protocolSection identificationModule nctId: NCT06287476, orgStudyIdInfo id: H-23043870, briefTitle: Alveolar-capillary Reserve After Exercise in Chronic Obstructive Pulmonary Disease (COPD) (COP-DTPA), statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-15, primaryCompletionDateStruct date: 2025-03-15, completionDateStruct date: 2025-03-15, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-03-01, sponsorCollaboratorsModule leadSponsor name: Rigshospitalet, Denmark, class: OTHER, descriptionModule briefSummary: It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass., conditionsModule conditions: Chronic Obstructive Pulmonary Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 32, type: ESTIMATED, armsInterventionsModule interventions name: Acute exercise bout on visit 2 and 3, outcomesModule primaryOutcomes measure: Rest-to-exercise pulmonary DTPA clearance change after exercise in COPD vs. controls, secondaryOutcomes measure: Pulmonary DTPA clearance at rest in COPD vs. controls, secondaryOutcomes measure: Pulmonary DTPA clearance after exercise in COPD vs. controls, secondaryOutcomes measure: Rest-to-exercise change in lung tissue mass in COPD vs. controls, otherOutcomes measure: Lung tissue mass at rest in COPD vs. controls, otherOutcomes measure: Lung tissue mass after exercise in COPD vs. controls, otherOutcomes measure: Rest-to-exercise pulmonary DTPA clearance and lung tissue mass change according to GOLD, otherOutcomes measure: Supine pulmonary capillary blood volume after exercise in COPD vs. controls, otherOutcomes measure: Supine cardiac output after exercise in COPD vs. controls, otherOutcomes measure: Supine pulmonary capillary blood volume at rest in COPD vs. controls, otherOutcomes measure: Supine cardiac output at rest in COPD vs. controls, otherOutcomes measure: Supine pulmonary diffusing capacity to nitric oxide (DLNO) after exercise in COPD vs. controls, otherOutcomes measure: Supine haemoglobin-corrected pulmonary diffusing capacity to carbon monoxide (DLCOc) after exercise in COPD vs. controls, otherOutcomes measure: Supine alveolar-capillary membrane diffusing capacity (DM) after exercise in COPD vs. controls, otherOutcomes measure: Supine pulmonary diffusing capacity to nitric oxide (DLNO) at rest in COPD vs. controls, otherOutcomes measure: Supine haemoglobin-corrected pulmonary diffusing capacity to carbon monoxide (DLCOc) at rest in COPD vs. controls, otherOutcomes measure: Supine alveolar-capillary membrane diffusing capacity (DM) at rest in COPD vs. controls, eligibilityModule sex: ALL, minimumAge: 45 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Center For Physical Activity Research, Rigshospitalet, city: Copenhagen, country: Denmark, geoPoint lat: 55.67594, lon: 12.56553, hasResults: False