protocolSection identificationModule nctId: NCT06335836, orgStudyIdInfo id: 2024-SR-127, secondaryIdInfos id: 2024-SR-127, type: OTHER, domain: Ethics Committee of Nanjing Medical University, briefTitle: The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD), statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2028-12-30, completionDateStruct date: 2028-12-30, studyFirstPostDateStruct date: 2024-03-28, lastUpdatePostDateStruct date: 2024-03-28, sponsorCollaboratorsModule leadSponsor name: The First Affiliated Hospital with Nanjing Medical University, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to learn about the effects of social isolation and social interaction on the risk of dementia progression and brain function in SCD1. To explore the association between social isolation and lonely SCD populations and the occurrence and progression of MCI and AD through cross-sectional studies, cohort studies and randomized controlled trials of SCD;2. To clarify the correlation between different carrier states, resting brain function connectivity characteristics, and dual-task walking ability of APOEε4 allele and the progression of SCD to MCI and AD during the cognitive progress of people with SCD affected by social isolation;3. Establish a predictive model of cognitive decline from SCD to MCI and AD, and apply it to the SCD population to carry out individualized interventions;4. Confirm the protective effect of social interaction on cognitive level and brain function in SCD patients., conditionsModule conditions: Social Isolation, conditions: SCD, conditions: Subjective Cognitive Decline, conditions: MCI, conditions: Mild Cognitive Impairment, conditions: AD, conditions: Alzheimer Disease, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 209, type: ESTIMATED, armsInterventionsModule interventions name: social isolation, outcomesModule primaryOutcomes measure: Incidence of Mild Cognitive Impairment (MCI), primaryOutcomes measure: Incidence of Alzheimer's disease (AD), secondaryOutcomes measure: AVLT-H, secondaryOutcomes measure: MoCA, secondaryOutcomes measure: WMS-RLM, secondaryOutcomes measure: WDS, secondaryOutcomes measure: VFT, secondaryOutcomes measure: BNT, secondaryOutcomes measure: LSNS-6, secondaryOutcomes measure: UCLA, secondaryOutcomes measure: GDS, secondaryOutcomes measure: PSQI, secondaryOutcomes measure: DTC, secondaryOutcomes measure: fMRI, secondaryOutcomes measure: tau, secondaryOutcomes measure: Aβ, secondaryOutcomes measure: APOE genotyping, secondaryOutcomes measure: TMT-A, TMT-B, eligibilityModule sex: ALL, minimumAge: 45 Years, maximumAge: 85 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The First Affiliated Hospital of Nanjing Medical University, status: RECRUITING, city: Nanjing, state: China, Jiangsu, zip: 210000, country: China, contacts name: Zhu Yi, role: CONTACT, phone: +86 137 0516 4030, email: ZhuYi1981@njmu.edu.cn, contacts name: Shi Chunxu, role: CONTACT, phone: +8618625175592, email: scx_0212@outlook.com, geoPoint lat: 32.06167, lon: 118.77778, hasResults: False