protocolSection identificationModule nctId: NCT06371209, orgStudyIdInfo id: 2022P000619, briefTitle: Kinematics of Ewing Amputees, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2022-05-17, primaryCompletionDateStruct date: 2024-06-29, completionDateStruct date: 2024-07-01, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Brigham and Women's Hospital, class: OTHER, descriptionModule briefSummary: The agonist-antagonist myoneural interface (AMI) construct, known as the Ewing amputation at the trans-tibial level, has been shown to create a bi-directional neural communication platform as a means of controlling and interpreting proprioceptive feedback from a prosthetic joint. In AMI constructs, agonist-antagonist muscles are mechanically coupled within the residual limb, and volitional contraction of an agonist passively stretches that muscle's antagonist. The natural neural responses from muscle spindles within both muscles are then interpreted by the central nervous system as sensations of joint position and speed, associated with movement of the prosthesis.The aim of this research protocol is to evaluate the electromyographic and kinematic patterns of participants who have undergone unilateral lower extremity Ewing Amputation in order to determine how similar their residual limb data is when compared to their intact limb data. A secondary aim of this research may include comparison of the Ewing participant cohort's biomechanical patterns to a similar cohort of participants who have undergone standard amputation.The investigators hypothesize that the affected limb of patients with the Ewing procedure will demonstrate a pattern of electromyographic activation of their AMI constructs and kinematic data that recapitulates the pattern seen in their intact limb. The investigators secondarily hypothesize that the kinematic assessment of Ewing Amputation patients will demonstrate patterns that are significantly more physiologic than those witnessed in similar assessments of standard amputees., conditionsModule conditions: Lower Extremity Amputation, conditions: Trans-Tibial Amputation, conditions: Traumatic Lower Extremity Amputation, conditions: Agonist-Antagonist Myoneural Interface, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 32, type: ESTIMATED, armsInterventionsModule interventions name: Modified Amputation, interventions name: Standard Amputation, outcomesModule primaryOutcomes measure: Duration of co-contraction of the ankle dorsi/plantar-flexor muscles during gait, primaryOutcomes measure: Symmetry of duration of co-contraction of the ankle dorsi/plantar-flexor muscles during gait, secondaryOutcomes measure: Symmetry of ankle power generation, secondaryOutcomes measure: Symmetry of peak knee flexion during stance, otherOutcomes measure: Symmetry of step length, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Mass General Brigham, city: Boston, state: Massachusetts, zip: 02129, country: United States, geoPoint lat: 42.35843, lon: -71.05977, hasResults: False