protocolSection identificationModule nctId: NCT06292156, orgStudyIdInfo id: CASPsy7, briefTitle: tACS Treatment for Cognitive Impairments in Methamphetamine Addicts, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-02-20, primaryCompletionDateStruct date: 2024-08, completionDateStruct date: 2024-08, studyFirstPostDateStruct date: 2024-03-04, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Beijing HuiLongGuan Hospital, class: OTHER, descriptionModule briefSummary: 1. To evaluate the cognitive function of methamphetamine Patients.2. Investigate the pathological mechanism of methamphetamine patients from the aspects of EEG and biology;3. The investigators investigated the effects of transcranial alternating current stimulation (tACS) on cognitive impairments in methamphetamine patients, conditionsModule conditions: Methamphetamine Abuse, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 300, type: ESTIMATED, armsInterventionsModule interventions name: Theta treatment group, interventions name: Alpha active control group, interventions name: Sham control group, outcomesModule primaryOutcomes measure: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), primaryOutcomes measure: ERP components associated with cognitive function, primaryOutcomes measure: Condition stop signal task, primaryOutcomes measure: Neural oscillations associated with cognitive function, primaryOutcomes measure: Functional connection of brain region associated with cognitive function, primaryOutcomes measure: Microstate associated with cognitive function, primaryOutcomes measure: The effect of oxidative stress system on cognitive function, primaryOutcomes measure: The effect of immune system on cognitive function, primaryOutcomes measure: The effect of brain derived neurotrophic factor(BDNF) on cognitive function, primaryOutcomes measure: Genetic mechanism of cognitive function, secondaryOutcomes measure: Reverse learning task, secondaryOutcomes measure: Beck Depression Scale, secondaryOutcomes measure: Barrett impulse Scale, secondaryOutcomes measure: Degree of insomnia, secondaryOutcomes measure: The Sensitivity to Punishment and Reward Questionnaire, secondaryOutcomes measure: Visual analog scale, secondaryOutcomes measure: The Desires for Drug Questionnaire, secondaryOutcomes measure: Obsessive compulsive drug use scale, secondaryOutcomes measure: Obsessive-compulsive inventory, secondaryOutcomes measure: Thought Control Ability Questionnaire, secondaryOutcomes measure: Thought Suppression Questionnaire, secondaryOutcomes measure: Rumination Questionnaire, secondaryOutcomes measure: Anger Rumination Questionnaire, secondaryOutcomes measure: Beck Anxiety Scale, secondaryOutcomes measure: Emotional Regulation Difficulty Scale, secondaryOutcomes measure: Aggressive questionnair, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: Xin Hua Drug Rehabilitation Center, status: RECRUITING, city: Mianyang, country: China, contacts name: China, role: CONTACT, geoPoint lat: 31.46784, lon: 104.68168, hasResults: False