hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06267781, orgStudyIdInfo id: TRANSPLANT-PRO, briefTitle: RRMS: Disease PROgression and Myeloid Profiling After Bone Marrow TRANSPLANTation and Second Line Therapies, acronym: TRANSPLANTPRO, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-09-02, primaryCompletionDateStruct date: 2027-09-02, completionDateStruct date: 2027-09-02, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-02-20, sponsorCollaboratorsModule leadSponsor name: IRCCS San Raffaele, class: OTHER, descriptionModule briefSummary: To study whether highly effective therapies can halt disease progression in people with multiple sclerosis by modulating the peripheral myeloid landscape., conditionsModule conditions: Multiple Sclerosis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Number of fading/disappearing paramagnetic rim lesions (PRLs), secondaryOutcomes measure: Surrogate biomarkers of disease progression (MSFC), secondaryOutcomes measure: Surrogate biomarkers of disease progression (sNfL), secondaryOutcomes measure: Surrogate biomarkers of disease progression (RNFL), secondaryOutcomes measure: Surrogate biomarkers of disease progression (cortical lesions), secondaryOutcomes measure: Surrogate biomarkers of disease progression (atrophy), secondaryOutcomes measure: Changes in myeloid landscape, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: IRCCS San Raffaele, status: RECRUITING, city: Milan, zip: 20132, country: Italy, contacts name: Massimo Filippi, MD, role: CONTACT, phone: 00390226433054, email: filippi.massimo@hsr.it, contacts name: Anna A. Bellini, MD, role: CONTACT, phone: 00390226432154, email: bellini.anna@hsr.it, geoPoint lat: 45.46427, lon: 9.18951, documentSection largeDocumentModule largeDocs typeAbbrev: Prot_SAP, hasProtocol: True, hasSap: True, hasIcf: False, label: Study Protocol and Statistical Analysis Plan, date: 2022-05-03, uploadDate: 2024-02-15T03:19, filename: Prot_SAP_000.pdf, size: 10630791, hasResults: False
protocolSection identificationModule nctId: NCT06267768, orgStudyIdInfo id: REC Reference No.:HE-OT2023/13, secondaryIdInfos id: Proj.Ref.No.: 2023/3007-R7052, type: OTHER_GRANT, domain: Research Donation Fund, Hong Kong Metropolitan University, briefTitle: The Effects of Inspiratory Pressures on Diaphragmatic Contraction in People After Stroke, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2025-11-30, completionDateStruct date: 2025-11-30, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: Hong Kong Metropolitan University, class: OTHER, collaborators name: Shenzhen Second People's Hospital, descriptionModule briefSummary: This is a cross-sectional study to determine the optimal inspiratory muscle training (IMT) intensity for stroke survivors. Participants will breathe through a pressure threshold inspiratory loading device with varying loads in random order. Each IMT intensity protocol consists of 10 breaths. During the test, accessory inspiratory muscle activity will be measured with surface electromyography (sEMG) and diaphragm thickness will be used to assessed with ultrasonography. Repeated-measures ANOVA will be used for statistical analysis to determine the most effective training intensity for future study., conditionsModule conditions: Stroke, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 130, type: ESTIMATED, armsInterventionsModule interventions name: Various intensities of inspiratory muscle training, outcomesModule primaryOutcomes measure: Diaphragmatic thickening fraction, secondaryOutcomes measure: Muscle activation of the sternocleidomastoid muscle, secondaryOutcomes measure: Perceived Exertion Borg scale, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, documentSection largeDocumentModule largeDocs typeAbbrev: Prot_SAP, hasProtocol: True, hasSap: True, hasIcf: False, label: Study Protocol and Statistical Analysis Plan, date: 2023-12-29, uploadDate: 2024-01-08T21:03, filename: Prot_SAP_000.pdf, size: 563906, largeDocs typeAbbrev: ICF, hasProtocol: False, hasSap: False, hasIcf: True, label: Informed Consent Form, date: 2023-12-29, uploadDate: 2024-02-15T09:59, filename: ICF_001.pdf, size: 197199, hasResults: False
protocolSection identificationModule nctId: NCT06267755, orgStudyIdInfo id: P.T.REC/012/004884, briefTitle: Efficacy of Extracorporeal Shockwave Therapy on Ultrasonography Changes of Upper Trapezius Myofascial Trigger Points in Patients With Non Specific Neck Pain, acronym: MTP, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-02-20, primaryCompletionDateStruct date: 2024-08-30, completionDateStruct date: 2024-08-30, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-02-20, sponsorCollaboratorsModule leadSponsor name: Cairo University, class: OTHER, descriptionModule briefSummary: this study will be conducted to investigate the effect of Extracorporeal Shockwave Therapy on Ultrasonography Changes of Upper Trapezius Myofascial Trigger Points in Patients With Non Specific Neck Pain, conditionsModule conditions: Neck Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: extracorporeal shockwave and traditional therapy, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: opaque sealed envelope, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Extracorporeal Shockwave therapy, interventions name: Traditional physical therapy, outcomesModule primaryOutcomes measure: muscle thickness, primaryOutcomes measure: hypoechoic area intensity, secondaryOutcomes measure: neck disability, secondaryOutcomes measure: pressure pain threshold, secondaryOutcomes measure: cervical range of motion, secondaryOutcomes measure: pain intensity, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06267742, orgStudyIdInfo id: CHN097, briefTitle: Clinical Trial to Evaluate MDW for Early Detection of Sepsis, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-06-23, primaryCompletionDateStruct date: 2024-03-31, completionDateStruct date: 2024-09-30, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Beckman Coulter, Inc., class: INDUSTRY, collaborators name: Peking Union Medical College Hospital, collaborators name: West China Hospital, collaborators name: Second Affiliated Hospital, School of Medicine, Zhejiang University, descriptionModule briefSummary: This study is intended to clinically verify Monocyte Distribution Width (MDW) parameter of DxH 900 Hematology Analyzer for use in early detection and risk assessment of sepsis, severe sepsis, and septic shock in critically ill patients in Emergency Department (ED). This study is also aimed to provide study supporting data for the product to be marketed in China., conditionsModule conditions: Sepsis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 2200, type: ESTIMATED, armsInterventionsModule interventions name: Complete Blood Count (CBC) with Differential, outcomesModule primaryOutcomes measure: sensitivity, specificity, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 89 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Peking Union Medical College Hospital, status: RECRUITING, city: Beijing, country: China, contacts name: Huadong Zhu, MD, role: CONTACT, geoPoint lat: 39.9075, lon: 116.39723, locations facility: West China Hospital, Sichuan University, status: RECRUITING, city: Chengdu, country: China, contacts name: Yaxiong Zhou, MD, role: CONTACT, geoPoint lat: 30.66667, lon: 104.06667, locations facility: The Second Affiliated Hospital of Zhejiang University School of Medicine, status: RECRUITING, city: Hangzhou, country: China, contacts name: Mao Zhang, MD, role: CONTACT, geoPoint lat: 30.29365, lon: 120.16142, hasResults: False
protocolSection identificationModule nctId: NCT06267716, orgStudyIdInfo id: 274-2023, briefTitle: Pericapsular Nerve Block and Iliopsoas Fascial Plane Block in Hip Surgery, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-23, primaryCompletionDateStruct date: 2024-07-30, completionDateStruct date: 2024-08-30, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Haseki Training and Research Hospital, class: OTHER, descriptionModule briefSummary: This prospective randomized interventional study aims to compare the effects of two peripheral nerve blocks, the periencapsular nerve block (PENG) and iliopsoas block (IPB), on analgesia and motor function after hip surgery.The main questions it aims to answer are the effectivity of postoperative pain management the preservation of motor movement.Participants will receive standardized general anesthesia and postoperative PENG or IPB in either Group.Researchers will compare the total amount of rescue analgesia and numeric rating scale with accompanying evaluating motor function at the same time intervals within 24 hour., conditionsModule conditions: Hip Fractures, conditions: Peripheral Nerve Block, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: prospective randomized standardized triple-blind, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: DOUBLE, maskingDescription: The participants under general anaesthesia and the orthopaedic surgeon responsible for the study will be blinded to the study groups and the specific block procedures. This surgeon will serve as the sole evaluator of postoperative outcomes. Intraoperative results will be recorded by the anaesthesia technician, who is present in the operating room and unaware of the block procedures. Moreover, the data analysis will be conducted before the data are unblinded., whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: PENG block, interventions name: IPB, outcomesModule primaryOutcomes measure: postoperative motor block, secondaryOutcomes measure: pain scores, secondaryOutcomes measure: total analgesia, intraoperative, secondaryOutcomes measure: total rescue analgesia, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Haseki Training and Research Hospital, status: RECRUITING, city: Istanbul, state: Sultangazi, zip: 34000, country: Turkey, contacts name: Berna Caliskan, role: CONTACT, phone: +905067108770, email: caliskan.b@gmail.com, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06267703, orgStudyIdInfo id: 2023-01939_VR, briefTitle: Multi-omics Analyses on Etiology and Early Detection of Stomach Cancer Precursor Lesions, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2026-12-31, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-02-21, sponsorCollaboratorsModule leadSponsor name: Karolinska Institutet, class: OTHER, descriptionModule briefSummary: The overall aim is to utilize multi-omics approach to identify novel etiopathogenesis and early detection biomarkers for stomach cancer precursor lesions. To achieve this aim, first the investigators will use stored serum samples to perform metabolomics profiling among 12,599 twin subjects, among whom 1034 were deemed to have chronic atrophic gastritis based on measured pepsinogen I and II levels. Logistic regression will be used to search for metabolites related to the risk of chronic atrophic gastritis. Second, the investigators will further measure serum proteome by using two quantitatively precise proteomics assays, among the above-mentioned twin subjects. Identified protein biomarkers will be combined with metabolomics biomarkers to create a prediction model for chronic atrophic gastritis. The results will hopefully improve our understanding of the etiological factors and provide promising early detection biomarkers for stomach cancer precursor lesions., conditionsModule conditions: Chronic Atrophic Gastritis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 12599, type: ACTUAL, armsInterventionsModule interventions name: Metabolomic profiling, outcomesModule primaryOutcomes measure: Chronic atrophic gastritis, eligibilityModule sex: ALL, minimumAge: 46 Years, maximumAge: 97 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Karolinska Institutet, city: Solna, state: Stockholm, zip: 17165, country: Sweden, geoPoint lat: 59.36004, lon: 18.00086, hasResults: False
protocolSection identificationModule nctId: NCT06267690, orgStudyIdInfo id: SYSUFAH2021025, briefTitle: A CT-based Radiomics Model to Predict Survival-graded Fibrosis in PDAC, statusModule overallStatus: COMPLETED, startDateStruct date: 2021-01-13, primaryCompletionDateStruct date: 2023-08-31, completionDateStruct date: 2023-08-31, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-02-20, sponsorCollaboratorsModule leadSponsor name: First Affiliated Hospital, Sun Yat-Sen University, class: OTHER, descriptionModule briefSummary: Tumor fibrosis plays an important role in chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC), however there remains a contradiction in the prognostic value of fibrosis. We aimed to investigate the relationship between tumor fibrosis and survival in patients with PDAC, classify patients into high- and low-fibrosis groups, and develop and validate a CT-based radiomics model to non-invasively predict fibrosis before treatment., conditionsModule conditions: Pancreatic Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 295, type: ACTUAL, armsInterventionsModule interventions name: surgery, outcomesModule primaryOutcomes measure: fibrosis, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Shi Siya, city: Guangzhou, state: Guangdong, zip: 510000, country: China, geoPoint lat: 23.11667, lon: 113.25, hasResults: False
protocolSection identificationModule nctId: NCT06267677, orgStudyIdInfo id: 2007/3928, briefTitle: Efficacy of Liquid Versus Powder Protein Supplementation to Optimize Protein Intake After Bariatric Surgery, statusModule overallStatus: COMPLETED, startDateStruct date: 2008-01-02, primaryCompletionDateStruct date: 2008-04-18, completionDateStruct date: 2009-03-06, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-02-20, sponsorCollaboratorsModule leadSponsor name: Hospital Clinic of Barcelona, class: OTHER, descriptionModule briefSummary: The goal of this randomized control trial is to compare the effect of a liquid formula rich in nutrients and low in calories (supplement) with the progressive diet with conventional foods that we usually recommend in patients after surgery. The main question it aims to answer is if the addition of a high-protein, volume-controlled nutritional supplement as a fundamental part of the diet during the first two months after surgery will preserve the patient's nutritional status and prevent the appearance of nutritional deficits and associated complications.Participants will be evaluated at the beginning, at 1 month and at the end of the study (2m) and the following determinations will be made:* Analytical determination* Nitrogen balance by determining urea N2 in 24-hour urine* Anthropometric determinations* Body composition determined by impedanciometry* Resting energy expenditure and nutrient oxidation measured by indirect calorimetry.* Energy, protein and hydration intake.* Gastrointestinal tolerance through self-registration of symptoms. Researchers will compare the effect of a complete hypocaloric liquid formula group with the usual progressive diet group to see if they achieve the protein intake goal established for patients after obesity surgery, preservation of nutritional status and lean mass during the rapid phase of weight loss and the gastrointestinal tolerance during the first two months after surgery., conditionsModule conditions: Body Composition, conditions: Obesity, conditions: Protein Supplementation, conditions: Bariatric Surgery Candidate, conditions: Weight Loss, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 50, type: ACTUAL, armsInterventionsModule interventions name: High protein liquid formula, outcomesModule primaryOutcomes measure: protein intake, primaryOutcomes measure: evaluate nutritional deficiencies, primaryOutcomes measure: Tolerance, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06267651, orgStudyIdInfo id: Steroid in ulcerative colitis, briefTitle: Value Of ACE Index (Albumin, CRP And Endoscopy) In Predicting Intra Venous Steroid Response In Acute Severe Ulcerative Colitis In Assiut University Hospitals, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2025-01, primaryCompletionDateStruct date: 2026-06, completionDateStruct date: 2027-01, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-02-20, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: 1. Determine if the ACE index can predict resoponse to I V steroid in Acute severe ulcerative colitis2. identify on admission a high-risk population who may beneft from earlier second line medical treatment or surgical intervention. ( steroid non responder groups ), conditionsModule conditions: Early Detection of Complication of Ulcerative Colitis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 95, type: ESTIMATED, outcomesModule primaryOutcomes measure: Early prevention of complication of ulcerative colitis, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 50 Years, stdAges: ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06267638, orgStudyIdInfo id: Chomthong hospital, Thailand, briefTitle: Comparison of Postoperative Pain Score Between Perioperative Intravenous Ketamine and Placebo in Patients Undergoing Unilateral Total Knee Arthroplasty Under General Anesthesia, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-22, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: Ministry of Health, Thailand, class: OTHER_GOV, descriptionModule briefSummary: The goal of this clinical trial is to compare postoperative pain score between perioperative intravenous ketamine and placebo in patients undergoing unilateral total knee arthroplasty under general anesthesia. The main question\[s\] it aims to answer are:* Can perioperative intravenous ketamine reduce postoperative pain score during rest and movement at 0, 2, 4, 8, 12, 18, 24 hours better than no administration of Ketamine in patients undergoing Unilateral total knee arthroplasty under general anesthesia?* Can perioperative intravenous ketamine reduce morphine consumption in postoperative 24 hours, length of hospital stay, first time to receive opioid and side effect or complication from ketamine and opioid better than no administration of Ketamine in patients undergoing Unilateral total knee arthroplasty under general anesthesia? Participants will receive intravenous ketamine intraoperative TKA and comparison group will receive placebo that is normal saline. Researchers will compare perioperative intravenous ketamine and placebo to see postoperative pain score, morphine consumption in postoperative 24 hours, length of hospital stay, first time to receive opioid and side effect or complication from ketamine and opioid., conditionsModule conditions: Knee Osteoarthritis, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Ketamine group, interventions name: Placebo group, outcomesModule primaryOutcomes measure: Postoperative pain score at rest and movement, secondaryOutcomes measure: First time to receive intravenous analgesic drug, secondaryOutcomes measure: Morphine consumption, secondaryOutcomes measure: Length of hospital stay, secondaryOutcomes measure: side effect and complication from ketamine and opioid, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 100 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Chomthong hospital, status: RECRUITING, city: Chiangmai, zip: 50160, country: Thailand, contacts name: Numphung Sukantarat, master, role: CONTACT, phone: 66855426519, email: phuang_007@yahoo.com, geoPoint lat: 18.79038, lon: 98.98468, hasResults: False