protocolSection identificationModule nctId: NCT06288828, orgStudyIdInfo id: IRB0569/66, briefTitle: The Efficacy of Aerobic Exercise Training on Autonomic Nervous System and Endothelial Function in Patients With Compensated Cirrhosis, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-05, primaryCompletionDateStruct date: 2024-08-01, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-03-01, sponsorCollaboratorsModule leadSponsor name: King Chulalongkorn Memorial Hospital, class: OTHER, collaborators name: Chulalongkorn University, descriptionModule briefSummary: The goal of this clinical trial is to explore the impact of a 16-week aerobic exercise regimen on the autonomic nervous system and endothelial function in patients with compensated cirrhosis who maintain sedentary lifestyles. The primary research question is:1) What effect does 16 weeks of aerobic exercise have on changes in the autonomic nervous system and endothelial function in cirrhotic patients?Additionally, the secondary research questions are:1. How does a 16-week aerobic exercise program influence changes in muscle mass, muscle strength, and physical performance in cirrhotic patients?2. Is there a correlation between muscle mass and parameters of the autonomic nervous system in cirrhotic patients?Participants in the intervention group will undergo 150 minutes of moderate aerobic exercise per week for 16 weeks, accompanied by a personalized nutritional plan (1.2 grams of protein per kilogram of ideal body weight per day and a calorie intake of 35 kilocalories per kilogram of ideal body weight per day). The control group will solely receive nutritional guidance and maintain their sedentary lifestyle. The researchers will compare outcomes between these two groups., conditionsModule conditions: Cirrhosis, conditions: Aerobic Exercises, conditions: Lifestyle Modification, conditions: Endothelial Function, conditions: Autonomic Nervous System, conditions: Autonomic Dysfunction, conditions: Heart Rate Variability, conditions: Flow Mediated Dilation, conditions: Sarcopenia, conditions: Physical Activity, conditions: Physical Functional Performance, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: INVESTIGATOR, enrollmentInfo count: 70, type: ESTIMATED, armsInterventionsModule interventions name: Aerobic exercise, interventions name: Nutrition consultant, outcomesModule primaryOutcomes measure: Autonomic function test: Heart rate variability (HRV), primaryOutcomes measure: Endothelial function test: Flow mediated dilation (FMD) in % FMD change, secondaryOutcomes measure: Physical function, secondaryOutcomes measure: Muscle mass change, secondaryOutcomes measure: Muscle strength change, eligibilityModule sex: ALL, minimumAge: 45 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Faculty of medicine, King Chulalongkorn Memorial Hospital, city: Bangkok, zip: 10330, country: Thailand, geoPoint lat: 13.75398, lon: 100.50144, hasResults: False