hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06301880, orgStudyIdInfo id: 3200, briefTitle: Effect of Topically-applied Milrinone or Nitroglycerin on Internal Mammary Artery Free Flow, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-01-01, primaryCompletionDateStruct date: 2023-01-31, completionDateStruct date: 2023-01-31, studyFirstPostDateStruct date: 2024-03-08, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: Damascus University, class: OTHER, descriptionModule briefSummary: Forty-six consecutive patients undergoing elective primary coronary artery bypass grafting were enrolled. After the left IMA was harvested, free flow was measured under controlled hemodynamic conditions before any intervention (flow 1) and at a mean of 12.5 minutes after the topical application of one of three agents (milrinone, nitroglycerin or normal saline) on the IMA (flow 2)., conditionsModule conditions: Internal Mammary Artery Syndrome, conditions: Vasodilation, designModule studyType: INTERVENTIONAL, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, maskingDescription: All surgical procedures and measurements were carried out by a single surgeon (MBI) who was blinded to the topical agent which was applied., whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 46, type: ACTUAL, armsInterventionsModule interventions name: The topical application of a vasodilator on the LIMA graft, outcomesModule primaryOutcomes measure: LIMA free flow, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Damascus University Cardiac Surgery Hospital, city: Damascus, country: Syrian Arab Republic, geoPoint lat: 33.5102, lon: 36.29128, hasResults: False
protocolSection identificationModule nctId: NCT06301867, orgStudyIdInfo id: Pro00113877, briefTitle: Preventing Failed Extubations, acronym: PreFIX, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2024-07-31, completionDateStruct date: 2024-08-31, studyFirstPostDateStruct date: 2024-03-08, lastUpdatePostDateStruct date: 2024-03-21, sponsorCollaboratorsModule leadSponsor name: Duke University, class: OTHER, descriptionModule briefSummary: More than 300,00 people in the United States experience acute respiratory failure and require mechanical ventilation every year. Of those that recover and are extubated, the most common reason for reintubation is recurrent respiratory failure. Our study proposes a novel methodology for identifying those patients most at risk for recurrent respiratory failure., conditionsModule conditions: Mechanical Ventilation Complication, conditions: Weaning Failure, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 250, type: ESTIMATED, armsInterventionsModule interventions name: Plateau Pressure, outcomesModule primaryOutcomes measure: Percentage of patients who had a plateau pressure measured prior to extubation as a measure of feasibility, secondaryOutcomes measure: Percentage of patients who were reintubated prior to hospital discharge, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 120 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Duke University Medical Center, status: RECRUITING, city: Durham, state: North Carolina, zip: 27710, country: United States, contacts name: Elias H Pratt, MD, role: CONTACT, email: elias.pratt@duke.edu, geoPoint lat: 35.99403, lon: -78.89862, hasResults: False
protocolSection identificationModule nctId: NCT06301841, orgStudyIdInfo id: 2023-A00903-42, briefTitle: An Antibiotic Protocol Guided by a Multimodal Approach in AECOPD With Pneumonia in Intensive Care, acronym: BPCTréa2, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-15, primaryCompletionDateStruct date: 2026-04-15, completionDateStruct date: 2026-07-15, studyFirstPostDateStruct date: 2024-03-08, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: University Hospital, Caen, class: OTHER, descriptionModule briefSummary: Investigators propose to conduct a multicenter, prospective, randomized, controlled, assessing the interests of an antibiotic protocol guided by the combined use of serum procalcitonin (PCT) and a broad-panel respiratory multiplex PCR (mPCR) to reduce duration of antibiotics exposure in patients with chronic obstructive pulmonary disease (COPD) hospitalized in intensive care unit (ICU) with pneumonia. The primary endpoint is the number of antibiotic-days for the treatment of pneumonia., conditionsModule conditions: To Reduce Duration of Antibiotics Exposure in Patients With COPD Hospitalized in Intensive Care Unit With Pneumonia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 64, type: ESTIMATED, armsInterventionsModule interventions name: experimental, outcomesModule primaryOutcomes measure: Duration of antibiotic therapy, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Medical Intensive Care Unit, CHU Caen, city: Caen, zip: 14000, country: France, geoPoint lat: 49.18585, lon: -0.35912, hasResults: False
protocolSection identificationModule nctId: NCT06301828, orgStudyIdInfo id: KY202401, briefTitle: Endostar Combined With SBRT and Envafolimab in the Treatment of Advanced Gastrointestinal Tumors, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-21, primaryCompletionDateStruct date: 2025-06-21, completionDateStruct date: 2026-02-21, studyFirstPostDateStruct date: 2024-03-08, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: Nanjing First Hospital, Nanjing Medical University, class: OTHER, descriptionModule briefSummary: This is a single-arm, prospective, exploratory clinical study to evaluate the efficacy and safety of endostar combined with stereotactic body radiation therapy (SBRT) and Envafolimab in patients with advanced gastrointestinal cancer after multi-line treatment., conditionsModule conditions: Gastrointestinal Neoplasms, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Gastrointestinal neoplasms, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 16, type: ESTIMATED, armsInterventionsModule interventions name: Envafolimab Injection, interventions name: Endostar, outcomesModule primaryOutcomes measure: DCR, primaryOutcomes measure: ORR, secondaryOutcomes measure: PFS, secondaryOutcomes measure: Incidence of Treatment-Emergent Adverse Events, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Nanjing First Hospital, status: RECRUITING, city: Nanjing, state: Jiangsu, zip: 210006, country: China, contacts name: wei x wei, M.D., role: CONTACT, phone: 52271000, phoneExt: 025, geoPoint lat: 32.06167, lon: 118.77778, hasResults: False
protocolSection identificationModule nctId: NCT06301815, orgStudyIdInfo id: Shaw_Stroke_REC24/YH/0010_2024, briefTitle: Feasibility of Measuring Vertical Perception in Acute Stroke, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2024-10-31, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-03-08, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: University of Winchester, class: OTHER, collaborators name: Hampshire Hospitals NHS Foundation Trust, collaborators name: University Hospitals Dorset NHS Foundation Trust, descriptionModule briefSummary: The goal of this observational study is to establish if it is feasible to identify vertical perception deficits in people with acute stroke. The primary purpose to the study is:• To establish the feasibility of completing the Catherine Bergego Scale, Scale for Contraversive Pushing (SCP) and bucket test in a clinical environment with acute stroke patients to assist with identification of vertical perception loss.Participants will be asked to complete the assessments with a therapist 48 hours after admission. If they are not completed for any reason attempts will be made to complete them at one, two and four weeks after admission. Some participants will have them completed again on discharge. The Catherine Bergego Scale and SCP are observational and will involve a therapist watching the participant undertake daily activities. The bucket test involves a therapist placing a bucket in front of the face of the participant and asking them to identify when a line on the bottom of the bucket is vertical. Acceptabiliy and feasibility will be further investigated using a survey of participants who complete the assessments and through focus groups with the rehabilitation professionals admininstering the assessments.If it is feasible and acceptable to complete these assessments then further research can use them as an acceptable measure of vertical alignment in the clinical setting., conditionsModule conditions: Stroke, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Scale for Contraversive Pushing, interventions name: Catherine Bergego Scale, interventions name: Bucket Test, outcomesModule primaryOutcomes measure: Bucket Test to measure subjective visual vertical (SVV)., primaryOutcomes measure: Catherine Bergego Scale to measure neglect., primaryOutcomes measure: Scale for Contraversive Pushing to measure lateropulsion, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Royal Hampshire County Hospital, city: Winchester, zip: SO22 5DG, country: United Kingdom, contacts name: Amelia Shaw, MSc, role: CONTACT, phone: 01962 824940, email: amelia.shaw@hhft.nhs.uk, geoPoint lat: 51.06513, lon: -1.3187, hasResults: False
protocolSection identificationModule nctId: NCT06301802, orgStudyIdInfo id: myelomeningocele management, briefTitle: Outcomes of Proactive Management of Children With Myelomeningocele, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-04, primaryCompletionDateStruct date: 2026-03-10, completionDateStruct date: 2026-03-15, studyFirstPostDateStruct date: 2024-03-08, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: Spina bifida birth prevalence in Africa is 0.13%. Myelomeningocele (MMC) represents the most frequent and most severe cause of NB in children. Treatment of neuropathic bladder secondary to spina bifida is an ongoing challenge. Damage of the renal parenchyma in children with NB is preventable given adequate evaluation, follow-up and proactive management. Proactive management was defined as use of clean intermittent catheterization (CIC), and/or anticholinergics at presentation, or based on initial high-risk urodynamic findings by 1 year of age. The proactive approach to treat SB (CIC and pharmacotherapy) has contributed to decreasing chronic kidney disease (CKD). Myelomeningocele is considered a complex congenital disease. Hence, a multidisciplinary team is the best choice for management of spina bifida, involving neurosurgeons, orthopedic surgeons, urologists, physical medicine and rehabilitation specialists and pediatricians. Currently, children with spina bifida in Egypt must visit multiple different locations to access the complex care they need. Here, we review our experience with patients with spina bifida who will be followed with this team with an emphasis on patients' upper urinary tract protection and decreasing urinary incontinence., conditionsModule conditions: Urologic Diseases, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: PROSPECTIVE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: CIC, interventions name: Anticholinergic, outcomesModule primaryOutcomes measure: upper tract affection, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Assiut university hospital, status: RECRUITING, city: Assiut, zip: 11571, country: Egypt, contacts name: Islam Mahmoud, DR, role: CONTACT, phone: 00201090088672, email: doctorislam672@gmail.com, geoPoint lat: 27.18096, lon: 31.18368, hasResults: False
protocolSection identificationModule nctId: NCT06301789, orgStudyIdInfo id: Quadratus lumborum block, briefTitle: Role of Magnesium Sulphate as an Adjuvant to Bupivacaine in U.S Guided Quadratus Lumborum Block in Lower Abdominal Cancer Surgeries, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2026-02, completionDateStruct date: 2026-03, studyFirstPostDateStruct date: 2024-03-08, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: The aim of this study is to assess the efficacy of Mg sulfate ( 10% ) as an adjuvant to Bupivacain ( 0.25 % ) in an U.S guided QLB for postoperative analgesia and postoperative Morphine consumption in lower abdominal cancer surgeries., conditionsModule conditions: QLB in Lower Abdominal Cancer Surgeries as a Post Operative Analgesia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Effect of adding Mg sulphate as an adjuvant to bupivacaine for postoperative analgesia in cases of lower abdominal cancer surgeries, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 52, type: ESTIMATED, armsInterventionsModule interventions name: Effect of adding Mg sulfate as an adjuvant to bupivacain in U/S guided QLB for postoperative analgesia in lower abdominal cancer surgeries, outcomesModule primaryOutcomes measure: Postoperative analgesia, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06301776, orgStudyIdInfo id: Bridge-2023-02-0A, briefTitle: A Prospective, Experimental, Multicenter, Open-label, Randomized, Controlled Trial of 3-month Dual Antiplatelet Therapy Followed by Ticagrelor Versus 6-month Dual Antiplatelet Therapy Followed by Ticagrelor After Implanting Bridge, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-05, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2026-06-30, studyFirstPostDateStruct date: 2024-03-08, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: The Fourth Affiliated Hospital of China Medical University, class: OTHER, descriptionModule briefSummary: To compare the incidence of the composite endpoints of non-fatal ischaemic stroke, transient ischaemia (TIA) and all-cause mortality at 12-month follow-up after implantation of Bridge for the treatment of symptomatic vertebral artery stenosis in subjects who had been taking different durations of dual-antiplatelet therapy (3 vs 6 months) and ticagrelor monotherapy., conditionsModule conditions: Brain Disease, conditions: Vertebral Artery Stenosis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 560, type: ESTIMATED, armsInterventionsModule interventions name: Ticagrelor, outcomesModule primaryOutcomes measure: Incidence of the composite endpoint of non-fatal ischaemic Stroke, TIA, and all-cause mortality at 12-months., secondaryOutcomes measure: Incidence of the composite endpoint of major bleeding and hemorrhagic stroke at 12-months., secondaryOutcomes measure: Incidence of target vessel-related stroke and neurological death at 1month, secondaryOutcomes measure: Incidence of stroke and neurological death at 12 month., secondaryOutcomes measure: Incidence of all-cause mortality at 12 month., secondaryOutcomes measure: Incidence of in-stent-stenosis at 12 month (subgroup of imaging follow-up)., eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: the Fourth Affiliated Hospital of China Medical University, status: RECRUITING, city: Shenyang, state: Liaoning, zip: 110032, country: China, contacts name: Lianbo Gao, role: CONTACT, email: gaolbdoc@163.com, geoPoint lat: 41.79222, lon: 123.43278, hasResults: False
protocolSection identificationModule nctId: NCT06301763, orgStudyIdInfo id: nosencekCancer-old, briefTitle: Oral Enteral Nutrition in Delayed Onset Radiotherapy-related Swallowing Disorder in Nasopharyngeal Carcinoma, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-06-01, primaryCompletionDateStruct date: 2022-12-25, completionDateStruct date: 2022-12-31, studyFirstPostDateStruct date: 2024-03-08, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: Muhammad, class: OTHER, descriptionModule briefSummary: This is a prospective multicenter study with patients with delayed dysphagia after radiotherapy for NPC. Patients enrolled are randomly divided equally into the observation group and the control group. All patients receive conventional care, and the observation group received IOE while the control group received NGT for enteral nutrition support. Baseline information (demographics, medical history, etc.), nutritional status at admission and after treatment, depression, dysphagia, and quality of life (QOL) after treatment as well as adverse events are compared., conditionsModule conditions: Dysphagia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 56, type: ACTUAL, armsInterventionsModule interventions name: Intermittent Oral-esophageal Tube Feeding, interventions name: nasogastric tube feeding, outcomesModule primaryOutcomes measure: Hemoglobin Level, primaryOutcomes measure: Serum albumin Level, primaryOutcomes measure: Total serum protein Level, primaryOutcomes measure: Serum prealbumin Level, primaryOutcomes measure: Body Mass Index Level, secondaryOutcomes measure: Depression, secondaryOutcomes measure: Swallowing-Quality of Life questionnaire, secondaryOutcomes measure: Functional Oral Intake Scale, secondaryOutcomes measure: Penetration-Aspiration Scale, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Ubonratchathani Hospital, city: Ubon Ratchathani, country: Thailand, geoPoint lat: 15.23844, lon: 104.84866, hasResults: False
protocolSection identificationModule nctId: NCT06301750, orgStudyIdInfo id: Tube-Alzheimer, briefTitle: Oral Enteral Nutrition Feeding in Alzheimer's Patients, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2024-06, completionDateStruct date: 2024-06, studyFirstPostDateStruct date: 2024-03-08, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: Muhammad, class: OTHER, descriptionModule briefSummary: This is a prospective multicenter study with Alzheimer's patients with dysphagia. Patients enrolled are randomly divided equally into the observation group and the control group. All patients receive conventional care, and the observation group received Intermittent Oral-esophageal Tube Feeding while the control group received Nasogastric Tube Feeding for enteral nutrition support. Baseline information (demographics, medical history, etc.), nutritional status at admission and after treatment, depression, dysphagia, and quality of life after treatment are compared., conditionsModule conditions: Alzheimer Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Conventional Care, interventions name: Intermittent Oral-esophageal Tube Feeding, interventions name: Nasogastric tube, outcomesModule primaryOutcomes measure: Level of Hemoglobin, primaryOutcomes measure: Level of Serum albumin, primaryOutcomes measure: Level of Total serum protein, primaryOutcomes measure: Level of Serum prealbumin, secondaryOutcomes measure: Body Mass Index, secondaryOutcomes measure: Pulmonary Infections, secondaryOutcomes measure: Mini Nutritional Assessment, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 85 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06301737, orgStudyIdInfo id: SGB-YanD, briefTitle: Lidocaine Injection: A Nove Block Therapy for Stroke-related Dysphagia, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-06-21, primaryCompletionDateStruct date: 2023-05-02, completionDateStruct date: 2023-05-17, studyFirstPostDateStruct date: 2024-03-08, lastUpdatePostDateStruct date: 2024-03-25, sponsorCollaboratorsModule leadSponsor name: Muhammad, class: OTHER, descriptionModule briefSummary: This was a multicenter randomized controlled study. 66 post-stroke patients with pharyngeal dysphagia were randomly allocated to the observation group (n=33) or the control group (n=33). Both groups were provided with comprehensive rehabilitation including routine rehabilitation and swallowing function training. Besides, the observation group additionally underwent the stellate ganglion block (SGB). At admission and after 20-day treatment, Kubota water swallowing test, video fluoroscopic swallowing study (VFSS), and Rosenbek penetration-aspiration scale (PAS) were used to assess swallowing function., conditionsModule conditions: Dysphagia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 65, type: ACTUAL, armsInterventionsModule interventions name: Comprehensive rehabilitation, interventions name: Injection, interventions name: Lidocaine Hydrochloride, outcomesModule primaryOutcomes measure: Video fluoroscopic swallowing study, secondaryOutcomes measure: Rosenbek penetration-aspiration scale, secondaryOutcomes measure: Functional Oral Intake Scale, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Zhen No.1 Hos., city: Taiwan, country: China, geoPoint lat: 32.32812, lon: 118.76384, hasResults: False