protocolSection identificationModule nctId: NCT06377241, orgStudyIdInfo id: 2023-1436, secondaryIdInfos id: A536000, type: OTHER, domain: UW Madison, secondaryIdInfos id: SMPH/OPHTHAL&VIS SCI/GEN, type: OTHER, domain: UW Madison, secondaryIdInfos id: Protocol Version 2/23/2024, type: OTHER, domain: UW Madison, briefTitle: ScentAware and OCT in MCI vs HC, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-15, primaryCompletionDateStruct date: 2024-06, completionDateStruct date: 2024-06, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: University of Wisconsin, Madison, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to learn whether a new smell test works as well as the standard clinical smell test, if there is a link between sense of smell and variations in the retina, and if these results could be used as a way to identify early stages of Alzheimer's disease. The main questions it aims to answer are:* Whether the test is as effective and reliable as the standard test* Whether there is a link between the results of the smell test and the structure of the back of the eyeParticipants will:* complete a short questionnaire* have pictures of the inside of their eyes taken* perform two smell tests, conditionsModule conditions: Alzheimer Disease, Early Onset, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule interventions name: ScentAware, interventions name: UPSIT, outcomesModule primaryOutcomes measure: Compare test scores of ScentAware olfactory test to the scores of the University of Pennsylvania Smell Identification Test (UPSIT) olfactory test in a clinical setting, primaryOutcomes measure: Compare ScentAware test results conducted with support from clinical staff to the test results when ScentAware test was self-administered independently, primaryOutcomes measure: Compare UPSIT test results conducted with support from clinical staff to the test results when ScentAware test was self-administered independently, secondaryOutcomes measure: Compare baseline ScentAware test scores between cohorts, secondaryOutcomes measure: Compare baseline UPSIT test scores between cohorts, secondaryOutcomes measure: Compare baseline ScentAware test scores to the retinal nerve fiber layer (RNFL) thickness, secondaryOutcomes measure: Compare baseline UPSIT test scores to the retinal nerve fiber layer (RNFL) thickness, secondaryOutcomes measure: Compare baseline ScentAware test scores to the ganglion cell layer (GCL) thickness, secondaryOutcomes measure: Compare baseline UPSIT test scores to the ganglion cell layer (GCL) thickness, eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Wisconsin, status: RECRUITING, city: Madison, state: Wisconsin, zip: 53705, country: United States, contacts name: Amy Remm, role: CONTACT, phone: 608-262-3377, email: amy.remm@wisc.edu, geoPoint lat: 43.07305, lon: -89.40123, hasResults: False