protocolSection identificationModule nctId: NCT06341803, orgStudyIdInfo id: DSRB 2023/00397, briefTitle: Personalized Transcranial Magnetic Stimulation Treatment for Depression, acronym: APIC-TMS, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-04-01, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-04-02, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Institute of Mental Health, Singapore, class: OTHER, collaborators name: National University of Singapore, descriptionModule briefSummary: This proposal seeks to conduct a pragmatic single arm, open label pilot implementation to validate our individualized functional Magnetic Resonance Imaging (fMRI) connectome-guided localization approach for accelerated TMS among Asian patients with depression.Participants will be patients with Major Depressive Disorder not responding to standard treatment, with no exclusions to fMRI or transcranial magnetic stimulation (TMS) (essentially metal implants in the head) and willing to participate in the pilot.All participants will undergo MRI scans before and after the accelerated TMS treatment. The multi-session hierarchical Bayesian model (MS-HBM) approach will be used to estimate individualized connectome-guided target locations.Patients will undergo accelerated TMS applied to individualized connectome-guided target locations (based on the MS-HBM approach).Patients will undergo 10 sessions (each session lasting 10 min) spread out over 10 hours each day for 5 consecutive working days.All clinical outcome data will be collected for each patient by a pre-defined questionnaire at four time points: at baseline, post-treatment, 1 month and 3 months during follow-up.The clinical outcome data will be analyzed using linear regression or repeated analysis of variance (ANOVA) after adjusting for baseline clinical characteristics and socio-demographics. Trajectories of the clinical outcome data at baseline, post-treatment and all follow-up time points will be plotted and compared with time series statistical analysis models with the other clinical and socio-demographic characteristics included as confounders., conditionsModule conditions: Depression, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Individually Neuronavigated accelerated intermittent theta burst stimulation with Magpro X100, outcomesModule primaryOutcomes measure: Montgomery-Åsberg Depression Rating Scale (MADRS), secondaryOutcomes measure: Quick Inventory of Depressive Symptomatology (16-Item) (Self-Report) (QIDS-16), secondaryOutcomes measure: Montreal Cognitive Assessment (MoCA),, secondaryOutcomes measure: EuroQol- 5 Dimension (EQ-5D), secondaryOutcomes measure: Quality of Life Enjoyment and Satisfaction Questionnaire Short form (Q-LES-QS-SF), otherOutcomes measure: Correlation of changes in functional connectivity with changes in MADRS scores, eligibilityModule sex: ALL, minimumAge: 21 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Institute of Mental Health, status: RECRUITING, city: Singapore, country: Singapore, contacts name: Phern-Chern Tor, MBBS, role: CONTACT, geoPoint lat: 1.28967, lon: 103.85007, hasResults: False