protocolSection identificationModule nctId: NCT06287138, orgStudyIdInfo id: KY2023-182-03, briefTitle: The Effect of Ciprofol on Breathing Patterns, Respiratory Drive, and Inspiratory Effort in Mechanically Ventilated Patients, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-05-10, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2025-03-31, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Capital Medical University, class: OTHER, descriptionModule briefSummary: Sedatives and analgesics are usually given for analgesic, anxiolytic, or sedating purposes for patients with critical illness, while they inevitably inhibit respiratory and circulatory function. Sometimes, patients receive deep sedation to induce hypoventilation or suppress spontaneous respiratory effort. The sedation level in clinical practice is usually assessed with subjective sedation scoring systems, such as the Richmond Agitation Sedation Scale (RASS). However, studies have found that sedation depth based on RASS is not a reliable marker of respiratory drive during critical illness. In recent years, researchers have proposed to monitor the effects of sedatives and analgesics on respiratory indicators and to implement lung-protective sedation, such as P0.1, Pocc, Pmus, WOB, and PTP. However, different pharmacological characteristics, different depths of sedation, and different sedation regimens among different sedatives and analgesics make a great difference in their effects on respiration. Ciprofol is an analog of propofol, with increased stereoselective effects adding to its anesthetic properties, is increasingly used in the intensive care unit, but its effects on respiration are not well understood. Therefore, this study aims to investigate the effects of ciprofol on respiratory patterns, respiratory drive, and inspiratory effort in mechanically ventilated patients., conditionsModule conditions: Mechanical Ventilation, conditions: Sedation and Analgesia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: ciprofol, outcomesModule primaryOutcomes measure: Explore the effect of ciprofol on tidal volume, primaryOutcomes measure: Explore the effect of ciprofol on respiratory rate, primaryOutcomes measure: Explore the effect of ciprofol on minute ventilation, primaryOutcomes measure: Explore the effect of ciprofol on P0.1, primaryOutcomes measure: Explore the effect of ciprofol on PMI, primaryOutcomes measure: Explore the effect of ciprofol on ΔPocc, secondaryOutcomes measure: Explore the effect of ciprofol on tidal volume, secondaryOutcomes measure: Explore the effect of ciprofol on respiratory rate, secondaryOutcomes measure: Explore the effect of ciprofol on minute ventilation, secondaryOutcomes measure: Explore the effect of ciprofol on P0.1, secondaryOutcomes measure: Explore the effect of ciprofol on PMI, secondaryOutcomes measure: Explore the effect of ciprofol on ΔPocc, secondaryOutcomes measure: Explore the effect of ciprofol on systolic blood pressure, secondaryOutcomes measure: Explore the effect of ciprofol on diastolic blood pressure, secondaryOutcomes measure: Explore the effect of ciprofol on mean arterial pressure, secondaryOutcomes measure: Explore the effect of ciprofol on heart rate, secondaryOutcomes measure: Explore the effect of ciprofol on saturation of pulse oxygen, secondaryOutcomes measure: Explore the effect of ciprofol on end-tidal carbon dioxide pressure, secondaryOutcomes measure: Explore the effect of ciprofol on RASS score, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Beijing Tiantan Hospital, status: RECRUITING, city: Beijing, state: Beijing, zip: 100071, country: China, contacts name: Jian-Xin Zhou, MD, role: CONTACT, phone: 8610 59978019, email: zhoujx.cn@icloud.com, contacts name: Rui Su, role: CONTACT, phone: +8618611993866, email: surui1969@163.com, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False