protocolSection identificationModule nctId: NCT06285708, orgStudyIdInfo id: 2023B0193, briefTitle: Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02, primaryCompletionDateStruct date: 2025-07, completionDateStruct date: 2026-01, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: Ohio State University, class: OTHER, descriptionModule briefSummary: The long-term goal of this study is to reduce suicidal thoughts and behaviors among treatment-seeking individuals who also have posttraumatic stress disorder (PTSD). Prolonged exposure (PE) and crisis response plan (CRP) have demonstrated empirical support for reducing suicide attempts as compared to treatment as usual. However, no studies to date have assessed their effectiveness when used in combination. In light of this knowledge gap, the primary objective of this study will be to test the effectiveness of PE augmented with CRP as compared to PE with care as usual (self-guided treatment plan), an active comparator, for the reduction of suicide ideations and attempts for individuals with comorbid PTSD., conditionsModule conditions: PTSD, conditions: Suicidal Ideation, conditions: Suicide, Attempted, conditions: Trauma, Psychological, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Prolonged exposure, outcomesModule primaryOutcomes measure: Beck Scale for Suicidal Ideation (SSI), primaryOutcomes measure: Self-Injurious Thoughts and Behaviors Interview-Revised (SITBI-R), primaryOutcomes measure: PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 (PCL-5), secondaryOutcomes measure: Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 Self-Rated Level 1 Cross-Cutting Symptom Measure, secondaryOutcomes measure: Interpersonal Needs Questionnaire (INQ) - Abbreviated, secondaryOutcomes measure: Beck Hopelessness Scale (BHS) - Abbreviated, secondaryOutcomes measure: Brief Suicide Cognitions Scale (SCS), secondaryOutcomes measure: Difficulties in Emotion Regulation Scale-Short Form (DERS-SF), secondaryOutcomes measure: Monetary Choice Questionnaire (MCQ), secondaryOutcomes measure: Behavioral Inhibition Scale (BIS), secondaryOutcomes measure: Behavioral Activation Scale (BAS), secondaryOutcomes measure: Patient-Reported Outcomes Measurement Information System (PROMIS) Measures, secondaryOutcomes measure: Patient-Reported Outcomes Measurement Information System (PROMIS) Measures, secondaryOutcomes measure: Patient-Reported Outcomes Measurement Information System (PROMIS) Measures, secondaryOutcomes measure: Patient-Reported Outcomes Measurement Information System (PROMIS) Measures, secondaryOutcomes measure: Patient-Reported Outcomes Measurement Information System (PROMIS) Measures, secondaryOutcomes measure: Patient-Reported Outcomes Measurement Information System (PROMIS) Measures, secondaryOutcomes measure: Patient-Reported Outcomes Measurement Information System (PROMIS) Measures, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The Ohio State University, status: RECRUITING, city: Columbus, state: Ohio, zip: 43210, country: United States, contacts name: Jaryd Hiser, role: CONTACT, phone: 614-814-0163, email: jaryd.hiser@osumc.edu, contacts name: Justin Baker, Ph.D., role: SUB_INVESTIGATOR, geoPoint lat: 39.96118, lon: -82.99879, hasResults: False