hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06282926, orgStudyIdInfo id: 324811, briefTitle: Role of 3D Echocardiography Knowledge-based Reconstruction in ACHD, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2025-06, completionDateStruct date: 2025-09, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Guy's and St Thomas' NHS Foundation Trust, class: OTHER, collaborators name: Manchester Metropolitan University, descriptionModule briefSummary: The main objective of this study is to evaluate the reproducibility and accuracy of TTE-3DKBR in assessing RV volume and EF compared to the reference method of CMR in a group of ACHD patients with known moderate or severe PR after ToF repair.As part of the validation study, the reproducibility of the TTE-3DKBR in assessing RV volume and EF will also be tested in a group of healthy adult volunteers. Additionally, TTE-3DKBR evaluation will be compared in both groups to the conventional 2D echocardiography measurements used in routine clinical practice, such as tricuspid annular plane systolic excursion (TAPSE), tissue Doppler imaging (TDI), fractional area change (FAC), and global longitudinal strain (GLS).Another objective of the study is also to evaluate the effects of chronic RV volume overload with an interval of one-year follow-up using TTE-3DKBR and compare it with the conventional non-geometric echocardiography measurements, particularly with GLS.The study will end when the required number of patients have been enrolled and when the last subject undergoes the research dataset acquisition. The study may be terminated prematurely if it becomes apparent that the recruitment target cannot be met within the projected recruitment phase., conditionsModule conditions: Tetralogy of Fallot, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 72, type: ESTIMATED, armsInterventionsModule interventions name: Echocardiography assessment, outcomesModule primaryOutcomes measure: Evaluate the reproducibility and accuracy of TTE-3DKBR in assessing RV volume and EF compared to the reference method of CMR in a group of ACHD patients with known moderate or severe PR after ToF repair., primaryOutcomes measure: Evaluate the effects of chronic RV volume overload in this population within one-year follow-up using TTE-3DKBR and compare it with the conventional non-geometric echocardiography measurement of GLS., secondaryOutcomes measure: Compare TTE-3DKBR evaluation to the conventional 2D echocardiography measurements used in routine clinical practice (TAPSE, TDI, FAC, and GLS)., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06282913, orgStudyIdInfo id: ---Oncology-Nursing-2024---, briefTitle: The Effect of Mindfulness Meditation, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2025-11, completionDateStruct date: 2025-12, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Gulhane Training and Research Hospital, class: OTHER_GOV, descriptionModule briefSummary: Cancer is a disease that causes the most deaths worldwide and is challenging for patients and caregivers both physically and psychosocially. Physicians and nurses working in oncology clinics perform a demanding profession providing compassionate care and treatment to patients struggling with life-threatening diseases. The emotional cost of caring for patients diagnosed with cancer can lead to compassion fatigue, burnout, and decreased psychological well-being among healthcare professionals. For this reason, this research is planned as a randomized controlled study to examine the effect of Mindfulness meditation practice on compassion fatigue, burnout, and psychological well-being in physicians and nurses working in oncology units., conditionsModule conditions: Burnout, conditions: Compassion Fatigue, conditions: Psychological Well-Being, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 64, type: ESTIMATED, armsInterventionsModule interventions name: Mindfulness Meditation, outcomesModule primaryOutcomes measure: compassion fatigue, primaryOutcomes measure: burnout, primaryOutcomes measure: psychological well-being, secondaryOutcomes measure: compassion fatigue, secondaryOutcomes measure: burnout, secondaryOutcomes measure: psychological well-being, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06282900, orgStudyIdInfo id: 2024-1/15, briefTitle: Pain and Screen Addiction in University Students, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-04, primaryCompletionDateStruct date: 2024-05, completionDateStruct date: 2024-06, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: Acibadem University, class: OTHER, descriptionModule briefSummary: One of the most important factors why young people spend inactive time is the time they spend in front of the screen. Sedentary screen time refers to time spent using a screen-based device, such as a computer, television, smartphone, or tablet while being sedentary in any environment. The last decade has seen a disturbing increase in the amount of time young people spend in front of screens. Research shows that musculoskeletal disorders in the hand, wrist, arm, and neck occur at a high rate due to long-term and repetitive use of the smartphone, one of the electronic devices. People with musculoskeletal pain often complain of more than one area of pain.The primary purpose of this study is to investigate the relationship between university students' use of various screen-based devices, the time they spend in front of the screen, and the number of painful areas they report on the body. Our secondary aim is to evaluate the relationship between pain, and screen time, and physical activity level., conditionsModule conditions: Student, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 300, type: ESTIMATED, armsInterventionsModule interventions name: University students, outcomesModule primaryOutcomes measure: Investigating the use of screen-based devices, primaryOutcomes measure: Musculoskeletal system evaluation, secondaryOutcomes measure: Physical activity assessment, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 25 Years, stdAges: ADULT, contactsLocationsModule locations facility: Acibadem University, status: RECRUITING, city: Istanbul, state: None Selected, zip: 34752, country: Turkey, contacts name: Elif E Safran, asst. prof., role: CONTACT, phone: 500 4047, phoneExt: 216, email: elif.bayraktar@acibadem.edu.tr, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06282887, orgStudyIdInfo id: 2021-IIT-002, briefTitle: Effects of Music Therapy on Psychological States Among Cancer Patients Undergoing MRI Scans and A Relevant Mediator, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-11-09, primaryCompletionDateStruct date: 2024-11-10, completionDateStruct date: 2024-11-10, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Guangzhou Concord Cancer Center, class: OTHER, descriptionModule briefSummary: The primary objective of this study is to examine the effects of a music therapy protocol on improving anxiety, symptom distress, and relaxation among cancer patients who are going through MRI scanning. Physiological data, such as pulse rates and respiration rates will be collected. Furthermore, data about scanning efficiency will be collected to assess if scanning efficiency is affected by the protocol implementation. The secondary study objective is to assess whether or not there is a relationship between patient attention to music during the intervention process and the changes in anxiety, symptom distress, and relaxation., conditionsModule conditions: Psycho-Oncology, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: DOUBLE, maskingDescription: All participants will be wearing a headphone, and they will not know if there will be music until they experience and finish the scan process.Radiographers are blinding to avoid biases., whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Music therapy, outcomesModule primaryOutcomes measure: Anxiety, primaryOutcomes measure: Symptom distress, primaryOutcomes measure: Relaxation, secondaryOutcomes measure: Pulse rates, secondaryOutcomes measure: Respiration rate, secondaryOutcomes measure: Scanning efficiency, secondaryOutcomes measure: Patient satisfaction level, secondaryOutcomes measure: Patient attention to music (only for the music therapy group), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: GuangZhou Concord Cancer Center, status: RECRUITING, city: Guangzhou, state: Guangdong, zip: 510700, country: China, contacts name: Juan Nie, Masters, role: CONTACT, geoPoint lat: 23.11667, lon: 113.25, hasResults: False
protocolSection identificationModule nctId: NCT06282874, orgStudyIdInfo id: CTONG2303, briefTitle: Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-07-01, completionDateStruct date: 2027-03-01, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Guangdong Association of Clinical Trials, class: OTHER, descriptionModule briefSummary: This study is an investigator-initiated, prospective, open-label, single-arm, multicenter clinical trial aimed at exploring the antitumor activity of Lorlatinib in ALK-positive NSCLC patients with brain/ leptomeningeal metastases., conditionsModule conditions: Carcinoma, Non-Small-Cell Lung, conditions: Brain Metastases, conditions: Leptomeningeal Metastasis, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Lorlatinib, outcomesModule primaryOutcomes measure: intracranial objective response rate（iORR）, secondaryOutcomes measure: Progression-free survival (PFS) and intracranial PFS（iPFS）, secondaryOutcomes measure: Obiective response rate (ORR), secondaryOutcomes measure: Disease control rate (DCR) and intracranial disease control rate (iDCR), secondaryOutcomes measure: Overall survival, secondaryOutcomes measure: Number of participants with adverse events, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Guangdong Provincial Perople's Hospital, city: Guangzhou, state: Other (Non U.s.), zip: 510080, country: China, contacts name: Chang Lu, role: CONTACT, phone: 02083827812, email: luchang@gdpg.org.cn, contacts name: Jin-Ji Yang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 23.11667, lon: 113.25, hasResults: False
protocolSection identificationModule nctId: NCT06282848, orgStudyIdInfo id: HongKongPU_Optometry4, briefTitle: Pharmacological and Non-pharmacological Treatment Effects on Children With Different Predicted Myopia Progression Rate, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2026-12, completionDateStruct date: 2026-12, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: The Hong Kong Polytechnic University, class: OTHER, collaborators name: The University of Hong Kong, descriptionModule briefSummary: The goal of this clinical trial is to compare pharmacological and non-pharmacological treatment effects on the children with different predicted myopia progression rate measured by modified multifocal electroretinogram. The main questions it aims to answer are:* the effectiveness of using 0.05% atropine and prescribing DIMS lens for myopia control in children with different myopia progression rates* the contribution of L/M cones in juvenile myopia progression and changes of retinal activities under atropine and DIMS treatment.Participants will have baseline and follow-up eye examinations and given either pharmacological treatment with 0.05% atropine or non-pharmacological treatment with DIMS lens for myopia control.Researchers will compare the changes of refractive errors and axial length after different types of interventions and investigate the relations between the parameters of mfERG responses and the thicknesses of retinal layers and choroid., conditionsModule conditions: Myopia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized clinical trial, primaryPurpose: PREVENTION, maskingInfo masking: DOUBLE, maskingDescription: Double-blinded, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Atropine 0.05%, interventions name: DIMS lens, outcomesModule primaryOutcomes measure: Subjective refraction, primaryOutcomes measure: Axial length, secondaryOutcomes measure: mfERG responses, secondaryOutcomes measure: Retinal and choroidal thickness, eligibilityModule sex: ALL, minimumAge: 7 Years, maximumAge: 9 Years, stdAges: CHILD, contactsLocationsModule locations facility: School of Optometry, Hong Kong Polytechnic University, status: RECRUITING, city: Hong Kong, zip: 00000, country: Hong Kong, contacts name: Henry HL Chan, PhD, role: CONTACT, phone: 85227667937, email: henryhl.chan@polyu.edu.hk, contacts name: Kaiyip Choi, PhD, role: CONTACT, phone: 85234002934, email: kaiyip.choi@polyu.edu.hk, geoPoint lat: 22.27832, lon: 114.17469, documentSection largeDocumentModule largeDocs typeAbbrev: ICF, hasProtocol: False, hasSap: False, hasIcf: True, label: Informed Consent Form, date: 2023-03-02, uploadDate: 2024-02-21T22:59, filename: ICF_000.pdf, size: 234773, hasResults: False
protocolSection identificationModule nctId: NCT06282835, orgStudyIdInfo id: 2023KY242, briefTitle: Eravacycline Combination Therapy for MRAB, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-26, primaryCompletionDateStruct date: 2024-10-31, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Fujian Medical University Union Hospital, class: OTHER, descriptionModule briefSummary: The goal of this observational study is to learn about the eravacycline combination therapy in multidrug-resistant acinetobacter gaumannii pneumonia. The main question is to evaluate the the effectiveness and safety.Participants will be given Eravacycline and Polymyxin，or other antibiotcs that the Investigator considered suitable. During the clinical trial, participants will be monitored for blood drug concentrations and drug concentrations in the ELF (Epithelial Lining Fluid。Clinical efficacy rate and microbiological clearance rate will be assessed at the same time, conditionsModule conditions: Pulmonary Infection, conditions: Pneumonia, Bacterial, conditions: Acinetobacter Baumannii, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Eravacycline Injection, outcomesModule primaryOutcomes measure: Clinical Responded Rate, secondaryOutcomes measure: The microbiological clearance rate, secondaryOutcomes measure: The all-cause mortality rate within 28 days, secondaryOutcomes measure: "Incidence Rate of Adverse Event, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Fujian Medical University Union hospital, status: RECRUITING, city: Fuzhou, state: Fujian, zip: 350000, country: China, contacts name: Hui Zhang, Phd, role: CONTACT, phone: 13015723860, email: xhzh@fjmu.edu.cn, geoPoint lat: 26.06139, lon: 119.30611, hasResults: False
protocolSection identificationModule nctId: NCT06282822, orgStudyIdInfo id: HFpEF-SWE, briefTitle: Shear Wave Elastography for Diagnosis of Heart Failure With Preserved Ejection Fraction, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2024-10-31, completionDateStruct date: 2025-03-01, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: First Hospital of China Medical University, class: OTHER, descriptionModule briefSummary: The diagnosis of heart failure with preserved ejection fraction (HFpEF) is often complex. Echocardiography has the advantages of being a non-invasive, simple operation, low price, and high repeatability, and is of great value in the diagnosis of HFpEF. However, the current echocardiographic assessment of left ventricular diastolic dysfunction and elevated filling pressure is based on multi-parameter indirect judgment, and new parameters are urgently needed to achieve accurate judgment of left ventricular diastolic function and an accurate diagnosis of HFpEF. Myocardial stiffness refers to the ability of the myocardium to undergo stress and strain. It is an important part of the pathophysiology of cardiac diastolic dysfunction and an important parameter for clinical evaluation of the diastolic function of HFpEF. Shear-wave elastography is a novel ultrasound-based elastography technology. Based on the shear wave generated by the remote induction of the radiation force of the focused ultrasound beam, the hardness of myocardial tissue can be measured quantitatively, locally, and noninvasively, and the change in myocardial stiffness in patients with HFpEF can be directly reflected. Currently, no relevant studies have applied shear-wave elastography to the diagnosis of HFpEF. This study aims to identify changes in myocardial stiffness measured by shear-wave elastography in patients with HFpEF based on a multicenter study and apply myocardial stiffness parameters to the diagnosis of HFpEF., conditionsModule conditions: Shear Wave Elastography, conditions: Heart Failure With Preserved Ejection Fraction, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 800, type: ESTIMATED, armsInterventionsModule interventions name: Transthoracic echocardiography, outcomesModule primaryOutcomes measure: Shear wave velocity, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06282809, orgStudyIdInfo id: CSP3325, briefTitle: The HistoSonics Edison™ System for Treatment of Pancreatic Adenocarcinoma Using Histotripsy, acronym: GANNON, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06, primaryCompletionDateStruct date: 2025-07, completionDateStruct date: 2026-01, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-04-11, sponsorCollaboratorsModule leadSponsor name: HistoSonics, Inc., class: INDUSTRY, descriptionModule briefSummary: The purpose of this trial is to evaluate the safety of the HistoSonics Edison System for the destruction of pancreatic adenocarcinomas using histotripsy., conditionsModule conditions: Pancreas Cancer, conditions: Adenocarcinoma of the Pancreas, conditions: Pancreatic Cancer, conditions: Tumor of Pancreas, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: Prospective multi-center, single-arm, feasibility trial., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: HistoSonics Edison™ System for the treatment of pancreatic adenocarcinoma using histotripsy, outcomesModule primaryOutcomes measure: Evaluate the safety of the HistoSonics Edison System for the destruction of pancreatic adenocarcinomas using histotripsy, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hospital de la Santa Creu i Sant Pau, city: Barcelona, country: Spain, geoPoint lat: 41.38879, lon: 2.15899, hasResults: False
protocolSection identificationModule nctId: NCT06282796, orgStudyIdInfo id: EPW-CABC-01, briefTitle: Early Prediction and Warning for Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2026-12-31, completionDateStruct date: 2028-12-31, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: First Hospital of China Medical University, class: OTHER, descriptionModule briefSummary: This multicenter clinical study aims to build an intelligent and accurate diagnosis and dynamic prediction and early warning model of cardiotoxicity due to anthracycline-based breast cancer chemotherapy, clarify the value of the early warning model in guiding the targeted prevention of myocardial protection, providing an important theoretical basis for reducing the mortality rate of breast cancer and improving the prognosis., conditionsModule conditions: Breast Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 600, type: ESTIMATED, armsInterventionsModule interventions name: Echocardiography, outcomesModule primaryOutcomes measure: Left ventricular ejection fraction(unit: %) in all breast cancer patients treated with anthracycline-based chemotherapy., secondaryOutcomes measure: Left ventricular global longitudinal strain (unit: %) in all breast cancer patients treated with anthracycline-based chemotherapy., eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Fujian Cancer Hospital, status: RECRUITING, city: Fuzhou, state: Fujian, country: China, contacts name: Weiqin Huang, role: CONTACT, geoPoint lat: 26.06139, lon: 119.30611, locations facility: Dalian Friendship Hospital, status: RECRUITING, city: Dalian, state: Liaoning, country: China, contacts name: Bo Zhang, role: CONTACT, geoPoint lat: 38.91222, lon: 121.60222, locations facility: Dalian Municipal Central Hospital, status: RECRUITING, city: Dalian, state: Liaoning, country: China, contacts name: Qingxiong Yue, role: CONTACT, geoPoint lat: 38.91222, lon: 121.60222, locations facility: Liaoning Cancer Hospital & Institute, status: RECRUITING, city: Shenyang, state: Liaoning, country: China, contacts name: Xiaoxue Zhang, role: CONTACT, geoPoint lat: 41.79222, lon: 123.43278, locations facility: The Third People's Hospital Of Chengdu, status: RECRUITING, city: Chengdu, state: Sichuan, country: China, contacts name: Min Xu, role: CONTACT, geoPoint lat: 30.66667, lon: 104.06667, hasResults: False