protocolSection identificationModule nctId: NCT06269406, orgStudyIdInfo id: SW008, briefTitle: A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults, acronym: ICLID, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-10, primaryCompletionDateStruct date: 2024-07-10, completionDateStruct date: 2024-09-10, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-02-21, sponsorCollaboratorsModule leadSponsor name: S.LAB (SOLOWAYS), class: OTHER, collaborators name: NMSI DENTMASTER, descriptionModule briefSummary: Dental pain, a common issue in stomatology, requires a multifaceted treatment approach. This study explores the efficacy of combining Ibuprofen with curcumin and liquorice root supplements for managing postoperative dental pain. Curcumin, known for its antioxidant and anti-inflammatory properties, along with liquorice root, may enhance pain relief beyond conventional NSAIDs like Ibuprofen. This randomized, double-blind, placebo-controlled trial aims to evaluate the safety and effectiveness of this combination therapy in adults undergoing the removal of impacted third molars. Participants, aged 18-85, were divided into groups receiving different doses of Ibuprofen and curcumin with liquorice root, compared to a control group receiving Ibuprofen and placebo. The primary outcome is the sum of pain intensity differences over 8 hours, with secondary outcomes including total pain relief and the occurrence of any adverse events. The anticipated sample size, considering a 20% dropout rate, is 264 participants, ensuring the study is powered to detect significant differences in pain management efficacy., conditionsModule conditions: Dental Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 264, type: ESTIMATED, armsInterventionsModule interventions name: ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg, interventions name: ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg, interventions name: The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedure, outcomesModule primaryOutcomes measure: Sum of pain intensity differences (SPID), SPID on the visual analog score VAS (points), secondaryOutcomes measure: Total pain relief (TOTPAR) %, secondaryOutcomes measure: Time to pain half pain gone (in minutes), secondaryOutcomes measure: Duration of pain half gone (in minutes), secondaryOutcomes measure: Any adverse events (facial swelling, nausea, vomiting, headache) (%), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 85 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Nmsi Dentmaster, city: Novosibirsk, state: Novosibirsk Region, zip: 630090, country: Russian Federation, contacts name: Gatilova A Tatyana, MD, role: CONTACT, phone: 9529399919, phoneExt: +7, geoPoint lat: 55.0415, lon: 82.9346, hasResults: False