protocolSection identificationModule nctId: NCT06282341, orgStudyIdInfo id: 23CH132, briefTitle: Fatigue and Recovery: a Comparison Between Trail and Marathon, acronym: MARA-TRAIL, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-28, primaryCompletionDateStruct date: 2025-08, completionDateStruct date: 2025-09, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Centre Hospitalier Universitaire de Saint Etienne, class: OTHER, descriptionModule briefSummary: Road marathon is a famous running race known for hundreds of years. Trail running is an emerging running discipline which count new runners every year. Trail running and road marathon are two running endurance disciplines which differed by variation of elevation and nature of the terrain. While marathon is essentially run on flat roads, trail races are realized on steep paths (mountain, desert...) with an important variation of elevation. Neuromuscular, biomechanical and physiological consequences are different depending on the discipline, especially with a greater eccentric contribution in trail running. In spite of this characteristic, trail runners take part in several races longer than 40 km per year, while road runners participate in one to two marathons per year., conditionsModule conditions: Healthy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Prospective study on healthy volunteers, comparing the neurophysiological, physiological and biomechanical effects at the end of a marathon compared with an equivalent effort trail in the open air, or simulated on a treadmill, in runners specialising in each of the 2 disciplines, primaryPurpose: SCREENING, maskingInfo masking: NONE, enrollmentInfo count: 90, type: ESTIMATED, armsInterventionsModule interventions name: Race: Simulated marathon, interventions name: Race: Simulated trail, interventions name: Race: Trail in nature, outcomesModule primaryOutcomes measure: Change in knee extensors maximal isometric torque output, secondaryOutcomes measure: Change in plantar flexor maximal isometric torque output, secondaryOutcomes measure: Recovery of quadriceps maximal isometric torque output the month after the race, secondaryOutcomes measure: Voluntary activation level, secondaryOutcomes measure: Force assessed in dynamic, secondaryOutcomes measure: Velocity assessed in dynamic, secondaryOutcomes measure: Power assessed in dynamic, secondaryOutcomes measure: Muscular power and stretch-shortening cycle assessed through squat jumps, secondaryOutcomes measure: Muscular power and stretch-shortening cycle assessed through countermovement jump, secondaryOutcomes measure: Muscular power and stretch-shortening cycle assessed through drop jump, secondaryOutcomes measure: Muscle electrical activity, secondaryOutcomes measure: The kinetics of energy cost, secondaryOutcomes measure: Racing kinematics, secondaryOutcomes measure: Ground reaction force (in Newton), secondaryOutcomes measure: Center of pressure (in Newton), secondaryOutcomes measure: Muscle damage blood markers, secondaryOutcomes measure: Resting heart rate variability parameters, secondaryOutcomes measure: Effort perception, secondaryOutcomes measure: fatigue assessment, secondaryOutcomes measure: Muscular pain, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: Unités de Myologie et de Médecine du Sport, status: RECRUITING, city: Saint-Étienne, zip: 42055, country: France, contacts name: Léonard FEASSON, Phd, role: CONTACT, phone: 04 77 12 03 83, email: leonard.feasson@chu-st-etienne.fr, contacts name: Diana RIMAUD, role: CONTACT, email: diana.rimaud@chu-st-etienne.fr, contacts name: Clément FOSCHIA, Dr, role: SUB_INVESTIGATOR, contacts name: Pascal EDOUARD, Dr, role: SUB_INVESTIGATOR, geoPoint lat: 45.43389, lon: 4.39, hasResults: False