protocolSection identificationModule nctId: NCT06295692, orgStudyIdInfo id: 77242113PSO3005, secondaryIdInfos id: 77242113PSO3005, type: OTHER, domain: Janssen Pharmaceutical K.K., briefTitle: A Study of JNJ-77242113 for the Treatment of Participants With Generalized Pustular Psoriasis or Erythrodermic Psoriasis, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-09, primaryCompletionDateStruct date: 2025-02-19, completionDateStruct date: 2027-12-23, studyFirstPostDateStruct date: 2024-03-06, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: Janssen Pharmaceutical K.K., class: INDUSTRY, descriptionModule briefSummary: The purpose of this study is to evaluate how effective JNJ-77242113 is in participants with generalized pustular psoriasis (GPP) or erythrodermic psoriasis (EP)., conditionsModule conditions: Generalized Pustular Psoriasis, conditions: Erythrodermic Psoriasis, designModule studyType: INTERVENTIONAL, phases: PHASE3, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 16, type: ESTIMATED, armsInterventionsModule interventions name: JNJ-77242113, outcomesModule primaryOutcomes measure: Percentage of Participants With Generalized Pustular Psoriasis (GPP) who Experience Treatment Success Based on Clinical Global Impression (CGI) Scale According to Japanese Dermatological Association (JDA) Total Score at Week 16, primaryOutcomes measure: Percentage of Participants With Erythrodermic Psoriasis (EP) who Experience Treatment Success Based on CGI Scale at Week 16, secondaryOutcomes measure: Percentage of Participants With GPP who Experience Treatment Success Based on CGI Scale According to JDA Total Score Over Time, secondaryOutcomes measure: Percentage of Participants With EP who Experience Treatment Success Based on CGI Scale Over Time, secondaryOutcomes measure: Change From Baseline in Total Score of JDA Severity Index for GPP, secondaryOutcomes measure: Change From Baseline in Severity Classification of JDA Severity Index for GPP, secondaryOutcomes measure: Change From Baseline in Body Surface Area (BSA) for EP, secondaryOutcomes measure: Percentage of Participants who Achieved an Investigator's Global Assessment (IGA) Score of Cleared (0) or Minimal (1), secondaryOutcomes measure: Percentage of Participants who Achieve an IGA Score of Cleared (0), secondaryOutcomes measure: Percent Improvement From Baseline in Psoriasis Area and Severity Index (PASI), secondaryOutcomes measure: Change From Baseline in Dermatology Life Quality Index (DLQI) Score, secondaryOutcomes measure: Percentage of Participants who Achieve a DLQI Score of 0 or 1, secondaryOutcomes measure: Change From Baseline in EuroQol-5 Dimension 5-Level (EQ-5D-5L), secondaryOutcomes measure: Percentage of Participants With Adverse Events (AEs) and Serious AEs, eligibilityModule sex: ALL, minimumAge: 12 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: JR Sapporo Hospital, status: RECRUITING, city: Hokkaido, zip: 060-0033, country: Japan, geoPoint lat: 43.41104, lon: 142.88878, locations facility: Ichinomiya Municipal Hospital, status: RECRUITING, city: Ichinomiya, zip: 491-8558, country: Japan, geoPoint lat: 35.3, lon: 136.8, locations facility: Teikyo University Hospital, status: RECRUITING, city: Itabashi Ku, zip: 173 8606, country: Japan, geoPoint lat: 35.74893, lon: 139.71497, locations facility: Hospital of the University of Occupational and Environmental Health, status: RECRUITING, city: Kitakyushu-shi, zip: 807-8556, country: Japan, geoPoint lat: 33.85181, lon: 130.85034, locations facility: Kumamoto University Hospital, status: RECRUITING, city: Kumamoto, zip: 860-8556, country: Japan, geoPoint lat: 32.80589, lon: 130.69182, locations facility: Nagoya City University Hospital, status: RECRUITING, city: Nagoya, zip: 467 8602, country: Japan, geoPoint lat: 35.18147, lon: 136.90641, locations facility: Public Interest Incorporated Foundation Nipoon Life Saiseikai Nippon Life Hospital, status: RECRUITING, city: Osaka, zip: 550 0006, country: Japan, geoPoint lat: 34.69374, lon: 135.50218, locations facility: Tohoku University Hospital, status: RECRUITING, city: Sendai, zip: 980-8574, country: Japan, geoPoint lat: 38.26667, lon: 140.86667, locations facility: Dokkyo Medical University Hospital, status: RECRUITING, city: Shimotsuga Gun, zip: 321-0293, country: Japan, locations facility: Tokyo Medical University Hospital, status: RECRUITING, city: Shinjuku, zip: 160-0023, country: Japan, geoPoint lat: 35.2946, lon: 139.57059, locations facility: Fujita Health University Hospital, status: RECRUITING, city: Toyoake, zip: 470-1192, country: Japan, geoPoint lat: 35.038, lon: 136.99931, locations facility: Mie University Hospital, status: RECRUITING, city: Tsu, zip: 514 8507, country: Japan, geoPoint lat: 34.73333, lon: 136.51667, hasResults: False