protocolSection identificationModule nctId: NCT06297928, orgStudyIdInfo id: 2023/11238/I, briefTitle: Metabolomics and Bariatric Surgery in Patients With Metabolically Unhealthy Obesity, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2025-06-01, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-03-07, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Parc de Salut Mar, class: OTHER, descriptionModule briefSummary: The goal of this observational study is to investigate metabolic changes in individuals undergoing bariatric surgery, specifically focusing on those with obesity and varying metabolic health statuses. The main questions it aims to answer are:* Can metabolic markers predict the transition from metabolically unhealthy obesity to metabolically healthy obesity after bariatric surgery?* How do metabolic profiles change in individuals with metabolically healthy obesity after bariatric surgery?* What are the metabolic differences between individuals with metabolically healthy and unhealthy obesity before and after bariatric surgery?Participants will undergo routine evaluations and blood tests before and after bariatric surgery. These tests will include assessments of metabolic health markers and sampling of blood plasma for metabolomic analysis. The study will study changes in metabolic profiles between individuals who transition to metabolically healthy obesity and those who remain metabolically unhealthy after surgery., conditionsModule conditions: Bariatric Surgery Candidate, conditions: Obesity, Morbid, conditions: Obesity, Metabolically Benign, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 145, type: ESTIMATED, armsInterventionsModule interventions name: baratric surgery, outcomesModule primaryOutcomes measure: Identification of Metabolic Signatures Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Analysis Predicting Transition from Metabolically Unhealthy Obesity (MUO) to Metabolically Healthy Obesity (MHO) Status, secondaryOutcomes measure: Comparison of Metabolomic Changes Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) between Patients with Persistent Metabolically Unhealthy Obesity (MUO) and Those Transitioning to Metabolically Healthy Obesity (MHO) Status, secondaryOutcomes measure: Comparison of Baseline Metabolomic Profile and Its Evolution Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) after Surgery between Patients with Metabolically Healthy Obesity (MHO) and Metabolically Unhealthy Obesity (MUO), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Hospital del Mar, status: RECRUITING, city: Barcelona, zip: 08003, country: Spain, contacts name: David Benaiges Boix, PhD, role: CONTACT, phone: 0034932483902, email: dbenaiges@psmar.cat, contacts name: David Benaiges, PhD, role: PRINCIPAL_INVESTIGATOR, contacts name: Joan Pedro-Botet, PhD, role: SUB_INVESTIGATOR, contacts name: Albert Goday, PhD, role: SUB_INVESTIGATOR, contacts name: Carme Serra, role: SUB_INVESTIGATOR, contacts name: Elisenda Climent, PhD, role: SUB_INVESTIGATOR, contacts name: Helena Julià, PhD, role: SUB_INVESTIGATOR, contacts name: Miguel Olano, MD, role: SUB_INVESTIGATOR, contacts name: Oscar Pozo, PhD, role: SUB_INVESTIGATOR, geoPoint lat: 41.38879, lon: 2.15899, hasResults: False