hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06379126, orgStudyIdInfo id: Yuting Li05, briefTitle: The Diagnostic and Prognostic Value of TAT, PIC, tPAI·C and TM in Sepsis-induced Coagulopathy, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-20, primaryCompletionDateStruct date: 2026-04-20, completionDateStruct date: 2026-04-20, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: The First Hospital of Jilin University, class: OTHER, descriptionModule briefSummary: In order to evaluate the diagnostic and prognostic value of thrombin-antithrombin complex（TAT）, α2-plasmin inhibitor-plasmin complex（PIC）, tissue plasminogen activator-inhibitor complex（tPAI·C） and thrombomodulin（TM） in sepsis-induced coagulopathy(SIC), hospitalized patients with sepsis were prospectively included. Plasma TAT, PIC, tPAI·C,TM levels within 24 h after sepsis diagnosis were detected by MCL60 chemiluminescence analyzer. According to the SIC score (≥4), they were divided into SIC group and non-SIC group, and ROC curve analysis was performed according to the biomarker test results., conditionsModule conditions: Sepsis-induced Coagulopathy, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 210, type: ESTIMATED, armsInterventionsModule interventions name: Test thrombin-antithrombin complex（TAT）, α2-plasmin inhibitor-plasmin complex（PIC）, tissue plasminogen activator-inhibitor complex（tPAI·C） and thrombomodulin（TM）, outcomesModule primaryOutcomes measure: Thrombin-antithrombin complex（TAT）, α2-plasmin inhibitor-plasmin complex（PIC）, tissue plasminogen activator-inhibitor complex（tPAI·C） and thrombomodulin（TM） level, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06379113, orgStudyIdInfo id: 53211030-2, briefTitle: GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Cancer Patients, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-07-13, primaryCompletionDateStruct date: 2025-03-30, completionDateStruct date: 2025-03-30, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Xiaojun Chen, class: OTHER, descriptionModule briefSummary: To investigate the efficacy of GnRHa plus letrozole in obese progestin-insensitive EEC patients., conditionsModule conditions: Endometrial Neoplasms, conditions: Atypical Endometrial Hyperplasia, conditions: Progesterone Resistance, conditions: Obesity, designModule studyType: INTERVENTIONAL, phases: PHASE2, phases: PHASE3, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 29, type: ESTIMATED, armsInterventionsModule interventions name: GnRH antagonist, interventions name: Letrozole 2.5mg, outcomesModule primaryOutcomes measure: Complete response rates within 28 weeks of treatment, secondaryOutcomes measure: Adverse events, secondaryOutcomes measure: Time to achieve complete response, secondaryOutcomes measure: Relapse rates, secondaryOutcomes measure: Rates of fertility outcomes, secondaryOutcomes measure: Compliance, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: Obstetrics and Gynecology Hospital, Fudan University, status: RECRUITING, city: Shanghai, country: China, contacts name: Xiaojun Chen, role: CONTACT, phone: 862133189900, email: cxjlhjj@163.com, geoPoint lat: 31.22222, lon: 121.45806, hasResults: False
protocolSection identificationModule nctId: NCT06379100, orgStudyIdInfo id: KY20232388, briefTitle: Cerebellar iTBS Mode Transcranial Magnetic Stimulation for the Treatment of Alzheimer's Disease, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-25, primaryCompletionDateStruct date: 2024-08-25, completionDateStruct date: 2024-09-25, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Xijing Hospital, class: OTHER, descriptionModule briefSummary: Study the therapeutic effect and potential neural mechanisms of cerebellar iTBS mode transcranial magnetic stimulation on Alzheimer's disease patients through MRI and EEG., conditionsModule conditions: Transcranial Magnetic Stimulation, conditions: Alzheimer Disease, conditions: Magnetic Resonance Imaging, conditions: Electroencephalogram, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, maskingDescription: Alzheimer's disease patients were enrolled by expert neurol ogists who were blinded to treatment allocation. rTMS sessions were performed by dedicated technicians. The Cognitive evaluations and analysis of neuro physiological data were performed by expert neurophysiologists blinded to treatment allocation., whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 28, type: ESTIMATED, armsInterventionsModule interventions name: transcranial magnetic stimulation, outcomesModule primaryOutcomes measure: The changes in CDR（Clinical Dementia Rating）, secondaryOutcomes measure: The changes in MMSE(Mini Mental State Examination), secondaryOutcomes measure: NPI (Neuropsychiatric Inventory), secondaryOutcomes measure: ADL( Lawton-Brody Activities of Daily Living), secondaryOutcomes measure: DST (Digital Span Test; Forward and Backward), secondaryOutcomes measure: ADAS-cog（Alzheimer's disease assessment scale), secondaryOutcomes measure: DMS(Delayed matching-to-sample task), secondaryOutcomes measure: MEP（Motor evoked potential）, secondaryOutcomes measure: MRI measures, secondaryOutcomes measure: EEG（electroencephalogram）, eligibilityModule sex: ALL, minimumAge: 45 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Xijing Hospital of Air Force Military Medical University, city: Xi'an, state: Shaanxi, zip: 710032, country: China, contacts name: Wen Jiang, role: CONTACT, phone: 13991905538, email: jiangwen@fmmu.edu.cn, contacts name: Xin Zhang, role: CONTACT, phone: 13154378732, email: zx312316@163.com, geoPoint lat: 34.25833, lon: 108.92861, hasResults: False
protocolSection identificationModule nctId: NCT06379087, orgStudyIdInfo id: NEO-PIONEER, briefTitle: Radiation Therapy Followed by Tislelizumab and Anlotinib Aeoadjuvant/Adjuvant Therapy for Stage II-IIIA NSCLC, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: Ji Yongling, class: OTHER, descriptionModule briefSummary: This study is a single-center, prospective, single-arm exploratory clinical study of hypofractionated radiotherapy followed by tislelizumab and anlotinib neoadjuvant and adjuvant therapy. It is designed for patients with stage II-IIIA non-small cell lung cancer. The efficacy and safety of hypofractionated radiotherapy sequential tislelizumab and anlotinib in the neoadjuvant and adjuvant treatment of stage II-IIIA non-small cell lung cancer are observed. Finally, it provides new evidence-based medical evidence for the perioperative treatment of non-small cell lung cancer., conditionsModule conditions: Non-Small Cell Lung Cancer, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Anlotinib Hydrochloride Capsule, interventions name: Tislelizumab Injection, interventions name: Hypofractionated Radiotherapy, outcomesModule primaryOutcomes measure: 1-year EFS Rate, secondaryOutcomes measure: pCR Rate, secondaryOutcomes measure: MPR Rate, secondaryOutcomes measure: Adverse Events (AEs) according to CTCAE (V5.0) (Safety Evaluation), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06379061, orgStudyIdInfo id: MM-01-24, briefTitle: Access MeMed BV Assay Clinical Study Collection Protocol - Infectious Adult and Pediatric Cohorts, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2025-03-31, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Beckman Coulter, Inc., class: INDUSTRY, collaborators name: MeMed Diagnostics Ltd., descriptionModule briefSummary: The purpose of the pivotal study is to collect blood specimens and clinical data from pediatric (\>90 days old) and adult (≥18 years old) patients presenting with signs and symptoms suggestive of acute bacterial or viral infection. These samples will be used to establish the diagnostic performance of MeMed BV™ for differentiating bacterial from viral infection using method comparison and/or method concordance., conditionsModule conditions: Infection, Bacterial, conditions: Infection Viral, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: PROSPECTIVE, enrollmentInfo count: 400, type: ESTIMATED, outcomesModule primaryOutcomes measure: Blood Specimen Collection, eligibilityModule sex: ALL, minimumAge: 90 Days, maximumAge: 89 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06379048, orgStudyIdInfo id: 2021.12.282, briefTitle: The Impact of Different Skin Suture Methods in Episiotomy Repair on Healing and Pain, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-03-01, primaryCompletionDateStruct date: 2022-08-31, completionDateStruct date: 2022-09-20, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Başakşehir Çam & Sakura City Hospital, class: OTHER_GOV, descriptionModule briefSummary: Episiotomy is the intentional incision of the perineum during vaginal birth in order to accelerate the active phase of labor. This study aimed to compare various skin closure techniques in episiotomy repair., conditionsModule conditions: Labor; Prolonged, Second Stage, conditions: Episiotomy Wound, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 132, type: ACTUAL, armsInterventionsModule interventions name: Matress Suturing, interventions name: Primary Suturing, interventions name: Continuous Subcutaneous Suturing, outcomesModule primaryOutcomes measure: Healing by Redness, Edema, Ecchymosis and Discharge (REEDA) Score, primaryOutcomes measure: Pain by Visual Analog Scale (VAS), eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: Cam and Sakura City Hospital, city: Istanbul, state: Basaksehir, zip: 34494, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06379035, orgStudyIdInfo id: Protozoa in CRC patients, briefTitle: Blastocystis and Cryptosporidium Infection in Colorectal Cancer Patients, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-11-01, primaryCompletionDateStruct date: 2025-11-01, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: 1. Detect the prevelance of Blastocystis spp. and Cryptosporidium spp. among patients with colorectal cancer attending South Egypt Cancer Institute-Assiut University.2. Detect the effect of Blastocystis and Cryptosporidium infection on various cytokines level in CRC patients that may be involved in the tumor progression., conditionsModule conditions: Blastocystis Infection, conditions: Cryptosporidium Infection, conditions: Colorectal Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 54, type: ESTIMATED, armsInterventionsModule interventions name: ELISA / PCR, outcomesModule primaryOutcomes measure: Detect the prevelance of Blastocystis spp. and Cryptosporidium spp. among patients with colorectal cancer attending South Egypt Cancer Institute-Assiut University., secondaryOutcomes measure: Detect the effect of Blastocystis and Cryptosporidium infection on various cytokines level in CRC patients that may be involved in the tumor progression., eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06379022, orgStudyIdInfo id: AUTh-29/21-11-2018, briefTitle: Proteomic Analysis of Newly Restored Single Implants, statusModule overallStatus: COMPLETED, startDateStruct date: 2018-12-03, primaryCompletionDateStruct date: 2019-11-29, completionDateStruct date: 2019-11-29, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Aristotle University Of Thessaloniki, class: OTHER, collaborators name: Karolinska Institutet, descriptionModule briefSummary: In 10 systemically healthy non-smokers, free of periodontitis, one newly restored implant (baseline-T0) and one corresponding tooth were followed over 12 months (T1). All implants were screw-retained, and platform-switched. Oral hygiene was closely monitored during the study. Probing pocket depth (PPD), attachment levels (CAL), bleeding and plaque indices and crevicular fluid were collected from an implant-site (PICF) and a tooth-site (GCF). Total proteomic profiles in PICF and GCF were investigated using label-free quantitative proteomics., conditionsModule conditions: Peri-Implantitis, conditions: Peri-implant Mucositis, conditions: Periodontal Diseases, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 10, type: ACTUAL, armsInterventionsModule interventions name: Plaque control, outcomesModule primaryOutcomes measure: Probing pocket depth, primaryOutcomes measure: Protein expression, secondaryOutcomes measure: Recession, secondaryOutcomes measure: Bleeding upon probing, secondaryOutcomes measure: Inflammation index, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Dental School, Aristotle University, city: Thessaloniki, zip: 54124, country: Greece, geoPoint lat: 40.64361, lon: 22.93086, hasResults: False
protocolSection identificationModule nctId: NCT06379009, orgStudyIdInfo id: 473076, briefTitle: Effect of Home-based Training Program for Kidney Transplant Recipients (HOMETRAIN-KTR), statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-07, primaryCompletionDateStruct date: 2027-01-01, completionDateStruct date: 2028-01-01, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-24, sponsorCollaboratorsModule leadSponsor name: Oslo University Hospital, class: OTHER, collaborators name: South-Eastern Norway Regional Health Authority, descriptionModule briefSummary: Does home-based training work in kidney transplant recipients with reduced physical function?The goal of this clinical trial is to learn if home-based training works to better physical function in adult kidney transplant recipients. It will also learn about participants preoperative physical function. The main question it aim to answer is* Does home-based training improves physical function in kidney transplant recipients.* All the participants are assessed to have reduced physical function before the transplantationParticipants will:* follow either a home-based training program or todays standard of physical activity after kidney transplantation* the program starts 4 weeks after the transplantation and lasts for 12 weeks. A physiotherapist will help the participants in the beginning.* the program consists of both cardio-training, strength-straining and optional activity* the training group will be followed up every week by phone. Their activity will be documented via patients logs and heart rate monitor.* the effect of the training will be evaluated one year after the transplantation, conditionsModule conditions: Kidney Transplant; Complications, conditions: Frailty, conditions: Physical Disability, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: 2 arms randomized control study. The intervention arm is exposed of a 12 week home-based training program. The control arm follow standard of care., primaryPurpose: TREATMENT, maskingInfo masking: NONE, maskingDescription: Both participants and investigators will know which arm the participants are randomized to. Training is not easy to mask, enrollmentInfo count: 200, type: ESTIMATED, armsInterventionsModule interventions name: Training, outcomesModule primaryOutcomes measure: 6-minute walking distance test, primaryOutcomes measure: Clinical Frailty Scale, secondaryOutcomes measure: Hand-grip strength, secondaryOutcomes measure: 30 seconds Sit-to-stand test, secondaryOutcomes measure: Bone density test, secondaryOutcomes measure: Bioelectrical impedance phase angle to measure muscle mass and strength., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Oslo University Hospital, status: RECRUITING, city: Oslo, zip: 0372, country: Norway, geoPoint lat: 59.91273, lon: 10.74609, hasResults: False
protocolSection identificationModule nctId: NCT06378983, orgStudyIdInfo id: SYSKY-2023-1149-02, briefTitle: Clinical Trial of Microneedle Radiofrequency Combined With Oral Isotretinoin in Moderate to Severe Acne, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-09-01, primaryCompletionDateStruct date: 2024-06-30, completionDateStruct date: 2024-06-30, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, class: OTHER, descriptionModule briefSummary: This study plans to select 100 AV patients and randomly divide them into two groups in a 1:1 ratio: the experimental group will be treated with MRF combined with oral isotretinoic acid for 8 consecutive weeks, with a total of 3 MRF treatments at weeks 1, 4, and 8. The control group received oral administration of isotretinoic acid alone for 8 weeks. The main observation indicators are the percentage of effective skin injury clearance achieved by subjects at week 20, as well as the change in ECCA acne scar score compared to baseline at week 20. I hope this study can clarify that the combination therapy of the two can achieve the effects of improving efficacy, shortening treatment course, reducing recurrence, not increasing adverse reactions, and reducing the risk of scar formation., conditionsModule conditions: Moderate to Severe Acne Vulgaris, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Oral isotretinoin, interventions name: Oral isotretinoin combined with microneedle radiofrequency therapy, outcomesModule primaryOutcomes measure: Changes in ECCA acne scar score from baseline at week 20, primaryOutcomes measure: The percentage of effective skin lesion clearance rate in the 20th week, eligibilityModule sex: ALL, minimumAge: 14 Years, maximumAge: 65 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Department of Dermatology and Venereology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University., status: RECRUITING, city: Guangzhou, zip: 510030, country: China, contacts name: Sha Lu, role: CONTACT, phone: 13632383399, email: lush7@mail.sysu.edu.cn, geoPoint lat: 23.11667, lon: 113.25, hasResults: False
protocolSection identificationModule nctId: NCT06378970, orgStudyIdInfo id: 22-1T/49, briefTitle: Audio Books Effects on Anxiety and Vital Sings, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-04-15, primaryCompletionDateStruct date: 2022-07-15, completionDateStruct date: 2022-07-15, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Ege University, class: OTHER, descriptionModule briefSummary: Objectives: This study aimed to investigate the effect of audio book use on anxiety and vital signs in patients receiving non-invasive mechanical ventilation (NIMV) support.Research Methodology/Design: It is an experimental-randomised controlled study. Settings: The study was carried out with patients hospitalised in the Chest Diseases Intensive Care Unit of a university hospital and NIMV support. The participants consisted of 60 people, 30 in the intervention group and 30 in the control group. Before starting the application in the intervention group, the book preferences of the patients were determined and the selected audio book was played to the patients with headphones via tablet/smartphone. No additional application was made to the control group.Main Outcome Measures: Anxiety levels and vital signs in the intervention group were evaluated before, 15 minutes, 30 minutes and 30 minutes after the end of the intervention. In the control group, only routine care continued and anxiety levels, and vital signs were assessed simultaneously with the intervention group., conditionsModule conditions: Non-invasive Mechanical Ventilation, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomised Controlled, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 60, type: ACTUAL, armsInterventionsModule interventions name: Audio Book Application, outcomesModule primaryOutcomes measure: Facial Anxiety Scale, primaryOutcomes measure: Patient Follow-up Form, primaryOutcomes measure: Audio Book Application Preference Form, primaryOutcomes measure: Patient Information Form, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Ege University, city: Bornova, state: İzmir, zip: 35100, country: Turkey, geoPoint lat: 38.47921, lon: 27.2399, hasResults: False