protocolSection identificationModule nctId: NCT06322420, orgStudyIdInfo id: MoodHab, briefTitle: Behavioral Activation for Depression and Habitual Rumination, acronym: MoodHab, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-09, primaryCompletionDateStruct date: 2025-07-01, completionDateStruct date: 2026-02-01, studyFirstPostDateStruct date: 2024-03-21, lastUpdatePostDateStruct date: 2024-03-21, sponsorCollaboratorsModule leadSponsor name: Ragnar Pétur Ólafsson, class: OTHER, collaborators name: The Icelandic Centre for Research, descriptionModule briefSummary: Depressive rumination, a negative thinking style characterized by repetitive and passive thoughts about the causes, meanings, and consequences of one's feelings and distress, is often described as being a habitual response tendency that forms a vulnerability to depression. Behavioural Activation (BA) is an effective treatment for depression but little is known of mechanisms of changes during a successful treatment completion and for whom the treatment benefits the most. The main purpose of the study is to investigate whether habit-like mood-reactive rumination will change during Behavioral Activation treatment for current depression and mediates symptom changes in the treatment. Important moderators of change will also be investigated (i.e. history of early life stress and cognitive flexibility). We aim to provide individual BA treatment for up to 130 currently depressed participants in 12 treatment sessions over 11 weeks. Measures are obtained at pre-treatment, during treatment, at post-treatment and at 6 month follow up., conditionsModule conditions: Major Depressive Disorder, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 130, type: ESTIMATED, armsInterventionsModule interventions name: Behavioural Activation (BA), outcomesModule primaryOutcomes measure: Symptom severity measured by the BDI-2, primaryOutcomes measure: Disorder severity assessed with the DIAMOND diagnostic interview - Major Depressive Disorder, primaryOutcomes measure: Diagnostic status assessed with the DIAMOND diagnostic interview - Major Depressive Episode, secondaryOutcomes measure: Symptom severity measured on the PHQ-9, secondaryOutcomes measure: Momentary negative and positive affectivity using items from the PANAS (Positive and Negative Affect Schedule), secondaryOutcomes measure: Diagnostic status assessed with the DIAMOND diagnostic interview at follow -up - Major Depressive Episode, secondaryOutcomes measure: Diagnostic status assessed with the DIAMOND diagnostic interview at follow-up- Major Depressive Disorder, secondaryOutcomes measure: The Quality of Life Scale (QOLS), otherOutcomes measure: Generalized Anxiety Disorder-7 (GAD-7), otherOutcomes measure: The Snaith-Hamilton Pleasure Scale (SHAPS), otherOutcomes measure: Beck Anxiety Inventory (BAI), otherOutcomes measure: The Ruminative Response Scale (RRS), otherOutcomes measure: The Pearlin Mastery Scale (PMS), otherOutcomes measure: The Environmental Reward Observation Scale (EROS), otherOutcomes measure: Behavioral Activation for Depression Scale (BADS), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Iceland, status: RECRUITING, city: Reykjavík, zip: 102, country: Iceland, contacts name: Ragnar P Ólafsson, PhD, role: CONTACT, phone: 8622245, phoneExt: 00354, email: ragnarpo@hi.is, contacts name: Sigurður Viðar, Cand.Psych, role: SUB_INVESTIGATOR, contacts name: Nína B Arnardóttir, MS, role: SUB_INVESTIGATOR, contacts name: Ívar Snorrason, PhD, role: SUB_INVESTIGATOR, contacts name: Igor Marchetti, PhD, role: SUB_INVESTIGATOR, geoPoint lat: 64.13548, lon: -21.89541, hasResults: False