hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06285435, orgStudyIdInfo id: coagulation activation in PV, briefTitle: Coagulation Activation in Patients With Pemphigus, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-10, completionDateStruct date: 2026-02, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: Aim of work:1. To evaluate the plasma markers of coagulation activation: prothrombin F1+2 and d-dimer levels in pemphigus patients with active disease and compare them with age and sex-matched controls.2. To evaluate the correlation of these markers with disease severity score by using Pemphigus Disease Area Index (PDAI) and with disease activity by measurement of anti-desmoglein 1 and 3 antibody titers., conditionsModule conditions: Pemphigus, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 54, type: ESTIMATED, armsInterventionsModule interventions name: prothrombin fragment 1+2, outcomesModule primaryOutcomes measure: Comparison of coagulation activation markers in pemphigus patients with controls, secondaryOutcomes measure: Correlation of markers with disease severity, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06285422, orgStudyIdInfo id: SC262-101, briefTitle: Study Evaluating SC262 in Subjects With r/r B-cell Malignancies (VIVID), statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2028-03, completionDateStruct date: 2029-03, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-04-04, sponsorCollaboratorsModule leadSponsor name: Sana Biotechnology, class: INDUSTRY, descriptionModule briefSummary: SC262-101 is a Phase 1 study to evaluate SC262 safety and tolerability, anti-tumor activity, cellular kinetics, immunogenicity, and exploratory biomarkers., conditionsModule conditions: Non Hodgkin's Lymphoma, conditions: Large B-cell Lymphoma, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 35, type: ESTIMATED, armsInterventionsModule interventions name: SC262, outcomesModule primaryOutcomes measure: Evaluate safety and tolerability of SC262, secondaryOutcomes measure: Evaluate preliminary anti-tumor activity of SC262, secondaryOutcomes measure: Evaluate cellular kinetics and persistence of SC262, secondaryOutcomes measure: Evaluate cellular kinetics and persistence of SC262, secondaryOutcomes measure: Evaluate cellular kinetics and persistence of SC262, secondaryOutcomes measure: Evaluate host immunogenicity to SC262, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06285383, orgStudyIdInfo id: Kar.neck, briefTitle: The Effects of Music on Neck Pain, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-15, primaryCompletionDateStruct date: 2024-03-15, completionDateStruct date: 2024-04-15, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: KTO Karatay University, class: OTHER, descriptionModule briefSummary: The effects of passive music listening on pain, anxiety and quality of life in patients with chronic neck pain in addition to physical therapy will be examined., conditionsModule conditions: Pain, Chronic, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Music listening, interventions name: classic physical therapy, outcomesModule primaryOutcomes measure: Beck anxiety inventory, primaryOutcomes measure: Visual Analogue Scale, primaryOutcomes measure: Short form-36, eligibilityModule sex: ALL, minimumAge: 30 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: Mustafa Savaş Torlak, status: RECRUITING, city: Karatay, state: Eyalet/Yerleşke, zip: 42000, country: Turkey, contacts name: Mustafa S Torlak, role: CONTACT, phone: +905373660138, email: mustafa.savas.torlak@karatay.edu.tr, geoPoint lat: 37.86726, lon: 32.52863, hasResults: False
protocolSection identificationModule nctId: NCT06285357, orgStudyIdInfo id: EPISTOP_22, briefTitle: The Effect of the Association EGCG, Folic Acid and Vitamin B12 in Preventing the Persistence of HPV Infection., statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-19, primaryCompletionDateStruct date: 2025-02, completionDateStruct date: 2025-12, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-18, sponsorCollaboratorsModule leadSponsor name: Lo.Li.Pharma s.r.l, class: INDUSTRY, descriptionModule briefSummary: The purpose of the study is to test the effect of the administration of a dietary supplement consisting of epigallocatechin gallate (EGCG), vitamin B12 and folic acid in the treatment of infections with papilloma virus of the cervix., conditionsModule conditions: HPV Infection, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: EGCG + folic acid + B12, outcomesModule primaryOutcomes measure: HPV DNA test negativity, eligibilityModule sex: FEMALE, minimumAge: 25 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Azienda Ospedaliero-Universitaria di Modena, status: RECRUITING, city: Modena, zip: 41124, country: Italy, contacts name: Giovanni Grandi, role: CONTACT, geoPoint lat: 44.64783, lon: 10.92539, hasResults: False
protocolSection identificationModule nctId: NCT06285344, orgStudyIdInfo id: kilis_3, briefTitle: Impact of Workload and Fatigue on Sleep in OR Nurses, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2024-05-01, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Kilis 7 Aralik University, class: OTHER, collaborators name: Hasan Kalyoncu University, descriptionModule briefSummary: This study aims to explore the impact of individual workload and fatigue levels on the sleep quality of operating room (OR) nurses, highlighting a critical aspect of healthcare professionals' well-being that directly affects patient safety and care quality. Operating room nurses face unique challenges due to the high-stress, fast-paced environment of surgical settings, which can lead to increased stress levels, emotional challenges, and a higher incidence of fatigue compared to other nursing specialties. Factors contributing to this fatigue include the demanding nature of surgical procedures, the need for constant vigilance, and the irregular hours associated with shift work, all of which can impair sleep quality.The literature review suggests that while the relationship between workload, fatigue, and sleep quality has been extensively studied in general nursing populations, there is a lack of specific focus on operating room nurses. These professionals work under distinct conditions that may exacerbate the effects of workload and fatigue on sleep quality, yet comprehensive studies targeting this group are limited. Understanding the nuances of how workload and fatigue specifically impact the sleep quality of OR nurses is crucial for developing targeted interventions aimed at improving their health and job performance, thereby enhancing patient care and safety.This cross-sectional and correlational study seeks to fill the gap in the literature by examining the specific effects of workload and fatigue on sleep perception among OR nurses. By identifying these relationships, the study aims to contribute valuable insights into strategies for mitigating fatigue and improving sleep among this critical group of healthcare workers, with the ultimate goal of ensuring both nurse well-being and patient safety., conditionsModule conditions: Shift Work, conditions: Sleep Perception, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 250, type: ESTIMATED, outcomesModule primaryOutcomes measure: Demographic Information Form, primaryOutcomes measure: Individual Workload Perception Scale (IWPS), primaryOutcomes measure: Chalder Fatigue Scale (CFS), primaryOutcomes measure: Richard-Campbell Sleep Questionnaire (RCSQ), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Islam Elagöz, city: Kilis, zip: 79100, country: Turkey, geoPoint lat: 36.71611, lon: 37.115, hasResults: False
protocolSection identificationModule nctId: NCT06285331, orgStudyIdInfo id: 2023ZDSYLL483-P01, briefTitle: the Impact of Manual or Mechanical Ways to Perform PLR on the Accuracy of Evaluation of Fluid Responsiveness, acronym: PLR, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-06, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Southeast University, China, class: OTHER, descriptionModule briefSummary: Our goal was to study the impact of different ways to perform passive leg raising (PLR) on the accuracy of evaluation of fluid responsiveness., conditionsModule conditions: Circulatory Failure, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Automatic Bed, interventions name: Manual, outcomesModule primaryOutcomes measure: Accuracy of fluid responsiveness evaluation, secondaryOutcomes measure: Mortality, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Zhongda Hospital Southeast University, status: RECRUITING, city: Nanjing, state: Jiangsu, zip: 210009, country: China, contacts name: Jingyuan Xu, M.D., role: CONTACT, geoPoint lat: 32.06167, lon: 118.77778, hasResults: False
protocolSection identificationModule nctId: NCT06285305, orgStudyIdInfo id: kilis_2, briefTitle: Surgical ICU Nurses' Attitudes on End-of-Life Care, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2024-05-01, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Kilis 7 Aralik University, class: OTHER, collaborators name: Hasan Kalyoncu University, descriptionModule briefSummary: This study aims to explore the attitudes and behaviors of nurses working in surgical intensive care units (ICUs) towards end-of-life care, alongside identifying the barriers they face in providing such care. Despite the universal need for end-of-life care, with an estimated 56.8 million people requiring it annually, only a fraction receive adequate services. The concept of a "good death" has evolved, now emphasizing patient and family wishes, and aligning with clinical, cultural, and ethical standards. In the U.S., a significant portion of deaths occur in hospitals, often involving surgical interventions in the final stages of life. Nurses in ICUs play a crucial role in delivering end-of-life care, making their attitudes and behaviors pivotal to the quality of care provided. Previous studies have indicated a positive correlation between nurses' attitudes towards end-of-life care and their ethical conduct in care delivery. However, research specifically focusing on surgical ICU nurses and the challenges they encounter in end-of-life care is limited. This study seeks to fill that gap, enhancing understanding of the factors that influence end-of-life care in surgical ICUs and potentially guiding improvements in care practices and policy., conditionsModule conditions: PATİENT CARE, conditions: Intensive Care Unit, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CROSSOVER, timePerspective: PROSPECTIVE, enrollmentInfo count: 250, type: ESTIMATED, outcomesModule primaryOutcomes measure: Descriptive Information Form, primaryOutcomes measure: Attitudes and Behaviors Towards End-of-Life Care Scale for Intensive Care Nurses, primaryOutcomes measure: Barriers to End-of-Life Care in Surgical Intensive Care Form, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Islam, city: Kilis, zip: 79100, country: Turkey, geoPoint lat: 36.71611, lon: 37.115, hasResults: False
protocolSection identificationModule nctId: NCT06285292, orgStudyIdInfo id: RC24_0097, briefTitle: Prospective and Comparative Evaluation of a Medical Device Composed of a Perineal Probe Connected to a Mobile Application in the Management of Stress Urinary Incontinence., acronym: PRIME, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06, primaryCompletionDateStruct date: 2024-06, completionDateStruct date: 2026-06, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Nantes University Hospital, class: OTHER, collaborators name: FIZIMED Company, descriptionModule briefSummary: Stress urinary incontinence (SUI) affects around 40% of women and has a major impact on quality of life. The gold standard for the treatment of SUI is pelvicfloor rehabilitation, but this presents constraints in terms of availability of healthcare professionals, as well as organization and travel for patients. Innovative devices offer self-training exercises for the pelvicfloor, thus promoting motivation and adherence to treatment. The hypothesis of this study is to prove that the use of a pelvicfloor medical device combined with 2 rehabilitation sessions is not inferior to pelvic-perineal rehabilitation., conditionsModule conditions: Urinary Incontinence, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 138, type: ESTIMATED, armsInterventionsModule interventions name: EMY, outcomesModule primaryOutcomes measure: Urinary symptoms using the ICIQ-UI SF questionnaire, secondaryOutcomes measure: Quality of life using the I-QoL questionnaire, secondaryOutcomes measure: Urinary symptoms using the ICIQ-UI SF questionnaire, secondaryOutcomes measure: Cost-utility ratio using the EQ-5D questionnaire, secondaryOutcomes measure: Qualitative component, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06285279, orgStudyIdInfo id: NJCT-2401, briefTitle: FKC288 in Participants With Autoimmune Kidney Diseases, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-04, primaryCompletionDateStruct date: 2026-12-31, completionDateStruct date: 2028-12-31, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: Nanjing University School of Medicine, class: OTHER, descriptionModule briefSummary: This study is a single-center, open-label, dose-escalation exploratory clinical trial, expected to enroll 6 to 12 participants. It will use a BOIN (Bayesian Optimal Interval) design for dose escalation, with four predetermined dose groups (0.3×10\^6 cells/kg, 1.0×10\^6 cells/kg, 3.0×10\^6 cells/kg, and an alternative dose of 0.1×10\^6 cells/kg). Each dose group plans to enroll 1-2 or 3-6 participants with relapsed or refractory autoimmune-mediated kidney diseases (such as lupus nephritis, ANCA-associated vasculitis, membranous nephropathy, and IgG4-related diseases)., conditionsModule conditions: Lupus Nephritis, conditions: ANCA-associated Vasculitis, conditions: Membranous Nephropathy - PLA2R Induced, conditions: IgG4-Related Diseases, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 24, type: ESTIMATED, armsInterventionsModule interventions name: FKC288, outcomesModule primaryOutcomes measure: The proportion of subjects with dose-limiting toxicity, primaryOutcomes measure: The proportion of subjects with adverse events, secondaryOutcomes measure: Proportion of subjects achieving renal response, secondaryOutcomes measure: Duration of response (DoR) of all subjects, secondaryOutcomes measure: Progression-free survival (PFS) of all subjects, secondaryOutcomes measure: Overall survival (OS) of all subjects, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Jinling Hospital, status: RECRUITING, city: Nanjing, state: Jiangsu, zip: 210016, country: China, contacts name: Xianghua Huang, MD, role: CONTACT, phone: 13770648824, email: hxhszb@163.com, geoPoint lat: 32.06167, lon: 118.77778, hasResults: False
protocolSection identificationModule nctId: NCT06285266, orgStudyIdInfo id: kilis_1, briefTitle: Nursing Students' Perceptions and Participation in Surgical Clinical Learning, acronym: NSPSCP_CL, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-15, primaryCompletionDateStruct date: 2024-04-30, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Kilis 7 Aralik University, class: OTHER, collaborators name: Hasan Kalyoncu University, descriptionModule briefSummary: This cross-sectional study investigates the perceptions of nursing students regarding the clinical learning environment (CLE) in surgical services and their participation in clinical practices. Surgical services present a complex, dynamic, and intense learning environment crucial for the development of nursing students' professional competencies. The study explores the challenges nursing students face in these settings, including limited opportunities for participation in intraoperative processes and intensive care units, and the impact of these challenges on their learning outcomes and professional development.Previous research has highlighted various factors that can either facilitate or hinder nursing students' ability to engage effectively in clinical practices, such as the learning atmosphere, support from nurse educators, peer support, and effective communication. However, there is a noted gap in understanding the specific difficulties encountered in surgical services, the adequacy of students' clinical skills and knowledge, and their ability to apply theoretical knowledge in practice.By examining nursing students' experiences, this study aims to shed light on the suitability and quality of CLEs in surgical services, contributing valuable insights for optimizing clinical learning and enhancing nursing education programs. The hypotheses tested whether nursing students' perceptions of CLEs in surgical services and their participation in clinical practices are influenced by their descriptive characteristics.Keywords: Nursing Student, Surgical Services, Clinical Practice, Clinical Learning Environment, conditionsModule conditions: Clinical Practice, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 100, type: ESTIMATED, outcomesModule primaryOutcomes measure: Descriptive Characteristics Form, primaryOutcomes measure: Clinical Learning Environment Scale (CLES):, primaryOutcomes measure: Clinical Practice Participation Determination Form:, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06285240, orgStudyIdInfo id: 1167-007, briefTitle: Efficacy and Safety of MK-1167 in Participants With Alzheimer's Disease Dementia Taking Stable Donepezil Treatment (MK-1167-007), statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-28, primaryCompletionDateStruct date: 2024-07-25, completionDateStruct date: 2024-07-25, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-04-03, sponsorCollaboratorsModule leadSponsor name: Merck Sharp & Dohme LLC, class: INDUSTRY, descriptionModule briefSummary: The main purpose of this study is to assess the safety and efficacy of MK-1167 administered to participants with Alzheimer's Disease (AD) receiving stable Donepezil treatment., conditionsModule conditions: Alzheimer's Disease, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 16, type: ESTIMATED, armsInterventionsModule interventions name: MK-1167, interventions name: Donepezil, interventions name: Placebo, outcomesModule primaryOutcomes measure: Number of participants experiencing an Adverse Event (AE), primaryOutcomes measure: Number of participants discontinuing study treatment due to an AE, secondaryOutcomes measure: Area Under the Plasma Concentration-Time Curve from Dosing to 24 Hours Postdose (AUC0-24) of MK-1167, secondaryOutcomes measure: Maximum Plasma Concentration (Cmax) of MK-1167, secondaryOutcomes measure: Plasma Concentration at 24 hours postdose (C24), secondaryOutcomes measure: Time to Reach Maximum Plasma Concentration (Tmax) of MK-1167, secondaryOutcomes measure: Apparent Terminal Half-Life (t½) of MK-1167, secondaryOutcomes measure: Oral Clearance (CL/F) of MK-1167 from Plasma, secondaryOutcomes measure: Apparent Volume of Distribution (Vz/F) of MK-1167, eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Velocity Clinical Research, Hallandale Beach ( Site 0001), status: RECRUITING, city: Hallandale Beach, state: Florida, zip: 33009, country: United States, contacts name: Study Coordinator, role: CONTACT, phone: 954-455-5757, geoPoint lat: 25.9812, lon: -80.14838, locations facility: CenExel iResearch, LLC ( Site 0003), status: RECRUITING, city: Decatur, state: Georgia, zip: 30030, country: United States, contacts name: Study Coordinator, role: CONTACT, phone: 404-537-1281, geoPoint lat: 33.77483, lon: -84.29631, locations facility: CenExel iResearch, LLC ( Site 0004), status: RECRUITING, city: Savannah, state: Georgia, zip: 31405, country: United States, contacts name: Study Coordinator, role: CONTACT, phone: 912-744-0800, geoPoint lat: 32.08354, lon: -81.09983, hasResults: False