hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06331260, orgStudyIdInfo id: CT2024-ZJU-OBS2, briefTitle: Assessment of AFP and PIVKA-II as Prognostic Indicators in Liver Transplantation for Hepatocellular Carcinoma, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2028-04-01, completionDateStruct date: 2028-04-01, studyFirstPostDateStruct date: 2024-03-26, lastUpdatePostDateStruct date: 2024-03-26, sponsorCollaboratorsModule leadSponsor name: Zhejiang University, class: OTHER, collaborators name: Shulan (Hangzhou) Hospital, descriptionModule briefSummary: As key biomarkers in HCC, AFP and PIVKA-II reflects biological features of tumor and has been widely applied for clinical diagnosis. Previous studies reported preoperative AFP and PIVKA-II are related to HCC recipient long-term survival after liver transplantation. However, there is no prospective study supporting these conclusions. This study aims to prospective collect liver transplantation cases from multiple transplant centers and further evaluate the prognostic role of preoperative AFP and PIVKA-II in liver transplantation for HCC., conditionsModule conditions: Liver Transplantation, conditions: Hepatocellular Carcinoma, conditions: Alpha-Fetoprotein, conditions: Protein Induced by Vitamin K Absence or Antagonist-II, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 600, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Recurrence free survival rate, primaryOutcomes measure: Overall survival rate, primaryOutcomes measure: Tumor recurrence rate, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06331234, orgStudyIdInfo id: VCI, briefTitle: Effects of Vena Cava Inferior Measurements on AKI and Mortality., statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2024-10-01, completionDateStruct date: 2024-12-01, studyFirstPostDateStruct date: 2024-03-26, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Inonu University, class: OTHER, descriptionModule briefSummary: Fluid overload is harmful in critically ill patients; In addition to increasing mortality, it may increase the incidence of acute kidney injury (AKI), length of ICU stay, and duration of mechanical ventilation by causing end-organ damage. (1-3) Mortality attributable to AKI is 20% and is an independent determinant of mortality. (4) Venous load ultrasonography score (VExUS) is a new systemic congestion scoring method based on inferior vena cava dilation and pulsed wave Doppler (PW-Doppler) morphology of the hepatic, portal and renal veins. It has been proposed as a score to assess systemic congestion. When the IVC diameter is \< 2 cm, it means there is no congestion and VEXUS is 0. Mild congestion: In addition to the IVC measuring approximately 2 cm, normal patterns such as the systolic wave being greater than the diastolic wave in the hepatic vein PW-doppler, pulsatility below 30% in the portal vein Doppler, continuous flow in the renal vein PW-doppler, or slightly abnormal patterns, i.e. hepatic The systolic wave in vein PW-doppler is smaller than the diastolic wave, the pulsatility in portal PW-doppler is between 30-50%, and the renal vein PW-doppler is accompanied by biphasic flow, and VEXUS is scored as 1. Moderate congestion is scored as VEXUS 2, which is measured as IVC 2 cm or more, plus inversion of the systolic wave on hepatic vein PW-doppler, pulsatility greater than 50% on portal PW-doppler, and discontinuous monophasic flow with only the diastolic phase on renal vein PW-doppler. It is accompanied by one of the serious abnormal patterns such as There is severe congestion, that is, VEXUS 3: IVC diameter of 2 cm or more and the presence of at least two seriously abnormal PW-Doppler morphologies. (5) The primary aim of this study is to describe the prevalence of venous congestion based on VExUS in general ICU patients. Secondary outcomes were to evaluate the association between VExUS, AKI, and 28-day mortality., conditionsModule conditions: Intensive Care Unit, conditions: Acute Kidney Injury, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Vena cava inferior diameter, outcomesModule primaryOutcomes measure: acute kidney injury, primaryOutcomes measure: mortality, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06331221, orgStudyIdInfo id: JSA_Fatigue_FADEUP, briefTitle: Effects of Different Concentric and Eccentric Muscle Fatigue Protocols on the Knee Joint Position Sense, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-02, primaryCompletionDateStruct date: 2024-05-15, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-03-26, lastUpdatePostDateStruct date: 2024-03-26, sponsorCollaboratorsModule leadSponsor name: Universidade do Porto, class: OTHER, descriptionModule briefSummary: The aim of this study was to investigate the effects of different concentric and eccentric muscle fatigue protocols on the knee joint position sense of healthy individuals., conditionsModule conditions: Healthy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Muscle fatigue Protocol, outcomesModule primaryOutcomes measure: Absolute angular error, primaryOutcomes measure: Relative angular error, primaryOutcomes measure: Variable angular error, eligibilityModule sex: MALE, minimumAge: 18 Years, maximumAge: 30 Years, stdAges: ADULT, contactsLocationsModule locations facility: Faculdade de Desporto, Universidade do Porto, status: RECRUITING, city: Porto, zip: 4200, country: Portugal, contacts name: Joana Azevedo, MSc, role: CONTACT, phone: +351917910094, email: azevedojoana311@gmail.com, geoPoint lat: 41.14961, lon: -8.61099, hasResults: False
protocolSection identificationModule nctId: NCT06331182, orgStudyIdInfo id: 36264PR552/2/24, briefTitle: Dexmedetomidine and Ketamine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy Pain, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-26, primaryCompletionDateStruct date: 2024-08-01, completionDateStruct date: 2024-08-01, studyFirstPostDateStruct date: 2024-03-26, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: Tanta University, class: OTHER, descriptionModule briefSummary: The aim of this study is to compare the role of dexmedetomidine and ketamine as an adjuvant in external oblique intercostal plane block for post thoracotomy pain., conditionsModule conditions: Dexmedetomidine, conditions: Ketamine, conditions: External Oblique Intercostal Plane Block, conditions: Post Thoracotomy Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Ketamine, interventions name: Dexmedetomidine, interventions name: Bupivacaine, outcomesModule primaryOutcomes measure: Time to the 1st rescue analgesia, secondaryOutcomes measure: Intraoperative fentanyl consumption, secondaryOutcomes measure: Total morphine consumption in the 1st 24hr and 48 hr, secondaryOutcomes measure: Degree of pain, secondaryOutcomes measure: Heart rate, secondaryOutcomes measure: Mean arterial blood, secondaryOutcomes measure: The incidence of adverse events, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Tanta University, status: RECRUITING, city: Tanta, state: ElGharbia, zip: 31527, country: Egypt, contacts name: Mohammed S Elsharkawy, MD, role: CONTACT, phone: 00201148207870, email: mselsharkawy@med.tanta.edu.eg, contacts name: Saad A Moharam, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.78847, lon: 31.00192, hasResults: False
protocolSection identificationModule nctId: NCT06331169, orgStudyIdInfo id: ALTER-BC-Ib-01, briefTitle: Anlotinib With Trastuzumab Deruxtecan for Previously Treated HER2-Low Advanced Breast Cancer, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2026-12-31, completionDateStruct date: 2027-06-30, studyFirstPostDateStruct date: 2024-03-26, lastUpdatePostDateStruct date: 2024-03-26, sponsorCollaboratorsModule leadSponsor name: Fudan University, class: OTHER, descriptionModule briefSummary: A Prospective Phase Ib Study of Anlotinib with Trastuzumab Deruxtecan for HER2-Low Unresectable and/or Metastatic Breast Cancer, conditionsModule conditions: Breast Cancer, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NON_RANDOMIZED, interventionModel: SEQUENTIAL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 42, type: ESTIMATED, armsInterventionsModule interventions name: Anlotinib, interventions name: Trastuzumab deruxtecan, outcomesModule primaryOutcomes measure: Determination of the RP2D of anlotinib in combination with trastuzumab deruxtecan, primaryOutcomes measure: Objective Response Rate (ORR), secondaryOutcomes measure: Duration of Response (DCR), secondaryOutcomes measure: Duration of Response (DOR), secondaryOutcomes measure: Progression-free Survival (PFS), secondaryOutcomes measure: Overall Survival (OS), secondaryOutcomes measure: Number of Participants With Adverse Events (AEs), eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Jian Zhang, city: Shanghai, state: Shanghai, zip: 200433, country: China, contacts name: Jian Zhang, MD,PhD, role: CONTACT, phone: +8664175590, phoneExt: 85000, email: syner2000@163.com, geoPoint lat: 31.22222, lon: 121.45806, hasResults: False
protocolSection identificationModule nctId: NCT06331143, orgStudyIdInfo id: 36264PR551/2/24, briefTitle: Analgesic Efficacy of Mid-Transverse Process to Pleura (MTP) Block and Intrathecal Morphine in Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-28, primaryCompletionDateStruct date: 2024-09-01, completionDateStruct date: 2024-09-01, studyFirstPostDateStruct date: 2024-03-26, lastUpdatePostDateStruct date: 2024-03-29, sponsorCollaboratorsModule leadSponsor name: Tanta University, class: OTHER, descriptionModule briefSummary: The aim of this study is to compare the analgesic efficacy of mid-transverse process to pleura (MTP) block and intrathecal morphine in idiopathic scoliosis patients undergoing posterior spinal fusion surgery., conditionsModule conditions: Mid-Transverse Process Block, conditions: Intrathecal Morphine, conditions: Idiopathic Scoliosis, conditions: Posterior Spinal Fusion, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Ultrasound-Guided Mid-Transverse Process to Pleura (MTP) Block, interventions name: Morphine, outcomesModule primaryOutcomes measure: Degree of pain, secondaryOutcomes measure: Heart rate, secondaryOutcomes measure: Mean arterial pressure, secondaryOutcomes measure: Patient satisfaction, secondaryOutcomes measure: Complications, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Tanta University, status: RECRUITING, city: Tanta, state: ElGharbia, zip: 31527, country: Egypt, contacts name: Mohammed S Elsharkawy, MD, role: CONTACT, phone: 00201148207870, email: mselsharkawy@med.tanta.edu.eg, contacts name: Saad A Moharam, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 30.78847, lon: 31.00192, hasResults: False
protocolSection identificationModule nctId: NCT06331130, orgStudyIdInfo id: 6363, briefTitle: Mesenteric Infiltration in Ovarian Cancer, acronym: MIO, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-06-30, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-03-26, lastUpdatePostDateStruct date: 2024-03-26, sponsorCollaboratorsModule leadSponsor name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS, class: OTHER, collaborators name: Danube University Krems, collaborators name: Institut du Cancer de Montpellier - Val d'Aurelle, collaborators name: Ente Ospedaliero Cantonale, Ticino, Switzerland, descriptionModule briefSummary: To evaluate if CT features at diagnosis in patients with HGSOC can be used to build an Artificial Intelligence model capable of discerning the pathological involvement of the mesentery, assessing the potential impediments for an optimal debulking surgery and predicting the development of resistance to platinum based chemotherapeutic agents., conditionsModule conditions: Ovary Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 510, type: ESTIMATED, armsInterventionsModule interventions name: Computed Tomography, outcomesModule primaryOutcomes measure: Preoperative Artificial Intelligence assisted CT-based evaluation, secondaryOutcomes measure: Evaluation of the Radiologist Assessment of the CT, secondaryOutcomes measure: Prediction of Platinum Resistance, secondaryOutcomes measure: Prediction of Progression Free Survival (PFS) and Overall Survival (OS), eligibilityModule sex: FEMALE, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Advanced Radiology Center, status: RECRUITING, city: Roma, zip: 00168, country: Italy, contacts name: Camilla Panico, MD, role: CONTACT, phone: +390630158637, email: camilla.panico@policlinicogemelli.it, geoPoint lat: 41.89193, lon: 12.51133, hasResults: False
protocolSection identificationModule nctId: NCT06331117, orgStudyIdInfo id: 3776, briefTitle: Effect of RAS/MAPK Pathway Hyperactivation on Growth' and Bone' Profile of the RASopathies, acronym: 3776, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-04-22, primaryCompletionDateStruct date: 2021-12-22, completionDateStruct date: 2026-04-22, studyFirstPostDateStruct date: 2024-03-26, lastUpdatePostDateStruct date: 2024-03-26, sponsorCollaboratorsModule leadSponsor name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS, class: OTHER, descriptionModule briefSummary: Costello syndrome (CS) and cardio-facio cutaneous syndrome (CFCS) belongs to RASopathies, a group of multisystemic disorders caused by unregulated signalling through the RAS/MAPK pathway, an intracellular signalling pathway regulating multiple processes such as cellular proliferation, differentiation, survival, apoptosis and also contributing to oncogenesis. They share a recognizable facial appearance, aged appearance, growth delay, muscle-skeletal anomalies, heart defects, neuropsychological features, skin and ocular abnormalities, and cancer predisposition.Even though life expectancy of individuals with CS and CFCS has increased in the last years due to the improvement of patients' care and a more effective prevention of comorbidities, some of the most challenging aspects impacting on everyday living such as growth failure, accelerate senescence and skeletal-muscle defects, still need to be fully understood. This statement underlies the need to improve clinical research protocols with more innovative techniques (multi-omics profiling) in order to better understand the effect of RAS/MAPK pathway hyperactivations on different systems and to define possible personalized treatments., conditionsModule conditions: RASopathy, conditions: Costello Syndrome, conditions: Noonan Syndrome, conditions: Cardio-Facio-Cutaneous Syndrome, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 120, type: ESTIMATED, armsInterventionsModule interventions name: Diagnostic test, outcomesModule primaryOutcomes measure: Metabolomic profile of the RASopathies, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Department of Woman and Child Health and Public Health, Fondazione Policlinico A. Gemelli, IRCCS, status: RECRUITING, city: Roma, zip: 00168, country: Italy, contacts name: Chiara Leoni, MD, PhD, role: CONTACT, phone: 0039063381344, email: chiara.leoni@policlinicogemelli.it, geoPoint lat: 41.89193, lon: 12.51133, hasResults: False
protocolSection identificationModule nctId: NCT06331104, orgStudyIdInfo id: ChangyeZou, briefTitle: Network Pharmacology Prediction: Mechanism Study of Puerarin in the Treatment of Giant Cell Tumors of Bone, statusModule overallStatus: COMPLETED, startDateStruct date: 2012-06-14, primaryCompletionDateStruct date: 2023-08-31, completionDateStruct date: 2023-08-31, studyFirstPostDateStruct date: 2024-03-26, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Changye Zou, class: OTHER, descriptionModule briefSummary: Based on network pharmacology analysis, this study aims to explore the potential therapeutic targets and molecular mechanisms of puerarin on giant cell tumor of bone (GCTB) genes., conditionsModule conditions: Giant Cell Tumors, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 145, type: ACTUAL, armsInterventionsModule interventions name: gene expression levels, outcomesModule primaryOutcomes measure: P27 expression levels, primaryOutcomes measure: ESR1 expression levels, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Churong Yan, city: Guangzhou, state: Guangdong, zip: 518010, country: China, geoPoint lat: 23.11667, lon: 113.25, hasResults: False
protocolSection identificationModule nctId: NCT06331091, orgStudyIdInfo id: YuzuncuYıl2022/2, briefTitle: Physiotherapy and Reaction Time in Hemophilia, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-12-10, primaryCompletionDateStruct date: 2024-01-19, completionDateStruct date: 2024-01-19, studyFirstPostDateStruct date: 2024-03-26, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Yuzuncu Yıl University, class: OTHER, descriptionModule briefSummary: This randomised controlled study was conducted to investigate the comprehensive physiotherapy combined with home exercises on individuals with hemophilic arthropathy in the lower extremity. There are two groups in the study: home exercises and comprehensive physiotherapy combined with home exercises. Is physiotherapy combined with home exercises superior to home exercises on joint health, bleeding frequency, reaction time, dynamic balance, muscle strength? The aim of this study is to increase the compliance of hemophilic individuals to physiotherapy and adapt home exercises to their lives with weekly sessions., conditionsModule conditions: Hemophilia Arthropathy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomised controlled study, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 21, type: ACTUAL, armsInterventionsModule interventions name: Home exercise, interventions name: Manual therapy, interventions name: Neuromuscular electrical stimulation, interventions name: Supervised exercise, outcomesModule primaryOutcomes measure: Hemophilia Joint Health Score, primaryOutcomes measure: Reaction time, eligibilityModule sex: MALE, minimumAge: 10 Years, maximumAge: 32 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Van Yüzüncü Yıl University, city: Van, zip: 65080, country: Turkey, geoPoint lat: 38.49457, lon: 43.38323, hasResults: False
protocolSection identificationModule nctId: NCT06331078, orgStudyIdInfo id: 29.02.2024/45, briefTitle: Square Step Exercises in Healthy Young Adults, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-08-01, primaryCompletionDateStruct date: 2025-02-01, completionDateStruct date: 2025-08-01, studyFirstPostDateStruct date: 2024-03-26, lastUpdatePostDateStruct date: 2024-03-29, sponsorCollaboratorsModule leadSponsor name: Fenerbahce University, class: OTHER, descriptionModule briefSummary: This study aims to compare the effectiveness of Square Stepping Exercise and aerobic exercise on cognitive function and physical fitness in young adults. Participants aged 18-30 with low physical activity levels will be randomly assigned to either the Square Stepping Exercise Group or Aerobic Exercise Group. Both interventions will be supervised by a physiotherapist, performed twice a week for 40 minutes over 4 weeks. Cognitive function will be assessed using various tests, including attention, short-term memory, and executive function evaluations. Physical fitness will be evaluated through jump tests and balance assessments. Blinded assessors will conduct evaluations at baseline and post-intervention in both groups to determine the impact of square stepping exercise and aerobic exercise on cognitive and physical health in young adults., conditionsModule conditions: Exercise, conditions: Square Step Exercises, conditions: Aerobic Exercise, conditions: Cognitive Function, conditions: Physical Fitness, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Square Stepping Exercise training, interventions name: Aerobic Exercise Training, outcomesModule primaryOutcomes measure: Schulte Grid Test, primaryOutcomes measure: Stroop Test, primaryOutcomes measure: Verbal Fluency Test, primaryOutcomes measure: Digit Span Test, primaryOutcomes measure: Vertical jump test, primaryOutcomes measure: Horizontal jump test, primaryOutcomes measure: Y Balance Test, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 30 Years, stdAges: ADULT, contactsLocationsModule locations facility: Marmara University, city: Maltepe, country: Turkey, geoPoint lat: 40.93567, lon: 29.15507, hasResults: False