hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06380023, orgStudyIdInfo id: 2022.354, briefTitle: An Investigation Into the Dispersion Pattern During Coughing and Open Nasopharyngeal Suction Using Various Barrier Devices, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-09-01, primaryCompletionDateStruct date: 2024-03-03, completionDateStruct date: 2024-03-03, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: North District Hospital, class: OTHER, collaborators name: The Hong Kong Polytechnic University, descriptionModule briefSummary: The aim of the study is to examine the air dispersion pattern and the environmental influence of open airway suction in general ward setting. Secondly, the study is aimed at identifying a simple \& practical enclosure device in general ward. Suction will be performed in manikin in supine lying.Nasopharyngeal suction will be performed by physiotherapist with working experience more than 1 years. Besides, surgical mask \& enclosure tent will be adopted as the enclosure barrier device in this study.Research Question1. To assess the extent of the environmental contamination during coughing and simulated airway suction2. To measure the air particle count during coughing and simulated open airway suction.3. To evaluate how effective the enclosure barrier in reducing the air particle dispersion during open airway suction., conditionsModule conditions: Airway Aspiration, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 13, type: ACTUAL, armsInterventionsModule interventions name: Enclosure barrier, outcomesModule primaryOutcomes measure: Air particle count, secondaryOutcomes measure: A fluorescent Dye, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: North District Hospital, city: Hong Kong, zip: 000000, country: Hong Kong, geoPoint lat: 22.27832, lon: 114.17469, hasResults: False
protocolSection identificationModule nctId: NCT06380010, orgStudyIdInfo id: IASO HOSPITAL (ATHENS-GREECE), briefTitle: Mediterranean Diet Intervention in Adolescents With Polycystic Ovary Syndrome, statusModule overallStatus: COMPLETED, startDateStruct date: 2019-12-01, primaryCompletionDateStruct date: 2020-03-31, completionDateStruct date: 2020-06-30, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Iaso Maternity Hospital, Athens, Greece, class: OTHER, collaborators name: Harokopio University, collaborators name: University of Peloponnese, descriptionModule briefSummary: The aim of the present randomized controlled study was to examine wether a clinical decision support stystem would increase the adherence to the Mediterranean diet (MD) of adolescent girls, aged 15-17 years, diagnosed with polycystic ovary syndrome. The intervention lasted for 3 months and in total, 40 girls were randomly assigned to either the MD group (n=20) or a Control group receiving general nutritional advice (n=20). Anthropometry, nutritional intake, psychological well-being, and blood markers were analyzed at the begninning and the end of the trial., conditionsModule conditions: Polycystic Ovary Syndrome, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Recruitment involved adolescents with polycystic ovary syndrome. Participants, who expressed their willingness to take part, attended personal meetings with the appointed dieticians who provided comprehensive explanations on the objectives, methods, and the potential benefits/risks of the study. A leaflet with related information was provided to all patients. Every eligible volunteer, and their guardian, signed a written informed consent and then kept a hard copy of the signed document. All eligible females were recruited in 12/2019 and were randomly allocated in groups of one to either the Control group (CG) or the Intervention group (IG). The IG received a personalized Mediterranean dietary plan, delivered through a clinical decision support system, while the CG received general dietary advice. Every participant had two individual sessions with the assigned dietician, at the beginning and at the trial endpoint, which involved anthropometry, dietary assessment, and blood withdrawal., primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: Treatment allocation was not revealed to the appointed statistician until the end of the study and release of the final outcomes., whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ACTUAL, armsInterventionsModule interventions name: Mediterranean diet group, outcomesModule primaryOutcomes measure: Adherance to the Mediterranean diet, secondaryOutcomes measure: Improvement of psychological well-being, eligibilityModule sex: FEMALE, minimumAge: 15 Years, maximumAge: 17 Years, stdAges: CHILD, contactsLocationsModule locations facility: IASO Hospital, city: Athens, zip: 15123, country: Greece, geoPoint lat: 37.97945, lon: 23.71622, hasResults: False
protocolSection identificationModule nctId: NCT06379984, orgStudyIdInfo id: 855013, briefTitle: Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use, acronym: ROLDI, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-24, sponsorCollaboratorsModule leadSponsor name: University of Pennsylvania, class: OTHER, collaborators name: National Institute on Drug Abuse (NIDA), descriptionModule briefSummary: The goal of this clinical trial is to learn if buprenorphine can be started for opioid use disorder with fentanyl use without requiring or precipitating opioid withdrawal. To be eligible, participants must have moderate or severe opioid use disorder and must have fentanyl detected on a urine drug test.Participants will be admitted to a monitored research unit for the trial. They will be randomized to start buprenorphine with either standard initiation or with a new approach called rapid outpatient low-dose initiation (ROLDI).For standard initiation, participants will be instructed to arrive to the unit with at least 8 hours since last fentanyl use. Once they have at least moderately severe opioid withdrawal (Clinical Opiate Withdrawal Scale \[COWS\] 11 or higher), participants will receive 2 mg, 2 mg, 4 mg, and then 8 mg sublingual buprenorphine, with doses every 2 hours. They will then continue 8-12 mg twice daily. This is the current standard of care.For ROLDI, participants will not be required to have a period abstinence, they will have no or minimal withdrawal (COWS 4 or less) when starting buprenorphine, and participants will take 0.5 mg, 0.5 mg, 1 mg, 1 mg, 1 mg, and then 4 mg sublingual buprenorphine with dosing every two hours. They will then continue 8-12 mg twice daily.The main aim of this clinical trial is to assess whether ROLDI is safe, feasible, acceptable to patients, and worthwhile to study in a larger trial. The secondary aim is to describe fentanyl and norfentanyl pharmacokinetics (that is to say, fentanyl and norfentanyl concentration in blood and urine) during early abstinence to understand why some people using fentanyl develop precipitated withdrawal with standard initiation., conditionsModule conditions: Opioid Use Disorder, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Buprenorphine, outcomesModule primaryOutcomes measure: Successful initiation of buprenorphine maintenance, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06379971, orgStudyIdInfo id: 23-2327, briefTitle: Maternal Choline Supplementation and Cannabis Use During Pregnancy: Impact on Early Brain Development, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05, primaryCompletionDateStruct date: 2029-04, completionDateStruct date: 2029-04, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: University of Colorado, Denver, class: OTHER, descriptionModule briefSummary: The goal of this study is to determine if providing a nutritional supplement, phosphatidylcholine, to pregnant women who have used cannabis products during the current pregnancy improves the offspring's brain-related development during the first 18 months. Participating pregnant women will receive either phosphatidylcholine or a placebo from approximately 16 weeks gestation through birth. The primary outcomes are the child's brain responses to sound at 4 weeks corrected age, and infant behaviors at 3 months and 18 months corrected age as reported by the primary caregiver. Secondary outcomes include motor, socio-emotional, language and cognitive development., conditionsModule conditions: Child Development, conditions: Cannabis Use, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Phosphatidylcholine or placebo, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 150, type: ESTIMATED, armsInterventionsModule interventions name: Placebo, interventions name: Choline, outcomesModule primaryOutcomes measure: Infant Behavior Questionnaire-Revised (IBQ-R) Orienting/Regulation Index, primaryOutcomes measure: Auditory Sensory Gating (P50), primaryOutcomes measure: Child Behavior Checklist (CBCL) 1 1/2-5, secondaryOutcomes measure: Maternal Plasma Choline Levels, secondaryOutcomes measure: Bayley Scales of Infant and Toddler Development, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: UC Health, city: Aurora, state: Colorado, zip: 80045, country: United States, contacts name: Sharon Hunter, PhD, role: CONTACT, phone: 303-724-6246, email: sharon.hunter@cuanschutz.edu, geoPoint lat: 39.72943, lon: -104.83192, hasResults: False
protocolSection identificationModule nctId: NCT06379958, orgStudyIdInfo id: IST-05, briefTitle: Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-12, primaryCompletionDateStruct date: 2024-05-31, completionDateStruct date: 2024-09-30, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Modern Biosciences Ltd, class: INDUSTRY, descriptionModule briefSummary: A DDI study consisting of 3 parts conducted as an open label, fixed sequence study in healthy adult subjects., conditionsModule conditions: Pharmacokinetics, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 36, type: ESTIMATED, armsInterventionsModule interventions name: leramistat 40mg, interventions name: Itraconazole 200 mg, interventions name: Phenytoin 100 Mg Oral Capsule, interventions name: Simvastatin 40mg, outcomesModule primaryOutcomes measure: leramistat: Area under the curve - AUC0 t, primaryOutcomes measure: leramistat: Area under the curve - AUC0 24, primaryOutcomes measure: leramistat: Area under the curve - AUC0 inf, primaryOutcomes measure: leramistat: Maximum observed concentration - Cmax, primaryOutcomes measure: leramistat: Time of the maximum observed concentration - Tmax, primaryOutcomes measure: leramistat:Elimination rate constant -Kel, primaryOutcomes measure: leramistat: Half life - t½, primaryOutcomes measure: leramistat: Plasma Clearance -CL/F, primaryOutcomes measure: leramistat: Volume of distribution - Vz/F, secondaryOutcomes measure: Incidence of adverse event., eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: Celerion, city: Belfast, country: United Kingdom, contacts name: Phase 1 Unit, role: CONTACT, contacts name: Nadine Abdullah, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 54.59682, lon: -5.92541, hasResults: False
protocolSection identificationModule nctId: NCT06379932, orgStudyIdInfo id: APHP240433, briefTitle: Pain and Muscle Biopsy, acronym: BIODOMU, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-07-01, primaryCompletionDateStruct date: 2024-12-01, completionDateStruct date: 2024-12-01, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Assistance Publique - Hôpitaux de Paris, class: OTHER, descriptionModule briefSummary: Few studies have been conducted on pain assessment during and after open muscle biopsy. Furthermore, no clinical factors likely to influence pain perception during and after open muscle biopsy have been evaluated in previous studies.The proposed observational study aims to study pain perception in subjects over the aged of 18 years old who underwent an open muscle biopsy for a suspected myopathic disorder. Describing the main characteristics of pain during and after open muscle biopsy using a questionnaire will not only clarify this aspect, which is little studied in the literature, but will also provide information for improving analgesic management of the procedure.Studying the prognostic aspects of pain perception will give healthcare professionals an idea of which patients are at risk of suffering greater adverse effects from the procedure, so that they can be offered a personalised service in the future., conditionsModule conditions: Neuromuscular Diseases, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Surveys completion, outcomesModule primaryOutcomes measure: To describe the characteristics and intensity of pain during and after open muscle biopsy on the basis of a questionnaire including NRS scale., secondaryOutcomes measure: To identify prognostic factors that may influence pain perception and to gather opinions to improve quality service, secondaryOutcomes measure: Gather patient feedback on procedures, facilities and reception to improve our service to patients., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06379919, orgStudyIdInfo id: C Acnes in TSA, briefTitle: Wound Irrigation Comparative Effectiveness Study, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-20, primaryCompletionDateStruct date: 2025-05-31, completionDateStruct date: 2027-05-31, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Orthopaedic Education and Research Institute (dba Hoag Orthopedics), class: OTHER, collaborators name: Irrimax Corporation, descriptionModule briefSummary: The primary objective of this study is to compare the presence of C acnes in bacteriologic cultures taken from participant samples of subcutaneous and deep tissue prior to deep surgical irrigation using either Normal Saline Irrigation (Group 1) or Irrisept Irrigation (Group 2). Secondary objectives are evaluation of patient reported outcome measures and range of motion in relation to C acnes presence among subjects in the two groups., conditionsModule conditions: Cutibacterium Acnes Contamination, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Participants are assigned at the beginning of the study to treatment arm involving 1 of 2 types of irrigation treatment for their surgery. They continue in that arm through the length of the study and complete the same study procedures, as well as same standard of care., primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: Participants and Microbiology lab assessing cultures are blinded to the assigned irrigation treatment arm throughout the length of the study., whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 126, type: ESTIMATED, armsInterventionsModule interventions name: Irrisept Irrigation, interventions name: Saline Irrigation Solution Delivery, outcomesModule primaryOutcomes measure: C Acnes Presence, secondaryOutcomes measure: American Shoulder and Elbow Surgeons Patient Reported Outcome Measure, secondaryOutcomes measure: Shoulder Range of Motion (ROM), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hoag Orthopedics, status: RECRUITING, city: Orange, state: California, zip: 92868, country: United States, contacts name: Edward Quilligan, BS, role: CONTACT, phone: 949-526-1570, email: Edward.quilligan@hoagorthopedics.org, contacts name: Kalyn Smith, BS, role: CONTACT, phone: (949) 526-1570, email: kalyn.smith@hoagorthopedics.org, geoPoint lat: 33.78779, lon: -117.85311, hasResults: False
protocolSection identificationModule nctId: NCT06379906, orgStudyIdInfo id: DMD, UE and Balance, briefTitle: Upper Extremity Muscle Strength, Balance and Functional Skills in DMD, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-11-10, primaryCompletionDateStruct date: 2023-12-10, completionDateStruct date: 2024-03-10, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: Halic University, class: OTHER, collaborators name: Biruni University, collaborators name: Istanbul University, descriptionModule briefSummary: This study aims to examine the relationship between upper extremity muscle strength, balance and functional skills of children with DMD., conditionsModule conditions: Duchenne Muscular Dystrophy, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: OTHER, enrollmentInfo count: 32, type: ACTUAL, armsInterventionsModule interventions name: Assessment, outcomesModule primaryOutcomes measure: Upper Extremity Muscle Strength Measurements, primaryOutcomes measure: Trunk Control Measurement Scale, primaryOutcomes measure: Functional Reach Test, primaryOutcomes measure: Timed Up & Go Test, secondaryOutcomes measure: Pediatric Evaluation of Disability Inventory, eligibilityModule sex: MALE, minimumAge: 5 Years, maximumAge: 12 Years, stdAges: CHILD, contactsLocationsModule locations facility: Haliç University, city: Istanbul, state: Eyüpsultan, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06379867, orgStudyIdInfo id: HSK3486-112, briefTitle: A Study to Evaluate the Effects of HSK3486 Administration on Cardiac Repolarization in Healthy Subjects, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-07, primaryCompletionDateStruct date: 2024-05-30, completionDateStruct date: 2024-08-30, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Haisco Pharmaceutical Group Co., Ltd., class: INDUSTRY, descriptionModule briefSummary: Assess the effects of a single IV bolus of HSK3486 single dose on cardiac repolarization for healthy subjects., conditionsModule conditions: Anesthesia, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 48, type: ESTIMATED, armsInterventionsModule interventions name: HSK3486, interventions name: Placebo, interventions name: Moxifloxacin, outcomesModule primaryOutcomes measure: ΔQTcI, secondaryOutcomes measure: ΔHR, ΔQTcF, ΔPR, and ΔQRS, secondaryOutcomes measure: Categorical outliers for QTcI, QTcF, HR, PR, and QRS intervals, secondaryOutcomes measure: AE and SAE, secondaryOutcomes measure: Cmax, secondaryOutcomes measure: AUClast, secondaryOutcomes measure: t1/2, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: Beijing GoBroad Boren Hospital, status: RECRUITING, city: Beijing, country: China, contacts name: Jie Hou, role: CONTACT, phone: 18611422958, email: jie.hou@gohealtharo.com, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False
protocolSection identificationModule nctId: NCT06379854, orgStudyIdInfo id: RCRAHS-ISB/REC/MS-PT/01814, briefTitle: Trunk Rotation And Lateral Flexion Exercises In Stroke Patients, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2024-06, completionDateStruct date: 2024-06, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: In this study we want to introduce the beneficiary combine effects of chest mobilization and chest physiotherapy exercises by using cough peak flow meter and chest expansion in stroke patients. by using theses combine exercises physiotherapist can develop target rehabilitation strategies for stroke survivors., conditionsModule conditions: Stroke, Acute, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 54, type: ESTIMATED, armsInterventionsModule interventions name: chest physiotherapy, interventions name: trunk rotation exercises,deep diaphragmatic also chest physiotherapy, outcomesModule primaryOutcomes measure: Trunk Impairment Scale:, primaryOutcomes measure: Peak Flow Meter, primaryOutcomes measure: Chest Expansion:, eligibilityModule sex: ALL, maximumAge: 50 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Shahida Khaliq Health Centre, status: RECRUITING, city: Islamabad, zip: 44080, country: Pakistan, contacts name: Sara Jahan, MSPT, role: CONTACT, phone: +923415182331, email: saira.jahan@riphah.edu.pk, geoPoint lat: 33.72148, lon: 73.04329, hasResults: False