protocolSection identificationModule nctId: NCT06262711, orgStudyIdInfo id: 321917, briefTitle: Effects of Vitamin C on Skeletal Muscle, acronym: VICS, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-02, primaryCompletionDateStruct date: 2025-03, completionDateStruct date: 2025-03, studyFirstPostDateStruct date: 2024-02-16, lastUpdatePostDateStruct date: 2024-02-16, sponsorCollaboratorsModule leadSponsor name: University of East Anglia, class: OTHER, collaborators name: The Norfolk and Norwich University Hospitals NHS Foundation Trust, collaborators name: The Quadram Institute Clinical Research Facility, descriptionModule briefSummary: As part of the ageing process muscles become weaker. One of the reasons for this is that mitochondria, the 'engines' that provide energy to fuel muscles, age and work less efficiently. Mitochondria are found in almost all cells in the human body. Mitochondria take in nutrients that are provided from food and break these down to create energy-rich compounds to fuel many different processes in the body. Muscles are loaded with mitochondria because they require a lot of energy. Mitochondria naturally produce small compounds called oxidants that can damage muscle cells and can cause inflammation. The cells in the body have a natural defence system to protect against oxidants, but when mitochondria age and become less efficient, the amount of oxidants that they produce can increase. These oxidants can damage muscles and the mitochondria themselves. Antioxidants, such as vitamin C, may help protect muscles from the damage caused by oxidants, and may help mitochondria work more efficiently. In this study, the investigators will explore whether vitamin C can help mitochondria work more efficiently, which may improve muscle strength, and help older people to remain mobile and independent for longer., conditionsModule conditions: Healthy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, interventionModelDescription: Crossover Assignment, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: TRIPLE, maskingDescription: Double blind masking, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 16, type: ESTIMATED, armsInterventionsModule interventions name: Vitamin C, interventions name: Placebo, outcomesModule primaryOutcomes measure: Difference in skeletal muscle mitochondrial function between vitamin C and placebo groups., secondaryOutcomes measure: Difference in skeletal muscle phosphomonoester to phosphodiester ratio (PME/PDE) between vitamin C and placebo groups., secondaryOutcomes measure: Difference in knee extension strength between vitamin C and placebo groups., secondaryOutcomes measure: Difference in hand grip strength between vitamin C and placebo groups., secondaryOutcomes measure: Difference in Short Physical Performance Battery (SPPB) score between vitamin C and placebo groups., secondaryOutcomes measure: Difference in plasma vitamin C between vitamin C and placebo groups., secondaryOutcomes measure: Difference in serum hs-CRP between vitamin C and placebo groups., secondaryOutcomes measure: Difference in serum IL-6 between vitamin C and placebo groups., secondaryOutcomes measure: Difference in serum TNF-α between vitamin C and placebo groups., secondaryOutcomes measure: Difference in plasma P1NP between vitamin C and placebo groups., secondaryOutcomes measure: Difference in plasma CTX between vitamin C and placebo groups., eligibilityModule sex: FEMALE, minimumAge: 65 Years, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of East Anglia, city: Norwich, state: Norfolk, zip: NR4 7TJ, country: United Kingdom, geoPoint lat: 52.62783, lon: 1.29834, hasResults: False