hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06334367, orgStudyIdInfo id: SWYX:NO.2022-1028, briefTitle: Prophylaxis of Graft-versus-host Disease With Anti-CD25 Antibody in Patients Underwent HSCT, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-26, primaryCompletionDateStruct date: 2026-03-26, completionDateStruct date: 2026-03-26, studyFirstPostDateStruct date: 2024-03-28, lastUpdatePostDateStruct date: 2024-03-28, sponsorCollaboratorsModule leadSponsor name: Wang Xin, class: OTHER_GOV, descriptionModule briefSummary: The risk of Graft-versus-host Disease(GVHD) is significantly associated with the mortality rate of patients undergoing allogeneic hematopoietic stem cell transplantation. The occurrence of GVHD increases the hospitalization rate and economic burden of patients. In order to explore better methods for controlling GVHD, we designed a clinical trial using CD25 monoclonal antibody for GVHD prevention. Our previous studies have shown that reduced-dose anti-thymocyte globulin(ATG) in the conditioning regimen can achieve the same effect as full-dose ATG. Here, we try to explore the preventive effect of CD25 antibody on acute and chronic GHVD under low-dose ATG pretreatment condition., conditionsModule conditions: GVHD, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: CD25 treatment, interventions name: low-dose ATG, outcomesModule primaryOutcomes measure: The incidence of aGVHD, primaryOutcomes measure: The incidence of cGVHD, secondaryOutcomes measure: the time of immune reconstitution in haploidentical transplant, secondaryOutcomes measure: the time of infection occurrence, secondaryOutcomes measure: the time of donor cell engraftment, secondaryOutcomes measure: the time of disease relapse, secondaryOutcomes measure: the time of death of transplant patient, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, city: Jinan, state: Shandong, zip: 250021, country: China, contacts name: Xin Wang, MD, PHD, role: CONTACT, phone: 86-531-68778331, email: xinw007@126.com, contacts name: Xiaosheng Fang, MD, PHD, role: CONTACT, phone: 8615168889703, email: fxsh_1010@126.com, geoPoint lat: 36.66833, lon: 116.99722, hasResults: False
protocolSection identificationModule nctId: NCT06334328, orgStudyIdInfo id: 2205009237, briefTitle: Virtual Reality-based Mindful Movement Therapy for Seniors, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-08-15, primaryCompletionDateStruct date: 2023-09-30, completionDateStruct date: 2024-01-31, studyFirstPostDateStruct date: 2024-03-28, lastUpdatePostDateStruct date: 2024-03-28, sponsorCollaboratorsModule leadSponsor name: Drexel University, class: OTHER, descriptionModule briefSummary: The current proposal aims to 1) develop a technical platform and implementation plan for the delivery of a virtual reality-based mindful movement therapy (VR-MMT) protocol for older adults; and 2) conduct a clinical trial to examine the feasibility and preliminary efficacy of an 8-week, 16-session module VR-MMT intervention for this population. The findings of this study will help us to identify engagement barriers and refine the intervention contents as well as the study protocol necessary for the preparation of grant applications to conduct a controlled clinical trial. This study is innovative and high impact as this is the first study to examine the feasibility and preliminary efficacy of a VR-MMT intervention that could potentially ameliorate cognitive and mobility decline and promote psychological wellbeing in older adults by combining a widely accessible technology and creative embodiment-based approach., conditionsModule conditions: Cognitive Decline, conditions: Physical Activity, conditions: Psychological Wellbeing, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 12, type: ACTUAL, armsInterventionsModule interventions name: Virtual reality based mindful movement therapy, outcomesModule primaryOutcomes measure: Treatment adherence, primaryOutcomes measure: Treatment acceptability, primaryOutcomes measure: Treatment satisfaction, primaryOutcomes measure: Qualitative feedback, primaryOutcomes measure: Safety, secondaryOutcomes measure: Montreal Cognitive Assessment (MoCA), secondaryOutcomes measure: Trail making test, secondaryOutcomes measure: The Warwick-Edinburgh Mental Well-being Scale (WEMWBS), secondaryOutcomes measure: Physical Activity Scale for the Elderly (PASE), secondaryOutcomes measure: Physical Performance Battery (SPPB), secondaryOutcomes measure: General Self-Efficacy Scale, secondaryOutcomes measure: Positive Affect and Negative Affect Scale (PANAS), eligibilityModule sex: ALL, minimumAge: 65 Years, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Drexel Universitsy, city: Philadelphia, state: Pennsylvania, zip: 19102, country: United States, geoPoint lat: 39.95233, lon: -75.16379, hasResults: False
protocolSection identificationModule nctId: NCT06334289, orgStudyIdInfo id: YXLL-KY-2024(017), briefTitle: A Predictive Study of Peripheral Blood Biomarkers on Postoperative Neurocognitive Dysfunction in Elderly Frail and Non-frail Patients Undergoing Gastrointestinal Surgery, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-03-28, lastUpdatePostDateStruct date: 2024-03-28, sponsorCollaboratorsModule leadSponsor name: Qianfoshan Hospital, class: OTHER, descriptionModule briefSummary: Perioperative neurocognitive impairment (PND) mainly includes acute postoperative delirium (POD) and persistent postoperative cognitive impairment (POCD), which are common postoperative complications in elderly patients. Perioperative neurocognitive impairment (PND) is attracting increasing attention, but its exact mechanism is still unclear. The diagnosis of PND lacks the gold standard, so it is difficult to determine the incidence rate. At present, the diagnosis is mainly conducted through the scale. Therefore, this study aims to explore the correlation between peripheral blood biomarkers and PND in elderly frail patients undergoing gastrointestinal surgery., conditionsModule conditions: Perioperative Neurocognitive Disorders, conditions: Frail Elderly, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 338, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Postoperative 7-day incidence of PND, eligibilityModule sex: ALL, minimumAge: 65 Years, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06334276, orgStudyIdInfo id: DROWN_INHOS, briefTitle: Developing an Utstein-style Danish Drowning Registry: Nationwide Fatal and Nonfatal Drowning Data Since 2016, acronym: DROWN_INHOS, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2025-01-01, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-03-28, lastUpdatePostDateStruct date: 2024-03-28, sponsorCollaboratorsModule leadSponsor name: Prehospital Center, Region Zealand, class: OTHER, descriptionModule briefSummary: This nationwide, registry-based study aims to link Danish Prehospital Drowning Data data with inhospital data to develop a Utstein-style Danish Drowning Registry. This study will report mortality and neurological outcomes 30 days after a drowning incident since 2016., conditionsModule conditions: Drowning, conditions: Drowning, Near, conditions: Drowning; Asphyxia, conditions: Drowning and Nonfatal Submersion, conditions: Drowning or Immersion of Unknown Intent, conditions: Drowning and Submersion, Undetermined Intent, conditions: Drowning and Submersion While in Bath-Tub, conditions: Drowning and Submersion While in Natural Water, conditions: Drowning and Submersion While in Swimming-Pool, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 1500, type: ESTIMATED, armsInterventionsModule interventions name: Drowning, outcomesModule primaryOutcomes measure: 30-day mortality, primaryOutcomes measure: Neurological outcome, secondaryOutcomes measure: Hospital length of stay, secondaryOutcomes measure: Intensive care unit admission, secondaryOutcomes measure: Intensive care unit length of stay, secondaryOutcomes measure: Need for mechanical ventilation, secondaryOutcomes measure: Duration of mechanical ventilation, secondaryOutcomes measure: Survival to hospital discharge, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Prehospital Center, city: Næstved, state: Region Zealand, zip: 4700, country: Denmark, geoPoint lat: 55.22992, lon: 11.76092, hasResults: False
protocolSection identificationModule nctId: NCT06334263, orgStudyIdInfo id: 332302, briefTitle: Splenic Embolisation Decisions, acronym: SPEED, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2024-09-30, completionDateStruct date: 2025-09-30, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: University Hospital Plymouth NHS Trust, class: OTHER, descriptionModule briefSummary: The spleen is often injured when the body sustains trauma. This leads to bleeding. The bleeding can be stopped by a big operation cutting open the belly or a small hole in your groin where a blood vessel can be accessed and through which the bleeding can be stopped. We do not know what types of injuries it is best to use this procedure. We do not know why we do not use the smaller technique in some instances. We also do not know exactly which of a number of ways to stop the bleeding could be better. We have a big data set in the trauma and audit research network (TARN) which we would like to use to help answer these questions and design further studies to better answer the questions. Adding a few other pieces of data, we are able to answer key questions into how the spleen will best be treated in trauma., conditionsModule conditions: Trauma, conditions: Spleen Injury, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: OTHER, enrollmentInfo count: 8000, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: To determine if service design significantly affects splenic embolisation (SE) rates in AAST grade 2-5 acute traumatic splenic injuries (ATSI) across the 22 Major Trauma Centres (MTCs) in the UK., primaryOutcomes measure: To determine if variation in treatment affects SE outcomes in ATSI, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06334237, orgStudyIdInfo id: Y_113_0009, briefTitle: Psychosomatic Factors Influencing the Efficacy of Holistic Care for Migraine, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-15, primaryCompletionDateStruct date: 2025-02-21, completionDateStruct date: 2026-02-21, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: Changhua Christian Hospital, class: OTHER, descriptionModule briefSummary: This research project aims at exploring the psychosomatic factors that influence and moderate the efficacy of holistic care and personalized treatment for migraine patients. It is a prospective longitudinal observational study. The project's goal is to understand how physical, psychological, spiritual, and social factors affect the care and treatment outcomes for migraineurs. The study will include participants aged 18 to 65, who meet the International Headache Society's criteria for migraines. It will utilize a range of methodologies including questionnaires, interviews, and medical records to collect data on various factors like lifestyle, psychological state, and social support. The project will assess the effectiveness of treatments, compliance, and other outcomes such as emotional and sleep conditions., conditionsModule conditions: Migraine, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 120, type: ESTIMATED, armsInterventionsModule interventions name: personalized treatment, outcomesModule primaryOutcomes measure: Migraine attack frequency, primaryOutcomes measure: Migraine attack intensity, primaryOutcomes measure: Migraine attack duration, primaryOutcomes measure: Effectiveness of acute medication, secondaryOutcomes measure: Compliance rate of migraine diary, secondaryOutcomes measure: Compliance rate of lifestyle modification, secondaryOutcomes measure: depression, secondaryOutcomes measure: anxiety, secondaryOutcomes measure: well-being, secondaryOutcomes measure: Pain Resilience, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Changhua Christian Hospital, city: Chang Hua, zip: 500, country: Taiwan, contacts name: Yen-Yu Chen, MD, role: CONTACT, phone: +886-4-7238595, email: 107281@cch.org.tw, geoPoint lat: 24.07327, lon: 120.56276, hasResults: False
protocolSection identificationModule nctId: NCT06334198, orgStudyIdInfo id: Naldemedine_OIBD, secondaryIdInfos id: 2023-507744-36-00, type: CTIS, briefTitle: The Effect of Naldemedine on Opioid-induced Bowel Dysfunction, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-12, primaryCompletionDateStruct date: 2025-03, completionDateStruct date: 2025-03, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-03-28, sponsorCollaboratorsModule leadSponsor name: Asbjørn Mohr Drewes, class: OTHER, descriptionModule briefSummary: Opioid-induced bowel dysfunction is a frequent condition during opioid therapy for chronic pain. Indeed, up to 90% of people on opioid treated patients experience constipation. Standard laxative treatment is often ineffective in opioid-induced constipation, but peripheral acting mu-receptor antagonists (PAMORAs) have the potential to block the effects of opioids in the gastrointestinal tract while preserving the central analgesic effect. In this study, we will investigated the effects of Naldemedine in preventing the development of opioid-induced bowel dysfunction and constipation during treatment with tramadol, conditionsModule conditions: Opioid-Induced Bowel Dysfunction, conditions: Constipation, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Naldemedine, interventions name: Placebo, interventions name: Tramadol, outcomesModule primaryOutcomes measure: Total gastrointestinal transit time, primaryOutcomes measure: Colorectal transit time, secondaryOutcomes measure: Constipation symptoms, secondaryOutcomes measure: Bowel movement frequency, secondaryOutcomes measure: Stool consistency, secondaryOutcomes measure: Gastrointestinal symptoms, secondaryOutcomes measure: Opioid-induced constipation, secondaryOutcomes measure: Diagnostic evaluation of opioid-induced constipation, secondaryOutcomes measure: Colonic motility patterns, secondaryOutcomes measure: Opiate withdrawal symptoms, secondaryOutcomes measure: Colon volume, secondaryOutcomes measure: Colonic water content, secondaryOutcomes measure: Defecation assessment, eligibilityModule sex: MALE, minimumAge: 20 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule locations facility: Aalborg University Hospital, status: RECRUITING, city: Aalborg, zip: 9000, country: Denmark, contacts name: Asbjørn Mohr Drewes, role: CONTACT, geoPoint lat: 57.048, lon: 9.9187, hasResults: False
protocolSection identificationModule nctId: NCT06334185, orgStudyIdInfo id: pVax, briefTitle: Evaluation of Vaccination for Streptococcus Pneumoniae in Adults With an Episode of Invasive Pneumococcal Infection., acronym: pVax, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2024-07-01, completionDateStruct date: 2024-07-01, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-03-28, sponsorCollaboratorsModule leadSponsor name: Azienda Ospedaliera di Lecco, class: OTHER, collaborators name: IRCCS Ospedale San Raffaele, descriptionModule briefSummary: Respiratory tract infections are among the leading causes of death worldwide and many of these infections are preventable through vaccination. One of the most important bacteria from an etiological and mortality point of view regarding respiratory and systemic infections is the gram-positive Streptococcus pneumoniae. Four types of vaccines are currently available for this pathogen: three pneumococcal conjugate vaccines (PCV13, PCV15, and PCV20) and one polysaccharide vaccine (PPSV23). In Italy, people over 65 years of age and people suffering from chronic pathologies with effects on the immune system would be advised to be vaccinated with the pneumococcal conjugate vaccine and with the polysaccharide vaccine as a second dose.However, there are no data available in Italy on vaccination coverage in these population categories and above all the vaccination rates in patients who have a history of an episode of invasive pneumococcal infection are not known. The aim of the study is to measure how many patients are vaccinated for S. pneumoniae after hospitalization for a systemic pneumococcal infection in order to understand patients' awareness of preventing this infection after receiving a first diagnosis., conditionsModule conditions: Invasive Pneumococcal Infection, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 320, type: ESTIMATED, outcomesModule primaryOutcomes measure: Rate of antipneumococcal vaccination in hospitalized patients for invasive pneumococcal infection between 2015 and 2019., secondaryOutcomes measure: Rate of pneumococcal serotype that caused the invasive infection in patients vaccinated prior to the infectious event, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06334172, orgStudyIdInfo id: H-23071221, briefTitle: The Role of Oxytocin in Regulating Blood Glucose, acronym: GLOXY-1, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2026-12-31, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-04-04, sponsorCollaboratorsModule leadSponsor name: University Hospital, Gentofte, Copenhagen, class: OTHER, descriptionModule briefSummary: Investigating the effect of oxytocin on pancreatic endocrine functions by determining insulin and glucagon secretion within physiological ranges of plasma glucose., conditionsModule conditions: Glucose Metabolism Disorders (Including Diabetes Mellitus), designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, interventionModelDescription: Randomized, double-blinded, single-arm study. Each participant goes through three experimental days in a randomized order - acting as their own controls, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: DOUBLE, maskingDescription: The randomized order of infusions is blinded to both participant and investigator, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Oxytocin, interventions name: Placebo, outcomesModule primaryOutcomes measure: Insulin secretion - c-peptide, secondaryOutcomes measure: Glucose, secondaryOutcomes measure: Insulin, secondaryOutcomes measure: Glucagon, secondaryOutcomes measure: GIP, secondaryOutcomes measure: GLP-1, secondaryOutcomes measure: Lipids, secondaryOutcomes measure: Cross-linked C-telopeptide of type I collagen( CTX), secondaryOutcomes measure: Procollagen type I N-terminal propeptide (P1NP), eligibilityModule sex: MALE, minimumAge: 20 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: Center for Clinical Metabolic Research, Gentofte Hospital, status: RECRUITING, city: Hellerup, state: Capital Region, zip: 2900, country: Denmark, contacts name: Filip K Knop, MD, PhD, role: CONTACT, phone: 004538674266, email: filip.krag.knop.01@regionh.dk, geoPoint lat: 55.73204, lon: 12.57093, hasResults: False
protocolSection identificationModule nctId: NCT06334159, orgStudyIdInfo id: PER-ECL-2019-08, briefTitle: Guided Bone Regeneration Using Fixed vs Non-Fixed Resorbable Collagen Membranes, statusModule overallStatus: RECRUITING, startDateStruct date: 2020-11-05, primaryCompletionDateStruct date: 2025-07-20, completionDateStruct date: 2027-07-20, studyFirstPostDateStruct date: 2024-03-27, lastUpdatePostDateStruct date: 2024-03-27, sponsorCollaboratorsModule leadSponsor name: Universitat Internacional de Catalunya, class: OTHER, descriptionModule briefSummary: The aim of this clinical trial is to compare the horizontal bone gain when grafting a bone substitute with non fixed resorbable collagen membranes (control group), versus fixed resorbable collagen membranes (test group) in resorbed ridges requiring Guided Bone Regeneration (GBR) to facilitate implant placement at 6 months., conditionsModule conditions: Bone Resorption, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: FACTORIAL, interventionModelDescription: non fixed resorbable collagen membranes (control group), versus fixed resorbable collagen membranes (test group), primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 26, type: ESTIMATED, armsInterventionsModule interventions name: Horizontal GBR with the use of non-resorbable pins for the stabilization of the collagen membrane, interventions name: Horizontal GBR without the use of non-resorbable pins for the stabilization of the collagen membrane, outcomesModule primaryOutcomes measure: Horizontal Bone Gain, primaryOutcomes measure: Bone Width Gain, secondaryOutcomes measure: Horizontal Dimensional Stability, secondaryOutcomes measure: Post-surgical complications, secondaryOutcomes measure: Patient's satisfaction, secondaryOutcomes measure: Histologic examination of the augmented bone at 6 months, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Georgios Markantonatos, status: RECRUITING, city: Barcelona, state: Sant Cugat Del Vallès, zip: 08195, country: Spain, contacts name: Georgios Markantonatos, DDS, role: CONTACT, phone: +34666022568, email: giorgosmark@uic.es, contacts name: Cristina Vallès, DDS, MS, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 41.38879, lon: 2.15899, hasResults: False