protocolSection identificationModule nctId: NCT06267521, orgStudyIdInfo id: 2023-1473, secondaryIdInfos id: Protocol Version 2/8/2024, type: OTHER, domain: UW Madison, secondaryIdInfos id: L&S/PSYCHOLOGY/PSYCHOLOGY, type: OTHER, domain: UW Madison, secondaryIdInfos id: A487400, type: OTHER, domain: UW Madison, secondaryIdInfos id: AWD00000302, type: OTHER_GRANT, domain: US Department of Defense DARPA, briefTitle: The STRENGTHEN Study, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-06, primaryCompletionDateStruct date: 2025-02, completionDateStruct date: 2025-02, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: University of Wisconsin, Madison, class: OTHER, collaborators name: United States Department of Defense, descriptionModule briefSummary: This study uses two different types of interventions including electrical brain stimulation delivered during sleep, and brief, daily meditation training. The investigators are trying to figure out whether these techniques, either alone or in combination with each other, can positively impact the brain networks that support our ability to think flexibly and to regulate our emotions. 48 participants will be enrolled and can expect to be on study for up to 9 months., conditionsModule conditions: Cognitive Flexibility, conditions: Emotional Regulation, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: SINGLE, maskingDescription: Participants will not know whether they are in a group receiving active stimulation (groups 2, 3, and 4) or sham stimulation (group 1). However, participants will know whether they are performing meditation (groups 1, 3, and 4) or listening to only the didactic meditation material (group 2), and participants will be aware of how many nights they are undergoing stimulation (1 night per week for group 3, 2 nights per week for groups 1, 2, and 4). Thus, participants will be only partially blind to condition. Investigators will not be blind to condition., whoMasked: PARTICIPANT, enrollmentInfo count: 48, type: ESTIMATED, armsInterventionsModule interventions name: Healthy Minds Program, interventions name: Sham Meditation Didactic Material, interventions name: Sham Stimulation in Lab, interventions name: Stimulation in Lab, interventions name: MRI Scanner, outcomesModule primaryOutcomes measure: Change in Patient Health Questionnaire-9 (PHQ-9) Score, primaryOutcomes measure: Change in General Anxiety Disorder (GAD-7) Score, primaryOutcomes measure: Change in Single-item Suicide Question, primaryOutcomes measure: Change in Healthy Minds Index (HM Index), primaryOutcomes measure: Change in the Perceived Stress Scale (PSS) Score, primaryOutcomes measure: Change in Emotional Styles Questionnaire (ESQ) Score, primaryOutcomes measure: Change in Cognitive Flexibility Inventory (CFI) Score: Alternatives Subscale, primaryOutcomes measure: Change in Cognitive Flexibility Inventory (CFI) Score: Control Subscale, primaryOutcomes measure: Change in Difficulties in Emotion Regulation Scale-18 (DERS-18) Score, primaryOutcomes measure: Change in PROMIS Sleep Disturbance Score, primaryOutcomes measure: Change in PTSD Checklist for DSM-5 (PCL-5), primaryOutcomes measure: Change in World Health Organization-5 (WHO-5), primaryOutcomes measure: Change in Restorative Sleep Questionnaire (RSQ) Score, primaryOutcomes measure: Change in Sleep Depth Question (SDQ) Score, primaryOutcomes measure: Change in Pittsburgh Sleep Quality Index (PSQI) Score, primaryOutcomes measure: Change in Suicide Risk Survey, primaryOutcomes measure: Change in Brief Suicide Cognitions Scale (B-SCS) Score, primaryOutcomes measure: Change in Passive and Active Suicidal Ideation Scale (PASIS) Score, primaryOutcomes measure: Change in NIH Toolbox Loneliness Score, primaryOutcomes measure: Change in Five Facet Mindfulness Questionnaire (FFMQ) Score, primaryOutcomes measure: Change in Drexel Defusion Scale (DDS) Score, primaryOutcomes measure: Change in PROMIS Meaning and Purpose Score, primaryOutcomes measure: Change in Digital Working Alliance Inventory (D-WAI) Score, primaryOutcomes measure: Change in Perseverative Thinking Questionnaire (PTQ) Score, primaryOutcomes measure: Change in Experiences Questionnaire's Decentering subscale (EQ-D) Score, primaryOutcomes measure: Change in Experience Sampling / Ecological Momentary Assessment, primaryOutcomes measure: Change in Death Implicit Association Test Score, primaryOutcomes measure: Change in Reversal Learning Task Score, primaryOutcomes measure: Change in Multi-Source Interference Task Score, primaryOutcomes measure: Change in Emotional Stroop Score: Reaction Time, primaryOutcomes measure: Change in Emotional Stroop Score: Percent Correct, primaryOutcomes measure: Change in Meteor Mission Score: Mean Reaction Time, primaryOutcomes measure: Change in Meteor Mission Score: Coefficient of Variation, primaryOutcomes measure: Change in Meteor Mission Score: Percent Correct, primaryOutcomes measure: Change in Emotional Persistence Task Score, primaryOutcomes measure: Change in Change Your Mind Task Score: Mean Change, primaryOutcomes measure: Change in Change Your Mind Task Score: Accuracy, primaryOutcomes measure: Change in Change Your Mind Task Score: Response Time, secondaryOutcomes measure: Change in Spectral Power Density During Stimulation-Free Sleep, secondaryOutcomes measure: Resting-state fMRI Connectivity Z-Scores, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: Center for Healthy Minds, status: RECRUITING, city: Madison, state: Wisconsin, zip: 53703, country: United States, geoPoint lat: 43.07305, lon: -89.40123, hasResults: False