protocolSection identificationModule nctId: NCT06276335, orgStudyIdInfo id: IRAS:322440, briefTitle: Influence of Timing of Implant Placement on Early Healing Molecular Events, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2026-04-30, completionDateStruct date: 2026-05-30, studyFirstPostDateStruct date: 2024-02-23, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: Queen Mary University of London, class: OTHER, collaborators name: University of Zurich, descriptionModule briefSummary: Dental implants have been on the market for several years and they are routinely used to replace single/multiple missing teeth with a high success rate. However, there is still a limited number of studies comparing the influence of timing of implant placement on wound healing. In addition, there is no data available on the signaling pathways and the expression of healing biomarkers involved in the early stages of osseointegration after immediate implant placement (IP) or delayed implant placement (DP).The primary objective of this study is to describe changes in the expression of inflammatory, angiogenesis and osseous biomarkers of saliva at 1, 3, 7, 15 and 30 days and of PICF at 3, 7, 15 and 30 days after immediate implant placement (IP) compared with delayed placement (DP)., conditionsModule conditions: Dental Implant, conditions: Healing Wound, conditions: Biomarkers, conditions: Saliva, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 24, type: ESTIMATED, armsInterventionsModule interventions name: Immediate implant placement and guided bone regeneration (Test), interventions name: Late implant placement and guided bone regeneration (Control), outcomesModule primaryOutcomes measure: Changes in the expression of inflammatory, angiogenesis and osseous biomarkers of PICF and saliva, secondaryOutcomes measure: Blood flow changes, secondaryOutcomes measure: Soft tissue volume changes, secondaryOutcomes measure: Peri-implant bone level, secondaryOutcomes measure: Full mouth plaque score (FMPS), secondaryOutcomes measure: Full mouth bleeding score (FMBS), secondaryOutcomes measure: Probing pocket depth (PPD), secondaryOutcomes measure: Gingival recession (REC), secondaryOutcomes measure: Clinical attachment level (CAL), secondaryOutcomes measure: Suppuration, secondaryOutcomes measure: Patient satisfaction at 6 months after loading, secondaryOutcomes measure: Changes in the pink esthetic score (PES), secondaryOutcomes measure: Changes in the white esthetic score (WES), secondaryOutcomes measure: Changes in the papilla fill index (PFI), secondaryOutcomes measure: Implant survival, eligibilityModule sex: ALL, minimumAge: 25 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Centre for Oral Clinical Research, city: London, zip: E1 2AD, country: United Kingdom, contacts name: Nikolaos Donos, DDS MS PhD, role: CONTACT, phone: +44(0)2078823063, email: BHNT.Clinicaloralresearchcentre@nhs.net, contacts name: Vandana Luthra, Dr, role: CONTACT, phone: +44(0)2078826348, email: BHNT.Clinicaloralresearchcentre@nhs.net, contacts name: Nikolaos Donos, DDS MS PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 51.50853, lon: -0.12574, hasResults: False