protocolSection identificationModule nctId: NCT06296875, orgStudyIdInfo id: KAMM, briefTitle: The Krill Ageing Muscle Mechanisms (KAMM) Study, acronym: KAMM, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2026-03, completionDateStruct date: 2026-03, studyFirstPostDateStruct date: 2024-03-06, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: University of Glasgow, class: OTHER, descriptionModule briefSummary: This study aims to determine the mechanisms via which krill oil supplementation increases muscle strength and whether this translates to improvements in gait and functional characteristics in older adults. The studies we will carry out will establish, in healthy older adults, the effects of 6 months of supplementation with krill oilObjective 1) Muscle structure and function Hypothesis: Krill oil supplementation will increase muscle size and strength alongside positive changes in muscle architecture (pennation angle and fascicle length).Objective 2) Neuromuscular control and central nervous system (CNS) function Hypothesis: Krill oil supplementation will improve Neuromuscular Junction (NMJ) transmission stability and increase central drive and intramuscular coherence, as a measure of muscle synergy.Objective 3) Gait and functional characteristics Hypothesis: Krill oil supplementation will improve gait and functional characteristics., conditionsModule conditions: Sarcopenia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: 1:1 parallel group design, primaryPurpose: PREVENTION, maskingInfo masking: TRIPLE, maskingDescription: All supplements will be matched for taste and look, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Vegetable oil, interventions name: Krill oil, outcomesModule primaryOutcomes measure: Grip strength, primaryOutcomes measure: Neuromuscular junction transmission instability, primaryOutcomes measure: Gait speed, secondaryOutcomes measure: Knee extensor maximal torque, secondaryOutcomes measure: Vastus lateralis muscle cross sectional area, secondaryOutcomes measure: Vastus lateralis pennation angle, secondaryOutcomes measure: Vastus lateralis fascicle length, secondaryOutcomes measure: Erythrocyte fatty acid composition, secondaryOutcomes measure: Knee extensor force steadiness, secondaryOutcomes measure: Vastus lateralis motor unit conduction velocity, secondaryOutcomes measure: Vastus lateralis and vastus medialis intramuscular coherence, secondaryOutcomes measure: Hand flexor muscles intermuscular coherence, secondaryOutcomes measure: Cortico-muscular coherence between sensory motor cortex and hand extensor muscles, secondaryOutcomes measure: Femoral Nerve Stimulation, secondaryOutcomes measure: Transcranial Magnetic Stimulation (TMS), secondaryOutcomes measure: TMS Inhibition, secondaryOutcomes measure: TMS Excitation, secondaryOutcomes measure: Gait characteristics during 4m walk test and the timed up and go test, secondaryOutcomes measure: Gait cycle with leg support parameters, eligibilityModule sex: ALL, minimumAge: 65 Years, maximumAge: 90 Years, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Glasgow, city: Glasgow, country: United Kingdom, geoPoint lat: 55.86515, lon: -4.25763, hasResults: False