protocolSection identificationModule nctId: NCT06281444, orgStudyIdInfo id: i07-453-23, briefTitle: Effectiveness of Radial Extracorporeal Shock Wave Therapy in Patients With Knee Osteoarthritis, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2025-01-31, completionDateStruct date: 2025-07-31, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Ankara University, class: OTHER, descriptionModule briefSummary: Osteoarthritis (OA) is a degenerative joint disease characterized by unsuccessful repair of joint damage resulting from stresses in any of the synovial joint tissues. Symptoms include pain (initially only after movement), joint stiffness, limitation of joint movement, feeling of insecurity in the joint, and difficulty walking. The diagnosis of knee osteoarthritis can be easily made with a detailed history and a comprehensive physical examination. Radiographic examinations are used to support clinical findings and exclude other possible pathologies. The main purpose of treating knee osteoarthritis is to reduce pain and make daily life easier. Since there is no standard treatment method, the patient's treatment must be individualized by taking into account age, comorbidity, severity of the clinical picture, patient preferences and cost of treatment. Conservative treatment includes pharmacological and non-pharmacological treatment, and the optimal treatment should be applied as a combination of these two methods. Patient education, lifestyle modification, exercise, different physical therapy modalities (TENS, Interferential current, ESWT...), acupuncture are some non-pharmacological methods.Extracorporeal shock wave therapy (ESWT), which is considered within the scope of conservative treatment, started in the seventies with the practice of breaking ureteric stones and has become one of the physical therapy modalities used in the treatment of various musculoskeletal diseases. Considering the historical development of ESWT, it has started to be used as a therapeutic modality in the treatment of knee osteoarthritis in recent years. The process, which started with animal experiments, continued with human studies, and evidence is presented that ESWT reduces knee pain and contributes to functionality. It is noteworthy that there are few studies and their short follow-up periods. In the light of these studies, it was planned to investigate the effectiveness of ESWT treatment, which will be applied together with exercise, on pain, functionality and walking distance in individuals diagnosed with knee osteoarthritis, in comparison with the control group receiving sham ESWT., conditionsModule conditions: Knee Osteoarthritis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Patients who accepted to participate in the study by meeting the criteria will be randomly divided into two groups as the first group treatment ESWT + exercise, the second group sham ESWT + exercise., primaryPurpose: TREATMENT, maskingInfo masking: NONE, maskingDescription: Patients who meet the study conditions and agree to participate in this study will not know whether they are in the first group or the second group., enrollmentInfo count: 72, type: ESTIMATED, armsInterventionsModule interventions name: ESWT, interventions name: Sham-ESWT, outcomesModule primaryOutcomes measure: Change in pain [by using the Visual Analogue Scale(VAS)], secondaryOutcomes measure: Change from baseline in functionality and walking distance, secondaryOutcomes measure: Change from baseline in walking distance, eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 85 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Ankara University, status: RECRUITING, city: Ankara, state: Altındağ, zip: 06230, country: Turkey, contacts name: Birkan Sonel Tur, Prof. Dr., role: CONTACT, phone: +903125956331, email: sonelb@medicine.ankara.edu.tr, contacts name: Taha Can Başar, Dr., role: CONTACT, phone: +90312595 6331/2822, email: tahacan06@outlook.com, contacts name: Birkan Sonel Tur, Prof. Dr., role: PRINCIPAL_INVESTIGATOR, contacts name: Taha Can Başar, Dr., role: SUB_INVESTIGATOR, geoPoint lat: 39.91987, lon: 32.85427, hasResults: False