protocolSection identificationModule nctId: NCT06385535, orgStudyIdInfo id: IRB_00171031, briefTitle: Clinical Characteristics and Temporal Properties of Individual Tics in Persistent Tic Disorder, acronym: PTD, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-04, primaryCompletionDateStruct date: 2024-12, completionDateStruct date: 2024-12, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: University of Utah, class: OTHER, descriptionModule briefSummary: The goal of this clinical study is to learn more about the timing of tics (sudden, fast movements and sounds that people do and make without meaning to) in people who have multiple tics that have been going on for more than one year. The main questions it aims to answer are:1. See whether a tic's timing is related to other characteristics of the tic, like how long it has been happening and how well the person can control/stop that tic2. See whether the timing of a tic can tell us how well the person can control/stop that tic3. See whether tic treatment changes the timing of tics, and if the timing of a tic has anything to do with how well treatment will work to stop itParticipants will meet with a study researcher to learn more about the study, ask questions, and decide whether or not they would like to be involved. If they decide to do the study, they will meet with the researcher 6 times:1. During the first visit, the study researcher will ask questions about the participant's life, tics, and other psychological symptoms. The researcher will watch the participant's tics for 10 minutes. The participant will do a computer task where they follow instructions to tic or not tic.2. During the second visit, the study researcher will treat one of the participant's tics.3. During the third visit, the study researcher will treat another one of the participant's tics.4. During the fourth visit, the study researcher will treat another one of the participant's tics.5. During the fifth visit, the study researcher will treat another one of the participant's tics.6. During the sixth visit, the study researcher will ask questions about the participant's tics and other psychological symptoms. The participant will do a computer task where they follow instructions to tic or not tic., conditionsModule conditions: Tics, conditions: Tic Disorders, conditions: Vocal Tic, conditions: Motor Tic, conditions: Tourette Syndrome, conditions: Tourette Syndrome in Children, conditions: Tourette Syndrome in Adolescence, conditions: Tics/Tremor, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Clinical trial with a single arm (i.e., participants are not assigned to groups)., primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, maskingDescription: The Principal Investigator and Outcomes Assessors will be blinded to the fractal properties of participants' tics until all study procedures have been completed., enrollmentInfo count: 12, type: ESTIMATED, armsInterventionsModule interventions name: Habit Reversal Training (HRT), outcomesModule primaryOutcomes measure: Estimates of baseline individual and total tic fractality within free-to-tic (FTT) and differential reinforcement of other behavior (DRO) environmental contingencies, primaryOutcomes measure: Voluntary tic suppression success at baseline, primaryOutcomes measure: Total tic severity at baseline as measured by the Yale Global Tic Severity Scale (YGTSS), primaryOutcomes measure: Total and individual tic severity at baseline as measured by the Parent Tic Questionnaire (PTQ), primaryOutcomes measure: Changes in voluntary individual and total tic suppression success pre- and post-intervention, primaryOutcomes measure: Changes in individual and total tic fractality within free-to-tic (FTT) and differential reinforcement of other behavior (DRO) environmental contingencies pre- and post-intervention, primaryOutcomes measure: Changes in individual and total tic severity pre- and post-intervention as measured by the Yale Global Tic Severity Scale (YGTSS) and Parent Tic Questionnaire (PTQ), secondaryOutcomes measure: Individual and total premonitory urge severity at baseline as measured by the Individualized Premonitory Urge for Tics Scale (I-PUTS), secondaryOutcomes measure: Individual and total premonitory urge severity post-intervention as measured by the Individualized Premonitory Urge for Tics Scale (I-PUTS), secondaryOutcomes measure: Changes in individual and total premonitory urge severity pre- and post-intervention as measured by the Individualized Premonitory Urge for Tics Scale (I-PUTS), secondaryOutcomes measure: Total tic severity post-intervention as measured by the Yale Global Tic Severity Scale (YGTSS), secondaryOutcomes measure: Individual and total tic severity post-intervention as measured by the Parent Tic Questionnaire (PTQ), secondaryOutcomes measure: Voluntary tic suppression success post-intervention, secondaryOutcomes measure: Estimates of individual and total tic fractality within free-to-tic (FTT) and differential reinforcement of other behavior (DRO) environmental contingencies post-intervention, eligibilityModule sex: ALL, minimumAge: 8 Years, maximumAge: 12 Years, stdAges: CHILD, contactsLocationsModule locations facility: University of Utah, status: RECRUITING, city: Salt Lake City, state: Utah, zip: 84112, country: United States, contacts name: Kirsten Bootes, MS, role: CONTACT, phone: 801-585-7114, email: kirsten.bootes@psych.utah.edu, contacts name: Kirsten Bootes, MS, role: CONTACT, email: theticlab@utah.edu, geoPoint lat: 40.76078, lon: -111.89105, documentSection largeDocumentModule largeDocs typeAbbrev: ICF, hasProtocol: False, hasSap: False, hasIcf: True, label: Informed Consent Form, date: 2023-12-11, uploadDate: 2024-01-30T18:49, filename: ICF_000.pdf, size: 244576, hasResults: False