hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06270654, orgStudyIdInfo id: 2023322-12280, briefTitle: Management of Perioperative Pain Using Erector Spinae Plane Block in Open Microscopic Lumbar Surgery, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-06-01, primaryCompletionDateStruct date: 2024-05-01, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-02-21, sponsorCollaboratorsModule leadSponsor name: University of Malaya, class: OTHER, descriptionModule briefSummary: The aim of this study is to compare patients receiving bilateral erector spinae block with ropivacaine vs control group in terms of pain score, total opioid consumption, hemodynamic changes intraoperatively, length of hospitalisation, time to ambulation post surgery and quality of recovery., conditionsModule conditions: Lumbar Spine Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Erector spinae plane block, interventions name: Skin infiltration LA, outcomesModule primaryOutcomes measure: Pain score at recovery, 30mins, 1, 2, 4, 8,12, 24 hours post-surgery, primaryOutcomes measure: Total opioid consumption intraoperative, primaryOutcomes measure: Total opioid consumption post-operative, primaryOutcomes measure: Timing of first rescue dose of iv morphine, secondaryOutcomes measure: The quality of recovery score (QoR)-15 questionnaire at 24 hours post-operation, secondaryOutcomes measure: Hemodynamic changes intraoperative, secondaryOutcomes measure: Hemodynamic changes intraoperative, secondaryOutcomes measure: Length of hospital stays, secondaryOutcomes measure: Time to ambulation after surgery, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Universiti Malaya Medical Centre, status: RECRUITING, city: Kuala Lumpur, state: Wilayah Persekutuan, zip: 51100, country: Malaysia, contacts name: Wei Keang Tan, M.D., role: CONTACT, phone: +60126655489, email: weikeang@ummc.edu.my, contacts name: Wei Keang Tan, MD., role: PRINCIPAL_INVESTIGATOR, contacts name: Tzi Sen Lee, MBBS, role: SUB_INVESTIGATOR, contacts name: Dharmendra Ganesan, MBBS, FRCS, role: SUB_INVESTIGATOR, geoPoint lat: 3.1412, lon: 101.68653, hasResults: False
protocolSection identificationModule nctId: NCT06270641, orgStudyIdInfo id: STUDY00018628, briefTitle: Increasing Physical Activity for Adults With Multiple Sclerosis (MS), statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-16, primaryCompletionDateStruct date: 2025-04-30, completionDateStruct date: 2026-09-30, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: University of Washington, class: OTHER, descriptionModule briefSummary: This study aims to advance the scientific understanding and potential future implementation of physical activity promotion by testing the efficacy of a phone-based app for increasing activity in insufficiently active patients with multiple sclerosis (MS)., conditionsModule conditions: Multiple Sclerosis (MS), conditions: Fatigue, conditions: Physical Inactivity, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 106, type: ESTIMATED, armsInterventionsModule interventions name: ExerciseRx intervention, outcomesModule primaryOutcomes measure: Physical activity: daily average step count, secondaryOutcomes measure: Activity volume, secondaryOutcomes measure: Minutes/week of moderate intensity aerobic activity, secondaryOutcomes measure: Fatigue - PROMIS Fatigue-MS Short Form 8a, secondaryOutcomes measure: Pain intensity - PROMIS Pain Intensity Short Form 3a, secondaryOutcomes measure: Depressive symptom severity - PROMIS Depression Short Form 8a, secondaryOutcomes measure: Sleep disturbance - PROMIS Sleep Disturbance Short Form 6a, secondaryOutcomes measure: Physical functioning - PROMIS Physical Function 10a, secondaryOutcomes measure: Pain interference - PROMIS Pain Interference Scale Short Form 6a, secondaryOutcomes measure: Social participation - PROMIS Satisfaction with Social Roles and Activities Short Form 8a, secondaryOutcomes measure: Social participation - PROMIS Ability to Participate in Social Roles and Activities Short Form 8a, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: UW Medicine, status: RECRUITING, city: Seattle, state: Washington, zip: 98133, country: United States, contacts name: Laurie Kavanagh, MPH, role: CONTACT, phone: 206-668-4168, email: lauriek@uw.edu, geoPoint lat: 47.60621, lon: -122.33207, hasResults: False
protocolSection identificationModule nctId: NCT06270576, orgStudyIdInfo id: HS3131, briefTitle: Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma, acronym: Nasal-LPS, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2028-04, completionDateStruct date: 2028-06, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-02-21, sponsorCollaboratorsModule leadSponsor name: National Jewish Health, class: OTHER, descriptionModule briefSummary: A phase I clinical research study aimed at determining mechanisms that regulate airway mucosal inflammation in asthma endotypes using intranasal administration of endotoxin (lipopolysaccharide from E. coli) in healthy controls and subjects diagnosed with asthma., conditionsModule conditions: Asthma; Eosinophilic, conditions: Asthma, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Lipopolysaccharides, outcomesModule primaryOutcomes measure: Neutrophil heterogeneity using single cell RNA sequencing, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: National Jewish Health, city: Denver, state: Colorado, zip: 80206, country: United States, contacts name: William J Janssen, MD, role: CONTACT, phone: 303-398-1366, contacts name: Olivia M VerBurg, BA, role: CONTACT, phone: 303-398-1201, contacts name: William J Janssen, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.73915, lon: -104.9847, hasResults: False
protocolSection identificationModule nctId: NCT06270563, orgStudyIdInfo id: P.T.REC/012/003967, briefTitle: High Intensity Laser Therapy Versus Scapular Stabilization Exercises on Ventilatory Function in Forward Head Posture, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-10-01, primaryCompletionDateStruct date: 2023-12-01, completionDateStruct date: 2023-12-01, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-02-21, sponsorCollaboratorsModule leadSponsor name: Cairo University, class: OTHER, descriptionModule briefSummary: The purpose of the study is to compare between the efficacy of high intensity LASER therapy and scapular stabilization exercises on ventilatory functions in forward head posture patients, conditionsModule conditions: Forward Head Posture, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ACTUAL, armsInterventionsModule interventions name: Postural advice, interventions name: Traditional exercise treatment, interventions name: Scapular stabilization exercises, interventions name: High intensity Laser therapy, outcomesModule primaryOutcomes measure: Forced vital capacity (FVC), primaryOutcomes measure: Forced expiratory volume at one second (FEV1), primaryOutcomes measure: FEV1/FVC, primaryOutcomes measure: Maximum voluntary ventilation (MVV), primaryOutcomes measure: Craniovertebral angle (CVA), primaryOutcomes measure: Neck Disability Index (NDI), secondaryOutcomes measure: Upper thoracic chest expansion, secondaryOutcomes measure: Middle thoracic chest expansion, secondaryOutcomes measure: Lower thoracic chest expansion, secondaryOutcomes measure: Visual analogue scale (VAS), eligibilityModule sex: ALL, minimumAge: 30 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule locations facility: Cairo University, city: Giza, country: Egypt, geoPoint lat: 30.00808, lon: 31.21093, hasResults: False
protocolSection identificationModule nctId: NCT06270550, orgStudyIdInfo id: DMI in Spastic Diplegia, briefTitle: Role of Dynamic Movement Intervention in Children With Spastic Diplegia, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2024-11-01, completionDateStruct date: 2024-12-01, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-02-21, sponsorCollaboratorsModule leadSponsor name: Cairo University, class: OTHER, descriptionModule briefSummary: The study aims to investigate the effect of dynamic movement intervention approach on static and dynamic balance, quality of step length and cadence of walking pattern of children with spastic diplegic cerebral palsy., conditionsModule conditions: Spastic Diplegia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Dynamic Movement Intervention, outcomesModule primaryOutcomes measure: Effect of Dynamic movement intervention on balance and quality of walking of the study group compared to control group, measured using Humac Balance System., eligibilityModule sex: ALL, minimumAge: 4 Years, maximumAge: 7 Years, stdAges: CHILD, contactsLocationsModule locations facility: Cairo University, status: RECRUITING, city: Cairo, country: Egypt, geoPoint lat: 30.06263, lon: 31.24967, hasResults: False
protocolSection identificationModule nctId: NCT06270537, orgStudyIdInfo id: Dominus PMCF, briefTitle: Post-market Clinical Trial of the Dominus® Stent-Graft, acronym: DominusPMCF, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-10-24, primaryCompletionDateStruct date: 2025-07-30, completionDateStruct date: 2029-02-28, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-02-21, sponsorCollaboratorsModule leadSponsor name: Braile Biomedica Ind. Com. e Repr. Ltda., class: INDUSTRY, descriptionModule briefSummary: Real-world clinical trial evidence post-market, evaluating the safety and efficacy of the Dominus® StentGraft Endoprosthesis in treating thoracic aortic diseases, following the Instructions for Use, conditionsModule conditions: Thoracic Aortic Dissection, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Stent-Graft Dominus® Endoprosthesis, outcomesModule primaryOutcomes measure: Early occurrence of adverse events (Safety Outcome), secondaryOutcomes measure: Device Success, secondaryOutcomes measure: Absence of endoprosthesis fracture, secondaryOutcomes measure: Endoleak, secondaryOutcomes measure: Reintervention-free, secondaryOutcomes measure: Adverse Events, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hospital Evangélico de Vila Velha, status: NOT_YET_RECRUITING, city: Vila Velha, state: Espirito Santo, zip: 29118-060, country: Brazil, contacts name: Rodrigo Argenta, role: CONTACT, geoPoint lat: -20.32972, lon: -40.2925, locations facility: Hospital Nossa Senhora da Conceição, status: NOT_YET_RECRUITING, city: Porto Alegre, state: Rio Grande Do Sul, zip: 91350-200, country: Brazil, contacts name: Eduardo A Silva, role: CONTACT, geoPoint lat: -30.03306, lon: -51.23, locations facility: Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, status: RECRUITING, city: Ribeirão Preto, state: São Paulo, zip: 14048-900, country: Brazil, contacts name: Ewaldo Joviliano, role: CONTACT, geoPoint lat: -21.1775, lon: -47.81028, hasResults: False
protocolSection identificationModule nctId: NCT06270524, orgStudyIdInfo id: RCAPHM21_0433, briefTitle: Study of the C5a/C5aR1 Axis in IgG4-associated Disease: a Potential Therapeutic Target, acronym: C5-MAG4, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2026-05-01, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-02-21, sponsorCollaboratorsModule leadSponsor name: Assistance Publique Hopitaux De Marseille, class: OTHER, descriptionModule briefSummary: This is a monocentric, comparative, cross-sectional, case-control study seeking to identify abnormalities of the C5a-C5aR1 axis between a population of patients with active IgG4-associated disease (MAG4) and two control groups: healthy subjects without MAG4 and patients with MAG4 in remission., conditionsModule conditions: Immunoglobulin G4-Related Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 66, type: ESTIMATED, armsInterventionsModule interventions name: Blood sampling, outcomesModule primaryOutcomes measure: Serum C5a concentration, secondaryOutcomes measure: frequency of C5aR1+ monocytes among total monocytes, secondaryOutcomes measure: frequency of Tumor Growth Factor B+ (TGF-B+) monocytes among total monocytes, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06270511, orgStudyIdInfo id: 2222T1412, briefTitle: A Study to Investigate Different Formulations of S-337395 in Healthy Adult Participants, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-13, primaryCompletionDateStruct date: 2024-05-31, completionDateStruct date: 2024-06-19, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: Shionogi, class: INDUSTRY, descriptionModule briefSummary: The aim of this study is to investigate different formulations of S-337395., conditionsModule conditions: Healthy Volunteers, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, maskingDescription: Part A will be open label; Part B will be double blind, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: S-337395, interventions name: Placebo, outcomesModule primaryOutcomes measure: Part A: Plasma Concentration of S-337395, primaryOutcomes measure: Part B: Number of Participants Experiencing Treatment-emergent Adverse Events, secondaryOutcomes measure: Part A: Number of Participants Experiencing Treatment-emergent Adverse Events, secondaryOutcomes measure: Part A: Plasma Concentration of S-337395 (Venous Samples Versus Capillary Microsamples), secondaryOutcomes measure: Part B: Plasma Concentration of S-337395, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: ICON Lenexa, status: RECRUITING, city: Lenexa, state: Kansas, zip: 66219, country: United States, geoPoint lat: 38.95362, lon: -94.73357, hasResults: False
protocolSection identificationModule nctId: NCT06270498, orgStudyIdInfo id: 24811, briefTitle: Effect of Oral sucRosomIal Iron on exerciSE Capacity and Quality of Life in Patients With Heart Failure, acronym: RISE-HF, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-03-01, completionDateStruct date: 2025-06-01, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-02-21, sponsorCollaboratorsModule leadSponsor name: Raffaele De Caterina, class: OTHER, collaborators name: University of Pisa, Italy, descriptionModule briefSummary: The goal of this study is to investigate the effect of oral sucrosomial iron on exercise capacity and quality of life in patients with heart failure (HF) and iron deficiency (ID).The main question the study aims to answer is whether oral sucrosomial iron improved exercise capacity, assessed by six-minute walk test, and quality of life, assessed by Kansas City Cardiomyopathy Questionnaire, compared with placebo.One group of participants will receive treatment with oral sucrosomial iron and the other group will receive treatment with placebo., conditionsModule conditions: Chronic Heart Failure, conditions: Iron-deficiency, conditions: Left Ventricular Systolic Dysfunction, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Sucrosomial iron, interventions name: Placebo, outcomesModule primaryOutcomes measure: Exercise capacity, secondaryOutcomes measure: Quality of life, secondaryOutcomes measure: 6MWT distance improvement, secondaryOutcomes measure: Quality of life improvement, secondaryOutcomes measure: Exercise capacity (peak oxygen consumption), secondaryOutcomes measure: F2-isoprostanes, secondaryOutcomes measure: Soluble NOX2-derived peptide (sNOX2-dp), secondaryOutcomes measure: H2O2, secondaryOutcomes measure: Phosphate, secondaryOutcomes measure: Fibroblast growth factor (FGF)-23, otherOutcomes measure: N-terminal pro-B-type natriuretic peptide (NTproBNP), otherOutcomes measure: Transferrin saturation (TSAT), otherOutcomes measure: Ferritin, otherOutcomes measure: Serum iron, otherOutcomes measure: Soluble transferrin receptor (sTfR), otherOutcomes measure: Hepcidin, otherOutcomes measure: Cardiac structure and function 1, otherOutcomes measure: Cardiac structure and function 2, otherOutcomes measure: Cardiac structure and function 3, otherOutcomes measure: Cardiac structure and function 4, otherOutcomes measure: Cardiac structure and function 5, otherOutcomes measure: Cardiac structure and function 6, otherOutcomes measure: Clinical outcome, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06270485, orgStudyIdInfo id: EA2/224/23, briefTitle: Influence of Positive-End-Expiratory-Pressure (PEEP) on Cardiac Output in Mechanically Ventilated Children, acronym: IPCOM, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-27, primaryCompletionDateStruct date: 2024-12, completionDateStruct date: 2025-06, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-02-21, sponsorCollaboratorsModule leadSponsor name: Charite University, Berlin, Germany, class: OTHER, collaborators name: University Medical Center Groningen, descriptionModule briefSummary: Interventional Trial to determine the Effect of different PEEP levels on Cardiac output and right-ventricular function in mechanically ventilated children \< 5 years of age, conditionsModule conditions: Ventilation Therapy; Complications, conditions: Congenital Heart Disease, conditions: Children, Only, conditions: Hemodynamic Instability, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 56, type: ESTIMATED, armsInterventionsModule interventions name: PEEP, outcomesModule primaryOutcomes measure: Cardiac Output, secondaryOutcomes measure: TAPSE (cm), secondaryOutcomes measure: respiratory mechanics, secondaryOutcomes measure: TAPSV (cm/s), secondaryOutcomes measure: Global Strain RV (%/sec), secondaryOutcomes measure: Lung Compliance (ml/Min/kg), secondaryOutcomes measure: Esophageal Pressure (mbar), secondaryOutcomes measure: EIT, eligibilityModule sex: ALL, minimumAge: 1 Day, maximumAge: 5 Years, stdAges: CHILD, contactsLocationsModule locations facility: Deutsches Herzzentrum der Charité, status: RECRUITING, city: Berlin, zip: 13353, country: Germany, contacts name: Jan Clausen, MD, role: CONTACT, phone: 004917620808764, email: jan-christoph.clausen@dhzc-charite.de, contacts name: Michael Emeis, MD, role: SUB_INVESTIGATOR, geoPoint lat: 52.52437, lon: 13.41053, locations facility: UMCG, status: RECRUITING, city: Groningen, country: Netherlands, contacts name: Martin Kneyber, PhD, MD, role: CONTACT, email: m.c.j.kneyber@umcg.nl, contacts name: Richard Hollander, MD, role: CONTACT, email: r.a.hollander@umcg.nl, geoPoint lat: 53.21917, lon: 6.56667, hasResults: False
protocolSection identificationModule nctId: NCT06270472, orgStudyIdInfo id: tipp technique, briefTitle: Transinguinal Periperitoneal Technique in Inguinal Hernioplasty, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-03-01, completionDateStruct date: 2025-04-01, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-02-21, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: evaluation of feasibility and efficacy of trans inguinal periperitoneal technique by using conventional mesh inguinal hernia repair in general surgery department in Assiut university hospitals, conditionsModule conditions: Hernia, Inguinal, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: hernioplasty, outcomesModule primaryOutcomes measure: Recurrence rate of inguinal hernia 2 years follow up ., primaryOutcomes measure: Numerical rating score of pain, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule, hasResults: False