protocolSection identificationModule nctId: NCT06366386, orgStudyIdInfo id: 5K43TW011963-03, type: NIH, link: https://reporter.nih.gov/quickSearch/5K43TW011963-03, briefTitle: Integrating Hypertension Management in DSD for HIV, acronym: HTN-DSD, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-05-30, completionDateStruct date: 2026-05-30, studyFirstPostDateStruct date: 2024-04-15, lastUpdatePostDateStruct date: 2024-04-18, sponsorCollaboratorsModule leadSponsor name: Infectious Diseases Research Collaboration, Uganda, class: OTHER, descriptionModule briefSummary: The goal of this implementation science study is to design evidence based and stakeholder informed implementation strategies to integrate the management of hypertension (HTN) into existing community anti-retro-viral treatment (ART) delivery models of HIV care in Uganda and evaluate their effectiveness and implementation outcomes. The main questions it aims to answer are:1. What are the perspectives of patients (hypertensive PLHIV) on integrating hypertension care in community ART delivery models of HIV care?2. What are the perspectives of health care providers', district leaders', and policymakers' perspectives on integrating hypertension care in community ART delivery models of HIV care?3. What implementation strategies would support integration of the management of hypertension into existing community ART delivery models in Uganda?4. What is the effectiveness of implementation strategies to integrate the management of hypertension care in community ART delivery models of HIV care in Uganda?5. What are the implementation outcomes of strategies to integrate hypertension care in community ART delivery models of HIV care in Uganda?6. What is the cumulative incidence, types and severity of HTN medication-related adverse events and their predictors among PLHIV with HTN? Investigators will use qualitative research methods to explore key stakeholders' perspectives and preferences on integrating hypertension care in community ART delivery models in Uganda; design implementation strategies that integrate the management of hypertension into existing community ART delivery models; determine the effectiveness of implementation strategies that integrate the management of hypertension in community ART delivery models; evaluate implementation outcomes of strategies that integrate hypertension care in community ART delivery models; determine the cumulative incidence, types and severity of medication-related adverse events and their predictors; and assess the patients and provider costs, health related quality of life, cost-effectiveness of leveraging existing HIV differentiated service delivery models to screen and treat HTN among persons with HIV in Uganda., conditionsModule conditions: Hypertension, conditions: HIV, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 1100, type: ESTIMATED, armsInterventionsModule interventions name: Screening and treatment of hypertension among PLHIV in DSD models for HIV, outcomesModule primaryOutcomes measure: Number of PLHIV with controlled blood pressure (both systolic and diastolic blood pressure), primaryOutcomes measure: % of PLHIV with controlled blood pressure (both systolic and diastolic blood pressure), secondaryOutcomes measure: Mean blood pressure (both systolic and diastolic blood pressure), secondaryOutcomes measure: Number and % of hypertensive PLHIV with suppressed Viral load, secondaryOutcomes measure: Number and % of patients retained in care, secondaryOutcomes measure: Number and % of PLHIV screened for HTN at least once in six months, secondaryOutcomes measure: Implementation costs, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Infectious Diseases Research Collaborations (IDRCUganda), city: Kampala, state: Central, zip: +256, country: Uganda, contacts name: Martin Muddu, MMED, role: CONTACT, phone: +256774004308, email: muddu.martin@gmail.com, geoPoint lat: 0.31628, lon: 32.58219, hasResults: False