protocolSection identificationModule nctId: NCT06348771, orgStudyIdInfo id: Pro2023001579, briefTitle: Postprandial Inflammation and Nuts (PIN) in Older Adults, acronym: PIN, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-25, primaryCompletionDateStruct date: 2024-10-30, completionDateStruct date: 2025-01-30, studyFirstPostDateStruct date: 2024-04-05, lastUpdatePostDateStruct date: 2024-04-05, sponsorCollaboratorsModule leadSponsor name: Rutgers, The State University of New Jersey, class: OTHER, descriptionModule briefSummary: The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group. Legumes, such as peanuts, are a plant-based food high in protein and unsaturated fat making this a healthy choice, but are not consumed frequently enough in older adults. Studies have shown that regular nut consumption is associated with lower adiposity and reduced weight gain and inflammation. Given these findings, this study will examine the postprandial effects of meals with 2 levels of saturated fatty acids (SFA) on metabolic endotoxemia, inflammation and satiety, using a randomized cross-over design. The low SFA meal includes peanuts that are high in monounsaturated fatty acids (MUFA) and this will be compared to a high SFA meal. The results of this study have the potential to provide valuable insights into the role of peanuts in promoting health and preventing disease in at-risk older adults., conditionsModule conditions: Healthy Aging, conditions: Overweight and Obesity, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, interventionModelDescription: Higher SFA meal vs higher MUFA (nut) meal in individuals with overweight and obese, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 18, type: ESTIMATED, armsInterventionsModule interventions name: monounsaturated fatty acids (MUFA) peanut meal, outcomesModule primaryOutcomes measure: Concentration of Endotoxin, primaryOutcomes measure: Concentration of Interleukin-6, secondaryOutcomes measure: Concentration of Glucose and Insulin, secondaryOutcomes measure: Concentration of Triglyceride, secondaryOutcomes measure: Appetite, secondaryOutcomes measure: Concentration of Inflammatory markers, otherOutcomes measure: Concentration of zonulin, otherOutcomes measure: Lipid Profile, otherOutcomes measure: Characterization of the Microbiome, otherOutcomes measure: Concentration of incretin hormones, otherOutcomes measure: Concentration of Bone regulating markers, eligibilityModule sex: ALL, minimumAge: 55 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Foran Hall, status: RECRUITING, city: New Brunswick, state: New Jersey, zip: 08901, country: United States, contacts name: Sue Shapses, PhD, role: CONTACT, phone: 848-932-9403, email: shapses@rutgers.edu, contacts name: Rebecca Serrano, RD MPH, role: CONTACT, phone: 848-932-9403, email: rcjs@cinj.rutgers.edu, geoPoint lat: 40.48622, lon: -74.45182, locations facility: Rutgers University - NJ Inst Food Nutrition & Health, status: RECRUITING, city: New Brunswick, state: New Jersey, zip: 08901, country: United States, contacts name: Sue A Shapses, role: CONTACT, phone: 848-932-9403, email: shapses@rutgers.edu, geoPoint lat: 40.48622, lon: -74.45182, hasResults: False