protocolSection identificationModule nctId: NCT06318689, orgStudyIdInfo id: 2023/0211/OB, briefTitle: In Situ Exploration of Vascular Function in Vasoplegic Shock Following Cardiac Surgery With Cardiopulmonary Bypass, acronym: Vaso-shock, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-05, primaryCompletionDateStruct date: 2026-02-05, completionDateStruct date: 2026-05-05, studyFirstPostDateStruct date: 2024-03-19, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: University Hospital, Rouen, class: OTHER, descriptionModule briefSummary: The goal of this observational study is to assess in situ vascular function, glycocalyx and microcirculation in postoperative vasoplegic shock following cardiac surgery with cardiopulmonary bypass.The main question is to investigate the relationship between NO-dependent vasomotor reserve and the presence of vasoplegic shock following cardiac surgery with cardiopulmonary bypass.Participants will have two visits, during which a number of non-invasive examinations will be carried out to study glycocalyx, microcirculation and vascular function. Biological and morphological data will be collected up to 3 months after inclusion, as well as information on treatments administered and outcome.Researchers will compare a group of patients with vasoplegic shock against a group without vasoplegic shock in order to study possible alterations in function in the vasoplegic shock group., conditionsModule conditions: Cardiac Surgical Procedures, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 124, type: ESTIMATED, outcomesModule primaryOutcomes measure: Association between the percentage of brachial artery variation measured by the flow-mediated vasodilation method and the presence of vasoplegic shock at incusion., secondaryOutcomes measure: Association between the percentage of brachial artery variation measured by the flow-mediated vasodilation method and the presence of vasoplegic shock at 48 hours., secondaryOutcomes measure: Pefused boundary region (PBR, µm) obtained from Glycocheck with the presence of vasoplegic shock., secondaryOutcomes measure: Microvascular blood flow (10^3 microns^3 / sec / mm^2) obtained from Glycocheck with the presence of vasoplegic shock, secondaryOutcomes measure: Total density (number of 10 micron long vessel segments with diameter of 4 to 25 microns per tissue surface area /mm^2) obtained from Glycocheck with the presence of vasoplegic shock, secondaryOutcomes measure: Endothelial function markers (Endothelin-1, pg/mL) with the presence of vasoplegic shock, secondaryOutcomes measure: Endothelial function markers (syndecan-1, pg/mL) with the presence of vasoplegic shock, secondaryOutcomes measure: Endothelial function markers (interleukin-6, pg/mL) with the presence of vasoplegic shock, secondaryOutcomes measure: Endothelial function markers (VCAM-1, pg/mL) with the presence of vasoplegic shock, secondaryOutcomes measure: Multivariate analysis explaining the occurrence of vasoplegic shock., secondaryOutcomes measure: Multivariate analysis explaining the occurrence of an altered perfused boundary region (µm)., eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Rouen University Hospital, status: RECRUITING, city: Rouen, state: Normandie, zip: 76000, country: France, contacts name: Emmanuel Besnier, MD, PhD, role: CONTACT, phone: 33232881705, email: emmanuel.besnier@chu-rouen.fr, contacts name: Domitille Renard, MD, role: CONTACT, phone: 33232881705, email: domitille.renard@chu-rouen.fr, geoPoint lat: 49.44313, lon: 1.09932, hasResults: False