hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06384469, orgStudyIdInfo id: 98984697615, briefTitle: The Impact of Rhinoplasty Approach and Used Autologous Cartilage Grafts on the Nasal Skin-soft Tissue Envelope Metabolism, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2025-01-02, primaryCompletionDateStruct date: 2026-01-02, completionDateStruct date: 2026-09-01, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: University Hospital "Sestre Milosrdnice", class: OTHER, descriptionModule briefSummary: This is a prospective observation cohort investigation. Patients, that is participants, undergoing primary functional rhinoplasty will be evaluated in terms of measuring capillary blood lactic acid concentration in the nasal skin-soft tissue envelope immediately after the procedure and 7 days after the procedure.The aim of our study is to test whether or not different rhinoplasty approaches and volume of the used autologous cartilage grafts impact the nasal skin-soft tissue metabolism., conditionsModule conditions: Rhinoplasty, conditions: Nasal Skin-soft Tissue Envelope Metabolism, conditions: Lactic Acid, conditions: Autologous Cartilage Grafting, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Difference of capillary blood lactic acid concentration in the nasal skin-soft tissue envelope depending on the rhinoplasty approach, primaryOutcomes measure: Correlation between the used autologous cartilage graft volume and lactic acid concentration in the nasal skin-soft tissue envelope, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06384456, orgStudyIdInfo id: 23-5708, briefTitle: Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation, acronym: TRADR, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-08, primaryCompletionDateStruct date: 2026-06, completionDateStruct date: 2026-09, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: University Health Network, Toronto, class: OTHER, descriptionModule briefSummary: The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people undergoing surgery for a wrist fracture compared to not using topical TXA (placebo)., conditionsModule conditions: Distal Radius Fractures, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 90, type: ESTIMATED, armsInterventionsModule interventions name: Topical TRanexamic Acid, interventions name: Placebo, outcomesModule primaryOutcomes measure: acute post-op pain, secondaryOutcomes measure: opioid use, secondaryOutcomes measure: persistent pain, secondaryOutcomes measure: unscheduled hand-related procedures, secondaryOutcomes measure: Patient reported function, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Toronto Western Hospital, city: Toronto, state: Ontario, country: Canada, contacts name: Ryan Paul, MD, role: CONTACT, email: ryan.paul2@uhn.ca, geoPoint lat: 43.70011, lon: -79.4163, hasResults: False
protocolSection identificationModule nctId: NCT06384443, orgStudyIdInfo id: 01001099646, briefTitle: Proton Pump Inhibitors in Cirrhotic Patients, statusModule overallStatus: COMPLETED, startDateStruct date: 2020-10-01, primaryCompletionDateStruct date: 2024-03-01, completionDateStruct date: 2024-03-01, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: National Liver Institute, Egypt, class: OTHER, descriptionModule briefSummary: Proton pump inhibitors (PPIs) inappropriate use, in patients with cirrhosis, presents a significant clinical challenge. This study evaluates overprescription and misuse of PPIs in cirrhotic patients. The patterns of use of PPIs will be classified into two groups based on adherence to the proven indications: Group A: Inappropriate use of PPI, Group B: Appropriate use of PPI. We will estimate the prevalence of PPI misuse in cirrhotics and correlate it with different factors., conditionsModule conditions: Proton Pump Inhibitor Adverse Reaction, conditions: Liver Cirrhosis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 1000, type: ACTUAL, armsInterventionsModule, outcomesModule primaryOutcomes measure: Inappropriate use of PPIs, primaryOutcomes measure: Predictors for inappropriate use of PPIs, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: National Liver institute - Menoufia University, city: Shibīn Al Kawm, state: Menoufia, zip: 32511, country: Egypt, geoPoint lat: 30.55258, lon: 31.00904, hasResults: False
protocolSection identificationModule nctId: NCT06384430, orgStudyIdInfo id: MuğlaSKU-NKO, briefTitle: Subacromial Impingement Syndrome, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2024-08-31, completionDateStruct date: 2024-09-01, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: Muğla Sıtkı Koçman University, class: OTHER, descriptionModule briefSummary: Subacromial impingement syndrome is a common shoulder pain disorder. In this study, among the patients who applied to the Physical Medicine and Rehabilitation outpatient clinic of Muğla Training and Research Hospital and were diagnosed with subacromial impingement by anamnesis and clinical tests, inclusion criteria (being between 18-70 years of age, positivity for subacromial impingement syndrome in clinical evaluation (Neer's test, Hawkins Kennedy, supraspinatus palpation test)) and exclusion criteria (under 18 years of age, over 70 years of age, rheumatologic disease diagnosis, symptomatic shoulder osteoarthritis, shoulder instability; shoulder pain in active, passive cervical spine movements, previous shoulder surgery, those with adhesive capsulitis findings (\>50% passive range of motion restriction in 2 planes or full-thickness rotator cuff tear detected on ultrasound), those who received physiotherapy or intra-articular injections in the last 3 months, those with type 2 diabetes or hypothyroidism) will be included in the study. Demographic data of the patients will then be recorded. DASH (Disabilities of the Arm, Shoulder and Hand) and Constant Murley scores will be calculated. 4 years of musculoskeletal ultrasound experience will be recorded by a radiologist using ultrasound (Siemens® V8, LA2-14A probe) in modified Crass position (positioning with the palm of the examined side on the posterior iliac wing) by measuring subacromial bursa thickness, supraspinatus tendon thickness, acromiohumeral distance, supraspinatus tendon thickness/acromiohumeral distance ratio. Demographic data of the patients will then be recorded. DASH (Disabilities of the Arm, Shoulder and Hand) and Constant Murley scores will be calculated., conditionsModule conditions: To Show the Relationship Between Ultrasound Parameters and Shoulder Functional Tests, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 70, type: ESTIMATED, armsInterventionsModule interventions name: Shoulder functional tests and ultrasound, outcomesModule primaryOutcomes measure: subacromial bursa thickness, primaryOutcomes measure: supraspinatus tendon thickness, primaryOutcomes measure: acromiohumeral distance, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Mugla Egitim Arastima, status: RECRUITING, city: Mugla, country: Turkey, contacts name: Nihal KARAYER OZGUL, 1, role: CONTACT, geoPoint lat: 37.21807, lon: 28.3665, hasResults: False
protocolSection identificationModule nctId: NCT06384404, orgStudyIdInfo id: 2023-14741, briefTitle: Upfront Surgical Resection for Osteosarcoma, acronym: UFSR for OS, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-25, primaryCompletionDateStruct date: 2027-12-31, completionDateStruct date: 2029-12-31, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: Montefiore Medical Center, class: OTHER, descriptionModule briefSummary: The goal of this pilot study is to learn about patients with newly diagnosed osteosarcoma of an extremity, and whether surgically removing the tumor prior to the administration of any chemotherapy will improve functional outcomes. In order to learn about the patient's experience, the study team will administer questionnaires to the patient and surgeon at various timepoints to assess recovery and the function of the extremity., conditionsModule conditions: Osteosarcoma, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: Questionnaire, outcomesModule primaryOutcomes measure: Change in Health-Related Quality of Life (HRQoL) score from Historical Controls, secondaryOutcomes measure: Event Free Survival, eligibilityModule sex: ALL, minimumAge: 5 Years, maximumAge: 40 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Montefiore Medical Center, status: RECRUITING, city: Bronx, state: New York, zip: 10467, country: United States, contacts name: Rebecca Zylber, role: CONTACT, phone: 718-741-2356, email: rzylber@montefiore.org, contacts name: Alice Lee, M.D., role: PRINCIPAL_INVESTIGATOR, contacts name: David Geller, M.D., role: SUB_INVESTIGATOR, geoPoint lat: 40.84985, lon: -73.86641, hasResults: False
protocolSection identificationModule nctId: NCT06384378, orgStudyIdInfo id: FP00006640, briefTitle: Systemic and Central Inflammation in AD, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-03-17, primaryCompletionDateStruct date: 2025-12-30, completionDateStruct date: 2025-12-30, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: The Methodist Hospital Research Institute, class: OTHER, descriptionModule briefSummary: Inflammation could provide a new focus for therapeutic intervention. In this study, we will measure blood and cerebrospinal fluid (CSF) inflammation biomarkers and compare them to measurements of brain glial activation obtained by positron emission tomography (PET). In addition, we will determine the effect of low-dose interleukin-2 (IL-2) immunotherapy, given over 22 weeks, on these inflammation biomarkers., conditionsModule conditions: Alzheimer Disease, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: 11C-ER176, outcomesModule primaryOutcomes measure: Blood inflammation biomarker levels, primaryOutcomes measure: CSF inflammation biomarker levels, primaryOutcomes measure: Voxel-wise, regional and total brain TSPO VT/fP measured with 11C-ER176 PET, eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 86 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Houston Methodist Research Institute, status: RECRUITING, city: Houston, state: Texas, zip: 77030, country: United States, contacts name: Alireza Faridar, role: CONTACT, phone: 713-441-1150, email: afaridar@houstonmethodist.org, geoPoint lat: 29.76328, lon: -95.36327, hasResults: False
protocolSection identificationModule nctId: NCT06384365, orgStudyIdInfo id: 706014-4, briefTitle: Interaction of Inflammation, Taste Perception and Preferences as a Function of Physical Activity and Body Composition, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-15, primaryCompletionDateStruct date: 2024-09-30, completionDateStruct date: 2025-04-30, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: University of Vienna, class: OTHER, descriptionModule briefSummary: The aim of this study is to investigate whether differences in taste perception and preference behavior can be attributed to inflammatory processes induced by physical activity. The focus will be on sweet taste and the perception of fat. A non-invasive, observational study design will be used., conditionsModule conditions: Taste, Altered, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 66, type: ESTIMATED, armsInterventionsModule interventions name: Physical activity, outcomesModule primaryOutcomes measure: Taste sensitivity, primaryOutcomes measure: Taste preference, primaryOutcomes measure: Body composition, primaryOutcomes measure: Low-grade inflammation, secondaryOutcomes measure: Oxidative Stress, secondaryOutcomes measure: fungiform papillae density, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: Christian Doppler Laboratory for Taste Research, status: RECRUITING, city: Vienna, zip: 1090, country: Austria, contacts name: Barbara Lieder, PhD, role: CONTACT, phone: +431427770611, email: Barbara.Lieder@univie.ac.at, geoPoint lat: 48.20849, lon: 16.37208, hasResults: False
protocolSection identificationModule nctId: NCT06384339, orgStudyIdInfo id: ID-ClimAct-1, briefTitle: ID-ClimAct. Influence of Social Motives of Clients and Staff on the Social Climate of Secure Settings, acronym: ID-ClimAct, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-31, primaryCompletionDateStruct date: 2024-09-20, completionDateStruct date: 2024-10-20, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: University Psychiatric Clinics Basel, class: NETWORK, collaborators name: University of Basel, descriptionModule briefSummary: The social climate in secure settings is an essential element to successful rehabilitation. Previous studies indicate that staff characteristics are a relevant factor contributing to a beneficial social climate. Yet, secure settings form a specific and challenging work environment. Staff members are faced with clients who present a variety of difficult emotional and behavioural problems. Social motives for caring and cooperation can be blocked in a threatening environment, favouring dysfunctional interpersonal dynamics between individuals. This observational study explores the reciprocal influences of social motives between clients and staff on the social climate within secure settings., conditionsModule conditions: Social Environment, conditions: Correctional Institutions, conditions: Rehabilitation of Criminals, conditions: Social Dominance, conditions: Interpersonal Relations, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 200, type: ESTIMATED, armsInterventionsModule interventions name: CSIV, Social motive, interventions name: Interpersonal messages and behavior, interventions name: CCS, Social motive, outcomesModule primaryOutcomes measure: Social Climate Perception, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University Psychiatric Clinics Basel, Clinic for Forensics, city: Basel, state: Basel-Stadt, zip: 4002, country: Switzerland, geoPoint lat: 47.55839, lon: 7.57327, hasResults: False
protocolSection identificationModule nctId: NCT06384326, orgStudyIdInfo id: bagattoni3, briefTitle: Parental Perceptions and Acceptance of Silver Diamine Fluoride in Spain and Italy, acronym: SDF, statusModule overallStatus: COMPLETED, startDateStruct date: 2020-09-01, primaryCompletionDateStruct date: 2023-07-01, completionDateStruct date: 2023-08-01, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: University of Bologna, class: OTHER, descriptionModule briefSummary: Assessing parental aesthetic acceptability of Silver Diamine Fluoride (SDF) staining is crucial for its potential implementation in paediatric dentistry. This study represents the third part of a wider project initially focused on evaluating SDF aesthetic acceptability in Italy, then comparing it between Spanish and Italian parents, conditionsModule conditions: Comparative Study, conditions: Aesthetic Perception, conditions: Acceptability, conditions: SDF, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 501, type: ACTUAL, armsInterventionsModule, outcomesModule primaryOutcomes measure: Comparison of SDF's overall acceptance between Spanish and Italian parents, secondaryOutcomes measure: Comparison of SDF's specific acceptability in different scenarios of child's behavior between Spain and Italy, secondaryOutcomes measure: Parental overall acceptability of SD staining according to demographic background, eligibilityModule sex: ALL, maximumAge: 12 Years, stdAges: CHILD, contactsLocationsModule locations facility: Servizio di Assistenza Odontoiatrica per disabili in età evolutiva e di odontoiatria infantile, city: Bologna, zip: 40125, country: Italy, geoPoint lat: 44.49381, lon: 11.33875, hasResults: False
protocolSection identificationModule nctId: NCT06384313, orgStudyIdInfo id: NL86266.068.24, briefTitle: Butyrate-enriched Triglyceride and Diabetes Prevention, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-07-01, primaryCompletionDateStruct date: 2027-09-01, completionDateStruct date: 2027-09-01, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: Maastricht University Medical Center, class: OTHER, descriptionModule briefSummary: A body of animal studies as well as observational studies in humans demonstrated that butyrate is one SCFA that has pronounced positive effects on body weight control, inflammation, and insulin resistance. Even though the SCFA hexanoate is less researched, it has been shown to be involved in anti-inflammatory processes. Of note, acute human studies showed that fibre-induced metabolic improvements are linked to higher SCFA levels in the systemic circulation. We previously showed that a butyrate/hexanoate-enriched triglyceride oil enhanced systemic butyrate and hexanoate concentrations for a prolonged time. Yet, it remains to be determined whether a chronic increase in circulating butyrate and hexanoate concentrations translate into long-term benefits. We hypothesize that a chronic increase of butyrate/hexanoate in the circulation may improve host metabolism and metabolic health by improving adipose tissue function, reducing systemic lipid overflow and inflammation thereby increasing peripheral insulin sensitivity in individual with overweight/obesity and prediabetes., conditionsModule conditions: Type 2 Diabetes, conditions: PreDiabetes, conditions: Obesity, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 48, type: ESTIMATED, armsInterventionsModule interventions name: butyrate/hexanoate-enriched triglycerides, outcomesModule primaryOutcomes measure: Peripheral insulin sensitivity, secondaryOutcomes measure: hepatic insulin sensitivity, secondaryOutcomes measure: adipose tissue insulin sensitivity, secondaryOutcomes measure: Energy expenditure (indirect calorimetry), secondaryOutcomes measure: Substrate oxidation (indirect calorimetry), secondaryOutcomes measure: circulating SCFA, secondaryOutcomes measure: Faecal SCFA, secondaryOutcomes measure: Faecal microbiota composition, secondaryOutcomes measure: Circulating hormones such as insulin, secondaryOutcomes measure: Circulating metabolites such as glucose, secondaryOutcomes measure: body composition, secondaryOutcomes measure: body weight, secondaryOutcomes measure: Gut permeability, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06384300, orgStudyIdInfo id: BMSF, briefTitle: Financial Incentives and Motivational Intervention to Improve Gastric Cancer Screening in China, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-08-01, primaryCompletionDateStruct date: 2027-01-31, completionDateStruct date: 2027-07-31, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: Peking University, class: OTHER, descriptionModule briefSummary: Gastric cancer, also known as stomach cancer, is a serious disease that affects the stomach. It's one of the most common types of cancer, and sadly, many people die from it each year. But there's hope! We can catch gastric cancer early with a special test called endoscopy. This test helps doctors find cancer or pre-cancerous changes in the stomach early, when it's easier to treat. However, not enough people get this test, especially in places where healthcare isn't easily available. That's why we're doing this study.We want to find out if we can encourage more people to get the endoscopy test for gastric cancer. We're going to try two different ways to encourage people to get the test. First, we'll give some people money or other incentives to help cover the costs of getting the test. Second, we'll give others information and support to help them understand why the test is important and how it can help them.We'll be doing this study in two provinces in China, where gastric cancer is a big problem. We'll ask thousands of people to join the study, and we'll randomly assign them to one of the two groups. Then, we'll see if more people in one group get the endoscopy test compared to the other group.Our hope is that by finding out what works best, we can help more people catch gastric cancer early and get the treatment they need. This could save many lives and make a big difference in fighting this disease., conditionsModule conditions: Gastric Cancer, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: NONE, enrollmentInfo count: 5000, type: ESTIMATED, armsInterventionsModule interventions name: Financial Incentives, interventions name: Motivational Intervention, interventions name: Mixed Intervention, outcomesModule primaryOutcomes measure: Primary Outcome 1, primaryOutcomes measure: Primary Outcome 2, secondaryOutcomes measure: Secondary Outcome, eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False