protocolSection identificationModule nctId: NCT06375889, orgStudyIdInfo id: 69HCL24_0250, secondaryIdInfos id: 2024-A00796-41, type: OTHER, domain: ID-RCB, briefTitle: Platelet Activation in Delayed Cerebral Ischemia Secondary to Aneurysmal Subarachnoid Hemorrhage, acronym: APICRASH, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-13, primaryCompletionDateStruct date: 2025-06-13, completionDateStruct date: 2025-06-13, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Hospices Civils de Lyon, class: OTHER, descriptionModule briefSummary: Aneurysmal subarachnoid haemorrhage is a complex pathology, the pathophysiology of which is still imperfectly understood. Its morbidity and mortality remain significant. In addition to the damage sustained by the brain in the immediate aftermath of aneurysmal rupture, which is inaccessible to life-saving treatment, a significant proportion of lesions occur at a distance from the initial event. Delayed cerebral ischaemia is one of the most morbid complications. It combines an inflammatory pattern with vascular dysfunction and neuronal excitotoxicity, leading to avoidable secondary neuronal loss.Vascular dysfunction is mediated by a loss of homeostasis between endothelial cells and figurative blood cells, including platelets. However, the interrelationship between these elements and the precise chronology of the dysfunction remain imperfectly described to date.It therefore seems appropriate to propose temporal monitoring of platelet activation kinetics over time, combined with concomitant collection of markers of endothelial damage, in order to clarify the vascular chronobiology of this pathology., conditionsModule conditions: Aneuvrysmal Subarachnoid Hemorrhage, conditions: Delayed Cerebral Ischemia, conditions: Endotheliopathy, conditions: Platelets Kinetic, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: blood test, outcomesModule primaryOutcomes measure: The difference in the percentage of platelets expressing P-selectin, reflecting their irreversible activation., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Anaesthesiology and Intensive Care medicine department, Pierre Wertheimer hospital, city: Bron, state: Auvergne-Rhône-Alpes, zip: 69005, country: France, contacts name: Nicolas Chardon, MD;Msc, role: CONTACT, phone: 683396245, phoneExt: 33, email: nicolas.chardon@chu-lyon.fr, contacts name: Nicolas Chardon, MD;msc, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.73333, lon: 4.91667, locations facility: Neurovascular intensive care unit department, Pierre Wertheimer hospital, city: Bron, state: Auvergnes-Rhones-Alpes, zip: 69005, country: France, contacts name: Nicolas Chardon, MD;Msc, role: CONTACT, phone: 683396245, phoneExt: 33, email: nicolas.chardon@chu-lyon.fr, contacts name: Nicolas Chardon, MD;Msc, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.73333, lon: 4.91667, hasResults: False