protocolSection identificationModule nctId: NCT06286826, orgStudyIdInfo id: ATRESO, briefTitle: A Study of Patients Undergoing Surgical Treatment for Oesophageal Atresia, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-10-12, primaryCompletionDateStruct date: 2024-10-12, completionDateStruct date: 2026-01-12, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Meyer Children's Hospital IRCCS, class: OTHER, descriptionModule briefSummary: Oesophageal atresia (EA) is a rare congenital anomaly whose prevalence varies between 1 and 2 per 5000 live births in Europe. This condition is characterised by an interruption of the oesophagus often associated with the presence of a tracheo-oesophageal fistula (FTE).Although considerable progress has been made in the treatment of AE in recent years, the aetiology of this defect is still not fully understood and several theories have been put forward to explain this phenomenon. What they have in common is an abnormal separation of the primary oesophagus and trachea. The main goal of AE treatment is the closure of the FTE using surgical techniques.This is a non-profit, multicentre longitudinal observational cohort study. This study will enrol patients who underwent surgery for oesophageal atresia during the period 2011-2021 and are still in follow-up at participating clinical centres.The primary objective is to assess the incidence of musculoskeletal abnormalities, of any type, in the long term (4 years after surgery) in patients with oesophageal atresia treated surgically by two different approaches: postero-lateral thoracotomy and mini-thoracotomy with muscle preservation, conditionsModule conditions: Atresia Esophagus, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Postero-lateral thoracotomy, interventions name: Minithoracotomy, outcomesModule primaryOutcomes measure: incidence of musculoskeletal abnormalities patients with oesophageal atresia treated surgically, secondaryOutcomes measure: incidence of musculoskeletal abnormalities in the short term, secondaryOutcomes measure: incidence of musculoskeletal abnormalities in the medium term, secondaryOutcomes measure: Evaluation of severity of outcomes in the medium, short and long term, secondaryOutcomes measure: Predective Facotrs evaluation, eligibilityModule sex: ALL, minimumAge: 1 Day, maximumAge: 13 Years, stdAges: CHILD, contactsLocationsModule locations facility: Spedali Civili di Brescia, status: RECRUITING, city: Brescia, zip: 25123, country: Italy, contacts name: Daniele Alberti, role: CONTACT, email: daniele.alberti@unibs.it, geoPoint lat: 45.53558, lon: 10.21472, locations facility: Meyer Children's Hospital IRCCS, status: RECRUITING, city: Florence, zip: 50139, country: Italy, contacts name: Elisa Severi, role: CONTACT, phone: 0555662900, email: elisa.severi@meyer.it, geoPoint lat: 43.77925, lon: 11.24626, locations facility: Ospedale Bambino Gesù di Roma, status: RECRUITING, city: Roma, zip: 00165, country: Italy, contacts name: Andrea Conforti, MD, role: CONTACT, email: andrea.conforti@opbg.net, geoPoint lat: 41.89193, lon: 12.51133, hasResults: False