protocolSection identificationModule nctId: NCT06273748, orgStudyIdInfo id: RChildUV, briefTitle: RChildUV:Study on Non-infectious Chronic Uveitis in Pediatric Age, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-02-10, primaryCompletionDateStruct date: 2032-02-01, completionDateStruct date: 2032-05-02, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: Meyer Children's Hospital IRCCS, class: OTHER, descriptionModule briefSummary: Uveitis is an inflammatory disease of the uvea, one of the highly vascularized fundamental structures of the eye. It is a rare condition in children, with an incidence in the pediatric population ranging from 2% to 14% of all uveitis cases. The diagnosis and management of patients with uveitis rely on a multidisciplinary approach involving an ophthalmologist, a rheumatologist, and an infectious disease specialist to establish the correct diagnosis and assess the involvement of other organs. In Italy, there is no national or regional registry for non-infectious chronic uveitis as per the Prime Ministerial Decree (DPCM) of March 3, 2017 (Identification of surveillance systems and registries for mortality, tumors, and other diseases). However, many clinical centers adopt data recording systems to evaluate the quality of care and to study diseases and outcomes. The Universitary Hospital Meyer Institute Research Hospital (IRCCS) is a national referral center for managing these pediatric cases of non-infectious chronic uveitis, estimated to constitute 95% of all pediatric uveitis cases, conditionsModule conditions: Uveitis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 290, type: ESTIMATED, outcomesModule primaryOutcomes measure: Describe a population of paediatric patients with chronic non-infectious uveitis, primaryOutcomes measure: Describe a population of paediatric patients with chronic non-infectious uveitis, primaryOutcomes measure: Identify any differences between the different forms of uveitis in terms of characteristics and outcomes, primaryOutcomes measure: Identify risk factors for a more severe course, primaryOutcomes measure: Frequency achievement of response for each drug according to the definition of response, primaryOutcomes measure: Time to archieve the response after drug initiation, primaryOutcomes measure: Achievement of inactive disease on therapy according to the definition of MIWGUC, primaryOutcomes measure: Time to achieve inactive disease on therapy according to the definition of MIWGUC, primaryOutcomes measure: Presence and percentages of flares on therapy after achievement of remission on therapy, primaryOutcomes measure: Time to the first flare on therapy, primaryOutcomes measure: Time to flare after drug withdrawal, eligibilityModule sex: ALL, minimumAge: 1 Year, maximumAge: 16 Years, stdAges: CHILD, contactsLocationsModule locations facility: Cincinnati Children's Hospital Medical Center, status: RECRUITING, city: Cincinnati, state: Ohio, zip: 45207, country: United States, contacts name: Sheila Angels-Han, role: CONTACT, geoPoint lat: 39.12713, lon: -84.51435, locations facility: - ATTIKON General Hospital, status: RECRUITING, city: Athens, zip: 12462, country: Greece, contacts name: Lampros Fotis, role: CONTACT, geoPoint lat: 37.97945, lon: 23.71622, locations facility: Meyer Children's Hospital IRCCS, status: RECRUITING, city: Florence, state: Firenze, country: Italy, contacts name: Gabriele Simonini, role: CONTACT, email: gabriele.simonini@meyer.it, geoPoint lat: 43.77925, lon: 11.24626, locations facility: Ospedale Spedali Civili di Brescia, status: NOT_YET_RECRUITING, city: Brescia, country: Italy, contacts name: Marco Cattalini, role: CONTACT, geoPoint lat: 45.53558, lon: 10.21472, locations facility: IRCCS materno infantile Burlo Garofolo, status: RECRUITING, city: Trieste, country: Italy, contacts name: Serena Pastore, role: CONTACT, geoPoint lat: 45.64953, lon: 13.77679, hasResults: False