protocolSection identificationModule nctId: NCT06363058, orgStudyIdInfo id: 201902166B0, briefTitle: Electrical Stimulation Cycling Training Effects on SCA, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-04-08, primaryCompletionDateStruct date: 2025-07-31, completionDateStruct date: 2025-07-31, studyFirstPostDateStruct date: 2024-04-12, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Chang Gung University, class: OTHER, descriptionModule briefSummary: To focuses on the challenges faced by individuals with spinocerebellar ataxia (SCA), highlighting the major clinical sign of ataxia that affects their stability and ability to perform daily activities, thereby impacting their quality of life. It outlines the concept of neural plasticity, which is the brain's ability to adapt through changes in excitability, and notes that these changes are more enduring in the central nervous system (CNS) than in the peripheral nervous system (PNS). This adaptability, crucial for memory and motor learning, is compromised in SCA patients due to impaired brain areas and pathways. The summary further delves into motor learning, distinguishing between explicit and implicit learning, and points out that SCA patients exhibit deficiencies in procedural learning and cerebellar function. It also introduces the concept of priming as a preparatory mechanism that can enhance the effectiveness of physical therapy by modifying subsequent responses to stimuli. The document suggests that cycling, as an aerobic exercise, could prime the brain for improved blood flow and oxygenation, thereby supporting synaptic plasticity and the release of beneficial neurotrophic factors. Finally, the project aims to deepen the understanding of motor performance and learning mechanisms in SCA patients and apply these insights to clinical rehabilitation strategies., conditionsModule conditions: Spinocerebellar Ataxia (SCA), designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 145, type: ESTIMATED, armsInterventionsModule interventions name: ES Cycling Training, outcomesModule primaryOutcomes measure: Overall Response Time, primaryOutcomes measure: Overall Error Rate, primaryOutcomes measure: Motor Evoked Potentials (MEPs), primaryOutcomes measure: Intracortical Facilitation (ICF), primaryOutcomes measure: Intracortical Inhibition (ICI), primaryOutcomes measure: Total Scale for the Assessment and Rating of Ataxia (SARA) Score, primaryOutcomes measure: Total Berg Balance Scale (BBS) Score, primaryOutcomes measure: Total Time to Complete the Time Up and Go test (TUG test), primaryOutcomes measure: Walking Speed, primaryOutcomes measure: Step Length, primaryOutcomes measure: Step Time, secondaryOutcomes measure: Double Support Time, secondaryOutcomes measure: Single Support Time, secondaryOutcomes measure: Swing Time, secondaryOutcomes measure: Stance Time, secondaryOutcomes measure: Cadence, eligibilityModule sex: ALL, minimumAge: 20 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Chang Gung University, status: RECRUITING, city: Taoyuan, zip: 333, country: Taiwan, contacts name: Ya-Ju Chang, PhD, role: CONTACT, phone: 88632118800, phoneExt: 5515, email: yjchang@mail.cgu.edu.tw, geoPoint lat: 24.95233, lon: 121.20193, hasResults: False