the model:* Age* Gender* Weight* Height* BMI* Smoking* Alcohol consumption* Consumption of Other drugs* ASA class* Obstructive pulmonary disease* Restrictive lung disease* COPD status (1, 2, 3, 4)* Interstitial lung disease* Lung tumor  * Trachea location  * Carina location  * Bronchial location* Pulmonary or tracheal stenosis* Presence of stridor* Severe stenosis (\< 6 mm)* Baseline SpO2 (pre-intervention)* Pre-intervention oxygen requirement Procedure* Duration (min)* Stent placement* Dilation* Laser treatment* Length of hospital stay Lung function tests* FEV1 (forced expiratory volume)* VC (Vital Capacity)* FEV1/VC (Tiffeneau ratio)* CPT (total lung capacity)* DLCO (carbon monoxide diffusion), conditionsModule conditions: High-Frequency Jet Ventilation, conditions: Bronchoscopy, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 1200, type: ESTIMATED, armsInterventionsModule interventions name: High frequency jet ventilation, outcomesModule primaryOutcomes measure: Occurence of complications, secondaryOutcomes measure: Prediction model of complications, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hôpital Universitaire de Bruxelles - Hôpital erasme, status: RECRUITING, city: Brussels, zip: 1070, country: Belgium, contacts name: Denis Schmartz, MD, role: CONTACT, phone: +3225553919, email: denis.schmartz@hubruxelles.be, geoPoint lat: 50.85045, lon: 4.34878, hasResults: False
protocolSection identificationModule nctId: NCT06285981, orgStudyIdInfo id: OCI_2206, briefTitle: Retrospective Study Chimaera Long Nail in Adult Patient, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-27, primaryCompletionDateStruct date: 2024-06-30, completionDateStruct date: 2024-06-30, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-04-12, sponsorCollaboratorsModule leadSponsor name: Orthofix s.r.l., class: INDUSTRY, descriptionModule briefSummary: The CHIMERA study intends to evaluate the clinical benefits of the study medical device in the standard clinical practice., conditionsModule conditions: Pertrochanteric Fracture of Femur, conditions: Intertrochanteric Fracture of Femur, conditions: Subtrochanteric Fracture of Femur, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 44, type: ESTIMATED, armsInterventionsModule interventions name: Chimaera Long Nail, outcomesModule primaryOutcomes measure: percent of patients in wich bone union has been achieved, secondaryOutcomes measure: percent of patients that required a reoperation, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: AORN Sant'Anna e San Sebastiano, status: NOT_YET_RECRUITING, city: Caserta, state: CE, zip: 81100, country: Italy, contacts name: Gaetano Bruno, role: CONTACT, phone: 0823 232111, geoPoint lat: 41.07262, lon: 14.33231, locations facility: Craeggi Hospital, status: RECRUITING, city: Florence, state: FI, zip: 50134, country: Italy, contacts name: Roberto Civinini, role: CONTACT, phone: 055 794 111, geoPoint lat: 43.77925, lon: 11.24626, hasResults: False
protocolSection identificationModule nctId: NCT06285955, orgStudyIdInfo id: 307-reinforced teeth, briefTitle: Clinical Trial of Metal-Reinforced Teeth Designed for Endoscopic Clips, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-15, primaryCompletionDateStruct date: 2024-07-31, completionDateStruct date: 2024-08-31, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Beijing 302 Hospital, class: OTHER, descriptionModule briefSummary: Postoperative gastrointestinal complications following ESD, EMR, and EFTR procedures, such as gastrointestinal bleeding, diverticula, fistulas, perforations, and stent fixation, can be effectively treated through gradual endoscopic procedures. The technical limitations of traditional endoscopic hemoclips restrict their application. Although endoscopic suturing techniques are emerging, most are still in the exploratory phase. Therefore, the investigators have developed metal-reinforced teeth for hemoclips. This initial clinical study aims to validate the safety, feasibility, and effectiveness of reinforced teeth in clinical applications. The investigators also aim to explore the uses and limitations of this technology. The primary outcomes are the technical success rate and the clinical success rate., conditionsModule conditions: Pilot Study, conditions: Clips, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: PROSPECTIVE, enrollmentInfo count: 10, type: ESTIMATED, outcomesModule primaryOutcomes measure: Clinical success rate, secondaryOutcomes measure: Technical success rate, secondaryOutcomes measure: Delayed bleeding rate, secondaryOutcomes measure: Delayed perforation rate, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The fifth Medical Center of Chinese PLA General Hospital, status: RECRUITING, city: Beijing, state: Beijing, zip: 100071, country: China, contacts name: Jindong Chu, MD, role: CONTACT, phone: +8615811201126, email: chu465292278@163.com, contacts name: Shuqian Hu, role: CONTACT, phone: +8618526504112, email: 1811045@mail.nankai.edu.cn, contacts name: Yan Liu, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False
protocolSection identificationModule nctId: NCT06285903, orgStudyIdInfo id: AUAREC20220002-11, briefTitle: Comparing the Hydrodynamic Piezoelectric Technique With Osseodensification for the Assessment of Internal Sinus Iift-ing, acronym: RCT, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-09-02, primaryCompletionDateStruct date: 2022-12-01, completionDateStruct date: 2023-12-30, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-28, sponsorCollaboratorsModule leadSponsor name: Al-Azhar University, class: OTHER, descriptionModule briefSummary: Successful osseointegration considered the cornerstone in implant stability which predict the highest implants success outcomes. Implant stability depend on many factors like the implant design, surgical technique, and bone density. Posterior maxilla considered as a challenging area in implant placement, this is due to less dense trabecular bone sur-rounded by a thin layer of cortical bone which result in suffering in implant stability. The aim of this study is to evaluate the bone density outcomes using bone densification technique and piezoelectric surgical technique in sinus lift to promote bone gain, conditionsModule conditions: Bone Density, Low, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: A total of 20 patients were randomly divided into two groups: Group1: patients received dental implant using osseodensification via Densah bur, Group2: patients received dental implant using hydrodynamic piezoelectric sinus lifting. The patients in both groups underwent bone grafting under sinus membrane. Modified bleeding index and probing depth were evaluated at 3, 6 and 12months intervals. An Osstell device was used to de-termine implant stability by recording the values of implant stability quotient (ISQ) im-mediately after implant placement and after 3 months. CBCT was performed before, af-ter 6 months and after 12 months to evaluate ridge height, bone density. Marginal bone loss was evaluated after 3 months via periapical radiograph, after 6 months and after 12 months via CBCT., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ACTUAL, armsInterventionsModule interventions name: internal sinus lift surgery, outcomesModule primaryOutcomes measure: Implant stability using the Osstell device by percentage, secondaryOutcomes measure: Modified sulcus bleeding index,Peri-implant pocket depth (PPD)by mm, otherOutcomes measure: Bone Densityby mm, eligibilityModule sex: ALL, minimumAge: 35 Years, maximumAge: 39 Years, stdAges: ADULT, contactsLocationsModule locations facility: Alazhar university ,Assuit branch ,Egypt, city: Assiut, state: Assuit, zip: 0000, country: Egypt, geoPoint lat: 27.18096, lon: 31.18368, hasResults: False
protocolSection identificationModule nctId: NCT06285890, orgStudyIdInfo id: 2023-1016, secondaryIdInfos id: NCI-2024-01733, type: OTHER, domain: NCI-CTRP Clinical Registry, briefTitle: Phase I Study of HC-7366 With Azacitidine and Venetoclax for Acute Myeloid Leukemia, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-08-31, primaryCompletionDateStruct date: 2027-12-31, completionDateStruct date: 2029-12-31, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-04-12, sponsorCollaboratorsModule leadSponsor name: M.D. Anderson Cancer Center, class: OTHER, collaborators name: HiberCell, Inc., descriptionModule briefSummary: To find a recommended dose of HC-7366 that can be given in combination with azacitidine and venetoclax to patients with AML. The safety and effects of this drug combination will also be studied., conditionsModule conditions: Acute Myeloid Leukemia, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 18, type: ESTIMATED, armsInterventionsModule interventions name: HC-7366, interventions name: Azacitidine, interventions name: Venetoclax, outcomesModule primaryOutcomes measure: Safety and adverse events (AEs), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: MD Anderson Cancer Center, city: Houston, state: Texas, zip: 77030, country: United States, contacts name: Abhishek Maiti, MD, role: CONTACT, phone: 346-725-0901, email: amaiti@mdanderson.org, contacts name: Abhishek Maiti, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.76328, lon: -95.36327, hasResults: False
protocolSection identificationModule nctId: NCT06285877, orgStudyIdInfo id: 291120234382023, briefTitle: Effectiveness of the Use of the Nintendo Switch Combined With Conventional Therapy in People With Acquired Brain Injury, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02, primaryCompletionDateStruct date: 2024-02, completionDateStruct date: 2025-01, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Universidad Rey Juan Carlos, class: OTHER, descriptionModule briefSummary: Purpose: to observe the possible benefits produced by conventional therapy through virtual reality with the Nintendo Switch to try to improve motivation and increase the degree of care satisfaction. The aim is to improve postural control in both seated and standing positions and to maintain and improve cognitive capacity.Material and methods: one group (experimental group) will receive a total of 8 one-hour sessions or 16 half-hour sessions, depending on their individual needs, for 8 weeks using the Nintendo Switch. The other group (control group) will continue to receive their conventional scheduled therapy.Measures: Abilhand, MEC-Lobo, FIST, Fugl-Meyer, Berg Balance Scale and CSQ-8., conditionsModule conditions: Occupational Therapy, conditions: Acquired Brain Injury, conditions: Adults, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Control Group (CG), which received their usual sessions of conventional therapy sessions, and an Experimental Group (EG), which received therapy with Nintendo Switch plus their conventional therapy sessions., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 32, type: ESTIMATED, armsInterventionsModule interventions name: Conventional therapy sessions, interventions name: Conventional therapy sessions plus Nintendo Switch, outcomesModule primaryOutcomes measure: Abilhand, primaryOutcomes measure: MEC-Lobo, primaryOutcomes measure: Function in Sitting Test (FIST), primaryOutcomes measure: Fugl-Meyer, primaryOutcomes measure: Berg Balance Scale (BBS), secondaryOutcomes measure: Client Satisfaction Questionnaire (CSQ-8), eligibilityModule sex: ALL, minimumAge: 30 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Universidad Rey Juan Carlos, status: RECRUITING, city: Móstoles, state: Madrid, zip: 28933, country: Spain, contacts name: Isabel Quirosa Galan, MsC, role: CONTACT, phone: +34655551210, email: i.quirosa.2016@alumnos.urjc.es, geoPoint lat: 40.32234, lon: -3.86496, hasResults: False
protocolSection identificationModule nctId: NCT06285851, orgStudyIdInfo id: 23-0825, briefTitle: A Novel Iron Supplement for Athletes: Phase I, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-11-23, primaryCompletionDateStruct date: 2023-12-12, completionDateStruct date: 2023-12-12, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-28, sponsorCollaboratorsModule leadSponsor name: University of Calgary, class: OTHER, collaborators name: Lallemand Bio-Ingredients, descriptionModule briefSummary: Female endurance athletes are susceptible to iron deficiency and this can impact their exercise performance. This study is a pilot trial to assess the tolerability of a novel iron supplement prior to conducting a clinical trial on the efficacy of the developed novel iron supplement on iron status and performance., conditionsModule conditions: Constipation, conditions: Diarrhea, conditions: Cramp, Abdominal, conditions: Bleeding Gastric, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 14, type: ACTUAL, armsInterventionsModule interventions name: FeSC, outcomesModule primaryOutcomes measure: GI Symptoms, primaryOutcomes measure: Gastrointestinal symptoms, secondaryOutcomes measure: Supplement Tolerability and Preferences Questionnaire, secondaryOutcomes measure: Recovery, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 25 Years, stdAges: ADULT, contactsLocationsModule locations facility: University of Calgary, city: Calgary, state: Alberta, country: Canada, geoPoint lat: 51.05011, lon: -114.08529, hasResults: False
protocolSection identificationModule nctId: NCT06285838, orgStudyIdInfo id: 2020/2706, briefTitle: Impact of Measures Taken to Contain COVID-19 on Hospital Surgical Care Services and Clinical Outcomes, statusModule overallStatus: COMPLETED, startDateStruct date: 2020-07-17, primaryCompletionDateStruct date: 2023-11-30, completionDateStruct date: 2024-01-20, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Singapore Health Services, class: OTHER, descriptionModule briefSummary: Swift and decisive actions on the part of healthcare and hospital authorities are required to effectively contain the current COVID-19 pandemic. These measures firstly allow personnel and facilities leeway to provide surge capabilities to meet anticipated increased demands on the healthcare service. In addition, by deferring none urgent hospital visits, admissions and investigations, such measures support social distancing and aid attempts to control disease transmission. Deferring perceived non-urgent patient services may however lead to unintended delayed diagnoses and exacerbation of current patient conditions and lead to increased emergency admissions and surgeries.A policy decision was made that essential surgical services pertaining to cancer and urgent cardiovascular surgery were allowed but that surgeons had the option to postpone what is assessed to be less urgent cases. Increasingly patients also postpone their surgeries or visits because of anxieties over the developing situation. Elective surgical services at the Outram Campus were thus significantly reduced from January 2020 as part of the measures to contain the COVID-19 outbreak.The surgical philosophy during this period was that a judicious policy that allowed surgeons to proceed with surgery deemed critical but to postpone those deemed less so will at the system level, avoid poor outcomes for patients who required surgery and yet successfully re-allocate resources required to address the unfolding pandemic., conditionsModule conditions: COVID-19, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 11000, type: ACTUAL, outcomesModule primaryOutcomes measure: Impact of measures taken to contain COVID-19 on hospital surgical care services and clinical outcomes, eligibilityModule sex: ALL, minimumAge: 21 Years, maximumAge: 100 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Singapore Health Services Pte ltd, city: Singapore, zip: 169856, country: Singapore, geoPoint lat: 1.28967, lon: 103.85007, hasResults: False