hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06377904, orgStudyIdInfo id: 2023-A02125-40, briefTitle: Clinical and Therapeutic Characteristics of Geriatric Patients Hospitalized for Heart Failure (AGING HF Study (AGe and Heart Failure IN Geriatrics)), acronym: AGING HF, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2027-04, completionDateStruct date: 2028-04, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: Gérond'if, class: OTHER, descriptionModule briefSummary: This retrospective (between April 2020 and December 2023) then prospective (between January 2024 and August 2026), non-interventional cohort study has as its main objective to evaluate the clinical and therapeutic characteristics of patients aged 75 and over hospitalized in geriatrics for heart failure and also to evaluate the clinical characteristics and triggering factor(s) of acute heart failure., conditionsModule conditions: Patients Hospitalized in Geriatrics for Heart Failure, conditions: Patients Aged 75 and Over, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: OTHER, enrollmentInfo count: 810, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Evaluate the clinical and therapeutic characteristics of elderly patients hospitalized in geriatrics for heart failure, secondaryOutcomes measure: Factors associated with patients hospitalization or rehospitalization, eligibilityModule sex: ALL, minimumAge: 75 Years, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06377878, orgStudyIdInfo id: Pro00008369, briefTitle: The Preeclampsia Registry, acronym: TPR, statusModule overallStatus: RECRUITING, startDateStruct date: 2013-09-01, primaryCompletionDateStruct date: 2040-05, completionDateStruct date: 2040-05, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: Preeclampsia Foundation, class: OTHER, descriptionModule briefSummary: The purpose of The Preeclampsia Registry is to collect and store medical and other information from women who have been medically diagnosed with preeclampsia or a related hypertensive (high blood pressure) disorder of pregnancy such as eclampsia or HELLP syndrome, their family members, and women who have not had preeclampsia to serve as controls. Information from participants will be used for medical research to try to understand why preeclampsia occurs, how to predict it better, and to develop experimental clinical trials of new treatments. The Registry will consist of a web-based survey and mechanism for collecting and reviewing medical records. This data will be utilized for immediate investigator-driven cross-sectional research projects (after proposal review by the Registry's scientific advisory board and as directed by the PI). Participants may also choose to be contacted regarding possible participation in future studies, about providing a biospecimen, as well as investigator-driven clinical trials. The Registry is anticipated to exist long-term and to serve as a foundation of participants from which to draw for studies of preeclampsia, anticipated to evolve as our scientific understanding of preeclampsia evolves., conditionsModule conditions: Preeclampsia, conditions: Eclampsia, conditions: HELLP Syndrome, conditions: Toxemia, conditions: Hypertensive Disorder of Pregnancy, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: OTHER, enrollmentInfo count: 20000, type: ESTIMATED, outcomesModule primaryOutcomes measure: Self Reported Diagnosis of Preeclampsia and Hypertensive Disorders of Pregnancy Confirmed by Medical Records, eligibilityModule sex: ALL, minimumAge: 13 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Preeclampsia Foundation, status: RECRUITING, city: Melbourne, state: Florida, zip: 32940, country: United States, contacts name: VeeAnn Argyle, role: CONTACT, phone: 321-421-6957, email: Registry@preeclampsia.org, contacts name: Eleni Z Tsigas, BA, role: PRINCIPAL_INVESTIGATOR, contacts name: Hilary Gammill, MD, role: SUB_INVESTIGATOR, contacts name: James Roberts, MD, role: SUB_INVESTIGATOR, geoPoint lat: 28.08363, lon: -80.60811, hasResults: False
protocolSection identificationModule nctId: NCT06377865, orgStudyIdInfo id: endocrine dis & B thalassemia, briefTitle: Thyroid Function, HbA1c in Relation to Ferritin Level in Adullt Patient e B Thalassemia, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-11-01, completionDateStruct date: 2026-05-01, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: Assiut University, class: OTHER, descriptionModule briefSummary: to evaluate thyroid function ,HbA1C,\&lipid profile in thalassemic patient to correlate thyroid function, Hba1c, lipid profile e ferritin level in thalassemic patient, conditionsModule conditions: B Thalassemia, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 72, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Thyroid function ,Hba1c in relation to ferritin level in adult patients with beta thalassemia, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06377852, orgStudyIdInfo id: Pro00075309, briefTitle: The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-10-28, primaryCompletionDateStruct date: 2028-08-31, completionDateStruct date: 2028-09-01, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: American Society of Clinical Oncology, class: OTHER, collaborators name: Patient-Centered Outcomes Research Institute, descriptionModule briefSummary: The purpose of this study is to generate evidence on an alternative dosing strategy for CDK4/6 inhibitors to help more patients with MBC (age ≥ 65 years) tolerate side effects and stay on treatment longer, to derive the most clinical benefit from these drugs.The primary objective of the CDK Study is to compare TTD on the approved dosing for palbociclib (125 mg orally daily on days 1-21 of 28-day cycle) or ribociclib (600 mg orally daily on days 1-21 of 28-day cycle) vs. TTD using titrated dosing approach with the same schedule but starting at a lower dose of palbociclib (100 mg or 75 mg) or ribociclib (400 mg or 200 mg) and escalating the dose if well-tolerated in combination with provider/patient choice endocrine therapy (AI or fulvestrant) in patients age 65 or older with HR+/HER2- MBC. The secondary and exploratory objectives will generate evidence needed to personalize treatment decisions by comparing patient-centric secondary outcomes and evaluating baseline factors.Together with their treating physician, participants will choose the CDK4/6 inhibitor (palbociclib or ribociclib) and which endocrine therapy (aromatase inhibitor or fulvestrant) of their choice but will be randomized to either Arm 1 (indicated dosing) or Arm 2 (titrated dosing)., conditionsModule conditions: Metastatic Breast Cancer, designModule studyType: INTERVENTIONAL, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: 500 patients will be enrolled, 250 per arm (Arm 1 being indicated dose, Arm 2 being titrated dose)., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 500, type: ESTIMATED, armsInterventionsModule interventions name: Palbociclib, interventions name: Ribociclib, outcomesModule primaryOutcomes measure: Time to Treatment Discontinuation (TTD), secondaryOutcomes measure: Toxicity (grade 3-4 AEs), secondaryOutcomes measure: Event-Free survival (EFS), secondaryOutcomes measure: Quality of life assessed by patient reported outcomes, secondaryOutcomes measure: Time to dose reduction and escalation, secondaryOutcomes measure: Reason for not escalating, secondaryOutcomes measure: Treatment received (missed doses, cumulative dose, etc.), secondaryOutcomes measure: Healthcare utilization (ED visits, hospital admissions, etc.), secondaryOutcomes measure: Body Mass Index, eligibilityModule sex: ALL, minimumAge: 65 Years, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06377839, orgStudyIdInfo id: N-20230048, briefTitle: Pain After Removal of Mandibular Third Molars With or Without Advanced Platelet-rich Fibrin, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-10, primaryCompletionDateStruct date: 2024-04-17, completionDateStruct date: 2025-12-01, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: Aalborg University Hospital, class: OTHER, collaborators name: Aalborg University, descriptionModule briefSummary: Pain is the most common complication following surgical removal of an impacted mandibular third molar. Several risk factors may increase the intensity and duration of pain following removal of mandibular third molars. Acute postoperative pain can transcript into postoperative chronic pain without an explainable reason or a specific risk factor. The use of advanced platelet-rich fibrin in the extraction socket following surgical removal of mandibular third molar have diminished the intensity and duration of acute postoperative pain and facilitated improved wound healing. The objective of the present study is therefore to identified specific risk factors and predictors for developing postoperative chronic pain following surgical removal of mandibular third molars with or without advanced platelet-rich fibrin applied in the extraction socket using epigenetic modulation., conditionsModule conditions: Pain Syndrome, designModule studyType: INTERVENTIONAL, phases: EARLY_PHASE1, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized controlled trial, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Advanced platelet-rich fibrin in the ekstraction socket, outcomesModule primaryOutcomes measure: Assessment of postoperative pain by using Visual Analoque scale, secondaryOutcomes measure: Assessment of quality of life, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Department of Oral and Maxillofacial surgery, Aalborg University Hospital, status: RECRUITING, city: Aalborg, state: Nordjylland, zip: 9000, country: Denmark, contacts name: Thomas Starch-Jensen, Professor, role: CONTACT, phone: +45 23266370, email: thomas.jensen@rn.dk, geoPoint lat: 57.048, lon: 9.9187, hasResults: False
protocolSection identificationModule nctId: NCT06377826, orgStudyIdInfo id: RCRAHS-ISB/REC/MS-PT/01813, briefTitle: Comparison of Aerobic and Resistance Training on Exercise Capacity, Depression and Quality of Life in Hypothyroidism., statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2024-06-01, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: the study will show the effects of aerobic and resistance training on exercise capacity, depression and quality of life in patients with hypothyroidism. The evaluation of TSH level before and after the exercise sessions will provide valuable data., conditionsModule conditions: Comparison of Aerobic Exercise and Resistance Training, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 66, type: ESTIMATED, armsInterventionsModule interventions name: aerobic exercises, interventions name: resistance training, interventions name: medication, outcomesModule primaryOutcomes measure: 6 Minute Walk Test, primaryOutcomes measure: The Beck Depression Inventory Scale, primaryOutcomes measure: SF- 36 SF-36, eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Abbottabad medical complex, status: RECRUITING, city: Abbottābād, state: Khyber Pakhtunkhwa, zip: 21300, country: Pakistan, contacts name: saira jahan, MS, role: CONTACT, phone: 031591289095, email: saira.jahan@riphah.edu.pk, contacts name: Usama Iqbal, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 34.1463, lon: 73.21168, hasResults: False
protocolSection identificationModule nctId: NCT06377813, orgStudyIdInfo id: REC/RCR& AHS/23/01100/Maryam, briefTitle: Combined Mode-Kinetic Chain Exercise With and Without Core Stability Exercises on Patients With Knee Osteoarthritis, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-20, primaryCompletionDateStruct date: 2024-06-01, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: The goal of this \[type of study: Randomized control trial\] is to \[ see the effects of Combined Mode Kinetic Chain Exercises along with or without core stability exercises on pain, range of motion and disability \] in \[ in patients with Knee Osteoarthritis\].The main question it aims to answer is:Wether core stability exercises is effective if performed along with Combined chain kinetic exercises to improves the condition of Knee Osteoarthritis? Group A will receive Core Stability Exercises along with Combined Chain Kinetic Exercises and Group B will receive combined Chain Kinetic Exercises., conditionsModule conditions: Knee Osteoarthritis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Assignment, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 48, type: ESTIMATED, armsInterventionsModule interventions name: Mode-Kinetic Chain Exercise With Core Stability Exercises, interventions name: Mode-Kinetic Chain Exercise, outcomesModule primaryOutcomes measure: Numeric pain rating scale, primaryOutcomes measure: Kellgren and Lawrence system for classification of Osteoarthritis, primaryOutcomes measure: Knee Injury and Osteoarthritic outcome score (KOOS), primaryOutcomes measure: Goniometer, eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Riphah International University, status: RECRUITING, city: Lahore, state: Punjab, zip: 54000, country: Pakistan, contacts name: Muhammad Sanaullah, MS, role: CONTACT, phone: 03224819253, email: muhammad.sanaullah@riphah.edu.pk, contacts name: Maryam Maqsood, DPT, role: CONTACT, phone: 03314815652, email: mail.maryam70@gmail.com, geoPoint lat: 31.558, lon: 74.35071, hasResults: False
protocolSection identificationModule nctId: NCT06377800, orgStudyIdInfo id: REC 01801 Kainat Fatima, briefTitle: Effects Of Navicular Mobilization In Patients With Planter Fasciitis, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2024-06, completionDateStruct date: 2024-07, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: The significance of studying the effects of navicular mobilization in patients suffering from plantar fasciitis lies in its potential to provide valuable insights into non-invasive treatment approaches for a common and debilitating foot condition such as flat foot. Understanding how this therapy impacts navicular height, pain and disability of the foot can lead to improved clinical outcomes and a better understanding of the biomechanical factors contributing to plantar fasciitis. Ultimately, this research may help refine treatment strategies and enhance the quality of life for individuals suffering from this condition, conditionsModule conditions: Plantar Fascitis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 32, type: ESTIMATED, armsInterventionsModule interventions name: navicular mobilization along conventional therapy., interventions name: conventional therapy, outcomesModule primaryOutcomes measure: Numeric Pain Rating Scale, primaryOutcomes measure: (Foot Function Index), primaryOutcomes measure: Navicular drop test, primaryOutcomes measure: Foot print analysis, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 30 Years, stdAges: ADULT, contactsLocationsModule locations facility: DHQ Hospital, city: Faisalābad, state: Punjab, country: Pakistan, contacts name: Maria Khalid, MSOMPT, role: CONTACT, phone: 03315369768, email: maria.khalid@riphah.edu.pk, contacts name: Kainat Fatima, MSOMPT*, role: CONTACT, contacts name: Kainat Fatima, MSOMPT*, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 31.41554, lon: 73.08969, hasResults: False
protocolSection identificationModule nctId: NCT06377787, orgStudyIdInfo id: REC 01732 Aneeqa Zaheer, briefTitle: Effects of ELDOA in Patients With Cervicogenic Headache, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2024-06, completionDateStruct date: 2024-07, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: The aim of our study is to determine the effect of ELDOA in relieving pain, improving ROM and functional disability in patients with cervicogenic headache. This study will add to the growing body of knowledge that if this technique yields comparable outcomes, it would be the alternative therapy. Moreover, it would add to the society as no literature is available on the effect of ELDOA technique in the management of Cervicogenic headache., conditionsModule conditions: Cervicogenic Headache, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 24, type: ESTIMATED, armsInterventionsModule interventions name: ELDOA and conventional therapy, interventions name: conventional therapy, outcomesModule primaryOutcomes measure: (Numeric Pain Rating Scale)., primaryOutcomes measure: NDI (U) (Neck Disability Index), primaryOutcomes measure: Inclinometer, eligibilityModule sex: ALL, minimumAge: 30 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: Alkhidmat Raazi Hospital CBR Town, city: Islamabad, state: Punjab, zip: 46000, country: Pakistan, contacts name: Maria Khalid, MSOMPT, role: CONTACT, phone: 03315369768, email: maria.khalid@riphah.edu.pk, contacts name: Aneeqa Zaheer, MSOMPT*, role: CONTACT, contacts name: Aneeqa Zaheer, MSOMPT*, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.72148, lon: 73.04329, hasResults: False
protocolSection identificationModule nctId: NCT06377774, orgStudyIdInfo id: NFEC-2024-096, briefTitle: To Optimize Therapeutic Procedures of DPMAS in ACLF Patients: a Prospective, Sigle Arm and Multicenter Study, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-03-30, completionDateStruct date: 2026-02-01, studyFirstPostDateStruct date: 2024-04-22, lastUpdatePostDateStruct date: 2024-04-22, sponsorCollaboratorsModule leadSponsor name: Nanfang Hospital, Southern Medical University, class: OTHER, descriptionModule briefSummary: Acute-on-chronic liver failure (ACLF) is a life-threaten syndrome carrying high-short-term mortality raging 40% to 60% within 90 days in patients with chronic liver disease. Double plasma molecular adsorption system (DPMAS) is one of the available artificial liver support systems, which combines plasma filtration and two specific adsorption membranes dedicating to remove bilirubin and the middle molecular toxins respectively. The efficiency of DMPAS treatment in liver failure patients remains controversial. Previous study indicate that liver failure patients with DPMAS therapy improve the short-term mortality and prevent the diseases progression within 28 days (PADSTONE Study). Thus, this single-arm, multicenter and prospective study is to further validate and optimize the therapeutic procedures of DPMAS therapy in ACLF patients., conditionsModule conditions: Acute-On-Chronic Liver Failure, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 2000, type: ESTIMATED, armsInterventionsModule interventions name: No intervention in this study, outcomesModule primaryOutcomes measure: 28-day transplantation-free mortality, primaryOutcomes measure: The disease progression rate, secondaryOutcomes measure: the 90-day transplantation-free mortality, secondaryOutcomes measure: the disease progression, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False