protocolSection identificationModule nctId: NCT06314607, orgStudyIdInfo id: APHP220498, briefTitle: Genetic and Molecular Characterization of Nervous System Lesions, acronym: ONCONEUROTEK 2, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-26, primaryCompletionDateStruct date: 2034-03, completionDateStruct date: 2034-03, studyFirstPostDateStruct date: 2024-03-18, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: Assistance Publique - Hôpitaux de Paris, class: OTHER, descriptionModule briefSummary: Primary and secondary brain tumors, the leading cause of death from cancer before the age of 35, represent a complex and heterogeneous group of pathologies with a generally poor prognosis. Knowledge of these tumors has made enormous strides thanks to access to biological samples, leading to a much more robust, reliable and precise histo-pronostic classification, but also, increasingly, to the identification of theranostic targets.Despite these advances, there is a real need to refine diagnostic and prognostic classification, identify the biological mechanisms involved in the formation and progression of these pathologies, develop new targeted strategies, and devise minimally invasive follow-up methods (liquid biopsies).In addition, certain non-tumoral brain lesions (e.g. malformations) can be similarly classified according to their molecular and mutational profile.This project aims to make a decisive contribution to these objectives., conditionsModule conditions: Brain Tumor, conditions: Brain Lesion (General), designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 10000, type: ESTIMATED, armsInterventionsModule interventions name: Prospective Biological Collection, interventions name: Retrospective Biological Collection, outcomesModule primaryOutcomes measure: Study the clinical markers with the evolution of brain lesions., primaryOutcomes measure: Study the biological markers with the evolution of brain lesions., primaryOutcomes measure: Study the anatomopathological markers with the evolution of brain lesions., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Service de Neurochirurgie - Hôpital de la Pitié Salpêtrière, status: RECRUITING, city: Paris, zip: 75013, country: France, contacts name: Bertand Mathon, Dr, role: CONTACT, phone: 01 84 82 73 63, phoneExt: +33, email: bertrand.mathon@aphp.fr, geoPoint lat: 48.85341, lon: 2.3488, locations facility: Service de Neurologie 2 -Hôpital de la Pitié Salpêtrière, status: RECRUITING, city: Paris, zip: 75013, country: France, contacts name: Marc Sanson, Prof, role: CONTACT, phone: 01 42 16 03 91, phoneExt: +33, email: marc.sanson@aphp.fr, geoPoint lat: 48.85341, lon: 2.3488, locations facility: Service de Radiothérapie - Hôpital de la Pittié Salpêtrière, status: NOT_YET_RECRUITING, city: Paris, zip: 75013, country: France, contacts name: Julian Jacob, Dr, role: CONTACT, phone: 01 84 82 74 90, phoneExt: +33, email: julian.jacob@aphp.fr, geoPoint lat: 48.85341, lon: 2.3488, hasResults: False