protocolSection identificationModule nctId: NCT06283901, orgStudyIdInfo id: NL82013.018.22, briefTitle: Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness, acronym: IMPROVE-DOC, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-01-02, primaryCompletionDateStruct date: 2025-01-01, completionDateStruct date: 2025-09-01, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), class: OTHER, descriptionModule briefSummary: Patients with acute severe brain injury are usually admitted to the Intensive Care Unit. A substantial proportion of these patients will have disorders of consciousness (DOC) after interruption of sedation. It is difficult to reliably predict neurological outcome in these patients. Dependent on the extent of permanently damaged brain areas, DOC in patients with acute severe brain injury may improve or persist, eventually evolving into a minimal conscious state (MCS) or unresponsive wakefulness syndrome (UWS). These conditions are accompanied by long term severe disability. In current practice, the decision to withdraw life-sustaining support is made by interpreting the results of repeated bedside neurological examination and conventional CT-brain imaging. Reliable identification of patients with a possible good outcome, in whom treatment should not be withdrawn, is difficult. In this prospective observational cohort study we aim to identify patients with a good neurological outcome., conditionsModule conditions: Traumatic Brain Injury, conditions: Intracranial Hemorrhages, conditions: Subarachnoid Hemorrhage, conditions: Meningitis, conditions: Encephalitis, conditions: Stroke, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 160, type: ESTIMATED, outcomesModule primaryOutcomes measure: Glasgow Outcome Scale Extended, secondaryOutcomes measure: Glasgow Outcome Scale Extended, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Radboud UMC, status: RECRUITING, city: Nijmegen, state: Gelderland, zip: 6525 GA, country: Netherlands, contacts name: Astrid Hoedemaekers, role: CONTACT, geoPoint lat: 51.8425, lon: 5.85278, locations facility: Amsterdam UMC, status: RECRUITING, city: Amsterdam, state: Noord-Holland, zip: 1105 AZ, country: Netherlands, contacts name: Wolmet Haksteen, MD, role: CONTACT, phone: +31 020 - 566 9111, email: w.e.haksteen@amsterdamumc.nl, geoPoint lat: 52.37403, lon: 4.88969, locations facility: Haaglanden MC, locatie Westeinde, status: RECRUITING, city: Den Haag, state: Zuid-Holland, zip: 2512 VA, country: Netherlands, contacts name: Sefanja Achterberg, role: CONTACT, geoPoint lat: 52.07667, lon: 4.29861, locations facility: Erasmus MC, status: NOT_YET_RECRUITING, city: Rotterdam, state: Zuid-Holland, zip: 3015 GD, country: Netherlands, contacts name: Mathieu van der Jagt, role: CONTACT, geoPoint lat: 51.9225, lon: 4.47917, locations facility: UMC Groningen, status: NOT_YET_RECRUITING, city: Groningen, zip: 9713 GZ, country: Netherlands, contacts name: Joukje van der Naalt, role: CONTACT, geoPoint lat: 53.21917, lon: 6.56667, hasResults: False