hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06384846, orgStudyIdInfo id: AI ACS, briefTitle: AI Algorithms in Prediction of ACS Based on Leukocyte Properties, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-01, primaryCompletionDateStruct date: 2026-07-31, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: RobotDreams GmbH, class: INDUSTRY, descriptionModule briefSummary: The goal of this observational study is to find out if artificial intelligence (AI) can accurately predict acute coronary syndrome (ACS) using data on white blood cells in adults. The main question it aims to answer is:- Can AI algorithms based on white blood cell data predict ACS with accuracy comparable to that of high-sensitivity cardiac troponin (hs-cTn)? Researchers will look at how the AI model's predictions stack up against the standard hs-cTn blood tests to see which is more accurate in diagnosing ACS.Participants in this study will have already had blood tests as part of their usual care. Their previously collected health information and blood test results will be used to help train and test the AI algorithms. Participants will not undergo any new procedures for the study itself., conditionsModule conditions: Acute Coronary Syndrome, conditions: Angina Pectoris, conditions: NSTEMI - Non-ST Segment Elevation MI, conditions: STEMI - ST Elevation Myocardial Infarction, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 2700, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Training of AI models, primaryOutcomes measure: Testing of AI models, secondaryOutcomes measure: Training of AI models, secondaryOutcomes measure: Testing of AI models:, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Landeskrankenhaus-Universitätsklinikum Graz, status: RECRUITING, city: Graz, state: Styria / Steiermark, zip: 8036, country: Austria, contacts name: Heiko Bugger, MD, role: CONTACT, phone: +43 316 385 30177, email: heiko.bugger@medunigraz.at, geoPoint lat: 47.06667, lon: 15.45, hasResults: False
protocolSection identificationModule nctId: NCT06384833, orgStudyIdInfo id: Rama, briefTitle: Combination of Vitamin C and N-Acetylcysteine to Improve Functional Outcome After Rotator Cuff Repair, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-09-01, completionDateStruct date: 2026-05-01, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: Mahidol University, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to learn if vitamin C and N-acetylcysteine work to improve shoulder functional score after rotator cuff repair. It will also learn about the safety of vitamin C and N-acetylcysteine. The main questions it aims to answer are:Do vitamin C and N-acetylcysteine improve the shoulder functional score of participants? Do vitamin C and N-acetylcysteine improve healing of rotator tendon? Researchers will compare vitamin C and N-acetylcysteine to a placebo (a look-alike substance that contains no drug) to see if vitamin C and N-acetylcysteine works to improve shoulder functional score after rotator cuff repair.Participants will:Take vitamin C and N-acetylcysteine or a placebo every day for 45 days. Visit the OPD three times at 2 week, 6 month and 12 month after surgery for checkups and tests., conditionsModule conditions: Rotator Cuff Tears, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 110, type: ESTIMATED, armsInterventionsModule interventions name: Ascorbic acid, interventions name: N-acetyl cysteine, interventions name: placebo, outcomesModule primaryOutcomes measure: ASES score, secondaryOutcomes measure: UCLA shoulder scale, secondaryOutcomes measure: WORC index, secondaryOutcomes measure: Tendon healing at 6 months postoperatively, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06384807, orgStudyIdInfo id: BHV1510-101 (PBI-410-101), briefTitle: A Phase 1/2 Study of PBI-410 in Advanced Solid Tumors, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2028-02, completionDateStruct date: 2028-02, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: Pyramid Biosciences, class: INDUSTRY, descriptionModule briefSummary: This is a Phase 1/2, first in human (FIH), open-label, multicenter study of PBI-410 in participants with previously treated, advanced solid tumors., conditionsModule conditions: Solid Tumor, designModule studyType: INTERVENTIONAL, phases: PHASE1, phases: PHASE2, designInfo allocation: NA, interventionModel: SEQUENTIAL, interventionModelDescription: Dose escalation followed by enrollment in signal-finding cohorts., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 170, type: ESTIMATED, armsInterventionsModule interventions name: PBI-410, outcomesModule primaryOutcomes measure: Phase 1: Number of patients with adverse events (AEs), primaryOutcomes measure: Phase 1: Recommended dose for expansion (RDE) and maximum tolerated dose (MTD), primaryOutcomes measure: Phase 2: Objective Response Rate (ORR), primaryOutcomes measure: Phase 2: Number of patients with AEs, primaryOutcomes measure: Phase 2: Duration of Response (DoR), secondaryOutcomes measure: Phase 1 and 2: Maximum Plasma Concentration (Cmax) of PBI-410, secondaryOutcomes measure: Phase 1 and 2: Area Under the Concentration versus time Curve (AUClast) from the end of infusion to the last measurable concentration of PBI-410, secondaryOutcomes measure: Phase 1 and 2: Area Under the Concentration versus time curve extrapolated to infinity (AUCinf), secondaryOutcomes measure: Phase 1 and 2: Elimination half-life (t1/2) of PBI-410 in plasma, secondaryOutcomes measure: Phase 1: ORR, secondaryOutcomes measure: Phase 1: Duration of Response (DoR), secondaryOutcomes measure: Phase 1 and 2: Immunogenicity of PBI-410, secondaryOutcomes measure: Phase 2: Disease control rate (DCR), secondaryOutcomes measure: Phase 2: Progression free survival (PFS), secondaryOutcomes measure: Phase 2: Overall survival (OS), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06384768, orgStudyIdInfo id: EBIst, secondaryIdInfos id: 1919B012104428, type: OTHER_GRANT, domain: TUBITAK, briefTitle: Video Training on Pre-Pregnancy Fear of Birth in Male Partners, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-02-01, primaryCompletionDateStruct date: 2022-05-01, completionDateStruct date: 2022-08-30, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Istanbul University - Cerrahpasa (IUC), class: OTHER, descriptionModule briefSummary: This study aimed to evaluate the effect of an online video training on fears surrounding childbirth given to male partners before the pregnancy of their spouses. The study conducted with 43 male (22 intervention; 21 control) participants. Participants were divided into intervention and control groups. The intervention group was given video training on pregnancy and the birth process. \&#34;Descriptive Information Form\&#34; and the "Male-Childbirth Fear Prior to Pregnancy Scale" was used for data collection. Before the intervention, it was found that the fear level of childbirth was low. The video training given to male partners before the pregnancy of their spouses diminished the fear of birth but did not create a significant difference. These findings support long-term training that includes video tutorials for parents before birth. Interactive, participatory birth preparation training is likely to enhance the training's appeal for male partners., conditionsModule conditions: Fear of Childbirth, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 43, type: ACTUAL, armsInterventionsModule interventions name: Video training, outcomesModule primaryOutcomes measure: Fear of Childbirth, eligibilityModule sex: MALE, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Istinye University, city: Istanbul, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06384742, orgStudyIdInfo id: K23HL157698, type: NIH, link: https://reporter.nih.gov/quickSearch/K23HL157698, briefTitle: Shift Worker Intervention for Sleep Health, acronym: SWISH, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-09, primaryCompletionDateStruct date: 2026-09, completionDateStruct date: 2027-03, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: Oregon State University, class: OTHER, collaborators name: National Heart, Lung, and Blood Institute (NHLBI), descriptionModule briefSummary: The aim of this study is to pilot test a comprehensive, personalized, media-augmented telehealth intervention ("SWISH") designed to improve sleep health among shift workers., conditionsModule conditions: Shift Work Type Circadian Rhythm Sleep Disorder, conditions: Insomnia, Psychophysiological, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: Participants are asked to refrain from mentioning any information about the treatment they receive when interacting with the investigator or outcomes assessors. Participants are asked not to share details of their treatment with other individuals at their workplace., whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Shift Worker Intervention for Sleep Health, outcomesModule primaryOutcomes measure: Retention Rate, primaryOutcomes measure: Session Attendance, primaryOutcomes measure: Implementation Assessment Measure, secondaryOutcomes measure: Patient Adherence, secondaryOutcomes measure: Therapist Fidelity, secondaryOutcomes measure: Acceptability of Study Procedures and SWISH, secondaryOutcomes measure: Mean 24-hour sleep duration and efficiency, secondaryOutcomes measure: Change in Fatigue Severity Scale, secondaryOutcomes measure: Change in Epworth Sleepiness Scale, secondaryOutcomes measure: Executive functioning, secondaryOutcomes measure: PROMIS Sleep Related Impairment, secondaryOutcomes measure: PROMIS Sleep Disturbances, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Oregon State University, city: Corvallis, state: Oregon, zip: 97331-1102, country: United States, contacts name: Jessee Dietch, PhD, role: CONTACT, phone: 541-737-1358, email: jessee.dietch@oregonstate.edu, contacts name: Jessee Dietch, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 44.56457, lon: -123.26204, hasResults: False
protocolSection identificationModule nctId: NCT06384703, orgStudyIdInfo id: 201518015, briefTitle: The Relationship Between Microbiota and Coronary Ectasia, statusModule overallStatus: COMPLETED, startDateStruct date: 2020-11-03, primaryCompletionDateStruct date: 2021-04-25, completionDateStruct date: 2021-06-18, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: Konya Beyhekim Training and Research Hospital, class: OTHER_GOV, collaborators name: Necmettin Erbakan University, descriptionModule briefSummary: Introduction: It is now known that the microbiota is far beyond the microbial communities living in certain parts of our body and functions like a metabolic organ. In addition, the microbiota, through its metabolites, is involved in the pathophysiology or progression of a wide range of diseases, from atherosclerotic diseases to metabolic diseases and even neurological diseases. Among these metabolites, trimethylamine n-oxide metabolite has been shown to be particularly effective on atherosclerotic heart diseases., conditionsModule conditions: Coronary Ectasia, conditions: Microbial Disease, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 2, type: ACTUAL, armsInterventionsModule interventions name: Taking blood for kit study, outcomesModule primaryOutcomes measure: death, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Necmettin Erbakan University, city: Konya, zip: 42050, country: Turkey, geoPoint lat: 37.87135, lon: 32.48464, hasResults: False
protocolSection identificationModule nctId: NCT06384677, orgStudyIdInfo id: 03.03.2023/371, briefTitle: Comparison of Postoperative Analgesia Methods in Patients Undergoing Major Intraabdominal Surgery, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-04-20, primaryCompletionDateStruct date: 2024-02-01, completionDateStruct date: 2024-02-01, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: Marmara University, class: OTHER, descriptionModule briefSummary: This study aims to examine the effects of M-TAPA applied for postoperative analgesia in patients who had major intraabdominal surgery on the postoperative pain score, the change in the postoperative total opioid requirement and the side effects., conditionsModule conditions: Abdominal Cancer, conditions: Abdomen Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 43, type: ACTUAL, armsInterventionsModule interventions name: M-Tapa Block, outcomesModule primaryOutcomes measure: Opioid Consumption, secondaryOutcomes measure: NRS Scores, secondaryOutcomes measure: the need for rescue analgesia, secondaryOutcomes measure: side effects, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Marmara University Pendik Research and Training Hospital, city: Istanbul, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06384664, orgStudyIdInfo id: HUM00241242, briefTitle: Cryoablation Effects on Acute and Chronic Pain After Thoracotomy and Thoracoscopy, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2027-04, completionDateStruct date: 2028-04, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: University of Michigan, class: OTHER, collaborators name: AtriCure, Inc., descriptionModule briefSummary: The researchers will compare the common methods of post-surgical pain control, such as epidural or intercostal nerve block with a newer method called cryoablation. The research team is conducting this study to determine if cryoablation provides more effective pain control when compared to an epidural or intercostal nerve block., conditionsModule conditions: Pain, Postoperative, conditions: Intrathoracic Procedure, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Atricure's crysoSPHERE probe, interventions name: Standard of Care, outcomesModule primaryOutcomes measure: Severity of pain in the peri-operative period, primaryOutcomes measure: Inflammatory cytokine levels as measured by blood samples, primaryOutcomes measure: Inflammatory cytokines (IL-1, IL-6, TNF-a) levels correlations to pain score, primaryOutcomes measure: Peri-operative pain scores between different surgical incisions (posterolateral thoracotomy vs thoracoscopy), primaryOutcomes measure: Peri-operative nerve function between different surgical incisions (posterolateral thoracotomy vs thoracoscopy), secondaryOutcomes measure: Quality of life score as measured by SF-36 Health questionnaire, secondaryOutcomes measure: Cost (including postoperative epidural management, narcotic pain medication, and outpatient pain management), secondaryOutcomes measure: Workflow/time, otherOutcomes measure: Complications following surgery, otherOutcomes measure: Length of stay, otherOutcomes measure: Time to ambulation, otherOutcomes measure: Chronic Pain medication use through 6 months, otherOutcomes measure: Chronic pain through 6 months., otherOutcomes measure: Chronic pain through 6 months., otherOutcomes measure: Chronic pain through 6 months., otherOutcomes measure: Incentive spirometry volumes in the peri-operative period (POD 1 and 2), otherOutcomes measure: Oxygen requirement, otherOutcomes measure: Hospital charges and hospital reimbursement by different payors, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Michigan, city: Ann Arbor, state: Michigan, zip: 48109, country: United States, contacts name: Shari L Barnett, role: CONTACT, phone: 734-936-4561, email: shbailey@umich.edu, contacts name: Rishindra Reddy, MD, MBA, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.27756, lon: -83.74088, hasResults: False
protocolSection identificationModule nctId: NCT06384651, orgStudyIdInfo id: PRO00037789, briefTitle: Intraosseous vs. Intravenous Vancomycin Administration in Total Ankle Arthroplasty, acronym: IOTAA, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-13, primaryCompletionDateStruct date: 2027-04, completionDateStruct date: 2027-12, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: The Methodist Hospital Research Institute, class: OTHER, descriptionModule briefSummary: The purpose of this study is to compare two different antibiotic regimens and techniques during total ankle arthroplasty (TAA).Primary Objective: Comparable levels of vancomycin will be found in bone, soft tissue, and systemic samples between patient groups.Secondary Objective: Compare 30 day and 90 day post-operative complication rates (infection) between the control (standard IV administration of vancomycin) vs the interventional group (intraosseous administration of vancomycin). The investigators hypothesize that there will be no difference in complication (infection) rates between groups., conditionsModule conditions: Infections, conditions: Ankle Arthritis, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: This study is a prospective, randomized, single-blinded, controlled trial. 20 patients in each treatment arm: 20 patients will be given IV vancomycin, 20 patients will be given IO vancomycin, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: single blind patient is blinded. Surgeon is not blinded. Lab technician measuring tissue concentrations are blinded. Research coordinator is not blinded., whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Intraosseous Vancomycin Injection, interventions name: Intravenous Vancomycin, outcomesModule primaryOutcomes measure: Systemic Sample Vancomycin Tissue Concentration - Start of Case, primaryOutcomes measure: Systemic Sample Vancomycin Tissue Concentration - End of Case, primaryOutcomes measure: Capsule or Synovium Sample Vancomycin Tissue Concentration, primaryOutcomes measure: Distal Tibia Sample Vancomycin Tissue Concentration, primaryOutcomes measure: Talar Bone Sample Vancomycin Tissue Concentration, secondaryOutcomes measure: 90 day post-operative wound complication and infection rates, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Houston Methodist Hospital, status: RECRUITING, city: Houston, state: Texas, zip: 77030, country: United States, contacts name: Thomas C Sullivan, BS, role: CONTACT, phone: 346-238-1603, email: tsullivan@houstonmethodist.org, contacts name: Jason S Ahuero, MD, role: PRINCIPAL_INVESTIGATOR, contacts name: Kevin Varner, MD, role: SUB_INVESTIGATOR, contacts name: Kwan J Park, MD, role: SUB_INVESTIGATOR, geoPoint lat: 29.76328, lon: -95.36327, hasResults: False
protocolSection identificationModule nctId: NCT06384638, orgStudyIdInfo id: coconut periodontitis, briefTitle: Coconut Oil in Treatment of Periodontitis, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-02-15, primaryCompletionDateStruct date: 2024-01-16, completionDateStruct date: 2024-02-09, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: Misr University for Science and Technology, class: OTHER, descriptionModule briefSummary: Virgin Coconut Oil (VCO) is a vegetable oil extracted from coconut fleshcontains unsaturated fatty acids in the form of oleic acid and linoleic acid and flavonoids which function as anti-inflammatory. Periodontitis is an inflammatory disease of the periodontal tissues with a high prevalence worldwide. The main etiology of plaque periodontitis is biofilm containing colonies of pathogenic microorganisms. The aim of the study is to evaluate and compare the effect of scaling and root debridement alone versus the use of topically applied coconut oil as adjunctive to scaling and root debridement in treatment of Stage II and III Grade B periodontitis., conditionsModule conditions: Periodontal Diseases, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: CARE_PROVIDER, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 34, type: ACTUAL, armsInterventionsModule interventions name: topical application of coconut oil, interventions name: scaling and debridement, outcomesModule primaryOutcomes measure: clinical parameters, primaryOutcomes measure: clinical parameters, secondaryOutcomes measure: Biological parameters, eligibilityModule sex: ALL, minimumAge: 35 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Faculty of dentistry at MUST, city: Giza, zip: 02, country: Egypt, geoPoint lat: 30.00808, lon: 31.21093, hasResults: False