hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06354530, orgStudyIdInfo id: 2023 (315), briefTitle: A Study of Neoadjuvant Therapy for the Treatment of Patients With Locally Advanced Esophageal Squamous Cell Carcinoma, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-08, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Army Medical Center of PLA, class: OTHER_GOV, descriptionModule briefSummary: The goal of this interventional study is to compare the safety and efficacy of neoadjuvant immunotherapy plus chemotherapy and anlotinib versus immunotherapy combined with concurrent chemoradiotherapy in the treatment of locally advanced esophageal squamous cell carcinoma. The main question it aims to answer is: To evaluate the safety and efficacy of neoadjuvant immunotherapy plus chemotherapy and anlotinib versus immunotherapy combined with concurrent chemoradiotherapy in patients with locally advanced esophageal squamous cell carcinoma and to explore the optimal preoperative neoadjuvant treatment regimen for esophageal squamous cell carcinoma., conditionsModule conditions: Neoadjuvant Therapy, conditions: Esophageal Squamous Cell Carcinoma, designModule studyType: INTERVENTIONAL, phases: PHASE2, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 266, type: ESTIMATED, armsInterventionsModule interventions name: anlotinib, interventions name: Thoracic radiotherapy, outcomesModule primaryOutcomes measure: Pathological complete response (pCR), Major pathological response (MPR), primaryOutcomes measure: Major pathological response (MPR), secondaryOutcomes measure: Objective response rate (ORR), secondaryOutcomes measure: 3-year disease free survival, secondaryOutcomes measure: R0 excision rate, secondaryOutcomes measure: 3-year overall survival, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Army Medical Center of PLA, status: RECRUITING, city: Chongqing, state: None Selected, country: China, contacts name: Mengxia Li, role: CONTACT, phone: +86-18580408265, email: mengxia.li@outlook.com, contacts name: Xiao Yang, role: CONTACT, phone: +86-19923257675, email: yangxiao625@outlook.com, geoPoint lat: 29.56278, lon: 106.55278, hasResults: False
protocolSection identificationModule nctId: NCT06354517, orgStudyIdInfo id: YIU-M-CI-003, briefTitle: The Impact of the SENSE Program on NICU, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2025-05-30, completionDateStruct date: 2025-05-30, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Yuksek Ihtisas University, class: OTHER, descriptionModule briefSummary: The SENSE program will be applied to babies receiving treatment in the neonatal intensive care unit and the effect of the application on the baby and parents will be examined., conditionsModule conditions: Pre-Term, conditions: Individualized Developmental Care, conditions: Sensory Experiences, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: SENSE group, outcomesModule primaryOutcomes measure: Hammersmıth Neonatal Neurologıcal Examınatıon, primaryOutcomes measure: Parental Stress Scale: Neonatal Intensive Care Unit, primaryOutcomes measure: State-trait Anxiety Inventory, primaryOutcomes measure: Edinburgh Postnatal Depression Scale, eligibilityModule sex: ALL, minimumAge: 24 Weeks, maximumAge: 42 Weeks, stdAges: CHILD, contactsLocationsModule locations facility: Yuksek Ihtisas University, city: Ankara, country: Turkey, geoPoint lat: 39.91987, lon: 32.85427, hasResults: False
protocolSection identificationModule nctId: NCT06354504, orgStudyIdInfo id: 20.02.2019/177, briefTitle: Bactericidal Permeability Protein Inhibitor and Interleukin-1beta Levels After Non-surgical Periodontal Treatment, statusModule overallStatus: COMPLETED, startDateStruct date: 2019-11-19, primaryCompletionDateStruct date: 2020-09-20, completionDateStruct date: 2020-09-20, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Akdeniz University, class: OTHER, descriptionModule briefSummary: The aim of this study was to examine the relationship between healing response after non-surgical periodontal treatment and baseline gingival crevicular fluid (GCF) levels of bactericidal/permeability-increasing protein (BPI) and interleukin-1beta (IL-1ß)., conditionsModule conditions: Periodontitis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 30, type: ACTUAL, armsInterventionsModule interventions name: Non-surgical periodontal treatment, outcomesModule primaryOutcomes measure: Gingival crevicular fluid Bactericidal/permeability-increasing proteins levels, secondaryOutcomes measure: Gingival crevicular fluid interleukin-1Beta levels, eligibilityModule sex: ALL, minimumAge: 22 Years, maximumAge: 64 Years, stdAges: ADULT, contactsLocationsModule locations facility: Akdeniz Üniversity, city: Antalya, zip: 07070, country: Turkey, geoPoint lat: 36.90812, lon: 30.69556, locations facility: Akdeniz Üniversitesi Diş Hekimliği Fakültesi, city: Antalya, country: Turkey, geoPoint lat: 36.90812, lon: 30.69556, hasResults: False
protocolSection identificationModule nctId: NCT06354491, orgStudyIdInfo id: 2023-1494, briefTitle: An Imaging-based Quantitative Biomarker Assay for NAFLD in Children, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2026-04-01, completionDateStruct date: 2027-04-01, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: University of Wisconsin, Madison, class: OTHER, descriptionModule briefSummary: This study will validate recently developed Magnetic Resonance Imaging (MRI) and Ultrasound (US) based methods for liver fat quantification in children with obesity and healthy range of body mass index (BMI)., conditionsModule conditions: NAFLD, conditions: NASH, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 24, type: ESTIMATED, armsInterventionsModule interventions name: Magnetic Resonance Imaging (MRI), interventions name: Ultrasound (US), outcomesModule primaryOutcomes measure: MRI, primaryOutcomes measure: Quantitative US, eligibilityModule sex: ALL, minimumAge: 10 Years, maximumAge: 14 Years, stdAges: CHILD, contactsLocationsModule locations facility: University of Wisconsin, Madison, status: RECRUITING, city: Madison, state: Wisconsin, zip: 53705, country: United States, contacts name: Gemma Gliori, MS, role: CONTACT, phone: 608-262-7269, email: ggliori@uwhealth.org, contacts name: Suzanne Hanson, BS, role: CONTACT, phone: 608-262-7269, email: shanson@uwhealth.org, geoPoint lat: 43.07305, lon: -89.40123, hasResults: False
protocolSection identificationModule nctId: NCT06354465, orgStudyIdInfo id: IRB1967355, secondaryIdInfos id: K23DA055695, type: NIH, link: https://reporter.nih.gov/quickSearch/K23DA055695, briefTitle: Injectable Extended-Release Buprenorphine (XR-B) in a Correctional Setting: Qualitative Interviews, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-07-01, primaryCompletionDateStruct date: 2024-07-01, completionDateStruct date: 2024-07-01, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Lifespan, class: OTHER, collaborators name: National Institute on Drug Abuse (NIDA), descriptionModule briefSummary: This qualitative study investigates the potential benefits and challenges of using a once-a-month injectable medication, known as extended-release buprenorphine (XR-B), to treat individuals with opioid use disorder (OUD) within a correctional setting. The research aims to understand if XR-B can be a feasible and effective alternative to the standard daily treatment and to identify which groups within the prison population may benefit the most from this treatment. In-depth interviews are conducted with incarcerated individuals and relevant stakeholders., conditionsModule conditions: Opioid Use Disorder, conditions: Criminal Justice, conditions: Treatment Adherence and Compliance, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 25, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Qualitative Transcripts, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Rhode Island Department of Corrections, status: RECRUITING, city: Cranston, state: Rhode Island, zip: 02920, country: United States, contacts name: Jessica Migliaccio, role: CONTACT, phone: 401-462-3921, email: doc.planning@doc.ri.gov, geoPoint lat: 41.77982, lon: -71.43728, documentSection largeDocumentModule largeDocs typeAbbrev: Prot, hasProtocol: True, hasSap: False, hasIcf: False, label: Study Protocol, date: 2023-10-09, uploadDate: 2024-03-31T17:37, filename: Prot_000.pdf, size: 125769, largeDocs typeAbbrev: ICF, hasProtocol: False, hasSap: False, hasIcf: True, label: Informed Consent Form, date: 2023-01-07, uploadDate: 2024-04-04T09:46, filename: ICF_001.pdf, size: 488632, hasResults: False
protocolSection identificationModule nctId: NCT06354452, orgStudyIdInfo id: HGG2024_01, briefTitle: Effect of Statin Therapy on Sepsis-related Mortality in Intensive Care Unit Patients, acronym: HGG_UCI1, statusModule overallStatus: COMPLETED, startDateStruct date: 2018-01-01, primaryCompletionDateStruct date: 2019-12-31, completionDateStruct date: 2020-01-31, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Hospital de Granollers, class: OTHER, collaborators name: Department of Health, Generalitat de Catalunya, descriptionModule briefSummary: The average age of patients with sepsis has increased in recent years in parallel with the incidence of sepsis. Many of these patients are frail and require various medications for the treatment of their chronic diseases. Common treatments, including e.g. sarcopenic drugs (statins, sulphonylureas, methyglinides), antioxidants that prevent sarcopenia (allopurinol) or immunoregulators (corticosteroids) may influence the survival and functional prognosis of these patients. Knowing which drugs influence sepsis survival and to what degree patients who survive sepsis have functional deterioration and increased comorbidity and which modifiable factors limit this may be essential., conditionsModule conditions: Sepsis, conditions: Septic Shock, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: OTHER, enrollmentInfo count: 59578, type: ACTUAL, armsInterventionsModule interventions name: Person-level linkage of the database looking for relationship with sepsis survival and previous intake of certain drug families and previous dependence on health services., outcomesModule primaryOutcomes measure: Death due to sepsis, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hospital General de Granollers, city: Granollers, state: Barcelona, zip: 08402, country: Spain, geoPoint lat: 41.60797, lon: 2.28773, hasResults: False
protocolSection identificationModule nctId: NCT06354439, orgStudyIdInfo id: 77015224.6.1001.5327, briefTitle: Use of Letrozole for Ectopic Pregnancy, acronym: EcZOL, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-27, primaryCompletionDateStruct date: 2026-12-31, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Hospital de Clinicas de Porto Alegre, class: OTHER, descriptionModule briefSummary: A randomized clinical trial using oral letrozole 10mg/day for 7 days, for treating early cases of ectopic pregnancy, compared to intramuscular methotrexate, conditionsModule conditions: Ectopic Pregnancy, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized clinical trial, primaryPurpose: TREATMENT, maskingInfo masking: NONE, maskingDescription: Due to the nature of the outcome and the interventions, blinding was not considered an issue., enrollmentInfo count: 130, type: ESTIMATED, armsInterventionsModule interventions name: Letrozole tablets, interventions name: Methotrexate Sodium, outcomesModule primaryOutcomes measure: levels of beta fraction of human chorionic gonadotropin (beta-hCG), eligibilityModule sex: FEMALE, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hospital de Clínicas de Porto Alegre, status: RECRUITING, city: Porto Alegre, state: RS, zip: 90035-903, country: Brazil, contacts name: RICARDO F SAVARIS, MD,PHD, role: CONTACT, phone: 55 51 33598117, email: rsavaris@hcpa.edu.br, contacts name: Michele S Savaris, BBA, role: CONTACT, phone: 555133598624, email: msavaris@hcpa.edu.br, geoPoint lat: -30.03306, lon: -51.23, hasResults: False
protocolSection identificationModule nctId: NCT06354426, orgStudyIdInfo id: BVT2022/01, briefTitle: Short-term Mortality Prediction by the SOFA Score in Acute Decompensated Heart Failure, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-07-01, primaryCompletionDateStruct date: 2023-08-31, completionDateStruct date: 2023-08-31, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Hanoi Heart Hospital, class: OTHER, descriptionModule briefSummary: Data on the use of sequential organ failure assessment (SOFA) in patients with cardiovascular disease are increasing. Several studies demonstrated that the SOFA score can identify short-term mortality in patients with acute decompensated heart failure (ADHF). This study was conducted to determine the prognostic value of the admission SOFA score in patients hospitalised for ADHF and to assess its ability in predicting the 30-day readmission rate., conditionsModule conditions: Acute Decompensated Heart Failure, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 216, type: ACTUAL, outcomesModule primaryOutcomes measure: Mortality, secondaryOutcomes measure: Re-admission rate, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hanoi Heart Hospital, city: Hanoi, state: Hoan Kiem, zip: 110000, country: Vietnam, geoPoint lat: 21.0245, lon: 105.84117, hasResults: False
protocolSection identificationModule nctId: NCT06354413, orgStudyIdInfo id: 2023-2261, briefTitle: Outcomes of Concomitant Bypass Surgery in Septal Myectomy, statusModule overallStatus: COMPLETED, startDateStruct date: 2009-01, primaryCompletionDateStruct date: 2020-12, completionDateStruct date: 2023-12, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Chinese Academy of Medical Sciences, Fuwai Hospital, class: OTHER, descriptionModule briefSummary: To investigate clinical characteristics and survival outcomes of patients with obstructive hypertrophic cardiomyopathy who underwent concomitant coronary artery bypass grafting during septal myectomy., conditionsModule conditions: Hypertrophic Cardiomyopathy, conditions: Coronary Artery Disease, conditions: Myocardial Bridging, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 320, type: ACTUAL, armsInterventionsModule interventions name: CABG during myectomy, outcomesModule primaryOutcomes measure: all-cause mortality, secondaryOutcomes measure: cardiac-related deaths and readmission, eligibilityModule sex: ALL, minimumAge: 8 Years, maximumAge: 90 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06354400, orgStudyIdInfo id: 2022/001-002, briefTitle: Core Stabilization Training on Chest Expansion, Functional Capacity, Trunk Muscle Endurance in Hearing-Impaired Children, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-30, primaryCompletionDateStruct date: 2024-05-30, completionDateStruct date: 2024-06-30, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Bezmialem Vakif University, class: OTHER, collaborators name: Nuh Naci Yazgan University, descriptionModule briefSummary: Children's motor skills and physical performance increase with age due to the development of neuromuscular and cardiorespiratory systems. Sensory impairment seen in children with hearing loss can cause balance and coordination disorders, as well as decreased muscle strength and respiratory functions.Anatomically, core stabilization is provided by the diaphragm, abdominal, hip, pelvic floor, and gluteal muscles. Training for these muscles is intended to improve strength, endurance, and neuromuscular control. This training can help to improve the control of intra-abdominal pressure, intersegmental control of the spine, and muscular control of trunk movement. It also helps in strengthening the respiratory muscles, especially the main inspiratory muscle, the diaphragm. In this study, the effects of core stabilization training on children with hearing impairments' thoracic mobility, functional ability, and trunk muscle endurance will be examined., conditionsModule conditions: Core Stabilization, conditions: Respiration, conditions: Functional Capacity, conditions: Endurance, conditions: Hearing Impaired Children, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 26, type: ESTIMATED, armsInterventionsModule interventions name: Core stabilization training, outcomesModule primaryOutcomes measure: Chest expansion, secondaryOutcomes measure: Functional capacity, secondaryOutcomes measure: Trunk muscle endurance, eligibilityModule sex: ALL, minimumAge: 10 Years, maximumAge: 15 Years, stdAges: CHILD, contactsLocationsModule locations facility: Nuh Naci Yazgan University, status: RECRUITING, city: Kayseri, country: Turkey, contacts name: Busra Kepenek-Varol, PhD, PT, role: CONTACT, phone: +905449106628, email: bkvarol@nny.edu.tr, contacts name: Busra Kepenek Varol, PhD, PT, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.73222, lon: 35.48528, hasResults: False
protocolSection identificationModule nctId: NCT06354387, orgStudyIdInfo id: CMUH110-REC3-246, briefTitle: Alectinib in Combination With Nivolumab in the Treatment of Recurrent or Refractory HCC Patients Guided With Serum RNase1 and Tumor Expression of PD-L1, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-02-16, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2025-06-01, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: China Medical University Hospital, class: OTHER, descriptionModule briefSummary: Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death and the second most deadly malignancy in Taiwan. Despite decades' intensive studies, surgery and local-regional chemo-embolization, radio-frequency ablation or radiation therapy remain the mainstay of HCC treatments., conditionsModule conditions: Hepatocellular Carcinoma, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 8, type: ESTIMATED, armsInterventionsModule interventions name: Alectinib (Alecensa), Nivolumab (Opdivo), outcomesModule primaryOutcomes measure: Objective response rate(ORR), secondaryOutcomes measure: PFS, otherOutcomes measure: TTP, otherOutcomes measure: DOR, otherOutcomes measure: DCR, otherOutcomes measure: OS, eligibilityModule sex: ALL, minimumAge: 20 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: CMUH, status: RECRUITING, city: Taichung, country: Taiwan, contacts name: Chang-Fang Chiu, PhD, role: CONTACT, phone: 8864-22052121, email: 005686@tool.caaumed.org.tw, geoPoint lat: 24.1469, lon: 120.6839, hasResults: False
protocolSection identificationModule nctId: NCT06354374, orgStudyIdInfo id: 24-026, briefTitle: Soft Tissue Volume, Dimensions and Tomographic Alveolar Ridge Classification System for Dental Implant Treatment., statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-22, primaryCompletionDateStruct date: 2024-07, completionDateStruct date: 2024-12, studyFirstPostDateStruct date: 2024-04-09, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Ain Shams University, class: OTHER, collaborators name: British University In Egypt, descriptionModule briefSummary: Despite the importance of soft tissue dimensions for periodontal, restorative, implant, and orthodontic treatment, the current classifications of tomographic alveolar ridge topography lack the soft tissue component(Tolstunov, 2014). Therefore, the present study will be to evaluate the relationship between soft tissue volume and the dimensions \& tomographic alveolar ridge classes as well as to incorporate the soft tissue volumetric evaluation in the classification system., conditionsModule conditions: Soft Tissue Volume, designModule studyType: OBSERVATIONAL, designInfo observationalModel: ECOLOGIC_OR_COMMUNITY, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 350, type: ESTIMATED, armsInterventionsModule interventions name: volume survey, outcomesModule primaryOutcomes measure: the relationship between soft tissue volume & tomographic alveolar ridge classes, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Ahmed Hamdy, status: RECRUITING, city: Al Shorouk City, state: Cairo, zip: 11837, country: Egypt, contacts name: Ahmed Hamdy, role: CONTACT, phone: +201061112512, email: ahmed.esmaail@bue.edu.eg, hasResults: False