protocolSection identificationModule nctId: NCT06362434, orgStudyIdInfo id: UHN-HHREHAB-24-xxxx, briefTitle: Visual Telerehabilitation in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour, acronym: HHREHAB, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-01, primaryCompletionDateStruct date: 2027-06-01, completionDateStruct date: 2027-06-01, studyFirstPostDateStruct date: 2024-04-12, lastUpdatePostDateStruct date: 2024-04-12, sponsorCollaboratorsModule leadSponsor name: University Health Network, Toronto, class: OTHER, collaborators name: Alberta Children's Hospital, collaborators name: St. Justine's Hospital, collaborators name: The Hospital for Sick Children, collaborators name: British Columbia Children's Hospital, descriptionModule briefSummary: Brain malignancies are the most common cause of death from cancer in the pediatric population and a major source of morbidity amongst survivors. Many children with a brain tumour often suffer from visual field defects (hemianopia) dramatically impacting their daily life with poorer social interaction, difficulties learning, playing sports and engaging with peers. Practically, they bump into people and objects and have problems in finding their way in unfamiliar places and in detecting incoming objects in their blind field. There is growing recognition of the diverse and deep impact of hemianopia on physical and mental health, quality of life, and social outcomes of the affected individuals and their family. However, despite the frequent impact of brain tumours on the visual function and functional vision, ophthalmologic evaluations are not standard of care for all brain tumour patients and there are no standardized protocols of vision loss management in the pediatric population with hemianopia. There is an unmet need of restoring perception in the blind field in individuals with hemianopia consecutive to pediatric brain tumor.Our laboratory has developed a visual rehabilitation procedure based on the combination of adaptative audio and visual target tracking in a 3D environment in virtual reality. Participants perform audiovisual stimulation at home in a headset, with remote control from the laboratory. Preliminary on data on paediatric patients with hemianopia consecutive to a brain tumour indicate feasibility and potential effectiveness of a 6-week Re:Vision program on visual fields, visual perception and quality of life.Our objective is to evaluate the effectiveness of Re:Vision, an 8-week visual telerehabilitation program, on visual perception in 50 individuals aged 10-40 years old with hemianopia consecutive to a pediatric brain tumor in a phase IIa/b multi-centric clinical study across Canada.This intervention provides more equitable access to individuals, with the ability to receive rehabilitation therapy at home without supervision by a healthcare professional, meaning that Canadians living outside urban centres could take advantage of specialized therapies with remote supervision. This is the first study that could lead to a major change in the management of these patients. It could open the door for visual rehabilitation strategies to other population of visually impaired children, significantly impacting public health strategies., conditionsModule conditions: Hemianopsia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Audiovisual stimulation, outcomesModule primaryOutcomes measure: Binocular Visual Field, secondaryOutcomes measure: Patient-related Outcome Measures - National Eye Institute - Visual Function Questionnaire - 25, secondaryOutcomes measure: Patient-related Outcome Measures - World Health Organization - Quality of Life questionnaire - BREF, secondaryOutcomes measure: Reading Speed, secondaryOutcomes measure: Fixation Stability, secondaryOutcomes measure: Contrast Sensitivity, otherOutcomes measure: Brain Activity - Visually-evoked potentials, otherOutcomes measure: Retinal Integrity, otherOutcomes measure: Brain imaging - Tractography, otherOutcomes measure: Brain imaging - Retinotopy, otherOutcomes measure: Head tracking, otherOutcomes measure: Eye tracking, eligibilityModule sex: ALL, minimumAge: 10 Years, maximumAge: 40 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Alberta Children's Hospital, city: Calgary, state: Alberta, zip: T3B 6A8, country: Canada, contacts name: Lucie Lafay-Cousin, MD, role: CONTACT, phone: 403-955-7272, email: llafayco@ucalgary.ca, contacts name: Lucie Lafay-Cousin, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.05011, lon: -114.08529, locations facility: British Columbia Children's Hospital, city: Vancouver, state: British Columbia, zip: V6H 3N1, country: Canada, contacts name: Sylvia Cheng, MD, role: CONTACT, phone: 604-875-2406, email: sylvia.cheng@cw.bc.ca, contacts name: Sylvia Cheng, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 49.24966, lon: -123.11934, locations facility: The Hospital for Sick Children, city: Toronto, state: Ontario, zip: M5G 1E8, country: Canada, contacts name: Eric Bouffet, MD, role: CONTACT, phone: 416-813-7500, email: eric.bouffet@sickkids.ca, contacts name: Eric Bouffet, MD, role: PRINCIPAL_INVESTIGATOR, contacts name: Uri Tabori, MD, role: SUB_INVESTIGATOR, contacts name: Inci Yaman Bajin, MD, role: SUB_INVESTIGATOR, geoPoint lat: 43.70011, lon: -79.4163, locations facility: Centre Hospitalier Universitaire Sainte-Justine, city: Montreal, state: Quebec, zip: H3T 1C5, country: Canada, contacts name: Sebastien Perreault, MD, role: CONTACT, phone: 514-345-2372, email: s.perreault@umontreal.ca, contacts name: Sebastien Perreault, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.50884, lon: -73.58781, locations facility: CHU de Québec, city: Québec, state: Quebec, zip: G1J 1Z4, country: Canada, contacts name: Valerie Larouche, MD, role: CONTACT, phone: 418-654-2282, email: valerie.larouche@fmed.ulaval.ca, contacts name: Valerie Larouche, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 46.81228, lon: -71.21454, hasResults: False