protocolSection identificationModule nctId: NCT06307743, orgStudyIdInfo id: RAPID-SAVE, briefTitle: Rapid Local Ischemic Postconditioning in Acute Ischemic Stroke, acronym: RAPID-SAVE, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-15, primaryCompletionDateStruct date: 2025-06-15, completionDateStruct date: 2025-09-15, studyFirstPostDateStruct date: 2024-03-13, lastUpdatePostDateStruct date: 2024-03-13, sponsorCollaboratorsModule leadSponsor name: Shanghai Jiao Tong University Affiliated Sixth People's Hospital, class: OTHER, collaborators name: Zhangzhou Municipal Hospital of Fujian Province, collaborators name: Shanghai East Hospital, collaborators name: First People's Hospital of Hangzhou, collaborators name: RenJi Hospital, descriptionModule briefSummary: The objective of this clinical trial is to determine whether rapid local ischemic postconditioning (RL-IPostC) is effective in preventing brain edema and safe in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy. In this trial, researchers will block antegrade cerebral blood flow temporarily by the way of balloon inflation/deflation in AIS patients immediately after revascularization. It makes the ischemic reperfusion brain tissue have a capacity of adaptation through intermittent blood flow restoration. Researchers will evaluate the protective role and safety of different duration of balloon inflation/deflation. The optimal postconditioning intervention dose will be determined for further confirmative investigation., conditionsModule conditions: Acute Ischemic Stroke, conditions: Mechanical Thrombectomy, conditions: Ischemic Postconditioning, conditions: Brain Edema, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: SEQUENTIAL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 135, type: ESTIMATED, armsInterventionsModule interventions name: rapid local ischemic postconditioning, outcomesModule primaryOutcomes measure: Number of Participants without clinically meaningful cerebral swelling, significant increase in infarct volume from baseline and intervention-related serious adverse events., secondaryOutcomes measure: Rate of participants without clinically meaningful cerebral swelling, secondaryOutcomes measure: Rate of participants with significant increase in infarct volume from baseline or intervention-related serious adverse events., secondaryOutcomes measure: Change in volume of cerebrospinal fluid (∆CSF72) at 72 hours, secondaryOutcomes measure: Change of net water uptake (∆NWU24) at 24 hours, secondaryOutcomes measure: Change of net water uptake (∆NWU72) at 72 hours, secondaryOutcomes measure: Midline shift at 24 hours, secondaryOutcomes measure: Midline shift at 72 hours, secondaryOutcomes measure: Change of NIHSS at 24 hours, secondaryOutcomes measure: Early therapeutic response to treatment, secondaryOutcomes measure: Good outcome at 90 days, secondaryOutcomes measure: Excellent outcome at 90 days, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 100 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False