hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06355765, orgStudyIdInfo id: CITIZ_001, briefTitle: Citicoline & Antioxidants in Glaucoma, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-01-10, primaryCompletionDateStruct date: 2022-12-10, completionDateStruct date: 2022-12-10, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: University of Naples, class: OTHER, descriptionModule briefSummary: To evaluate the long-term effects of oral citicoline, vitamins A, B, C and E, and blackcurrant therapy in patients with primary open-angle glaucoma (POAG) using optical coherence tomography (OCT), OCT angiography (OCTA) and microperimetry parameters., conditionsModule conditions: Glaucoma, Open-Angle, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 60, type: ACTUAL, armsInterventionsModule interventions name: Citicoline blackcurrant supplement, outcomesModule primaryOutcomes measure: Evaluation of Ganglionar cells complex (GCC), secondaryOutcomes measure: Evaluation of Retinal nerve fiber layer (RNFL), eligibilityModule sex: ALL, minimumAge: 30 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Naples Federico II, city: NAples, zip: 80131, country: Italy, geoPoint lat: 40.85216, lon: 14.26811, hasResults: False
protocolSection identificationModule nctId: NCT06355752, orgStudyIdInfo id: 0018-N-23, briefTitle: Biomarkers of Pain and Stress Perception and Dry Needling Technique Application, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-12, primaryCompletionDateStruct date: 2024-07-15, completionDateStruct date: 2024-07-15, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-16, sponsorCollaboratorsModule leadSponsor name: University of Alcala, class: OTHER, descriptionModule briefSummary: The use of the dry needling technique has become widespread in recent years for the treatment of musculoskeletal pain. Although dry needling has been shown to be effective in the treatment of shoulder pain, elbow pain, headache, etc., we do not yet have a clear understanding of the mechanisms of action that justify its beneficial effects.In this study, we propose to analyse the biochemical markers of pain generated by the application of a dry needling technique on the lumbar musculature in patients with mechanical lumbar pain of non-specific origin.The aim of this study will be to evaluate the effects of dry needling technique on the plasmatic concentration of biochemical markers.Furthermore, the test subjects will be randomly distributed into two groups.An experimental group where the subjects will receive a real dry needling technique.Another group will be treated with a sham technique., conditionsModule conditions: Low Back Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 36, type: ESTIMATED, armsInterventionsModule interventions name: Dry needling of lumbar iliocostalis muscle, interventions name: Sham dry needling lumbar iliocostalis muscle, outcomesModule primaryOutcomes measure: Extracting Blood Samples and Obtaining Serum/Plasma, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Centro Investigación Fisioterapia y Dolor, status: RECRUITING, city: Alcalá De Henares, state: Madrid, zip: 28805, country: Spain, contacts name: Patricia Martinez-Merinero, PhD, role: CONTACT, phone: 683378391, email: info@institutofisioterapiaydolor.es, contacts name: Laura Cabellos, role: CONTACT, phone: 683378391, email: clinica.fisio@fgua.es, geoPoint lat: 40.48205, lon: -3.35996, hasResults: False
protocolSection identificationModule nctId: NCT06355739, orgStudyIdInfo id: BIC-19GG, BIC-2019,BIC-2219, briefTitle: CD19-targeted CAR T Cell Autotransfusion for the Treatment of Recurrent/Refractory B-cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma in Children With CD19+, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-01, primaryCompletionDateStruct date: 2026-12-01, completionDateStruct date: 2027-01-15, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Zhu Xiaofan, class: OTHER, descriptionModule briefSummary: To evaluate the safety and efficacy of BIC-19GG, BIC-2019, BIC-2219 in the treatment of relapsed/refractory B acute lymphoblastic leukemia/lymphoblastic lymphoma in children, conditionsModule conditions: B Lymphocytic Leukemia, conditions: B Lymphoblastic Lymphoma, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: CAR T cell injection, outcomesModule primaryOutcomes measure: Overall survival and event-free survival, secondaryOutcomes measure: Overall remission rate, secondaryOutcomes measure: Adverse events, eligibilityModule sex: ALL, minimumAge: 3 Years, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Department of Pediatrics, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences, status: RECRUITING, city: Tianjin, state: Tianjin, zip: 300020, country: China, contacts name: Xiaofan Zhu, MD, role: CONTACT, phone: 86-21-23909001, email: xfzhu@ihcams.ac.cn, contacts name: Jingliao Zhang, MD, role: SUB_INVESTIGATOR, geoPoint lat: 39.14222, lon: 117.17667, locations facility: InstituteHBDH, status: NOT_YET_RECRUITING, city: Tianjin, state: Tianjin, zip: 300020, country: China, contacts name: Zhu Xiaofan, role: CONTACT, phone: 86-21-23909001, email: xfzhu@ihcams.ac.cn, contacts name: Guo Ye, role: PRINCIPAL_INVESTIGATOR, contacts name: Yang Wenyu, role: PRINCIPAL_INVESTIGATOR, contacts name: Chen Xiaojuan, role: PRINCIPAL_INVESTIGATOR, contacts name: Chen Yumei, role: PRINCIPAL_INVESTIGATOR, contacts name: Ruan Min, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.14222, lon: 117.17667, hasResults: False
protocolSection identificationModule nctId: NCT06355700, orgStudyIdInfo id: 5476, briefTitle: Hepatocellular Carcinoma Liver Organoids, acronym: HELIO, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-06-15, primaryCompletionDateStruct date: 2025-03, completionDateStruct date: 2025-03, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS, class: OTHER, descriptionModule briefSummary: The goal of this interventional study is to create hepatocellular carcinoma organoids from liver bioptic samples of individuals with hepatocellular carcinoma. The main questions it aims to answer are:* the feasibility of hepatocellular carcinoma organoids integrated with host gut microbiota and peripheral blood mononuclear cells* the molecular pattern of the organoid tumor microenvironment* the in vitro therapeutic response of hepatocellular carcinoma organoids, conditionsModule conditions: Hepatocellular Carcinoma, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: Liver biopsy, outcomesModule primaryOutcomes measure: Success rate of hepatocellular carcinoma organoids integrated with host gut microbiota and peripheral blood mononuclear cells, secondaryOutcomes measure: Analysis of hepatocellular carcinoma organoid transcriptome distribution within a reference set from The Cancer Genome Atlas, secondaryOutcomes measure: Evaluation of the concordance of somatic genetic mutations between the organoid and the original tumor, secondaryOutcomes measure: Correlation between gut microbiota community profiling and growth rate of hepatocellular carcinoma organoids, secondaryOutcomes measure: Treatment response evaluation in vitro, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Fondazione Policlinico Agostino Gemelli IRCCS, status: RECRUITING, city: Roma, zip: 00168, country: Italy, contacts name: Francesca Ponziani, MD, role: CONTACT, phone: +390630156018, email: comitato.etico@policlinicogemelli.it, geoPoint lat: 41.89193, lon: 12.51133, hasResults: False
protocolSection identificationModule nctId: NCT06355687, orgStudyIdInfo id: FMASU MD304/2023, briefTitle: Melatonin in Obese Patients in Laparoscopic Cholecystectomy, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2025-04, completionDateStruct date: 2025-04, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Ain Shams University, class: OTHER, descriptionModule briefSummary: Opioid free anesthesia (OFA) means a technique in which no intraoperative opioid is administered through any route. Perioperative pain management in an obese patient is challenging. The incidence of respiratory depression is higher in obese patients and is exaggerated with opioids, so the investigators are searching for a drug that has analgesic effect without any effect on respiratory function. In this study, the investigators will add melatonin to OFA in obese patients undergoing laparoscopic cholecystectomy., conditionsModule conditions: Anesthesia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Melatonin, interventions name: Vitamin Supplement, outcomesModule primaryOutcomes measure: Postoperative Pain., secondaryOutcomes measure: Postoperative Pain., secondaryOutcomes measure: Analgesics usage., secondaryOutcomes measure: Postoperative nausea and vomiting., secondaryOutcomes measure: Recovery time., secondaryOutcomes measure: Number of participants with hemodynamic instability., secondaryOutcomes measure: Number of participants with hemodynamic instability., eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06355674, orgStudyIdInfo id: HRÜ/23.21.12, briefTitle: Adolescent Mother and Breastfeeding Education, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-15, primaryCompletionDateStruct date: 2024-09-15, completionDateStruct date: 2024-10-15, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Adiyaman University, class: OTHER, descriptionModule briefSummary: In low-income and developing countries, 30% of adolescents marry before the age of 18, and 14% marry before the age of 15. Additionally, adolescents between the ages of 15 and 19 are often coerced into marriage or sexual relationships with partners older than themselves. 10% of adolescents under the age of 15 in the world are forced to have sexual intercourse and as a result, unwanted teenage pregnancies occur. In high-income countries like Latin America, there is a high prevalence of adolescent non-marital pregnancies. When considering the fertility, health, and social outcomes of adolescence, it emerges as a significant issue. Adolescent motherhood carries numerous adverse effects from both demographic and social perspectives.In pregnancies occurring during adolescence, both maternal and infant mortality rates are two to three times higher compared to pregnancies at later ages. Many infant and child deaths occur due to preventable causes. Breastfeeding is a significant factor in reducing infant and child mortality. Since infants born to adolescent mothers are at higher risk of death and illness, breastfeeding these infants becomes even more important. However, one of the significant challenges adolescent mothers face during the postpartum period is initiating and maintaining lactation. Research has shown that maternal age plays a significant role in initiating and sustaining breastfeeding, with a strong positive correlation between maternal age and duration of breastfeeding. This study was designed as a randomized controlled trial to examine the effect of breastfeeding education provided to adolescent mothers on maternal breastfeeding self-efficacy, mother-infant attachment, and infant anthropometric measurements., conditionsModule conditions: Adolescent Mother, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: NONE, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Breastfeeding education provided with Lactation Simulation Model, outcomesModule primaryOutcomes measure: Postnatal Breastfeeding Self-Efficacy Scale-Short Form, primaryOutcomes measure: Maternal-Infant Attachment Scale, eligibilityModule sex: FEMALE, minimumAge: 12 Years, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06355635, orgStudyIdInfo id: JohannesGUVA, briefTitle: Application and Monitoring of Vasoactive and Inotrope Drugs, acronym: Vasin, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-04, primaryCompletionDateStruct date: 2024-06-01, completionDateStruct date: 2024-11-01, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Johannes Gutenberg University Mainz, class: OTHER, descriptionModule briefSummary: The investigators aimed to establish current practice of application and monitoring of vasoactive and inotrope Drugs in non-cardiac surgery patients., conditionsModule conditions: Hemodynamic Instability, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 1000, type: ESTIMATED, armsInterventionsModule interventions name: Choice and Monitoring, outcomesModule primaryOutcomes measure: current practice of correct application and monitoring of vasoactive and inotrope Drugs, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Department of Anaesthesiology;, status: RECRUITING, city: Mainz, state: Rhineland-Palatinate, zip: D55131, country: Germany, contacts name: Marc Kriege, MD, role: CONTACT, phone: 00496131170, email: MaKriege@uni-mainz.de, geoPoint lat: 49.98419, lon: 8.2791, hasResults: False
protocolSection identificationModule nctId: NCT06355622, orgStudyIdInfo id: 3717, briefTitle: Prevalence and Characterization of Pain in RASopathies, acronym: 3717, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-01-27, primaryCompletionDateStruct date: 2024-01-30, completionDateStruct date: 2024-06-30, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS, class: OTHER, descriptionModule briefSummary: RASopathies are a group of syndromes caused by variants in genes belonging to the RAS/MAPK pathway. Pain is a neglected topic in RASopathies but it is frequently complained by affected individuals., conditionsModule conditions: RASopathy, conditions: Costello Syndrome, conditions: Cardio-Facio-Cutaneous Syndrome, conditions: Noonan Syndrome, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 150, type: ESTIMATED, armsInterventionsModule interventions name: Characterization of pain, outcomesModule primaryOutcomes measure: Prevalence of pain in verbal patients with RASopathies, primaryOutcomes measure: Prevalence of Pain in no-communitating patients with RASopathies, secondaryOutcomes measure: Characterization of pain in RASopathies, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Department of Woman and Child Health and Public Health, Fondazione Policlinico A. Gemelli, IRCCS, status: RECRUITING, city: Roma, zip: 00168, country: Italy, contacts name: Chiara Leoni, MD, PhD, role: CONTACT, phone: 0039063381344, email: chiara.leoni@policlinicogemelli.it, geoPoint lat: 41.89193, lon: 12.51133, hasResults: False
protocolSection identificationModule nctId: NCT06355609, orgStudyIdInfo id: DZ2023EI004-RW, briefTitle: Sunvozertinib Plus Anlotinib as 1L Treatment in EGFR Mutant Advanced NSCLC-RW, acronym: WUKONG-32-RW, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-30, primaryCompletionDateStruct date: 2025-12-30, completionDateStruct date: 2027-12-30, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Hunan Province Tumor Hospital, class: OTHER, descriptionModule briefSummary: This is a phase II, open-label, single-arm, single-center clinical study to evaluate the preliminary efficacy of sunvozertinib in combination with anlotinib in patients with EGFR-sensitive mutations and co-mutations in locally advanced or metastatic treatment-naive non-small cell lung cancer., conditionsModule conditions: Non-small Cell Lung Cancer, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: sunvozertinib in combination with Anlotinib, outcomesModule primaryOutcomes measure: Progression-free survival (PFS), secondaryOutcomes measure: Objective Response Rate (ORR), secondaryOutcomes measure: Overall survival (OS), secondaryOutcomes measure: Duration of Response (DoR), secondaryOutcomes measure: Adverse events (AEs) according to CTCAE 5.0, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hunan Cancer Hospital, city: Changsha, state: Hunan, zip: 410013, country: China, geoPoint lat: 28.19874, lon: 112.97087, hasResults: False
protocolSection identificationModule nctId: NCT06355596, orgStudyIdInfo id: 20IC6361, briefTitle: Development and Validation of a Virtual Teaching Method for Minimally Invasive Surgery Skills, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-03-11, primaryCompletionDateStruct date: 2022-04-08, completionDateStruct date: 2022-04-08, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Imperial College London, class: OTHER, descriptionModule briefSummary: The goal of this observational study is to develop and evaluate a virtual teaching method for minimally invasive surgery (MIS) skills among novice learners, using widely available technology and incorporating objective assessments of proficiency. The main questions it aims to answer are:Can MIS skills be effectively taught to novice learners through a virtual platform using widely available technology? How do virtual and face-to-face (F2F) teaching methods compare in terms of effectiveness, measured by performance in MIS tasks and cognitive workload parameters?Participants in this study will:Be randomly allocated to either F2F or virtual teaching groups. Undergo training and evaluation using validated laparoscopic assessments, namely the McGill Inanimate System for Training and Evaluation of Laparoscopic Skills (MISTELS) peg transfer task and the European Academy laparoscopic 'Suturing Training and Testing' (SUTT) assessment.Have their performance and cognitive workload parameters (SURG-TLX score, heart rate, and pupil metrics) evaluated during the tasks., conditionsModule conditions: Surgery, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: SINGLE_GROUP, interventionModelDescription: Participants are randomly allocated to either face-to-face or virtual teaching groups, primaryPurpose: OTHER, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 20, type: ACTUAL, armsInterventionsModule interventions name: Virtual teaching, outcomesModule primaryOutcomes measure: McGill Inanimate System for Training and Evaluation of Laparoscopic Skills (MISTELS) peg transfer task score, primaryOutcomes measure: European Academy laparoscopic 'Suturing Training and Testing' (SUTT) assessment score, secondaryOutcomes measure: SURG-TLX score, secondaryOutcomes measure: Heart rate, secondaryOutcomes measure: Pupil metrics, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: St Mary's Hospital, city: London, zip: W2 1NY, country: United Kingdom, geoPoint lat: 51.50853, lon: -0.12574, hasResults: False