protocolSection identificationModule nctId: NCT06322277, orgStudyIdInfo id: NETVAC, briefTitle: Use of Low-cost Molecular Diagnostic Techniques as a New Surveillance Model for Diseases Preventable by Vaccinations., statusModule overallStatus: RECRUITING, startDateStruct date: 2021-05-04, primaryCompletionDateStruct date: 2025-02-28, completionDateStruct date: 2025-03-31, studyFirstPostDateStruct date: 2024-03-21, lastUpdatePostDateStruct date: 2024-03-21, sponsorCollaboratorsModule leadSponsor name: Meyer Children's Hospital IRCCS, class: OTHER, descriptionModule briefSummary: Vaccine-preventable disease (VPD) surveillance should be a priority throughout the world. In Italy, however, there is limited attention to the epidemiology of VPDs, with the consequence that their incidence is largely underestimated. Although notification of vaccine-preventable diseases is mandatory, very often the etiologic agents causing VPDs are not identified the etiological agents causing the major and most severe infectious diseases in childhood. Several reasons underlie the underestimation. For example, not having a good surveillance system does not allow us to organize a sustainable prevention project for example based on on the introduction of new vaccinations. For example the limited use of low-cost high-sensitivity techniques such as real-time PCR, which could, if more widely used, improve pathogen identification with 3 times the sensitivity of standard cultural methods. Therefore, the idea of this multicenter, biological sample study is to take advantage of the regional pediatric network with the goal of improving VPD surveillance and increase awareness of the importance of surveillance of preventable diseases with the vaccine within the pediatric network., conditionsModule conditions: Bacterial Infections, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 1, type: ESTIMATED, armsInterventionsModule interventions name: Analysis of biological sample, outcomesModule primaryOutcomes measure: Incidence rate of major VPDs (vaccine-preventable infectious diseases): pertussis, influenza virus, respiratory syncytial virus, S.pneumoniae, N.meningitidis, H.influenzae., secondaryOutcomes measure: Frequency of principal serotype, serogroups of pathogens causative for VPDs., secondaryOutcomes measure: Number of meeting to diffuse the NETVAC results in Tuscany network., eligibilityModule sex: ALL, minimumAge: 1 Day, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Ospedale San Donato, status: RECRUITING, city: Arezzo, country: Italy, contacts name: Marco Martini, role: CONTACT, email: marco.martini@uslsudest.toscana.it, geoPoint lat: 43.46276, lon: 11.88068, locations facility: Immunology Laboratory Meyer Children's Hospital, IRCCS, status: RECRUITING, city: Florence, country: Italy, contacts name: Chiara Azzari, role: CONTACT, phone: +390555662542, email: chiara.azzari@unifi.it, contacts name: Silvia Ricci, role: SUB_INVESTIGATOR, geoPoint lat: 43.77925, lon: 11.24626, locations facility: Meyer Children's Hospital IRCCS, status: RECRUITING, city: Florence, country: Italy, contacts name: Massimo Resti, role: CONTACT, email: massimo.resti@meyer.it, geoPoint lat: 43.77925, lon: 11.24626, locations facility: UO Pediatria Universitaria Ospedale S.Chiara, status: RECRUITING, city: Pisa, country: Italy, contacts name: Diego peroni, role: CONTACT, email: diego.peroni@unipi.it, geoPoint lat: 43.70853, lon: 10.4036, hasResults: False