protocolSection identificationModule nctId: NCT06321380, orgStudyIdInfo id: 38RC23.0381, briefTitle: Working Memory Functioning in Alzheimer's Disease and Vascular Dementia, acronym: MEMTRAV-COG, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2025-09, completionDateStruct date: 2025-10, studyFirstPostDateStruct date: 2024-03-20, lastUpdatePostDateStruct date: 2024-03-20, sponsorCollaboratorsModule leadSponsor name: University Hospital, Grenoble, class: OTHER, collaborators name: University Grenoble Alps, collaborators name: Université Savoie Mont Blanc, collaborators name: Centre National de la Recherche Scientifique, France, collaborators name: Laboratoire de Psychologie et NeuroCognition, descriptionModule briefSummary: The aim of the present study is to investigate potential cognitive mechanisms contributing to working memory impairment in Alzheimer's disease and vascular dementia. The investigators consider a new hypothesis suggesting that difficulties in mobilizing maintenance strategies of information could explain this working memory deficit. More specifically, the investigators assume that patient groups will have difficulties in employing both refreshing and elaborative strategies during a working memory task (i.e., complex span task), as compared to a control group., conditionsModule conditions: Alzheimer Disease, conditions: Vascular Dementia, conditions: Mixed Dementias, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 120, type: ESTIMATED, armsInterventionsModule interventions name: Complex span task, interventions name: Clinical neuropsychological assessment, interventions name: Clinical neurospychological assessement, outcomesModule primaryOutcomes measure: Memory performance in the Working memory task, primaryOutcomes measure: Processing performance in the Working memory task, primaryOutcomes measure: Reaction time, secondaryOutcomes measure: Mini-Mental State Examination (MMSE), secondaryOutcomes measure: Digit span forward WAIS IV (digit number), secondaryOutcomes measure: Digit span forward WAIS IV (standard note), secondaryOutcomes measure: Digit span backward WAIS IV (digit number), secondaryOutcomes measure: Digit span backward WAIS IV (standard note), secondaryOutcomes measure: Stroop Test - denomination part, secondaryOutcomes measure: Stroop Test - minor interference part (Time), secondaryOutcomes measure: Stroop Test - minor interference part (errors), secondaryOutcomes measure: Stroop Test - major interference part (time), secondaryOutcomes measure: Stroop Test - major interference part (errors), secondaryOutcomes measure: Trail Making Test - Part A (time), secondaryOutcomes measure: Trail Making Test - Part A (errors), secondaryOutcomes measure: Trail Making Test - Part B (time), secondaryOutcomes measure: Trail Making Test - Part B (errors), secondaryOutcomes measure: Category fluences, secondaryOutcomes measure: Memory evaluation (16-item Free and Cued Recall, or GERIA-12), secondaryOutcomes measure: Naming task, secondaryOutcomes measure: Behavior rating inventory of executive function, secondaryOutcomes measure: Instrumental Activities of Daily Living, secondaryOutcomes measure: Activities of Daily Living, eligibilityModule sex: ALL, minimumAge: 65 Years, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False