protocolSection identificationModule nctId: NCT06277466, orgStudyIdInfo id: XYFY2023-KL478-01, briefTitle: Effect of Mutations in T2DM Susceptibility Genes on the Expression of Susceptibility Genes in Patients With T2DM and Controls, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2028-01-31, completionDateStruct date: 2028-01-31, studyFirstPostDateStruct date: 2024-02-26, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: The Affiliated Hospital of Xuzhou Medical University, class: OTHER, descriptionModule briefSummary: In this study, investigators wanted to determine the effect of T2DM susceptibility gene mutations on self-expression.Participants (T2DM patients and controls) were recruited to identify genotypes and detect the levels of T2DM susceptibility genes expression in the fresh peripheral plasma. The normal pancreatic tissues or adjacent tissues of pancreatic cancer were also collected to identify the expression differences of T2DM susceptibility genes under different genotypes., conditionsModule conditions: Type 2 Diabetes Mellitus, conditions: Gene Polymorphisms, conditions: Genetic Mutations, conditions: Susceptibility, Genetic, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 300, type: ESTIMATED, armsInterventionsModule interventions name: Fresh normal pancreatic tissues or adjacent tissues of pancreatic cancer were collected from controls and T2DM patients without hypoglycemic drugs, interventions name: Fresh blood samples were collected from healthy subjects and T2DM patients without hypoglycemic drugs, outcomesModule primaryOutcomes measure: Detection of T2DM susceptibility gene expression in newly diagnosed T2DM patients, primaryOutcomes measure: Detection of T2DM susceptibility gene expression in controls, primaryOutcomes measure: Correlation between T2DM susceptibility gene expression and clinicopathological features, secondaryOutcomes measure: Baseline BMI of newly diagnosed with T2DM patients with different genotypes, secondaryOutcomes measure: Baseline waist hip ratio (WHR) of newly diagnosed with T2DM patients with different genotypes, secondaryOutcomes measure: Baseline fasting plasma glucose (FPG) of newly diagnosed with T2DM patients with different genotypes, secondaryOutcomes measure: Baseline HbA1c of newly diagnosed with T2DM patients with different genotypes, secondaryOutcomes measure: Baseline TC of newly diagnosed with T2DM patients with different genotypes, secondaryOutcomes measure: Baseline TG of newly diagnosed with T2DM patients with different genotypes, secondaryOutcomes measure: Baseline HDL-C of newly diagnosed with T2DM patients with different genotypes, secondaryOutcomes measure: Baseline LDL-C of newly diagnosed with T2DM patients with different genotypes, secondaryOutcomes measure: Baseline BMI of controls with different genotypes, secondaryOutcomes measure: Baseline WHR of controls with different genotypes, secondaryOutcomes measure: Baseline FPG of controls with different genotypes, secondaryOutcomes measure: Baseline HbA1c of controls with different genotypes, secondaryOutcomes measure: Baseline TC of controls with different genotypes, secondaryOutcomes measure: Baseline TG of controls with different genotypes, secondaryOutcomes measure: Baseline HDL-C of controls with different genotypes, secondaryOutcomes measure: Baseline LDL-C of controls with different genotypes, eligibilityModule sex: ALL, minimumAge: 25 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: China, Jiangsu, Department of Endocrinology, status: RECRUITING, city: Xuzhou, zip: 221006, country: China, contacts name: Hongwei Ling, MD, role: CONTACT, phone: 18052268607, email: linghongwei@medmail.com.cn, contacts name: Renguo Chen, MD, role: PRINCIPAL_INVESTIGATOR, contacts name: Yuhan Huang, MD, role: SUB_INVESTIGATOR, geoPoint lat: 34.18045, lon: 117.15707, hasResults: False