protocolSection identificationModule nctId: NCT06322719, orgStudyIdInfo id: INVIBLADE, briefTitle: Hyperangulated vs Macintosh Blades for Intubation With Videolaryngoscopy in ICU, acronym: INVIBLADE, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2024-05-01, completionDateStruct date: 2024-05-30, studyFirstPostDateStruct date: 2024-03-21, lastUpdatePostDateStruct date: 2024-03-21, sponsorCollaboratorsModule leadSponsor name: Hospital Clinico Universitario de Santiago, class: OTHER, descriptionModule briefSummary: Tracheal intubation in the intensive care unit (ICU) is associated with high incidence of difficult intubation and complications. Videolaryngoscopes (VLs) devices have been proposed to improve airway management, and the use of VLs are recommended as first-line or after a first-attempt failure using direct laryngoscopy in ICU airway management algorithms. Although until relatively few years ago there were doubts about whether videolaryngoscopes had advantages over direct laryngoscopy for endotracheal intubation (ETI) in critically ill patients, two recent studies (DEVICE (1), INTUBATE (2)), and a Cochrane review (3) have confirmed that videolaryn should be used?, and what is the best blade? . There are two types of blades commonly used with videolaryngoscopes: the "Macintosh" blade with a slight curvature, and hyperangulated blades. The "Macintosh" blades have a lower angle of vision, but they have the advantage of being similar to the blades commonly used in direct laryngoscopy, making them easy to use for the person performing the ETI. Hyperangulated blades have a greater angle of vision, improving glottic visualization, especially in patients with an anterior glottis. However, the need to overcome this angulation could potentially hinder the passage of the endotracheal tube to the vocal cords. It is unknown if either blade has any advantage for intubating critically ill patients., conditionsModule conditions: Acute Respiratory Failure, conditions: Intubation, conditions: Intubation; Difficult or Failed, conditions: Videolaryngoscopy, conditions: Intubation Complication, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 1036, type: ESTIMATED, armsInterventionsModule interventions name: Hyperangulated blade videolaryngoscope, interventions name: Macintosh blade videolaryngoscope, outcomesModule primaryOutcomes measure: Difference in the first attempt intubation success rate (percentage), secondaryOutcomes measure: Difference in the overall success rate, secondaryOutcomes measure: Number of intubation attempts, secondaryOutcomes measure: Modified Cormack-Lehane grade of glottic view, secondaryOutcomes measure: Diference in the incidence of "easy intubation", secondaryOutcomes measure: Duration of tracheal intubation, secondaryOutcomes measure: Reason for unsuccessful intubation on the first attempt, secondaryOutcomes measure: Number of videolaryngoscopy attempts, secondaryOutcomes measure: Number of attempts to cannulate the trachea with a bougie or an endotracheal tube, secondaryOutcomes measure: Operator-assessed difficulty of intubation, secondaryOutcomes measure: Need for additional airway equipment, secondaryOutcomes measure: Need to change the device for intubation, secondaryOutcomes measure: Complications of tracheal intubation, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University Clinical Hospital of Santiago de Compostela, city: Santiago de Compostela, state: A Coruña, zip: 15866, country: Spain, geoPoint lat: 42.88052, lon: -8.54569, locations facility: Complexo Hospitalario Universitario de A Coruña, city: A Coruña, country: Spain, contacts name: Pablo Rama, role: CONTACT, email: Pablo.rama.maceiras@sergas.es, geoPoint lat: 43.37135, lon: -8.396, locations facility: Hospital General de Albacete, city: Albacete, country: Spain, contacts name: Luisa María Charco, role: CONTACT, geoPoint lat: 38.99424, lon: -1.85643, locations facility: Hospital de la Santa Creu i Sant Pau, Barcelona, city: Barcelona, country: Spain, contacts name: Marta Giné, role: CONTACT, geoPoint lat: 41.38879, lon: 2.15899, locations facility: Hospital Universitario de Cáceres, city: Cáceres, country: Spain, contacts name: Jose Ignacio Hermoso, role: CONTACT, email: nachomartinez@gmail.com, geoPoint lat: 39.47649, lon: -6.37224, locations facility: Hospital de Denia, city: Denia, country: Spain, contacts name: Marta Carrió, role: CONTACT, geoPoint lat: 38.84078, lon: 0.10574, locations facility: Hospital General Universitario de Eche, city: Elche, country: Spain, contacts name: Ana Pérez, role: CONTACT, geoPoint lat: 38.26218, lon: -0.70107, locations facility: Hospital Universitario de Cabueñes, Gijón, city: Gijón, country: Spain, contacts name: Rosaura María Santamarina, role: CONTACT, geoPoint lat: 43.53573, lon: -5.66152, locations facility: Hospital Virgen de las Nieves, Granada, city: Granada, country: Spain, contacts name: Jose Luis Aguilera, role: CONTACT, geoPoint lat: 37.18817, lon: -3.60667, locations facility: Hospital Universitario de Gran Canaria Doctor Negrín, city: Las Palmas De Gran Canaria, country: Spain, contacts name: Angel Becerra, role: CONTACT, geoPoint lat: 28.09973, lon: -15.41343, locations facility: Complejo Asistencial Universitario de León, city: León, country: Spain, contacts name: Inmaculada Fernández, role: CONTACT, geoPoint lat: 42.60003, lon: -5.57032, locations facility: Hospital Universitario Lucus Augusti, Lugo, city: Lugo, country: Spain, contacts name: María Bermúdez, role: CONTACT, geoPoint lat: 43.00992, lon: 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Hospital Ribera Povisa Vigo, city: Vigo, country: Spain, contacts name: Rafael Cabadas, role: CONTACT, geoPoint lat: 42.23282, lon: -8.72264, hasResults: False