protocolSection identificationModule nctId: NCT06305221, orgStudyIdInfo id: opioid-free analgesia, briefTitle: Effect of Opioid-free Analgesia and Anesthesia on the Quality of Postoperative Recovery and Nausea Vomit in Patients Receiving Laparoscopic Sleeve Gastrectomy, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-09, primaryCompletionDateStruct date: 2025-03-31, completionDateStruct date: 2025-03-31, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-04-16, sponsorCollaboratorsModule leadSponsor name: Beijing Friendship Hospital, class: OTHER, descriptionModule briefSummary: The purpose of the intraoperative use of opioids is to reduce the amount of sedative medication and to ensure effective analgesia. But pain is an unpleasant sensory and emotional experience (a cognitive perception) that cannot occur with sufficient depth of anesthesia (even without opioids). So a more reasonable explanation for analgesia should be anti-nociception and the resulting inhibition of the response to surgical stress. Since multiple mediators are involved in nociceptive pathways, antinociception can also be acquired through multiple mechanisms. However, there is no single ideal harm drug to replace opioids, which often requires two or more drugs to meet clinical needs. While regional block attenuates the stress response to surgery and sympathetic activation because of afferents to block nociceptive stimuli, and has an important role in the implementation of OFA. Combined with the clinical characteristics of the LSG, investigators developed the transverse abdominis fascia block (transversus abdominis plane TAP) in combination with esketamine (esketamine), dexmedetomidine (dexmedetomidine, DEX) of opioid-free anesthesia (opioid free anesthesia, OFA) and the analgesic regimen (TEDOFA), Reduce patient pain scores, nausea and vomiting after LSG based on perfect analgesia and adequate anti-sympathetic response, As well as the other complications, Promote the accelerated postoperative recovery of patients undergoing LSG, And reduce the incidence and severity of postoperative chronic pain., conditionsModule conditions: Opioid-Free Anesthesia, conditions: Laparoscopic Sleeve Gastrectomy, conditions: Postoperative Vomiting, conditions: Postoperative Recovery, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 76, type: ESTIMATED, armsInterventionsModule interventions name: Opioid-free Analgesics (esketamine, dexmedetomidine), interventions name: Opioid Anesthetics (sufentanil and remifentanil), outcomesModule primaryOutcomes measure: 15-item recovery quality scale score 48 hours after surgery, primaryOutcomes measure: 15-item recovery quality scale score 24 hours before surgery, secondaryOutcomes measure: Dosage of postoperative analgesics, secondaryOutcomes measure: Duration of until postoperative PACU Aldrete score> 9 points, secondaryOutcomes measure: anesthesia-related complication, secondaryOutcomes measure: time to first exhaust gas after surgery, secondaryOutcomes measure: time of first postoperative mobilization, secondaryOutcomes measure: Overall benefit of analgesic score satisfaction in pain treatment, secondaryOutcomes measure: Acute pain numeric rating scale score, secondaryOutcomes measure: Rhodes Index of Nausea, Vomiting, and Retching, secondaryOutcomes measure: Rhodes Index of Nausea, Vomiting, and Retching, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: bijia Song, status: RECRUITING, city: Beijing, country: China, contacts name: bijia Song, role: CONTACT, phone: 18309845273, email: songbijia@163.com, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False