hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06317948, orgStudyIdInfo id: IG23150, briefTitle: Improving the Quality of Radiotherapy by Multi-Institution Knowledge-Based Planning Optimization Models (Acronym: MIKAPOCo, Multi-Institutional Knowledge-based Approach in Plan Optimization for the Community), acronym: MIKAPOCo, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2022-10-28, primaryCompletionDateStruct date: 2022-10-28, completionDateStruct date: 2025-10-28, studyFirstPostDateStruct date: 2024-03-19, lastUpdatePostDateStruct date: 2024-03-20, sponsorCollaboratorsModule leadSponsor name: IRCCS Ospedale San Raffaele, class: OTHER, descriptionModule briefSummary: Investigators central hypothesis is that it is possible to create libraries of "consistent" Knowledge-Based plan-models derived from large Institutional experiences. These libraries can be used to guide automated RT planning and serve as tools to assist centers for plan quality assurance (QA) and plan prediction.Quantifying Inter-institute variability of RT planning and building libraries of interchangeable and validated multi-Institutional KB plan prediction models is expected to impact on the quality of planning at the national level. The project has the potential of facilitating the introduction of AI approaches in plan optimization, thus reducing intra and inter-Institute planning variability. Improving plan quality is expected to translate into better outcome after RT in terms of local control and, even more, of side effects and Quality of life. Positive impact is also expected in patient selection for advanced techniques, in plan audit and plan optimization in clinical trials, in technology comparison and cost-benefit analyses as well as in the RT educational field., conditionsModule conditions: Breast Cancer, conditions: Prostate Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 1000, type: ESTIMATED, armsInterventionsModule interventions name: treatment plan comparison, outcomesModule primaryOutcomes measure: model interchangeability, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: IRCCS Ospedale San Raffaele, city: Milano, zip: 20133, country: Italy, geoPoint lat: 45.46427, lon: 9.18951, hasResults: False
protocolSection identificationModule nctId: NCT06317870, orgStudyIdInfo id: CHUV_PENGIT, briefTitle: Pericapsular Nerve Block Versus Intrathecal Morphine for Analgesia After Primary Hip Arthroplasty, acronym: PENGIT, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2027-01-01, completionDateStruct date: 2027-05-01, studyFirstPostDateStruct date: 2024-03-19, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: Centre Hospitalier Universitaire Vaudois, class: OTHER, descriptionModule briefSummary: The aim of this clinical trial is to compare the analgesic effect of pericapsular nerve block (PENG) with intrathecal morphine in patients scheduled for total hip replacement surgery. The main question to be answered is whether the PENG block is equivalent to intrathecal morphine in reducing postoperative pain.Participants will be randomised into two groups. Patients assigned to the PENG group will receive spinal anaesthesia with local anaesthetic (isobaric bupivacaine) alone and a PENG block. Patients assigned to the intrathecal morphine (ITM) group will receive spinal anaesthesia with a mixture of local anaesthetic (isobaric bupivacaine) and morphine (100 mcg) and a sham PENG block to ensure patient blinding., conditionsModule conditions: Analgesia, conditions: Hip Arthropathy, conditions: Post Operative Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: single centered, prospective, double blinded non inferiority trial, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, maskingDescription: quadruple, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Intrathecal morphine, interventions name: Pericapsular nerve group block (PENG), outcomesModule primaryOutcomes measure: Cumulative postoperative morphine consumption at day 1, secondaryOutcomes measure: Morphine consumption in the recovery room, secondaryOutcomes measure: PCA administered morphine consumption at day 2, secondaryOutcomes measure: rest and dynamic pain scores, secondaryOutcomes measure: Incidence of postoperative nausea and vomiting, secondaryOutcomes measure: Incidence of pruritus, secondaryOutcomes measure: Incidence of urinary retention requiring bladder catheterisation, secondaryOutcomes measure: Duration of analgesia, secondaryOutcomes measure: operated limb quadriceps strength, secondaryOutcomes measure: Walking test, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University Hospital of Lausanne, city: Lausanne, state: Vaud, zip: 1011, country: Switzerland, contacts name: Marta Szyszko du Bois d'Aische, role: CONTACT, phone: +41795564002, email: marta.szyszko@chuv.ch, contacts name: Corey Kull, role: CONTACT, phone: +41795561781, email: corey.kull@chuv.ch, geoPoint lat: 46.516, lon: 6.63282, hasResults: False
protocolSection identificationModule nctId: NCT06317857, orgStudyIdInfo id: 14422021443228, briefTitle: Clinical Performance of an Alkasite-based Restorative Material, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2025-06-30, completionDateStruct date: 2025-06-30, studyFirstPostDateStruct date: 2024-03-19, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: Cairo University, class: OTHER, descriptionModule briefSummary: The evolution of restorative dental materials and technology has enabled the use of tooth-colored restorative materials in dental restorations, with all dentists hoping for the presence of materials that combine biocompatible qualities and aesthetics . Although resin composite materials' mechanical and aesthetic properties have greatly improved over the past 20 years, research is currently on to find ways to prevent secondary caries from forming beneath and at the margins of restorations. In order to circumvent these problems, there is a growing tendency towards the use of resin-based bioactive and remineralizing restorative materials to strengthen and lengthen the lifespan of bonded dental restorations., conditionsModule conditions: Caries, Dental, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 68, type: ESTIMATED, armsInterventionsModule interventions name: Centio Forte, outcomesModule primaryOutcomes measure: Retention success rate % with modified USPH criteria, secondaryOutcomes measure: Marginal adaptation with modified USPH criteria marginal discolouration, recurrent caries, anatomic form and postoperative sensitivity., secondaryOutcomes measure: Postoperative sensitivity, eligibilityModule sex: ALL, minimumAge: 16 Years, maximumAge: 55 Years, stdAges: CHILD, stdAges: ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06317844, orgStudyIdInfo id: BlackHillsHealthPsych, secondaryIdInfos id: P20GM103443, type: NIH, link: https://reporter.nih.gov/quickSearch/P20GM103443, briefTitle: Examination of Psychological and Physiological Pathways Linking Gratitude and Pain, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-09, primaryCompletionDateStruct date: 2026-08, completionDateStruct date: 2027-05, studyFirstPostDateStruct date: 2024-03-19, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: Black Hills State University, class: OTHER, collaborators name: National Institute of General Medical Sciences (NIGMS), descriptionModule briefSummary: The goal of this clinical trial is to compare the effects of a brief gratitude intervention on individuals' psychological and physiological responses to acute pain. Furthermore, these associations will be examined in the context of genetic variations associated with both pain and psychological processes., conditionsModule conditions: Acute Pain, conditions: Positive Thinking, conditions: Emotions, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 300, type: ESTIMATED, armsInterventionsModule interventions name: Behavioral Writing Intervention, outcomesModule primaryOutcomes measure: Change in Subjective Pain Ratings from Baseline to 10-minutes Post Cold Pressor Test, primaryOutcomes measure: Differences in Pain Tolerance to Cold Pressor Test, primaryOutcomes measure: Differences in Pain Onset to Cold Pressor Test, secondaryOutcomes measure: Differences in Pain-Related Cognition, secondaryOutcomes measure: Differences in Autonomic Nervous System Responsivity, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06317818, orgStudyIdInfo id: TJT2301, briefTitle: Is Local Injection of Mesenchymal Stem Cells After Endoscopic Dilation Safe and Does it Improve the Outcome of Intestinal Stricture in Patients With Crohn's Disease?, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-06-06, primaryCompletionDateStruct date: 2025-08, completionDateStruct date: 2025-08, studyFirstPostDateStruct date: 2024-03-19, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: Centre Hospitalier Universitaire de Liege, class: OTHER, descriptionModule briefSummary: This is an exploratory phase II study, to evaluate the impact of these Mesenchymal Stem Cells (MSCs) on strictures in Crohn's disease patients with symptomatic intestinal stricture eligible to endoscopic dilatation. The impact of combined treatment by endoscopic dilation and local injection of MSCs will be compared with that of a control group., conditionsModule conditions: Safety Issues, conditions: Efficacy, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized, double-blind, controlled study, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Mesenchymal Stem Cells, interventions name: Comparative placebo, outcomesModule primaryOutcomes measure: Assessment of safety of local MSCs injection, in association with endoscopic dilation, in strictures of patients with Crohn's disease., primaryOutcomes measure: Assessment of efficacy of local MSCs injection, in association with endoscopic dilation, in strictures of patients with Crohn's disease by evaluating symptomatic clinical response, primaryOutcomes measure: Assessment of efficacy of local MSCs injection, in association with endoscopic dilation, in strictures of patients with Crohn's disease by evaluating endoscopic response, primaryOutcomes measure: Assessment of efficacy of local MSCs injection, in association with endoscopic dilation, in strictures of patients with Crohn's disease by evaluating radiological response, secondaryOutcomes measure: Evaluation of studying, in addition to biomarkers (CRP and fecal calprotectin),, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: CHU de Liège, status: RECRUITING, city: Liège, zip: 4000, country: Belgium, contacts name: Sophie Vieujean, MD, role: CONTACT, phone: + 32 4 323 72 56, email: s.vieujean@chuliege.be, contacts name: Layla Boutaffala, role: CONTACT, phone: +32 4 323 38 10, email: lboutaffala@chuliege.be, geoPoint lat: 50.63373, lon: 5.56749, hasResults: False
protocolSection identificationModule nctId: NCT06317792, orgStudyIdInfo id: 202201719B0, briefTitle: The Efficacy of Online Exergaming-Integrated Physiotherapy for Parkinson's Disease, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2026-03-31, completionDateStruct date: 2026-06-30, studyFirstPostDateStruct date: 2024-03-19, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: Chang Gung Memorial Hospital, class: OTHER, collaborators name: National Science and Technology Council, descriptionModule briefSummary: To validate the efficiency of online exergaming-based physiotherapy. We will enroll patients with Parkinson's disease in postural instability and gait disturbance motor phenotype in the study and divide them into two groups in a randomized controlled study., conditionsModule conditions: Parkinsonism in Diseases Classified Elsewhere, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Participants will be divided into two groups in a randomized controlled study, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: online exergaming-based physiotherapy programs, outcomesModule primaryOutcomes measure: Unified Parkinson's Disease Rating Scale score assessment, primaryOutcomes measure: Tinetti balance and gait score assessment, secondaryOutcomes measure: Fall Risk assessment using Berg Balance Scale, secondaryOutcomes measure: Depression severity assessment, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, city: Kaohsiung, zip: 83304, country: Taiwan, geoPoint lat: 22.61626, lon: 120.31333, hasResults: False
protocolSection identificationModule nctId: NCT06317779, orgStudyIdInfo id: abdominal laparotomy, briefTitle: Evaluation of Laparoscopic Cholecystectomy and Concomitant Paraumbilical Hernia Repair, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2026-02-01, completionDateStruct date: 2027-03-01, studyFirstPostDateStruct date: 2024-03-19, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: Umbilical hernia frequently accompanies cholelithiasis. It is possible to repair these hernias after completing cholecystectomy., conditionsModule conditions: Abdominal Disorder, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: RETROSPECTIVE, enrollmentInfo count: 50, type: ESTIMATED, outcomesModule primaryOutcomes measure: Evaluation of Laparoscopic cholecystectomy and concomitant paraumbilical hernia repair, secondaryOutcomes measure: Secondary outcomes measures, eligibilityModule sex: ALL, minimumAge: 10 Years, maximumAge: 90 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06317753, orgStudyIdInfo id: UMinho1, briefTitle: Can Exercise Rewire the Brain Addiction Circuitry?, acronym: REWIRED, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2025-01, primaryCompletionDateStruct date: 2027-12, completionDateStruct date: 2027-12, studyFirstPostDateStruct date: 2024-03-19, lastUpdatePostDateStruct date: 2024-03-22, sponsorCollaboratorsModule leadSponsor name: University of Minho, class: OTHER, descriptionModule briefSummary: The aim of the present study is to apply neuroimaging techniques to investigate how physical exercise may influence the addiction circuitry, ultimately reducing alcohol consumption and craving in youth binge drinkers. This proposal will advance knowledge on how exercise may modulate the neurocircuitry of addiction. Uncovering the neurobiological mechanisms underlying the interactive neural effects of exercise and alcohol intake may provide additional scientific insights for the development of preventive and intervention programs for youth BD and AUD., conditionsModule conditions: Physical Exercise, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: The protocol includes a randomized controlled trial with a follow-up at three months involving three groups of adolescents (18-24 Y) -experimental group 1, will be enrolled in the Aerobic program, experimental group 2 will be involved in the agility program, and an active control group that will be participating in a stretching program. Participants will be randomly assigned to each group., primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Aerobic Exercise, interventions name: Agility-Cognitive Exercise, interventions name: Stretching/relaxation, outcomesModule primaryOutcomes measure: Behavioral: alcohol consumption, primaryOutcomes measure: Behavioral: binge episodes, primaryOutcomes measure: Behavioral : drunkenness, primaryOutcomes measure: Psychological (craving levels), primaryOutcomes measure: Brain structure, primaryOutcomes measure: Brain structural connectivity- FA, primaryOutcomes measure: Brain structural connectivity - MD, primaryOutcomes measure: Brain structural connectivity - AD, primaryOutcomes measure: Brain structural connectivity - RD, primaryOutcomes measure: Brain function, primaryOutcomes measure: Brain function-resting state, secondaryOutcomes measure: Monetary Incentive Delay Task (included in the fMRI paradigm) - hits, secondaryOutcomes measure: Monetary Incentive Delay Task (included in the fMRI paradigm) - reaction time, secondaryOutcomes measure: Maximal oxygen consumption (VO2max), secondaryOutcomes measure: Brain-derived neurotrophic factor (BDNF), secondaryOutcomes measure: Dopamine, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 24 Years, stdAges: ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06317740, orgStudyIdInfo id: 0306369, briefTitle: Green Management Intervention Program For Nurse Managers, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-04-01, primaryCompletionDateStruct date: 2023-12-31, completionDateStruct date: 2023-12-31, studyFirstPostDateStruct date: 2024-03-19, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: Matrouh University, class: OTHER, descriptionModule briefSummary: Green management is the organization-wide strategy that aims to integrate environmental sustainability development into organizational management procedures for maintaining safety and striving high quality of care. The study aimed to examine the effect of a randomized trial of a green management intervention program on nurse manager outcomes., conditionsModule conditions: Intervention, conditions: Knowledge, Attitudes, Practice, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: A randomized controlled trial using two-group pretest-posttest designs, primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: SINGLE, maskingDescription: The study was carried out as a randomized controlled trial using two-group pretest-posttest designs in which the intervention group received an intervention program, in contrast to the comparison group. The study design of the present work followed the CONSORT 2010statement, whoMasked: PARTICIPANT, enrollmentInfo count: 200, type: ACTUAL, armsInterventionsModule interventions name: green management intervention program, outcomesModule primaryOutcomes measure: Questionnaire to measure nurse managers' knowledge, primaryOutcomes measure: Questionnaires to measure nurse manager outcomes, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Faculty of Nursing, Matrouh University, city: Marsa Matruh, zip: 002, country: Egypt, geoPoint lat: 31.3529, lon: 27.23725, hasResults: False
protocolSection identificationModule nctId: NCT06317727, orgStudyIdInfo id: IRAS 337105, briefTitle: PULSed Field ablAtion of coloRectal Polyps, acronym: PULSAR, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2024-11, completionDateStruct date: 2030-05, studyFirstPostDateStruct date: 2024-03-19, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: King's College Hospital NHS Trust, class: OTHER, collaborators name: Mirai Medical, descriptionModule briefSummary: The goal of this observational study is to learn about the role of electroporation (the use of small electric pulses applied to tissue) in the treatment (ablation) of colorectal polyps. The main questions to answer in this pilot phase of the study are:1. The safety of pulsed field ablation (PFA) for the removal of colorectal polyps2. The efficacy and feasibility of PFA in the treatment of colorectal polyps using metrics such as treatment coverage, treatment time, post treatment fibrosis, post treatment recurrence and patient satisfaction, conditionsModule conditions: Colon Polyp, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Irreversible Electroporation using EndoVE(Endoscopic Vacuum Electrode) and electrical pulses generated using ePORE(electroporation device), outcomesModule primaryOutcomes measure: Incidence of Treatment-Emergent Adverse Events, secondaryOutcomes measure: Efficacy of pulsed field ablation in the treatment of colorectal polyps, secondaryOutcomes measure: Efficacy of pulsed field ablation in the treatment of colorectal polyps, secondaryOutcomes measure: Efficacy of pulsed field ablation in the treatment of colorectal polyps, secondaryOutcomes measure: Efficacy of pulsed field ablation in the treatment of colorectal polyps, secondaryOutcomes measure: Efficacy of pulsed field ablation in the treatment of colorectal polyps, secondaryOutcomes measure: Efficacy of pulsed field ablation in the treatment of colorectal polyps, secondaryOutcomes measure: Evaluation of Quality of Life following pulsed field ablation treatment of colorectal polyps, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False