protocolSection identificationModule nctId: NCT06384690, orgStudyIdInfo id: 4331899, briefTitle: Generating Health Evidence From Dietary Supplementation With a Micro-vegetable Blend, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-01, primaryCompletionDateStruct date: 2024-11-30, completionDateStruct date: 2025-08-31, studyFirstPostDateStruct date: 2024-04-25, lastUpdatePostDateStruct date: 2024-04-25, sponsorCollaboratorsModule leadSponsor name: University of Exeter, class: OTHER, collaborators name: Advanced Growers Limited, collaborators name: Ecog Pro Limited, descriptionModule briefSummary: Micro-vegetables (MV) are seedlings of larger vegetables. They can be grown quickly and are a concentrated source of micronutrients. MV are thought to have broad health benefits, including many inflammatory conditions. These include metabolic, cardiovascular, and cognitive diseases. This could have important implications for the health of an ageing UK population. Less than a third of British adults consume 5 portions of fruit and vegetables per day; this is the level that reduces risk of morbidity and mortality. Vegetables, including MV may - at least in part - exert their health effects by changing the level and type of bacteria in the mouth and gut. Despite their promise, the MV scientific literature is not yet extensive enough to support definitive health claims. It requires the addition of high-quality studies that are relevant to humans. This study will firstly investigate the anti-inflammatory effects on skeletal muscle and adipose tissue in older adults, using a proteomics approach. Second, this study will assess concentrations of circulating inflammatory markers in the sera collected from participants at baseline and at the conclusion of a 6-week period. Further, this study will describe the effects of six weeks MV consumption on cognition, and the oral and gut microbiome. As the bioactive compounds in the MV are owed to the potential beneficial effects for human health, these will be characterised in sera collected from participants., conditionsModule conditions: Inflammation, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule interventions name: Micro-vegetable blend, interventions name: Placebo, outcomesModule primaryOutcomes measure: Tandem Mass Tag (TMT) global proteomics, secondaryOutcomes measure: Concentration of broad panel of inflammatory cytokines, secondaryOutcomes measure: Concentration of circulating bioactive components, secondaryOutcomes measure: Microbiome, secondaryOutcomes measure: Simple Reaction Time, secondaryOutcomes measure: Digit Vigilance, secondaryOutcomes measure: Choice Reaction Time, secondaryOutcomes measure: Pattern Separation, eligibilityModule sex: ALL, minimumAge: 60 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Public Health and Sports Sciences, University of Exeter, status: RECRUITING, city: Exeter, state: Devon, zip: EX1 2LU, country: United Kingdom, contacts name: Cealan Henry, role: CONTACT, email: c.henry3@exeter.ac.uk, geoPoint lat: 50.7236, lon: -3.52751, hasResults: False