hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06281392, orgStudyIdInfo id: CEIm: 106/23, briefTitle: Artificial Intelligence and Dysplasia Detection in Inflammatory Bowel Disease (EIIDISIA Study), statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-15, primaryCompletionDateStruct date: 2026-11-15, completionDateStruct date: 2026-11-15, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, class: OTHER, collaborators name: University of Valencia, descriptionModule briefSummary: Randomized clinical study analyzing the efficacy of colonoscopy assisted by the Computer Aided Detection (CADe) system compared to virtual chromoendoscopy with Narrow Band Imaging (NBI) in the detection of colon dysplasia in patients with long-standing inflammatory bowel disease (IBD)., conditionsModule conditions: Inflammatory Bowel Diseases, conditions: Dysplasia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SCREENING, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 122, type: ESTIMATED, armsInterventionsModule interventions name: CADe system, interventions name: NBI, outcomesModule primaryOutcomes measure: "Per lesion" dysplasia detection rate (DDR), primaryOutcomes measure: "Per patient" dysplasia detection rate (DDR), secondaryOutcomes measure: Duration of endoscopic examination, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Antonio López-Serrano, status: RECRUITING, city: Valencia, zip: 46017, country: Spain, contacts name: Antonio López-Serrano, Ph.D., role: CONTACT, phone: 0034656495490, email: anlopezs@comv.es, geoPoint lat: 39.46975, lon: -0.37739, hasResults: False
protocolSection identificationModule nctId: NCT06281379, orgStudyIdInfo id: Basaksehir City Hospital, briefTitle: Complete Mesogastric Excision With D2 Lympadenectomy for Gastric Cancer:, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-04-01, primaryCompletionDateStruct date: 2023-12-31, completionDateStruct date: 2024-01-01, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Başakşehir Çam & Sakura City Hospital, class: OTHER_GOV, descriptionModule briefSummary: Objective: To define complete mesogastric excision and compare our short term results for the first time in a different population.Study design:Randomised-controlled studyPlace and duration of the study: Gastroenterological Surgery Clinic,Health Sciences University,Basaksehir City Hospital,Istanbul,Turkey,from April to December 2023.Methodology: We compared short term results of open total gastrectomy+ mesogastrectomy with standard total gastrectomy + D2 lymph node dissection at a tertiary center in terms of peroperative results, histopathological findings and postoperative short- term outcomes with review of the literature.Conclusion: Our aim is to show that mesogastric excision is safe and has advantages over conventional D2 gastrectomy in means of not only peroperative and short-term outcomes, but also disease free survival.Our work is the first study from a different population of the world and our initial results can contribute to the literature for universalization., conditionsModule conditions: Gastric Cancer, conditions: Gastric Neoplasm, conditions: Gastric Cancer Stage, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Study group participants: total gastrectomy+mesogastrectomy Control group: Standard total gastrectomy + D2 lymph node dissection, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 37, type: ACTUAL, armsInterventionsModule interventions name: Total mesogastrectomy, outcomesModule primaryOutcomes measure: Postoperative outcome, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Yigit Duzkoylu, city: Istanbul, zip: 34480, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06281366, orgStudyIdInfo id: PR(AMI)470-2023, briefTitle: Diamine Oxidase and Adverse Pregnancy Outcomes, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-16, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-03-20, sponsorCollaboratorsModule leadSponsor name: Hospital Universitari Vall d'Hebron Research Institute, class: OTHER, collaborators name: DR Healthcare, descriptionModule briefSummary: In normal pregnancies, blood histamine concentration remains within normal values; however, the serum histaminolytic activity is increased. Histamine is mainly produced by mast cells, platelets, basophils, neurons and enterochromatin cells, where it is stored and released when required. Reduced DAO activities have been found in high-risk pregnancies. Lower DAO activity has been associated to miscarriage, fetal demise, preeclampsia, low birthweight and preterm birth. The placenta is very rich in DAO activity and is the principal source of increased histaminolytic activity in normal pregnancies.First-trimester screening for preeclampsia (PE) is a routine screening which is performed in the first trimester. Women with a positive result are at a greater risk of PE but also other pregnancy complications such as stillbirth, preterm birth and low birthweight. These cases are prescribed aspirin until term. This intervention has demonstrated to significantly reduce the risk of PE and other complications. Unfortunately, aspirin does not avoid all cases with adverse outcomes, indicating that additional mechanisms may be involved in the development of such pregnancy complications, such as DAO decreased activity., conditionsModule conditions: Pregnancy Complications, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 75, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Diamine oxidase activity first trimester, primaryOutcomes measure: Diamine oxidase gene polymorphisms, secondaryOutcomes measure: Blood Diamine oxidase activity at delivery, secondaryOutcomes measure: Placental Diamine oxidase activity at delivery, secondaryOutcomes measure: Blood histamine levels at delivery, secondaryOutcomes measure: Placental histamine levels at delivery, secondaryOutcomes measure: Urine histamine levels at delivery, eligibilityModule sex: FEMALE, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Manel Mendoza, status: RECRUITING, city: Barcelona, zip: 08035, country: Spain, contacts name: Manel Mendoza, PhD, role: CONTACT, phone: +34934893085, email: manel.mendoza@vallhebron.cat, contacts name: Erika Bonacina, PhD, role: CONTACT, phone: +34934893264, email: erika.bonacina@vallhebron.cat, contacts name: Erika Bonacina, PhD, role: SUB_INVESTIGATOR, contacts name: Manel Mendoza, PhD, role: PRINCIPAL_INVESTIGATOR, contacts name: Mireia Armengol, MD, role: SUB_INVESTIGATOR, geoPoint lat: 41.38879, lon: 2.15899, hasResults: False
protocolSection identificationModule nctId: NCT06281340, orgStudyIdInfo id: He-ankle US, briefTitle: Changes in Intra-articular Parameters by Doppler Ultrasound in Patients With Hemophilic Ankle Arthropathy, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-02-28, primaryCompletionDateStruct date: 2024-04-10, completionDateStruct date: 2024-04-21, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Investigación en Hemofilia y Fisioterapia, class: NETWORK, descriptionModule briefSummary: Introduction: Hemophilic ankle arthropathy is manifested by functional degenerative alterations, intra-articular alterations, and chronic pain. Manual therapy techniques are used in the treatment of hemophilic ankle arthropathy for the improvement of pain and mobility.Design. Double-blind randomized pilot trial. Aimed: To evaluate the ultrasound changes by means of Doppler imaging after manual therapy intervention.Patients: A total of 20 adult patients with hemophilic ankle arthropathy will be recruited.Intervention: Each manual therapy session will last approximately 50 minutes, with 1 session per week for a period of 3 weeks. The treatment program includes 10 techniques that will be administered bilaterally.Measuring instruments: Patients will be evaluated qualitatively with ultrasound (HEAD-US scale) and assessment with Doppler ultrasound. The clinical variables will be joint damage (Hemophilia Joint Health Score) and pain intensity (Visual Analogue Scale).Expected results: Check the safety of manual therapy in patients with hemophilia regarding subclinical bleeding. Assess changes related to joint inflammatory state with imaging techniques. Observe changes in pain intensity and joint damage., conditionsModule conditions: Hemophilia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: DIAGNOSTIC, maskingInfo masking: DOUBLE, maskingDescription: Randomization will be performed using a computerized randomization procedure by permuted blocks of 4 subjects in each recruitment center. The 6 possible sequence alternatives will be modified in each block. This task will be carried out by a person who is not involved in the study and who will not know the identity of the subjects., whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Manual therapy, interventions name: Placebo therapy, outcomesModule primaryOutcomes measure: Change from baseline sonographic changes after 4 hours, secondaryOutcomes measure: Change from baseline joint pain after 4 hours, secondaryOutcomes measure: Change from baseline joint damage after 4 hours, secondaryOutcomes measure: Change from baseline degree of joint inflammation after 4 hours, eligibilityModule sex: MALE, minimumAge: 30 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: University of Oviedo, city: Oviedo, state: Asturias, zip: 33006, country: Spain, geoPoint lat: 43.36029, lon: -5.84476, hasResults: False
protocolSection identificationModule nctId: NCT06281327, orgStudyIdInfo id: TX-ITP-001, briefTitle: Avatrombopag in the Treatment of Pediatric Immune Thrombocytopenia, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2025-12, completionDateStruct date: 2025-12, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Institute of Hematology & Blood Diseases Hospital, China, class: OTHER, collaborators name: Henan Cancer Hospital, collaborators name: Tianjin Medical University Second Hospital, collaborators name: Tianjin Children's Hospital, collaborators name: The Second Affiliated Hospital of Kunming Medical University, descriptionModule briefSummary: To evaluate the safety and efficacy of avatrombopag in the treatment of pediatric primary immune thrombocytopenia in patients who have been treated with eltrombopag before and switched to avatrobopag because of poor efficacy, excessive platelet fluctuation or intolerance, or patient preference, economic reasons, and other reasons., conditionsModule conditions: Immune Thrombocytopenia, conditions: Treatment, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Avatrombopag, outcomesModule primaryOutcomes measure: Overall efficacy response after AVA treatment within 12 weeks, secondaryOutcomes measure: Treatment response-1, secondaryOutcomes measure: Treatment response-2, secondaryOutcomes measure: Time to Response, secondaryOutcomes measure: Persistent response, secondaryOutcomes measure: Emergency treatment, secondaryOutcomes measure: Reduction of concomitant drug, secondaryOutcomes measure: Number of participants with clinically significant bleeding as assessed using the world health organization (WHO) bleeding scale., secondaryOutcomes measure: Number of participants with clinically significant bleeding as assessed using the bleeding scale for pediatric patients with ITP., secondaryOutcomes measure: Health-related quality of life survey of subjects(HRQoL)-1, secondaryOutcomes measure: Health-related quality of life survey of subjects(HRQoL)-2, secondaryOutcomes measure: Health-related quality of life survey of subjects(HRQoL)-3, secondaryOutcomes measure: Health-related quality of life survey of subjects(HRQoL)-4, eligibilityModule sex: ALL, minimumAge: 6 Years, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, status: RECRUITING, city: Tianjin, country: China, contacts name: Lei Zhang, MD, role: CONTACT, phone: +8602223909009, email: zhanglei1@ihcams.ac.cn, contacts name: Ting Sun, MD, role: CONTACT, phone: +8602223909009, email: sunting@ihcams.ac.cn, geoPoint lat: 39.14222, lon: 117.17667, hasResults: False
protocolSection identificationModule nctId: NCT06281314, orgStudyIdInfo id: VESPA 2.0, briefTitle: The Efficacy of VESPA 2.0 for Cognitive Rehabilitation in Patients With Mild Cognitive Impairment, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-03-01, primaryCompletionDateStruct date: 2022-12-27, completionDateStruct date: 2023-12-31, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: IRCCS Centro Neurolesi "Bonino-Pulejo", class: OTHER, descriptionModule briefSummary: VESPA 2.0 is based on an integrative and ecological approach used for the treatment of cognitive dysfunction in patients with MCI or other neurodegenerative disorders., conditionsModule conditions: Neurodegenerative Diseases, conditions: Cognitive Decline, conditions: Parkinson Disease Dementia, conditions: Alzheimer Disease, conditions: Multiple Sclerosis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 60, type: ACTUAL, armsInterventionsModule interventions name: Vespa software, outcomesModule primaryOutcomes measure: Montreal cognitive assessment (MoCA), eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: IRCCS Centro Neurolesi Bonino Pulejo, city: Messina, state: Sicily, zip: 98124, country: Italy, geoPoint lat: 38.19394, lon: 15.55256, hasResults: False
protocolSection identificationModule nctId: NCT06281301, orgStudyIdInfo id: HSC-MS-23-1023, briefTitle: Improving Patient Understanding of Macrosomia, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-30, primaryCompletionDateStruct date: 2024-04-30, completionDateStruct date: 2024-09-01, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: The University of Texas Health Science Center, Houston, class: OTHER, descriptionModule briefSummary: The purpose of this study is to evaluate the effectiveness of a graphic based education tool on patient knowledge of macrosomia through the use of a survey and to evaluate knowledge at 1-2 weeks after initial review of the education tool., conditionsModule conditions: Macrosomia, Fetal, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 176, type: ESTIMATED, armsInterventionsModule interventions name: education tool, interventions name: no additional information, outcomesModule primaryOutcomes measure: Number of participants that showed Macrosomia knowledge greater than 50 percent as assessed by the score on a survey, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: The University of Texas Health Science Center at Houston, status: RECRUITING, city: Houston, state: Texas, zip: 77030, country: United States, contacts name: Kristen Cagino, MD, role: CONTACT, phone: 713-500-6412, email: Kristen.A.Cagino@uth.tmc.edu, contacts name: Suneet Chauhan, role: CONTACT, email: mfmchauhan@gmail.com, geoPoint lat: 29.76328, lon: -95.36327, hasResults: False
protocolSection identificationModule nctId: NCT06281288, orgStudyIdInfo id: P.T.REC/012/004754, briefTitle: Cognitive-Behavioral Therapy With Exercise Training in Adolescent Females With Elevated Depression Symptoms, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2023-12-25, primaryCompletionDateStruct date: 2024-03, completionDateStruct date: 2024-03, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: Doaa Tammam Atia, class: OTHER, descriptionModule briefSummary: PURPOSE: To Study the Effect of Cognitive-behavioral therapy combined with exercise training in adolescent females with elevated depression symptomsBACKGROUND: Teenagers are more likely than any other age group to experience psychological issues due to depression, Adolescents have gotten active attention from society for their mental health difficulties since they are a high-level reserve talent stratum in society. Adolescent depression rates have increased in recent years, and "silent killers" are preying on them. Teenagers are more likely than any other age group to experience psychological issues due to depression, Adolescents have gotten active attention from society for their mental health difficulties since they are a high-level reserve talent stratum in society. Adolescent depression rates have increased in recent years, and "silent killers"RESEARCH QUESTION: Is there is an effect of exercise on depression in adolescent girls., conditionsModule conditions: Depression, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: FACTORIAL, primaryPurpose: PREVENTION, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Cognitive-Behavioral Therapy, interventions name: Exercise Training, outcomesModule primaryOutcomes measure: Center for Epidemiological Studies Depression Scale for Children (CES-DC),, eligibilityModule sex: FEMALE, minimumAge: 12 Years, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: doaa Tammam Atia, city: Suez, country: Egypt, geoPoint lat: 29.97371, lon: 32.52627, hasResults: False
protocolSection identificationModule nctId: NCT06281275, orgStudyIdInfo id: TJ-IRB202402008, briefTitle: A Study of the Association Between Frailty and Acute Postoperative Pain in Elderly Thoracoscopic Surgery Patients, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-12, primaryCompletionDateStruct date: 2024-09-30, completionDateStruct date: 2024-10-30, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-04-12, sponsorCollaboratorsModule leadSponsor name: Huazhong University of Science and Technology, class: OTHER, descriptionModule briefSummary: To gain a clearer understanding of the association between frailty and postoperative acute pain in elderly thoracoscopic surgery patients and its underlying mechanisms, to provide new solution ideas to reduce the level of postoperative acute pain and improve the debilitating state of elderly thoracoscopic surgery patients, and consequently improve their quality of life and mental status., conditionsModule conditions: Frailty, conditions: Acute Postoperative Pain, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 78, type: ESTIMATED, outcomesModule primaryOutcomes measure: All patients' Numerical Rating Scale （NRS） scores for most significant pain at rest in the 48h postoperative period, primaryOutcomes measure: Numerical Rating Scale （NRS） scores for the most pronounced pain in the patient's coughing state in the 48h postoperative period, secondaryOutcomes measure: PCA pump consumption, secondaryOutcomes measure: Number of PCA pump presses, eligibilityModule sex: ALL, minimumAge: 60 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, city: Wuhan, state: Hubei, zip: 430030, country: China, geoPoint lat: 30.58333, lon: 114.26667, hasResults: False
protocolSection identificationModule nctId: NCT06281262, orgStudyIdInfo id: GIP-23-L-04-223, briefTitle: Selected Immunological Indicators and Microbiota in Patients With Premature Birth and Preeclampsia, acronym: PRIME, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-06-30, primaryCompletionDateStruct date: 2025-03-30, completionDateStruct date: 2025-03-30, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-03-01, sponsorCollaboratorsModule leadSponsor name: General University Hospital, Prague, class: OTHER, collaborators name: Charles University, Czech Republic, collaborators name: Institute of Hematology and Blood Transfusion, Czech Republic, descriptionModule briefSummary: The goal is to demonstrate the relationship of the circulating pool of T-regulatory lymphocytes in the mother's peripheral blood with populations in the placentas and to compare with controls, what is the difference in the expression of individual regulatory molecules of T-regulatory lymphocytes according to new paradigms. The proportional and functional characteristics of T-regulatory lymphocytes will be correlated with the composition of the intestinal and vaginal microbiota., conditionsModule conditions: Preterm Birth, conditions: Preeclampsia, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Peripheral blood collection, interventions name: Swab sample collection, outcomesModule primaryOutcomes measure: Changes in selected T cell subpopulations in the first trimester associated with subsequent spontaneous preterm birth, primaryOutcomes measure: Changes in selected T cell subpopulations in the first trimester associated with subsequent pre-eclampsia, secondaryOutcomes measure: Association of maternal microbiota and maternal T regulatory cell populations., eligibilityModule sex: FEMALE, minimumAge: 19 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule locations facility: Department of Gynaecology, Obstetrics and Neonatology of the First Faculty of Medicine of the Charles University and General University Hospital in Prague, status: RECRUITING, city: Prague, zip: 128 08, country: Czechia, contacts name: Zdeněk Laštůvka, MUDr., Ph.D., role: CONTACT, phone: +420777724640, email: zdenek.lastuvka@vfn.cz, contacts name: Michal Koucký, Doc., MUDr., Ph.D., role: CONTACT, phone: +420603219916, email: michal.koucky@vfn.cz, geoPoint lat: 50.08804, lon: 14.42076, hasResults: False