protocolSection identificationModule nctId: NCT06277037, orgStudyIdInfo id: AB-729-204, briefTitle: Long-Term Follow-up Study for Subjects With CHB Previously Treated With Imdusiran (AB729), statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-07-15, primaryCompletionDateStruct date: 2029-08-30, completionDateStruct date: 2029-10-30, studyFirstPostDateStruct date: 2024-02-26, lastUpdatePostDateStruct date: 2024-04-01, sponsorCollaboratorsModule leadSponsor name: Arbutus Biopharma Corporation, class: INDUSTRY, descriptionModule briefSummary: This is a long term follow-up study for chronic hepatitis B (CHB) subjects who have received imdusiran treatment in a prior clinical trial, stopped NA therapy during that trial, and remain off therapy. Subjects may enroll after completing the end of study visit (baseline visit within 12 weeks ± 1 week from the end of study \[EOS\] visit) from their imdusiran clinical trial (the "parent study"). No interventions will be performed in this study other than blood sample collections, review of current medications, and reporting of any adverse events related to study procedures or NA therapy if restarted. Study participation will be for approximately 2 years (to complete a total of at least 3 years of follow-up while off NA therapy, inclusive of parent study participation)., conditionsModule conditions: Long Term Follow-up, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: OTHER, enrollmentInfo count: 35, type: ESTIMATED, armsInterventionsModule interventions name: Non-interventional, outcomesModule primaryOutcomes measure: To evaluate the durability of effect of imdusiran on HBV parameters, primaryOutcomes measure: To evaluate the durability of effect of imdusiran on HBV parameters, primaryOutcomes measure: To evaluate the durability of effect of imdusiran on HBV parameters, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The Alfred Hospital, city: Melbourne, state: Victoria, zip: 3004, country: Australia, contacts name: Stuart Roberts, role: CONTACT, contacts role: CONTACT, email: S.Roberts@alfred.org.au, geoPoint lat: -37.814, lon: 144.96332, locations facility: Fiona Stanley Hospital, city: Murdoch, zip: 6150, country: Australia, contacts name: Sam Galhenage, role: CONTACT, geoPoint lat: -32.06987, lon: 115.83757, locations facility: Queen Mary Hospital, city: Hong Kong, country: Hong Kong, geoPoint lat: 22.27832, lon: 114.17469, locations facility: Prince of Wales Hospital, city: Shatin, country: Hong Kong, contacts name: Grace Wong, role: CONTACT, geoPoint lat: 22.38333, lon: 114.18333, locations facility: Changhua Christian Hospital, city: Changhua city, zip: 600566, country: Taiwan, geoPoint lat: 24.07327, lon: 120.56276, locations facility: Chia-Yi Christian Hospital, city: Chiayi City, zip: 60002, country: Taiwan, contacts name: Chi-Yi Chen, role: CONTACT, geoPoint lat: 23.47917, lon: 120.44889, locations facility: Kaohsiung Medical University Chung-Ho Memorial Hospital, city: Kaohsiung, zip: 80756, country: Taiwan, contacts name: Wan-Long Chuang, role: CONTACT, geoPoint lat: 22.61626, lon: 120.31333, locations facility: E-Da Hospital, city: Kaohsiung, zip: 82445, country: Taiwan, contacts name: Gin-Ho Lo, role: CONTACT, geoPoint lat: 22.61626, lon: 120.31333, locations facility: Taichung Veterans General Hospital, city: Taichung, zip: 40705, country: Taiwan, contacts name: Sheng-Shun Yang, role: CONTACT, geoPoint lat: 24.1469, lon: 120.6839, locations facility: Chang Gung Medical Foundation Linkou, city: Taoyuan, zip: 33305, country: Taiwan, contacts name: Chao-Wei Hsu, role: CONTACT, geoPoint lat: 24.95233, lon: 121.20193, locations facility: University Hospital of Wales, Cardiff, city: Cardiff, zip: CF144XW, country: United Kingdom, contacts name: Jonathan Underwood, role: CONTACT, geoPoint lat: 51.48, lon: -3.18, locations facility: Royal London Hospital, city: London, zip: E11FR, country: United Kingdom, geoPoint lat: 51.50853, lon: -0.12574, locations facility: King's College Hospital, city: London, zip: SE59RS, country: United Kingdom, contacts name: Kosh Agarwal, role: CONTACT, geoPoint lat: 51.50853, lon: -0.12574, hasResults: False