protocolSection identificationModule nctId: NCT06306287, orgStudyIdInfo id: DA053660, briefTitle: Adolescent Screening and Personalized Intervention Resource for Enhancement of Behavioral Health and Substance Use, acronym: ASPIRE, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-15, primaryCompletionDateStruct date: 2024-11-30, completionDateStruct date: 2025-04-30, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: Oregon Research Institute, class: OTHER, descriptionModule briefSummary: Only a small fraction of youth who are beginning to experience behavioral health problems and use alcohol or illicit drugs receive needed treatment services due to the lack of accessible, effective early intervention resources. The goal of this clinical trial is to compare a personalized brief web-based early intervention, eHealth Personalized Approach for Change Efficacy (ePACE), in which youth are offered choices regarding intervention content and desired level of engagement, to a "fixed", non-tailored brief intervention, eHealth Fixed Approach for Change Efficacy (eFACE) for adolescents with mild/moderate substance use and common co-occurring problems. Both ePACE and eFACE include a multi-problem screener that guides youths through a set of key integrated behavior change and counseling modules providing a cohesive focus on these four problem domains: drug abuse, interpersonal relations, negative emotions and stress. The main questions the trial aims to answer are:* Are substance use and co-occurring problem outcomes for ePACE and eFACE are superior to those for a waitlist comparison group (WC)* Are outcomes for ePACE are superior to those for eFACE* Are the direct effects of ePACE and eFACE (i.e., the improvements in substance use and co-occurring problem outcomes) associated with improvements in areas of functioning and new skills that are hypothesized to produce change -- that is, are the improvements shown in the ePACE and eFACE groups due to the mechanisms by which change is hypothesized to occur Participants in ePACE and eFACE will complete a baseline assessment prior to engaging in the intervention to which they are assigned and will complete post-intervention assessments 3 months and 6 months later. Participants in the WC group will complete three assessments: at baseline, 3-months, and 6-months., conditionsModule conditions: Substance Use, conditions: Mental Health Issue, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Youth (n=120) will be randomly assigned to one of three conditions (40 youths per condition): ePACE, eFACE, or waitlist comparison (WC) condition., primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: The investigators and the assessors will not have access to the conditions to which participants are assigned until all data are collected., whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 120, type: ESTIMATED, armsInterventionsModule interventions name: ePACE Personalized Intervention, interventions name: eFACE Fixed Intervention, outcomesModule primaryOutcomes measure: Adolescent Substance Use from baseline to 3 months, primaryOutcomes measure: Adolescent Substance Use from baseline to 6 months, primaryOutcomes measure: Youth Report of Internalizing Problems from baseline to 3 months, primaryOutcomes measure: Youth Report of Internalizing Problems Change from baseline to 6-months, primaryOutcomes measure: Youth Report of Externalizing Problems from baseline to 3-months, primaryOutcomes measure: Youth Report of Externalizing Problems from baseline to 6-months, primaryOutcomes measure: Parent Report of Internalizing Problems from baseline to 3-months, primaryOutcomes measure: Parent Report Internalizing Problems from baseline to 6-months, primaryOutcomes measure: Parent Report Externalizing Problems from baseline to 3-months, primaryOutcomes measure: Parent Report Externalizing Problems from baseline to 6-months, secondaryOutcomes measure: Problem-Solving Inventory from baseline to 3-months, secondaryOutcomes measure: Problem-Solving Inventory from baseline to 6-months, secondaryOutcomes measure: Child Global Assessment Scale (CGAS) from baseline to 3-months, secondaryOutcomes measure: Child Global Assessment Scale (CGAS) from baseline to 6-months, secondaryOutcomes measure: Peer Encouragement and Influence from baseline to 3 months, secondaryOutcomes measure: Peer Encouragement and Influence from baseline to 6 months, otherOutcomes measure: Emotion Regulation from baseline to 3 months, otherOutcomes measure: Emotion Regulation - baseline to 6 months, otherOutcomes measure: Change in Urine assay - baseline to 3 months, otherOutcomes measure: Change in Urine assay - 3 months to 6 months, eligibilityModule sex: ALL, minimumAge: 12 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Oregon Research Institute, status: RECRUITING, city: Albuquerque, state: New Mexico, zip: 87109, country: United States, contacts name: Holly B Waldron, PhD, role: CONTACT, phone: 541-915-6196, email: hwaldron@ori.org, contacts name: Aleah A Montano, MA, role: CONTACT, phone: 5054538984, phoneExt: Waldron, email: hollybarrettwaldron@gmail.com, contacts name: Holly B Waldron, PhD, role: PRINCIPAL_INVESTIGATOR, contacts name: Ken C Winters, PhD, role: PRINCIPAL_INVESTIGATOR, contacts name: Timothy J Ozechowski, PhD, role: SUB_INVESTIGATOR, contacts name: Hyman Hops, PhD, role: SUB_INVESTIGATOR, geoPoint lat: 35.08449, lon: -106.65114, hasResults: False