protocolSection identificationModule nctId: NCT06319781, orgStudyIdInfo id: H-23038433, briefTitle: A Pilot Cohort Study of Risk Factors and Novel Methods of Skin Lesion Assessments in Adults With Atopic Dermatitis, Alopecia Areata, Psoriasis or Vitiligo, acronym: Derma-001, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-15, primaryCompletionDateStruct date: 2025-05, completionDateStruct date: 2025-05, studyFirstPostDateStruct date: 2024-03-20, lastUpdatePostDateStruct date: 2024-03-20, sponsorCollaboratorsModule leadSponsor name: Blueskin AS, class: INDUSTRY, descriptionModule briefSummary: The objective of the study is to explore various clinical and biochemical parameters and their potential associations with disease severity, activity, and prognosis in atopic dermatitis, psoriasis, alopecia areata, and vitiligo. Further, the study aims at validating remote assessments of skin lesions, using smartphone-acquired photos. The study will also assess the feasibility and compliance with weekly remote-assessments and patient-reported data collection over the full study period of one year. The study will observe patients through a period of one year and will provide detailed information concerning the type and dose of medication used, as well as data to evaluate the disease activity with high resolution during this period. The study will involve collection of serum samples for exploratory biomarkers, and punch biopsies. A total of approximately 370 patients, divided into the four disease areas of atopic dermatitis, alopecia areata, psoriasis, and vitiligo, will be enrolled in the study. Using a combination of self-reported and on-site assessments and procedures, the intent is to observe the natural history of patients with select dermatological conditions, investigate tissue characteristics associated with disease activity and symptoms, and evaluate the validity of remote assessment of lesions, and feasibility of weekly self-acquired smart-phone images of skin lesions for remote assessment., conditionsModule conditions: Alopecia Areata, conditions: Vitiligo, conditions: Atopic Dermatitis, conditions: Psoriasis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 370, type: ESTIMATED, armsInterventionsModule interventions name: Observational, outcomesModule primaryOutcomes measure: Severity of the disease., primaryOutcomes measure: Clinical characteristics and disease activity., primaryOutcomes measure: Tissue profiling and disease activity., primaryOutcomes measure: Disease activity and biomarkers., primaryOutcomes measure: Quality of life., primaryOutcomes measure: Compliance of remote tasks., primaryOutcomes measure: Quality of smartphone collected photos., primaryOutcomes measure: Level of agreement between the in-person and remote scoring, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Sanos Clinic, Gandrup, status: RECRUITING, city: Gandrup, zip: 9362, country: Denmark, contacts name: Cecilie Rovsing, MD, role: CONTACT, phone: +45 7370 8220, email: info.nordjylland@sanosclinic.com, geoPoint lat: 56.74249, lon: 9.82298, locations facility: Sanos Clinic, Herlev, status: RECRUITING, city: Herlev, zip: 2730, country: Denmark, contacts name: Zarqa Ali, PhD, role: CONTACT, phone: +45 7370 8200, email: info@sanosclinic.com, geoPoint lat: 55.72366, lon: 12.43998, locations facility: Sanos Clinic, Vejle, status: RECRUITING, city: Vejle, zip: 7100, country: Denmark, contacts name: Randi Kviesgaard Bechmann, MD, role: CONTACT, phone: +45 7370 8210, email: info.syddanmark@sanosclinic.com, geoPoint lat: 55.70927, lon: 9.5357, hasResults: False