protocolSection identificationModule nctId: NCT06287580, orgStudyIdInfo id: STU-2024-0140, briefTitle: Effects of Antihypertensive Drug Treatment on Brain Blood Flow, Cognition, and Regulation of Nervous System in Older Adults With Hypertension., statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-15, primaryCompletionDateStruct date: 2026-01-01, completionDateStruct date: 2027-01-01, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-04-24, sponsorCollaboratorsModule leadSponsor name: University of Texas Southwestern Medical Center, class: OTHER, descriptionModule briefSummary: High blood pressure (BP) is a public health problem worldwide. Nearly three-quarters of older adults (age \~60 years) in the United States have high BP. High BP links to many health problems, like stroke. Drug treatments are typically used in clinics to reduce high BP and the risk of associated health problems. However, these drug treatments may not always benefit brain health. For example, drug treatment may reduce brain blood flow, which may reduce cognitive function in older adults with high BP. Alternatively, reduced brain blood flow may cause high BP due to increased nervous system activity (the so-called "fight or flight response"). Thus, monitoring brain blood flow may help to manage high BP during drug treatment.It is unknown if brain blood flow and its control will be altered by drug treatment in older high BP patients. Therefore, study team will recruit older adults with high BP, who receive either drug treatment or a placebo for 2 weeks and will assess brain blood flow, cognitive function, and nervous system control before and after treatment.Results from this study will provide novel and clinically relevant information on the impact of drug treatment for high BP on brain health. Investigators expect these results will suggest that it is crucial to measure brain blood flow, which may be a therapeutic new target for BP control and brain health., conditionsModule conditions: Essential Hypertension, conditions: Older Adults, designModule studyType: INTERVENTIONAL, phases: EARLY_PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: chlorthalidone 25 mg, interventions name: Placebo, outcomesModule primaryOutcomes measure: Change in Muscle sympathetic nerve activity (MSNA) from baseline at 2 weeks post intervention, primaryOutcomes measure: Change in cognitive performance from baseline at 2 weeks post intervention via Stroop Color and Word Test, primaryOutcomes measure: Change in cognitive performance from baseline at 2 weeks post intervention via NIH Toolbox Cognitive Battery, primaryOutcomes measure: Change in Cerebral blood flow from baseline at 2 weeks post intervention, eligibilityModule sex: ALL, minimumAge: 60 Years, maximumAge: 85 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Institute for Exercise and Environmental Medicine, city: Dallas, state: Texas, zip: 75231, country: United States, contacts name: Takuro Washio, Ph.D., role: CONTACT, phone: 214-345-4852, email: TakuroWashio@texashealth.org, geoPoint lat: 32.78306, lon: -96.80667, hasResults: False