hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06286397, orgStudyIdInfo id: 855173, briefTitle: Topical Anti-Androgens in Pilonidal Sinus Disease, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2027-05-01, completionDateStruct date: 2027-12-01, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: University of Pennsylvania, class: OTHER, descriptionModule briefSummary: The goal of this randomized clinical trial is to test the topical drug clascoterone in patients with pilonidal disease, which is a common, benign skin condition of the gluteal cleft. The main questions it aims to answer are:* Does clascoterone improve the severity of pilonidal disease as scored by a physician?* Does clascoterone improve patient symptoms due to pilonidal disease?* Does clascoterone improve the inflammation seen under the microscope in pilonidal disease removed at surgery Participants will apply clascoterone or a placebo cream to the diseased area for 3 months. They will be assessed every 4 weeks for disease severity assessed by a physician viewing patient photos and a symptom-based survey.Researchers will compare participants who received clascoterone treatment to those who received placebo., conditionsModule conditions: Pilonidal Disease, conditions: Pilonidal Disease of Natal Cleft, conditions: Pilonidal Sinus, conditions: Pilonidal Cyst, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized, Double-Blinded, Placebo-Controlled Trial, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 75, type: ESTIMATED, armsInterventionsModule interventions name: 1% Clascoterone, interventions name: Vehicle Cream, outcomesModule primaryOutcomes measure: Physician-Assessed Disease Severity Assessment, primaryOutcomes measure: Dermatology Life Quality Index, secondaryOutcomes measure: Subcutaneous Inflammation, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Pennsylvania, city: Philadelphia, state: Pennsylvania, zip: 19103, country: United States, contacts name: Lillias Maguire, MD, role: CONTACT, phone: 215-662-2078, email: lillias.maguire@pennmedicine.upenn.edu, contacts name: Lillias Maguire, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 39.95233, lon: -75.16379, hasResults: False
protocolSection identificationModule nctId: NCT06286384, orgStudyIdInfo id: LEMU47, briefTitle: Evaluating the Long-term Effects of Microfocused Ultrasound on Facial Tightening Using Quantitative Instruments, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-07-03, primaryCompletionDateStruct date: 2024-09-15, completionDateStruct date: 2025-03-15, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: First Affiliated Hospital of Jinan University, class: OTHER, descriptionModule briefSummary: By utilizing standardized photographs in conjunction with quantification detection instruments, data analysis before and after treatment is conducted, along with long-term efficacy observations. This approach aims to provide more comprehensive scientific evidence for the clinical application of ultrasound treatment in anti-aging therapy., conditionsModule conditions: Facial Aging, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 32, type: ESTIMATED, outcomesModule primaryOutcomes measure: Total Volume Change of Nasolabial Folds, primaryOutcomes measure: Change in Maximum Depth of Nasolabial Folds, primaryOutcomes measure: Vertical Elevation Value of Nasolabial Fold Curve Projection Curve, primaryOutcomes measure: Elevation Value of Nasolabial Fold Curve Projection Curve (Along the Nasal Wing Method, primaryOutcomes measure: Change in Mid-Facial Volume, primaryOutcomes measure: Brow Lift Height, eligibilityModule sex: FEMALE, minimumAge: 25 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: First Affiliated Hospital of Jinan University, status: RECRUITING, city: Guangzhou, state: Guangdong, zip: 510000, country: China, contacts name: Xuangu LI, role: CONTACT, phone: +8613825136477, email: 443747565@qq.com, geoPoint lat: 23.11667, lon: 113.25, hasResults: False
protocolSection identificationModule nctId: NCT06286358, orgStudyIdInfo id: P2023/346 / CCB : B40620230001, briefTitle: Aortopathy Relationship To Imagery and Kinocardiography Features (ARTIK), acronym: ARTIK, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-07, primaryCompletionDateStruct date: 2025-03-30, completionDateStruct date: 2025-09-30, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: Université Libre de Bruxelles, class: OTHER, collaborators name: Erasme University Hospital, descriptionModule briefSummary: Kinocardiography (KCG) is a portable measurement technique developed to estimate cardiac mechanical performance by studying the vibrations produced by myocardial contraction during each heartbeat and transmitted to the body surface.The goal of this observational study is to learn about kinocardiography in patients with aortic valve disease (AVD) or thoracic aortic aneurysm (TAA). The investigators believe that this technology will enable us to diagnose aortic valve disease and aortic aneurysm.In patients with AVD of different severities or TAA, the investigators will collect informations from echocardiography and/or cardiac magnetic resonance imaging and KCG recordings. Researchers will also compare subjects without any AVD nor TAA to better understand these effects on KCG., conditionsModule conditions: Aortic Valve Disease, conditions: Aortic Aneurysm, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 180, type: ESTIMATED, armsInterventionsModule interventions name: Kinocardiography, outcomesModule primaryOutcomes measure: Understand and assess the complex mechanisms underlying the modifications of KCG signals in patients with AVD and/or TAA, secondaryOutcomes measure: Comparing KCG to clinical assessment, secondaryOutcomes measure: Asses the clinical application of KCG to diagnose AVD and TAA, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Erasme hospital, status: RECRUITING, city: Brussels, zip: 1070, country: Belgium, contacts name: Philippe van de Borne, MD, PhD, role: CONTACT, phone: 2 555 39 60, phoneExt: +32, email: philippe.vandeborne@hubruxelles.be, contacts name: Philippe van de Borne, MD, PhD, role: PRINCIPAL_INVESTIGATOR, contacts name: Elza Abdessater, MD, role: SUB_INVESTIGATOR, geoPoint lat: 50.85045, lon: 4.34878, hasResults: False
protocolSection identificationModule nctId: NCT06286332, orgStudyIdInfo id: Interventional, briefTitle: Music Therapy in Acute Leukemia Patients With Fatigue, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2026-03-01, completionDateStruct date: 2026-03-01, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-06, sponsorCollaboratorsModule leadSponsor name: Chang Gung University, class: OTHER, descriptionModule briefSummary: The objective of this study is to assess the efficacy of employing music therapy in alleviating fatigue and medical laboratory values among patients with acute myeloid leukemia., conditionsModule conditions: Acute Myeloid Leukemia, conditions: Fatigue, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: DOUBLE, whoMasked: CARE_PROVIDER, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Music Therapy, outcomesModule primaryOutcomes measure: Change from baseline in fatigue on the Tang Fatigue Rating Scale (TFRS) and 11-point Numeric Rating Scale (NRS-11) at day 21., secondaryOutcomes measure: Change from baseline in neutrophil, hemoglobin, abumin at day 21., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06286319, orgStudyIdInfo id: 23-00726, briefTitle: Cold Oxygen Lung Preservation and Ventilation With the "Angel Cooler", statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2026-04, completionDateStruct date: 2026-04, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: NYU Langone Health, class: OTHER, descriptionModule briefSummary: The objective of this feasibility study is to evaluate continuous temperature monitoring, oxygen (O2) concentration and ventilation with positive end expiratory pressure (PEEP) to keep lungs cooled at 4-8 degrees Celsius, with continuous O2 concentration of 100% and inflated with a PEEP of 8-10 during the entire cold ischemic period., conditionsModule conditions: Lung Diseases, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: DEVICE_FEASIBILITY, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Angel Cooler, outcomesModule primaryOutcomes measure: Proportion of Devices Deemed "Functional", eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: NYU Langone Health, city: New York, state: New York, zip: 10016, country: United States, geoPoint lat: 40.71427, lon: -74.00597, hasResults: False
protocolSection identificationModule nctId: NCT06286293, orgStudyIdInfo id: 18171, briefTitle: YOD-RiSoCo: Social Cognition and Risky Decision-making in Patients With Young-onset Dementia, acronym: YOD-RiSoCo, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-01, primaryCompletionDateStruct date: 2026-06-30, completionDateStruct date: 2027-03-31, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: University Medical Center Groningen, class: OTHER, collaborators name: ZonMw: The Netherlands Organisation for Health Research and Development, descriptionModule briefSummary: The goal of this observational study is to learn about social cognition and risky behaviour in patients with young-onset dementia (YOD). The investigators want to* Examine differences in performance on social cognition test and measures of risky behaviour between behavioural variant YOD patients, patients with frontal brain injury, non-behavioural YOD patients and healthy controls.* Examine if there is a relation between social cognition tests and measures of risky behaviour.Participants will be administered a neuropsychological assessment including social cognition measures and patients will complete a driving simulator task in which risky behaviour will be elicited., conditionsModule conditions: Young-onset Dementia, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 140, type: ESTIMATED, armsInterventionsModule interventions name: Neuropsychological assessment, driving simulator task, outcomesModule primaryOutcomes measure: Social cognitive performance, secondaryOutcomes measure: Association between social cognition and risky decision-making, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06286280, orgStudyIdInfo id: AZ221/21, secondaryIdInfos id: F/23/22, type: OTHER_GRANT, domain: German Foundation of Heart Research, briefTitle: Removal Of CytoKines With cytoSorbenTs After Inflammatory Response Reaction During Cardiac Surgery, acronym: ROCKSTAR, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-05-01, primaryCompletionDateStruct date: 2024-12-01, completionDateStruct date: 2025-05-01, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-18, sponsorCollaboratorsModule leadSponsor name: University of Giessen, class: OTHER, collaborators name: Deutsche Stiftung für Herzforschung, descriptionModule briefSummary: Detailed knowledge about the association between systemic inflammation and endothelial progenitor cell (EPCs) activation during extracorporeal circulation (ECC) is lacking.This pilot study aims to clarify the relationship between CD34-positive EPCs and cytokine release during ECC using the cytokine adsorber to make a predictive statement regarding the clinical expression of inflammation., conditionsModule conditions: Inflammatory Response, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: single-center, two-arm randomized-controlled prospective study, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: SINGLE, maskingDescription: Participant will not be informed about group allocation, whoMasked: PARTICIPANT, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: cytokine adsorber (CytoSorb®), outcomesModule primaryOutcomes measure: correlation of endothelial progenitor cells with cytokine levels with and without adsorber use, secondaryOutcomes measure: Overall mortality rate, secondaryOutcomes measure: Days on ventilator, vasopressor and renal replacement therapy, secondaryOutcomes measure: incidence of stroke, secondaryOutcomes measure: length of ICU and in-hospital stay, secondaryOutcomes measure: Echocardiographic changes, secondaryOutcomes measure: Influence of Cytokine on endothelial progenitor cells, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Universityhospital Giessen, Department of Cardiovascular Surgery, status: RECRUITING, city: Giessen, zip: 35392, country: Germany, contacts name: Zulfugar T Taghiyev, MD, MBA, role: CONTACT, phone: 80064198556743, email: gk5019@uni-giessen.de, contacts name: Zulfugar T Taghiyev, MD, MBA, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 50.58727, lon: 8.67554, hasResults: False
protocolSection identificationModule nctId: NCT06286241, orgStudyIdInfo id: 877/2564(IRB2), briefTitle: Comparison of the Complications in Multiple Myeloma Patients Who Received Autologous Stem Cell Transplantation Between in HEPA-filtered Room and Non-HEPA-filtered Room, acronym: Step down ward, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-25, primaryCompletionDateStruct date: 2024-06-30, completionDateStruct date: 2024-07-30, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-15, sponsorCollaboratorsModule leadSponsor name: Siriraj Hospital, class: OTHER, collaborators name: Faculty of Medicine Siriraj Hospital, descriptionModule briefSummary: The goal of this observational study is to comparison of the complications in multiple myeloma patients who received autologous stem cell transplantation between in HEPA-filtered room and non-HEPA-filtered room. The main questions it aims to answer are:* The incidence of febrile neutropenia, infection, and duration of hospital stay* 2-year progression free survival Participants will be collected the data of baseline diagnosis, treatment, treatment results and complications during admission and follow-up visits from hospital medical record., conditionsModule conditions: Multiple Myeloma, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: OTHER, enrollmentInfo count: 344, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: febrile neutropenia, primaryOutcomes measure: Infection, primaryOutcomes measure: duration of admission, primaryOutcomes measure: progression free survival, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06286228, orgStudyIdInfo id: 751/2563(IRB4), briefTitle: Registry of Haploidentical Hematopoietic Stem Cell Transplantation in Adult With Hematologic Disease, acronym: Haplo, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2029-04-01, completionDateStruct date: 2030-04-01, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-01, sponsorCollaboratorsModule leadSponsor name: Siriraj Hospital, class: OTHER, collaborators name: Faculty of Medicine Siriraj Hospital, descriptionModule briefSummary: The goal of this observational study is to register hematologic patients with haploidentical hematopoietic stem cell transplantation (haploHSCT). The main questions it aims to answer are:* 1-year progression free survival rate* 1-year overall survival rate* Graft-versus-host free relapsed free survival at 30-day, 100-day, 180-day and 1-year* Chronic Graft-versus-host free relapsed free survival at 180-day and 1-year* Rate of Neutrophil and platelet engraftment* Efficacy of donor specific antibody desensitization* Relapsed rate* Primary and late graft failure* Safety and complication of haploHSCT* Complication of viral, bacterial, and fungal infection* Viral reactivation* Comparison outcomes between matched sibling donor (MSD) HSCT and matched unrelated donor (MUD) HSCT* Comparison cost-effectiveness of treatment between matched sibling donor (MSD) HSCT and matched unrelated donor (MUD) HSCT Participants will be collected the data of baseline diagnosis, treatment, treatment results of all admission and follow-up visits from hospital medical record., conditionsModule conditions: Multiple Myeloma, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 43, type: ESTIMATED, outcomesModule primaryOutcomes measure: register hematologic patients with haploidentical hematopoietic stem cell transplantation, secondaryOutcomes measure: progression free survival rate, secondaryOutcomes measure: overall survival rate, secondaryOutcomes measure: Chronic Graft-versus-host free relapsed free survival, secondaryOutcomes measure: Relapsed rate, secondaryOutcomes measure: Primary and late graft failure, secondaryOutcomes measure: Rate of Neutrophil and platelet engraftment, secondaryOutcomes measure: Efficacy of donor specific antibody desensitization, secondaryOutcomes measure: Safety and complication of haploHSCT, secondaryOutcomes measure: Complication of viral, bacterial, and fungal infection, secondaryOutcomes measure: Viral reactivation, secondaryOutcomes measure: outcomes between matched sibling donor (MSD) HSCT and matched unrelated donor (MUD) HSCT, secondaryOutcomes measure: cost-effectiveness of treatment between matched sibling donor (MSD) HSCT and matched unrelated donor (MUD) HSCT, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06286215, orgStudyIdInfo id: 586/2564(IRB2), briefTitle: Registry of Patients With Plasma Cell Disorders, acronym: Registry PCD, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2034-04-01, completionDateStruct date: 2035-04-01, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Siriraj Hospital, class: OTHER, collaborators name: Faculty of Medicine Siriraj Hospital, descriptionModule briefSummary: The goal of this observational study is to register patients with plasma cell disorders. The main questions it aims to answer are:* The incidence of plasma cell disorders both before and after malignancy* Time to progression of monoclonal gammopathy of undetermined significant (MGUS) or smoldering multiple myeloma (SMM) to light chain amyloidosis or multiple myeloma (MM)* Progression free survival (PFS)* overall survival* factors influencing overall survival, progression-free survival, and time to progression* Symptoms and signs of the disease during the diagnosis and relapse phases, including the causes of mortality in plasma cell disorder patients.* genetic characteristics of plasma cell disorder* cost-effectiveness of treatment in Thailand Participants will be collected the data of baseline diagnosis, treatment, treatment results of all admission and follow-up visits from hospital medical record., conditionsModule conditions: Plasma Cell Disorders, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 750, type: ESTIMATED, outcomesModule primaryOutcomes measure: register the plasma cell disorder patients, secondaryOutcomes measure: incidence of plasma cell disorders, secondaryOutcomes measure: Time to progression, secondaryOutcomes measure: Progression free survival, secondaryOutcomes measure: overall survival, secondaryOutcomes measure: influencing factors, secondaryOutcomes measure: Symptoms and signs, secondaryOutcomes measure: genetic characteristics, secondaryOutcomes measure: cost-effectiveness, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06286189, orgStudyIdInfo id: 2020P002760-t, briefTitle: Trazodone on OSA Endotypes, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2025-01-01, completionDateStruct date: 2025-06-01, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Brigham and Women's Hospital, class: OTHER, descriptionModule briefSummary: Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. Some OSA patients with low arousal threshold wake up prematurely during an obstructive event and do not have time for spontaneous upper airway (UA) dilator muscle recruitment. As a consequence they are exposed to apnea and hypopnea cycling. In this protocol the investigators will test the effect of trazodone administered before sleep on OSA traits and OSA severity during sleep., conditionsModule conditions: Obstructive Sleep Apnea, designModule studyType: INTERVENTIONAL, phases: PHASE1, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 18, type: ESTIMATED, armsInterventionsModule interventions name: Placebo oral tablet, interventions name: Trazodone Hydrochloride, outcomesModule primaryOutcomes measure: Effect of trazodone on arousal threshold (%eupnea), secondaryOutcomes measure: Effect of trazodone on apnea hypopnea index (events/h), eligibilityModule sex: ALL, minimumAge: 21 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Brigham and Women's Hospital, status: RECRUITING, city: Boston, state: Massachusetts, zip: 02115, country: United States, contacts name: Nicole Calianese, BS, role: CONTACT, phone: 617-732-8976, email: ncalianese@mgb.org, geoPoint lat: 42.35843, lon: -71.05977, hasResults: False