protocolSection identificationModule nctId: NCT06343233, orgStudyIdInfo id: FATE, briefTitle: FAiling HearT in the Elderly (FATE) Study, acronym: FATE, statusModule overallStatus: RECRUITING, startDateStruct date: 2019-11-19, primaryCompletionDateStruct date: 2024-12, completionDateStruct date: 2024-12, studyFirstPostDateStruct date: 2024-04-02, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: IRCCS Multimedica, class: OTHER, descriptionModule briefSummary: In 2015 the Italian Ministry of Health invited the Cardiac Research Hospitals of Italy to constitute a Cardiac Network. The aim of the network is to facilitate and promote scientific and technological research in the setting of cardiovascular diseases and related risk factors. The Cardiology Network, responding to the indications of the National Health Research Program, which includes research models oriented towards prevention studies with objectives and priority areas of intervention such as "acquiring scientific knowledge necessary for implementing both secondary and tertiary prevention programs for patients and primary prevention for contacts, where indicated, or for subjects exposed to specific risk factors", aims to identify strategies and/or prognostic and predictive factors of outcomes through the construction of thoroughly studied case series and systematic collection of biological materials, as well as the definition of research models based on clinical outcomes.The Study aims to examine the impact of clinical practice and therapies, analytically considering treatments and other important covariates that contribute in a complex manner to the therapeutic success of patients with heart failure., conditionsModule conditions: Heart Failure, conditions: Frailty, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 5000, type: ESTIMATED, armsInterventionsModule interventions name: usual care, outcomesModule primaryOutcomes measure: Hospitalization or death at 12 months, secondaryOutcomes measure: Hospitalization or death at 6-12-18 months, secondaryOutcomes measure: hospitalizations and/or death from cardiovascular causes, secondaryOutcomes measure: association between events and patient characteristics, eligibilityModule sex: ALL, minimumAge: 65 Years, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Istituti clinici scientifici Maugeri - IRCCS Montescano ( Cardiologia DPT), status: RECRUITING, city: Montescano, state: Italy/Pavia, zip: 27040, country: Italy, contacts name: Maria Teresa La Rovere, MD, role: CONTACT, phone: +39 0385 247290, email: mariateresa.larovere@icsmaugeri.it, geoPoint lat: 45.03196, lon: 9.28366, locations facility: IRCCS Centro Cardiologico Monzino, status: RECRUITING, city: Milan, state: MIlano, zip: 20138, country: Italy, contacts name: PierGiuseppe Agostoni, MD, role: CONTACT, phone: +39 02 58002772, email: piergiuseppe.agostoni@unimi.it, geoPoint lat: 45.46427, lon: 9.18951, locations facility: IRCCS Humanitas Research Hospital, status: RECRUITING, city: Rozzano, state: Milano, zip: 20089, country: Italy, contacts name: Cristina Panico, MD, role: CONTACT, phone: +39 0282241, email: cristina.panico@humanitas.it, geoPoint lat: 45.38193, lon: 9.1559, locations facility: IRCCS MultiMedica, status: RECRUITING, city: Sesto San Giovanni, state: Milano, zip: 20099, country: Italy, contacts name: Gaia Cattadori, MD, role: CONTACT, phone: +39 02 8687 8889, email: gaia.cattadori@multimedica.it, geoPoint lat: 45.53329, lon: 9.22585, locations facility: Ospedale Policlinico San Martino IRCCS, status: RECRUITING, city: Genova, zip: 16132, country: Italy, contacts name: Pietro Ameri, MD, role: CONTACT, phone: +39 0103538928, email: pietroameri@unige.it, geoPoint lat: 44.40478, lon: 8.94438, locations facility: IRCCS Auxologico, status: RECRUITING, city: Milano, zip: 20149, country: Italy, contacts name: Gianluca Caldara, MD, role: CONTACT, phone: +39 02 61911 251, email: g.caldara@auxologico.it, geoPoint lat: 45.46427, lon: 9.18951, locations facility: Fondazione IRCCS Ca'Granda - Ospedale Maggiore Policlinico, status: NOT_YET_RECRUITING, city: Milan, zip: 20100, country: Italy, contacts name: Marco Vicenzi, MD, role: CONTACT, phone: +39 02 503 20512, email: marco.vicenzi@unimi.it, geoPoint lat: 45.46427, lon: 9.18951, hasResults: False