protocolSection identificationModule nctId: NCT06316609, orgStudyIdInfo id: AD2016-2027, briefTitle: Prenatal Exposure to Emerging Contaminants and Children's Atopic Dermatitis, acronym: PECCAD, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2016-06, primaryCompletionDateStruct date: 2018-04-30, completionDateStruct date: 2027-12-31, studyFirstPostDateStruct date: 2024-03-18, lastUpdatePostDateStruct date: 2024-03-18, sponsorCollaboratorsModule leadSponsor name: Children's Hospital of Fudan University, class: OTHER, collaborators name: Minhang Maternal and Children Health Care Hospital, collaborators name: School of Public Health，Fudan University, descriptionModule briefSummary: This prospective cohort study aims to investigate the association between prenatal blood levels of Emerging Contaminants and the five-year incidence of atopic dermatitis (AD) in offspring., conditionsModule conditions: Atopic Dermatitis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 456, type: ACTUAL, armsInterventionsModule interventions name: Gestational Exposure to Emerging Contaminants (ECs), outcomesModule primaryOutcomes measure: atopic dermatitis: Infant atopic dermatitis incidence, secondaryOutcomes measure: atopic dermatitis, secondaryOutcomes measure: atopic dermatitis, secondaryOutcomes measure: atopic dermatitis, secondaryOutcomes measure: prenatal exposure to Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) at early pregnancy, secondaryOutcomes measure: prenatal exposure to Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) at mid pregnancy, secondaryOutcomes measure: prenatal exposure to Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) at late pregnancy, secondaryOutcomes measure: prenatal exposure to Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) at first trimester, secondaryOutcomes measure: prenatal exposure to Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) at second trimester, secondaryOutcomes measure: prenatal exposure to Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) at third trimester, secondaryOutcomes measure: Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) in Umbilical cord whole blood, secondaryOutcomes measure: Umbilical cord serum Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs), secondaryOutcomes measure: prenatal exposure to Organophosphate Flame Retardants (OPFRs) at early pregnancy, secondaryOutcomes measure: prenatal exposure to Organophosphate Flame Retardants (OPFRs) at mid pregnancy, secondaryOutcomes measure: prenatal exposure to Organophosphate Flame Retardants (OPFRs) at late pregnancy, secondaryOutcomes measure: prenatal exposure to Organophosphate Flame Retardants (OPFRs) at first trimester, secondaryOutcomes measure: prenatal exposure to Organophosphate Flame Retardants (OPFRs) at second trimester, secondaryOutcomes measure: prenatal exposure to Organophosphate Flame Retardants (OPFRs) at third trimester, secondaryOutcomes measure: Organophosphate Flame Retardants (OPFRs) in Umbilical cord whole blood, secondaryOutcomes measure: Umbilical cord serum Organophosphate Flame Retardants (OPFRs), secondaryOutcomes measure: Infant skin barrier function (Transepidermal Water Loss, TEWL）, secondaryOutcomes measure: Infant skin barrier function (Transepidermal Water Loss, TEWL）, secondaryOutcomes measure: Infant skin barrier function (Transepidermal Water Loss, TEWL）, secondaryOutcomes measure: Infant skin barrier function (Stratum corneum hydration, SCH), secondaryOutcomes measure: Infant skin barrier function (Stratum corneum hydration, SCH), secondaryOutcomes measure: Infant skin barrier function (Stratum corneum hydration, SCH), secondaryOutcomes measure: Infant skin barrier function (sebum content), secondaryOutcomes measure: Infant skin barrier function (sebum content), secondaryOutcomes measure: Infant skin barrier function (sebum content), secondaryOutcomes measure: Infant skin barrier function (skin surface pH), secondaryOutcomes measure: Infant skin barrier function (skin surface pH), secondaryOutcomes measure: Infant skin barrier function (skin surface pH), secondaryOutcomes measure: prenatal exposure to Microplastics at early pregnancy, secondaryOutcomes measure: prenatal exposure to Microplastics at mid pregnancy, secondaryOutcomes measure: prenatal exposure to Microplastics at late pregnancy, secondaryOutcomes measure: prenatal exposure to Microplastics at first trimester, secondaryOutcomes measure: prenatal exposure to Microplastics at second trimester, secondaryOutcomes measure: prenatal exposure to Microplastics at third trimester, secondaryOutcomes measure: Microplastics in Umbilical cord whole blood, secondaryOutcomes measure: Umbilical cord serum Microplastics, secondaryOutcomes measure: Allergic rhinitis, secondaryOutcomes measure: Asthma, secondaryOutcomes measure: Infantile hemangioma, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Children Hospital of Fudan University, city: Shanghai, state: Shanghai, zip: 201102, country: China, geoPoint lat: 31.22222, lon: 121.45806, hasResults: False