hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06298916, orgStudyIdInfo id: FAPi-1301, briefTitle: 64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer, acronym: PHANTOM, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2025-11, completionDateStruct date: 2026-04, studyFirstPostDateStruct date: 2024-03-07, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Lantheus Medical Imaging, class: INDUSTRY, descriptionModule briefSummary: This is a multicenter, open-label, prospective Phase 1/2a study to assess safety and tolerability, establish dosimetry and to identify an optimal imaging dose (radioactivity and mass dose) and imaging time window of 64Cu-LNTH-1363S (64Cu Radiolabeled FAPi PET/CT Imaging Agent) and to compare its imaging biodistribution with FAP expression by immunohistochemistry (IHC) in patients with sarcomas or GIT cancers. The study will be conducted in 2 parts (Part 1 and Part 2)., conditionsModule conditions: Metastatic Sarcoma, conditions: Esophageal Cancer, conditions: Gastric Cancer, conditions: Pancreatic Cancer, conditions: Colorectal Cancer, conditions: Sarcoma, designModule studyType: INTERVENTIONAL, phases: PHASE1, phases: PHASE2, designInfo allocation: NON_RANDOMIZED, interventionModel: SEQUENTIAL, interventionModelDescription: Part 1: Metastatic Sarcoma Part 2: Non-metastatic sarcoma or gastrointestinal tract (GIT) cancer (esophageal, gastric, pancreatic, colorectal cancer), primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 32, type: ESTIMATED, armsInterventionsModule interventions name: 64Cu-LNTH-1363S, outcomesModule primaryOutcomes measure: Primary Part 1 Biodistribution of 64Cu-LNTH-1363S, primaryOutcomes measure: Primary Part 1 - Optimal dose (radioactivity and mass dose) and imaging time window of 64Cu-LNTH-1363S, primaryOutcomes measure: Primary Part 2 - Correlation of 64Cu-LNTH-1363S biodistribution with Immunohistochemistry FAP expression, secondaryOutcomes measure: Secondary Parts 1 and 2 Safety and Tolerability, secondaryOutcomes measure: Secondary Part 1 FAP expression profile of 64Cu-LNTH-1363S in patients with sarcoma, secondaryOutcomes measure: Secondary Part 1 and Part 2 Cardiac Safety, secondaryOutcomes measure: Secondary Part 2 Validate optimal radioactivity in patients with sarcoma or GIT cancer, otherOutcomes measure: Exploratory Part 1 and Part 2, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06298903, orgStudyIdInfo id: STUDY00002565, briefTitle: Impact of Hip Activation Compared to Hip Plus Balance Training on the Forward-Step-Down Test, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2024-01-12, primaryCompletionDateStruct date: 2024-03-25, completionDateStruct date: 2024-08, studyFirstPostDateStruct date: 2024-03-07, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: Louisiana State University Health Sciences Center Shreveport, class: OTHER, descriptionModule briefSummary: The purpose of this research is to determine the impact of a hip activation home exercise program (HEP) compared to a hip activation + single leg balance HEP on performance of the Forward-Step-Down Test (FSDT) in healthy females. Participants will be assigned to the control (hip activation HEP only) or experimental (hip activation + single leg balance HEP). Following the pre-test data collection, participants will complete their HEP for 8 weeks. They will return to the lab for post-test measurements., conditionsModule conditions: Control of Frontal Plane Biomechanics, conditions: Patellofemoral Pain Syndrome, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: SINGLE, maskingDescription: The investigator who will analyze the data will be blinded, whoMasked: INVESTIGATOR, enrollmentInfo count: 34, type: ACTUAL, armsInterventionsModule interventions name: Hip Activation, interventions name: Hip activation + Single leg balance, outcomesModule primaryOutcomes measure: Forward-Step-Down Test, secondaryOutcomes measure: surface electromyography (sEMG) peak, secondaryOutcomes measure: surface electromyography (sEMG) mean, secondaryOutcomes measure: Unipedal Stance Test (UPST), secondaryOutcomes measure: Dose-Response, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: LSUHSC-Shreveport, city: Shreveport, state: Louisiana, zip: 71103, country: United States, geoPoint lat: 32.52515, lon: -93.75018, hasResults: False
protocolSection identificationModule nctId: NCT06298890, orgStudyIdInfo id: SASKAT, briefTitle: The Pattern of Dry Eye Disease After Cataract Surgery, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2026-05, completionDateStruct date: 2027-09, studyFirstPostDateStruct date: 2024-03-07, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Lithuanian University of Health Sciences, class: OTHER, collaborators name: Santen Oy, descriptionModule briefSummary: This study is designed to explore dry eye disease (DED) pattern: ocular surface, corneal morphological changes, patients' subjective assessment of DED and their correlations with ocular surface inflammation, pain biomarkers after cataract surgery according to ocular surface lubrication with artificial tears during long-term follow-up., conditionsModule conditions: Dry Eye Disease, conditions: Cataract, conditions: Ocular Surface Disease, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Artificial tears (sodium hyaluronate 0.2%), outcomesModule primaryOutcomes measure: Assessment of ocular surface changes following cataract surgery, primaryOutcomes measure: Evaluation of the cornea morphology, primaryOutcomes measure: Evaluation of matrix metalloproteinase-9 (MMP-9) levels in patients' tears, primaryOutcomes measure: Evaluation of tear osmolarity, primaryOutcomes measure: Evaluation of tear cytokine levels, primaryOutcomes measure: Assessment of central corneal sensitivity, secondaryOutcomes measure: Evaluation of potential pain biomarkers in patients' saliva, secondaryOutcomes measure: Dry Eye Questionnaire-5 (DEQ5) 5-item, secondaryOutcomes measure: Ocular surface disease index (OSDI), secondaryOutcomes measure: Visual function (VFQ-25) questionnaire, secondaryOutcomes measure: Visual acuity evaluation (LogMAR), eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Lithuanian University of Health Sciences, status: RECRUITING, city: Kaunas, zip: LT-44307, country: Lithuania, contacts name: Reda Zemaitiene, role: CONTACT, phone: + 370 37 327 201, email: rektoratas@lsmu.lt, geoPoint lat: 54.90272, lon: 23.90961, hasResults: False
protocolSection identificationModule nctId: NCT06298851, orgStudyIdInfo id: E-10840098-772.02-2026, briefTitle: Comparative Effects of Lower Body Quadrant Neural Mobilization and Stretching in Collegiate Football Players, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-08, primaryCompletionDateStruct date: 2024-03-25, completionDateStruct date: 2024-03-31, studyFirstPostDateStruct date: 2024-03-07, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Istanbul Medipol University Hospital, class: OTHER, descriptionModule briefSummary: Neural mobilizations (NM) are defined as interventions that aim to directly or indirectly affect neural structures or surrounding tissue through manual techniques or exercise. Neural mobilizations have been studied in both patients and healthy populations. In the study, individuals in the amateur football team will be divided into three groups and will be given pre-training warm-up periods, including neural mobilization, dynamic and static stretching.After the warm-up period, its effect on flexibility and performance will be examined and compared., conditionsModule conditions: Sports Physical Therapy, conditions: Stretch, conditions: Stretch Injury, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Neural Mobilization Group (NMG), interventions name: Dynamic Stretching Group (DSG), interventions name: Static Stretching Group (SSG), outcomesModule primaryOutcomes measure: Straight Leg Raise Test, secondaryOutcomes measure: Y Balance Test, otherOutcomes measure: One-Leg Forward Jump Test, otherOutcomes measure: T Test, otherOutcomes measure: BlazePod Reaction Time Determination Test, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 25 Years, stdAges: ADULT, contactsLocationsModule locations facility: Istanbul Medipol University, city: Istanbul, zip: 34820, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06298838, orgStudyIdInfo id: XEOS study, briefTitle: High-resolution Intra-operative PSMA PET-CT in Prostate Cancer, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2025-03, completionDateStruct date: 2025-03, studyFirstPostDateStruct date: 2024-03-07, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: IRCCS San Raffaele, class: OTHER, descriptionModule briefSummary: This is a Single-center, diagnostic open-label prospective, pilot study in a total of 10 patients affected by Prostate cancer (PCa) with a risk of lymph node invasion (LNI) higher than 5% and candidates for a robot-assisted radical prostatectomy (RARP) with an extended pelvic lymph node dissection (ePLND) .The aim of the trial is to evaluate the feasibility and accuracy and clinical value of a novel high-resolution perioperative PET-CT-scan for intraoperative margin and lymph node invasion assessment, after 18F-PSMA injection, using histopathology as the gold standard., conditionsModule conditions: Prostate Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: AURA10® Specimen PET/CT imager, outcomesModule primaryOutcomes measure: To investigate the performance characteristics (sensitivity and specificity) of a novel high-resolution perioperative PET-CT-scan for intraoperative margins and lymph node invasion assessment after 18F-PSMA using histopathology as the gold standard, secondaryOutcomes measure: Reporting positive lymph nodes detection rate at intraoperative imaging after 18-PSMA injection, eligibilityModule sex: MALE, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06298825, orgStudyIdInfo id: KY2024-148, briefTitle: S-ADHF：Sarcopenia in Patients With ADHF, acronym: S-ADHF, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2025-12-01, completionDateStruct date: 2026-06-01, studyFirstPostDateStruct date: 2024-03-07, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: Guangdong Provincial People's Hospital, class: OTHER, descriptionModule briefSummary: This is a prospective, multi-center, investigator-initiated observational cohort study. Enrollment with a minimum of of 195 cases each for patients with and without sarcopenia. Each patient is followed up for 6 month, 1 year, 2 years or until the occurrence of death.This study will examine the correlation between sarcopenia and prognosis in different subgroups of patients, and explore the additive effect of different comorbidities and sarcopenia on prognosis in patients with acute decompensated heart failure., conditionsModule conditions: Acute Decompensated Heart Failure, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 500, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: All-cause mortality, secondaryOutcomes measure: All-cause mortality, secondaryOutcomes measure: Cardiovascular mortality, secondaryOutcomes measure: All-cause hospitalisation, secondaryOutcomes measure: HF hospitalisation, otherOutcomes measure: The frequency and length of hospitalization of patient readmitted, otherOutcomes measure: Survival time from enrollment to death of deceased patients, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Huan Ma, city: Guangdong, country: China, contacts name: Huan Ma, PhD, role: CONTACT, phone: +86 15078755932, email: mahuandoctor@163.com, hasResults: False
protocolSection identificationModule nctId: NCT06298812, orgStudyIdInfo id: Protocol Rev 0 11July2023, briefTitle: REFLECT Scoliosis System Post Approval Study, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-31, primaryCompletionDateStruct date: 2027-03-31, completionDateStruct date: 2032-03-31, studyFirstPostDateStruct date: 2024-03-07, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Globus Medical Inc, class: INDUSTRY, descriptionModule briefSummary: The purpose of this multi-center, prospective, single-arm registry Post-Approval Study (PAS) is to evaluate the radiographic and clinical outcomes of 100 patients with idiopathic scoliosis treated with the REFLECT™ Scoliosis Correction System, as a condition of HDE approval, conditionsModule conditions: Idiopathic Scoliosis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Patients treated with the REFLECT Scoliosis Correction System, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: REFLECT Scoliosis Correction System, outcomesModule primaryOutcomes measure: Primary Probable Benefit, primaryOutcomes measure: Primary Safety, secondaryOutcomes measure: Curve progression, secondaryOutcomes measure: Device integrity, secondaryOutcomes measure: Composite endpoint analysis, secondaryOutcomes measure: Failure analysis, secondaryOutcomes measure: SRS score, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Mayo Clinic, city: Rochester, state: Minnesota, zip: 55905, country: United States, contacts name: Jana Robinson, role: CONTACT, contacts name: Noelle Larson, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.02163, lon: -92.4699, hasResults: False
protocolSection identificationModule nctId: NCT06298799, orgStudyIdInfo id: GEN-GE-001-IL, briefTitle: GENETIC VARIABILITY TO GLP1 TREATMENT, acronym: GLP1 treatment, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-10-01, primaryCompletionDateStruct date: 2025-01-01, completionDateStruct date: 2025-01-01, studyFirstPostDateStruct date: 2024-03-07, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: GENGE, class: OTHER, descriptionModule briefSummary: The goal of this retrospective study is to assess whether a selection of genetic variants may allow us to identify individuals who will have a satisfactory response after GLP-1 treatment in terms of weight loss, sugar level reduction, and adverse events.Participants will The study consists of a single visit at the diabetes unit clinic at the involved study sites. The following will be performed for every subject at the study screening enrollment visit:* Informed consent* Study eligibility (Inclusion / Exclusion criteria)* Collection of demographic data (age (date of birth), gender, ethnic origin)* General and T2DM medical history review (per subject file)* Concomitant medication review (at enrollment)* Physical attributes (Body Weight, Height, BMI)* Allocation to study cohort and study subgroup* Saliva and blood collection for genetic tests* Self-reported questionnaire for Ozempic (Semaglutide) experience, conditionsModule conditions: Type 2 Diabetes, conditions: Obesity, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: The study population consists of two cohorts:A. Type 2 Diabetic participants cohort B. Healthy participants cohort, primaryPurpose: OTHER, maskingInfo masking: NONE, maskingDescription: no masking, enrollmentInfo count: 400, type: ESTIMATED, armsInterventionsModule interventions name: DNA Sequencing and Analysis, interventions name: differential expression analysis with RNA-sequencing (RNA seq) experiments, outcomesModule primaryOutcomes measure: Genetic variants and miRNA expressions associated with changes in BMI., secondaryOutcomes measure: Genetic variants and miRNA expressions associated with changes in A1c., otherOutcomes measure: Genetic variants and miRNA expressions associated with side effects., otherOutcomes measure: Demographic parameters that affect GLP1 AG therapy., eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Rambem medical center, status: RECRUITING, city: Haifa, country: Israel, contacts name: Irit Hochberg, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 32.81841, lon: 34.9885, hasResults: False
protocolSection identificationModule nctId: NCT06298773, orgStudyIdInfo id: 6127, briefTitle: Spatial Profile of Tumors, acronym: PROST, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-05, primaryCompletionDateStruct date: 2026-09-30, completionDateStruct date: 2028-12-30, studyFirstPostDateStruct date: 2024-03-07, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS, class: OTHER, descriptionModule briefSummary: The research project focuses on analyzing the spatial organization of cells within various solid tumors, utilizing advanced technologies enabling in-depth multi-parametric analysis of tumor and immune cells. The primary objective is to understand the spatial distribution of cellular subpopulations within each type of tumor, while secondary objectives include correlating these data with clinical aspects and identifying potential therapeutic targets. The study involves 1000 patients with primary or metastatic tumors and spans a duration of 5 years, from 2024 to 2028. No experimental treatments are planned; rather, only spatial imaging analyses with multiple markers will be conducted. Data analysis involves descriptive statistical methods and hypothesis testing to generate hypotheses for subsequent studies. The analyses will be performed using SPSS® version 21.0 software for Windows®., conditionsModule conditions: Solid Tumors, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 1000, type: ESTIMATED, armsInterventionsModule interventions name: Spatial analysis of paraffin samples from solid tumors, outcomesModule primaryOutcomes measure: Spatial analysis of cancer cells, secondaryOutcomes measure: Comparison of clinical data, secondaryOutcomes measure: Identification of therapeutic targets, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS, city: Rome, state: RM, zip: 00168, country: Italy, contacts name: Alessandro Sgambato, role: CONTACT, phone: +390630154914, email: alessandro.sgambato@policlinicogemelli.it, contacts name: Alessandro Sgambato, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.89193, lon: 12.51133, hasResults: False
protocolSection identificationModule nctId: NCT06298760, orgStudyIdInfo id: çörekotu refleksoloji, briefTitle: The Effect of Reflexology and Knee Massage With Black Cumin Oil on Pain and Fatigue, statusModule overallStatus: COMPLETED, startDateStruct date: 2019-06-19, primaryCompletionDateStruct date: 2020-02-19, completionDateStruct date: 2020-04-19, studyFirstPostDateStruct date: 2024-03-07, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: Erzurum Technical University, class: OTHER, descriptionModule briefSummary: In this study, black cumin extract oil was used in elderly individuals with Knee Osteoarthritis (OA). The effects of foot reflexology and knee massage on pain and fatigue symptoms. It is aimed to examine and research which of these two applications is more effective.The study, planned as a randomized controlled experimental study, included a total of 150 participants.The data consists of participants who receive outpatient treatment in the Physical Therapy and Rehabilitation Unit at a university hospital, are over 65 years old, and have no problems with their perception after the Mini Mental Test. After randomization, participants were divided into five groups, with 30 participants in each group. Groups; It consisted of 1) Reflexology with Black Cumin, 2) Placebo Reflexology, 3) Knee Massage with Black Cumin, 4) Placebo Knee Massage and 5) Control groups., conditionsModule conditions: Knee Osteoarthritis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: After randomization, participants were divided into 30 participants in each group.were divided into five groups:Groups; It consisted of 1) Reflexology with Black Cumin, 2) Placebo Reflexology, 3) Knee Massage with Black Cumin, 4) Placebo Knee Massage and 5) Control groups. "Patient Information Form", "Kellgren and Lawrence", "Pain Visual Analog Scale (A-VAS)", "Fatigue Severity Scale and Western Ontario and McMaster Universities Osteoarthritis Index "WOMAC" were applied to the participants. Participants in the application groups were administered once a week for 6 weeks. The session lasted 30 minutes. The control group was allowed to continue routine treatment and care without any intervention. Data were collected by applying questionnaires to the participants in the 1st and 6th weeks., primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 150, type: ACTUAL, armsInterventionsModule interventions name: Knee Massage With Black Cumin Oil Group:, interventions name: Foot Reflexology Group With Black Cumin Oil, interventions name: placebo group, outcomesModule primaryOutcomes measure: Pain Score, secondaryOutcomes measure: fatigue severity, eligibilityModule sex: ALL, minimumAge: 65 Years, maximumAge: 90 Years, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Ercan Bakır, city: Erzurum, state: Yakutiye, country: Turkey, geoPoint lat: 39.90861, lon: 41.27694, hasResults: False