hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06293651, orgStudyIdInfo id: DA4505_AMST_I/IIa, briefTitle: Clinical Trial to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of DA-4505 as a Single Agent and in Combination With Pembrolizumab in Adult Patients With Locally Advanced or Metastatic Solid Tumors, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2025-11, completionDateStruct date: 2030-04, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Dong-A ST Co., Ltd., class: INDUSTRY, descriptionModule briefSummary: This study is an Open-Label, Phase 1/2a, First-in-Human, Dose-Escalation, Dose-Expansion, and Proof-of-Concept Study to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of DA-4505 as a Single Agent and in Combination With Pembrolizumab in Adult Patients With Locally Advanced or Metastatic Solid Tumors., conditionsModule conditions: Locally Advanced or Metastatic Solid Tumors, designModule studyType: INTERVENTIONAL, phases: PHASE1, phases: PHASE2, designInfo allocation: NON_RANDOMIZED, interventionModel: SEQUENTIAL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 125, type: ESTIMATED, armsInterventionsModule interventions name: DA-4505, interventions name: DA-4505 + Pembrolizumab, outcomesModule primaryOutcomes measure: Proportion of adverse events (AEs) meeting protocol-defined dose-limiting toxicity(DLT) criteria, primaryOutcomes measure: PK parameters for DA-4505 (Peak Plasma Concentration (Cmax)), primaryOutcomes measure: PK parameters for DA-4505 (Area Under the Curve (AUC)), primaryOutcomes measure: PK parameters for DA-4505 (half-life (t1/2)), primaryOutcomes measure: Response per revised "Response Evaluation Criteria in Solid Tumors (RECIST) version (v) 1.1), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06293638, orgStudyIdInfo id: 23-1125, briefTitle: Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor, acronym: TRaNCE, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-25, primaryCompletionDateStruct date: 2026-12-31, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-04-02, sponsorCollaboratorsModule leadSponsor name: The Cleveland Clinic, class: OTHER, descriptionModule briefSummary: The purpose of this study is to collect electrophysiological data related to functional brain network changes in patients undergoing deep brain stimulation for the treatment of essential tremor. Participants will be asked to remain seated with their head inside of a Magnetoencephalography (MEG) recording system as resting-state and task-related data are acquired. Spontaneous electrophysiological activity will be recorded in both the eyes open and eyes closed conditions with the participant seated comfortably. These recordings will be repeated in the DBS OFF and DBS ON states, with the ON state involving specific settings identified as optimal, sub-optimal, or ineffective at achieving tremor control. They will also be repeated following the optional administration non-DBS tremor mitigation techniques, which may include one or more of 1) cooling the limb, 2) oral administration of alprazolam, 3) oral consumption of ethanol (alcohol), or 4) peripheral nerve stimulation., conditionsModule conditions: Essential Tremor, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 45, type: ESTIMATED, armsInterventionsModule interventions name: Alcohol, interventions name: Alprazolam, interventions name: Cold Therapy, interventions name: Peripheral Nerve Stimulation, outcomesModule primaryOutcomes measure: CTCM Coherence, primaryOutcomes measure: Power of oscillatory activity across the CTCM network in response to tremor interventions, secondaryOutcomes measure: Essential tremor severity: Tremor Research Group Essential Tremor Rating Scale (TETRAS), secondaryOutcomes measure: Essential tremor severity: Grip force, secondaryOutcomes measure: Essential tremor severity: Limb acceleration, eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Cleveland Clinic, status: RECRUITING, city: Cleveland, state: Ohio, zip: 44195, country: United States, contacts name: Jeff Negrey, MA, role: CONTACT, phone: 216-636-5504, email: negreyj2@ccf.org, contacts name: James Liao, MD, role: PRINCIPAL_INVESTIGATOR, contacts name: Ken baker, PhD, role: SUB_INVESTIGATOR, geoPoint lat: 41.4995, lon: -81.69541, hasResults: False
protocolSection identificationModule nctId: NCT06293625, orgStudyIdInfo id: LEPAGE PHRCK 2022-2, briefTitle: Personalising and Refining Neo-adjuvant Chemotherapy in Locally Advanced But Resecable Colon Cancer in the Elderly of 70 Years Old or More, acronym: FOxTROT2France, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2032-03, completionDateStruct date: 2032-03, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Centre Hospitalier Universitaire Dijon, class: OTHER, descriptionModule briefSummary: Colon cancer (CC) is the 5th most common cancer worldwide. Standard care for locally advanced disease is surgical resection followed by 3-6 months of adjuvant chemotherapy (AC) with oxaliplatin and 5-fluorouracil (OxFp).Almost all of these patients undergo surgery, but many do not receive AC due to frailty (following surgery). This particularly affects patients over 70, who represent the majority of patients diagnosed with CC.FOxTROT 2, a trial to test the role of NAC in older patients., conditionsModule conditions: Colon Cancer, designModule studyType: INTERVENTIONAL, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 150, type: ESTIMATED, armsInterventionsModule interventions name: Folfox, interventions name: Surgery, outcomesModule primaryOutcomes measure: DFS (disease Free Survival), eligibilityModule sex: ALL, minimumAge: 70 Years, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: CHU Dijon Bourgogne, city: Dijon, zip: 21000, country: France, contacts name: Côme LEPAGE, role: CONTACT, email: come.lepage@u-bourgogne.fr, geoPoint lat: 47.31667, lon: 5.01667, hasResults: False
protocolSection identificationModule nctId: NCT06293612, orgStudyIdInfo id: 22/449-3651, secondaryIdInfos id: 2022-I2M-C&T-B-077, type: OTHER_GRANT, domain: CAMS Innovation Fund for Medical Sciences (CIFMS), secondaryIdInfos id: 7244398, type: OTHER_GRANT, domain: Youth program of Beijing Natural Science Foundation, secondaryIdInfos id: Beijing Hope Run Special Fund, type: OTHER_GRANT, domain: LC2021A12, briefTitle: Constructing a Multimodal Imaging System to Predict the Risk of Heterochronous Metastasis of Rectal Cancer, acronym: MIS-MRC, statusModule overallStatus: COMPLETED, startDateStruct date: 2015-01-01, primaryCompletionDateStruct date: 2018-12-31, completionDateStruct date: 2022-11-30, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Cancer Institute and Hospital, Chinese Academy of Medical Sciences, class: OTHER, descriptionModule briefSummary: The goal of this observational study is to construct a multimodal intelligent model to predict the risk of heterochronous metastasis of rectal cancer, which is helpful for individualized diagnosis and treatment and follow-up planning. The main questions it aims to answer are:* what are the independent risk factors of distant metastasis (DM) in locally advanced rectal cancer (LARC)* What is the influence weight of the above factors on the heterochronous metastasis of LARC, and how to build a risk-prediction modelThis study will not affect or interfere with the routine medical diagnosis and treatment of participants, and will not increase the cost and risk of participants. Participant's information is protected and identified by a unique code., conditionsModule conditions: Locally Advanced Rectal Cancer, conditions: Distant Metastasis, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 302, type: ACTUAL, armsInterventionsModule interventions name: No intervention was administrated to the two cohorts., outcomesModule primaryOutcomes measure: Heterochronous distant metastasis, secondaryOutcomes measure: Distant metastasis-free survival, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, city: Beijing, zip: 100021, country: China, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False
protocolSection identificationModule nctId: NCT06293599, orgStudyIdInfo id: P.T.REC/012/003131, briefTitle: Effect of Scapular Stabilization Exercises Versus Virtual Reality Exercises in Basketball Players With Scapular Dyskinesia, acronym: SD, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-05, primaryCompletionDateStruct date: 2024-07-30, completionDateStruct date: 2024-07-30, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Cairo University, class: OTHER, descriptionModule briefSummary: this study will be conducted to compare virtual reality and scapular stabilizing exercise among basketball player with scapular dyskinesia on scapular muscle performance, rounded shoulder, pain intensity, disability and hand grip strength, conditionsModule conditions: Scapular Dyskinesis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: scapular stabilization and virtual reality exercise, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: opaque sealed envelope, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 90, type: ESTIMATED, armsInterventionsModule interventions name: scapular stabilization exercises, interventions name: virtual reality exercises, interventions name: regular routine exercises, outcomesModule primaryOutcomes measure: agonist antagonist ratio, secondaryOutcomes measure: Hand grip strength, secondaryOutcomes measure: rounded shoulder posture, secondaryOutcomes measure: pain intensity level, secondaryOutcomes measure: The disabilities of the arm, shoulder and hand, secondaryOutcomes measure: peak force, secondaryOutcomes measure: total work, secondaryOutcomes measure: work fatigue, secondaryOutcomes measure: average power, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 25 Years, stdAges: ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06293586, orgStudyIdInfo id: MD-11-2022, briefTitle: Comparison Between Peribulbar And Sub-tenon Blocks on Oculocardiac Reflex (OCR) During Pediatric Strabismus Surgery, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-12-01, primaryCompletionDateStruct date: 2024-03-30, completionDateStruct date: 2024-03-30, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Cairo University, class: OTHER, descriptionModule briefSummary: The aim of this study is to compare between peribulbar block and subtenon block as an adjunct to general anesthesia in children undergoing strabismus surgery on oculocardiac reflex (OCR), post-operative analgesia and postoperative vomiting. Both techniques will be compared to intra-operative intravenous (IV) paracetamol combined with general anesthesia as a sole anesthetic technique., conditionsModule conditions: Anesthesia, Local, conditions: Ophthalmopathy, conditions: Strabismus, conditions: Pediatric ALL, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 140, type: ESTIMATED, armsInterventionsModule interventions name: peribulbar block, interventions name: sub-tenon block, interventions name: Paracetamol, outcomesModule primaryOutcomes measure: The incidence of intraoperative oculocardiac reflex (OCR), secondaryOutcomes measure: blood pressure, secondaryOutcomes measure: heart rate, otherOutcomes measure: Post-operative pain using the MOPS, otherOutcomes measure: Post-operative analgesia requirements, otherOutcomes measure: The incidence of POV using numeric scoring, otherOutcomes measure: Complications resulting from orbital regional anesthesia were recorded, otherOutcomes measure: Total intraoperative atropine requirements, eligibilityModule sex: ALL, minimumAge: 6 Years, maximumAge: 13 Years, stdAges: CHILD, contactsLocationsModule locations facility: Cairo University faculty of medicine, status: RECRUITING, city: Cairo, zip: 11559, country: Egypt, contacts name: Essam Nossair, Masters degree, role: CONTACT, phone: 0201002014809, email: e.nossair92@gmail.com, geoPoint lat: 30.06263, lon: 31.24967, hasResults: False
protocolSection identificationModule nctId: NCT06293573, orgStudyIdInfo id: 012/005031, briefTitle: Whole- Body Vibration Among Egyptian Elderly With Sarcopenia, acronym: WBV, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2025-11-29, completionDateStruct date: 2025-12-01, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Cairo University, class: OTHER, descriptionModule briefSummary: To investigate and compare between the effectiveness of whole body vibration and aerobic training exercises in management of sarcopenia, muscle mass, physical performance and muscle strength in elderly., conditionsModule conditions: Sarcopenia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, maskingDescription: Participants will be assigned randomly into three groups of equal number (study group A, study group B, and group C) the randomization will be performed by computerized randomization. Assessors will be blinded to the groups of the subjects., whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 84, type: ESTIMATED, armsInterventionsModule interventions name: Whole-body vibration, interventions name: aerobic exercises, interventions name: resistance exercises, outcomesModule primaryOutcomes measure: Muscle Mass, primaryOutcomes measure: muscle strength, primaryOutcomes measure: timed Up and Go Test (TUG), primaryOutcomes measure: Gait Speed test, primaryOutcomes measure: 400 m Walking Test, primaryOutcomes measure: Six minute walk test (6MWT), eligibilityModule sex: ALL, minimumAge: 60 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Faculty of Physical Therapy, city: Dokki, state: Giza, zip: 12612, country: Egypt, geoPoint lat: 30.03823, lon: 31.2113, hasResults: False
protocolSection identificationModule nctId: NCT06293560, orgStudyIdInfo id: H-49046, secondaryIdInfos id: 5U01EY032403-03, type: NIH, link: https://reporter.nih.gov/quickSearch/5U01EY032403-03, briefTitle: Microphthalmia, Anophthalmia, and Coloboma Genetic Epidemiology in Children, acronym: MAGIC, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-09-25, primaryCompletionDateStruct date: 2027-09, completionDateStruct date: 2027-09, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Baylor College of Medicine, class: OTHER, collaborators name: National Eye Institute (NEI), collaborators name: National Institutes of Health (NIH), descriptionModule briefSummary: The investigators are inviting families to take part in a research study that will help us better understand the physical characteristics associated with children who have Microphthalmia, Anophthalmia, and Coloboma (MAC) and how changes in their DNA sequence, called genetic mutations, play a role in the risk of developing MAC, conditionsModule conditions: Microphthalmia, conditions: Coloboma, conditions: Anophthalmia, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 3000, type: ESTIMATED, outcomesModule primaryOutcomes measure: Stage 1, primaryOutcomes measure: Stage 2, primaryOutcomes measure: Stage 3, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Baylor College of Medicine, status: RECRUITING, city: Houston, state: Texas, zip: 77030, country: United States, contacts name: EpiCenter, role: CONTACT, phone: 713-798-2920, email: epicenter@bcm.edu, contacts name: Philip Lupo, PhD, MPH, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.76328, lon: -95.36327, hasResults: False
protocolSection identificationModule nctId: NCT06293534, orgStudyIdInfo id: PsychThyroid, briefTitle: Thyroid Dysfunction in Patients With Major Psychiatric Disorders, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-01-01, completionDateStruct date: 2025-02-01, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: Thyroid dysfunction in major psychiatric disorders in psychiatric patients admitted to psychiatric unit of assiut university hospital, conditionsModule conditions: Thyroid Dysfunction, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 173, type: ESTIMATED, armsInterventionsModule interventions name: TSH,T3,T4, outcomesModule primaryOutcomes measure: the level of thyroid hormones among psychiatric patients, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06293521, orgStudyIdInfo id: 06091995, briefTitle: Clinical and Radiographic Success Rate of Pulpotomy Versus Pulpectomy for Management of Primary Teeth With Deep Caries, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-16, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2025-01-01, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Cairo University, class: OTHER, descriptionModule briefSummary: This trial aims to compare treatment outcomes between Pulpotomy and Pulpectomy in treating vital primary teeth diagnosed with deep caries with symptoms of irreversible pulpits, conditionsModule conditions: Deep Caries, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Pulpotomy, interventions name: Partial Pulpectomy, outcomesModule primaryOutcomes measure: Radiographic assessment, secondaryOutcomes measure: Clinical effectiveness, secondaryOutcomes measure: Child cooperation, secondaryOutcomes measure: Time elapsed till final restoration performed, eligibilityModule sex: ALL, minimumAge: 4 Years, maximumAge: 6 Years, stdAges: CHILD, contactsLocationsModule locations facility: Cairo University, city: Cairo, country: Egypt, geoPoint lat: 30.06263, lon: 31.24967, hasResults: False
protocolSection identificationModule nctId: NCT06293495, orgStudyIdInfo id: CUT-OUT, briefTitle: Incidence of Cut-out Using Intramedullary Nails With Double Cephalic Screw vs. Unique in Pertrochanteric Fractures, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-09-30, completionDateStruct date: 2026-04-01, studyFirstPostDateStruct date: 2024-03-05, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Puerta de Hierro University Hospital, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to compare outcomes in the treatment of proximal femur fractures. The main question it aims to answer is whether the use of a double cephalic screw prevents nail failure (cut-out).Participants will be treated using open reduction and internal fixation with a proximal femoral nail. Researchers will compare intramedullary nailing with a single cephalic screw (Gamma nail) and with a double cephalic screw (Chimaera nail) to see the cut-out rate., conditionsModule conditions: Proximal Femoral Fractures, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized, prospective trial with a CE-marked medical devices, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 200, type: ESTIMATED, armsInterventionsModule interventions name: Gamma 3 Nail (Stryker), interventions name: Chimaera Nail (Orthofix), outcomesModule primaryOutcomes measure: Incidence of cut-out., secondaryOutcomes measure: Functional Ambulatory Categories (FAC), secondaryOutcomes measure: Tip-apex distance, secondaryOutcomes measure: Parker index, secondaryOutcomes measure: Baumgaertner reduction quality criteria, secondaryOutcomes measure: Number of Surgical complications (Intraoperative), secondaryOutcomes measure: Number of Surgical complications (post-operative), eligibilityModule sex: ALL, minimumAge: 70 Years, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hospital Universitario Puerta de Hierro Majadahonda, city: Majadahonda, state: Madrid, zip: 28222, country: Spain, geoPoint lat: 40.47353, lon: -3.87182, hasResults: False