hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06376123, orgStudyIdInfo id: Nkangarli001, briefTitle: Nomogram for Prediction of Alveolo-arterial Gradient During One-lung Ventilation, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2024-09-01, completionDateStruct date: 2024-09-15, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Bezmialem Vakif University, class: OTHER, descriptionModule briefSummary: The cause of hypoxia during one-lung ventilation is a common anaesthetic problem seen during thoracic surgery and is associated with increased fraction of shunted blood. This shunt occurs because the lung not participating in respiration stops saturating the blood with oxygen. The importance of our study is to collect some of the patient's parameters on a nomogram in the preoperative period, to predict the shunt fraction that will occur during one-lung ventilation and to make preparations and interventions accordingly., conditionsModule conditions: One-lung Ventilation, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: PROSPECTIVE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Alveolo-arterial gradient, primaryOutcomes measure: Alveolo-arterial gradient, secondaryOutcomes measure: Alveolo-arterial gradient change, secondaryOutcomes measure: Alveolo-arterial gradient change, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 100 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Bezmialem Vakif University Dragos Hospital, city: Istanbul, state: Maltepe, zip: 34844, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06376110, orgStudyIdInfo id: AviClear-001, briefTitle: Single-Blind Study Assessing the Use of a Topical Antioxidant With A Series of Laser Procedures to Reduce Sebum Production, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-15, primaryCompletionDateStruct date: 2025-04-15, completionDateStruct date: 2025-04-15, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Austin Institute for Clinical Research, class: NETWORK, collaborators name: SkinCeuticals, descriptionModule briefSummary: This is a split-face, single-blind study assessing the use of an antioxidant serum with a series of acne laser treatments to reduce sebum production in healthy male and female subjects between the ages of 18 and 65 years, inclusive, with Fitzpatrick skin types I-VI., conditionsModule conditions: Acne, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: SEQUENTIAL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: Topical Antioxidant Serum, interventions name: AviClear Laser, outcomesModule primaryOutcomes measure: Change in Product Tolerability, primaryOutcomes measure: Change in Product Efficacy, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06376097, orgStudyIdInfo id: D5162R00036, briefTitle: Lung Cancer Screening Program Using Low-dose Tomography and Metabolomic Evaluation in a Public Service., statusModule overallStatus: RECRUITING, startDateStruct date: 2023-04-19, primaryCompletionDateStruct date: 2025-01-30, completionDateStruct date: 2025-01-30, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: AstraZeneca, class: INDUSTRY, descriptionModule briefSummary: Observational study that aims to evaluate the implementation of a lung cancer screening program in a smoker population included in a public heath service., conditionsModule conditions: Lung Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 1000, type: ESTIMATED, outcomesModule primaryOutcomes measure: Absolute number and frequency of false-negative lung nodules ., secondaryOutcomes measure: Assess adherence to smoking cessation treatment in active smokers who enter screening., secondaryOutcomes measure: Assessment of morbidity and mortality in patients undergoing invasive procedures, whether diagnostic or therapeutic., secondaryOutcomes measure: Cost comparasion of treating patients in metastatic setting vs. treating early-stage lung cancer patients, including all costs from the screening program., eligibilityModule sex: ALL, minimumAge: 45 Years, maximumAge: 74 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hospital das Clínicas da Faculdade de Medicina de Botucatu (HCFMB), status: RECRUITING, city: Botucatu, state: São Paulo, zip: 18618-686, country: Brazil, contacts name: Erica Hasimoto, role: CONTACT, phone: (14) 99792-0222, email: ericanh80@hotmail.com, geoPoint lat: -22.88583, lon: -48.445, hasResults: False
protocolSection identificationModule nctId: NCT06376084, orgStudyIdInfo id: D5161R00055, briefTitle: Osimertinib With Chemotherapy as First-line Therapy for EGFR Mutation-positive NSCLC, acronym: FOREFRONT, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-07-24, primaryCompletionDateStruct date: 2028-02-28, completionDateStruct date: 2028-02-28, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: AstraZeneca, class: INDUSTRY, descriptionModule briefSummary: To estimate parameters related to clinical outcomes in a real-world seeting, including investigator reported PFS and OS., conditionsModule conditions: Carcinoma, Non-Small-Cell Lung, conditions: Lung Neoplasms, conditions: Respiratory Tract Neoplasms, conditions: Thoracic Neoplasms, conditions: Neoplasms by Site, conditions: Neoplasms, conditions: Lung Diseases, conditions: Respiratory Tract Diseases, conditions: Carcinoma, Bronchogenic, conditions: Bronchial Neoplasms, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: PROSPECTIVE, enrollmentInfo count: 700, type: ESTIMATED, outcomesModule primaryOutcomes measure: Real-World Progression Free Survival (rwPFS), secondaryOutcomes measure: Chemotherapy regimen, secondaryOutcomes measure: Duration of chemotherapy (induction and maintenance cycles), secondaryOutcomes measure: Response rate, secondaryOutcomes measure: Duration of response, secondaryOutcomes measure: Overall survival (OS), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Shanghai Chest Hospital, city: Shanghai, state: Shanghai, zip: 200030, country: China, contacts name: Rong LI, role: CONTACT, phone: +8621-22200000-5451, email: lrw@hotmail.com, geoPoint lat: 31.22222, lon: 121.45806, hasResults: False
protocolSection identificationModule nctId: NCT06376071, orgStudyIdInfo id: fungal rhinosiusitis, briefTitle: Sinonasal Risk Factors for Occurrence of Unilateral Versus Bilateral Allergic Fungal Rhinosinusitis ., statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-05-01, completionDateStruct date: 2025-06-30, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: This study aims to assess Sinonasal risk factors for occurrence of unilateral versus bilateral allergic fungal rhino sinusitis regarding::1. anatomical variations and correlate radiological finding with intraoperative finding.2. other associated factors like demographic ,environmental, immunological and climatic risk factors ., conditionsModule conditions: Allergic Fungal Rhinosinusitis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CROSSOVER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 76, type: ESTIMATED, armsInterventionsModule interventions name: functional endoscopic sinus surgery, outcomesModule primaryOutcomes measure: Sinonasal risk factors for occurrence of unilateral versus bilateral allergic fungal rhinosinusitis, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06376045, orgStudyIdInfo id: 20220093, briefTitle: A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-10, primaryCompletionDateStruct date: 2026-08-10, completionDateStruct date: 2026-10-02, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Amgen, class: INDUSTRY, descriptionModule briefSummary: The primary objective of this study is to describe the efficacy of rocatinlimab in reducing asthma exacerbations., conditionsModule conditions: Asthma, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 428, type: ESTIMATED, armsInterventionsModule interventions name: Rocatinlimab, interventions name: Placebo, outcomesModule primaryOutcomes measure: Annualized Asthma Exacerbation Rate (AAER) During the Blinded Treatment Period, secondaryOutcomes measure: Change From Baseline in Pre-bronchodilator (BD) Forced Expiratory Volume in 1 Second (FEV1), secondaryOutcomes measure: Annualized Rate of Composite Endpoint for Exacerbations (CompEx) Events During the Blinded Treatment Period, secondaryOutcomes measure: Change From Baseline in Asthma Control Questionnaire 6 (ACQ-6) Score at Week 48, secondaryOutcomes measure: Change From Baseline in Pre-BD FEV1, secondaryOutcomes measure: Change From Baseline in Asthma Symptom Diary (ASD) Score, secondaryOutcomes measure: Number of Participant Achieving ACQ-6 Response at Week 48, secondaryOutcomes measure: Change From Baseline in ACQ-6, secondaryOutcomes measure: Change From Baseline in Asthma Quality of Life Questionnaire with Standardized Activities (AQLQ (S)) Self-Administered Score, secondaryOutcomes measure: Number of Participants Achieving AQLQ (S) Response at Week 48, secondaryOutcomes measure: Annualized Rate of Asthma Exacerbation Leading to Hospitalization or Emergency Room Visits During the Blinded Treatment Period, secondaryOutcomes measure: Time to First Asthma Exacerbation Event, secondaryOutcomes measure: Time to First CompEx Event, secondaryOutcomes measure: Number of Participants with a CompEx Event During the Double Blinded Treatment Period, secondaryOutcomes measure: Annualized Rate of CompEx Events, secondaryOutcomes measure: Change From Baseline in Fractional Exhaled Nitric Oxide (FeNO) Levels, secondaryOutcomes measure: Serum Rocatinlimab Concentrations, secondaryOutcomes measure: Trough Concentration (Ctrough) of Rocatinlimab, secondaryOutcomes measure: Number of Participants with Treatment-emergent Adverse Events, secondaryOutcomes measure: Number of Participants with Serious Adverse Events, secondaryOutcomes measure: Number of Participants with Anti-rocatinlimab Antibody Formation, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06376019, orgStudyIdInfo id: FDASU-RecID11352, briefTitle: Occlusion and Disocclusion Time in Immediately Loaded Overdentures Supported by Two Splinted Versus Non Splinted Interforaminal Implants, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-25, primaryCompletionDateStruct date: 2024-08-15, completionDateStruct date: 2024-09-15, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Ain Shams University, class: OTHER, descriptionModule briefSummary: complete denture wearers struggle to eat well with their dentures due to poor denture retention, stability, and occlusal disharmony. So, the current study protocol aims to compare the occlusion/ disocclusion time in immediately loaded implant retained overdentures supported by two interforaminal implants; splinted versus non splinted dental implants compared to the conventional complete denture., conditionsModule conditions: Edentulous Jaw, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: parallel assignment of the participants in ratio 1:1:1 will take place. For allocation concealment, opaque sealed envelopes will be used., primaryPurpose: TREATMENT, maskingInfo masking: NONE, maskingDescription: the statistician will be the only one to be blinded, enrollmentInfo count: 27, type: ESTIMATED, armsInterventionsModule interventions name: solitary Implant loading with ball attachment, interventions name: splinted Implant loading with intra oral welding, interventions name: complete denture, outcomesModule primaryOutcomes measure: Assessment of occlusion/disocclusion time, eligibilityModule sex: ALL, minimumAge: 50 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Faculty of Dentistry Ain Shams University, city: Cairo, zip: 11361, country: Egypt, geoPoint lat: 30.06263, lon: 31.24967, hasResults: False
protocolSection identificationModule nctId: NCT06376006, orgStudyIdInfo id: 1798538, briefTitle: Evaluating Learning Curves and Competence in Colorectal Endoscopic Mucosal Resection Among Advanced Endoscopy Trainees, acronym: EMR-STAT, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2022-05-11, primaryCompletionDateStruct date: 2024-04-01, completionDateStruct date: 2024-12-01, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-24, sponsorCollaboratorsModule leadSponsor name: AdventHealth, class: OTHER, collaborators name: Duke University, collaborators name: University of South Florida, collaborators name: Stony Brook University, collaborators name: Atrium Medical Center, collaborators name: Hofstra University, collaborators name: Long Island Jewish Medical Center, collaborators name: Vanderbilt University, collaborators name: Yale University, collaborators name: Columbia University, collaborators name: Geisinger Clinic, collaborators name: Unity Health Toronto, collaborators name: University of Virginia, collaborators name: Baylor University, collaborators name: University of Kentucky, collaborators name: Cedars-Sinai Medical Center, collaborators name: University of Chicago, collaborators name: University of California, Irvine, collaborators name: University of Alabama at Birmingham, collaborators name: Beth Israel Deaconess Medical Center, descriptionModule briefSummary: Quality improvement project with the aim to use a standardized assessment tool (EMR-STAT) to establish learning curves and competence thresholds for key cognitive and technical colorectal EMR core skills among advanced endoscopy trainees (AETs)., conditionsModule conditions: Competence, conditions: Assessment, Self, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 42, type: ESTIMATED, armsInterventionsModule interventions name: EMR STAT - Survey, outcomesModule primaryOutcomes measure: Primary Endpoint, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: AdventHealth Orlando, city: Orlando, state: Florida, zip: 32804, country: United States, geoPoint lat: 28.53834, lon: -81.37924, hasResults: False
protocolSection identificationModule nctId: NCT06375993, orgStudyIdInfo id: ADI-202300103, briefTitle: A Phase 1 Study of ADI-001 in Lupus Nephritis, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06, primaryCompletionDateStruct date: 2026-12, completionDateStruct date: 2027-12, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Adicet Bio, Inc, class: INDUSTRY, descriptionModule briefSummary: ADI-202300103 is a phase 1 multicenter, open label, dose finding and dose expansion safety/efficacy study in patients with lupus nephritis. The study will consist of different periods including screening, lymphodepletion, treatment, and follow-up, conditionsModule conditions: Lupus Nephritis, conditions: Autoimmune Diseases, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NON_RANDOMIZED, interventionModel: SEQUENTIAL, interventionModelDescription: 3+3 Dose Escalation Design, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: ADI-001, interventions name: Fludarabine, interventions name: Cyclophosphamide, outcomesModule primaryOutcomes measure: The Incidence of Subjects with Dose Limiting Toxicities within each dose level cohort, primaryOutcomes measure: Proportion of treatment emergent and treatment related adverse events, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06375980, orgStudyIdInfo id: ANKARA_OR_MP, briefTitle: Intraoperative Mechanical Power and Ventilation-Associated Lung Injury: Assessing Complications, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-04-01, primaryCompletionDateStruct date: 2022-12-31, completionDateStruct date: 2022-12-31, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, class: OTHER, descriptionModule briefSummary: This study investigates the relationship between intraoperative mechanical power and postoperative pulmonary complications in patients undergoing major abdominal surgery. We record mechanical ventilation parameters and surgical characteristics, assessing the incidence of pulmonary complications within 24 hours postoperatively, conditionsModule conditions: Lung Injury, conditions: Pulmonary Complication, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 207, type: ACTUAL, armsInterventionsModule interventions name: Intraoperative Mechanical Ventilation Strategies, outcomesModule primaryOutcomes measure: Relationship between mechanical power and postoperative pulmonary complications, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Ankara Oncology Training and Research Hospital, city: Ankara, zip: 06200, country: Turkey, geoPoint lat: 39.91987, lon: 32.85427, hasResults: False
protocolSection identificationModule nctId: NCT06375941, orgStudyIdInfo id: ProStars, briefTitle: Prospective Observational Study of Localized Angiosarcoma of Any Site: ProStars, acronym: ProStars, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-29, primaryCompletionDateStruct date: 2029-04-01, completionDateStruct date: 2034-04-01, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: Italian Sarcoma Group, class: NETWORK, descriptionModule briefSummary: This study will be a multi-institutional, prospective, observational study of patients with localized primary AS of any site within ISG and RTR centers. Patients will be treated according to clinical practice of the center and according to ISG clinical recommendations on localized AS., conditionsModule conditions: Angiosarcoma, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 250, type: ESTIMATED, armsInterventionsModule interventions name: Observational, outcomesModule primaryOutcomes measure: Demographic characteristics, primaryOutcomes measure: General characteristics, primaryOutcomes measure: Cancer data, primaryOutcomes measure: Origin of Tumor, primaryOutcomes measure: Tumor characteristics, primaryOutcomes measure: Tumor size, primaryOutcomes measure: Tumor aspects, primaryOutcomes measure: Pathological characteristics, primaryOutcomes measure: Tumor phenotype, primaryOutcomes measure: Molecular characteristics, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: IRCCS Istituto Nazionale Tumori - Milano, status: RECRUITING, city: Milano, zip: 20133, country: Italy, contacts name: Palassini Elena, role: CONTACT, geoPoint lat: 45.46427, lon: 9.18951, hasResults: False
protocolSection identificationModule nctId: NCT06375902, orgStudyIdInfo id: 2022289RNA, briefTitle: The Fragility of Metaphors (FraMe): Learning, Loosing, and How to Train Them, acronym: FRAME, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2025-10, completionDateStruct date: 2025-10, studyFirstPostDateStruct date: 2024-04-19, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: IRCCS San Raffaele, class: OTHER, descriptionModule briefSummary: Tracking down the difficulties in metaphor comprehension experienced by individuals with schizophrenia across different metaphor types and exploring the neurological correlates via EEG recording technique, conditionsModule conditions: Schizophrenia; Psychosis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 64, type: ESTIMATED, armsInterventionsModule interventions name: PragmaCom, outcomesModule primaryOutcomes measure: Tracking down the difficulties in metaphor comprehension via a behavioural task, primaryOutcomes measure: Tracking down the difficulties in metaphor comprehension via task during electrophysiological recording, secondaryOutcomes measure: Evaluation of psychopathology, secondaryOutcomes measure: Evaluation of cognition, secondaryOutcomes measure: Evaluation of Theory of Mind, secondaryOutcomes measure: Evaluation of functioning, secondaryOutcomes measure: Evaluate the efficacy of a rehabilitative training in restoring metaphor comprehension ability, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False