protocolSection identificationModule nctId: NCT06279468, orgStudyIdInfo id: I-23PJ2232, briefTitle: Clinical Effectiveness of Intervertebral Disc Release in Treating Lenke 5 Adolescent Idiopathic Scoliosis, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2026-06-01, completionDateStruct date: 2026-06-01, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Peking Union Medical College Hospital, class: OTHER, descriptionModule briefSummary: Adolescent idiopathic scoliosis (AIS) poses challenges in achieving optimal three-dimensional correction. While posterior fusion with pedicle screws has shown success, osteotomy techniques, such as Ponte osteotomy, have further improved outcomes. However, residual vertebral rotation remains a concern, impacting long-term complications. Intervertebral disc release (IDR) presents a potential solution to enhance derotation and reduce fusion levels, particularly in Lenke Type 5 AIS. This prospective randomized controlled trial aims to evaluate the clinical effectiveness of IDR in treating Lenke 5 AIS, comparing it to Ponte osteotomy. The study focuses on axial vertebral rotation correction, coronal curve improvement, blood loss, hospital stay, and adverse events. Participants aged 10-18 with Lenke 5 AIS will undergo either IDR or Ponte osteotomy, randomly assigned. Outcome measures include axial rotation correction rate, radiographic parameters, and clinical assessments. A total of 132 participants will be recruited. The IDR technique, through posterior disc removal, presents a promising approach to optimize derotation in Lenke 5 AIS. While offering potential advantages, challenges like limited working space and bleeding risks require careful consideration. The study's findings aim to provide robust clinical evidence, enhancing treatment strategies for Lenke 5 AIS and offering innovative approaches for AIS as a whole., conditionsModule conditions: Adolescent Idiopathic Scoliosis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 132, type: ESTIMATED, armsInterventionsModule interventions name: intervertebral disc release, interventions name: Ponte osteotomy, outcomesModule primaryOutcomes measure: The correction rate of axial rotation of the apex vertebrae, secondaryOutcomes measure: Lumbar curve, secondaryOutcomes measure: UIV tilt, secondaryOutcomes measure: C7-CSVL, secondaryOutcomes measure: Lumbar lordosis, secondaryOutcomes measure: SVA, secondaryOutcomes measure: Radiographic parameters measured by CT scan: LIV and LIV+1 translation, secondaryOutcomes measure: LIV tilt, secondaryOutcomes measure: The lowest instrumented vertebra disc angle, secondaryOutcomes measure: Age, secondaryOutcomes measure: Gender, secondaryOutcomes measure: Risser grade of the patients at the time of surgery, secondaryOutcomes measure: number of fused spinal levels, secondaryOutcomes measure: length of operation, secondaryOutcomes measure: Scoliosis Research Society-22,SRS-22 score, secondaryOutcomes measure: the MOS item short from health survey, SF-36 score, secondaryOutcomes measure: EuroQol Five Dimensions Questionnaire, EQ-5D score, secondaryOutcomes measure: Perioperative total blood loss, secondaryOutcomes measure: Visible blood loss, secondaryOutcomes measure: Perioperative transfusion amounts, secondaryOutcomes measure: Perioperative transfusion rates, secondaryOutcomes measure: Rate of postoperative infection, secondaryOutcomes measure: The incidence of nerve damage, secondaryOutcomes measure: The incidence of loss of correction, eligibilityModule sex: ALL, minimumAge: 10 Years, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Peking Union Medical College Hospital, status: RECRUITING, city: Beijing, state: Beijing, zip: 100035, country: China, contacts name: Qianyu Zhuang, Professor, role: CONTACT, phone: +86 15200838996, email: baizhuosong@126.com, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False