protocolSection identificationModule nctId: NCT06361121, orgStudyIdInfo id: D361, briefTitle: Mid-point Transverse Process to Pleura Block Versus Thoracic Paravertebral Block in Posterolateral Thoracotomy, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-03, completionDateStruct date: 2025-03, studyFirstPostDateStruct date: 2024-04-11, lastUpdatePostDateStruct date: 2024-04-11, sponsorCollaboratorsModule leadSponsor name: Fayoum University Hospital, class: OTHER, descriptionModule briefSummary: The ultrasound guided Thoracic paravertebral (TPV) block in the context of posterolateral thoracotomy offers targeted pain relief by anesthetizing the spinal nerves as they emerge from the intervertebral foramina, producing ipsilateral somatosensory, visceral and sympathetic nerve blockade. TPV block involves the injection of local anesthetic (LA) into the wedge-shaped paravertebral space deep to the superior costotransverse ligament (SCTL)Costach et al introduced the mid-point transverse process to pleura block (MTP) as a modification of conventional paravertebral block by placing the LA posterior to the (SCTL) under ultrasound guidence achieving an effective block without the necessity to approach the pleura and the attendant risks.In recent studies ,the ultrasound guided MTP block provided an effective analgesia in various surgical procedures including mastectomy, video-assisted thoracic surgeries and cardiac surgeries.In our study we hypothesized that the mid-point transverse process to pleura (MTP) block can provide an effective analgesia comparable with thoracic paravertebral (TPV) block in adult patients undergoing posterolateral thoracotomy incisions., conditionsModule conditions: Bronchiectasis, conditions: Lung Neoplasm, conditions: Emphysematous Bleb of Lung, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, maskingDescription: The patients will be randomized into two groups: MTP block group and TPV block group in a 1:1 ratio using a computer-generated random table. The patient's assigned group information will be elicited from a sealed opaque envelope by the anesthesiologist who will perform the US-guided MTP and TPV block and will not be involved in further data collection or patient care. The patients and both the surgical and anesthesia teams, who are responsible for patient care and data collection are blinded from the group assignments, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 180, type: ESTIMATED, armsInterventionsModule interventions name: mid-point transverse process to pleura (MTP) block, interventions name: Thoracic Paravertebral Block, outcomesModule primaryOutcomes measure: The total postoperative fentanyl consumption, secondaryOutcomes measure: Demographic data, secondaryOutcomes measure: visual analogue scale score both during rest and with cough, secondaryOutcomes measure: intra operative fentanyl consumption, secondaryOutcomes measure: Duration of surgery, secondaryOutcomes measure: Blood pressure, secondaryOutcomes measure: Heart rate, secondaryOutcomes measure: Oxygen saturation, secondaryOutcomes measure: complications related to the block, secondaryOutcomes measure: complications related to IV opioids, secondaryOutcomes measure: Hospital length of stay in days, secondaryOutcomes measure: Participant satisfaction, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Fayoum University Hospital, status: RECRUITING, city: Fayoum, zip: 63514, country: Egypt, contacts name: Mohamed A Hamed, MD, role: CONTACT, phone: 01010509736, phoneExt: +20, email: mah07@fayoum.edu.eg, contacts name: Mohamed A Hamed, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.30995, lon: 30.8418, hasResults: False