hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06343480, orgStudyIdInfo id: SMVOT2024CT, briefTitle: Misoprostol Versus Oxytocin for Induction of Labour in Parturients With Spontaneous Rupture of Fetal Membranes at Term, statusModule overallStatus: COMPLETED, startDateStruct date: 2020-09-01, primaryCompletionDateStruct date: 2021-08-31, completionDateStruct date: 2021-11-30, studyFirstPostDateStruct date: 2024-04-02, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Federal Teaching Hospital Abakaliki, class: OTHER_GOV, descriptionModule briefSummary: Intravenous oxytocin titration has a prime position as a choice agent for induction of labour following term PROM as it has been shown to be efficacious for such purpose. Recent evidence however has shown that misoprostol is associated with better outcomes and merits evaluation in our environment. This study compared the efficacy of misoprostol and oxytocin for induction of labour in parturients with term Prelabour Ruptuture of Membranes., conditionsModule conditions: Labor Onset and Length Abnormalities, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, enrollmentInfo count: 120, type: ACTUAL, armsInterventionsModule interventions name: Labour Induction, outcomesModule primaryOutcomes measure: Mean induction delivery interval, eligibilityModule sex: FEMALE, minimumAge: 15 Years, maximumAge: 44 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Alex Ekwueme Federal University Teaching Hospital, city: Abakaliki, state: Ebonyi, zip: 480001, country: Nigeria, geoPoint lat: 6.32485, lon: 8.11368, locations facility: Federal Teaching Hospital, Abakaliki, city: Abakaliki, state: Ebonyi, zip: 480001, country: Nigeria, geoPoint lat: 6.32485, lon: 8.11368, hasResults: False
protocolSection identificationModule nctId: NCT06343467, orgStudyIdInfo id: A17-376, briefTitle: Do Generic Volar Locking Plates Provide Similar Outcomes at a Reduced Cost?, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-11-01, primaryCompletionDateStruct date: 2023-04-30, completionDateStruct date: 2023-04-30, studyFirstPostDateStruct date: 2024-04-02, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: HealthPartners Institute, class: OTHER, descriptionModule briefSummary: Across orthopedics, the investigators will be using the generic volar locking plates for patients undergoing open reduction and internal fixation (ORIF) of the distal radius using a block schedule, meaning one month we the generic implants and one month we use conventional implants from the surgeon's brand of choice. At the end of each month the health system will switch which type of implants (generic vs. conventional) they will use at their facilities. From a quality perspective each patient will be monitored both short and long term for complication and reoperation. This will be done through chart review., conditionsModule conditions: Distal Radius Fractures, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Surgeons alternated between using generic implants and conventional implants in their distal radius fracture patients over the course of six months., primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: Patients underwent the standard surgical consent, however the specific plate vendor that was used, was not specified by the physician., whoMasked: PARTICIPANT, enrollmentInfo count: 101, type: ACTUAL, armsInterventionsModule interventions name: Generic Volar Locking Plate, interventions name: Conventional Volar Locking Plate, outcomesModule primaryOutcomes measure: 90-day reoperation rate, primaryOutcomes measure: 90-day readmission rate, primaryOutcomes measure: 90-day mortality rate, secondaryOutcomes measure: Implant Cost, secondaryOutcomes measure: Tourniquet Time, secondaryOutcomes measure: Estimated Blood Loss, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Regions Hospital, city: Saint Paul, state: Minnesota, zip: 55101, country: United States, geoPoint lat: 44.94441, lon: -93.09327, documentSection largeDocumentModule largeDocs typeAbbrev: Prot_SAP, hasProtocol: True, hasSap: True, hasIcf: False, label: Study Protocol and Statistical Analysis Plan, date: 2022-08-16, uploadDate: 2024-03-14T00:31, filename: Prot_SAP_000.pdf, size: 218626, hasResults: False
protocolSection identificationModule nctId: NCT06343454, orgStudyIdInfo id: 2023/04-03(KA-22111), briefTitle: The Effect of Different Head Positions on Occlusal Contacts During Digital Interocclusal Bite Registration, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-10-25, primaryCompletionDateStruct date: 2024-01-27, completionDateStruct date: 2024-03-03, studyFirstPostDateStruct date: 2024-04-02, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Hacettepe University, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to learn about different head position's effect on occlusal contacts during digital interocclusal record. The main question aims to answer is:• Are different head positions in physiological limits can be affected the occlusal contact during interocclusal record? Participants will be asked to stand in three different physiological head positions (neutral, forward and backward) which are common in daily routine. In these positions, after maxillary and mandibular arch scans three different interocclusal records will be taken. Also for assessment of these records in digital occlusal analysis module (oJMA, zebras), three different oJMA record will be taken.Researchers will compare neutral, forward and backward head positions to see if there are any difference in number, density and location of occlusal contacts., conditionsModule conditions: Occlusion, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: DIAGNOSTIC, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 36, type: ACTUAL, armsInterventionsModule interventions name: Digital Interocclusal Record In Different Head Positions, outcomesModule primaryOutcomes measure: Number of Occlusal Contacts, primaryOutcomes measure: Density of Occlusal Contacts, primaryOutcomes measure: Location of Occlusal Contacts, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hacettepe University, city: Ankara, country: Turkey, geoPoint lat: 39.91987, lon: 32.85427, documentSection largeDocumentModule largeDocs typeAbbrev: Prot_SAP, hasProtocol: True, hasSap: True, hasIcf: False, label: Study Protocol and Statistical Analysis Plan, date: 2023-04-17, uploadDate: 2024-03-29T04:39, filename: Prot_SAP_000.pdf, size: 212403, largeDocs typeAbbrev: ICF, hasProtocol: False, hasSap: False, hasIcf: True, label: Informed Consent Form, date: 2023-04-17, uploadDate: 2024-03-29T04:39, filename: ICF_001.pdf, size: 97067, hasResults: False
protocolSection identificationModule nctId: NCT06343441, orgStudyIdInfo id: SH9H-2024-T29-2, briefTitle: Accuracy of Two Methods of Making Impressions for Complete-arch Implant Supported Fixed Prosthesis, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-31, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-04-02, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, class: OTHER, descriptionModule briefSummary: To compare the accuracy of digital impression and conventional impression for complete-arch implant-supported fixed prosthesis, conditionsModule conditions: Edentulous Jaw, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 22, type: ESTIMATED, armsInterventionsModule interventions name: intraoral scan, interventions name: open tray impression, outcomesModule primaryOutcomes measure: Grade of framework passive fit, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06343428, orgStudyIdInfo id: IEO 1519, briefTitle: Definition of a Multiparametric Prognostic and Predictive System of Classification of NET G3 Patients, acronym: TAPIOCA, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-07-19, primaryCompletionDateStruct date: 2024-07-19, completionDateStruct date: 2026-07-19, studyFirstPostDateStruct date: 2024-04-02, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: European Institute of Oncology, class: OTHER, descriptionModule briefSummary: The 2017 World Health Organization (WHO) introduced a new category of high-grade, well-differentiated neuroendocrine neoplasms (NENs) that called neuroendocrine tumors (NETs) G3 in pancreatic NENs classification and, then, in 2019, for all gastro-entero-pancreatic (GEP) tract NENs.The new classification made it possible to separate NETs G3 from high-grade, poorly-differentiated, NENs that are called neuroendocrine carcinomas (NECs).However, in clinical practice, we observed that several clinical, pathological and radiological differences are arising among NET G3 patients, suggesting that a multiparametric definition of NET G3 is needed., conditionsModule conditions: Neuroendocrine Neoplasm, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Immunohistochemical characteristics analysis, secondaryOutcomes measure: Review of the functional imaging, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: European Institute of Oncology, status: RECRUITING, city: Milan, zip: 20141, country: Italy, contacts name: Francesca Spada, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.46427, lon: 9.18951, hasResults: False
protocolSection identificationModule nctId: NCT06343402, orgStudyIdInfo id: TBBO8520-101, secondaryIdInfos id: ONKORAS-101, type: OTHER, domain: TheRas, briefTitle: Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2027-08, completionDateStruct date: 2028-02, studyFirstPostDateStruct date: 2024-04-02, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: TheRas, Inc, class: INDUSTRY, descriptionModule briefSummary: A first in human study to evaluate the safety, tolerability, and pharmacokinetics (PK) of BBO-8520, a KRAS G12C (ON) inhibitor, single agent and in combination with pembrolizumab in patients with advanced non-small cell lung cancer, conditionsModule conditions: Non-small Cell Lung Cancer, conditions: Metastatic Non-Small Cell Lung Cancer, conditions: NSCLC, conditions: KRAS G12C, conditions: Metastatic Lung Cancer, conditions: Advanced Lung Carcinoma, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NON_RANDOMIZED, interventionModel: SEQUENTIAL, interventionModelDescription: Phase 1a: sequential/parallel, Phase 1b: parallel, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 160, type: ESTIMATED, armsInterventionsModule interventions name: BBO-8520, interventions name: Pembrolizumab, outcomesModule primaryOutcomes measure: Adverse Events, primaryOutcomes measure: Dose-limiting toxicities (DLTs), secondaryOutcomes measure: To evaluate preliminary antitumor activity of BBO-8520, secondaryOutcomes measure: To evaluate preliminary antitumor activity of BBO-8520, secondaryOutcomes measure: Overall Survival (OS), secondaryOutcomes measure: To characterize the pharmacokinetics (PK) of BBO-8520, secondaryOutcomes measure: To characterize the pharmacokinetics (PK) of BBO-8520, secondaryOutcomes measure: To characterize the pharmacokinetics (PK) of BBO-8520, secondaryOutcomes measure: To characterize the pharmacokinetics (PK) of BBO-8520, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Cleveland Clinic, status: RECRUITING, city: Cleveland, state: Ohio, zip: 44195, country: United States, geoPoint lat: 41.4995, lon: -81.69541, locations facility: SCRI Oncology Partners, status: RECRUITING, city: Nashville, state: Tennessee, zip: 37203, country: United States, geoPoint lat: 36.16589, lon: -86.78444, locations facility: NEXT Oncology, status: RECRUITING, city: Fairfax, state: Virginia, zip: 22031, country: United States, geoPoint lat: 38.84622, lon: -77.30637, locations facility: Peter MacCallum Cancer Centre, status: RECRUITING, city: Melbourne, state: Victoria, zip: 3051, country: Australia, geoPoint lat: -37.814, lon: 144.96332, hasResults: False
protocolSection identificationModule nctId: NCT06343389, orgStudyIdInfo id: Soh-Med-24-03-14MS, briefTitle: Acute Kidney Injury in Patients With Liver Cirrhosis, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2024-10, completionDateStruct date: 2025-04, studyFirstPostDateStruct date: 2024-04-02, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Sohag University, class: OTHER, descriptionModule briefSummary: In our locality, limited studies have discussed AKI in patients with liver cirrhosis and its outcome, therefore we aim to highlight the incidence, patterns, risk factors, and outcomes of acute kidney injury in patients with liver cirrhosis at Sohag University Hospital., conditionsModule conditions: Acute Kidney Injury in Patients With Liver Cirrhosis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 200, type: ESTIMATED, armsInterventionsModule interventions name: serum creatinine, outcomesModule primaryOutcomes measure: Incidence of acute kidney injury in cirrhotic patients in Sohag University Hospital, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Sohag University Hospital, status: RECRUITING, city: Sohag, country: Egypt, contacts name: Magdy M Amin, professor, role: CONTACT, geoPoint lat: 26.55695, lon: 31.69478, hasResults: False
protocolSection identificationModule nctId: NCT06343363, orgStudyIdInfo id: 318352, briefTitle: Early Discharge After Mitral and Tricuspid Edge-to-edge Repair: an Assessment of Feasibility and Safety, acronym: EARLY-Edge, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-05-01, primaryCompletionDateStruct date: 2025-05, completionDateStruct date: 2025-12, studyFirstPostDateStruct date: 2024-04-02, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Oxford University Hospitals NHS Trust, class: OTHER, collaborators name: Edwards Lifesciences, descriptionModule briefSummary: Mitral regurgitation (MR) and tricuspid regurgitation (TR) are common causes of breathlessness, fluid retention and other heart failure symptoms, which lead to reduced quality of life and frequent hospitalisation. These conditions are particularly prevalent in older adults with many of these patients being at high risk for surgical intervention due to frailty and comorbidities, leaving them with few treatment alternatives.Transcatheter edge-to-edge repair (TEER) procedures have increasingly been used to improve the severity of both MR and TR, offering patients symptomatic relief and reductions in heart failure hospitalisation at low procedural risk. There is considerable geographic variation in protocols to assess these patients prior to the procedure and also in length of hospital stay. The standard of care in the UK, and particularly in Oxford, emphasises fewer investigations before the TEER procedure and shorter length of hospital stay.This prospective, observational cohort study will examine the safety and feasibility of this practice., conditionsModule conditions: Mitral Regurgitation, conditions: Tricuspid Regurgitation, conditions: Mitral Repair, conditions: Heart Failure, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Early discharge protocol, outcomesModule primaryOutcomes measure: Proportion of patients discharged 'early' after edge -to-edge repair, primaryOutcomes measure: All - cause rehospitalisation after completion of procedure, primaryOutcomes measure: All cause death after completion of procedure, secondaryOutcomes measure: Hospital length of stay, secondaryOutcomes measure: Proportion of patients requiring intensive care unit care, secondaryOutcomes measure: Safety outcomes a. Major adverse events at the time of the procedure b. Major adverse events (procedure/device related) up to 30 days, secondaryOutcomes measure: Symptomatic improvement, secondaryOutcomes measure: Heart failure hospitalisation, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: John Radcliffe Hospital, status: RECRUITING, city: Oxford, state: Oxfordshire, zip: OX3 9DU, country: United Kingdom, contacts name: Sam Dawkins, MBBS MRCP BSc DPhil, role: CONTACT, email: Sam.Dawkins@ouh.nhs.uk, geoPoint lat: 51.75222, lon: -1.25596, hasResults: False
protocolSection identificationModule nctId: NCT06343350, orgStudyIdInfo id: OPTDR01P, briefTitle: OPTDR01 Feasibility for Automated Diabetic Retinopathy Detection, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2024-10-30, completionDateStruct date: 2024-12-30, studyFirstPostDateStruct date: 2024-04-02, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Optain Health, class: INDUSTRY, descriptionModule briefSummary: In the United States, only 62% of the 37 million people with diabetes receive annual screening exams for diabetic retinopathy. One of the goals of the US Department of Health and Human Services Healthy People 2030 campaign is to increase diabetic retinopathy screening rates to 70.3%. Research indicates that low screening rates are associated with a variety of factors, including income levels, race and lack of access to care. Furthermore, because diabetic retinopathy frequently presents asymptomatically, non-adherence to screening results in postponed disease detection and a higher probability of vision loss. Currently, it is estimated that 9 million adults in the US are affected by diabetic retinopathy, and 1.8 million suffer from vision-threatening diabetic retinopathy. Importantly, the rates of vtDR vary greatly by race, with Hispanic individuals at 7.14% and Black individuals at 8.66%, compared to 3.55% in White individuals. Despite these alarming figures, the disease can be managed and vision loss can often be averted with early disease detection, thus highlighting the importance of increasing screening rates.A clear need exists for a diabetic retinopathy screening tool that can be deployed in primary care settings, addressing the shortage of specialist care and making screening more accessible to underserved populations. OPTDR01 will directly address these issues by providing accessible, high quality screening for diabetic retinopathy. OPTDR01 will automatically detect more than mild diabetic retinopathy (mtmDR) and vision-threatening diabetic retinopathy (vtDR) in diabetic adults who have not previously been diagnosed with mtmDR or vtDR., conditionsModule conditions: Diabetic Retinopathy, conditions: Diabetes, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 75, type: ESTIMATED, armsInterventionsModule interventions name: OPTDR01 software application, outcomesModule primaryOutcomes measure: Enrollment rate of eligible participants at clinical site, eligibilityModule sex: ALL, minimumAge: 22 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Precision Research Institute, city: San Diego, state: California, zip: 92114, country: United States, contacts name: Marie Inocentes, role: CONTACT, phone: 619-501-0371, phoneExt: 310, email: marie@prisandiego.com, geoPoint lat: 32.71533, lon: -117.15726, hasResults: False
protocolSection identificationModule nctId: NCT06343337, orgStudyIdInfo id: MSKUDİSCLİNİCALTRİALS_FYİLMAZ., briefTitle: The Effects of Pregnancy on Oral Health, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-05-20, primaryCompletionDateStruct date: 2023-04-01, completionDateStruct date: 2023-04-01, studyFirstPostDateStruct date: 2024-04-02, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Muğla Sıtkı Koçman University, class: OTHER, descriptionModule briefSummary: The aim of this study was to evaluate the effects of pregnancy on salivary pH, flow rate, caries experience and periodontal status.The main questions it aims to answer are:* Does pregnancy affect caries experience and periodontal status?* Does pregnancy affect salivary pH and flow rate?* Is there a difference between pregnant and non-pregnant woman with respect to caries experience, periodontal status, salivary pH and flow rate?* Is there a difference among first, second and third trimester with respect to caries experience, periodontal status, salivary pH and flow rate?, conditionsModule conditions: Pregnancy Related, conditions: Dental Caries, conditions: Periodontal Diseases, conditions: Saliva Altered, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: FACTORIAL, primaryPurpose: DIAGNOSTIC, maskingInfo masking: SINGLE, maskingDescription: The individual who evaluates the salivary pH and flow rate., whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 198, type: ACTUAL, armsInterventionsModule interventions name: Evaluation of DMFT index, CPI scores, salivary pH and flow rate in pregnant and non-pregnant woman, outcomesModule primaryOutcomes measure: The effects of pregnancy on caries experience, primaryOutcomes measure: The effects of pregnancy on periodontal status., primaryOutcomes measure: The effects of pregnancy on salivary pH., primaryOutcomes measure: The effects of pregnancy on salivary flow rate., eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 35 Years, stdAges: ADULT, contactsLocationsModule locations facility: Fatma Yilmaz, city: Mentese, state: Mugla, zip: 48000, country: Turkey, hasResults: False