protocolSection identificationModule nctId: NCT06303180, orgStudyIdInfo id: 10001560, secondaryIdInfos id: 001560-DC, briefTitle: NIDCD Otolaryngology Clinical Protocol Biospecimen Bank, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-04, primaryCompletionDateStruct date: 2033-12-30, completionDateStruct date: 2033-12-30, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: National Institute on Deafness and Other Communication Disorders (NIDCD), class: NIH, descriptionModule briefSummary: Background:Many disorders of the head and neck can affect a person s hearing; balance; smell; taste; swallowing; voice; or speech. These disorders include cancers and genetic and inflammatory diseases. To find better ways to diagnose and treat these disorders, researchers need to study tissues and other biological samples from people who have them.Objective:To collect biological samples for a repository that will be used for research.Eligibility:People of any age with a disorder of the head and neck that requires the taking of biological samples. The conditions may be any that affect hearing; balance; smell; taste; swallowing; voice; or speech.Design:Part 1: Participants will give permission for their leftover tissue samples to be used for research. These are tissue samples from the head and neck that were collected in the course of routine tests and care or other research studies. Information on each participant s age, diagnosis, and previous treatments will also be collected.Part 2: Some participants may be asked for more samples. All those aged 3 years or older will have a physical exam. They will provide blood and saliva samples. A cotton swab or brush will be used to collect cells from the inside of the cheek.Participants 18 years or older may have additional tests. They may provide nasal secretions: A piece of gelfoam or a sponge will be placed in the nose to soak up secretions for 5 to 10 minutes. They may have biopsies: Small samples of tissue will be cut from the skin and the tissue lining the mouth.Samples may be used for genetic testing., conditionsModule conditions: Hearing Loss, conditions: Head and Neck Neoplasms, conditions: Hearing Disorders, conditions: Laryngeal Disease, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 1000, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: To create a biorepository of diseased and normal tissue specimens for research purposes., secondaryOutcomes measure: To share specimens with the NCI Frederick Patient-Derived Xenograft (PDX) team, other approved protocols or may be used under this protocol to conduct analysis of cellular, molecular, genetic and genomic biology of, eligibilityModule sex: ALL, minimumAge: 3 Years, maximumAge: 99 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: National Institutes of Health Clinical Center, status: RECRUITING, city: Bethesda, state: Maryland, zip: 20892, country: United States, contacts name: Marcia Mulquin, RN, MSN, role: CONTACT, phone: 301-496-1601, email: mmulquin@mail.nih.gov, contacts name: NIH Clinical Center Office of Patient Recruitment (OPR), role: CONTACT, phone: (800) 411-1222, phoneExt: TTY dial 711, email: ccopr@nih.gov, geoPoint lat: 38.98067, lon: -77.10026, hasResults: False