protocolSection identificationModule nctId: NCT06327672, orgStudyIdInfo id: 162023, briefTitle: INOCA Spanish National Registry, acronym: ESP-INOCA, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-24, primaryCompletionDateStruct date: 2025-03, completionDateStruct date: 2026-03, studyFirstPostDateStruct date: 2024-03-25, lastUpdatePostDateStruct date: 2024-03-28, sponsorCollaboratorsModule leadSponsor name: Eva Rumiz González, class: OTHER, collaborators name: Hospital San Carlos, Madrid, collaborators name: Fundación de Investigación Biomédica - Hospital Universitario de La Princesa, collaborators name: Hospital Universitario Virgen de la Arrixaca, collaborators name: University Hospital Gregorio Marañón, collaborators name: Hospital Clínico Universitario de Valladolid, collaborators name: Hospital Universitario Puerta del Mar, collaborators name: Hospital Universitari de Bellvitge, collaborators name: Hospital Universitario La Fe, collaborators name: Hospital Clínico Universitario de Valencia, collaborators name: Hospital Universitario La Paz, collaborators name: Hospital General Universitario de Alicante, collaborators name: Complejo Hospitalario Universitario de Huelva, collaborators name: Hospital General Universitario de Castellón, collaborators name: Hospital de Manises, collaborators name: Hospital Clinic of Barcelona, collaborators name: Hospital Miguel Servet, collaborators name: Hospital Clínico Universitario Lozano Blesa, collaborators name: Hospital Universitario Donostia, collaborators name: Hospital General Universitario Elche, collaborators name: Hospital Universitario Virgen del Rocio, collaborators name: Hospital de la Ribera, collaborators name: Hospital de la Santa creu i Sant Pau - Barcelona, collaborators name: Hospital Virgen de la Salud, collaborators name: Hospital Universitario San Juan de Alicante, collaborators name: Hospital Universitario de Torrevieja, collaborators name: University Hospital of the Nuestra Señora de Candelaria, collaborators name: Hospital de Basurto, collaborators name: Hospital Universitario Ramon y Cajal, collaborators name: Hospital Universitario Fundación Jiménez Díaz, collaborators name: Puerta de Hierro University Hospital, collaborators name: Hospital Universitario 12 de Octubre, collaborators name: University of Salamanca, collaborators name: Hospital Universitario Marqués de Valdecilla, collaborators name: Hospital Clinico Universitario de Santiago, collaborators name: Complexo Hospitalario Universitario de A Coruña, descriptionModule briefSummary: Coronary atherosclerosis is the most common cause of ischaemic heart disease. About 40-50% of patients with symptoms and documented ischaemia on non-invasive tests do not show obstructive coronary artery disease on coronary angiography. This cause of ischaemic heart disease called INOCA (Ischemic Non-Obstructive Coronary Artery), far from having a benign prognosis, is associated with an increase in major adverse cardiac events (MACE) as well as increased functional limitation. The current European Society of Cardiology clinical practice guidelines for the management of chronic coronary syndrome establish for the first time a IIa recommendation for the invasive analysis of coronary flow reserve (CFR) and microvascular resistance index (MRI) in symptomatic patients with INOCA. The acetylcholine (Ach) test, based on intracoronary (ic) administration, is established as indication IIb for the assessment of micro or macrovascular vasospasm in patients with suspected vasospastic angina (VSA) (4). A national multicentre registry would allow us to determine the prevalence of INOCA and its different endotypes in our setting., conditionsModule conditions: Non-Obstructive Coronary Atherosclerosis, conditions: Ischemia, conditions: Coronary Disease, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 1000, type: ESTIMATED, outcomesModule primaryOutcomes measure: Prevalence of INOCA endotypes., secondaryOutcomes measure: Incidence of combined event: death from all causes, acute myocardial infarction, readmission for heart failure and consultation for chest pain in the emergency department., secondaryOutcomes measure: Targeted pharmacological treatment, secondaryOutcomes measure: Prognostic markers., secondaryOutcomes measure: INOCA and risk of heart failure with preserved ejection fraction., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hospital Universitario de la Princesa, status: RECRUITING, city: Madrid, country: Spain, contacts name: Fernando Rivero Crespo, MD, role: CONTACT, geoPoint lat: 40.4165, lon: -3.70256, locations facility: Hospital Universitario Virgen de Arrixaca, status: RECRUITING, city: Murcia, country: Spain, contacts name: Ramón Lopez Palop, MD, role: CONTACT, geoPoint lat: 37.98704, lon: -1.13004, locations facility: Hospital General Universitario de Valencia, status: RECRUITING, city: Valencia, country: Spain, contacts name: Eva Rumiz Gonzalez, MD, PhD, role: CONTACT, phone: +34 626068935, email: evarumizgonzalez@gmail.com, geoPoint lat: 39.46975, lon: -0.37739, hasResults: False