protocolSection identificationModule nctId: NCT06371976, orgStudyIdInfo id: APH240230, briefTitle: Evaluation of the HPA Axis in Patients With Vasoplegic Syndrome After Cardiac Surgery, acronym: VASOCORT, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-01, primaryCompletionDateStruct date: 2025-04-01, completionDateStruct date: 2025-04-01, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-17, sponsorCollaboratorsModule leadSponsor name: Assistance Publique - Hôpitaux de Paris, class: OTHER, descriptionModule briefSummary: Vasoplegic syndrome after cardiac surgery is common and is associated with increased morbidity and mortality. It is characterized by early and prolonged arterial hypotension, with preserved cardiac output and low systemic vascular resistance. Vasoplegic syndrome therefore shares pathophysiological features with septic shock. There are no data in the literature on the function of the hypothalamic-pituitary-adrenal (HPA) axis during vasoplegic syndrome after cardiac surgery. In situations of acute stress and systemic inflammation, relative adrenal insufficiency has been reported in the most severe patients, particularly those in septic shock. The term ""CIRCI"" (Critical Illness-Related Corticosteroid Insufficiency) is currently defined as an increase in total plasma cortisol of less than 9 µg/dl after stimulation with 250 µg tetracosactide (synthetic ACTH), or a basal total plasma cortisol level of less than 10 µg/dl. However, recent studies have called into question the usefulness of the cosyntropin stimulation test for exploring the HPA axis in intensive care patients.Tandem mass spectrometry (LC-MS/MS) assays can be used to measure steroid metabolites (steroidome), enabling more precise exploration of the corticotropic axis.The aim of this study is to evaluate, on an exploratory basis, the impact of the presence of a post-cardiac surgery vasoplegic syndrome on adrenal function by steroidome mapping (LC-MS/MS)., conditionsModule conditions: Vasoplegic Syndrome in Adult Cardiac Surgery, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 200, type: ESTIMATED, armsInterventionsModule interventions name: Blood sampling, interventions name: Vital status, outcomesModule primaryOutcomes measure: Impact of post-cardiac surgery vasoplegic syndrome on corticotropic function., secondaryOutcomes measure: Evaluate corticotropic function by measuring steroid metabolites according to the presence or absence of ""CIRCI"" in patients with vasoplegic syndrome., secondaryOutcomes measure: Evaluate the association between CIRCI and the severity of vasoplegic syndrome after cardiac surgery., secondaryOutcomes measure: To assess the association between ""CIRCI"" and the duration of post-cardiac surgery vasoplegic syndrome., secondaryOutcomes measure: To assess the association between ""CIRCI"" and length of stay in intensive care., secondaryOutcomes measure: Evaluate the association between ""CIRCI"" and in-hospital mortality, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Pitié-Salpêtrière, city: Paris, state: Ile-de-France, zip: 75013, country: France, contacts name: Adrien Bouglé, MD, PhD, role: CONTACT, phone: 00 33 42 16 29 91, email: adrien.bougle@aphp.fr, contacts name: Jérémie Guillemin, MD, role: CONTACT, phone: 00 33 84 82 82 58, email: jeremie.guillemin@aphp.fr, geoPoint lat: 48.85341, lon: 2.3488, hasResults: False