hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06386653, orgStudyIdInfo id: [123I]I-DARPIN-Ec1, briefTitle: Molecular Imaging of EpCAM Receptors Using [123I]I-DARPIN-Ec1, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2024-05-14, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Tomsk National Research Medical Center of the Russian Academy of Sciences, class: OTHER, collaborators name: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, collaborators name: Uppsala University, descriptionModule briefSummary: The study should evaluate the biological distribution of \[123I\]I-DARPIN-Ec1 in patients with lung and ovarian cancerThe primary objective are:1. To assess the distribution of \[123I\]I-DARPIN-Ec1 in normal tissues and tumors at different time intervals.2. To evaluate dosimetry of \[123I\]I-DARPIN-Ec1 .3. To study the safety and tolerability of the drug \[123I\]I-DARPIN-Ec1 after a single injection in a diagnostic dosage.The secondary objective are:1. To compare the obtained \[123I\]I-DARPIN-Ec1 SPECT imaging results with the data of CT and/or MRI and/or ultrasound examination and immunohistochemical (IHC) studies in lung and ovarian cancer patients., conditionsModule conditions: Lung Cancer, conditions: Ovarian Cancer, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: DIAGNOSTIC, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: Diagnostic Test: whole body study and SPECT with [123I]I-DARPIN-Ec1, outcomesModule primaryOutcomes measure: Gamma camera-based whole-body [123I]I-DARPIN-Ec1 uptake value (%), primaryOutcomes measure: SPECT-based [123I]I-DARPIN-Ec1 value in tumor lesions (counts), primaryOutcomes measure: SPECT-based [123I]I-DARPIN-Ec1 uptake value (counts), primaryOutcomes measure: Tumor-to-background ratio (SPECT), secondaryOutcomes measure: Percent of cases with abnormal findings in physical examination, vital signs and ECG associated with [123I]I-DARPIN-Ec1 injections., secondaryOutcomes measure: Percent of cases with abnormal laboratory test results associated with [123I]I-DARPIN-Ec1 injections associated with [123I]I-DARPIN-Ec1 injections., secondaryOutcomes measure: Incidence and severity of adverse events associated with [123I]I-DARPIN-Ec1 injections, secondaryOutcomes measure: Percent of cases requiring administration of concomitant medication due to [123I]I-DARPIN-Ec1 injections, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: TomskNRMC, city: Tomsk, country: Russian Federation, geoPoint lat: 56.49771, lon: 84.97437, hasResults: False
protocolSection identificationModule nctId: NCT06386640, orgStudyIdInfo id: 0784, briefTitle: A Holistic Patient-centred Intervention to Improve Outcomes of Older People Living With Frailty and Chronic Heart Failure, acronym: FIT-HF, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-01-27, primaryCompletionDateStruct date: 2025-04-30, completionDateStruct date: 2025-04-30, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: University of Leicester, class: OTHER, descriptionModule briefSummary: Two-centre complex intervention development and feasibility trial using mixed qualitative and quantitative approach, conditionsModule conditions: Chronic Heart Failure, conditions: Frailty, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Intervention Development, outcomesModule primaryOutcomes measure: Phase I: Qualitative evaluation with stakeholders to identify gaps in current HF care pathway leading to unmet healthcare needs in older people living with frailty and CHF, primaryOutcomes measure: Phase II: Co-design and production of a holistic, patient-centered intervention addressing various healthcare needs of older people living with frailty and CHF, primaryOutcomes measure: Phase IIa: Time spent in sedentary, light, moderate and vigorous activity over monitoring duration, primaryOutcomes measure: Phase III: Change in physical function as assessed by the SPPB upon completion of 12-week intervention and at 6 month follow up (this may alter depending on findings from Phase II), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 100 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Glenfield Hospital, status: RECRUITING, city: Leicester, country: United Kingdom, contacts name: Shirley Sze, role: CONTACT, email: kyss1@leicester.ac.uk, geoPoint lat: 52.6386, lon: -1.13169, hasResults: False
protocolSection identificationModule nctId: NCT06386627, orgStudyIdInfo id: Skoltech-CNBR3, secondaryIdInfos id: 21-75-30024, type: OTHER_GRANT, domain: Russian Science Foundation, briefTitle: Study of Neurophysiological Markers of Motor Recovery in Post-stroke Patients., statusModule overallStatus: COMPLETED, startDateStruct date: 2023-07-01, primaryCompletionDateStruct date: 2024-03-15, completionDateStruct date: 2024-03-15, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Skolkovo Institute of Science and Technology, class: OTHER, collaborators name: Federal center of brain research and neurotechnologies, FMBA, Moscow, Russia, descriptionModule briefSummary: The aim of the study was to explore potential pathways for recovery and adaptation of neural pathways after stroke by examining electrical activity of the brain cortex and cortico-spinal excitability using transcranial magnetic stimulation in people with motor impairment after stroke. Participants in the study performed a simple stimulus-response task with a healthy and a paralysed limb several times at different stages of basic rehabilitation. To compare the data, a group of healthy volunteers took part in a similar experiment. We recorded cortical activity using electroencephalography and muscle activity using electromyography. After the stimulus-response task, we also carried out a study using transcranial magnetic stimulation to assess the integrity of corticospinal connections., conditionsModule conditions: Stroke, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 40, type: ACTUAL, armsInterventionsModule interventions name: Stimulus response task, interventions name: Transcranial magnetic stimulation, outcomesModule primaryOutcomes measure: Atypical shape of lateralized readiness potential, secondaryOutcomes measure: Absent of ipsilateral muscles contraction in response to primary motor cortex stimulation in both hemispheres, eligibilityModule sex: ALL, minimumAge: 30 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Skolkovo Institute of Science and Technology (Skoltech), city: Moscow, country: Russian Federation, geoPoint lat: 55.75222, lon: 37.61556, hasResults: False
protocolSection identificationModule nctId: NCT06386614, orgStudyIdInfo id: BDNF, briefTitle: Effects of TDCS of the Frontal Lobe on Cognitive Function and BDNF in PSCI, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-01-01, primaryCompletionDateStruct date: 2024-06-01, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: The Second Affiliated Hospital of Dalian Medical University, class: OTHER, descriptionModule briefSummary: The purpose of the clinical trial is to find a treatment for stroke patients with cognitive impairment, and the main questions it aims to answer are:* \[Search for effective treatments of cognitive impairment after stroke\]* \[explore the relationship between BDNF level and cognitive function\] Participants will receive conventional treatment, tDCS treatment, .And then compare cognitive function and BDNF level, conditionsModule conditions: Stroke, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Routine treatment, interventions name: Transcranial Direct Current Stimulation, outcomesModule primaryOutcomes measure: BDNF, secondaryOutcomes measure: Cognitive function level, secondaryOutcomes measure: Executive function level, secondaryOutcomes measure: Memory function level, eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Department of Rehabilitation Medicine, the Second Hospital of Dalian Medical University, status: COMPLETED, city: DaLian, state: Liaoning, zip: 116021, country: China, geoPoint lat: 38.91222, lon: 121.60222, locations facility: Lily, status: RECRUITING, city: Dalian, state: Liaoning, zip: 116021, country: China, contacts name: Yang Tu, role: CONTACT, phone: 18875214238, email: 715700399@qq.com, geoPoint lat: 38.91222, lon: 121.60222, hasResults: False
protocolSection identificationModule nctId: NCT06386588, orgStudyIdInfo id: 2024P000610, briefTitle: The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2027-06-30, completionDateStruct date: 2027-12-31, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Massachusetts General Hospital, class: OTHER, descriptionModule briefSummary: In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights. On some nights the headbands will play soft sounds at specific times during sleep. The investigators are interested in learning whether this timed auditory stimulation may be a strategy to improve the coordination of sleep rhythms across brain regions, improve network communication, and as a result, improve memory. The investigators will study 30 adults aged 18-45 with schizophrenia and 30 demographically matched healthy controls. Participants will first have a daytime MRI scan, during which they will complete a finger tapping motor sequence task (MST), followed by a week of sleep at home with a sleep headband. They will also do the MST at home on two of the nights. On the final day of the study, participants will return for a second MRI scan., conditionsModule conditions: Schizophrenia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Closed loop auditory stimulation during sleep, outcomesModule primaryOutcomes measure: Changes in sleep physiology, primaryOutcomes measure: Changes in functional connectivity of the hippocampus and thalamus, primaryOutcomes measure: Changes in hippocampal activation during motor sequence task (MST), primaryOutcomes measure: Changes in hippocampal microstructural integrity, secondaryOutcomes measure: Greater gains in typing speed over rest breaks during MST training (micro-offline gains), secondaryOutcomes measure: Sleep dependent memory consolidation (SDMC), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: Massachusetts General Hospital, city: Charlestown, state: Massachusetts, zip: 02129, country: United States, contacts name: Dara Manoach, PhD, role: CONTACT, phone: 617-724-6148, email: manoachlab@gmail.com, contacts name: Lindsey Jones, MS, role: CONTACT, phone: 617-702-2368, email: manoachlab@gmail.com, contacts name: Dara Manoach, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 42.37787, lon: -71.062, hasResults: False
protocolSection identificationModule nctId: NCT06386575, orgStudyIdInfo id: suprainguinal, briefTitle: Suprainguinal Fascia Iliaca Block in Knee Arthroplasty, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2024-08-01, completionDateStruct date: 2024-09-01, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: Konya City Hospital, class: OTHER, descriptionModule briefSummary: Total knee arthroplasty is the most commonly performed orthopedic surgery, especially in patients with advanced gonarthrosis and limited joint movement. After total knee arthroplasty, patients experience unbearably severe pain. Pain that is not adequately treated in the postoperative period increases the stress response in patients, increases the risk of embolism, causes bleeding in the surgical area, and causes undesirable conditions such as agitation and delirium in patients. This postoperative pain is successfully treated with various variants of multimodal analgesia., conditionsModule conditions: Analgesia, conditions: Anesthesia, Local, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Suprainguinal fascia iliaca block will be applied to the patients at the end of the surgery., primaryPurpose: OTHER, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: control group; Patients who received physiological saline, interventions name: suprainguinal fascia block; Patients receiving local anesthetic, outcomesModule primaryOutcomes measure: quality of recovery-15T, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06386549, orgStudyIdInfo id: HSEARS20220424001, briefTitle: Effect of a Tele-rehabilitation Programme in Children With Burns: a Randomized Controlled Trial, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-11-14, primaryCompletionDateStruct date: 2024-10-31, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: LIAO Peng, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to compare tele-rehabilitation and routine post-discharge rehabilitation in children with burn injuries. The main questions it aims to answer are:* Is tele-rehabilitation better for improving the quality and outcomes of care for burn children?* Is tele-rehabilitation more effective in improving scar management in children with burns injuries?* Is tele-rehabilitation more effective in improving perceived stress in parents of children with burns injuries?, conditionsModule conditions: Burns, conditions: Tele-rehabilitation, conditions: Scar, conditions: Children, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 44, type: ESTIMATED, armsInterventionsModule interventions name: tele-rehabilitation, outcomesModule primaryOutcomes measure: The scars of children with burns, primaryOutcomes measure: The quality and outcomes of care for burn children, secondaryOutcomes measure: psychological stress of caregvers, eligibilityModule sex: ALL, minimumAge: 3 Years, maximumAge: 6 Years, stdAges: CHILD, contactsLocationsModule locations facility: Hongkong Poly Uiniversity, status: RECRUITING, city: Hong Kong, country: China, contacts name: Fu Jinfeng, role: CONTACT, phone: +8613987695500, email: fujinfeng@etyy.cn, geoPoint lat: 22.39407, lon: 114.13737, documentSection largeDocumentModule largeDocs typeAbbrev: ICF, hasProtocol: False, hasSap: False, hasIcf: True, label: Informed Consent Form, date: 2022-05-31, uploadDate: 2024-04-17T21:22, filename: ICF_000.pdf, size: 59989, hasResults: False
protocolSection identificationModule nctId: NCT06386536, orgStudyIdInfo id: 2023-1796, briefTitle: Development and Evaluation of TRIVEL Smart Bike Training Prescription Programs., statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-15, primaryCompletionDateStruct date: 2024-05, completionDateStruct date: 2024-05, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Sylvie Nadeau, class: OTHER, descriptionModule briefSummary: This pilot A-B study aims to develop and validate personalized training programs for older adults with decreased mobility on a Semi-Reclining Intelligent Stationary Bike prototype.The study also aims to assess the feasibility and acceptability of the training programs and to document their preliminary effects on physical health, perceived well-being, and quality of life. Ten participants will take part in five personalized training sessions with the intelligent bike and five standard training sessions with a traditional stationary bike., conditionsModule conditions: Aging, conditions: Mobility Limitation, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, interventionModelDescription: A single-subject reversal study design (A-B) will be used. During the A and B phases, the participants will undergo training with either the VI-TRIVEL or a conventional stationary bike., primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: Intelligent stationary bike, interventions name: Conventional stationary bilke, outcomesModule primaryOutcomes measure: Walking ability and functional capacity, primaryOutcomes measure: Leg strength and endurance, secondaryOutcomes measure: Well-being, secondaryOutcomes measure: Quality of life, eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 95 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: L'Institut de réadaptation Gingras-Lindsay-de-Montréal, status: RECRUITING, city: Montréal, state: Quebec, zip: H3S 2J4, country: Canada, contacts name: Sylvie Nadeau, PhD, role: CONTACT, phone: 5143436111, phoneExt: 12253, email: sylvie.nadeau@umontreal.ca, contacts name: Roua Walha, PhD, role: CONTACT, phone: 8199195095, email: roua.walha@umontreal.ca, contacts name: Sylvie Nadeau, PhD, role: PRINCIPAL_INVESTIGATOR, contacts name: Roua Walha, PhD, role: SUB_INVESTIGATOR, contacts name: Julie Soulard, PhD, role: SUB_INVESTIGATOR, contacts name: Cyril Duclos, PhD, role: SUB_INVESTIGATOR, contacts name: Nicolas Berryman, PhD, role: SUB_INVESTIGATOR, contacts name: Elaine Deguise, PhD, role: SUB_INVESTIGATOR, contacts name: Claudine Auger, PhD, role: SUB_INVESTIGATOR, contacts name: Dahlia Kairy, PhD, role: SUB_INVESTIGATOR, contacts name: David Labbé, PhD, role: SUB_INVESTIGATOR, contacts name: Rachid Aissaoui, PhD, role: SUB_INVESTIGATOR, contacts name: Gabriel Moisan, PhD, role: SUB_INVESTIGATOR, geoPoint lat: 45.50884, lon: -73.58781, hasResults: False
protocolSection identificationModule nctId: NCT06386523, orgStudyIdInfo id: 23-AOI-03, briefTitle: Standardization of a New Psychophysical Olfactory Test, TODA2, acronym: TODA-STAR, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-15, primaryCompletionDateStruct date: 2024-05-23, completionDateStruct date: 2025-11-15, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Centre Hospitalier Universitaire de Nice, class: OTHER, descriptionModule briefSummary: Recruitment of patients consulting the IUFC for another pathology unrelated to an olfactory disorder:Interview and clinical examination and Passing the 2 olfactory tests for 30 voluntary's patients, a second consultation of 15 minutes including the time of the test within 7 days after the 1st, conditionsModule conditions: Patients Without an Olfactory Disorder, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 112, type: ESTIMATED, armsInterventionsModule interventions name: Passage of olfactory tests, outcomesModule primaryOutcomes measure: Passage of olfactory tests:, primaryOutcomes measure: Passage of olfactory tests:, primaryOutcomes measure: Passage of olfactory tests:, secondaryOutcomes measure: Identify confounding factors, i.e. factors that can influence the results of the olfactory test, secondaryOutcomes measure: Identify confounding factors, i.e. factors that can influence the results of the olfactory test, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 99 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False