protocolSection identificationModule nctId: NCT06275204, orgStudyIdInfo id: 101101252, secondaryIdInfos id: 101101252, type: OTHER_GRANT, domain: EU4H-2022-PJ-01, briefTitle: H. Pylori Screen-and-treat Study in a Population of Young Adults, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-04, primaryCompletionDateStruct date: 2026-10-01, completionDateStruct date: 2026-12-01, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: University of Latvia, class: OTHER, collaborators name: Clinical Hospital Center Rijeka, collaborators name: Clinical Hospital Centre Zagreb, collaborators name: Beacon Hospital, collaborators name: Wroclaw Medical University, collaborators name: Iuliu Hatieganu University of Medicine and Pharmacy, collaborators name: National Institute of Public Health, Slovenia, descriptionModule briefSummary: Gastric cancer remains a major challenge to public health on a global scale. H. pylori related cancer burden contributes to the largest proportion of cancer cases attributable to infections in Europe. Considering its absolute burden and persisting disparities, in addition to the substantial prevalence of H. pylori infection worldwide that is treatable, gastric cancer is a logical target for urgent action for prevention. Population-based H. pylori test-and-treat has therefore been proposed as a strategy for gastric cancer prevention. To fill the gaps in knowledge about gastric cancer prevention through H. pylori screening and eradication in younger adults, a study of a population-based H. pylori test-and-treat strategy in Ireland, Croatia, Latvia, Poland, Romania and Slovenia.Main goals of this study are to assess future program processes, feasibility, acceptability and effectiveness. In total of 6,800 adults aged 30-34 will be tested for H. pylori infection. They will be randomly selected to represent the chosen population and invited to participate in the study based on informed consent. Confirmed infections will be treated by available combined therapy in line with treatment guidelines and the success of eradication will be retested during a control check-up.Patients who will provide their consent to participate will undertake an interview about the risk factors in early childhood and their habits regarding alcohol consumption and use of tobacco. Compliance to testing and treatment, treatment results, adverse effects and reasons for dropping out will be additionally monitored. Gathered data will be analysed in alignment with our research questions. The investigators will disseminate reports and present the results to both the general public and the scientific community in order to foster future developments in gastric cancer prevention., conditionsModule conditions: Gastric Cancer, conditions: H Pylori Infection, conditions: H Pylori Eradication, conditions: H-pylori, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 6800, type: ESTIMATED, armsInterventionsModule interventions name: Bismuth-based quadruple therapy, interventions name: Levofloxacin-based quadruple therapy, interventions name: Standard triple therapy, interventions name: Levofloxacin-based triple, outcomesModule primaryOutcomes measure: Healthcare workers' assessment of feasibility and acceptability of the proposed practical implementation of a screening program, secondaryOutcomes measure: Eradication rate of infection with H. pylori, secondaryOutcomes measure: Description of the adverse events profile, secondaryOutcomes measure: Participation rate of subjects selected for the program, eligibilityModule sex: ALL, minimumAge: 30 Years, maximumAge: 34 Years, stdAges: ADULT, contactsLocationsModule locations facility: University Hospital Centre Zagreb, status: RECRUITING, city: Zagreb, state: Grad Zagreb, zip: 10000, country: Croatia, contacts name: Masa Cavlina Sevo, MD, role: CONTACT, phone: 00385995900847, email: masa.cavlina@gmail.com, contacts name: Mirjana Kalauz, Asst. Prof., role: CONTACT, phone: 0038598519088, email: mirjanakalauz1@gmail.com, contacts name: Mirjana Kalauz, Asst. Prof., role: PRINCIPAL_INVESTIGATOR, contacts name: Pave Markos, MD, PhD, role: SUB_INVESTIGATOR, contacts name: Tihomir Bradic, MD, role: SUB_INVESTIGATOR, contacts name: Masa Cavlina Sevo, MD, role: SUB_INVESTIGATOR, geoPoint lat: 45.81444, lon: 15.97798, locations facility: Clinical Hospital Center Rijeka, status: RECRUITING, city: Rijeka, zip: 51000, country: Croatia, contacts name: Sandra Milic, MD, role: CONTACT, phone: 0038551658122, email: smilic05@gmail.com, geoPoint lat: 45.32674, lon: 14.44239, locations facility: Beacon Hospital, status: RECRUITING, city: Dublin, zip: D18 AK68, country: Ireland, contacts name: Charlene Deane, MB Bch BAO, MSc, role: CONTACT, phone: 00353879114305, email: charlene.deane@beaconhospital.ie, contacts name: Ruth Pilkington, MB BcH BAO, role: CONTACT, phone: 0035312937521, email: ruth.pilkington@beaconhospital.ie, contacts name: Colm O Morain, MD, MB BcH BAO, FRCPI, role: PRINCIPAL_INVESTIGATOR, contacts name: Orlaith Kelly, PHD, MB BcH, role: SUB_INVESTIGATOR, contacts name: Charlene Deane, MB Bch BAO, MSc, MRCP, role: SUB_INVESTIGATOR, geoPoint lat: 53.33306, lon: -6.24889, locations facility: Clinical and Preventive Medicine of the University of Latvia, status: NOT_YET_RECRUITING, city: Riga, zip: LV1079, country: Latvia, contacts name: Marcis Leja, MD, PhD, role: CONTACT, phone: 371+29497500, email: marcis.leja@lu.lv, contacts name: Marcis Leja, MD, PhD, role: PRINCIPAL_INVESTIGATOR, contacts name: Danute Razuka Ebela, MD, PhD, role: SUB_INVESTIGATOR, contacts name: Linda Mezmale, MD, role: SUB_INVESTIGATOR, geoPoint lat: 56.946, lon: 24.10589, locations facility: Wroclaw Medical University, status: RECRUITING, city: Wroclaw, zip: 50-367, country: Poland, contacts name: Katarzyna Malinowska, role: CONTACT, phone: 00487178417 99, email: k.malinowska@umw.edu.pl, contacts name: Elzbieta Olejnik, role: CONTACT, phone: 00717841666, email: elzbieta.olejnik@umw.edu.pl, contacts name: Katarzyna Neubauer, MD, PhD, Assoc. Prof., role: PRINCIPAL_INVESTIGATOR, contacts name: Radoslaw Kempinski, MD, PhD, role: SUB_INVESTIGATOR, geoPoint lat: 51.1, lon: 17.03333, locations facility: Iuliu Hatieganu University of Medicine and Pharmacy, status: RECRUITING, city: Cluj-Napoca, state: Cluj County, zip: 400003, country: Romania, contacts name: Dan Lucian Dumitrascu, Prof, role: CONTACT, phone: 0040722756475, email: ddumitrascu@umfcluj.ro, contacts name: Radu Farcas, MD, PhD student, role: CONTACT, phone: 0040757554422, email: radufr@gmail.com, contacts name: Radu Farcas, MD, PhD student, role: SUB_INVESTIGATOR, geoPoint lat: 46.76667, lon: 23.6, locations facility: National Institute of Public Health, Slovenia, status: RECRUITING, city: Ljubljana, zip: 1000, country: Slovenia, contacts name: Mitja Oblak, MSc, role: CONTACT, phone: 0038612441541, email: Mitja.Oblak@nijz.si, contacts name: Tatjana Kofol, MD, role: CONTACT, phone: 0038612441484, email: Tatjana.Kofol@nijz.si, contacts name: Bojan Tepeš, prof., MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.05108, lon: 14.50513, hasResults: False