protocolSection identificationModule nctId: NCT06361082, orgStudyIdInfo id: CORPG5N0061, briefTitle: Ultrasonic Backscatter Imaging for ACL Reconstruction and Shoulder Diseases, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2024-10, completionDateStruct date: 2025-10, studyFirstPostDateStruct date: 2024-04-11, lastUpdatePostDateStruct date: 2024-04-11, sponsorCollaboratorsModule leadSponsor name: Chang Gung Memorial Hospital, class: OTHER, descriptionModule briefSummary: This study explores ultrasonic scattering imaging technology in patients undergoing anterior cruciate ligament (ACL) reconstruction and those with shoulder musculoskeletal disorders. Ultrasonography, widely utilized for diagnosing musculoskeletal conditions, faces limitations due to factors like operator experience and equipment settings, often lacking in quantifiable disease metrics. Nakagami imaging, employing the backscattering statistical distribution model, offers a quantitative assessment method that minimizes subjective interpretation by extracting tissue properties through the interaction between ultrasound and tissue microstructure. The Nakagami model effectively describes tissue scattering statistics, enabling the identification and classification of tissue features based on specific scattering conditions.ACL reconstruction is commonly performed, with postoperative complications including joint stiffness and muscle strength decline, associated with changes in muscle quality and volume. Similarly, soft tissue injuries around the shoulder and ankle are prevalent in sports medicine, with ultrasound used to assess the severity of injuries to soft tissues such as the rotator cuff tendons/muscles and surrounding ligaments of the shoulder, as well as the medial and lateral ligament complexes of the ankle. Preliminary findings suggest that Nakagami imaging can differentiate layers within normal tendons, proposing its potential for visualizing and quantifying soft tissue lesions post-ultrasound, aiming for standardized diagnostic criteria.The results of this project could significantly improve the diagnostic efficacy of musculoskeletal ultrasound, facilitating earlier treatment and reducing the socio-economic impacts. Academically, it positions the investigating team as pioneers in the application of ultrasound inverse scattering imaging technology., conditionsModule conditions: ACL Injury, conditions: ACL Reconstruction, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: DIAGNOSTIC, maskingInfo masking: DOUBLE, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: ACL reconstruction, outcomesModule primaryOutcomes measure: MRI of affected limb- Cross sectional area measured in squared cm of quadriceps muscles, primaryOutcomes measure: Ultrasound Nakagami back scattering analysis- Nakagami index, secondaryOutcomes measure: Physical examination of limbs- Angles of Range of Motion of knee, secondaryOutcomes measure: MRI of affected limb- Quality of knee structures documented with descriptions for MR signals, secondaryOutcomes measure: Physical examination of limbs- Laxity of knee ligaments of subjects number with any positive knee physical findings, secondaryOutcomes measure: Ultrasound of affected limb- Cross sectional area measured in squared cm of quadriceps muscles, secondaryOutcomes measure: Ultrasound of affected limb- Quality of knee structures documented with descriptions for echogenicity, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 99 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False