protocolSection identificationModule nctId: NCT06389734, orgStudyIdInfo id: B-ER-111-470, briefTitle: Combining Manual Soft Tissue Release and Exercise Training in COPD: the Effect on LF, EC, and CAF, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-03-02, primaryCompletionDateStruct date: 2024-02-02, completionDateStruct date: 2024-02-02, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: National Cheng Kung University, class: OTHER, descriptionModule briefSummary: The potential effects of combining manual soft tissue release and physical exercise training on lung function, exercise capacity, and cardiac autonomic function in patients with moderate and severe chronic obstructive pulmonary disease were investigated., conditionsModule conditions: Chronic Obstructive Pulmonary Disease, conditions: Manual Soft Tissue Release, conditions: Exercise Training, conditions: Lung Function, conditions: Exercise Capacity, conditions: Cardiac Autonomic Function, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: The study population will be randomized and separated in two groups, experimental and control group., primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 70, type: ACTUAL, armsInterventionsModule interventions name: Manual soft tissue release, interventions name: Myofascial release, interventions name: Exercise training, outcomesModule primaryOutcomes measure: Forced expiratory volume in 1 s (FEV1), primaryOutcomes measure: forced vital capacity (FVC), primaryOutcomes measure: FEV1/FVC ratio, primaryOutcomes measure: expiratory reserve volume (ERV), primaryOutcomes measure: functional residual capacity (FRC), primaryOutcomes measure: inspiratory capacity (IC), primaryOutcomes measure: inspiratory reserve volume (IRV),, primaryOutcomes measure: residual volume (RV), primaryOutcomes measure: total lung capacity (TLC), primaryOutcomes measure: tidal volume (TV), primaryOutcomes measure: vital capacity (VC), secondaryOutcomes measure: Rate of perceived exertion (RPE), secondaryOutcomes measure: Oxygen consumption (VO2), secondaryOutcomes measure: oxygen saturation, secondaryOutcomes measure: heart rate (HR), secondaryOutcomes measure: blood pressure (BP), secondaryOutcomes measure: Diaphragmatic mobility, secondaryOutcomes measure: Cardiac Autonomic Function, secondaryOutcomes measure: six minute walk test (6-MWT), secondaryOutcomes measure: maximal expiratory pressure (MEP), secondaryOutcomes measure: maximal inspiratory pressure (MIP), secondaryOutcomes measure: St. George's Respiratory Questionnaire (SGRQ), secondaryOutcomes measure: fatigue severity scale (FSS), secondaryOutcomes measure: Modified Medical Research Council (mMRC), secondaryOutcomes measure: 36-Item Short Form Health Survey (SF-36), eligibilityModule sex: ALL, minimumAge: 30 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: National Cheng Kung University, city: Tainan, zip: 701, country: Taiwan, geoPoint lat: 22.99083, lon: 120.21333, hasResults: False