protocolSection identificationModule nctId: NCT06292988, orgStudyIdInfo id: MYELO, briefTitle: Predictive Factors for Medullary Thyroid Cancer Aggressiveness, acronym: MYELO, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2024-04-15, completionDateStruct date: 2024-04-15, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Aristotle University Of Thessaloniki, class: OTHER, descriptionModule briefSummary: This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival., conditionsModule conditions: Medullary Thyroid Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 500, type: ESTIMATED, armsInterventionsModule interventions name: Total Thyroidectomy, outcomesModule primaryOutcomes measure: Central lymph node metastasis, primaryOutcomes measure: Lateral lymph node metastasis, primaryOutcomes measure: Distant metastasis, secondaryOutcomes measure: Nuclear atypia as histological predictor of aggressiveness, secondaryOutcomes measure: Amyloid as histological predictor of aggressiveness, secondaryOutcomes measure: Immunohistochemistry as histological predictor of aggressiveness, secondaryOutcomes measure: Desmoplasia as histological predictor of aggressiveness, secondaryOutcomes measure: CEA as Biochemical predictor of aggressiveness, secondaryOutcomes measure: Calcitonin as Biochemical predictor of aggressiveness, secondaryOutcomes measure: White blood cell as Biochemical predictor of aggressiveness, secondaryOutcomes measure: Platelet count as Biochemical predictor of aggressiveness, secondaryOutcomes measure: CEA drop as Biochemical cure marker, secondaryOutcomes measure: Calcitonin drop as Biochemical cure marker, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Oregon Health & Science University, Oregon, city: Oregon City, state: Oregon, zip: 97239, country: United States, contacts name: James Lim, role: CONTACT, email: ljam@ohsu.edu, geoPoint lat: 45.35734, lon: -122.60676, locations facility: Department of Surgery, Saint John of God Hospital, Salzburg, Austria, city: Salzburg, country: Austria, contacts name: Michael De Cilia, role: CONTACT, email: Michael.DeCillia@bbsalz.at, geoPoint lat: 47.79941, lon: 13.04399, locations facility: Saint Luc, University Clouvain, Belgium, city: Bruxelles, country: Belgium, contacts name: Antoine Buemi, Prof, role: CONTACT, email: antoine.buemi@saintluc.uclouvain.be, geoPoint lat: 50.85045, lon: 4.34878, locations facility: Head and Neck Surgery Department, Hospital Ana Nery, Santa Cruz do Sul, Brazil, city: Santa Cruz Do Sul, country: Brazil, contacts name: Fabio Muradas Girardi, role: CONTACT, email: fabiomgirardi@gmail.com, geoPoint lat: -29.7175, lon: -52.42583, locations facility: University Clinic of Surgery, University Hospital "Lozenec", city: Sofia, country: Bulgaria, contacts name: Rumen Pandev, role: CONTACT, email: pandevrumen@gmail.com, geoPoint lat: 42.69751, lon: 23.32415, locations facility: Chinese University of Hong Kong, city: Hong Kong, country: China, contacts name: Shirley Liu, role: CONTACT, email: liuyw@surgery.cuhk.edu.hk, geoPoint lat: 22.39407, lon: 114.13737, locations facility: Head and Neck Department Oncologos del Occidente, Universidad de Caldas, Manizales, Colombia, city: Manizales, country: Colombia, contacts name: Andres Chalas, role: CONTACT, email: andreschalag@hotmail.com, geoPoint lat: 5.06889, lon: -75.51738, locations facility: the University Hospital Center Sestre milosrdnice, Zagreb, Croatia, Department of Otorhinolaryngology and Head and Neck Surgery, city: Zagreb, country: Croatia, contacts name: Andro Kosec, Prof, role: CONTACT, email: andro.kosec@yahoo.com, geoPoint lat: 45.81444, lon: 15.97798, locations facility: Head and Neck Surgery, Brest University Hospital, Brest, France, city: Brest, country: France, contacts name: 27. Jean-Christophe Leclere, role: CONTACT, email: leclere.jean-christophe@hotmail.fr, geoPoint lat: 48.3903, lon: -4.48628, locations facility: The University Hospital of Poitiers, France, city: Poitiers, country: France, geoPoint lat: 46.58333, lon: 0.33333, locations facility: Thyroid Surgery Clinic IKE, Athens, Greece, city: Athens, country: Greece, contacts name: Stavros Karakozis, role: CONTACT, email: modernsurgery@gmail.com, contacts name: Lampros Karakozis, role: SUB_INVESTIGATOR, geoPoint lat: 37.97945, lon: 23.71622, locations facility: ENT Department University Hospital of Larissa, city: Larissa, country: Greece, contacts name: Jiannis Hajiioannou, role: CONTACT, email: jhajiioannou@gmail.com, geoPoint lat: 39.63689, lon: 22.41761, locations facility: Department of Surgery, General University Hospital of Patras, city: Patra, country: Greece, contacts name: Franko Mulita, role: CONTACT, email: oknarfmulita@hotmail.com, geoPoint lat: 38.24444, lon: 21.73444, locations facility: Aristotle University of Thessaloniki, city: Thessaloníki, country: Greece, geoPoint lat: 40.64361, lon: 22.93086, locations facility: Gennimatas General Hospital, city: Thessaloníki, country: Greece, contacts name: Ioannis Koutelidakis, role: CONTACT, email: iokoutel@gmail.com, contacts name: Nikolaos Voloudakis, role: SUB_INVESTIGATOR, geoPoint lat: 40.64361, lon: 22.93086, locations facility: Department of ENT-Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar, city: Bhubaneswar, country: India, contacts name: Kumar Parida Pradipta, role: CONTACT, email: drpradipta04@gmail.com, geoPoint lat: 20.27241, lon: 85.83385, locations facility: KMCH and KMCH Comprehensive Cancer Center, city: Coimbatore, country: India, contacts name: Manoj Dhiwakar, role: CONTACT, email: dhiwamahi@yahoo.com, geoPoint lat: 11.00555, lon: 76.96612, locations facility: Department of Endocrine and Breast Surgery at Sanjay Gandhi Post Graduate Institute of Medical Sciences, city: Madurai, country: India, contacts name: Sabaretnam Mayilvaganan, role: CONTACT, email: drretnam@gmail.com, geoPoint lat: 9.91769, lon: 78.11898, locations facility: Department of Surgery, Maulana Azad Medical College & Lok Nayak Hospital, city: New Delhi, country: India, contacts name: Lovenish Bains, role: CONTACT, email: lovenishbains@gmail.com, geoPoint lat: 28.63576, lon: 77.22445, locations facility: Endocrine and Metabolic Surgery, Bhargav Endocrine Hospital, Vijayawada, India, city: Vijayawada, country: India, contacts name: Ramakanth Bhargav Panchangam, role: CONTACT, email: endoanswers@gmail.com, geoPoint lat: 16.50745, lon: 80.6466, locations facility: University of Sulaimani | UNIVSUL ,Department of Surgery, Kurdistan, city: Erbil, country: Iraq, contacts name: Fahmi Hussein, role: CONTACT, email: fahmi.hussein@univsul.edu.iq, geoPoint lat: 36.19257, lon: 44.01062, locations facility: ASL VCO - San Biagio Hospital - Domodossola (VB) - Italy, city: Domodossola, country: Italy, contacts name: Luigi Oragano, role: CONTACT, email: luigioragano@luigioragano.com, geoPoint lat: 46.1165, lon: 8.29313, locations facility: Dipartimento di Scienze Chirurgiche (DISC), University of Genoa, Italy, city: Genoa, country: Italy, contacts name: Michele Minuto, role: CONTACT, email: micheleminuto72@gmail.com, geoPoint lat: 44.40478, lon: 8.94438, locations facility: Asst Santi Paolo e Carlo - Ospedale Polo Universitario San Paolo, Milan, Italy, city: Milan, country: Italy, contacts name: Loredana De Pasquale, role: CONTACT, email: loredana.depasquale@asst-santipaolocarlo.it, geoPoint lat: 45.46427, lon: 9.18951, locations facility: UOC Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario A Gemelli IRCCS, city: Roma, country: Italy, contacts name: Marco Raffaelli, role: CONTACT, email: Marco.Raffaelli@unicatt.it, contacts name: Francesco Pennestri, role: SUB_INVESTIGATOR, geoPoint lat: 41.89193, lon: 12.51133, locations facility: Department of Medical and Surgical Sciences, University of Trieste, Cattinara Teaching Hospital, Trieste, Italy, city: Trieste, country: Italy, contacts name: Chiara Dobrinja, role: CONTACT, email: ch_dobrinja@yahoo.it, geoPoint lat: 45.64953, lon: 13.77679, locations facility: Department of Surgery and Oncology, Endocrine Surgery Unit, Verona University Hospital, city: Verona, country: Italy, contacts name: Giacomo DiFilippo, role: CONTACT, email: giacomo.difilippo@aovr.veneto.it, geoPoint lat: 45.4299, lon: 10.98444, locations facility: Hashemite University of Zarqa, city: Zarqa, country: Jordan, contacts name: Sohail Bakkar, Prof, role: CONTACT, email: sohail.bakkar@gmail.com, geoPoint lat: 32.07275, lon: 36.08796, locations facility: Hepatobiliairy and endocrine surgery, Ibn Sina Hospital, Medical School of Medecine Rabat, Mohamed Vth University of Rabat Morocco, city: Marrakech, country: Morocco, contacts name: Omar El Malki Hadj, Prof, role: CONTACT, email: oelmalki@hotmail.com, geoPoint lat: 31.63416, lon: -7.99994, locations facility: Division of General, Endocrine and Transplant Surgery, Medical University of Gdańsk, city: Gdańsk, country: Poland, contacts name: Andrzej Hellman, Prof, role: CONTACT, email: hellmannandrzej@gumed.edu.pl, geoPoint lat: 54.35205, lon: 18.64637, locations facility: Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Medical School, University of Belgrade, city: Belgrad, country: Serbia, contacts name: Nada Santrac, role: CONTACT, email: santrac.nada@gmail.com, geoPoint lat: 44.80401, lon: 20.46513, locations facility: Comenius University in Bratislava, Department of Paediatric Surgery, National Institute of Children's Diseases, city: Bratislava, country: Slovakia, contacts name: Petra Zahradníková, Prof, role: CONTACT, email: petra.zahradnikova@nudch.eu, geoPoint lat: 48.14816, lon: 17.10674, locations facility: Department of oncological surgery, St. Elisabeth cancer Institute, city: Bratislava, country: Slovakia, contacts name: Robert Kralik, role: CONTACT, email: robert.kralik@ousa.sk, geoPoint lat: 48.14816, lon: 17.10674, locations facility: Hospital Clinic (Barcelona, Spain), city: Barcelona, country: Spain, contacts name: Aida Orois, role: CONTACT, email: aidaorois@hotmail.com, contacts name: Òscar Vidal Perez, role: SUB_INVESTIGATOR, contacts name: Marti Manyalich, role: SUB_INVESTIGATOR, geoPoint lat: 41.38879, lon: 2.15899, locations facility: Universitaria de Cordoba, city: Córdoba, country: Spain, contacts name: Constanza Ramacciotti, role: CONTACT, email: cramacciotti@hotmail.com, geoPoint lat: 37.89155, lon: -4.77275, locations facility: Hospital Regional de Málaga, city: Málaga, country: Spain, contacts name: Viyey Kishore Doulatram, role: CONTACT, email: viyu90@hotmail.es, contacts name: Marta Iturregui Guevara, role: SUB_INVESTIGATOR, geoPoint lat: 36.72016, lon: -4.42034, locations facility: Department of General and Digestive Surgery, Division of Endocrine Surgery, Complexo Hospitalario Universitario de Vigo, Vigo, Spain, city: Vigo, country: Spain, contacts name: Angel Rivo Vazaquez, role: CONTACT, email: anxorivo@yahoo.es, geoPoint lat: 42.23282, lon: -8.72264, locations facility: Bern University Hospital, city: Bern, country: Switzerland, contacts name: Reto Kaderli, Prof, role: CONTACT, email: Reto.Kaderli@insel.ch, contacts name: Nesti Cedric, role: SUB_INVESTIGATOR, geoPoint lat: 46.94809, lon: 7.44744, locations facility: Geneva University Hospital, city: Geneva, country: Switzerland, geoPoint lat: 46.20222, lon: 6.14569, locations facility: Division of Endocrinology and Metabolism Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok, Thailand, city: Bangkok, country: Thailand, contacts name: Sriphrapradang Chutintorn, role: CONTACT, email: chutins@gmail.com, geoPoint lat: 13.75398, lon: 100.50144, locations facility: Ankara University Faculty of Medicine, Department of Endocrine Surgery, city: Ankara, country: Turkey, contacts name: Volkan Cenc, role: CONTACT, email: volkangenc77@yahoo.com, geoPoint lat: 39.91987, lon: 32.85427, locations facility: Acibadem MAA University, city: Istanbul, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, locations facility: Cerrahpasa medical faculty endocrine surgery department, city: Istanbul, country: Turkey, contacts name: Selen Soylu, role: CONTACT, email: selen_soylu@yahoo.com, geoPoint lat: 41.01384, lon: 28.94966, locations facility: Department of Endocrin Pathology Unit, University of Health Sciences, Faculty of Medicine, Bakırköy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey, city: Istanbul, country: Turkey, contacts name: Altinay Serdar, role: CONTACT, email: drserdara@yahoo.com, geoPoint lat: 41.01384, lon: 28.94966, locations facility: Endocrine surgeon-consultant, International medical center "CITIDOCTOR", city: Kyiv, country: Ukraine, contacts name: Sergii Cherenko, role: CONTACT, email: sergmakar5@gmail.com, geoPoint lat: 50.45466, lon: 30.5238, locations facility: Department of Radiology, Thien Hanh Hospital, Buon Ma Thuot, Vietnam, city: Việt Trì, country: Vietnam, contacts name: Hoang Van Trung, role: CONTACT, email: dr.hoangvantrungradiology@gmail.com, geoPoint lat: 21.32274, lon: 105.40198, hasResults: False