protocolSection identificationModule nctId: NCT06340646, orgStudyIdInfo id: 202106129, secondaryIdInfos id: U2CCA252981, type: NIH, link: https://reporter.nih.gov/quickSearch/U2CCA252981, briefTitle: Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS), statusModule overallStatus: RECRUITING, startDateStruct date: 2022-10-18, primaryCompletionDateStruct date: 2027-01-31, completionDateStruct date: 2027-01-31, studyFirstPostDateStruct date: 2024-04-01, lastUpdatePostDateStruct date: 2024-04-01, sponsorCollaboratorsModule leadSponsor name: Washington University School of Medicine, class: OTHER, collaborators name: National Cancer Institute (NCI), collaborators name: The Foundation for Barnes-Jewish Hospital, descriptionModule briefSummary: The overall goal of the WU-PE-CGS is to build a rigorous, scientific evidence base for approaches that direct engagement of cancer patients and post-treatment cancer survivors as participants in cancer research, and to investigate the impact of directly engaging participants in decisions regarding returning of genomic results on participants' health and satisfaction. Participants in this study will be presented with the choice of types of genomic results to receive, and the Engagement Optimization Unit (EOU) will investigate the impact of this intervention on participant knowledge, expectations of benefit, personal utility, and decisional conflict., conditionsModule conditions: Cholangiocarcinoma, conditions: Multiple Myeloma, conditions: Colon Cancer, conditions: Rectal Cancer, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: NONE, enrollmentInfo count: 990, type: ESTIMATED, armsInterventionsModule interventions name: Return of Genetic Results: Biomarker information from cancer cells, interventions name: Return of Genetic Results: Inherited mutations related to cancer, interventions name: Return of Genetic Results: Inherited mutations related to other medical issues, outcomesModule primaryOutcomes measure: Participant knowledge of clinical genetic testing, primaryOutcomes measure: Participant expectations of benefit, primaryOutcomes measure: Participant personal utility, secondaryOutcomes measure: Participant anxiety, secondaryOutcomes measure: Participant satisfaction, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Washington University School of Medicine, status: RECRUITING, city: Saint Louis, state: Missouri, zip: 63110, country: United States, contacts name: Graham Colditz, M.D., DrPH, MPH, role: CONTACT, phone: 314-454-7939, email: colditzg@wustl.edu, contacts name: Bettina Drake, Ph.D., MPH, role: CONTACT, phone: 314-747-4534, email: drakeb@wustl.edu, contacts name: Graham Colditz, M.D., DrPH, MPH, role: PRINCIPAL_INVESTIGATOR, contacts name: Li Ding, Ph.D., role: SUB_INVESTIGATOR, contacts name: Bettina Drake, Ph.D., role: SUB_INVESTIGATOR, contacts name: Ryan Fields, M.D., role: SUB_INVESTIGATOR, contacts name: Yin Cao, ScD, MPH, role: SUB_INVESTIGATOR, contacts name: Feng Chen, Ph.D., role: SUB_INVESTIGATOR, contacts name: Kia Davis, ScD, MPH, role: SUB_INVESTIGATOR, contacts name: Patricia Dickson, M.D., role: SUB_INVESTIGATOR, contacts name: Eric Duncavage, M.D., role: SUB_INVESTIGATOR, contacts name: Mark Fiala, MSW, role: SUB_INVESTIGATOR, contacts name: Aimee James, Ph.D., MPH, role: SUB_INVESTIGATOR, contacts name: Reyka Jayasinge, Ph.D., role: SUB_INVESTIGATOR, contacts name: Kian-Huat Lim, M.D., Ph.D., role: SUB_INVESTIGATOR, contacts name: Erin Linnenbringer, Ph.D., MS, role: SUB_INVESTIGATOR, contacts name: Jessica Mozersky, Ph.D., role: SUB_INVESTIGATOR, contacts name: Mary Politi, Ph.D., role: SUB_INVESTIGATOR, contacts name: David Spencer, M.D., Ph.D., role: SUB_INVESTIGATOR, contacts name: Tunji Toriola, M.D., Ph.D., MPH, role: SUB_INVESTIGATOR, contacts name: Ravi Vij, M.D., MBA, role: SUB_INVESTIGATOR, contacts name: Mark Watson, M.D., Ph.D., role: SUB_INVESTIGATOR, contacts name: Fei Wan, Ph.D., role: SUB_INVESTIGATOR, contacts name: Mike Wendl, DSC, MS, PHS, role: SUB_INVESTIGATOR, contacts name: Matthew Wyczalkowsi, Ph.D., role: SUB_INVESTIGATOR, contacts name: Stephanie Solomon Cargill, Ph.D., MSPH, role: SUB_INVESTIGATOR, geoPoint lat: 38.62727, lon: -90.19789, hasResults: False