hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06388031, orgStudyIdInfo id: CAPTRAL2024v1, briefTitle: ICI Rechallenge for Advanced NSCLC With Long-Term Response to First-Line ICI, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-10, primaryCompletionDateStruct date: 2027-01-10, completionDateStruct date: 2027-12-10, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: Peking Union Medical College Hospital, class: OTHER, descriptionModule briefSummary: An exploratory phase II trial of immune checkpoint inhibitors (ICIs, anti-PD-1/anti-PD-L1) as second-line treatment with advanced non-small cell lung cancer (NSCLC) who had long-term response to first-line immunotherapy (with or without chemotherapy).This study aims to evaluate efficacy and safety of ICI rechallenge in long-term responders to prior ICI. Furthermore, it seeks to identify biomarkers capable of predicting the efficacy of immunotherapy and prognosis., conditionsModule conditions: Non-small Cell Lung Cancer, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 27, type: ESTIMATED, armsInterventionsModule interventions name: Immune checkpoint inhibitor, outcomesModule primaryOutcomes measure: Progression Free Survival (PFS), secondaryOutcomes measure: Overall Survival (OS), secondaryOutcomes measure: Objective Response Rate (ORR), secondaryOutcomes measure: Progression Free Survival 2 (PFS 2), otherOutcomes measure: Safety profile, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Peking Union Medical College Hospital, city: Beijing, zip: 100730, country: China, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False
protocolSection identificationModule nctId: NCT06388018, orgStudyIdInfo id: NRG-GY032, secondaryIdInfos id: NCI-2023-09355, type: REGISTRY, domain: CTRP, secondaryIdInfos id: CCTG EN.10, type: OTHER, domain: CCTG, secondaryIdInfos id: U10CA180868, type: NIH, link: https://reporter.nih.gov/quickSearch/U10CA180868, briefTitle: Tailoring Therapy in Post-surgical Patients With Low-risk Endometrial Cancer, statusModule overallStatus: SUSPENDED, startDateStruct date: 2024-04-16, primaryCompletionDateStruct date: 2025-01-09, completionDateStruct date: 2025-01-09, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: NRG Oncology, class: OTHER, collaborators name: National Cancer Institute (NCI), collaborators name: Canadian Cancer Trials Group, descriptionModule briefSummary: This phase II trial tests how well tailoring therapy in post-surgery works in patients with low-risk endometrial cancer. The usual approach for patients with low-risk endometrial cancer is treatment with surgery. In this study, tissue that is removed as part of the surgical procedure is analyzed in the pathology laboratory to help guide the doctor to decide whether or not additional treatment such as radiation and or chemotherapy should be recommended., conditionsModule conditions: Stage I Uterine Corpus Endometrial Stromal Sarcoma AJCC V8, conditions: Stage II Uterine Corpus Endometrial Stromal Sarcoma AJCC V8, conditions: Stage III Uterine Corpus Endometrial Stromal Sarcoma AJCC V8, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 325, type: ESTIMATED, armsInterventionsModule interventions name: Clinical Observation, interventions name: External Beam Radiation Therapy, interventions name: High-Dose-Rate Vaginal Brachytherapy, interventions name: Computed Tomography, interventions name: Positron Emission Tomography, interventions name: X-Ray Imaging, interventions name: Magnetic Resonance Imaging, interventions name: Questionnaire Administration, outcomesModule primaryOutcomes measure: Time to pelvic recurrence, secondaryOutcomes measure: Time to isolated vaginal recurrence, secondaryOutcomes measure: Recurrence-free survival, secondaryOutcomes measure: Endometrial cancer-specific survival, secondaryOutcomes measure: Fear of recurrence, eligibilityModule sex: FEMALE, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Washington University School of Medicine, city: Saint Louis, state: Missouri, zip: 63110, country: United States, geoPoint lat: 38.62727, lon: -90.19789, hasResults: False
protocolSection identificationModule nctId: NCT06387992, orgStudyIdInfo id: PP24023, briefTitle: Evaluation of the Agreement Between a Consultation With a Nurse Acquiring Three-dimensional Intraoral Images Made With a 3D Intraoral Camera and the Standard Consultation With a Dental Surgeon, in Institutionalized Elderly Subjects, acronym: GEROdonto3D, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-01, primaryCompletionDateStruct date: 2027-06-01, completionDateStruct date: 2027-06, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: CHU de Reims, class: OTHER, descriptionModule briefSummary: The primary objective of this study will be to assess the agreement between a dental consultation with a nurse acquiring intraoral images, using a 3D intraoral camera, and a standard consultation with a dental surgeon, in institutionalized elderly subjects Institutionalized subjects planned to have a dental consultation and eligible will be included once written informed consent is signed. Their dental consultation will start with a consultation with a nurse to record 3D intraoral images, then a consultation with a dental surgeon for standard dental care, blinded from the nurse consultation will be performed. Thereafter, 3D images will be analyzed by another dental surgeon blinded from the results of both consultations. Agreement on different outcomes between the analysis of the images acquired by the nurse and the standard dental evaluation by a dental surgeon will be assessed.Agreement on the results between the interpretation of the 3D images acquired by a nurse and the standard consultation by a dental surgeon could lead, in the long term, to a significant step forward in dental care of institutionalized patients.Indeed, training nursing home nurses to acquire 3D dental images would enable the identification of patients in need of immediate dental care and thus extend the possibilities of access to consultations with a dentist for these patients. This would increase the efficiency of care., conditionsModule conditions: Dental Care for Institutionalized Elderly Persons, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Three-dimensional dental acquisition, outcomesModule primaryOutcomes measure: DMFT index, secondaryOutcomes measure: Plaque control record, secondaryOutcomes measure: General Oral Health Assessment Index (GOHAI), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Damien JOLLY, city: Reims, country: France, contacts name: Carole ETIENNOT, role: CONTACT, phone: 03 10 73 66 79, phoneExt: 0033, email: cetiennot@chu-reims.fr, geoPoint lat: 49.25, lon: 4.03333, hasResults: False
protocolSection identificationModule nctId: NCT06387979, orgStudyIdInfo id: 19-010725, secondaryIdInfos id: NCI-2024-01000, type: REGISTRY, domain: CTRP (Clinical Trial Reporting Program), secondaryIdInfos id: 19-010725, type: OTHER, domain: Mayo Clinic in Florida, secondaryIdInfos id: P30CA015083, type: NIH, link: https://reporter.nih.gov/quickSearch/P30CA015083, secondaryIdInfos id: R33CA240181, type: NIH, link: https://reporter.nih.gov/quickSearch/R33CA240181, briefTitle: Advanced Development of Desorption Electrospray Ionization Mass Spectrometry for Intraoperative Molecular Diagnosis of Brain Cancer Using Pathology Biopsies, statusModule overallStatus: RECRUITING, startDateStruct date: 2020-10-26, primaryCompletionDateStruct date: 2025-10-15, completionDateStruct date: 2025-10-15, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: Mayo Clinic, class: OTHER, collaborators name: National Cancer Institute (NCI), descriptionModule briefSummary: This study explores whether DESI-MS can be used to identify cancerous vs. noncancerous tissue during brain tumor surgery., conditionsModule conditions: Glioma, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 185, type: ESTIMATED, armsInterventionsModule interventions name: Non-Interventional Study, outcomesModule primaryOutcomes measure: Pathological state of the tissue, primaryOutcomes measure: Percentage of tumor infiltration, primaryOutcomes measure: Presence of IDH mutations, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Mayo Clinic in Florida, status: RECRUITING, city: Jacksonville, state: Florida, zip: 32224-9980, country: United States, contacts name: Clinical Trials Referral Office, role: CONTACT, phone: 855-776-0015, email: mayocliniccancerstudies@mayo.edu, contacts name: Alfredo Quinones-Hinojosa, M.D., role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.33218, lon: -81.65565, hasResults: False
protocolSection identificationModule nctId: NCT06387966, orgStudyIdInfo id: H-FNTN-PI-Ia, briefTitle: A Randomized, Double-blind,Dose-escalating, Single-dose, Oral Phase I Clinical Study of Flunotinib Healthy People, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-29, primaryCompletionDateStruct date: 2024-08-29, completionDateStruct date: 2024-12-30, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: Chengdu Zenitar Biomedical Technology Co., Ltd, class: INDUSTRY, descriptionModule briefSummary: Evaluate the safety and tolerability of a single increasing dose of Flibanserin Maleate tablets administered orally to healthy adult Chinese subjects; preliminarily assess the pharmacokinetic characteristics of a single dose of oral Flibanserin Maleate tablets, conditionsModule conditions: Healthy Person, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: flunotinib, interventions name: flunotinib placebo, outcomesModule primaryOutcomes measure: Prilinostat Mesylate Pharmacokinetics (PK)：Cmax, primaryOutcomes measure: Prilinostat Mesylate Pharmacokinetics (PK)：Tmax, primaryOutcomes measure: The statistical parameters of fecal pharmacokinetics are the cumulative excretion of prototype drugs and major metabolites in feces (Ae0-144h) and excretion rate (Ae%);, primaryOutcomes measure: Prilinostat Mesylate Pharmacokinetics (PK)：AUC0-∞, primaryOutcomes measure: Prilinostat Mesylate Pharmacokinetics (PK)：MRT, primaryOutcomes measure: Prilinostat Mesylate Pharmacokinetics (PK)：Vd, primaryOutcomes measure: Prilinostat Mesylate Pharmacokinetics (PK)：t1/2, primaryOutcomes measure: Prilinostat Mesylate Pharmacokinetics (PK)：CLz/F, primaryOutcomes measure: Prilinostat Mesylate Pharmacokinetics (PK)：Vz/F, primaryOutcomes measure: Prilinostat Mesylate Pharmacokinetics (PK)：Ke, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: Chengdu Xinhua Hospital, status: RECRUITING, city: Chengdu, state: Sichuan, zip: 610000, country: China, contacts name: Xiaolan Yong, bachelor, role: CONTACT, phone: 13568843829, email: yongxlan@126.com, geoPoint lat: 30.66667, lon: 104.06667, hasResults: False
protocolSection identificationModule nctId: NCT06387953, orgStudyIdInfo id: STUDY00019480, briefTitle: Mitigation of Emergence Agitation Through Implementation of Masimo Bridge Therapy, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2025-06, completionDateStruct date: 2025-06, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: University of Washington, class: OTHER, descriptionModule briefSummary: This is a randomized, prospective, double-blinded (patient and outcome-assessor) trial. Our goal is to assess efficacy of Bridge Therapy (versus sham bridge therapy) to prevent emergence agitation following general anesthesia.Primary Objective: Activation of Bridge Therapy from the time of the pre incision "time out" until 24 hours after admission to the PACU (Post Anesthesia Care Unit) is associated with reduced frequency and intensity of emergence agitation.Secondary Objective: Bridge Therapy activation will also result in a lower incidence of rescue pharmacologic treatment of agitation.Tertiary Objective: Activation of Bridge Therapy during a stable anesthetic state is associated with a reduced Patient State Index as measured on Sedline, conditionsModule conditions: Emergence Delirium, conditions: Agitation, Emergence, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Bridge Therapy, interventions name: Sham Therapy, outcomesModule primaryOutcomes measure: Emergence agitation, primaryOutcomes measure: Emergence agitation, secondaryOutcomes measure: Rescue pharmacologic treatment of agitation, otherOutcomes measure: Patient State Index, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06387940, orgStudyIdInfo id: UEC 2019 008 FHMS, briefTitle: Acute Metabolic Effects of Carbohydrate Restriction at Varying Energy Levels, statusModule overallStatus: COMPLETED, startDateStruct date: 2019-11-05, primaryCompletionDateStruct date: 2020-04-01, completionDateStruct date: 2022-11-20, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: University of Surrey, class: OTHER, descriptionModule briefSummary: This study investigates how different low-carbohydrate diets affect metabolism and hunger in overweight adults. We will measure metabolic rates and blood metabolites., conditionsModule conditions: Healthy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 12, type: ACTUAL, armsInterventionsModule interventions name: nEB Diet, followed for 36 hours, interventions name: LC25 Diet, followed for 36 hours, interventions name: LCEB Diet, followed for 36 hours, outcomesModule primaryOutcomes measure: Biomarkers in blood Measured, primaryOutcomes measure: Resting metabolic rate, secondaryOutcomes measure: Perceived Appetite Scores, secondaryOutcomes measure: Food intake, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Surrey, city: Guildford, zip: GU2 7XH, country: United Kingdom, geoPoint lat: 51.23536, lon: -0.57427, hasResults: False
protocolSection identificationModule nctId: NCT06387927, orgStudyIdInfo id: PT-NEUR-10/2023-520, briefTitle: Effect of Home-exercise Programs Versus Supervised Core Stability Exercises on Hypertensive Patient With Low Back Pain, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-09-02, primaryCompletionDateStruct date: 2024-02-02, completionDateStruct date: 2024-02-20, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: Ahram Canadian University, class: OTHER, descriptionModule briefSummary: Thirty male and female hypertension patients with chronic mechanical non-specific low back pain were included in this randomized controlled study conducted at the Ababa Private Physical Therapy Center in Beni-Seuf, Egypt. They were randomly assigned into two equal groups; the study group A control (n = 15) had a supervised conventional core stability, while the study group B (n = 15) received a home exercise program. In both groups' patients had evaluations before and after their six-week course of therapy. Modified-modified Schober test was used to assess the active back range of motion (ROM), Arabic version of Oswestry disability index (ODI) was utilized to evaluate functional disability, and visual analog scale (VAS) was used to measure pain., conditionsModule conditions: Hypertension, conditions: Low Back Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, enrollmentInfo count: 30, type: ACTUAL, armsInterventionsModule interventions name: home exercise program, interventions name: the core stability exercise, outcomesModule primaryOutcomes measure: Assessment of pain, primaryOutcomes measure: Assessment of lumbar flexion range of motion, primaryOutcomes measure: Assessment of functional disability, eligibilityModule sex: ALL, minimumAge: 30 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: Faculty of physical therapy, city: Giza, zip: 3387722, country: Egypt, geoPoint lat: 30.00808, lon: 31.21093, hasResults: False
protocolSection identificationModule nctId: NCT06387888, orgStudyIdInfo id: E-31034136-302.08.01-4221, briefTitle: The Effect of Mother's Voice on the Levels of Pain and Comfort in Newborns, acronym: Newborn, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-07-01, primaryCompletionDateStruct date: 2021-09-01, completionDateStruct date: 2022-04-30, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: Istanbul Medipol University Hospital, class: OTHER, descriptionModule briefSummary: This study was conducted in a randomized controlled experimental type to determine the effect of maternal voice during care on pain and comfort level in term newborns receiving mechanical ventilation. The sample of the study was consisted of 60 term newborns receiving mechanical ventilation who were hospitalized in the 7-bed Neonatal Intensive Care Unit of a private hospital in Istanbul in accordance with the selection criteria. Introductory Information Form, Vital Signs Follow-up Form, Neonatal Comfort Behavior Scale and Neonatal Pain Scale (NPASS) forms prepared by the researchers were used as data collection tools., conditionsModule conditions: Newborns, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, whoMasked: INVESTIGATOR, enrollmentInfo count: 60, type: ACTUAL, armsInterventionsModule interventions name: Listening to mother's voice, outcomesModule primaryOutcomes measure: Neonatal Comfort Behavior Scale, secondaryOutcomes measure: Neonatal Comfort Behavior Scale (COMFORTneo):, eligibilityModule sex: ALL, minimumAge: 3 Weeks, maximumAge: 41 Weeks, stdAges: CHILD, contactsLocationsModule locations facility: Istanbul Medipol University Hospital, city: Istanbul, state: Beykoz, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06387875, orgStudyIdInfo id: Hangzhou Bay Cohort, briefTitle: Cohort in Qianwan New District, Ningbo, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-01, primaryCompletionDateStruct date: 2027-06-30, completionDateStruct date: 2027-06-30, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: RenJi Hospital, class: OTHER, collaborators name: Ningbo Hangzhou Bay Hospital, descriptionModule briefSummary: Our objective is to carry out research on prevention and control of noncommunicable chronic diseases, and establish a risk prediction mechanism for chronic diseases to promote early detection, early diagnosis and early treatment of chronic diseases in natural population in Qianwan District of Ningbo, significantly reduce medical costs and extend population life span., conditionsModule conditions: Cardiovascular Diseases, conditions: Stroke, conditions: Non-Communicable Chronic Diseases, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 30000, type: ESTIMATED, outcomesModule primaryOutcomes measure: death, primaryOutcomes measure: incidence of cardio-cerebrovascular diseases, primaryOutcomes measure: incidence of other non-communicable chronic diseases, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Ren Ji Hospital Afflited to School of Medicine, Shanghai Jiao Tong University, status: RECRUITING, city: Shanghai, country: China, contacts name: Jun Pu, MD,PHD, role: CONTACT, phone: 86-21-68383477, email: pujun310@hotmail.com, geoPoint lat: 31.22222, lon: 121.45806, hasResults: False