protocolSection identificationModule nctId: NCT06345417, orgStudyIdInfo id: O-PBM1, briefTitle: Outcomes of Patient Blood Management in Severely Anemic Patients, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2025-04-01, completionDateStruct date: 2025-05-01, studyFirstPostDateStruct date: 2024-04-03, lastUpdatePostDateStruct date: 2024-04-03, sponsorCollaboratorsModule leadSponsor name: Helios Klinik Gotha/Ohrdruf, class: OTHER, collaborators name: Helios Klinikum Erfurt, descriptionModule briefSummary: The goal of this observational cohort study is to compare patients with very low red blood counts who receive different therapy. Its main question\[s\] it aims to answer are:* Which group of patients dies more frequent: Patients who receive patient blood management only, patients who receive patient blood management and transfusions or patients who receive only transfusions?* Among these groups: which group of patients has more complications during hospital stay? Patients will either receive patient blood management, which is the management of anemia, bleeding and coagulation problems, will receive transfusions, that is, blood from other people, or a mix of both., conditionsModule conditions: Severe Anemia, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 20000, type: ESTIMATED, armsInterventionsModule interventions name: Patient Blood Management (PBM), interventions name: Allogeneic transfusion, outcomesModule primaryOutcomes measure: Number of dead participants at the end of hospitalization (inhospital mortality), secondaryOutcomes measure: Number of participants with surgical wound complications, secondaryOutcomes measure: Number of participants with a documented acute myocardial infarction, secondaryOutcomes measure: Number of participants suffering renal injury, secondaryOutcomes measure: Number of days spent in hospital (Length of stay in hospital), secondaryOutcomes measure: Number of participants readmitted to the studied hospital, secondaryOutcomes measure: Number of participants with a documented transfusion reaction, secondaryOutcomes measure: Number of participants receiving an allogeneic transfusion, secondaryOutcomes measure: Number of participants treated in an intensive care ward, secondaryOutcomes measure: Number of participants with documented respiratory complications, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Helios Klinikum, city: Erfurt, state: Thuringia, country: Germany, contacts name: Achim Spenner, role: CONTACT, phone: +49-361-7810, email: Achim.Spenner@helios-gesundheit.de, geoPoint lat: 50.9787, lon: 11.03283, locations facility: Helios Klinikum, city: Gotha, state: Thuringia, zip: 99867, country: Germany, contacts name: Petra See, role: CONTACT, phone: +49-3621-220 0, email: petra.seeber@helios-gesundheit.de, contacts name: Kai D, role: CONTACT, phone: +49-3621-220, phoneExt: 5058, email: Kai-uwe.doebel@helios-gesundheit.de, geoPoint lat: 50.94823, lon: 10.70193, hasResults: False