hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06260618, orgStudyIdInfo id: 2021/HRE00065, briefTitle: Effect of Chitodex Gel in Tympanoplasty Surgery, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-11-20, primaryCompletionDateStruct date: 2024-05-13, completionDateStruct date: 2024-05-13, studyFirstPostDateStruct date: 2024-02-15, lastUpdatePostDateStruct date: 2024-02-20, sponsorCollaboratorsModule leadSponsor name: Central Adelaide Local Health Network Incorporated, class: OTHER_GOV, collaborators name: University of Adelaide, descriptionModule briefSummary: The general purpose of this study is to compare Chitosan-dextran (Chitodex) gel versus current standard of care, Gelfoam, as a middle ear (ME) and external auditory canal (EAC) packing agent as part of tympanoplasty procedures to close tympanic membrane perforations (TMP)., conditionsModule conditions: Tympanic Membrane Perforation, conditions: Tympanic Membrane Inflammation, conditions: Surgery, conditions: Otitis Media, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Single blinded randomised clinical trial, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: Masked: The people receiving the treatment/s, The people analysing the results/data Unmasked: The surgeon administering the treatment., whoMasked: PARTICIPANT, enrollmentInfo count: 44, type: ESTIMATED, armsInterventionsModule interventions name: Gelfoam, interventions name: Chitodex, outcomesModule primaryOutcomes measure: Number of participants with tympanic membrane closure, primaryOutcomes measure: rate of tympanic membrane closure, secondaryOutcomes measure: Number of participants with improved hearing, secondaryOutcomes measure: Number of participants with improved eardrum function, secondaryOutcomes measure: Ease of use of product compared to active comparator - surgeon feedback, secondaryOutcomes measure: Time taken to complete surgery, secondaryOutcomes measure: Number of Participants with improved quality of life, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The Queen Elizabeth Hospital, status: RECRUITING, city: Adelaide, state: South Australia, zip: 5011, country: Australia, contacts name: Prof Peter John Wormald, MD, role: CONTACT, phone: +61 8 8222 7158, email: pjwormald@gmail.com, contacts name: Emma Barry, BSc (Hons), role: CONTACT, phone: +61 8 8222 7158, email: emma.barry@adelaide.edu.au, contacts name: Prof Peter John Wormald, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -34.92866, lon: 138.59863, locations facility: The Memorial Hospital, status: RECRUITING, city: North Adelaide, state: South Australia, zip: 5006, country: Australia, contacts name: Prof Peter John Wormald, MD, role: CONTACT, phone: +61 8 8222 7158, email: prwormald@gmail.com, geoPoint lat: -34.90733, lon: 138.59141, hasResults: False
protocolSection identificationModule nctId: NCT06260605, orgStudyIdInfo id: Burcu Bayrak 1, secondaryIdInfos id: Burcu, type: REGISTRY, domain: Bayrak, briefTitle: Complications of Diabetes With Puzzles, acronym: Diabetes with, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-12-19, primaryCompletionDateStruct date: 2024-02-20, completionDateStruct date: 2024-03-04, studyFirstPostDateStruct date: 2024-02-15, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Bilecik Seyh Edebali Universitesi, class: OTHER, descriptionModule briefSummary: In this study, it was aimed to investigate the effect of diabetes complications training on endocrine system diseases and nursing care in the Internal Medicine Nursing course on the knowledge level of nursing students., conditionsModule conditions: Diabetes Complications, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 110, type: ACTUAL, armsInterventionsModule interventions name: Education, outcomesModule primaryOutcomes measure: Education, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Bilecik Şeyh Edebali University, city: Bilecik, state: Merkez, country: Turkey, geoPoint lat: 40.14192, lon: 29.97932, hasResults: False
protocolSection identificationModule nctId: NCT06260592, orgStudyIdInfo id: Aysun Acun 4, briefTitle: Ethical Attitude and Humanistic Acting Skills of Intensive Care Nurses, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-06, primaryCompletionDateStruct date: 2024-03, completionDateStruct date: 2024-03, studyFirstPostDateStruct date: 2024-02-15, lastUpdatePostDateStruct date: 2024-02-15, sponsorCollaboratorsModule leadSponsor name: Bilecik Seyh Edebali Universitesi, class: OTHER, descriptionModule briefSummary: Today, rapidly developing technology and changing treatment and care conditions increase the tendency towards ethical values both as an intellectual concept and as a moral guide. The nursing profession, which focuses on people in ethical terms, is also performed by people. This situation brings with it many ethical dilemmas in areas where health care services are provided. In ICUs, long and critical treatments of patients, differences of opinion between the medical team and the institution, non-compliance with patient rights, difficulties in terminal patient care, procedures performed without the patient\&#39;s consent, distribution of limited medical resources, unethical attitudes and attitudes of nurse colleagues, Many issues such as long-term exposure to stressors and constant alarm sounds can cause mental distress and negative emotions in intensive care nurses. One of the effective ways to increase the quality of care provided by nurses is humanistic practice ability. The presence of humanistic practice ability provides more realistic, human-centered nursing care, improves the quality of life of patients, and also positively affects health expenditures., conditionsModule conditions: Humanistic Care Skills, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 400, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Ethical compliance of nurses in the intensive care unit, secondaryOutcomes measure: Humanistic care skills of nurses in the intensive care unit, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Bilecik Şeyh Edebali University, status: RECRUITING, city: Bilecik, zip: 11000, country: Turkey, contacts name: Aysun Acun, PhD, role: CONTACT, phone: +905072104506, email: aysun.acun@bilecik.edu.tr, contacts name: Aysun Acun, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.14192, lon: 29.97932, hasResults: False
protocolSection identificationModule nctId: NCT06260566, orgStudyIdInfo id: H-52570, briefTitle: Tolerability of Enteral NAC in Infants, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2027-02, completionDateStruct date: 2027-02, studyFirstPostDateStruct date: 2024-02-15, lastUpdatePostDateStruct date: 2024-04-15, sponsorCollaboratorsModule leadSponsor name: Sanjiv Harpavat, class: OTHER, collaborators name: Baylor College of Medicine, descriptionModule briefSummary: Biliary atresia (BA) is a neonatal liver disease characterized by impaired bile flow and is the most common indication for pediatric liver transplantation. BA can be treated with the Kasai portoenterostomy (KP), a procedure that attempts to restore bile flow and slow disease progression. However, success of the KP procedure is quite variable, and lack of adjuvant medical therapies following KP is a major gap in pediatric hepatology.This study begins to explore oral N-acetylcysteine (NAC) as a potential medical therapy in BA by determining whether an oral formulation can be given to infants. The primary objective is to determine tolerability of the oral NAC formulation. The primary outcome is tolerating at least 3 out of 4 total doses without emesis. The Bayesian Optimal Interval Design (BOIN) trial design will be used to determine the maximum tolerated dose of oral NAC. Our secondary objective is to assess palatability of the oral NAC formulation by comparing facial expressions when taking oral NAC versus other medications commonly given to cholestatic infants., conditionsModule conditions: Biliary Atresia, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: The study consists of two parts:* Administering applesauce alone (lead-in): In study days 1-2, infants will receive one infant spoon (approximately ½ teaspoon) of plain applesauce by mouth twice a day. If the infant tolerates 3-4 of 4 total doses without emesis, the infant will progress to the final two days of the study.* Administering applesauce plus NAC (for infants who tolerate applesauce in study days 1-2): In study days 3-4, infants will receive an individualized dose of powdered oral NAC mixed into one infant spoon of applesauce by mouth twice a day for a maximum of four doses of NAC medication., primaryPurpose: OTHER, maskingInfo masking: NONE, maskingDescription: N/A. No Masking, enrollmentInfo count: 12, type: ESTIMATED, armsInterventionsModule interventions name: N-Acetylcysteine, outcomesModule primaryOutcomes measure: No emesis within 30 minutes of administration of at least 3 of 4 total doses of oral NAC, secondaryOutcomes measure: Oral NAC palatability compared to clinically indicated medications using the facial expression scale, secondaryOutcomes measure: Oral NAC-specific adverse event evaluation, eligibilityModule sex: ALL, minimumAge: 122 Days, maximumAge: 273 Days, stdAges: CHILD, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06260553, orgStudyIdInfo id: SCOG008, briefTitle: Metronomic Oral Vinorelbine Combination With Tislelizumab in EGFR/ALK-negative Advanced NSCLC, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2024-02-07, primaryCompletionDateStruct date: 2025-02-07, completionDateStruct date: 2025-08-07, studyFirstPostDateStruct date: 2024-02-15, lastUpdatePostDateStruct date: 2024-02-15, sponsorCollaboratorsModule leadSponsor name: Fujian Cancer Hospital, class: OTHER_GOV, descriptionModule briefSummary: To evaluate the efficacy of metronomic chemotherapy combination with tislelizumab in EGFR/ALK-negative advanced NSCLC patients intolerant to first-line standard chemotherapy., conditionsModule conditions: EGFR/ ALK-negative Advanced NSCLC, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: tislelizumab and metronomic oral vinorelbine, outcomesModule primaryOutcomes measure: PFS, secondaryOutcomes measure: ORR, secondaryOutcomes measure: DCR, secondaryOutcomes measure: AE, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Fujian cancer hospital, city: Fuzhou, state: Fujian, country: China, geoPoint lat: 26.06139, lon: 119.30611, hasResults: False
protocolSection identificationModule nctId: NCT06260540, orgStudyIdInfo id: Core Endurance, briefTitle: Core Endurance in Healthy Young Adults, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-01, primaryCompletionDateStruct date: 2024-02-29, completionDateStruct date: 2024-04-29, studyFirstPostDateStruct date: 2024-02-15, lastUpdatePostDateStruct date: 2024-03-26, sponsorCollaboratorsModule leadSponsor name: Karabuk University, class: OTHER, descriptionModule briefSummary: This study aimed to examine the effect of core endurance levels on upper extremity function, muscle strength and reaction time in healthy young adults. The "core" region functions as a connection point between the upper and lower extremities and enables the transfer of force from this region to the extremities. This region is a basic structure where the force required for all movements is generated and transmitted from the proximal segments to the distal segments. "Core" stabilization has a significant impact on limb functionality, and stabilization of the proximal segments is necessary to maintain the mobility and function of the distal segments. To establish a stable base during functional activities, the "core" muscles are activated before the upper and lower extremity muscles. This ensures force production and transfer of resulting forces, thus supporting the mobility of the distal segments. Increasing core stabilization increases force production in the extremities, and control of core strength, balance and movement maximizes upper and lower extremity functions. Any impairment in core stabilization reduces the quality of movement and increases the risk of injury to the upper extremity. Therefore, it has been stated that "core" stabilization has a significant effect on athletic performance and upper extremity functions. There are not enough studies in the literature investigating this effect in healthy young adults. Most existing studies focus on the role of core endurance on athlete performance.The aim of this study is not only to investigate core endurance levels in healthy young adults but also to examine the effect of core endurance levels on upper extremity function, muscle strength and reaction time., conditionsModule conditions: Health Risk Behaviors, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 104, type: ESTIMATED, outcomesModule primaryOutcomes measure: Side bridge test, primaryOutcomes measure: Prone bridge test (plank) test, primaryOutcomes measure: Trunk flexion endurance test, primaryOutcomes measure: Sorensen test, secondaryOutcomes measure: Purdue Pegboard test, secondaryOutcomes measure: Isometric hand dynamometer for muscle strength, secondaryOutcomes measure: Nelson hand reaction test, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 25 Years, stdAges: ADULT, contactsLocationsModule locations facility: Karabuk University, status: RECRUITING, city: Karabuk, zip: 78000, country: Turkey, geoPoint lat: 41.20488, lon: 32.62768, hasResults: False
protocolSection identificationModule nctId: NCT06260514, orgStudyIdInfo id: APR-1051-001, briefTitle: Study of APR-1051 in Patients With Advanced Solid Tumors, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06, primaryCompletionDateStruct date: 2027-06, completionDateStruct date: 2028-06, studyFirstPostDateStruct date: 2024-02-15, lastUpdatePostDateStruct date: 2024-02-15, sponsorCollaboratorsModule leadSponsor name: Aprea Therapeutics, class: INDUSTRY, descriptionModule briefSummary: The purpose of this study is to assess the safety and effectiveness of APR-1051 through the performance of a Phase 1, open-label, safety, PK, and preliminary efficacy study of oral APR-1051 in patients with advanced solid tumors., conditionsModule conditions: Advanced Solid Tumor, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 79, type: ESTIMATED, armsInterventionsModule interventions name: APR-1051, outcomesModule primaryOutcomes measure: Treatment-related adverse events, primaryOutcomes measure: Recommended dose of APR-1051, secondaryOutcomes measure: Pharmacokinetics: Cmax/Cmin of APR-1051, secondaryOutcomes measure: Pharmacokinetics: Tmax of APR-1051, secondaryOutcomes measure: Pharmacokinetics: AUC of APR-1051, secondaryOutcomes measure: Pharmacokinetics: t1/2 of APR-1051, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06260501, orgStudyIdInfo id: ATADEK-2023-13/463, briefTitle: Wetting Solution-ideal Body Weight Ratio in Liposuction Procedures, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-09-01, primaryCompletionDateStruct date: 2023-09-30, completionDateStruct date: 2023-10-30, studyFirstPostDateStruct date: 2024-02-15, lastUpdatePostDateStruct date: 2024-02-15, sponsorCollaboratorsModule leadSponsor name: Acibadem University, class: OTHER, descriptionModule briefSummary: Although the use of wetting solutions during high-volume liposuction is a standard approach, it is unclear how to optimize wetting solutions and components and their effect on postoperative complications.. Since the super-wet technique (aspiration of 1 cc per 1 cc of infiltrate) was introduced in 1986, it has become one of the most frequently applied techniques worldwide . Adrenaline and lidocaine are often added to WS due to their hemostatic and analgesic effects One of the major advantages of super-wet technique is that blood loss is quite low. However, potential cardiovascular side effects of WS and the amounts of epinephrine and lidocaine they contain, such as volume overload, local anesthetic toxicity, hypertension, arrhythmia, and tachycardia, are still a scoop of investigation. In this study, we examined the WS and the medications it contains from a different perspective to understand the possible cause of these adverse outcomes. Despite the most suitable candidates for liposuction are patients with a BMI\<30 kg/m2 and low comorbidity and age, the patient group undergoing liposuction is often obese, and overweight individuals require that obesity-related pathophysiological changes be taken into consideration. Therefore, we analyzed the patients by dividing them into two groups according to the amount of WS applied according to their IBW (WS/IBW≤90ml/kg: group I and WS/IBW\>90ml/kg: group I). In this study we aimed to evaluate the effect of wetting solutions and components calculated according to ideal body weight (IBW) on postoperative complications, conditionsModule conditions: Liposuction, conditions: Obesity, conditions: Postoperative Complications, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: RETROSPECTIVE, enrollmentInfo count: 192, type: ACTUAL, armsInterventionsModule interventions name: super-wet technique, outcomesModule primaryOutcomes measure: Mean arterial pressure (MAP) was measured to detect hypertension and hypotension., primaryOutcomes measure: The Numerical Pain Rating Scale (NRS) was used to assess postoperative pain level, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Acibadem Altunizade Hospital, city: Istanbul, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06260488, orgStudyIdInfo id: 8925, briefTitle: Histological Segmentation of the Superficial Femoral Artery From Microscan to CT Using Artificial Intelligence, acronym: CTPred, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-02-15, primaryCompletionDateStruct date: 2025-06-15, completionDateStruct date: 2025-08-15, studyFirstPostDateStruct date: 2024-02-15, lastUpdatePostDateStruct date: 2024-02-15, sponsorCollaboratorsModule leadSponsor name: University Hospital, Strasbourg, France, class: OTHER, descriptionModule briefSummary: The femoropopliteal artery segment (FPAS) is one of the longest arteries in the human body, undergoing torsion, compression, flexion and extension due to lower limb movements. Endovascular surgery is considered to be the treatment of choice for the peripheral arterial disease, the results of which depend on the physiological forces on the arterial wall, the anatomy of the vessels and the characteristics of the lesions being treated. The atheromatous disease includes, in a simple way, 3 categories of plaques: calcified, fibrous, and lipidic. The study of these plaques and their differentiation in imaging and histology in the FPAS has already been the subject of research. To treat them, there are angioplasty balloons and stents with different designs and components, with different mechanical properties and different impregnated molecules.There is no non-invasive method (imaging) to accurately differentiate lesions along the FPAS. The analysis is performed from the preoperative CT scan, but there are high-resolution scanners that allow a quasi-histological analysis of the tissue.This microscanner can be used ex vivo. In the framework of a project, the learning algorithm was be créated (Convolutional Neural Networks) to automatically segment microscanner slices: after taking FPAS from amputated limbs, we correlated ex-vivo microscanner images of the arteries with their histology. The correlation was then performed manually between the microscanner images, and the histological sections obtained. the algorithm well be trained on these slices and validated its performance. The validation of the CT and microscanner concordance was the subject of scientific publications., conditionsModule conditions: Peripheral Artery Disease, conditions: Femoropopliteal Stenosis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Endovascular surgery, outcomesModule primaryOutcomes measure: Assessing the feasibility of histological segmentation of the superficial femoral artery on preoperative microscanner using artificial intelligence, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False