protocolSection identificationModule nctId: NCT06265506, orgStudyIdInfo id: 20320, secondaryIdInfos id: R01AA031013, type: NIH, link: https://reporter.nih.gov/quickSearch/R01AA031013, briefTitle: Virtual Incentive Treatment for Alcohol, acronym: VITA, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-02-19, primaryCompletionDateStruct date: 2027-04-03, completionDateStruct date: 2028-04-04, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-02-20, sponsorCollaboratorsModule leadSponsor name: Washington State University, class: OTHER, collaborators name: The University of Texas Health Science Center at San Antonio, collaborators name: Weill Medical College of Cornell University, collaborators name: National Institute on Alcohol Abuse and Alcoholism (NIAAA), descriptionModule briefSummary: The overall objective of this program of research is to utilize phosphatidylethanol (PEth), a blood-based biomarker that can detect alcohol use for up to 28 days to deliver a feasible telehealth-based 26-week CM intervention. This study will test a telehealth PEth-based CM model in a sample of adults with AUD (n=200), recruited via online platforms by randomizing individuals to six months of 1) an online cognitive behavioral therapy for AUD (CBT4CBT) and telehealth PEth-based CM (CM condition) or 2) CBT4CBT and reinforcers for submitting blood samples (no abstinence required) (control condition). Investigators will assess group differences in PEth-defined abstinence and regular excessive drinking (PEth \>= 200 ng/mL), and alcohol-related harms (e.g., smoking, drug use). This study will address important gaps in CM research by assessing outcomes during a 12-month follow-up, which is much longer than most previous CM studies; using a conceptual model to identify predictors of post-treatment abstinence. Investigators will conduct an economic analysis to place the cost of this model in the context of downstream CM-associated cost-offsets and improvements in personal and public health., conditionsModule conditions: Alcohol Use Disorder, conditions: Alcohol Drinking, conditions: Alcohol Abuse, conditions: Alcohol Dependence, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: We will test the efficacy of our CM model against an evidence-based online intervention, CBT4CBT, by randomizing participants to six months of:1. CBT4CBT and reinforcement for submitting blood samples (no requirement for abstinence) (Control Condition), or2. CBT4CBT and reinforcement for PEth tests that are consistent with alcohol abstinence (CM Condition)., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 200, type: ESTIMATED, armsInterventionsModule interventions name: Contingency Management, interventions name: Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT), outcomesModule primaryOutcomes measure: Aim 1) Alcohol Abstinence & Aim 3) Predictors: PEth-Defined Alcohol Abstinence During CM (Aim 1) and Follow-Up (Aim 3), primaryOutcomes measure: Aim 2) Alcohol-Related Harms: Addiction Severity Index (ASI) Lite, primaryOutcomes measure: Aim 2) Alcohol-Related Harms: Patient Health Questionnaire-9 (PHQ-9), primaryOutcomes measure: Aim 2) Alcohol-Related Harms: Generalized Anxiety Disorder-7 (GAD-7), primaryOutcomes measure: Aim 2) Alcohol-Related Harms: Short Form Health Survey-12 (SF-12), primaryOutcomes measure: Aim 2) Alcohol-Related Harms & Aim 4) Cost Analysis: Non-study Medical and Other Services (NMOS) form, primaryOutcomes measure: Aim 2) Alcohol Related Harms: Fagerstrom, primaryOutcomes measure: Aim 2) Alcohol Related Harms: Urine Drug Tests, primaryOutcomes measure: Aim 2) Alcohol Related Harms: Perceived Stress Scale (PSS-10), primaryOutcomes measure: Aim 3) Predictors: Demographics, primaryOutcomes measure: Aim 3) Predictors: Addictions Neuroclinical Assessment (ANA) Questionnaire, primaryOutcomes measure: Aim 3) Predictors: TestMyBrain, primaryOutcomes measure: Aim 3) Predictors: Positive Negative Affect Schedule (PANAS), primaryOutcomes measure: Aim 3) Predictors: Situational Confidence Questionnaire-8 (SCQ-8), primaryOutcomes measure: Aim 3) Predictors: Alcohol Craving VAS, primaryOutcomes measure: Aim 4) Cost Analysis: Drug Abuse Treatment Cost Analysis Program (DATCAP), primaryOutcomes measure: Aim 4) Cost Analysis: PROPr, secondaryOutcomes measure: Aim 1) Alcohol Abstinence: Regular excessive drinking, otherOutcomes measure: Aim 1) Alcohol Abstinence: uEtG-Defined Alcohol Abstinence, otherOutcomes measure: Aim 1) Alcohol Abstinence: Self-reported Alcohol Abstinence and Heavy Drinking, otherOutcomes measure: Additional Implementation Data: Attrition, otherOutcomes measure: Additional Implementation Data: CSQ-8, otherOutcomes measure: Adverse Events, otherOutcomes measure: Computer Based Training for Cognitive Behavioral Health (CBT4CBT) Program Use, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Washington State University, city: Spokane, state: Washington, zip: 99201, country: United States, contacts name: Michael McDonell, PhD, role: CONTACT, phone: 509-368-6967, email: mmcdonell@wsu.edu, geoPoint lat: 47.65966, lon: -117.42908, hasResults: False