protocolSection identificationModule nctId: NCT06338449, orgStudyIdInfo id: XZMU-2022-ZK068, briefTitle: The Impact of Different Exercise Modes on Bile Acid Levels and Liver Function in Patients With Non-alcoholic Fatty Liver Disease, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-10-13, primaryCompletionDateStruct date: 2022-12-20, completionDateStruct date: 2022-12-31, studyFirstPostDateStruct date: 2024-03-29, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Xuzhou Medical University, class: OTHER, descriptionModule briefSummary: The purpose of this clinical trial is to investigate which exercise regimen is more effective in improving non-alcoholic fatty liver disease (NAFLD) in a young population. The primary questions it aims to answer are:Does aerobic training, resistance training, or a combination of both help improve liver function and glycemic and lipid parameters in NAFLD patients? Which of these three exercise regimens is more effective in improving the aforementioned parameters? Is the improvement in liver function related to bile acid metabolism?Participants will:Engage in physical exercise 4-5 times per week for two consecutive months, following a predefined exercise regimen.Have blood samples collected to test for glucose, lipids, liver function, and other parameters before starting the exercise program and after two months of completing the regimen., conditionsModule conditions: Non-alcoholic Fatty Liver Disease NAFLD, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: The specific exercise plan and grouping are as follows:Participants were randomly (Using an electronic random number generator) divided into four groups: control group (Control), aerobic training group (AT), resistance training group (RT), and combined aerobic and resistance training group (AT + RT), with each group consisting of 10 individuals, totaling 40 participants. All participants were young adults aged between 18 and 21 years old., primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: After the data is obtained, the person analyzing the data will not know the specific grouping and participant information. The groups will be replaced by Group A, B, C, D, and the participants will be indicated by their IDs., whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ACTUAL, armsInterventionsModule interventions name: Aerobic training (AT), interventions name: Resistance training (RT), interventions name: Combined aerobic and resistance training (AT + RT), outcomesModule primaryOutcomes measure: Changes in body weight compared to baseline at 8 weeks, primaryOutcomes measure: Changes in Body Mass Index compared to baseline at 8 weeks, primaryOutcomes measure: Changes in total cholesterol compared to baseline at 8 weeks, primaryOutcomes measure: Changes in triglycerides compared to baseline at 8 weeks, primaryOutcomes measure: Changes in high-density lipoprotein compared to baseline at 8 weeks, primaryOutcomes measure: Changes in low-density lipoprotein compared to baseline at 8 weeks, primaryOutcomes measure: Changes in alanine aminotransferase compared to baseline at 8 weeks, primaryOutcomes measure: Changes in aspartate aminotransferase compared to baseline at 8 weeks, primaryOutcomes measure: Changes in alkaline phosphatase compared to baseline at 8 weeks, primaryOutcomes measure: Changes in gamma-glutamyl transferase compared to baseline at 8 weeks, primaryOutcomes measure: Changes in direct bilirubin compared to baseline at 8 weeks, primaryOutcomes measure: Changes in total bile acids compared to baseline at 8 weeks, primaryOutcomes measure: Changes in adenosine deaminase compared to baseline at 8 weeks, secondaryOutcomes measure: Changes in percentage of body fat compared to baseline at 8 weeks, secondaryOutcomes measure: Changes in waist-to-hip ratio compared to baseline at 8 weeks, secondaryOutcomes measure: Changes in blood glucose compared to baseline at 8 weeks, secondaryOutcomes measure: Changes in the level of insulin compared to baseline at 8 weeks, secondaryOutcomes measure: Changes in albumin compared to baseline at 8 weeks, secondaryOutcomes measure: Changes in C-reactive protein compared to baseline at 8 weeks, otherOutcomes measure: Changes in other subtypes of bile acids compared to baseline at 8 weeks, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 23 Years, stdAges: ADULT, contactsLocationsModule locations facility: Outdoor track and field facility of Xuzhou Medical University, city: Xuzhou, state: Jiangsu, zip: 221000, country: China, geoPoint lat: 34.18045, lon: 117.15707, hasResults: False