hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06365411, orgStudyIdInfo id: GEM-KiT, briefTitle: GEnomic Medicine in Kidney Transplantation Study, acronym: GEM-KiT, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-03, primaryCompletionDateStruct date: 2030-01-01, completionDateStruct date: 2035-01-01, studyFirstPostDateStruct date: 2024-04-15, lastUpdatePostDateStruct date: 2024-04-24, sponsorCollaboratorsModule leadSponsor name: Western Sydney Local Health District, class: OTHER, descriptionModule briefSummary: Investigator led, prospective, observational cohort study to detect genomic features which can predict outcomes following kidney transplantation.1. Determine non-HLA genomic mismatches between donor-recipient pairs which impact kidney allograft survival following transplantation2. Derive polygenic risk scores on pre-transplant blood and/or kidney biopsy samples which predict kidney allograft dysfunction3. Derive polygenic risk scores on post-transplant blood and/or kidney biopsy samples which predict kidney allograft dysfunction, conditionsModule conditions: Transplant Complication, conditions: Kidney Transplant Rejection, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 1000, type: ESTIMATED, armsInterventionsModule interventions name: Biomarker discovery and validation - with focus on genomic biomarkers, outcomesModule primaryOutcomes measure: Death censored graft loss (DCGL), primaryOutcomes measure: Biopsy proven rejection (BPAR), secondaryOutcomes measure: All cause graft loss, secondaryOutcomes measure: Death, secondaryOutcomes measure: Treatment resistant rejection, secondaryOutcomes measure: Hospital admission or emergency attendance, secondaryOutcomes measure: Delayed Graft Function (DGF), secondaryOutcomes measure: Kidney function, secondaryOutcomes measure: Albuminuria, secondaryOutcomes measure: Surrogate end-point markers, secondaryOutcomes measure: Borderline rejeciton, secondaryOutcomes measure: chronic rejection; chronic transplant glomerulopathy; and interstitial fibrosis and tubular atrophy (IFTA) scores, secondaryOutcomes measure: Recurrent disease, secondaryOutcomes measure: BK virus complications, secondaryOutcomes measure: Major cardiovascular complications, secondaryOutcomes measure: Major infectious complications, secondaryOutcomes measure: Malignancy post transplantation, secondaryOutcomes measure: Kidney biopsy transcriptomic signature, secondaryOutcomes measure: Kidney cell type composition, secondaryOutcomes measure: Proteinomic signature, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06365372, orgStudyIdInfo id: MrgD and PAH, briefTitle: Circulating MrgD in Pulmonary Hypertension, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-10, primaryCompletionDateStruct date: 2024-05-10, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-04-15, lastUpdatePostDateStruct date: 2024-04-15, sponsorCollaboratorsModule leadSponsor name: Qilu Hospital of Shandong University, class: OTHER, descriptionModule briefSummary: The aim of the study is to observe the change of the circulating MrgD level in patients with pulmonary hypertension compared with subjects without pulmonary hypertension., conditionsModule conditions: Pulmonary Hypertension, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 90, type: ESTIMATED, armsInterventionsModule interventions name: Western blot, outcomesModule primaryOutcomes measure: Circulating MrgD level, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Qilu Hospital of Shandong University, status: RECRUITING, city: Jinan, state: Shandong, zip: 250012, country: China, contacts name: Panpan Hao, MD, PHD, role: CONTACT, email: panda.how@126.com, contacts name: Hongyu Zhong, MD, role: SUB_INVESTIGATOR, geoPoint lat: 36.66833, lon: 116.99722, hasResults: False
protocolSection identificationModule nctId: NCT06365346, orgStudyIdInfo id: 2024.075-T, briefTitle: Music Breathing Therapy for Children With Attention-deficit Hyperactivity Disorder and Their Caregivers, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-15, primaryCompletionDateStruct date: 2025-05-31, completionDateStruct date: 2025-08-31, studyFirstPostDateStruct date: 2024-04-15, lastUpdatePostDateStruct date: 2024-04-15, sponsorCollaboratorsModule leadSponsor name: Chinese University of Hong Kong, class: OTHER, descriptionModule briefSummary: This pilot randomized controlled trial aims to evaluate the feasibility (in terms of rates of recruitment, retention, and attendance), acceptability, and potential effects of the dyadic video-assisted gamified music breathing therapy on dyads' resilience, children's emotional and behavioral symptoms, parents' parenting stress, and psychological distress., conditionsModule conditions: Resilience, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 48, type: ESTIMATED, armsInterventionsModule interventions name: Dyadic video-assisted gamified group-based music breathing therapy, interventions name: Online educational modules, outcomesModule primaryOutcomes measure: Resilience levels of children, primaryOutcomes measure: Resilience levels of parents, secondaryOutcomes measure: Children's emotional and behavioral symptoms, secondaryOutcomes measure: Parenting stress, secondaryOutcomes measure: Parents' psychological distress (i.e., depression, anxiety and stress), secondaryOutcomes measure: Feasibility outcomes - recruitment rate, secondaryOutcomes measure: Feasibility outcomes - retention rate, secondaryOutcomes measure: Feasibility outcomes - attendance, secondaryOutcomes measure: Acceptability of the intervention - level of satisfaction, secondaryOutcomes measure: Acceptability of the intervention, eligibilityModule sex: ALL, minimumAge: 7 Years, maximumAge: 12 Years, stdAges: CHILD, contactsLocationsModule locations facility: The Chinese University of Hong Kong, city: Hong Kong, country: Hong Kong, contacts name: Ankie Tan Cheung, PhD, role: CONTACT, phone: 852 39430515, email: ankiecheung@cuhk.edu.hk, geoPoint lat: 22.27832, lon: 114.17469, hasResults: False
protocolSection identificationModule nctId: NCT06365333, orgStudyIdInfo id: 1451_04/BVNTW-VNCSKTE, briefTitle: Pneumatic Reduction For Intussusception In Children: A Retrospective Cohort Study, statusModule overallStatus: COMPLETED, startDateStruct date: 2016-01, primaryCompletionDateStruct date: 2017-12, completionDateStruct date: 2024-04, studyFirstPostDateStruct date: 2024-04-15, lastUpdatePostDateStruct date: 2024-04-15, sponsorCollaboratorsModule leadSponsor name: National Children's Hospital, Vietnam, class: OTHER, collaborators name: Vinmec Research Institute of Stem Cell and Gene Technology, descriptionModule briefSummary: In pediatric patients, intussusception predominantly occurs in the ileocecal region, with over 90% of cases lacking identifiable causative factors, initiating through peristalsis-driven invagination of bowel segments leading to compromised blood flow and subsequent bowel edema. Persistent obstruction may progress to bowel ischemia and infarction. Vietnam exhibits a higher incidence of intussusception compared to other countries, albeit with similar clinical presentations and anatomical locations, hinting at shared pathophysiology. Despite evidence supporting the safety and efficacy of non-surgical reduction techniques, many medical centers in low- to middle-income countries (LMICs) have not adopted these methods, resulting in unnecessary surgical interventions. The Vietnam National Hospital of Pediatrics (NCH) has employed air enema reduction since the early 2000s but lacks a comprehensive study on fluoroscopic-guided air-enema reduction (FGAR) techniques or success rates. Thus, this study aims to evaluate the long-term outcomes of pneumatic reduction for intussusception at NCH, a high-volume institution in a lower-middle-income country., conditionsModule conditions: Intussusception, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 3562, type: ACTUAL, armsInterventionsModule interventions name: Fluoroscopic-guided air-enema reduction (FGAR), outcomesModule primaryOutcomes measure: Complicated intussusception, primaryOutcomes measure: ICU admission, primaryOutcomes measure: Death, primaryOutcomes measure: Failed FGAR, primaryOutcomes measure: Recurrence, eligibilityModule sex: ALL, minimumAge: 2 Months, maximumAge: 30 Months, stdAges: CHILD, contactsLocationsModule locations facility: The National Hospital of Pediatrics, city: Hanoi, country: Vietnam, geoPoint lat: 21.0245, lon: 105.84117, locations facility: Vinmec Research Institute of Stem Cell and Gene Technology, city: Hanoi, country: Vietnam, geoPoint lat: 21.0245, lon: 105.84117, hasResults: False
protocolSection identificationModule nctId: NCT06365294, orgStudyIdInfo id: REVET Study, briefTitle: Rescue Extracranial Vertebral Stenting in Tandem Occlusions, acronym: REVET, statusModule overallStatus: RECRUITING, startDateStruct date: 2020-12-31, primaryCompletionDateStruct date: 2024-04-30, completionDateStruct date: 2024-05-31, studyFirstPostDateStruct date: 2024-04-15, lastUpdatePostDateStruct date: 2024-04-16, sponsorCollaboratorsModule leadSponsor name: Dr. Cuong Tran Chi, class: OTHER, descriptionModule briefSummary: The acute vertebrobasilar occlusion associated with the poor prognosis, particularly tandem occlusion. However, few data on the efficacy of the endovascular therapy was indicated in this occlusion. The investigators reported whether the additional rescue extracranial stenting improved clinical outcome by modified Rankin Scale (mRS) score within 3 months after the procedure, conditionsModule conditions: Acute Stroke, conditions: Ischemic Stroke, Acute, conditions: Vertebro Basilar Ischemia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 9, type: ESTIMATED, armsInterventionsModule interventions name: Rescue extracranial stenting, outcomesModule primaryOutcomes measure: The good 3-month outcome rate, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 100 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Can Tho SIS Hospital, status: RECRUITING, city: Cần Thơ, zip: 900000, country: Vietnam, contacts name: Cuong Tran Chi, Doctor, role: CONTACT, phone: +84886559911, email: drcuongtran@dotquy.vn, geoPoint lat: 10.03711, lon: 105.78825, hasResults: False
protocolSection identificationModule nctId: NCT06365281, orgStudyIdInfo id: CARIES PREVALENCE, briefTitle: Caries Prevalence, Experience and Risk Related Factors Among Early Middle-aged Patients Attending Cairo University, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2025-05, completionDateStruct date: 2025-08, studyFirstPostDateStruct date: 2024-04-15, lastUpdatePostDateStruct date: 2024-04-15, sponsorCollaboratorsModule leadSponsor name: Cairo University, class: OTHER, descriptionModule briefSummary: Dental caries, a widespread oral health issue, results from a complex interplay of factors including behavior, hygiene, diet, and socio-demographic aspects. While preventive measures are available, it remains prevalent globally, affecting numerous teeth per individual. Improved oral hygiene practices and increased awareness have led to a reduction in caries prevalence. However, rising sugar consumption exceeds dietary guidelines, contributing to the problem. Despite limited epidemiological studies in Egypt, addressing individual-level factors is crucial. Surveillance of oral health in the early middle age group is standard, allowing decision-makers to assess the impact of caries and oral health care provision. Stratifying data by age, geography, and gender aids in understanding prevalence and planning effective prevention strategies. Overall, promoting awareness of dietary habits and preventive practices is vital for improving oral health outcome So, The purpose of this study is to assess the prevalence of dental caries among early middle age patients attending dental hospital in Faculty of Dentistry, Cairo university and to analyze the related risk factors utilizing WHO Oral Health Questionnaire for Adults., conditionsModule conditions: Dental Caries, conditions: Caries,Dental, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 350, type: ESTIMATED, outcomesModule primaryOutcomes measure: Prevalence of dental caries, secondaryOutcomes measure: Caries experience, secondaryOutcomes measure: Caries risk related factors, eligibilityModule sex: ALL, minimumAge: 35 Years, maximumAge: 44 Years, stdAges: ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06365242, orgStudyIdInfo id: DOACS1_2024, briefTitle: Direct Oral Anticoagulants and Management of Blleding Following Dental Extractions. A Prospective Cohort Study., acronym: DOACS_1, statusModule overallStatus: COMPLETED, startDateStruct date: 2020-07-23, primaryCompletionDateStruct date: 2021-07-27, completionDateStruct date: 2022-12-23, studyFirstPostDateStruct date: 2024-04-15, lastUpdatePostDateStruct date: 2024-04-15, sponsorCollaboratorsModule leadSponsor name: University of Pisa, class: OTHER, descriptionModule briefSummary: Evaluation of DOACs treatment on post-extraction bleeding, conditionsModule conditions: Post Operative Hemorrhage, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 49, type: ACTUAL, armsInterventionsModule, outcomesModule primaryOutcomes measure: Peri-operative hemorrhage, primaryOutcomes measure: Post-operative bleeding, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: U.O. Odontostomatologia e Chirurgia del Cavo Orale, city: Pisa, zip: 56126, country: Italy, geoPoint lat: 43.70853, lon: 10.4036, hasResults: False
protocolSection identificationModule nctId: NCT06365229, orgStudyIdInfo id: 2022-P2-336-02, briefTitle: Percutaneous Unilateral Biportal Endoscopy Versus Uniportal Endoscopy for Lumbar Spinal Stenosis: Study Protocol, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2023-01-01, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-04-15, lastUpdatePostDateStruct date: 2024-04-15, sponsorCollaboratorsModule leadSponsor name: Beijing Friendship Hospital, class: OTHER, descriptionModule briefSummary: A prospective study aimed to compare the efficacy and safety of Unilateral biportal endoscopic (UBE) technique and uniportal endoscopic (UE) technique for treating patients with lumbar spinal stenosis (LSS)., conditionsModule conditions: Lumbar Spinal Stenosis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 120, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Oswestry Disability Index (ODI), secondaryOutcomes measure: Magnetic resonance imaging (MRI), secondaryOutcomes measure: Computed tomography (CT) scans, secondaryOutcomes measure: Creatine kinase (CK), secondaryOutcomes measure: Erythrocyte sedimentation rate (ESR), secondaryOutcomes measure: Surgical complication, secondaryOutcomes measure: VAS (visual analogue scale) for leg pain, secondaryOutcomes measure: VAS (visual analogue scale) for lower back pain, secondaryOutcomes measure: Japanese Orthopaedic Association (JOA) score, secondaryOutcomes measure: Modified MacNab criteria, secondaryOutcomes measure: Operation time, secondaryOutcomes measure: Blood loss, secondaryOutcomes measure: Postoperative hospital stays, secondaryOutcomes measure: Age, secondaryOutcomes measure: Gender, secondaryOutcomes measure: Body mass index (BMI), secondaryOutcomes measure: Medical comorbidity, secondaryOutcomes measure: Smoking status, secondaryOutcomes measure: Alcohol status, secondaryOutcomes measure: Symptoms duration, secondaryOutcomes measure: Physical examination finding, secondaryOutcomes measure: Previous spinal surgery, secondaryOutcomes measure: Affected level, secondaryOutcomes measure: Stenosis grade, secondaryOutcomes measure: Physical-component summary score of the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Beijing Friendship Hospital, city: Beijing, state: Beijing, zip: 100050, country: China, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False
protocolSection identificationModule nctId: NCT06365216, orgStudyIdInfo id: AXO-CLI-210c-03, secondaryIdInfos id: 2023-508895-13-00, type: CTIS, briefTitle: ALS Phase II Study of NX210c, acronym: SEALS, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-09-01, primaryCompletionDateStruct date: 2026-02-01, completionDateStruct date: 2026-02-01, studyFirstPostDateStruct date: 2024-04-15, lastUpdatePostDateStruct date: 2024-04-15, sponsorCollaboratorsModule leadSponsor name: Axoltis Pharma, class: INDUSTRY, collaborators name: ACT4ALS network, descriptionModule briefSummary: This study will investigate the efficacy, safety, tolerability and pharmacokinetics (PK) of multiple intravenous infusions of NX210c, at two dose levels, in patients with Amyotrophic lateral sclerosis (ALS)., conditionsModule conditions: Amyotrophic Lateral Sclerosis, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Double-blind, randomized, placebo-controlled, multicentric, phase II study in adult patients with ALS to assess efficacy, safety, tolerability and pharmacokinetics of multiple intravenous infusions of NX210c.Two doses of NX210c (5 mg/kg and 10 mg/Kg) will be investigated, along with a placebo group which will serve as a reference. Patients will be randomized to one of 3 arms in an allocation ratio of 3:3:2.Patients will participate up to approximately 20 weeks: up to 30 days for screening, 26 days of treatment and 3 months of follow-up. Lumbar punctures will assess cerebrospinal fluid (CSF) NfL and other key CSF biomarkers related to ALS and drug mechanism of action. Blood sampling will be drawn for safety, PK and biomarkers testing. Urine will equally be collected for biomarkers. A comprehensive assessment of the disease, including the ALS Functional Rating Scale (ALSFRS-R) will be performed., primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: NX210c, interventions name: Placebo, outcomesModule primaryOutcomes measure: The effect of NX210c on blood neurofilament light chain (NfL) or on a blood and cerebrospinal fluid (CSF) biomarker of BBB integrity., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: CHU de Lyon HCL, city: Bron, zip: 69500, country: France, contacts name: Emilien Bernard, MD, role: CONTACT, phone: 0033 (0)4 72 35 72 18, email: emilien.bernard@chu-lyon.fr, geoPoint lat: 45.73333, lon: 4.91667, hasResults: False
protocolSection identificationModule nctId: NCT06365203, orgStudyIdInfo id: Through knee amputation, briefTitle: Comparative Study of Through Knee Amputation Versus Above Knee Amputation Regarding Infection Rate and Function, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2025-12, completionDateStruct date: 2026-04, studyFirstPostDateStruct date: 2024-04-15, lastUpdatePostDateStruct date: 2024-04-15, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: The aim of this study is to search and compare outcomes of through knee amputation (TKA) and above knee amputation (AKA) in terms of Technique ,wound healing ,infection rate, function and ambulation, conditionsModule conditions: Amputation of Knee, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Through knee amputation, interventions name: Above knee Amputation, outcomesModule primaryOutcomes measure: Wound healing rate, primaryOutcomes measure: Incidence of infection, secondaryOutcomes measure: Function of the limb Rehabilitation Quality of life, secondaryOutcomes measure: Mortality rate, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06365190, orgStudyIdInfo id: AHMU-PD-rTMS, briefTitle: Effects of a Periodic Repetitive Transcranial Magenetic Stimulation in Parkinson Disease, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2020-04-06, primaryCompletionDateStruct date: 2024-07-31, completionDateStruct date: 2024-07-31, studyFirstPostDateStruct date: 2024-04-15, lastUpdatePostDateStruct date: 2024-04-16, sponsorCollaboratorsModule leadSponsor name: Anhui Medical University, class: OTHER, descriptionModule briefSummary: Previous studies have shown that repetitive transcranial magnetic stimulation(rTMS) can improve clinical symptoms of Parkinson's disease(PD). Continuous theta-burst stimulation(cTBS) is a novel rTMS protocol that produces physiological effects b acting on neurons in the brain, which can decrease the excitability of motor system. This study aims to explore the long-term effects of cTBS on improvement of movement symptoms in patients with PD., conditionsModule conditions: Transcranial Magnetic Stimulation, conditions: Parkinson's Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 47, type: ACTUAL, armsInterventionsModule interventions name: transcranial magnetic stimulation, interventions name: Pharmacotherapy（antiparkinsonian drugs）, outcomesModule primaryOutcomes measure: Unified Parkinson's Disease Rating Scale III scores, secondaryOutcomes measure: Hoehn-Yahr(H-Y) stage, secondaryOutcomes measure: Levodopa equivalent dose, eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Cognitive Neuropsychology Lab Anhui Medical University, city: Hefei, state: Anhui, zip: 230022, country: China, geoPoint lat: 31.86389, lon: 117.28083, hasResults: False