hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06289075, orgStudyIdInfo id: 23-1096-retro, briefTitle: PrognostICate- Study:Prognostication of ICU- and Ventilator- Days Over the Next Years Until 2040, acronym: PrognostICate, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2024-06-01, completionDateStruct date: 2024-12-01, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-03-01, sponsorCollaboratorsModule leadSponsor name: University Hospital of Cologne, class: OTHER, collaborators name: Johann Wolfgang Goethe University Hospital, collaborators name: Monash University, collaborators name: The Alfred, collaborators name: Albert Einstein College of Medicine, collaborators name: Montefiore Hospital, descriptionModule briefSummary: The Objective of our retrospective multicenter- study is to forecast ICU length of stay (ICULOS) and length of mechanical ventilation (LOMV) in ICU patients of different groups (regarding gender, age group, medical vs surgical admission) worldwide for the next years up to the year of 2040 using statistical forecasting models and historical, national and international ICU databases and population databases., conditionsModule conditions: ICU Admission, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 10000000, type: ESTIMATED, armsInterventionsModule interventions name: Intensive Care Unit (ICU) treatment, outcomesModule primaryOutcomes measure: Length of mechanical ventilation, primaryOutcomes measure: Length of ICU stay, eligibilityModule sex: ALL, minimumAge: 1 Day, maximumAge: 120 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06289049, orgStudyIdInfo id: HREBA.CC-24-0021, briefTitle: Heavy Strength Training in Head and Neck Cancer Survivors, acronym: LIFTING2, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2026-01, completionDateStruct date: 2026-04, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: University of Alberta, class: OTHER, descriptionModule briefSummary: Despite improvements in treatments, head and neck cancer survivors (HNCS) still endure acute and chronic side effects such as loss of muscular strength, limitations in physical functioning, fatigue, and swallowing difficulties that impact quality of life (QoL) and limit return to work. Light-to-moderate intensity strength training (LMST) has been shown to improve some side effects. Heavy lifting strength training (HLST) may further improve outcomes in some populations, however, only one small pilot study has focused on HNCS. The LIFTING 2 trial will be the first to examine the feasibility and effects of a HLST program versus no exercise in HNCS., conditionsModule conditions: Head and Neck Neoplasms, conditions: Head and Neck Cancer, conditions: Head and Neck Squamous Cell Carcinoma, conditions: Head and Neck Carcinoma, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: NONE, maskingDescription: Participants and investigators will not be blinded to group assignment given the nature of the intervention., enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Experimental, outcomesModule primaryOutcomes measure: Recruitment rate, primaryOutcomes measure: Adherence to a heavy lifting strength training program, primaryOutcomes measure: Completion of maximal strength testing, primaryOutcomes measure: Followup assessment rate, primaryOutcomes measure: Safety, secondaryOutcomes measure: Muscular Strength, secondaryOutcomes measure: Cancer Specific Quality of Life, secondaryOutcomes measure: Fear of Cancer Recurrence, secondaryOutcomes measure: Symptom Burden, secondaryOutcomes measure: Perceived Stress, secondaryOutcomes measure: Self-Esteem, secondaryOutcomes measure: Sleep Habits, secondaryOutcomes measure: Malnutrition Status, secondaryOutcomes measure: Swallowing Abilities, secondaryOutcomes measure: Shoulder Range of Motion, secondaryOutcomes measure: Body composition, secondaryOutcomes measure: Handgrip Strength, secondaryOutcomes measure: Physical Function, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Alberta, city: Edmonton, state: Alberta, country: Canada, contacts name: Stephanie Ntoukas, role: CONTACT, email: ntoukas@ualberta.ca, contacts name: Kerry Courneya, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 53.55014, lon: -113.46871, hasResults: False
protocolSection identificationModule nctId: NCT06289036, orgStudyIdInfo id: H2020206632, briefTitle: Prognosis in Subacute Ischemic Stroke Using Multimodal Imaging, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-02-01, primaryCompletionDateStruct date: 2023-12-31, completionDateStruct date: 2023-12-31, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-03-01, sponsorCollaboratorsModule leadSponsor name: The First Hospital of Hebei Medical University, class: OTHER, descriptionModule briefSummary: We enrolled patients with subacute IS, associated with moderate-to-severe stenosis of the unilateral cervical internal carotid artery, who underwent 4D ASL. Perfusion levels and collateral circulation were compared between groups with favorable prognosis (modified Rankin scale \[mRS\] ≤ 2) and poor prognosis (mRS \> 2)., conditionsModule conditions: The Levels of Cerebral Perfusion and Collateral Circulation in Patients With Subacute Stroke, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 28, type: ACTUAL, armsInterventionsModule, outcomesModule primaryOutcomes measure: Modified Rankin Scale（mRS） score after 3 months of onset, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 88 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The First Hospital of Hebei Medical University, city: Shijia Zhuang, state: Hebei, country: China, geoPoint lat: 34.17775, lon: 109.84894, hasResults: False
protocolSection identificationModule nctId: NCT06289023, orgStudyIdInfo id: NCC1278, briefTitle: HA-WBRT-SIB for Brain Metastasis of Lung Cancer, statusModule overallStatus: COMPLETED, startDateStruct date: 2016-01-01, primaryCompletionDateStruct date: 2020-01-01, completionDateStruct date: 2022-12-31, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-03-01, sponsorCollaboratorsModule leadSponsor name: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, class: OTHER, descriptionModule briefSummary: Patients with lung cancer and brain metastases undergo HA-WBRT-SIB using image-guided radiotherapy, receiving a total dose of 30-36 Gy delivered in 18-20 fractions to the whole brain (CTV), while the dose to the GTV is boosted to 44 Gy-52 Gy in 18-20 fractions, ﬁve times a week. The optimal mean dose (Dmean) to the bilateral hippocampus should optimally be ≤ 8 Gy, with a mandatory maximum dose (Dmax) to the hippocampus not exceeding 10 Gy; the preferred Dmean to the hippocampus PRV should optimally be ≤ 9 Gy, while the mandatory Dmax to the hippocampus PRV should be ≤ 12 Gy. The HVLT-R immediate recall scores are obtained at baseline and 1, 3, and 6 months after treatment., conditionsModule conditions: Lung Neoplasm, conditions: Brain Metastases, conditions: Simultaneous Integrated Boost, conditions: Hippocampal Avoidance, conditions: Cognitive Function, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 40, type: ACTUAL, armsInterventionsModule interventions name: HA-WBRT-SIB, outcomesModule primaryOutcomes measure: OS, secondaryOutcomes measure: PFS, secondaryOutcomes measure: iPFS, secondaryOutcomes measure: HVLT-R learning score, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciecnces and Peking Union Medical College, city: Beijing, state: Beijing, country: China, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False
protocolSection identificationModule nctId: NCT06289010, orgStudyIdInfo id: 7354E, briefTitle: Neural Mechanisms of Family-Focused Treatment for Youth Depression, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2027-03, completionDateStruct date: 2027-11, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Boston University Charles River Campus, class: OTHER, collaborators name: Massachusetts Institute of Technology, descriptionModule briefSummary: The goal of this interventional study is to compare the baseline neural mechanisms and parenting in depressed and non-depressed children and to examine baseline neural mechanisms and parenting as predictors of Family-Focused Treatment for Childhood-Depression (FFT-CD) outcomes. The main questions it aims to answer are:* What are differences between depressed and non-depressed participants on baseline neural and parenting indicators?* Do baseline neural and parenting indicators predict response to FFT-CD?* Does change in parenting and neural functioning mediate change in depression from baseline to follow-up?Participants will:* complete baseline clinical measures* complete neuroimaging tasks via Functional Magnetic Resonance Imaging (fMR)* undergo a 12-session course of FFT-CD* complete follow up evaluations and neuroimaging, conditionsModule conditions: Childhood Depression, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Family-Focused Treatment for Childhood-Depression (FFT-CD), outcomesModule primaryOutcomes measure: Depression Treatment Response, primaryOutcomes measure: Children's Self Report of Depressive Symptoms, secondaryOutcomes measure: Depression Remission, eligibilityModule sex: ALL, minimumAge: 7 Years, maximumAge: 12 Years, stdAges: CHILD, contactsLocationsModule locations facility: Boston University, city: Boston, state: Massachusetts, zip: 02215, country: United States, contacts name: Martha C Tompson, PhD, role: CONTACT, phone: 617-358-4584, email: mtompson@bu.edu, contacts name: Natalie Marr, BS, role: CONTACT, phone: 6173539610, email: nmarr@bu.edu, contacts name: Martha C Tompson, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.35843, lon: -71.05977, locations facility: Athinoula A. Martinos Imaging Center at Massachusetts Institute of Technology, city: Charlestown, state: Massachusetts, zip: 02129, country: United States, contacts name: John DE Gabrieli, PhD, role: CONTACT, phone: 617-253-8946, email: gabrieli@mit.edu, contacts name: John DE Gabrieli, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.37787, lon: -71.062, hasResults: False
protocolSection identificationModule nctId: NCT06288997, orgStudyIdInfo id: TFYuan_tACS, briefTitle: tACS Intervention for Methamphetamine Addiction, acronym: tACS for MUD, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-11-21, primaryCompletionDateStruct date: 2023-05-09, completionDateStruct date: 2023-11-09, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-03-01, sponsorCollaboratorsModule leadSponsor name: Shanghai Mental Health Center, class: OTHER, descriptionModule briefSummary: A growing body of evidence suggests a wide range of brain areas are critical for regulating cognitive control over decisions and involving in drug related cue processing. Previous studies have demonstrated that transcranial alternating current stimulation (tACS) over prefrontal cortex reduces craving for meth dependences. In this study, the investigators investigated whether a current level of 15mA with a patented frequency of 77.5Hz tACS intervention of prefrontal cortex cortices in methamphetamine addiction could reduce the subjective craving and improve the cognitive abilities., conditionsModule conditions: Methamphetamine-dependence, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 23, type: ACTUAL, armsInterventionsModule interventions name: transcranial alternating current stimulation, interventions name: sham tACS, outcomesModule primaryOutcomes measure: Changes of Cue-induced craving, secondaryOutcomes measure: Changes of cognition: behavioral inhibition, secondaryOutcomes measure: Changes of cognition: choice under ambiguity, secondaryOutcomes measure: changes of neural mechanism, secondaryOutcomes measure: Changes of depression status, secondaryOutcomes measure: Changes of anxiety status, secondaryOutcomes measure: Changes of sleep status, secondaryOutcomes measure: Changes of impulsivity, secondaryOutcomes measure: event-related potential in passive viewing task, otherOutcomes measure: side effect measurements, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Beijing Tiantanghe Addiction Rehab Center, city: Beijing, state: Beijing, zip: 100054, country: China, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False
protocolSection identificationModule nctId: NCT06288984, orgStudyIdInfo id: NFEC-2024-061, briefTitle: Effects of rTMS on Respiratory Function and Gut Microbiota in Patients With Brain Injury, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2026-06-30, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-03-01, sponsorCollaboratorsModule leadSponsor name: Nanfang Hospital, Southern Medical University, class: OTHER, descriptionModule briefSummary: Impaired respiratory function may occur after brain injury, and will progress to restricted respiratory dysfunction without early intervention. At present, there is a lack of effective treatment options for respiratory dysfunction. Repetitive Transcranial Magnetic Stimulation(rTMS) is a non-invasive, painless and non-invasive neuroregulatory technique. In healthy people, rTMS applied to the respiratory motor cortex induces a contralateral respiratory muscle response. However, whether rTMS can improve respiratory function in patients with brain injury remains unclear. gut microbiota can affect muscle function and mass, and animal experiments have shown that probiotics can increase skeletal muscle mass and grip strength in mice. On the other hand, studies have found that rTMS can improve the nutritional status of patients with vegetative state by regulating the structure of gut microbiota. However, it remains unclear whether rTMS can improve respiratory muscle function in patients with brain injury by regulating gut microbiota. Therefore, the investigators intend to apply rTMS to the respiratory motor cortex to observe whether rTMS can improve respiratory function and reduce the incidence of pneumonia in patients with brain injury, and to observe the role of gut microbiota in this process., conditionsModule conditions: Brain Injuries, conditions: Respiratory Function Impaired, conditions: Gut Microbiota, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 74, type: ESTIMATED, armsInterventionsModule interventions name: active rTMS, interventions name: sham rTMS, outcomesModule primaryOutcomes measure: Diaphragm thickness, primaryOutcomes measure: Thickening fraction, secondaryOutcomes measure: Diaphragm mobility, secondaryOutcomes measure: Surface EMG of diaphragm, secondaryOutcomes measure: Forced vital capacity(FVC), secondaryOutcomes measure: Forced expiratory volume at one second（FEV1）, secondaryOutcomes measure: Peak expiratory flow (PEF), secondaryOutcomes measure: Maximum voluntary ventilation (MVV), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06288945, orgStudyIdInfo id: Dry eye syndrome, briefTitle: Effect of an Educational Program on Health-related Outcomes of Patients With Dry Eye Syndrome, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-01-15, primaryCompletionDateStruct date: 2023-09-14, completionDateStruct date: 2023-09-14, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-03-01, sponsorCollaboratorsModule leadSponsor name: Alexandria University, class: OTHER, descriptionModule briefSummary: Dry eye syndrome (DES) is a widespread ocular disease affecting the general population. It is a complex disorder affecting the surface of the eye, marked by an imbalance in the tear film and ocular symptoms. Therefore this study was done to determine the effect of an educational program on health-related outcomes of patients with DES including the severity of symptoms related to DES and their influence on visual-related functions, conditionsModule conditions: Dry Eye Syndrome, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 60, type: ACTUAL, armsInterventionsModule interventions name: Educational Program, outcomesModule primaryOutcomes measure: ocular irritation symptoms associated with Dry eye syndrome and their effect on functions related to vision, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Faculty of Nursing, Alexandria university, city: Alexandria, country: Egypt, geoPoint lat: 31.21564, lon: 29.95527, hasResults: False
protocolSection identificationModule nctId: NCT06288932, orgStudyIdInfo id: NIBD/IRB-263/08-2023, briefTitle: Outcome Study of Conventional Steroids vs. Steroids Combined With Mycopehnolate in Newly Diagnosed Immune Thrombocytopenia Purpura., statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02, primaryCompletionDateStruct date: 2024-05, completionDateStruct date: 2025-01, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-03-01, sponsorCollaboratorsModule leadSponsor name: National Institute of Blood and Marrow Transplant (NIBMT), Pakistan, class: OTHER_GOV, descriptionModule briefSummary: Immune thrombocytopenia Purpura (ITP) is an autoimmune condition delineated by humoral as well as cell mediated immune response against thrombocyte surface proteins GPIIb/IIIa receptors, affecting primary homeostasis leading to mucocutaneous bleeding.ITP is characterized by platelet count \<100 x 109/L. The conventional line of treatment for newly diagnosed ITP is steroids but significant disadvantages have been associated with long term use and a high risk of relapse when reducing the dose. The addition of MMF to the first line treatment of ITP resulted in substantial response and a lower risk of refractory ITP with decreased financial burden and improved outcome., conditionsModule conditions: Immune Thrombocytopenia Purpura, designModule studyType: INTERVENTIONAL, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: The study will comprise the newly diagnosed patients of Immune thrombocytopenia purpura aged 5-60 year. Patients will be included in this trial, with a 1:1 ratio among the two group patients will be in each group. One group will receive steroids alone and the other will receive steroids and MMF., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 104, type: ESTIMATED, armsInterventionsModule interventions name: Mycophenolate Mofetil (MMF) Treatment, outcomesModule primaryOutcomes measure: Platelet count monitoring, secondaryOutcomes measure: Assessment of Health-Related Quality of Life questionnaire, secondaryOutcomes measure: Incidence of adverse events, eligibilityModule sex: ALL, minimumAge: 5 Years, maximumAge: 60 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: National Institute of Blood Diseases and Bone Marrow Transplantation, status: RECRUITING, city: Karachi, state: Sindh, zip: 75300, country: Pakistan, geoPoint lat: 24.8608, lon: 67.0104, hasResults: False
protocolSection identificationModule nctId: NCT06288919, orgStudyIdInfo id: 2023-IMPLHYGIENE, briefTitle: Erythritol vs Ultrasonic Scaler Prophylaxis Systems on Dental Implants With Crowns Made by Different Materials, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2026-04-01, completionDateStruct date: 2026-04-10, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: University of Pavia, class: OTHER, descriptionModule briefSummary: The aim of the study is to assess which prophylaxis methods is the most suitable for peri-implant hygiene between erythritol and ultrasonic scaler with peek inserts.A randomized clinical trial will be conducted on the patient. Patients will be randomly divided into two groups:* Erythritol group: erythritol with a particle size of \~14 µm will be used for 5 seconds (AIRFLOW® PLUS EMS)* Ultrasonic scaler group: a piezoelectric handpiece with peek inserts (Mini Piezon EMS; PI EMS) will be used.Different subgroups will be defined according to the material of the dental crown of the related implant.The oral hygiene session will be carried out every 6 months (2-years follow-up; 6 sessions), after instruction and motivation of the patient, completion of the clinical chart with the recording of the Probing Depth (evaluation in mm of the peri-implant sulcus taken by a periodontal probe; 4 surfaces of the gingival margin are detected: vestibular, palatal/lingual, mesial, distal), Bleeding on Probing and Plaque Index., conditionsModule conditions: Dental Implant Failed, conditions: Peri-implant Mucositis, conditions: Peri-Implantitis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Erythritol prophylactic powders, interventions name: Ultrasonic scaler with peek inserts, outcomesModule primaryOutcomes measure: Probing Depth (PD), primaryOutcomes measure: Bleeding on Probing (BoP), primaryOutcomes measure: Plaque Index, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Unit of Dental Hygiene - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Paediatrics - University of Pavia, city: Pavia, state: Lombardy, zip: 27100, country: Italy, geoPoint lat: 45.19205, lon: 9.15917, hasResults: False