protocolSection identificationModule nctId: NCT06329804, orgStudyIdInfo id: RM_01-11-21b, briefTitle: The Dose Response Effect of Isometric Handgrip Training Frequency on Blood Pressure in Normotensive Individuals, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-11-01, primaryCompletionDateStruct date: 2024-05-31, completionDateStruct date: 2024-05-31, studyFirstPostDateStruct date: 2024-03-26, lastUpdatePostDateStruct date: 2024-03-26, sponsorCollaboratorsModule leadSponsor name: Swansea University, class: OTHER, collaborators name: National Taiwan Normal University, descriptionModule briefSummary: It is estimated by WHO (2021) that 1.4 billion individuals across the globe have high blood pressure with only 14% of people managing these elevated levels. Simple and effective lifestyle strategies are required to help people improve their blood pressure and/or attenuate increases in blood pressure with ageing. Exercise is one possible strategy: in previous research, several different types of exercise have been shown to have effects on blood pressure (Blackwell et al., 2017). However, many individuals do not adhere to currently recommended levels of exercise (150 mins of moderate intensity exercise per week), due to a combination of the required time commitment, lack of motivation, and the associated levels of effort / exertion and discomfort (Korkiakangas et al 2009). Thus, there is a need to investigate alternative exercise interventions which will overcome these barriers but remain effective at improving blood pressure (Herrod, Lund, \& Phillips, 2021).Low intensity isometric hand grip training (IHGT) has been shown to result in large decreases in rest-ing blood pressure in younger and older age groups, in both men and women, and in individuals with normal as well as elevated baseline blood pressure (Badrov et al, 2013; Bentley et al., 2018; Millar et al., 2014). In this research, IHGT has typically involved performing 4 x 2 IHGT holds at 30% of maximal voluntary contraction, 3 times a week, over a 4-8-week intervention (Millar et al, 2014). Interestingly, there are very few studies that have investigated the effect of changing different protocol parameters on the adaptations in blood pressure, and the minimal effective dose of IHGT is unknown. One important modifiable parameter is training frequency and it is unknown whether reducing the frequency of IHGT will reduce the efficacy for improving blood pressure. Therefore, the aim of this randomised controlled trial is to compare the effect of IHGT with a frequency of 2 or 4 sessions/week on resting blood pressure., conditionsModule conditions: Blood Pressure, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 45, type: ESTIMATED, armsInterventionsModule interventions name: Isometric Handgrip Exercise Training (IHGT), outcomesModule primaryOutcomes measure: Resting Systolic Blood Pressure, secondaryOutcomes measure: Resting Diastolic Blood Pressure, secondaryOutcomes measure: Resting Mean Arterial Blood Pressure, otherOutcomes measure: Ratings of perceived exertion, otherOutcomes measure: Affective Valence, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule locations facility: National Taiwan Normal University, status: RECRUITING, city: Taipei, country: Taiwan, contacts name: Yung-Chih Chen, PhD, role: CONTACT, geoPoint lat: 25.04776, lon: 121.53185, locations facility: Swansea University, status: RECRUITING, city: Swansea, country: United Kingdom, contacts name: Richard Metcalfe, role: CONTACT, phone: 01792205678, phoneExt: 4779, email: r.s.metcalfe@swansea.ac.uk, geoPoint lat: 51.62079, lon: -3.94323, hasResults: False