protocolSection identificationModule nctId: NCT06275009, orgStudyIdInfo id: 2023-1990, briefTitle: Chinese Occupational Population Cohort of Lifestyle and Physical Fitness (LiFitChina), acronym: LiFitChina, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-11, primaryCompletionDateStruct date: 2026-12-11, completionDateStruct date: 2026-12-11, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: China National Center for Cardiovascular Diseases, class: OTHER_GOV, descriptionModule briefSummary: The incidence and prevalence of metabolic risk factors such as obesity, hypertension, diabetes, and dyslipidemia, as well as cardiovascular diseases (CVD), are continuously rising among the occupational population in China, primarily comprising the middle-aged and young adults. Unhealthy lifestyles and declining physical fitness are independent risk factors affecting cardiovascular health. Additionally, the level of physical fitness is influenced by postnatal lifestyles. Lifestyle factors related to cardiovascular health in the occupational population encompass various aspects, including smoking, physical activity, diet, sleep, psychological stress, etc. These factors may interact or have a synergistic effect, necessitating a comprehensive assessment.This project proposes a prospective cohort study design to establish a monitoring cohort for lifestyle and physical fitness among the occupational population. The study will track and follow individuals with or without any CVD metabolic risk factors, collecting information on general status, lifestyle, physical fitness, and health examination data. Exposure factors such as lifestyle and physical fitness will be measured annually, and the occurrence of CVD-related health outcomes will be observed. The aim is to develop a comprehensive evaluation index for cardiovascular health lifestyle, analyze the direct and indirect impacts of lifestyle and physical fitness on the occurrence and development of CVD, and explore potential mediating and moderating effects of physical fitness in the association between lifestyle and cardiovascular health., conditionsModule conditions: Lifestyle, conditions: Physical Fitness, conditions: Cardiovascular Diseases, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 18512, type: ESTIMATED, outcomesModule primaryOutcomes measure: the composite end point of new major adverse cardiovascular events, secondaryOutcomes measure: new incidence of each major adverse cardiovascular events, secondaryOutcomes measure: new incidence of cancer, secondaryOutcomes measure: new incidence of all-cause death, secondaryOutcomes measure: level of systolic pressure, secondaryOutcomes measure: level of diastolic pressure, secondaryOutcomes measure: level of blood lipid, secondaryOutcomes measure: level of BMI, secondaryOutcomes measure: level of maximal oxygen uptake (VO2max), secondaryOutcomes measure: level of metabolic equivalents (METs), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 59 Years, stdAges: ADULT, contactsLocationsModule locations facility: Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, status: RECRUITING, city: Beijing, state: Beijing, country: China, contacts name: Xue Feng, MD PhD, role: CONTACT, phone: +86-15601378512, email: 29611290@qq.com, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False