protocolSection identificationModule nctId: NCT06287528, orgStudyIdInfo id: 23-307, briefTitle: A Study of 19-28z/IL-18 in People With Acute Lymphoblastic Leukemia (ALL), statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-23, primaryCompletionDateStruct date: 2028-02-23, completionDateStruct date: 2028-02-23, studyFirstPostDateStruct date: 2024-03-01, lastUpdatePostDateStruct date: 2024-04-03, sponsorCollaboratorsModule leadSponsor name: Memorial Sloan Kettering Cancer Center, class: OTHER, descriptionModule briefSummary: Participants will have a sample of their white blood cells, called T cells, collected using a procedure called leukapheresis. The collected T cells will be sent to a laboratory to be changed (modified) to become 19-28z/IL-18, the CAR T-cell therapy that participants will receive during the study. Making the participants' study therapy will take about 2-4 weeks., conditionsModule conditions: Philadelphia-Negative ALL, conditions: Philadelphia-Positive ALL, conditions: Relapsed ALL, Adult, conditions: Refractory Acute Lymphoblastic Leukemia, conditions: Refractory Acute Lymphoblastic Leukemia (ALL), conditions: Refractory Acute Lymphoid Leukemia in Relapse, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NON_RANDOMIZED, interventionModel: SEQUENTIAL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 18, type: ESTIMATED, armsInterventionsModule interventions name: 19-28z/IL-18 CAR T cells, outcomesModule primaryOutcomes measure: Toxicity as determined by CTCAE, version 5.0, eligibilityModule sex: ALL, minimumAge: 17 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities), status: RECRUITING, city: Basking Ridge, state: New Jersey, zip: 07920, country: United States, contacts name: Jae Park, MD, role: CONTACT, phone: 646-608-3743, geoPoint lat: 40.70621, lon: -74.54932, locations facility: Memorial Sloan Kettering Monmouth (Limited Protocol Activities), status: RECRUITING, city: Middletown, state: New Jersey, zip: 07748, country: United States, contacts name: Jae Park, MD, role: CONTACT, phone: 646-608-3743, geoPoint lat: 40.39652, lon: -74.09211, locations facility: Memorial Sloan Kettering Bergen (Limited Protocol Activities), status: RECRUITING, city: Montvale, state: New Jersey, zip: 07645, country: United States, contacts name: Jae Park, MD, role: CONTACT, phone: 646-608-3743, geoPoint lat: 41.04676, lon: -74.02292, locations facility: Memorial Sloan Kettering Cancer Suffolk-Commack (Limited Protocol Activities), status: RECRUITING, city: Commack, state: New York, zip: 11725, country: United States, contacts name: Jae Park, MD, role: CONTACT, phone: 646-608-3743, geoPoint lat: 40.84288, lon: -73.29289, locations facility: Memorial Sloan Kettering Westchester (Limited Protocol Activities), status: RECRUITING, city: Harrison, state: New York, zip: 10604, country: United States, contacts name: Jae Park, MD, role: CONTACT, phone: 646-608-3743, geoPoint lat: 40.96899, lon: -73.71263, locations facility: Memorial Sloan Kettering Cancer Center (All Protocol Activities), status: RECRUITING, city: New York, state: New York, zip: 10065, country: United States, contacts name: Jae Park, MD, role: CONTACT, phone: 646-608-3743, geoPoint lat: 40.71427, lon: -74.00597, locations facility: Memorial Sloan Kettering Nassau (Limited Protocol Activities), status: RECRUITING, city: Uniondale, state: New York, zip: 11553, country: United States, contacts name: Jae Park, MD, role: CONTACT, phone: 646-608-3743, geoPoint lat: 40.70038, lon: -73.59291, hasResults: False