protocolSection identificationModule nctId: NCT06371261, orgStudyIdInfo id: 2023/CHU/07, briefTitle: Pathogenicity of Species of the Achromobacter Genus in Patients From Reunion Island With Cystic Fibrosis, acronym: ACHROMO-MUCO, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-29, primaryCompletionDateStruct date: 2027-03, completionDateStruct date: 2027-03, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Centre Hospitalier Universitaire de la Réunion, class: OTHER, descriptionModule briefSummary: The pathogenicity of Achromobacter bacteria is not yet well established, but studies show a decline in respiratory function and an increase in mortality associated with chronic colonisation, making it possible to classify the Achromobacter genus as an emerging pathogen in cystic fibrosis. It is possible that certain species or clones are more virulent or resistant, requiring the adaptation of measures to prevent cross-transmission in the centres concerned.However, until now, the identification of Achromobacter species has involved the use of molecular biology techniques that are not routinely applicable in diagnostic laboratories, limiting studies and the collection of epidemiological data. Recently, a database using MALDI-TOF mass spectrometry has been built for rapid and accurate species identification.In view of the local epidemiology and the current lack of data, it would be necessary and interesting to use this tool to study a cohort of cystic fibrosis patients in Réunion island (North and South sites) to see whether one species has a greater clinical impact than another (pathogenicity), and/or is more responsible for chronic colonisation., conditionsModule conditions: Cystic Fibrosis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 35, type: ESTIMATED, armsInterventionsModule interventions name: Biological analyses, outcomesModule primaryOutcomes measure: Frequency of pulmonary exacerbations according to the species of the Achromobacter genus colonising/infecting cystic fibrosis patients., secondaryOutcomes measure: Frequency of pulmonary exacerbations as a function of Achromobacter spp. colonisation status., secondaryOutcomes measure: Emergence or existing presence of clones within the species of the genus Achromobacter circulating among cystic fibrosis patients in Réunion, using genomic analyses., secondaryOutcomes measure: Presence of virulence factors in these strains using genomic analyses, secondaryOutcomes measure: Search for genes responsible for antibiotic resistance by genomic analysis of these strains, secondaryOutcomes measure: To describe the epidemiology of Achromobacter spp. in cystic fibrosis patients in Réunion, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: CHU la Réunion North, status: RECRUITING, city: Saint-Denis, country: Réunion, contacts name: VERHILLE Juliette, MD, role: CONTACT, email: Juliette.verhille@chu-reunion.fr, contacts name: Juliette VERHILLE, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -20.88231, lon: 55.4504, locations facility: CHU la Réunion South, status: RECRUITING, city: Saint-Pierre, country: Réunion, contacts name: PERISSON Caroline, MD, role: CONTACT, email: Caroline.perisson@chu-reunion.fr, contacts name: Caroline PERISSON, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: -21.3393, lon: 55.47811, hasResults: False