hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06379295, orgStudyIdInfo id: CHUO-2024-05, briefTitle: Coronary Artery Calcification Assessed on PET/CT, acronym: CALCOTEP, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-21, primaryCompletionDateStruct date: 2025-05-21, completionDateStruct date: 2025-05-21, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Centre Hospitalier Régional d'Orléans, class: OTHER, descriptionModule briefSummary: Calcification artery calcium (CAC) scoring is a valuable tool for determining the risk of major adverse cardiac events.It was found that CAC can be quantitatively assessed, by manual scoring or using deep-learning, on low-dose non ECG-gated, contrast-enhanced or non-enhanced CT scans performed in association of PET acquisition, with a good agreement with standard scans.The purpose of this study is to determine the impact of a systematic coronary artery calcification evaluation in patients undergoing 18F-FDG PET/CT imaging to improve primary prevention of cardiovascular diseases.A visual CAC assessment will be made for each patient, dividing them into four groups: none, mild, moderate or heavy CAC. When possible, a CAC score will be computed.Each patient will complete a questionnaire to collect risk factors, history of cardiovascular diseases and medications., conditionsModule conditions: Coronary Artery Disease, conditions: Coronary Artery Calcification, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 200, type: ESTIMATED, armsInterventionsModule interventions name: Questionnaire, outcomesModule primaryOutcomes measure: Prevalence of moderate CAC in participants without history of cardiac disease, secondaryOutcomes measure: Prevalence of coronary heart disease among participants, secondaryOutcomes measure: Correlation of CAC with the medical indication for PET imaging, secondaryOutcomes measure: Prevalence of CAC in young participants (< 45 years old), secondaryOutcomes measure: Prevalence of moderate CAC in participants not taking low-cholesterol drug, secondaryOutcomes measure: Prevalence of no CAC in participants taking statins, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06379282, orgStudyIdInfo id: FHMS 21-22 263 EGA, briefTitle: Investigating the Role of Energy Balance Modification on Health Responses in Chronic Lymphocytic Leukaemia, acronym: HIT-CLL, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-10-14, primaryCompletionDateStruct date: 2025-08-01, completionDateStruct date: 2026-08-01, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-24, sponsorCollaboratorsModule leadSponsor name: University of Surrey, class: OTHER, collaborators name: American Society of Hematology, descriptionModule briefSummary: This randomised control clinical trial aims to investigate the effects of exercise training and diet on physical and functional fitness and immunological and metabolic changes in adults with chronic lymphocytic leukaemia. Investigators will randomise participants to either 12 weeks of supervised/semi-supervised exercise only, exercise + nutritional guidance, or no exercise., conditionsModule conditions: Chronic Lymphocytic Leukemia, conditions: Frailty, conditions: Muscle Function, conditions: Immune Function, conditions: Lipid Cell; Tumor, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Recruited participants will be randomised to either exercise only, exercise + nutritional guidance, or control for 12 weeks, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 132, type: ESTIMATED, armsInterventionsModule interventions name: HIT, interventions name: EXE+ Nutritional Guidance, outcomesModule primaryOutcomes measure: Change from baseline in absolute number of CD19+/CD5+ CLL cells at week 12, primaryOutcomes measure: Change from baseline in cardiorespiratory fitness (CRF: VO2peak) at week 12, secondaryOutcomes measure: Frailty, secondaryOutcomes measure: Muscle Strength and Endurance, secondaryOutcomes measure: Muscle Health, secondaryOutcomes measure: Change in Quality of Life using the EORCT-QLQ-C30, secondaryOutcomes measure: Change in muscle oxygen metabolism during a single bout of exercise, secondaryOutcomes measure: Change in B-CLL Cell Function, secondaryOutcomes measure: Change in systemic and cellular bioenergetics, otherOutcomes measure: Legacy Effect of Intervention on change in cardiorespiratory fitness (VO2peak) as measured by a cardiopulmonary exercise test, otherOutcomes measure: Legacy Effect of Intervention on absolute number of CD19+/CD5+ CLL cells, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Surrey, status: RECRUITING, city: Guildford, zip: GU2 7WG, country: United Kingdom, contacts name: David Bartlett, PhD, role: CONTACT, phone: 01483 683 45, email: d.bartlett@surrey.ac.uk, geoPoint lat: 51.23536, lon: -0.57427, hasResults: False
protocolSection identificationModule nctId: NCT06379269, orgStudyIdInfo id: CMUH112-REC3-160, briefTitle: Effectiveness Verification of a Smartphone-based System for Assessment and Health Care on Myofascial Pain Syndrome, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2024-06, completionDateStruct date: 2024-12, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-24, sponsorCollaboratorsModule leadSponsor name: China Medical University Hospital, class: OTHER, collaborators name: National Cheng Kung University, collaborators name: National Science and Technology Council, descriptionModule briefSummary: Myofascial pain syndrome (MPS) is the most common musculoskeletal pain disorder. The pain originates from myofascial trigger points (TrPs) in skeletal muscle. The muscle that presents with TrPs would be identified through clinical diagnosis and assessment, and further treatment would be designed according to the identified muscle.With the high penetration rate of smartphones, it would be convenient to utilize smartphones as the assistive technology in the assessment and intervention of MPS. The smartphone-based MPS assessment and care system could eliminate the restrictions of the epidemic, and provide an independent usage, precisely identifying muscle with TrPs and personalized care plan application. Therefore, the purpose of this study is to 1. develop a smartphone-based assessment and health care system for patients with myofascial pain syndrome. And to 2. verify the feasibility and validity of the system assessment function. And to 3. testify the effectiveness of the system health care functions for patient intervention., conditionsModule conditions: Myofascial Pain Syndrome, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: INVESTIGATOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: App healthcare, interventions name: Control, outcomesModule primaryOutcomes measure: current pain visual analogue scale, secondaryOutcomes measure: functional questionnaire, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06379256, orgStudyIdInfo id: 202400364B0, briefTitle: Evaluation of Immune Responses and Outcomes in Patients With Hepatocellular Carcinoma Undergoing Radiotherapy, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-26, primaryCompletionDateStruct date: 2029-03-17, completionDateStruct date: 2032-03-17, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Chang Gung Memorial Hospital, class: OTHER, descriptionModule briefSummary: Radiation therapy (RT) is a highly effective modality for managing localized solid tumors and has become a fundamental component of treating unresectable hepatocellular carcinoma (HCC). Our previous preclinical investigation (Hsieh et al., Science Immunology 2022) revealed that RT can initiate immunogenic cell death and facilitate the cross-presentation of tumor antigens by antigen-presenting cells, thereby augmenting systemic anti-tumor T cell responses in murine tumor models. However, this immune response subsequent to irradiation has not been comprehensively evaluated in clinical trials involving HCC patients. Given that RT represents a standard therapeutic approach for unresectable HCC, our ongoing phase II non-randomized trial aims to prospectively assess immunological responses and dose-volumetric parameters, while identifying predictors of clinical outcomes in patients undergoing definitive RT for HCC., conditionsModule conditions: Hepatocellular Carcinoma, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 300, type: ESTIMATED, armsInterventionsModule interventions name: Photon or proton radiotherapy, outcomesModule primaryOutcomes measure: Progression free survival (PFS), secondaryOutcomes measure: Local control (LC), secondaryOutcomes measure: Time to progression (TTP), secondaryOutcomes measure: Overall Response Rate (ORR), secondaryOutcomes measure: Overall survival (OS), secondaryOutcomes measure: Incidence and severity of adverse events, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Chang Gung Memorial Hospital at Linkou, city: Taoyuan City, zip: 333, country: Taiwan, geoPoint lat: 24.95233, lon: 121.20193, hasResults: False
protocolSection identificationModule nctId: NCT06379243, orgStudyIdInfo id: KY-2023-008-02, briefTitle: Development and Validation of a Postoperative Re-fracture Risk Model for Osteoporotic Spinal Fractures, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-01, primaryCompletionDateStruct date: 2026-12-31, completionDateStruct date: 2027-12-31, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: The Seventh Affiliated Hospital of Sun Yat-sen University, class: OTHER, collaborators name: The Fourth Affiliated Hospital of Guangzhou Medical University, collaborators name: Huizhou Municipal Central Hospital, collaborators name: Dongguan Hospital of Traditional Chinese Medicine, descriptionModule briefSummary: In this project, IDEAL-IQ technology and PDFF and R2\* image-based imaging methods are used to analyze the intrinsic relationship between preoperative vertebral bone marrow fat content, magnetic susceptibility properties of bone tissue and bone strength (bone volume and bone mass), to explore the mechanism of vertebral re-fracture after PVP / PKP, and to explore the imaging markers for the risk of postoperative vertebral re-fracture after PVP / PKP. To construct a precise and individualized risk assessment model of vertebral re-fracture after PVP/ PKP by combining clinical risk factors, preoperative quantitative MRI parameters (PDFF, R2\*) and imaging characteristics, so as to achieve the goal of objectively and accurately evaluating the risk of vertebral re-fracture at the early stage of the postoperative period (1 year)., conditionsModule conditions: Osteoporosis Fracture, conditions: Osteoporosis Vertebral, conditions: Compression Fracture, conditions: Perform PVP / PKP Treatment, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 560, type: ESTIMATED, armsInterventionsModule interventions name: PVP/PKP, outcomesModule primaryOutcomes measure: Non-operative vertebral re-fracture within 1 year after PVP / PKP, secondaryOutcomes measure: Visual Analog Score (VAS) at 1 year after PVP/ PKP, secondaryOutcomes measure: Oswestry Dysfunction Index (ODI) at 1 year after PVP/PKP, eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The Seventh Affiliated Hospital, Sun Yat-sen University, status: RECRUITING, city: Guangzhou, state: Guangdong, country: China, contacts name: Kuiqing Lu, role: CONTACT, phone: 0755-81207263, email: lukq@mail.sysu.edu.cn, geoPoint lat: 23.11667, lon: 113.25, hasResults: False
protocolSection identificationModule nctId: NCT06379204, orgStudyIdInfo id: No.2022026, briefTitle: A Study on the Intervention of Metabolic Syndrome Patients With Exercise Prescription Based on Ventilatory Threshold Using Cardiopulmonary Exercise Test, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-11-04, primaryCompletionDateStruct date: 2023-08-30, completionDateStruct date: 2023-09-19, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Taiyuan Central Hospital of Shanxi Medical University, class: OTHER, descriptionModule briefSummary: Analyze the clinical intervention effects and differences of progressive precision exercise prescriptions formulated by two methods for determining exercise intensity on metabolic syndrome (MS). Compare the effects of the two on the cardiovascular endurance of the MS population and verify the effectiveness of individualized methods in reducing absolute exercise intensity for MS patients., conditionsModule conditions: Metabolic Syndrome X, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 52, type: ACTUAL, armsInterventionsModule interventions name: the maximum physiological value standardized group, interventions name: the ventilatory threshold individualized group, outcomesModule primaryOutcomes measure: Peak oxygen uptake, eligibilityModule sex: ALL, minimumAge: 25 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Taiyuan Cardiac Rehabilitation Center, city: Taiyuan, state: Shanxi, zip: 030009, country: China, geoPoint lat: 37.86944, lon: 112.56028, hasResults: False
protocolSection identificationModule nctId: NCT06379191, orgStudyIdInfo id: ZS-3411, briefTitle: The Efficacy of WeChat-based Multidisciplinary Full-course Nutritional Management Program, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-02-01, primaryCompletionDateStruct date: 2023-10-30, completionDateStruct date: 2023-10-30, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Peking Union Medical College Hospital, class: OTHER, descriptionModule briefSummary: As the most malignant type of cancer in the female reproductive system, ovarian cancer (OC) has become the second leading cause of death among Chinese women. Chemotherapy is the main treatment for OC patients, and its numerous adverse effects can easily lead to malnutrition. It is difficult to centrally manage OC patients in the intervals between chemotherapy. The utility of WeChat, an effective and more cost-efficient mobile tool, in chronic disease management has been highlighted., conditionsModule conditions: Ovarian Cancer, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: NONE, enrollmentInfo count: 78, type: ACTUAL, armsInterventionsModule interventions name: Nutrition intervention model based on WeChat applets, outcomesModule primaryOutcomes measure: patient-generated subjective global assessment (PG-SGA), secondaryOutcomes measure: nutrition-related blood indices, such as total protein (g/L), albumin (g/L), prealbumin (g/L), and hemoglobin (g/L), secondaryOutcomes measure: inflammation-related blood indices, such as leukocytes (10^9/L), lymphocytes (10^9/L), neutrophils (10^9/L), and platelets (10^9/L), secondaryOutcomes measure: nutrition-inflammation composite indices, such as prognostic nutritional index (PNI) and systemic immunoinflammatory index (SII), eligibilityModule sex: FEMALE, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, city: Beijing, state: Beijing, country: China, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False
protocolSection identificationModule nctId: NCT06379178, orgStudyIdInfo id: 6462e56fe8177, briefTitle: Effect of Oral Colostrum Applications Every 2 Hours and 4 Hours In Order to Achieve Trophic Feeding in Preterm Infants, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-02-19, primaryCompletionDateStruct date: 2023-08-15, completionDateStruct date: 2023-08-31, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Gadjah Mada University, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is aims to evaluate the effects of applying colostrum orally every 4 and 2 hours in order to achieve trophic feeding in preterm infants. The main question it aims to answer is the optimal frequency of colostrum application that can be applied Participants will be divided by randomization using permutation blocks after meeting the inclusion and exclusion criteria and deemed eligible. These blocks were then randomized using computer software such as Microsoft Excel, determining the sequence for allocation to the control and intervention groups based on the randomization order from the permutation code, every 2 hours and every 4 hours. Researchers will investigate the effects of oropharyngeal colostrum application frequency, every 4 hours and every 2 hours, in order to achieve trophic feeding in preterm infants \<34 weeks gestational age., conditionsModule conditions: Trophic Feeding, conditions: Very Low Birth Weight Baby, conditions: Preterm, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 47, type: ACTUAL, armsInterventionsModule interventions name: Oral colostrum application 2 hours, interventions name: Oral colostrum application 4 hours, outcomesModule primaryOutcomes measure: Days to Achieve Trophic Feeding, eligibilityModule sex: ALL, maximumAge: 2 Days, stdAges: CHILD, contactsLocationsModule locations facility: Neonatal Intensive Care Unit RSUP Dr. Sardjito, city: Sleman, state: Daerah Istimewa Yogyakarta, zip: 55281, country: Indonesia, geoPoint lat: -7.71556, lon: 110.35556, hasResults: False
protocolSection identificationModule nctId: NCT06379165, orgStudyIdInfo id: SYH9015-002, briefTitle: Efficacy and Safety Study of Meloxicam Nanocrystal Injection for the Treatment of Moderate to Severe Pain, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-05-17, primaryCompletionDateStruct date: 2023-07-11, completionDateStruct date: 2023-07-13, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: CSPC ZhongQi Pharmaceutical Technology Co., Ltd., class: INDUSTRY, descriptionModule briefSummary: The purpose of this study is to evaluate the efficacy and safety of meloxicam nanocrystal injection in subjects with moderate to severe pain after abdominal surgery., conditionsModule conditions: Pain, designModule studyType: INTERVENTIONAL, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 192, type: ACTUAL, armsInterventionsModule interventions name: Meloxicam Nanocrystal Injection, interventions name: Placebo, outcomesModule primaryOutcomes measure: PID24 (Time Weighted Sum of Pain Intensity Difference Over 24 Hours Post-Dose), secondaryOutcomes measure: TOTPAR (time-weighted sum of pain relief scores): TOTPAR12, TOTPAR18, TOTPAR24, TOTPAR48., secondaryOutcomes measure: SPID2、SPID6、SPID12、SPID18、SPID18-24、SPID24-48、SPID42-48、SPID48, secondaryOutcomes measure: Time to the first dose of the remedial analgesia, secondaryOutcomes measure: Number of times of remedial analgesia administered 0-24h and 24-48h after the first dose, secondaryOutcomes measure: Proportion of subjects requiring remedial analgesia, secondaryOutcomes measure: The total amount of remedial analgesia used 24 h and 48 h after the first dose, secondaryOutcomes measure: The subject's analgesic treatment satisfaction score (0-4 point categorical scale score), secondaryOutcomes measure: The investigator's satisfaction score (0-4 point categorical scale score) for the subject's analgesic treatment, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Union Hospital of Tongji Medical College of Huazhong University of Science and Technology, city: Wuhan, country: China, geoPoint lat: 30.58333, lon: 114.26667, hasResults: False
protocolSection identificationModule nctId: NCT06379152, orgStudyIdInfo id: 2024-04-16, briefTitle: Effect of Bilirubin on Prognosis in Heart Failure With Preserved Ejection Fraction, statusModule overallStatus: RECRUITING, startDateStruct date: 2020-09-20, primaryCompletionDateStruct date: 2024-06-30, completionDateStruct date: 2024-07-01, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Chongqing Medical University, class: OTHER, descriptionModule briefSummary: Factors influencing the prognosis of patients with heart failure with preserved ejection fraction (HFpEF) have been extensively studied. Previous studies have found that elevated serum total bilirubin levels are associated with cardiac death, heart failure readmission, and all-cause mortality in patients with chronic heart failure. However, the relationship between direct bilirubin and prognosis in patients with HFpEF is unclear., conditionsModule conditions: Heart Failure With Preserved Ejection Fraction, conditions: Prognathism, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 400, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: The level of direct bilirubin, primaryOutcomes measure: a composite of heart failure rehospitalization or all-cause mortality, secondaryOutcomes measure: heart failure rehospitalization, secondaryOutcomes measure: all-cause mortality, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The First Affiliated Hospital of Chongqing Medical University, status: RECRUITING, city: Chongqing, country: China, contacts name: Dongying Zhang, doctor, role: CONTACT, phone: +8613608398395, email: zdy.chris@qq.com, geoPoint lat: 29.56278, lon: 106.55278, hasResults: False