hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06332664, orgStudyIdInfo id: 2023-2330, briefTitle: Early Nutrition Intervention for M1 Stage Cancer Patients, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2025-01-01, completionDateStruct date: 2025-07-01, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: Xingchen Peng, class: OTHER, descriptionModule briefSummary: In China, the treatment of advanced-stage cancer often follows a pattern where the management of patients is primarily overseen by oncologists who focus on addressing the main clinical symptoms and intervening accordingly.However, symptoms such as appetite loss, weight loss, and anxiety are often overlooked. It is common for clinical nutritionists to passively enter oncology wards to conduct comprehensive nutritional assessments and develop nutrition plans only when patients exhibit significant malnutrition, upon request from oncologists or patients and their families.Against this background, the investigators integrated clinical nutritionists into the oncology treatment team and established a proactive nutritional intervention team specifically targeting M1 advanced-stage cancer patients. This initiative aims to conduct a single-center, open-label, randomized parallel-group prospective study, with the following objectives: 1) to evaluate the impact of this model on the nutritional status, survival, and quality of life of advanced-stage cancer patients, and 2) to further optimize this model for widespread replication in clinical practice., conditionsModule conditions: Nutrition, conditions: Cancer Metastatic, designModule studyType: INTERVENTIONAL, phases: EARLY_PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 194, type: ESTIMATED, armsInterventionsModule interventions name: Early Nutrition Intervention, outcomesModule primaryOutcomes measure: the incidence of cachexia, secondaryOutcomes measure: overall survival ；progression-free survival, secondaryOutcomes measure: Physical Fitness Status, secondaryOutcomes measure: BMI, secondaryOutcomes measure: Nutritional risk and malnutrition status, secondaryOutcomes measure: Patient's emotional changes, secondaryOutcomes measure: Caregiver psychological burden, secondaryOutcomes measure: Patient's physical, social, and cognitive functioning, secondaryOutcomes measure: incidence of Sarcopenia, secondaryOutcomes measure: Nutritional risk and malnutrition status, secondaryOutcomes measure: Patient's emotional changes, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: West China Hospital, Sichuan Universit, status: RECRUITING, city: Chengdu, state: Sichuan, zip: 610041, country: China, contacts name: XingChen Peng, Ph.D, role: CONTACT, phone: +8618980606753, email: pxx2014@163.com, geoPoint lat: 30.66667, lon: 104.06667, hasResults: False
protocolSection identificationModule nctId: NCT06332651, orgStudyIdInfo id: NL84684.091.23, briefTitle: Metabolic Availability in Older and Younger Men, acronym: YOMA, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-19, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2025-04-01, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: Wageningen University, class: OTHER, descriptionModule briefSummary: The main goal of this study is to determine the metabolic availability of methionine in black beans, lysine in sorghum and lysine in milk using the indicator amino acid oxidation method both in older and in younger men., conditionsModule conditions: Ageing, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: It is a parallel intervention study. The intervention does not involve a drug or biologic product, however does involve an adaptation diet and a diet with measured amino acids dissolved in water, during the test day. We investigate the amino acid metabolic availability using the IAAO method., primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 28, type: ESTIMATED, armsInterventionsModule interventions name: Black beans, interventions name: Milk, interventions name: Sorghum, outcomesModule primaryOutcomes measure: Metabolic availability of methionine in black beans and lysine in milk and sorghum measured with the indicator amino acid oxidation method., eligibilityModule sex: MALE, minimumAge: 20 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Wageningen University & Research, status: RECRUITING, city: Wageningen, state: Gelderland, zip: 6708PB, country: Netherlands, contacts name: Fenna Hinssen, MSc, role: CONTACT, phone: +031648043165, email: yoma@wur.nl, contacts name: Karen Fransen, MSc, role: CONTACT, phone: +031648043165, email: yoma@wur.nl, geoPoint lat: 51.97, lon: 5.66667, hasResults: False
protocolSection identificationModule nctId: NCT06332638, orgStudyIdInfo id: IN_APA_124, briefTitle: PK, PD and Safety of Tegoprazan 12.5 mg After Oral Administration in Healthy Subjects, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2024-03-19, primaryCompletionDateStruct date: 2024-07-31, completionDateStruct date: 2024-07-31, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: HK inno.N Corporation, class: INDUSTRY, descriptionModule briefSummary: The primary objective of this study is to explore pharmacokinetics, pharmacodynamics, and safety of tegoprazan 12.5 mg in healthy subjects when orally administered as a single dose or as multiple doses twice daily., conditionsModule conditions: Healthy, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 36, type: ESTIMATED, armsInterventionsModule interventions name: Tegoprazan 12.5mg, interventions name: Tegoprazan 25mg, interventions name: Famotidine 20mg, outcomesModule primaryOutcomes measure: Cmax of tegoprazan and tegoprazan's metabolite M1, primaryOutcomes measure: AUC0-t of tegoprazan and tegoprazan's metabolite M1, primaryOutcomes measure: AUC0-∞ of tegoprazan and tegoprazan's metabolite M1, primaryOutcomes measure: Tmax of tegoprazan and tegoprazan's metabolite M1, primaryOutcomes measure: t1/2β of tegoprazan and tegoprazan's metabolite M1, primaryOutcomes measure: CL/F of tegoprazan, primaryOutcomes measure: Vd/F of tegoprazan, primaryOutcomes measure: Css,max of tegoprazan and tegoprazan's metabolite M1, primaryOutcomes measure: Css,min of tegoprazan and tegoprazan's metabolite M1, primaryOutcomes measure: Css,avg of tegoprazan and tegoprazan's metabolite M1, primaryOutcomes measure: AUCtau,ss of tegoprazan and tegoprazan's metabolite M1, primaryOutcomes measure: Tmax,ss of tegoprazan and tegoprazan's metabolite M1, primaryOutcomes measure: t1/2β,ss of tegoprazan and tegoprazan's metabolite M1, primaryOutcomes measure: CLss/F of tegoprazan, primaryOutcomes measure: Vdss/F of tegoprazan, primaryOutcomes measure: Accumulation index of tegoprazan, primaryOutcomes measure: Fluctuation of tegoprazan, secondaryOutcomes measure: 24-hour, daytime and nighttime mean pH, secondaryOutcomes measure: 24-hour, daytime and nighttime median pH, secondaryOutcomes measure: 24-hour, daytime and nighttime TpH>3(%), secondaryOutcomes measure: 24-hour, daytime and nighttime TpH>4(%), secondaryOutcomes measure: 24-hour, daytime and nighttime Δ TpH>3(%), secondaryOutcomes measure: 24-hour, daytime and nighttime Δ TpH>4(%), secondaryOutcomes measure: 24-hour, daytime and nighttime Δ mean pH, secondaryOutcomes measure: 24-hour, daytime and nighttime Δ median pH, eligibilityModule sex: ALL, minimumAge: 19 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: Inje University Busan Paik Hospital, city: Busan, zip: 47392, country: Korea, Republic of, geoPoint lat: 35.10278, lon: 129.04028, hasResults: False
protocolSection identificationModule nctId: NCT06332599, orgStudyIdInfo id: rjhy20240001, briefTitle: Minocycline for Helicobacter Pylori Rescue Treatment, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-10-01, primaryCompletionDateStruct date: 2024-04-30, completionDateStruct date: 2034-06-30, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: Shanghai Jiao Tong University School of Medicine, class: OTHER, descriptionModule briefSummary: Current guidelines have recommended classical bismuth-containing quadruple therapy including proton-pump inhibitor, bismuth, tetracycline, metronidazole as the empirical rescue therapy. However, tetracycline is clinically unavailable in China and the high frequency of adverse events of bismuth quadruple therapy often result in poor compliance, which limited the applicability of this recommendation. We previously showed that the efficacy of bismuth-containing quadruple therapy with minocycline and metronidazole was not inferior to classical bismuth quadruple therapy for refractory H. pylori infection, though also accompanied with high occurrence of adverse events.This study aimed to evaluate the efficacy and tolerability of four different regimens with minocycline and metronidazole compared to classical bismuth quadruple therapy for H. pylori rescue treatment in a real-world setting., conditionsModule conditions: Helicobacter Pylori Infection, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: RETROSPECTIVE, enrollmentInfo count: 600, type: ESTIMATED, armsInterventionsModule interventions name: BQT, interventions name: EBM4M4, interventions name: EBM3M3, interventions name: EBM2M4, interventions name: EBM2M3, outcomesModule primaryOutcomes measure: Helicobacter pylori eradication rate, secondaryOutcomes measure: Rate of adverse effects, secondaryOutcomes measure: Compliance rate, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Renji Hospital, School of Medicine, Shanghai Jiao Tong University, status: RECRUITING, city: Shanghai, state: None Selected, zip: 200127, country: China, contacts name: Yu Huang, role: CONTACT, phone: 0198621791879, email: 15626211482@163.com, geoPoint lat: 31.22222, lon: 121.45806, hasResults: False
protocolSection identificationModule nctId: NCT06332586, orgStudyIdInfo id: 202311087RINA, briefTitle: The Learning Effect of Applying Diversified Teaching in Emergency Injury Classification -Taking the Emergency Nurse of a Regional Hospital in Yunlin County as an Example, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2024-03-25, primaryCompletionDateStruct date: 2024-04-04, completionDateStruct date: 2024-05-05, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: National Taiwan University Hospital, class: OTHER, descriptionModule briefSummary: "Triage" is the first process of emergency treatment. It is mainly based on the severity of the disease and the appropriate allocation of limited people, time, place, and medical resources. It is very important and related to the quality of medical care. In order to accurately judge the severity of patients, reduce the individual errors of artificial memory and increase the consistency of the judgment of triage levels, the new emergency five-level triage classification standard (Taiwan Triage and Acuity Scale) was implemented in 2010., TTAS), the purpose is to allocate medical resources in the most appropriate manner at the appropriate time. It has been revised many times so far, so correct injury classification can maximize the safety of people's lives. This article reviews the relevant literature and finds that to have an efficient injury classification so that each patient receives appropriate medical allocation, an organized, effective and systematic injury inspection process structure is needed to enable the injury nurse to perform correct inspections. Injury skills and cognition should be actively promoted, and this policy must require traumatization nurses to continuously update their traumatization cognition and skills, and must also continue to conduct regular assessments and reviews to continuously improve the quality of traumatization grading by traumatization nurses. It can be seen that triage nurses must have skills, knowledge, attitudes and systems to improve the accuracy of triage levels and ensure the treatment of patients who need priority treatment . Therefore, this study can be used to understand the learning effectiveness of trauma care before and after diversified teaching, which can be used as a basis for teaching new trauma care nurses., conditionsModule conditions: Triage, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 22, type: ESTIMATED, armsInterventionsModule interventions name: Diversified teaching, outcomesModule primaryOutcomes measure: Improving the injury diagnosis ability of triage diagnosis nurses through diversified teaching, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Taiwan, city: Taipei, zip: Taiwan, country: Taiwan, geoPoint lat: 25.04776, lon: 121.53185, hasResults: False
protocolSection identificationModule nctId: NCT06332547, orgStudyIdInfo id: TICVS, briefTitle: Transfusion in Cardiac Valve Surgery, acronym: TICVS, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2027-12-30, completionDateStruct date: 2027-12-30, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: Guangdong Provincial People's Hospital, class: OTHER, descriptionModule briefSummary: This prospective, randomized controlled study is aimed to figure out suitable transfusion threshold in patients undergoing cardiac valve surgery under cardiopulmonary bypass(CPB). Patients are randomly assigned to restrictive and liberal transfusion group and receive blood transfusion during and after surgery. Compare primary and secondary outcomes of two groups., conditionsModule conditions: Cardiac Surgery With Cardiopulmonary Bypass, conditions: Valve Heart Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, enrollmentInfo count: 1600, type: ESTIMATED, armsInterventionsModule interventions name: Restrictive Transfusion Strategy, interventions name: Liberal Transfusion Strategy, outcomesModule primaryOutcomes measure: A composite of postoperative morbidity and mortality, secondaryOutcomes measure: Rate of reoperation, secondaryOutcomes measure: Length of ICU Stays, secondaryOutcomes measure: Length of Postoperative Hospital Stay, secondaryOutcomes measure: Number of Blood Transfusion, secondaryOutcomes measure: Duration of mechanical ventilation, secondaryOutcomes measure: Postoperative thoracic fluid volume in the first 24 hours, secondaryOutcomes measure: Number of participants with postoperative atrial fibrillation, secondaryOutcomes measure: Number of participants with new-onset renal failure with dialysis, secondaryOutcomes measure: Number of participants with acute kidney injury, secondaryOutcomes measure: Number of participants with delirium, secondaryOutcomes measure: Hospitalization expense, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Guangdong Provincial People's Hospital, city: Guangzhou, state: Guangdong, zip: 510145, country: China, contacts name: Huang Huanlei, Phd, role: CONTACT, phone: 765 714 9765, email: hhuanlei@hotmail.com, contacts name: Huang huanlei, Phd, role: PRINCIPAL_INVESTIGATOR, contacts name: Zhao Junfei, Phd, role: PRINCIPAL_INVESTIGATOR, contacts name: He Biaochuan, Phd, role: PRINCIPAL_INVESTIGATOR, contacts name: Zhang Zhaolong, BD, role: PRINCIPAL_INVESTIGATOR, contacts name: Wang Zhenzhong, MD, role: PRINCIPAL_INVESTIGATOR, contacts name: Wang Qiuji, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 23.11667, lon: 113.25, hasResults: False
protocolSection identificationModule nctId: NCT06332521, orgStudyIdInfo id: 23CH296, secondaryIdInfos id: ANSM, type: OTHER, domain: 2024-A00286-41, briefTitle: Infant Crying, a Bioacoustic Prognostic Signal for Neurodevelopment, acronym: BABYCRY_1000, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-20, primaryCompletionDateStruct date: 2029-04-01, completionDateStruct date: 2029-04-01, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Centre Hospitalier Universitaire de Saint Etienne, class: OTHER, descriptionModule briefSummary: Crying is a vital communication signal for the baby. Product of a complex physiological process, it reflects not only the organization and functioning of the cortical central nervous system and the function of sympathetic and parasympathetic autonomic regulation but also the integrity of three entities: the lungs responsible for ventilatory mechanics and respiratory rhythm, the larynx and its vocal cords as a phonatory organ, and the oropharyngeal tract guaranteeing the resonance of the sound emitted by the vocal cords.Crying is usually caused by pain, discomfort, hunger, or separation from parents or other caregivers. Crying carries essential information from birth, the expression of which depends closely on the neuroanatomical and functional brain integrity of the child. On a bioacoustic level, crying consists of sequences of complex acoustic signals produced by the vocal folds and filtered by the vocal tract. The vibration frequency of the vocal cords determines the cry's fundamental frequency f0 (and the harmonic frequencies), which is responsible for its more or less low or high pitch. Other acoustic cues also characterize each baby's cry., conditionsModule conditions: Newborn; Vitality, conditions: Premature Infants, conditions: Infant Development, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 1100, type: ESTIMATED, armsInterventionsModule interventions name: Acoustic signal analysis method, outcomesModule primaryOutcomes measure: Fundamental frequency f0 (Hz), primaryOutcomes measure: Bailey-4 quantitative scale, secondaryOutcomes measure: Percentage voiced frames, secondaryOutcomes measure: Harmonics of f0 (Hz), secondaryOutcomes measure: Median pitch f0 (Hz), secondaryOutcomes measure: Harmonicity (dB), secondaryOutcomes measure: Jitter (Percentage),, secondaryOutcomes measure: Q25 (Percentage), secondaryOutcomes measure: Median Cepstral Peak Prominence (CPP) (dB), eligibilityModule sex: ALL, maximumAge: 4 Days, stdAges: CHILD, contactsLocationsModule locations facility: Chu de Saint-Etienne, status: RECRUITING, city: Saint-Étienne, zip: 42055, country: France, contacts name: Hugues PATURAL, MD-PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.43389, lon: 4.39, hasResults: False
protocolSection identificationModule nctId: NCT06332508, orgStudyIdInfo id: 2022/00406, briefTitle: Pulsed Electromagnetic Fields (PEMFs) - A Highly Selective Breast CAncer Treatment pLatform (PASCAL), statusModule overallStatus: RECRUITING, startDateStruct date: 2022-12-30, primaryCompletionDateStruct date: 2025-12, completionDateStruct date: 2025-12, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: National University Hospital, Singapore, class: OTHER, collaborators name: National University of Singapore, descriptionModule briefSummary: To assess the safety and tolerability of combined PEMFs and anthracycline-based chemotherapy in subjects who are undergoing neoadjuvant chemotherapy for breast cancer treatment., conditionsModule conditions: Breast Cancer, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 36, type: ESTIMATED, armsInterventionsModule interventions name: Pulsed electromagnetic fields (PEMFs), interventions name: Anthracycline-based chemotherapy, outcomesModule primaryOutcomes measure: Incidence of Treatment-Emergent Adverse Events as assessed by CTCAE 5.0, secondaryOutcomes measure: Treatment response as assessed by clinical measurement of tumor size using calipers, eligibilityModule sex: FEMALE, minimumAge: 21 Years, maximumAge: 99 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: National University Hospital, status: RECRUITING, city: Singapore, zip: 119074, country: Singapore, contacts name: Joline Si Jing Lim, role: CONTACT, phone: 69082222, email: joline_sj_lim@nuhs.edu.sg, contacts name: Joline Si Jing Lim, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 1.28967, lon: 103.85007, hasResults: False
protocolSection identificationModule nctId: NCT06332482, orgStudyIdInfo id: M0303023RP, briefTitle: Complete Digital Workflow for Construction of Full Arch Implant Supported Screw Retained Restoration, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2023-03-30, primaryCompletionDateStruct date: 2024-05-20, completionDateStruct date: 2024-09-15, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: Mansoura University, class: OTHER, descriptionModule briefSummary: This study will compare the occlusal accuracy of different techniques for recording maxillomandibular relationships in a Complete digital workflow to construct full arch implant-supported screw-retained restoration., conditionsModule conditions: Prosthesis Durability, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, interventionModelDescription: digital impressions will be made for each patient,3 technique will be used to determine intermaxillary relation. Occlusal prematurties of final prosthesis will compared using occlusense device and all patients will be followed up for one year, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 10, type: ACTUAL, armsInterventionsModule interventions name: Implant supported screw retained prosthesis, outcomesModule primaryOutcomes measure: measurement of occlusal prematurity, primaryOutcomes measure: prosthestic complications, eligibilityModule sex: ALL, minimumAge: 45 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Mansoura University ,Faculty of dentistry, city: Mansoura, zip: P.O.Box:35516, country: Egypt, geoPoint lat: 31.03637, lon: 31.38069, hasResults: False