hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06284850, orgStudyIdInfo id: Christina Trakatelli, briefTitle: Empagliflozin and Red Blood Cell 2,3-biphosphoglycerate Levels, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-30, primaryCompletionDateStruct date: 2025-11, completionDateStruct date: 2025-11, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Aristotle University Of Thessaloniki, class: OTHER, descriptionModule briefSummary: The aim of this study is to investigate the hypothesis that treatment with empagliflozin may have an impact on red blood cell 2,3-biphosphoglycerate levels affecting tissue oxygen supply and thus mediating part of the cardio- and reno- protective effect of SGLT-2 inhibitors., conditionsModule conditions: Hematocrit Change, conditions: Cardiovascular Prevention, conditions: Empagliflozin, conditions: SGLT2-Inhibitors, conditions: Tissue Oxygenation, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Empagliflozin10Mg Tab, outcomesModule primaryOutcomes measure: Mean change in red blood cell 2,3-biphosphoglycerate levels (μmol/ml), secondaryOutcomes measure: Mean change in Hct (%), secondaryOutcomes measure: Hb (mg/dl), secondaryOutcomes measure: RBC (x1000000/μl), secondaryOutcomes measure: MCV (fl),, secondaryOutcomes measure: HbA1c (%, mmol/mol),, secondaryOutcomes measure: erythropoietin (mU/ml), secondaryOutcomes measure: eGFR (ml/min/1.73m2),, secondaryOutcomes measure: Urine Albumin to Creatinine Ratio (mg/g), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Papageorgiou General Hospital, status: RECRUITING, city: Thessaloniki, state: Central Macedonia, zip: 56403, country: Greece, contacts name: KONSTANTINOS KITSIOS, MD,MSc,PhD, role: CONTACT, phone: +306977295744, email: kitsios_k@yahoo.gr, geoPoint lat: 40.64361, lon: 22.93086, hasResults: False
protocolSection identificationModule nctId: NCT06284824, orgStudyIdInfo id: DPS-JMP-2022-040, briefTitle: Comparison of Two Robotic-Assisted Total Knee Arthroplasty Systems, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2026-05, completionDateStruct date: 2027-05, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Southeast Orthopedic Specialists, class: NETWORK, collaborators name: DePuy Orthopaedics, collaborators name: Stryker Orthopaedics, descriptionModule briefSummary: The goal of this prospective study is to compare two different knee replacement robots. This study will look at patient reported outcome measures and data collected during the operation. The main questions this study aims to answer include:* Will the patient reported outcomes differ between the two groups?* Will the intraoperative data differ between the two groups? Participants will undergo total knee replacement with one of the two robots, complete standardized surveys, and have x-rays taken., conditionsModule conditions: Knee Osteoarthritis, conditions: Knee Arthritis, conditions: Knee Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 120, type: ESTIMATED, armsInterventionsModule interventions name: Stryker Triathlon with MAKO Robotic-Arm, interventions name: DePuy Attune with VELYS Robotic-Assistance, outcomesModule primaryOutcomes measure: KSS, primaryOutcomes measure: KSS, primaryOutcomes measure: KSS, primaryOutcomes measure: KSS, primaryOutcomes measure: KOOS JR, primaryOutcomes measure: KOOS JR, primaryOutcomes measure: KOOS JR, primaryOutcomes measure: KOOS JR, primaryOutcomes measure: FJS-12 Knee, primaryOutcomes measure: FJS-12 Knee, primaryOutcomes measure: FJS-12 Knee, secondaryOutcomes measure: Operative step time, otherOutcomes measure: Bone resected, otherOutcomes measure: Costs for surgery, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06284811, orgStudyIdInfo id: 050.06.04/155, briefTitle: Massage and Percussion Therapy on Muscle and Performance Parameters, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-31, primaryCompletionDateStruct date: 2024-04-15, completionDateStruct date: 2024-04-20, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Acibadem University, class: OTHER, collaborators name: Istanbul Aydın University, collaborators name: Biruni University, descriptionModule briefSummary: DOMS, muscle viscoelastic properties, quadriceps strength and vertical jump performance will be evaluated in physically active individuals before the exercise and after the exercise and intervention which is either Swedish massage or Percussion therapy, conditionsModule conditions: Healthy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 24, type: ESTIMATED, armsInterventionsModule interventions name: Exercise program focusing on quadriceps, outcomesModule primaryOutcomes measure: Muscle tone/tension(Hz), primaryOutcomes measure: Muscle dynamic stiffness (N/m), primaryOutcomes measure: Muscle elasticity (log), primaryOutcomes measure: DOMS, primaryOutcomes measure: Vertical Jump Performance, primaryOutcomes measure: Quadriceps isometric strength, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 30 Years, stdAges: ADULT, contactsLocationsModule locations facility: Acibadem University, status: RECRUITING, city: Istanbul, state: Ataşehir, zip: 34752, country: Turkey, contacts name: Özge Haklı, Research Assisstant, role: CONTACT, phone: +902165004221, email: ozge.kocaer@acibadem.edu.tr, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06284785, orgStudyIdInfo id: 2023.0121, briefTitle: The Effects of Bariatric Surgery on Kidney Oxygenation in Obese Adults With Type 2 Diabetes and Hyperfiltration, acronym: ECSTASY, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-08-01, primaryCompletionDateStruct date: 2026-01-01, completionDateStruct date: 2026-03-01, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Amsterdam UMC, location VUmc, class: OTHER, collaborators name: Dutch Kidney Foundation, collaborators name: Dutch Diabetes Research Foundation, descriptionModule briefSummary: In this study the investigators will examine the effects of VAT reduction by bariatric surgery on kidney hypoxia and compare kidney oxygenation before- and after surgery in both sexes using BOLD-MRI and measures of kidney hemodynamic function. Furthermore, the investigators will assess whether kidney oxygenation is reduced in obese T2D men and women versus various controls as described below. This will determine whether kidney hypoxia can be appointed as a modifiable pathogenic factor in early DKD and non-surgical interventions targeting kidney hypoxia can be designed to slow DKD progression., conditionsModule conditions: Kidney Hypoxia, conditions: Diabetes Mellitus, Type 2, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Bariatric surgery, outcomesModule primaryOutcomes measure: Difference in kidney oxygenation before and after bariatric surgery, secondaryOutcomes measure: Difference in kidney oxygenation between men and women, secondaryOutcomes measure: Difference in kidney oxygenation between obese, hyperfiltering men and women with T2D versus non-diabetic lean controls, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: VU University Medical Center, status: RECRUITING, city: Amsterdam, state: Noord-Holland, zip: 1081HV, country: Netherlands, contacts name: Daniel H van Raalte, MD, role: CONTACT, phone: +31 204442974, email: d.vanraalte@vumc.nl, contacts name: Daniel H van Raalte, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.37403, lon: 4.88969, hasResults: False
protocolSection identificationModule nctId: NCT06284772, orgStudyIdInfo id: 4457/2023, briefTitle: FINRISK 2002 Re-examination, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2023-11-13, primaryCompletionDateStruct date: 2024-06-25, completionDateStruct date: 2024-06-25, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: University of Turku, class: OTHER, collaborators name: Finnish Institute for Health and Welfare, descriptionModule briefSummary: The project aims to fill in the existing gaps in the study of the microbiome as a cardiometabolic driver 1) by determining the key demographic, environmental, genetic, dietary, and metabolic correlates of long-term within-individual microbiome and microbial metabolite changes; and 2) by assessing how the gut microbiome, microbial metabolites, and their long-term changes are prospectively related to the risk factors, surrogate markers, and overt outcomes of CMD. To achieve this goal, repeat stool samples will be collected of \~2300 Finnish individuals who gave stool samples in the year 2002. In addition, \~300 individuals will undergo a in-depth health examination in 2024., conditionsModule conditions: Cardiometabolic Syndrome, conditions: Cardiovascular Diseases, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 2300, type: ESTIMATED, armsInterventionsModule interventions name: Questionnaire and fecal sampling, interventions name: Health examination, outcomesModule primaryOutcomes measure: Gut microbiome change between 2002-2024, secondaryOutcomes measure: Correlates of gut microbiome change between 2002-2024, eligibilityModule sex: ALL, minimumAge: 47 Years, maximumAge: 96 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Turku, city: Turku, zip: 20100, country: Finland, geoPoint lat: 60.45148, lon: 22.26869, hasResults: False
protocolSection identificationModule nctId: NCT06284759, orgStudyIdInfo id: E-77082166-302.08.01-380534, briefTitle: The Effect of Tele-Nursing Application on Self-Care Ability and Daily Living Activities in Fracture Surgery Patients, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2023-09-15, primaryCompletionDateStruct date: 2024-03-28, completionDateStruct date: 2024-03-28, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Gazi University, class: OTHER, collaborators name: Lokman Hekim Üniversitesi, collaborators name: Ankara City Hospital Bilkent, descriptionModule briefSummary: This study aims to determine the effect of tele-nursing application based on Orem's Self-care Theory on self-care agency and daily living activities in trauma-related lower extremity fracture surgery patients., conditionsModule conditions: Lower Extremity Fracture, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, maskingDescription: In the study, the statistician was blinded using the blind technique., whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 52, type: ACTUAL, armsInterventionsModule interventions name: post-discharge telenursing intervention, outcomesModule primaryOutcomes measure: Self Care, Assessed using the Self-Care Agency scale., primaryOutcomes measure: Activities of daily living, Assessed using the Katz index of independence in activities of daily living (ADL) scale., primaryOutcomes measure: Instrumental activities of daily living, Assessed using the The Lawton instrumental activities of daily living scale., eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Lokman Hekim University, city: Ankara, zip: 06510, country: Turkey, geoPoint lat: 39.91987, lon: 32.85427, hasResults: False
protocolSection identificationModule nctId: NCT06284746, orgStudyIdInfo id: 301Qiaoz, briefTitle: Tirelizumab Combined With Chemotherapy in the Treatment of HER-2 Negative Locally Advanced Gastric Cancer, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-10-01, primaryCompletionDateStruct date: 2025-04-30, completionDateStruct date: 2025-07-30, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Lin Chen, class: OTHER, descriptionModule briefSummary: This study objectively analyzes the safety and survival evaluation of perioperative immunotherapy combined with chemotherapy in locally advanced gastric cancer patients through a prospective randomized controlled trial research method; By comparing the pathological response rate, disease-free survival rate, and incidence of adverse events between the combination therapy and chemotherapy alone group, we aim to verify the efficacy and safety of tirelizumab combined with SOX/XELOX chemotherapy in disease control of locally advanced gastric cancer patients, laying the foundation and providing a basis for large-scale multicenter clinical research., conditionsModule conditions: Locally Advanced Gastric Carcinoma, conditions: HER2 Negative, conditions: Efficacy, conditions: Safety, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Tirolizumab+SOX/XELOX, interventions name: SOX/XELOX, outcomesModule primaryOutcomes measure: Pathological complete response (pCR), primaryOutcomes measure: Objective Response Rate（ORR）, secondaryOutcomes measure: Disease-free survival（DFS）, secondaryOutcomes measure: Overall survival（OS）, secondaryOutcomes measure: Major Pathologic Response（MPR）, secondaryOutcomes measure: The incidence of adverse events during treatment, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: General Surgery Institute, China PLA General Hospital, status: RECRUITING, city: Beijing, state: Beijing, zip: 100853, country: China, contacts name: Yunhe Gao, Ph.D., role: CONTACT, phone: 86-010-66937164, email: gaoyunhe@301hospital.org, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False
protocolSection identificationModule nctId: NCT06284733, orgStudyIdInfo id: P.T.REC/012/004874, briefTitle: Whole-body Vibration Without Visual Feedback on Postural Steadiness in Unilateral Trans-femoral Traumatic Amputees, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-11-05, primaryCompletionDateStruct date: 2024-04-08, completionDateStruct date: 2024-04-20, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: MTI University, class: OTHER, descriptionModule briefSummary: This study will investigate the effects of Whole-body vibration without visual feedback on postural steadiness in unilateral trans-femoral traumatic amputees. This study will be carried out at the outpatient clinic of the faculty of physical therapy, modern university for technology and information, and El Wafaa wel Amal hospital.All participants will sign a written consent form after receiving full information about the purpose of the study, procedure, possible benefits, privacy, and use of data., conditionsModule conditions: Amputation; Traumatic, Leg, Lower, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: They will be assigned into three equal groups:, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: Double blinded, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 115, type: ACTUAL, armsInterventionsModule interventions name: Whole-body vibration plus conservative care, interventions name: conservative care, outcomesModule primaryOutcomes measure: Prosthetic leg stability test, secondaryOutcomes measure: Sway Index, secondaryOutcomes measure: Limits of Stability Test, eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: Ahmed Mohamed Ahmed Abdelhady, city: Cairo, country: Egypt, geoPoint lat: 30.06263, lon: 31.24967, hasResults: False
protocolSection identificationModule nctId: NCT06284707, orgStudyIdInfo id: Rhythmic_PAU_2024, briefTitle: Effect of Rhythmic Gymnastics Training in Children With Down Syndrome, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2024-03-08, completionDateStruct date: 2024-05-05, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: University of Castilla-La Mancha, class: OTHER, descriptionModule briefSummary: Some of the clinical characteristics of people with Down syndrome (DS) are orthopedic, cardiovascular, neuromuscular, visual, cognitive and perceptual disorders, which directly affect the quality of their movements. Children with DS often have a sedentary lifestyle or low levels of physical activity which exacerbates problems related to obesity and overall physical health. Therefore, the practice of physical exercise in this type of population is essential to improve their health-related physical fitness. The aim of this study was to analyze the influence of an adapted rhythmic gymnastics training program on body composition, tendon architecture and stiffness, and physical capacity in children with DS., conditionsModule conditions: Physical Conditioning, Human, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: OTHER, maskingInfo masking: TRIPLE, maskingDescription: The care provider will be responsible for administering the training program. Two different people will develop swimming training and rhythmic gymnastics training. Each participant will be assigned a code. The researcher will process the data with the code of each participant., whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: swimming training, interventions name: rhythmic gymnastics training, outcomesModule primaryOutcomes measure: Body composition, primaryOutcomes measure: Tendon thickness, primaryOutcomes measure: Stiffness tendon, primaryOutcomes measure: Hamstrings flexibility, primaryOutcomes measure: body mass index, primaryOutcomes measure: visceral fat area, primaryOutcomes measure: metabolism, primaryOutcomes measure: tendon elastography, primaryOutcomes measure: balance, primaryOutcomes measure: functional capacity, eligibilityModule sex: ALL, minimumAge: 6 Years, maximumAge: 20 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Universidad de Castilla La Mancha, status: RECRUITING, city: Toledo, zip: 45071, country: Spain, contacts name: Paula Esteban-García, PhD, role: CONTACT, phone: 925 26 88 00, email: paula.esteban@uclm.es, geoPoint lat: 39.8581, lon: -4.02263, hasResults: False
protocolSection identificationModule nctId: NCT06284694, orgStudyIdInfo id: REB23-0120, briefTitle: Treatment of Neuropathic Pain Following Spinal Cord Injury - a rTMS Approach, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-06-30, completionDateStruct date: 2025-06-30, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: University of Calgary, class: OTHER, descriptionModule briefSummary: This study aims to determine if repetitive transcranial magnetic stimulation (rTMS) can improve pain symptomology in adults with neuropathic pain (NP) following a spinal cord injury (SCI)., conditionsModule conditions: Neuropathic Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: All participants will receive active rTMS treatment., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: Repetitive Transcranial Magnetic Stimulation (rTMS), outcomesModule primaryOutcomes measure: International Spinal Cord Injury Pain Basic Data Set (ISCIPBDS) v3.0, primaryOutcomes measure: Patient-Reported Outcomes Measurement Information System (PROMIS) Scale Neuropathic Pain Quality 5a, secondaryOutcomes measure: Quality of Life Index Spinal Cord Injury version (QLI-SCI), secondaryOutcomes measure: Pain Catastrophizing Scale (PCS), secondaryOutcomes measure: World Health Organization Disability Assessment Schedule (WHODAS) 2.0, secondaryOutcomes measure: Generalized Anxiety Disorder scale-7 (GAD-7), secondaryOutcomes measure: Patient Health Questionnaire-9 (PHQ-9), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Foothills Medical Centre, city: Calgary, state: Alberta, zip: T2N 2T9, country: Canada, geoPoint lat: 51.05011, lon: -114.08529, hasResults: False