protocolSection identificationModule nctId: NCT06265051, orgStudyIdInfo id: 100939, briefTitle: Tirofiban After Successful MT Recanalization in AIS, acronym: ATTRACTION, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2027-03-01, completionDateStruct date: 2027-09-01, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Xiang Luo, class: OTHER, collaborators name: Wuhan Central Hospital, collaborators name: Wuhan University, collaborators name: Renmin Hospital of Wuhan University, collaborators name: Second Affiliated Hospital of Soochow University, collaborators name: The First Affiliated Hospital of Zhengzhou University, collaborators name: Wuhan Hospital of Traditional Chinese Medicine, collaborators name: The Central Hospital of Enshi Tujia And Miao Autonomous Prefecture, collaborators name: Huangshi Central Hospital, China, collaborators name: The First Affiliated Hospital of Yangtze University, collaborators name: The Fifth Hospital of Wuhan, collaborators name: Wuhan Puren Hospital, collaborators name: Xiangyang No.1 People's Hospital, collaborators name: Xianning Central Hospital, collaborators name: Wuhan Hanyang Hospital, collaborators name: Wuhan Third Hospital, collaborators name: Yichang Central People's Hospital, collaborators name: Affiliated Hospital of Chengde Medical University, collaborators name: Beijing Tiantan Hospital, collaborators name: Nanyang Central Hospital, collaborators name: Jingzhou Central Hospital, collaborators name: Taihe Hospital, collaborators name: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, descriptionModule briefSummary: Acute ischemic stroke with large vessel occlusion is a frequently occurring life-threatening condition. Although endovascular treatment can effectively open occluded vessels, the successful reperfusion rate exceeds 80%, but the rate of good prognosis is less than 50%. The current clinical focus is on how to improve futile recanalization. Tirofiban is widely used in the treatment of stroke, as it can effectively prevent vascular reocclusion and improve microcirculation perfusion. It has the potential to improve futile recanalization, but there is a lack of high-level evidence-based medical support. This multicenter, prospective, double-blind, randomized controlled trial was conducted to assess the effectiveness and safety of sequential tirofiban therapy following successful mechanical thrombectomy within 24 hours of onset., conditionsModule conditions: Acute Ischemic Stroke, conditions: Vessel Occlusion, designModule studyType: INTERVENTIONAL, phases: PHASE2, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 1360, type: ESTIMATED, armsInterventionsModule interventions name: Tirofiban, interventions name: Saline placebo, outcomesModule primaryOutcomes measure: Proportion of patients functionally independent (mRS score 0 to 2) at 90 days, primaryOutcomes measure: Number of participants with symptomatic intracranial hemorrhage, secondaryOutcomes measure: Modified ranking scale (mRS), secondaryOutcomes measure: Proportion of patients non-disabled (mRS score 0 to 1) or return to pre-morbid mRS score at 90 days (for patients with mRS > 1), secondaryOutcomes measure: Proportion of patients ambulatory or bodily needs-capable or better (mRS score 0 to 3), secondaryOutcomes measure: Number of participants with improvement of neurological function, secondaryOutcomes measure: Health-related quality of life, assessed with the European Quality Five Dimensions Five Level scale (EQ-5D-5L), secondaryOutcomes measure: All-cause mortality, secondaryOutcomes measure: Proportion of intracranial hemorrhage of any type, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False