protocolSection identificationModule nctId: NCT06269679, orgStudyIdInfo id: RC23_0336, briefTitle: CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis., acronym: 3D STARS, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2028-05-01, completionDateStruct date: 2028-05-01, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-02-21, sponsorCollaboratorsModule leadSponsor name: Nantes University Hospital, class: OTHER, descriptionModule briefSummary: 1. Infective Endocarditis (IE) is a rare and serious disease with high morbidity and mortality; 2. Streptoccoci of oral origin are the second more frequent microorganisms responsible for IE; 3. Oral Infectious Foci (OIF) are underdetected using the current recommended clinical examination/Orthopantomogram (OPT) approach; 4. Cone Beam Computed Tomography (CBCT) has a better sensitivity and sensibility to detect OIF than OPT; 5. To date, no study has been performed to assess the potential benefit of a clinical examination/CBCT approach on the oral health status in IE patients.Thus, conducting a randomized controlled trial is highly desirable to assess the potential impact of a clinical examination/CBCT approach on the oral health status of patients hospitalized for IE and potentially to reduce IE new episodes., conditionsModule conditions: Infective Endocarditis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 170, type: ESTIMATED, armsInterventionsModule interventions name: CBCT, outcomesModule primaryOutcomes measure: Superiority of CBCT, primaryOutcomes measure: Superiority of CBCT, primaryOutcomes measure: Superiority of CBCT, secondaryOutcomes measure: Diagnostic at inclusion, secondaryOutcomes measure: Incident symptomatic OIF, secondaryOutcomes measure: Incident asymptomatic OIF, secondaryOutcomes measure: Oral hygiene, secondaryOutcomes measure: Follow-up habits, secondaryOutcomes measure: Follow-up habits, secondaryOutcomes measure: Oral health quality of life, secondaryOutcomes measure: Premature end of study, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 100 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: CHU Bordeaux - Site Pellegrin, city: Bordeaux, country: France, contacts name: Elise ARRIVE, role: CONTACT, phone: +33/5 56 79 56 79, email: elise.arrive@u-bordeaux.fr, geoPoint lat: 44.84044, lon: -0.5805, locations facility: CHU Grenoble, city: Grenoble, country: France, contacts name: Cécile CHATEL, role: CONTACT, phone: +33/4 76 76 50 26, email: cchatel1@chu-grenoble.fr, geoPoint lat: 45.16667, lon: 5.71667, locations facility: CHRU Nancy, city: Nancy, country: France, contacts name: Vanessa MOBY, role: CONTACT, phone: +33/3 83 39 18 00, email: vanessa.moby@univ-lorraine.fr, geoPoint lat: 48.68439, lon: 6.18496, locations facility: CHU Nantes, city: Nantes, country: France, contacts name: Philippe LESCLOUS, role: CONTACT, phone: +33/2.40.41.29.40, email: philippe.lesclous@chu-nantes.fr, contacts name: Astrid GARREAU, role: CONTACT, email: astrid.garreau@chu-nantes.fr, geoPoint lat: 47.21725, lon: -1.55336, locations facility: AP-HP - Site Bretonneau, city: Paris, country: France, contacts name: MESSECA Clément, role: CONTACT, phone: +33/1 53 11 18 00, email: clement.messeca@aphp.fr, geoPoint lat: 48.85341, lon: 2.3488, locations facility: CHU Toulouse, city: Toulouse, country: France, contacts name: Sarah COUSTY, role: CONTACT, phone: +33/5.61.32.20.30, email: cousty.s@chu-toulouse.fr, geoPoint lat: 43.60426, lon: 1.44367, locations facility: CHRU Tours, city: Tours, country: France, contacts name: Frédéric DENIS, role: CONTACT, phone: +33/2 47 47 47 47, email: frederic.denis@univ-tours.fr, geoPoint lat: 47.38333, lon: 0.68333, hasResults: False