hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06371456, orgStudyIdInfo id: Ain Shams university 111, briefTitle: A Non Invasive Confirmatory Sign for Correct Epidural Catheter Placement During Normal Vaginal Delivery, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-01, primaryCompletionDateStruct date: 2025-06-01, completionDateStruct date: 2025-08-01, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Ain Shams University, class: OTHER, descriptionModule briefSummary: Epidural anesthesia for pain control during normal vaginal delivery is a blind maneuver and so we need a confirmatory sign for being in the correct epidural space.Loss of resistance sign using air may guide us wrongly as it may occur if we entered into the paravertebral muscles or cavities in the interspinal ligaments.So, additional confirmatory sign beside loss of resistance sign by air is strongly needed.We noticed that after occurence of loss of resistance sign by air and insertion of the epidural catheter a dew was formed on the internal sides of the epidural catheter after aspiration to be sure that there are no blood or cerebrospinal fluid in the catheter.This dew formation (Ramy sign) is characteristic for air in the epidural space when transferred from the warm epidural space (temperature about 38-39 celsius degree) to the colder aspect of the catheter outside the patient which nearly has the same operating room temperature (22 celsius degree).This sign may be associated with correct placement and good function of the epidural catheter., conditionsModule conditions: Normal Delivery Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: epidural catheter placement, outcomesModule primaryOutcomes measure: appearance of the dew sign, secondaryOutcomes measure: epidurogram, secondaryOutcomes measure: visual analogue score, secondaryOutcomes measure: mean blood pressure, secondaryOutcomes measure: mean blood pressure, secondaryOutcomes measure: heart rate, secondaryOutcomes measure: heart rate, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06371443, orgStudyIdInfo id: ayselkokcudogan, briefTitle: Suction and Swalloing Exercises for Premature Babies, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-12-03, primaryCompletionDateStruct date: 2022-06-01, completionDateStruct date: 2022-08-01, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Istanbul Medipol University Hospital, class: OTHER, descriptionModule briefSummary: Underdeveloped oral structures of preterm infants cause feeding problems. Therefore, the development of sucking reflexes of premature babies should be supported.This study aimed to investigate the effect of suck-swallow training on the transition to oral feeding in premature infants.The study was conducted as a randomized controlled experimental trial in the NICU of a public hospital in Istanbul. The study sample consisted of 82 premature infants. Of these infants, 41 were assigned to the experimental group and 41 to the control group. Study data were collected using the investigator-developed Premature Infant Data Collection Form and Early Feeding Skills Assessment Tool. Throughout the study, preterm infants in the experimental group (n=41) were given suck-swallow exercises for 12 minutes once a day before feeding for 14 days. SPSS21 was used to analyze the data., conditionsModule conditions: Premature Infant, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 41, type: ACTUAL, armsInterventionsModule interventions name: Sucking and swallowing exercises, outcomesModule primaryOutcomes measure: The early feeding skills assessment tool (EFS), eligibilityModule sex: ALL, minimumAge: 34 Weeks, maximumAge: 37 Weeks, stdAges: CHILD, contactsLocationsModule locations facility: Medipol University, city: Istanbul, state: Beykoz, zip: 34810, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06371430, orgStudyIdInfo id: Biointelligent Technology Syst, briefTitle: Bone Bioactive Liquid Efficiency in Improving Dental Implant Osteointegration Oral Soft Tissue Hellingand Oral Surgery, acronym: BBLIS, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-04-14, primaryCompletionDateStruct date: 2024-02-14, completionDateStruct date: 2024-06-14, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Biointelligent Technology Systems SL, class: INDUSTRY, collaborators name: Universidad Pública de Navarra, collaborators name: Dasman Diabetes Institute, descriptionModule briefSummary: The investigators implanted 264 Galaxy TS implants (with or without BBL) in 33 patients across both jaws. Implant stability and osseointegration were assessed using Initial Stability Quotient (ISQ) measurements, computed tomography (CBCT) scans and pain evaluations at various intervals post-surgery. Further, implant surfaces were examined using scanning electron microscopy (SEM) and atomic force microscopy (AFM). In vitro studies evaluated the efficacy of BBL on dental pulp pluripotent stem cells (DPPSCs) osteogenesis, and inflammatory factor modulation in human macrophages., conditionsModule conditions: Wound Healing Disorder, conditions: Wounds and Injuries, conditions: Wound Surgical, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: FACTORIAL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 33, type: ESTIMATED, armsInterventionsModule interventions name: Dental Implant insertion and tooth extraction, outcomesModule primaryOutcomes measure: ISQ measurements, primaryOutcomes measure: Pain, secondaryOutcomes measure: CBCTs analysis, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Biointelligent Technology Syst, status: RECRUITING, city: Barcelona, zip: 08009, country: Spain, contacts name: Maher Atari, PhD, role: CONTACT, email: matari@biointelligentsl.com, geoPoint lat: 41.38879, lon: 2.15899, hasResults: False
protocolSection identificationModule nctId: NCT06371417, orgStudyIdInfo id: RAY902CT, briefTitle: Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial), statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-31, primaryCompletionDateStruct date: 2026-06-30, completionDateStruct date: 2026-06-30, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Chugai Pharmaceutical, class: INDUSTRY, descriptionModule briefSummary: This Phase 1b basket trial will investigate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and preliminary efficacy of RAY121, a inhibitor of classical complement pathway, after multiple dose administration in patients with immunological diseases such as antiphospholipid syndrome (APS), bullous pemphigoid (BP), Behçet's Syndrome (BS), dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM) and immune thrombocytopenia (ITP)., conditionsModule conditions: Antiphospholipid Syndrome (APS), conditions: Bullous Pemphigoid (BP), conditions: Behçet's Syndrome (BS), conditions: Dermatomyositis (DM), conditions: Immune-mediated Necrotizing Myopathy (IMNM), conditions: Immune Thrombocytopenia (ITP), designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 144, type: ESTIMATED, armsInterventionsModule interventions name: RAY121, outcomesModule primaryOutcomes measure: Adverse events (AEs), secondaryOutcomes measure: RAY121 concentration, secondaryOutcomes measure: AUCτ, secondaryOutcomes measure: Cmax, secondaryOutcomes measure: Cmin, secondaryOutcomes measure: Active C1s, secondaryOutcomes measure: Total C1s, secondaryOutcomes measure: Complement activity (classical pathway), secondaryOutcomes measure: Anti-RAY121 antibodies, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 85 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Oregon Health & Science University, city: Portland, state: Oregon, zip: 97239, country: United States, geoPoint lat: 45.52345, lon: -122.67621, locations facility: Hokkaido University Hospital, city: Sapporo, state: Hokkaido, zip: 060-0808, country: Japan, geoPoint lat: 43.06667, lon: 141.35, locations facility: Tohoku University Hospital, city: Sendai, state: Miyagi, zip: 980-8574, country: Japan, geoPoint lat: 38.26667, lon: 140.86667, locations facility: Osaka University Hospital, city: Suita, state: Osaka, zip: 565-0871, country: Japan, geoPoint lat: 34.76143, lon: 135.51567, locations facility: Hamamatsu University Hospital, city: Hamamatsu, state: Shizuoka, zip: 431-3192, country: Japan, geoPoint lat: 34.7, lon: 137.73333, locations facility: Toho University Omori Medical Center, city: Ota-ku, state: Tokyo, zip: 143-8540, country: Japan, geoPoint lat: 36.3, lon: 139.36667, hasResults: False
protocolSection identificationModule nctId: NCT06371404, orgStudyIdInfo id: 2000037129, briefTitle: Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-01, primaryCompletionDateStruct date: 2030-06-01, completionDateStruct date: 2031-06-01, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Yale University, class: OTHER, descriptionModule briefSummary: The overall objective of this study it to use Positron Emission Tomography (PET) brain imaging and a radiotracer that measures the epigenetic marker Histone Deacetylase 6 (HDAC6) to examine HDAC6 expression in people with Post-Traumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), or concurrent PTSD and AUD with control groups. While there are a large number of studies conducted in preclinical stress and addiction models, these findings have not been translated to people living with these disorders. We will examine relationships between HDAC6 and clinical variables of interest. Findings could direct treatment development., conditionsModule conditions: Alcohol Use Disorder, conditions: Post Traumatic Stress Disorder, designModule studyType: OBSERVATIONAL, designInfo observationalModel: ECOLOGIC_OR_COMMUNITY, timePerspective: RETROSPECTIVE, enrollmentInfo count: 150, type: ESTIMATED, armsInterventionsModule interventions name: Bavarostat, outcomesModule primaryOutcomes measure: HDAC6 expression in people with Post-Traumatic Stress Disorder, primaryOutcomes measure: HDAC6 expression in people with Alcohol use Disorder, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Yale University, city: New Haven, state: Connecticut, zip: 06518, country: United States, contacts name: Kelly Cosgrove, PhD, role: CONTACT, phone: 203-737-6969, email: kelly.cosgrove@yale.edu, contacts name: Marc Grasso, Ba, role: CONTACT, phone: 2037377074, email: marc.grasso@yale.edu, contacts name: Kelly Cosgrove, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.30815, lon: -72.92816, hasResults: False
protocolSection identificationModule nctId: NCT06371391, orgStudyIdInfo id: 2023-02077, briefTitle: Environmental and Occupational Noise Exposure in Relation to Incidence of Type 2 Diabetes, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 1992-01-01, primaryCompletionDateStruct date: 2013-12-31, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Karolinska Institutet, class: OTHER, collaborators name: The Swedish Research Council, descriptionModule briefSummary: Large parts of the population are exposed to traffic noise, particularly in urban areas, and high noise levels occur in many workplaces. The aims of this project are to estimate exposure-response relationships for incidence of type 2 diabetes (T2D) related to long-term exposure to road traffic, railway and aircraft noise, as well as occupational noise. Furthermore, mediation by sleep disturbances and overweight/obesity is investigated, as well as interactions with air pollution and clinical biomarkers, to elucidate important etiological pathways. The project is based on pooled analyses of nine Scandinavian cohorts, totally including more than 300 000 individuals. Detailed longitudinal exposure to traffic noise from different sources, air pollutants and greenness, as well as occupational exposures, are estimated with state-of-the-art methods and supplemented with questionnaire and registry data on risk factors as well as clinical measurements. Incidence of T2D is assessed by combining information from medical examinations, high quality registers, questionnaires and biomarker measurements. Population attributable risks are estimated by combining population data on exposure with information on exposure-response relationships. In several aspects the project is unique and addresses questions which have never been studied before. Our results will provide important guidance for prioritization of preventive measures to promote health sustainable urban development and safe workplaces., conditionsModule conditions: Environment Related Disease, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 300000, type: ESTIMATED, armsInterventionsModule interventions name: No intervention, outcomesModule primaryOutcomes measure: Type 2 diabetes (T2D), eligibilityModule sex: ALL, minimumAge: 16 Years, maximumAge: 98 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06371378, orgStudyIdInfo id: gastric residual volume, briefTitle: Effect of Different Peep Values on Gastric Residual Volume, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2024-02-05, primaryCompletionDateStruct date: 2024-06-01, completionDateStruct date: 2024-09-01, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Ankara City Hospital Bilkent, class: OTHER, descriptionModule briefSummary: The aim of this study was to predict the effect of gastric antrum diameter before extubation on intra-abdominal pressure changes and consequently on the risk of pulmonary aspiration in patients undergoing elective spinal surgery under general anaesthesia in the prone position in the Neurosurgery Operating Theatre of the Ministry of Health Ankara City Hospital and to take precautions accordingly. Gastric antrum diameter and intraabdominal pressure measurements may contribute to the improvement of anaesthetic practice by reducing the risk of pulmonary aspiration and additional complications., conditionsModule conditions: Respiratory Aspiration of Gastric Content, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 90, type: ESTIMATED, armsInterventionsModule interventions name: PEEP 0, interventions name: PEEP 4, interventions name: PEEP 8, outcomesModule primaryOutcomes measure: Gastric antrum diameter, secondaryOutcomes measure: Intraabdominal pressure (IAP) measurement, secondaryOutcomes measure: gastric volume measurement, otherOutcomes measure: Vital parameters Pulse oximetry (%), otherOutcomes measure: Vital parameters systolic and diastolic blood pressure (mmHg), otherOutcomes measure: Vital parameters heart rate (beats/minute), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Ankara City Hospital, city: Ankara, state: Çankaya, country: Turkey, geoPoint lat: 39.91987, lon: 32.85427, hasResults: False
protocolSection identificationModule nctId: NCT06371365, orgStudyIdInfo id: KMUHIRB-E(II)-20220204, briefTitle: Adverse Events for Free Flap Surgery in Head and Neck Cancer, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-10-19, primaryCompletionDateStruct date: 2023-09-24, completionDateStruct date: 2023-09-24, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-18, sponsorCollaboratorsModule leadSponsor name: Kaohsiung Medical University, class: OTHER, collaborators name: Kaohsiung Medical University Chung-Ho Memorial Hospital, descriptionModule briefSummary: This is a cohort study collecting patients with head and neck cancer who underwent free flap surgery at a single medical center between January 2019 and January 2022., conditionsModule conditions: Surgical Flaps, conditions: Flap Failure Risk Factors, conditions: Hematoma Risk Factors, conditions: Thrombosis Risk Factors, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 540, type: ACTUAL, armsInterventionsModule interventions name: Free Flap surgery, outcomesModule primaryOutcomes measure: Number of participants with flap failure, secondaryOutcomes measure: Number of participants with hematoma, secondaryOutcomes measure: Number of participants with thrombosis, eligibilityModule sex: ALL, minimumAge: 20 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Kaohsiung Medical University Chung-Ho Memorial Hospital, city: Kaohsiung, country: Taiwan, geoPoint lat: 22.61626, lon: 120.31333, hasResults: False
protocolSection identificationModule nctId: NCT06371352, orgStudyIdInfo id: JagiellonianU73, briefTitle: Effect of Intermittent and Continuous Theta Burst Stimulation on Sleep, Daytime Sleepiness, and Fatigue in Depression, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2026-12, completionDateStruct date: 2027-05, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Jakub Antczak, class: OTHER, collaborators name: Institute of Psychiatry and Neurology, Warsaw, descriptionModule briefSummary: Intermittent and continuous theta-burst stimulation (iTBS and cTBS respectively) are the newer modalities of transcranial magnetic stimulation with documented efficacy in treatment of depressed mood but with conflicting results regarding their efficacy in treatment of other symptoms of depression such as insomnia, daytime sleepiness and fatigue. This study will investigate the efficacy of iTBS over the left dorsolateral prefrontal cortex (DLPFC) and cTBS over the right DLPFC, compared to sham stimulation, in treatment of insomnia, daytime sleepiness and fatigue in depression., conditionsModule conditions: Unipolar Depression, conditions: Bipolar Disorder, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Prospective, randomized, sham-controlled clinical trial in parallel design, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, maskingDescription: Placebo intervention will be delivered with a sham-coil for magnetic stimulation, which looks identical and elicits similar sounds as the coil used for active stimulation, but induces only negligible magnetic field., whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 90, type: ESTIMATED, armsInterventionsModule interventions name: iTBS, interventions name: cTBS, interventions name: Sham, outcomesModule primaryOutcomes measure: Beck Depression Inventory 2, primaryOutcomes measure: Pittsburgh Sleep Quality Index, secondaryOutcomes measure: Brief Psychiatric Rating Scale, secondaryOutcomes measure: Epworth Sleepiness Scale, secondaryOutcomes measure: Fatigue Assessment Scale, secondaryOutcomes measure: Quality of Life in Depression Scale, secondaryOutcomes measure: Sleep propensity non-rapid eye movement 1 sleep stage, secondaryOutcomes measure: Sleep propensity non-rapid eye movement 2 sleep stage, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Institute of Psychiatry and Neurology, city: Warsaw, zip: 02957, country: Poland, contacts name: Bogdan Stefanowski, role: CONTACT, phone: +48 22 45 82 532, email: bstefanowski@ipin.edu.pl, contacts name: Jakub Antczak, MD, role: CONTACT, phone: +48 12 400 25 50, email: jakub.antczak@uj.edu.pl, geoPoint lat: 52.22977, lon: 21.01178, hasResults: False
protocolSection identificationModule nctId: NCT06371339, orgStudyIdInfo id: 23 VADS 03, briefTitle: Optimization With a Gamma Camera of the Individualized Patient Dosimetry in Radioiodine Therapy of Thyroid Diseases, acronym: THIDOS, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2025-05, completionDateStruct date: 2025-06, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Institut Claudius Regaud, class: OTHER, collaborators name: Laboratoire IJCLab, descriptionModule briefSummary: This is a pilot, single-center, prospective, open-label clinical investigation of a medical device (ambulatory gamma camera " MoTI " (Mobile Therapy Imager)) for patients with hyperthyroidism (Graves' disease, toxic nodule and toxic multiheteronodular goiter) for whom 131I treatment is indicated.Its aim is to assess the feasibility of using this ambulatory gamma camera (MoTI) in the clinic in this patient population. The camera will be used to measure the 131I uptake/fixation rates during the thyroid scintigraphy.20 patients will be included in the study., conditionsModule conditions: Hyperthyroidism, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: DEVICE_FEASIBILITY, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Additional acquisitions with the investigational gamma-camera " MoTI "., outcomesModule primaryOutcomes measure: The clinical feasibility of using an ambulatory gamma camera., secondaryOutcomes measure: The level of acceptance of the gamma camera by operators for carrying out examinations, secondaryOutcomes measure: The quality of the images for the expected clinical use, secondaryOutcomes measure: The ability of the gamma camera to generate images compatible with the Picture Archiving and Communication System (PACS), secondaryOutcomes measure: The quality of the images obtained with the ambulatory gamma camera compared with those obtained during the standard examination (i.e. gamma camera used in the department, Syngula), secondaryOutcomes measure: The 131I fixation rates will be measured in percent at different times., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: IUCT-O, city: Toulouse, country: France, contacts name: Slimane ZERDOUD, role: CONTACT, phone: 05 31 15 56 28, email: zerdoud.slimane@iuct-oncopole.fr, geoPoint lat: 43.60426, lon: 1.44367, hasResults: False