protocolSection identificationModule nctId: NCT06305728, orgStudyIdInfo id: 23-367, briefTitle: A Study of Early Cancer Detection in People at High Risk of Developing Pancreatic Ductal Adenocarcinoma (PDAC), statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-04, primaryCompletionDateStruct date: 2030-03-04, completionDateStruct date: 2030-03-04, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: Memorial Sloan Kettering Cancer Center, class: OTHER, descriptionModule briefSummary: The purpose of this study is for researchers to find ways of detecting pancreatic ductal adenocarcinoma/PDAC early to avoid the invasive procedure of surgery. The study researchers think a combination of imaging and a series of blood tests may be an effective way to detect PDAC early. In this study, researchers will look at whether a combination of the following types of imaging with blood tests can detect PDAC in pancreatic cysts:* The ImmunoPET scan (immune-positron emission tomography scan) with the imaging agent 89Zr-DFO-HuMab-5B1* The HP MRI scan (hyperpolarized pyruvate magnetic resonance imaging scan), conditionsModule conditions: Pancreatic Cyst, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 25, type: ESTIMATED, armsInterventionsModule interventions name: 89Zr-DFO-HuMab-5B1 immunoPET, interventions name: HP MRI, interventions name: Blood assay, outcomesModule primaryOutcomes measure: Sensitivity of ImmunoPET to identify presence or absence of adenocarcinoma, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities), status: RECRUITING, city: Basking Ridge, state: New Jersey, zip: 07920, country: United States, contacts name: Kevin Soares, MD, role: CONTACT, phone: 212-639-3195, geoPoint lat: 40.70621, lon: -74.54932, locations facility: Memorial Sloan Kettering Monmouth (Limited protocol activities), status: RECRUITING, city: Middletown, state: New Jersey, zip: 07748, country: United States, contacts name: Kevin Soares, MD, role: CONTACT, phone: 212-639-3195, geoPoint lat: 40.39652, lon: -74.09211, locations facility: Memorial Sloan Kettering Bergen (Limited Protocol Activities), status: RECRUITING, city: Montvale, state: New Jersey, zip: 07645, country: United States, contacts name: Kevin Soares, MD, role: CONTACT, phone: 212-639-3195, geoPoint lat: 41.04676, lon: -74.02292, locations facility: Memorial Sloan Kettering Suffolk-Commack (Limited protocol activity), status: RECRUITING, city: Commack, state: New York, zip: 11725, country: United States, contacts name: Kevin Soares, MD, role: CONTACT, phone: 212-639-3195, geoPoint lat: 40.84288, lon: -73.29289, locations facility: Memorial Sloan Kettering Westchester (Limited Protocol Activities), status: RECRUITING, city: Harrison, state: New York, zip: 10604, country: United States, contacts name: Kevin Soares, MD, role: CONTACT, phone: 212-639-3195, geoPoint lat: 40.96899, lon: -73.71263, locations facility: Memorial Sloan Kettering Cancer Center (All protocol activites), status: RECRUITING, city: New York, state: New York, zip: 10065, country: United States, contacts name: Kevin Soares, MD, role: CONTACT, phone: 212-639-3195, geoPoint lat: 40.71427, lon: -74.00597, locations facility: Weill Cornell Medical Center (Specimen Analysis Only), status: NOT_YET_RECRUITING, city: New York, state: New York, zip: 10065, country: United States, contacts name: David Lyden, MD, role: CONTACT, phone: 212-746-6565, geoPoint lat: 40.71427, lon: -74.00597, locations facility: Memorial Sloan Kettering Nassau (Limited Protocol Activites), status: RECRUITING, city: Rockville Centre, state: New York, zip: 11553, country: United States, contacts name: Kevin Soares, PhD, role: CONTACT, phone: 212-639-3195, geoPoint lat: 40.65871, lon: -73.64124, hasResults: False