protocolSection identificationModule nctId: NCT06342323, orgStudyIdInfo id: IRB00006761-M2023235, secondaryIdInfos id: ONFM-SBRT, type: OTHER, domain: Peking university third hospital, briefTitle: The Optimal Number of Fiducial Marker for Stereotactic Body Radiotherapy, acronym: ONFM-SBRT, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-10-08, primaryCompletionDateStruct date: 2024-10-07, completionDateStruct date: 2025-10-07, studyFirstPostDateStruct date: 2024-04-02, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Peking University Third Hospital, class: OTHER, descriptionModule briefSummary: This is a clinical study focused on the use of fiducial marker-guided stereotactic body radiotherapy (SBRT) for treating malignant tumors, including lung, liver, pancreatic, and kidney/adrenal cancers. Here's a breakdown of the key components of the study:Study Design: Prospective, single-center, exploratory clinical study.Patient Enrollment: The study intends to enroll patients diagnosed with malignant tumors requiring fiducial marker-guided SBRT. Each tumor type (lung, liver, pancreatic, kidney/adrenal) aims to include 15 cases.Informed Consent: Patients are required to sign informed consent before participating in the study, indicating their understanding of the procedures, risks, and benefits involved.Intervention: Enrolled patients will undergo stereotactic radiotherapy for their respective malignant tumors. During this process, fiducial markers will be implanted according to the study protocol.Monitoring: Following implantation of fiducial markers, the study will monitor adverse events associated with the procedure. This includes any complications or side effects resulting from the marker implantation process.Success Rate: The study will assess the success rate of fiducial marker implantation. This likely involves evaluating the accuracy and reliability of marker placement for guiding SBRT treatment.SBRT Treatment Error: The study will also monitor SBRT treatment errors. This involves tracking any deviations or inaccuracies in the delivery of stereotactic radiotherapy, potentially caused by issues such as improper fiducial marker placement or technical errors in treatment administration.Overall, the study aims to explore the feasibility and effectiveness of using fiducial marker-guided SBRT for treating various types of malignant tumors to assess both the safety and the efficacy with a focus on patient outcomes and treatment accuracy., conditionsModule conditions: Lung Cancer, conditions: Liver Cancer, conditions: Pancreatic Cancer, conditions: Renal Cell Carcinoma, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 57, type: ESTIMATED, armsInterventionsModule interventions name: SBRT, outcomesModule primaryOutcomes measure: success rate, secondaryOutcomes measure: Treatment error, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Peking University Third Hospital, status: RECRUITING, city: Beijing, state: Beijing, zip: 100191, country: China, contacts name: Qiu Bin, role: CONTACT, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False