protocolSection identificationModule nctId: NCT06344559, orgStudyIdInfo id: 2023001006, briefTitle: Brain Criticality, Oculomotor Control, and Cognitive Effort, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-12-30, completionDateStruct date: 2026-06-01, studyFirstPostDateStruct date: 2024-04-03, lastUpdatePostDateStruct date: 2024-04-03, sponsorCollaboratorsModule leadSponsor name: Rutgers, The State University of New Jersey, class: OTHER, descriptionModule briefSummary: The project examines electroencephalography, MRI, and behavioral measures indexing flexibility (critical state dynamics) in the brain when healthy young adults do demanding cognitive tasks, and in response to transcranial magnetic stimulation., conditionsModule conditions: Healthy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, interventionModelDescription: The study will involve three sessions of within-subject, crossover, double-blind transcranial magnetic stimulation with either 1) active intermittent theta burst stimulation, 2) active continuous theta burst stimulation or 3) sham intermittent or continuous theta burst stimulation., primaryPurpose: BASIC_SCIENCE, maskingInfo masking: DOUBLE, maskingDescription: Participants numbers will be assigned three blinded codes which are linked with either sham, active continuous, or active intermittent theta burst stimulation in the stimulator protocol. The investigator will enter the code to initiate the corresponding stimulator protocol, but will not know which protocol is active.Half of participants will be assigned a sham code corresponding to sham continuous theta burst stimulation and half will be assigned a sham code corresponding to sham intermittent theta burst stimulation. So, for any given session, either continuous or intermittent theta burst stimulation will be used, but it will be unclear whether the stimulation is active or sham., whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: transcranial magnetic stimulation, outcomesModule primaryOutcomes measure: Critical dynamics - immediate effects of cTBS versus sham stimulation, primaryOutcomes measure: Functional E/I balance - immediate effects of cTBS versus sham stimulation, primaryOutcomes measure: Avalanche branching ratio - immediate effects of cTBS versus sham stimulation, primaryOutcomes measure: Critical dynamics - immediate effects of iTBS versus sham stimulation, primaryOutcomes measure: Functional E/I balance - immediate effects of iTBS versus sham stimulation, primaryOutcomes measure: Avalanche branching ratio - immediate effects of iTBS versus sham stimulation, primaryOutcomes measure: Memory-guided saccade accuracy - effects of cTBS versus sham stimulation, primaryOutcomes measure: Memory-guided saccade accuracy - effects of iTBS versus sham stimulation, primaryOutcomes measure: Anti-saccade accuracy - effects of cTBS versus sham stimulation, primaryOutcomes measure: Anti-saccade accuracy - effects of iTBS versus sham stimulation, primaryOutcomes measure: Subjective effort discounting - cTBS versus sham stimulation, primaryOutcomes measure: Subjective effort discounting - iTBS versus sham stimulation, primaryOutcomes measure: Subjective effort rating - cTBS versus sham stimulation, primaryOutcomes measure: Subjective effort rating - iTBS versus sham stimulation, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule, documentSection largeDocumentModule largeDocs typeAbbrev: Prot, hasProtocol: True, hasSap: False, hasIcf: False, label: Study Protocol, date: 2024-03-17, uploadDate: 2024-03-27T17:23, filename: Prot_000.pdf, size: 1099938, largeDocs typeAbbrev: ICF, hasProtocol: False, hasSap: False, hasIcf: True, label: Informed Consent Form, date: 2023-07-30, uploadDate: 2024-03-27T17:01, filename: ICF_001.pdf, size: 711815, hasResults: False