protocolSection identificationModule nctId: NCT06353035, orgStudyIdInfo id: NaturalResourcesIFinland, secondaryIdInfos id: 346136, type: OTHER_GRANT, domain: Strategic Research Council Finland, secondaryIdInfos id: 346138, type: OTHER_GRANT, domain: Strategic Research Council Finland, briefTitle: Biodiversity Interventions for Well-Being, acronym: BIWE, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2022-03-30, primaryCompletionDateStruct date: 2027-06-30, completionDateStruct date: 2027-09-30, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: Natural Resources Institute Finland, class: OTHER_GOV, collaborators name: Tampere University, descriptionModule briefSummary: Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities, which weakens the functionality of the urban ecosystems and the well-being of citizens. This may also increase the risk of immune-mediated disorders among urban dwellers.In Biodiversity interventions for well-being (BIWE), microbial biodiversity interventions are performed to increase biodiversity in urban built areas. Results from the intervention trials are combined with publicly available land cover and ecological data. These are analyzed from the viewpoint of shifts in ecosystems and human well-being and immune regulation, ecological quality, and urban planning.The investigators set up an intervention study in which urban private yards are rewilded with diverse vegetation and decaying deadwood and plant residuals. The investigators aim to evaluate the effect of rewilding, and yard management practices on commensal microbiome, cortisol levels and well-being and salivary cytokine levels, and gene pathways., conditionsModule conditions: Microbial Colonization, conditions: Immune System Diseases, conditions: Well-Being, Psychological, conditions: Nature, Human, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Intervention-control study in which intervention study subjects private yards are rewilded and control receives no treatment., primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, maskingDescription: The research subjects were not randomized or masked to the intervention and control group, because the control group needs volunteers who have no intention of following the yard management instructions advised to the intervention group., enrollmentInfo count: 30, type: ACTUAL, armsInterventionsModule interventions name: Rewilding, outcomesModule primaryOutcomes measure: Skin Gammaproteobacteria, secondaryOutcomes measure: Salivary cytokines, secondaryOutcomes measure: Difference in diversity (Alpha and beta diversity) of skin, saliva and stool microbiota, secondaryOutcomes measure: Difference in observed species richness of skin, saliva and stool microbiota, secondaryOutcomes measure: Difference in taxonomies of skin, saliva and stool microbiota, secondaryOutcomes measure: Difference in microbial gene pathways of saliva and stool microbiota, secondaryOutcomes measure: Cortisol levels, secondaryOutcomes measure: Perceived Stress Scale, secondaryOutcomes measure: Warwick-Edinburgh Mental Wellbeing Scale, secondaryOutcomes measure: Depression Scale, secondaryOutcomes measure: Nature Relatedness Scale, secondaryOutcomes measure: Metabolites in urine, otherOutcomes measure: Associations between environmental factors and microbial measurements, salivary cytokine levels, hair cortisol levels, perceived well-being, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 72 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Natural Resources Institute Finland, city: Helsinki, state: Uusimaa, zip: 00970, country: Finland, geoPoint lat: 60.16952, lon: 24.93545, hasResults: False