protocolSection identificationModule nctId: NCT06279663, orgStudyIdInfo id: NSTE-ACS Multivessel Trial, briefTitle: Management Tactics for Patients High Risk With Acute Coronary Syndrome Without ST Segment Elevation and Multivessel Coronary Artery Disease, acronym: NSTE-ACSMT, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-29, primaryCompletionDateStruct date: 2028-12-31, completionDateStruct date: 2029-12-31, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-03-13, sponsorCollaboratorsModule leadSponsor name: Federal State Budgetary Institution National Medical Research Center named after academician E.N. Me, class: OTHER_GOV, collaborators name: Kemerovo Cardiology Center, Tarasov Roman Sergeevich, collaborators name: Tomsk National Research Medical Center of the Russian Academy of Sciences, Ryabov Vyacheslav Valeryevich, descriptionModule briefSummary: The study will include patients with acute coronary syndrome without ST segment elevation and multivessel CA lesion, who are subject to surgical treatment according to KG data (Syntax Score 23 - 32 points with significant damage to the anterior descending artery and/or trunk of the left coronary artery). The patient should be suitable for both CABG and PCI (confirmed by an X-ray surgeon and a cardiac surgeon). An X-ray surgeon and a cardiac surgeon, within the framework of planning the volume of revascularization, strives for the fullest feasible volume. Complete myocardial revascularization (that is, the desire for the absence of hemodynamically significant coronary arteries after revascularization, with a diameter of \> 2.5 mm, that is, residual coronary artery stenosis of no more than 60%). Thus, patients will be randomized into groups in a ratio of 1:1. Each group will need to include 230 patients (a total of 460). In the main group, revascularization will be performed by PCI, in the control group by CABG., conditionsModule conditions: Coronary Syndrome, Acute, Non-ST Elevation, High Risk Patients, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 460, type: ESTIMATED, armsInterventionsModule interventions name: Revascularization, outcomesModule primaryOutcomes measure: Death from any cause, primaryOutcomes measure: Combined endpoint (death from cardiovascular causes, MI, Stroke, repeated unplanned myocardial revascularization), primaryOutcomes measure: target LDL level, secondaryOutcomes measure: Myocardial infarction, secondaryOutcomes measure: Stroke, secondaryOutcomes measure: Repeated unplanned myocardial revascularization, secondaryOutcomes measure: Duration of the hospital period, secondaryOutcomes measure: Intra/perioperative complications, secondaryOutcomes measure: Significant hemorrhagic complications (grade 3 or more on the BARC scale), secondaryOutcomes measure: Questionnaire, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Anton, status: RECRUITING, city: Novosibirsk, state: Novosibirsk Obl, zip: 630055, country: Russian Federation, contacts name: Anton Obedinskiy, 1, role: CONTACT, phone: +73833476099, phoneExt: 1, email: a_obedinskij@meshalkin.ru, geoPoint lat: 55.0415, lon: 82.9346, locations facility: Anton, status: RECRUITING, city: Novosibirsk, state: Rechkunovskaya Str., zip: 630055, country: Russian Federation, contacts name: Anton Obedinskiy, role: CONTACT, phone: 89139322885, email: a_obedinskij@meshalkin.ru, geoPoint lat: 55.0415, lon: 82.9346, hasResults: False