protocolSection identificationModule nctId: NCT06372405, orgStudyIdInfo id: PSP-501/D125/79/00000, briefTitle: Instructed Cognitive Reappraisal in Reducing Affective, Behavioral and Psychophysiological Symptoms of Misophonia, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-18, primaryCompletionDateStruct date: 2024-12, completionDateStruct date: 2025-09-30, studyFirstPostDateStruct date: 2024-04-18, lastUpdatePostDateStruct date: 2024-04-18, sponsorCollaboratorsModule leadSponsor name: University of Warsaw, Poland, class: OTHER, collaborators name: Duke University, descriptionModule briefSummary: Misophonia is a disorder causing intense reactions to specific sounds, disrupting daily life. Current treatments lack evidence-based support. The goal of this study is to explore the effectiveness of cognitive reappraisal (CR) in reducing misophonic responses. The study involves 100 participants assigned to either a 4-week CR program or Autogenic Training. Emotional regulation, symptoms of anxiety and depression, quality of life, and more will be assessed using various questionnaire-based measures; perseverations with a task-based test (Wisconsin Card Sorting Test); the presence of psychiatric and personality disorders using face-to-face interviews (The Mini-International Neuropsychiatric Interview (M.I.N.I.) and "Structured Clinical Interview for DSM-5® Personality Disorders" (SCID-5-PD), conditionsModule conditions: Misophonia Treatment, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 108, type: ESTIMATED, armsInterventionsModule interventions name: Cognitive reappraisal, interventions name: Schultz Autogenic Training, outcomesModule primaryOutcomes measure: Change in misophonia symptoms measured by S-Five - Externalizing subscale, primaryOutcomes measure: Change in misophonia symptoms measured by S-Five - Internalizing subscale, primaryOutcomes measure: Change in misophonia symptoms measured by S-Five - Threat subscale, primaryOutcomes measure: Change in misophonia symptoms measured by S-Five - Impact subscale, primaryOutcomes measure: CHange in misophonia symptoms measured by S-Five - Outburst subscale, primaryOutcomes measure: Change of aversiveness rating (valence/pleasure) on the Manikin Scales., primaryOutcomes measure: Change of arousal rating on the Manikin Scales., primaryOutcomes measure: Change in Galvanic Skin Response, primaryOutcomes measure: Change in average HR during the trigger presentation, primaryOutcomes measure: Diagnosis of personality disorders as a predictor of worse treatment outcome., primaryOutcomes measure: Working Alliance Inventory will be related to better treatment outcomes., secondaryOutcomes measure: Meeting criteria for psychiatric disorders -, secondaryOutcomes measure: Hearing test - standard and high frequency pure-tone audiometry, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: Faculty of Psychology, University of Warsaw, status: RECRUITING, city: Warsaw, state: Masovian Voivodeship, zip: 00-183, country: Poland, contacts name: Marta Siepsiak, PhD, role: CONTACT, phone: 0048661152533, email: marta.siepsiak@psych.uw.edu.pl, contacts name: Marta Siepsiak, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.22977, lon: 21.01178, hasResults: False