protocolSection identificationModule nctId: NCT06322888, orgStudyIdInfo id: 23-676, briefTitle: Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D), statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2025-09-30, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-03-21, lastUpdatePostDateStruct date: 2024-03-21, sponsorCollaboratorsModule leadSponsor name: Dana-Farber Cancer Institute, class: OTHER, collaborators name: Breast Cancer Research Foundation, descriptionModule briefSummary: The goal of this study is to learn more about how exercise might lower the risk of developing breast cancer in women with dense breast tissue by studying changes that occur in breast tissue and blood as a result of participating in an exercise program.The names of the study groups in this study are:* Exercise Training Group* Waitlist Control Group, conditionsModule conditions: Breast Cancer, conditions: Breast Cancer Female, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 46, type: ESTIMATED, armsInterventionsModule interventions name: Exercise Training Program, outcomesModule primaryOutcomes measure: Change in Irisin in Exercise Group, primaryOutcomes measure: Change in Irisin in Control Group, secondaryOutcomes measure: Change in Tissue Markers in Exercise Group, secondaryOutcomes measure: Change in Tissue Markers in Control Group, secondaryOutcomes measure: Change in Biomarkers in Exercise Group - Meso scale, secondaryOutcomes measure: Change in Biomarkers in Exercise Group - Mass cytometry, secondaryOutcomes measure: Change in Biomarkers in Control Group - Meso Scale, secondaryOutcomes measure: Change in Biomarkers in Control Group - Mass cytometry, secondaryOutcomes measure: Change in Participant Weight in Exercise Group, secondaryOutcomes measure: Change in Participant Weight in Control Group, secondaryOutcomes measure: Change in Cardiorespiratory Fitness in Exercise Group, secondaryOutcomes measure: Change in Cardiorespiratory Fitness in Control Group, secondaryOutcomes measure: 10-Repetition Max Test in Exercise Group, secondaryOutcomes measure: 10-Repetition Max Test in Control Group, secondaryOutcomes measure: Change in Minutes of Total Exercise for Exercise Group, secondaryOutcomes measure: Change in Minutes of Total Exercise for Control Group, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 59 Years, stdAges: ADULT, contactsLocationsModule locations facility: Brigham and Women's Hospital, city: Boston, state: Massachusetts, zip: 02115, country: United States, contacts name: Tari King, MD, role: CONTACT, phone: 617-632-3891, email: tking7@bwh.harvard.edu, contacts name: Tari King, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.35843, lon: -71.05977, locations facility: Dana Farber Cancer Institute, city: Boston, state: Massachusetts, zip: 02215, country: United States, contacts name: Jennifer Ligibel, MD, role: CONTACT, phone: 617-632-3800, email: Jennifer_Ligibel@dfci.harvard.edu, contacts name: Jennifer Ligibel, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.35843, lon: -71.05977, hasResults: False