protocolSection identificationModule nctId: NCT06388967, orgStudyIdInfo id: 19288/PCDC, briefTitle: Pancreatic Cancer Detection Consortium, acronym: PCDC, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-03-15, primaryCompletionDateStruct date: 2025-11-21, completionDateStruct date: 2025-11-21, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: City of Hope Medical Center, class: OTHER, descriptionModule briefSummary: This study aims to prospective validate an exosome-based miRNA signature for noninvasive and early detection of pancreatic ductal adenocarcinoma., conditionsModule conditions: Pancreatic Cancer, conditions: Pancreatic Carcinoma, conditions: Pancreatic Adenocarcinoma, conditions: Pancreatic Ductal Adenocarcinoma, conditions: Pancreatic Neoplasms, conditions: Pancreatic Cancer Stage I, conditions: Pancreatic Cancer Stage, conditions: Pancreatic Cancer Resectable, conditions: Pancreatic Cancer Stage 0, conditions: Pancreatic Cancer Stage II, conditions: Pancreatic Cancer Stage III, conditions: Pancreatic Cancer, Adult, conditions: Pancreatic Cancer Non-resectable, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 2000, type: ESTIMATED, armsInterventionsModule interventions name: PANcreatic cancer Exosome Early detectiON (PANXEON), outcomesModule primaryOutcomes measure: Sensitivity, secondaryOutcomes measure: Specificity, secondaryOutcomes measure: Accuracy, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Translational Genomics Research Institute, status: RECRUITING, city: Phoenix, state: Arizona, zip: 85004, country: United States, contacts name: Daniel Von Hoff, role: CONTACT, email: dvh@tgen.org, contacts name: Daniel Von Hoff, role: PRINCIPAL_INVESTIGATOR, contacts name: Haiyong Han, role: SUB_INVESTIGATOR, contacts name: Derek Cridebring, role: SUB_INVESTIGATOR, geoPoint lat: 33.44838, lon: -112.07404, locations facility: Honorhealth, status: RECRUITING, city: Scottsdale, state: Arizona, zip: 85258, country: United States, contacts name: Erkut Borazanci, role: CONTACT, email: erkut.borazanci@honorhealth.com, contacts name: Erkut Borazanci, role: SUB_INVESTIGATOR, geoPoint lat: 33.50921, lon: -111.89903, locations facility: City of Hope Medical Center, status: RECRUITING, city: Monrovia, state: California, zip: 91016, country: United States, contacts name: Ajay Goel, PhD, role: CONTACT, phone: 626-218-3452, email: AJGOEL@COH.ORG, contacts name: Ajay Goel, role: PRINCIPAL_INVESTIGATOR, contacts name: Stanley Hamilton, role: SUB_INVESTIGATOR, contacts name: Vincent Chung, role: SUB_INVESTIGATOR, contacts name: Caiming Xu, role: SUB_INVESTIGATOR, contacts name: Alessandro Mannucci, role: SUB_INVESTIGATOR, geoPoint lat: 34.14806, lon: -117.99895, locations facility: Hoag Center, status: RECRUITING, city: Newport Beach, state: California, zip: 92663, country: United States, contacts name: Michael Demeure, role: CONTACT, email: michael.demeure@hoag.org, contacts name: Michael Demeure, role: SUB_INVESTIGATOR, geoPoint lat: 33.61891, lon: -117.92895, locations facility: OSF HealthCare, status: RECRUITING, city: Peoria, state: Illinois, zip: 61637, country: United States, contacts name: Chandler Wilfong, role: CONTACT, email: chandler.d.wilfong@osfhealthcare.org, contacts name: Chandler Wilfong, role: SUB_INVESTIGATOR, geoPoint lat: 40.69365, lon: -89.58899, locations facility: Ochsner Medical Center, status: RECRUITING, city: Jefferson, state: Louisiana, zip: 70121, country: United States, contacts name: John Bolton, role: CONTACT, email: jbolton@ochsner.org, contacts name: John Bolton, role: SUB_INVESTIGATOR, geoPoint lat: 29.96604, lon: -90.15313, locations facility: Atlantic Health System, status: RECRUITING, city: Morristown, state: New Jersey, zip: 07960, country: United States, contacts name: Angela Alistar, role: CONTACT, email: angela.alistar@atlantichealth.org, contacts name: Angela Alistar, role: SUB_INVESTIGATOR, contacts name: Eric Whitman, role: SUB_INVESTIGATOR, geoPoint lat: 40.79677, lon: -74.48154, locations facility: Piedmont Medical Center, status: RECRUITING, city: Rock Hill, state: South Carolina, zip: 29732, country: United States, contacts name: Andrew Page, role: CONTACT, email: Andrew.Page@piedmont.org, contacts name: Andrew Page, role: SUB_INVESTIGATOR, contacts name: Eyal Meiri, role: SUB_INVESTIGATOR, geoPoint lat: 34.92487, lon: -81.02508, locations facility: Medical College of Wisconsin, status: RECRUITING, city: Milwaukee, state: Wisconsin, zip: 53226, country: United States, contacts name: Douglas Evans, role: CONTACT, email: devans@mcw.edu, contacts name: Douglas Evans, role: SUB_INVESTIGATOR, geoPoint lat: 43.0389, lon: -87.90647, locations facility: Nagoya University, status: RECRUITING, city: Nagoya, country: Japan, contacts name: Yasuhiro Kodera, role: CONTACT, email: ykodera@med.nagoya-u.ac.jp, contacts name: Yasuhiro Kodera, role: SUB_INVESTIGATOR, contacts name: Masamichi Hayashi, role: SUB_INVESTIGATOR, geoPoint lat: 35.18147, lon: 136.90641, locations facility: Asan Medical Center, status: RECRUITING, city: Seoul, country: Korea, Republic of, contacts name: Song Cheol Kim, role: CONTACT, email: drksc@amc.seoul.kr, contacts name: Song Cheol Kim, role: SUB_INVESTIGATOR, geoPoint lat: 37.566, lon: 126.9784, hasResults: False