protocolSection identificationModule nctId: NCT06287983, orgStudyIdInfo id: KayseriCHIMT001, briefTitle: Effect of Inspiratory Muscle Training on Respiratory Functions and Exercise Capacity, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-06-01, primaryCompletionDateStruct date: 2024-03-31, completionDateStruct date: 2024-05-15, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Kayseri City Hospital, class: OTHER_GOV, descriptionModule briefSummary: In this study, we aimed to evaluate the effect of Anti- tumor necrosis factor (TNF) treatment on pulmonary functions in patients with AS and to evaluate the pulmonary functions and exercise performance of patients by adding inspiratory muscle training to spinal mobility exercises in patients with AS using Anti-TNF. We also aimed to investigate the relationship between these parameters and disease activity, spinal mobility and quality of life., conditionsModule conditions: Ankylosing Spondylitis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: SEQUENTIAL, interventionModelDescription: A total of 44 patients were randomly divided into 2 groups using the sealed envelope randomization method. The exercise program will be applied to both groups 3 sessions a week for 60 minutes for 6 weeks. Inspiratory muscle training will also be added to the intervention group. Patients included in the study; At weeks 0, 6, 12 and 24, BASDAI (Bath Ankylosing Spondylitis Disease Activity Index), BASFI (Bath Ankylosing Spondylitis Functional Index), ASQoL (The Ankylosing Spondylitis Quality of Life), Modified Borg Scale, Visual Analog scale (VAS) and maximum Dyspnea measurement during exercise, 6-minute walk test, chest expansion measurement and respiratory function test (spirometry) will be evaluated., primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 44, type: ESTIMATED, armsInterventionsModule interventions name: Inspiratory Muscle Trainer (IMT) (POWERbreathe Medic Classic), interventions name: The Sample Spondylitis Exercise Program, outcomesModule primaryOutcomes measure: Respiratory function test (Spirometry), secondaryOutcomes measure: Bath Ankylosing Spondylitis Disease Activity Index (BASDAI):, secondaryOutcomes measure: Bath Ankylosing Spondylitis Functional Index (BASFI), secondaryOutcomes measure: Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL), secondaryOutcomes measure: Modified Borg Scale, secondaryOutcomes measure: Measurement of dyspnea at maximum exercise with the Visual Analog Scale (VAS), secondaryOutcomes measure: 6-minute walk test (6MWT), secondaryOutcomes measure: Chest expansion measurement, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Health Sciences University, Kayseri Medicine Faculty, Kayseri City Hospital, status: RECRUITING, city: Kayseri, zip: 38080, country: Turkey, contacts name: Havva Talay Çalış, Prof, role: CONTACT, phone: +90352 315 77 00, phoneExt: 61244, email: htalaycalis@yahoo.com, contacts name: Esra Yaprak Tas, MD, role: CONTACT, phone: +905062007571, email: yaprak8100@gmail.com, geoPoint lat: 38.73222, lon: 35.48528, hasResults: False