protocolSection identificationModule nctId: NCT06264427, orgStudyIdInfo id: KVUG - 2022 - 10, briefTitle: Phenotypic and Genotypic Characterization of Patients With Dysmetabolism in Greenland, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-07-15, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-02-20, sponsorCollaboratorsModule leadSponsor name: Steno Diabetes Center Greenland, class: OTHER, collaborators name: Zealand University Hospital, collaborators name: University of Copenhagen, descriptionModule briefSummary: The goal of this clinical trial is to perform a detailed description of the feno- and genotype of people living with type 2 diabetes and severe obesity who are linked to care at Steno Diabetes Center Greenland.The main questions it aims to answer are:* Are monogenetic diabetes variants associated with the same risk of developing late diabetic complications as other types of diabetes?* Can genotyping and thereby personalized medicine be implemented in Greenland, and can personalized medicine lead to improved treatment?* What is the prevalence of sleep apnea among high-risk individuals in Greenland?* Is it possible to develop and implement a simple algorithm for the identification of sleep apnea in Greenland that can ensure treatment of severe sleep apnea?Participants will:* Answer WHO-5 and FOSQ-10 questionnaires regarding quality of life and functional outcomes of sleepiness* Perform VAGUS examinations for Cardiovasculare Autonomic Neuropathy* Clinical examination of height, weight, circumference of hip, waist and neck, Friedman tonsil and tongue score, nasal air flow, nasal septal deviation* Blood samples for full genome sequencing, conditionsModule conditions: Diabetes Mellitus, Type 2, conditions: Obesity, Morbid, conditions: Obstructive Sleep Apnea, conditions: MODY, conditions: Diabetic Retinopathy, conditions: Diabetic Neuropathies, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Participants will be examined with whole genom sequencing, and diabetes treatment will be accommodated their diabetic fenotype.'For the intervention, participants will be screened for obstructive sleep apnea (OSA). Participants with signs of OSA will be offered treatment with Continuos Positive Airway Pressure., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 1000, type: ESTIMATED, armsInterventionsModule interventions name: Whole genome sequencing, interventions name: VAGUS, interventions name: NightOwl, interventions name: CPAP, outcomesModule primaryOutcomes measure: Number of participants with MODY diabetes and their complication status, primaryOutcomes measure: Number of participants with diabetic complication, primaryOutcomes measure: Number of participants with obstructive sleep apnea, secondaryOutcomes measure: CPAP compliance in Greenlandic patients, secondaryOutcomes measure: CPAP treatment effect on quality of life measured with the World Health Organization Well-being Index (WHO-5)., secondaryOutcomes measure: CPAP treatment effect on daytime sleepiness measured with the functional outcome of sleep questionnaire (FOSQ-10)., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Steno Diabetes Center Greenland, Queen Ingrids Hospital, status: RECRUITING, city: Nuuk, state: Sermersooq, zip: 3900, country: Greenland, contacts name: Mads Mose Jensen, MD., role: CONTACT, phone: +299 34 46 23, email: MMSN@peqqik.gl, contacts name: Marit Eika Jørgensen, Md. Ph.d, role: CONTACT, phone: 34 43 24, email: MAEJ@peqqik.gl, geoPoint lat: 64.18347, lon: -51.72157, hasResults: False