protocolSection identificationModule nctId: NCT06282705, orgStudyIdInfo id: 306347, briefTitle: Dose Response Effect of Drop Jumps on Bone Characteristics, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-01-06, primaryCompletionDateStruct date: 2023-12-13, completionDateStruct date: 2023-12-13, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Nottingham Trent University, class: OTHER, descriptionModule briefSummary: The study aims to assess if a 16-week drop jump intervention from different heights shows different bone adaptations. Participants will complete four visits over a period of 16 weeks. An initial consultation will be conducted to ensure participants meet the inclusion criteria following participant recruitment. Estimated load being applied to the bone, will be assessed using non-invasive biomechanical procedures (Inertial Measurement Units, motion analysis, force plates) during drop jumps. Participants will be assigned a drop jump height of 0 cm, 30 cm or 60 cm based on a significant difference in external load at these heights or assigned to a control group where no jumps will be performed. Groups will be matched for body mass to ensure that jump height produces the load. The participants will be asked to perform 40 jumps (20 each side), 4 times per week ensuring jumping bouts are separated by 24 hours. Bone characteristics will be assessed via whole body dual-energy X-ray absorptiometry (DXA) scans and bilateral peripheral Quantitative Computed Tomography (pQCT) scans. Lab based jumping will take place on week 0, week 6, week 12, and week 16 to understand the loading applied during the different jump height groups. pQCT scans will take place on week 0, week 12, week 16 and DXA scans will take place week 0 and week 16. The reasoning of week 12 for pQCT being it may show a significant timepoint for bone formation during the remodelling cycle. During visits participants will complete a health screen, the Bone specific Physical Activity Questionnaire (BPAQ), a food frequency questionnaire and Pittsburgh sleep quality questionnaire alongside consent as tools to monitor any changes to participant lifestyle across the study. Differences in bone characteristics, lab measures and jump heights will be analysed between and within participants.The present study aims to use varied drop jump heights to identify an osteogenic dose response effect. Drop jumps have been previously used to expose osteogenic effects in research due to the load produced at impact. Is it possible to identify an optimum height for bone response during impact? If so do we then find anything above this height actually has negative or no effect on a group of individuals?, conditionsModule conditions: Healthy Participants, conditions: Low Activity Level, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Semi-randomised, matched model., primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 48, type: ACTUAL, armsInterventionsModule interventions name: Diagonal Drop Jumps 0cm, interventions name: Diagonal Drop Jumps 40cm, interventions name: Diagonal Drop Jumps 60cm, outcomesModule primaryOutcomes measure: BMD as assessed by whole body dual-energy X-ray absorptiometry (DXA)., primaryOutcomes measure: BMC as assessed by whole body dual-energy X-ray absorptiometry (DXA)., primaryOutcomes measure: Total bone area as assessed by whole body dual-energy X-ray absorptiometry (DXA)., primaryOutcomes measure: Trabecular density as assessed by peripheral quantitative tomography (pQCT) of tibia., primaryOutcomes measure: Cortical thickness as assessed by peripheral quantitative tomography (pQCT) of tibia., primaryOutcomes measure: Periosteal circumference as assessed by peripheral quantitative tomography (pQCT) of tibia., primaryOutcomes measure: Axial bone strength (SSIX) as assessed by peripheral quantitative tomography (pQCT) of tibia., primaryOutcomes measure: Axial bone strength (SSIY) as assessed by peripheral quantitative tomography (pQCT) of tibia., primaryOutcomes measure: Polar bone strength (SSIPOL) as assessed by peripheral quantitative tomography (pQCT) of tibia., primaryOutcomes measure: Cortical density as assessed by peripheral quantitative tomography (pQCT) of tibia., secondaryOutcomes measure: Peak impact load as assessed by force plates., secondaryOutcomes measure: Impulse as assessed by force plates., secondaryOutcomes measure: Load rate as assessed by force plates., secondaryOutcomes measure: Jump height as assessed by force plates., secondaryOutcomes measure: Centre of Mass (CoM) velocity as assessed by force plates., secondaryOutcomes measure: Peak acceleration as assessed by Inertial measurement units (IMU)., secondaryOutcomes measure: Stiffness as assessed by motion capture., secondaryOutcomes measure: Moments as assessed by motion capture., eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 25 Years, stdAges: ADULT, contactsLocationsModule locations facility: Nottingham Trent University, city: Nottingham, state: Nottinghamshire, zip: Ng11 8NS, country: United Kingdom, geoPoint lat: 52.9536, lon: -1.15047, hasResults: False