protocolSection identificationModule nctId: NCT06306625, orgStudyIdInfo id: 69HCL21_0001, secondaryIdInfos id: 2023-A01315-40, type: OTHER, domain: ID-RCB, briefTitle: REmote COnditioning in Out-of-Hospital Cardiac Arrest, acronym: RECO-OHCA, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2026-05-04, completionDateStruct date: 2026-08-15, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-03-13, sponsorCollaboratorsModule leadSponsor name: Hospices Civils de Lyon, class: OTHER, descriptionModule briefSummary: Out-of-Hospital Cardiac Arrest remains a major public health problem, resulting in high mortality largely related to multiple organ failure and poor neurological outcomes due to brain anoxia. The pathophysiology of organ dysfunction after resuscitated out-of-hospital cardiac arrest involves ischemia-reperfusion processes. Remote ischemic conditioning is a therapeutic strategy used to protect organs against the detrimental effects of ischemia-reperfusion injury.The objective of the present trial is to determine whether remote ischemic conditioning performed early after out-of-hospital cardiac arrest can decrease mortality, or multiple organ failure and/or severe neurological failure., conditionsModule conditions: Out-Of-Hospital Cardiac Arrest, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 220, type: ESTIMATED, armsInterventionsModule interventions name: Remote ischemic conditioning, interventions name: No remote ischemic conditioning, outcomesModule primaryOutcomes measure: All cause of death, primaryOutcomes measure: Multiple organ failure, primaryOutcomes measure: Severe neurological failure, secondaryOutcomes measure: Sepsis-related Organ Failure Assessment (SOFA) score, secondaryOutcomes measure: Sepsis-related Organ Failure Assessment (SOFA) score, secondaryOutcomes measure: Sepsis-related Organ Failure Assessment (SOFA) score, secondaryOutcomes measure: Sepsis-related Organ Failure Assessment (SOFA) score after exclusion of the neurological sub-score, secondaryOutcomes measure: Sepsis-related Organ Failure Assessment (SOFA) score after exclusion of the neurological sub-score, secondaryOutcomes measure: Sepsis-related Organ Failure Assessment (SOFA) score after exclusion of the neurological sub-score, secondaryOutcomes measure: Sepsis-related Organ Failure Assessment (SOFA) sub-scores for each organ dysfunction, secondaryOutcomes measure: Sepsis-related Organ Failure Assessment (SOFA) sub-scores for each organ dysfunction, secondaryOutcomes measure: Sepsis-related Organ Failure Assessment (SOFA) sub-scores for each organ dysfunction, secondaryOutcomes measure: Mean Sepsis-related Organ Failure Assessment (SOFA) score, secondaryOutcomes measure: Mean Sepsis-related Organ Failure Assessment (SOFA) score after exclusion of the neurological sub-score, secondaryOutcomes measure: Variations of the Sepsis-related Organ Failure Assessment (SOFA) score (delta-SOFA), secondaryOutcomes measure: Variations of the Sepsis-related Organ Failure Assessment (SOFA) score (delta-SOFA) after exclusion of the neurological sub-score, secondaryOutcomes measure: Serum level of neuron-specific enolase (NSE), secondaryOutcomes measure: Cerebral Performance Categories (CPC) scale, secondaryOutcomes measure: All-cause mortality, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hôpital Louis Pradel, city: Bron, zip: 69500, country: France, contacts name: Thomas BOCHATON, role: CONTACT, phone: 04 72 35 75 41, phoneExt: +33, email: thomas.bochaton@chu-lyon.fr, contacts name: Thomas BOCHATON, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.73333, lon: 4.91667, locations facility: Hôpital Gabriel Montpied, CHU de Clermont Ferrand, city: Clermont-Ferrand, zip: 63000, country: France, contacts name: François THOUY, role: CONTACT, phone: 04 73 75 07 50, phoneExt: +33, email: fthouy@chu-clermontferrand.fr, contacts name: François THOUY, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.77966, lon: 3.08628, locations facility: Centre Jean Perrin, Clermont-Ferrand, city: Clermont-Ferrand, zip: 69300, country: France, contacts name: Alexandre LAUTRETTE, role: CONTACT, phone: 04 73 27 80 80, phoneExt: +33, email: alautrette@chu-clermontferrand.fr, contacts name: Alexandre LAUTRETTE, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.77966, lon: 3.08628, locations facility: Hôpital F Mitterrand, CHU de Dijon, city: Dijon, zip: 21079, country: France, contacts name: Jean-Pierre QUENOT, role: CONTACT, phone: 03 80 29 37 51, phoneExt: +33, email: jean-pierre.quenot@chu-dijon.fr, contacts name: Jean-Pierre QUENOT, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 47.31667, lon: 5.01667, locations facility: Hôpital Albert Michallon, CHU de Grenoble, city: La Tronche, zip: 38700, country: France, contacts name: Carole SCHWEBEL, role: CONTACT, phone: 04 76 76 87 79, phoneExt: +33, email: cschwebel@chu-grenoble.fr, contacts name: Carole SCHWEBEL, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.20429, lon: 5.73645, locations facility: Hôpital Edouard Herriot, city: Lyon, zip: 69003, country: France, contacts name: Marie-Line HARLAY, role: CONTACT, phone: 04 72 11 28 62, phoneExt: +33, email: marie-line.harlay@chu-lyon.fr, contacts name: Laurent ARGAUD, role: CONTACT, phone: 04 72 11 28 62, phoneExt: +33, email: laurent.argaud@chu-lyon.fr, contacts name: Marie-Line HARLAY, role: PRINCIPAL_INVESTIGATOR, contacts name: Laurent ARGAUD, role: SUB_INVESTIGATOR, contacts name: Martin COUR, role: SUB_INVESTIGATOR, geoPoint lat: 45.74848, lon: 4.84669, locations facility: Hôpital Saint-Joseph Saint-Luc, city: Lyon, zip: 69007, country: France, contacts name: Emmanuel VIVIER, role: CONTACT, phone: 04 78 61 82 09, phoneExt: +33, email: evivier@ch-stjosephstluc-lyon.fr, contacts name: Emmanuel VIVIER, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.74848, lon: 4.84669, locations facility: Hôpital de la Timone, CHU de Marseille, city: Marseille, zip: 13385, country: France, contacts name: Marc GAINNIER, role: CONTACT, phone: 04 91 38 85 50, phoneExt: +33, email: marc.gainnier@ap-hm.fr, contacts name: Marc GAINNIER, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.29551, lon: 5.38958, locations facility: Hôpital lapeyronie, CHU de Montpellier, city: Montpellier, zip: 34295, country: France, contacts name: Kada KLOUCHE, role: CONTACT, phone: 04 67 33 77 36, phoneExt: +33, email: k-klouche@chu-montpellier.fr, contacts name: Kada KLOUCHE, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.61092, lon: 3.87723, locations facility: Hôpital Universitaire Carémeau, city: Nîmes, zip: 30029, country: France, contacts name: Claire ROGER, role: CONTACT, phone: 04 66 68 33 31, phoneExt: +33, email: claire.roger@chu-nimes.fr, contacts name: Claire ROGER, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.83333, lon: 4.35, locations facility: Hôpital Lyon-Sud, city: Pierre-Bénite, zip: 69310, country: France, contacts name: Auguste DARGENT, role: CONTACT, phone: 04 78 86 21 18, phoneExt: +33, email: auguste.dargent@chu-lyon.fr, contacts name: Auguste DARGENT, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.7009, lon: 4.82511, locations facility: Hôpital Nord, CHU de St Etienne, city: Saint-Priest-en-Jarez, zip: 42270, country: France, contacts name: Guillaume THIERY, role: CONTACT, phone: 04 77 12 78 62, phoneExt: +33, email: guillaume.thiery@chu-st-etienne.fr, contacts name: Guillaume THIERY, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.47501, lon: 4.37614, locations facility: Hôpital Nord-Ouest, city: Villefranche-sur-Saône, zip: 69655, country: France, contacts name: Julien ILLINGER, role: CONTACT, phone: 04 74 09 29 31, phoneExt: +33, email: jillinger@hno.fr, contacts name: Julien ILLINGER, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 45.98333, lon: 4.71667, hasResults: False