hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06352372, orgStudyIdInfo id: tPBM Study, briefTitle: Safety and Efficacy of tPBM for Epileptiform Activity in Autism, acronym: tPBM, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2025-04, completionDateStruct date: 2025-06, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: Richard Frye, class: OTHER, descriptionModule briefSummary: For this study, the proposed intervention will be noninvasively delivered near infra-red (NIR) light - transcranial Photobiomodulation (tPBM) - to the brains of autistic children. This will occur, twice a week, for 10 weeks. The NIR light is delivered to specific brain areas by Cognilum, a wearable device developed by Jelikalite. The expected outcome is improved focus, improved eye contact, improved speech, improved behavior, and gains in functional skills. Cognilum may impact the clinical practice of treating autism. At the beginning, at five weeks, and at the end of study, the clinician will complete the CARS-2, SRS, CGI, and a caregiver interview; additionally, questionnaires will be administered to caregivers during one of the 1-hour weekly treatment sessions., conditionsModule conditions: Autism Spectrum Disorder, conditions: EEG With Periodic Abnormalities, conditions: Epilepsy, conditions: Neurodevelopmental Disorders, conditions: Neurological Disorder, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: This is a prospective, open label study comparing 15 individuals with active seizures and 15 individuals with EEG abnormalities before and after treatment with, near infra-red (NIR) light - transcranial Photobiomodulation (tPBM), primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule interventions name: noninvasively delivered near infra-red (NIR) light - transcranial Photobiomodulation (tPBM), outcomesModule primaryOutcomes measure: Childhood Autism Rating Scores (CARS), secondaryOutcomes measure: EEG Delta Power, otherOutcomes measure: Seizure frequency and severity, otherOutcomes measure: Social Responsiveness Scale (SRS), otherOutcomes measure: Clinical Global Impression Scale (CGI), otherOutcomes measure: NIH Toolbox, eligibilityModule sex: ALL, minimumAge: 4 Years, maximumAge: 12 Years, stdAges: CHILD, contactsLocationsModule locations facility: Rossignol Medical Center, city: Phoenix, state: Arizona, zip: 85050, country: United States, contacts name: Richard E Frye, M.D., PhD, role: CONTACT, phone: 321-259-7111, email: drfrye@rossignolmedicalcenter.com, contacts name: Richard E Frye, M.D., PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.44838, lon: -112.07404, hasResults: False
protocolSection identificationModule nctId: NCT06352359, orgStudyIdInfo id: ONC-841-002, briefTitle: Safety, Pharmacokinetics (PK), and Efficacy of ONC 841 in Advanced Solid Tumors, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-30, primaryCompletionDateStruct date: 2025-06-30, completionDateStruct date: 2027-06-30, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-10, sponsorCollaboratorsModule leadSponsor name: OncoC4, Inc., class: INDUSTRY, descriptionModule briefSummary: This is a Phase I open label, dose-escalation study of intravenous (IV) infusion of ONC-841 as a single agent in patients with advanced/metastatic solid tumors. The study will evaluate seven dose levels of ONC-841 starting from 0.03 mg/kg to 30 mg/kg., conditionsModule conditions: Advanced Solid Tumor, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule interventions name: ONC-841, outcomesModule primaryOutcomes measure: Dose Limiting Toxicity (DLT), primaryOutcomes measure: Maximum Toxicity Dose (MTD), secondaryOutcomes measure: Cmax of ONC-841, secondaryOutcomes measure: The serum half-life of ONC-841, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of California at Davis Cancer Center, city: Sacramento, state: California, zip: 95817, country: United States, contacts name: Tianhong Li, MD, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.58157, lon: -121.4944, locations facility: Norton Cancer Center, city: Louisville, state: Kentucky, zip: 40202, country: United States, contacts name: John Hamm, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 38.25424, lon: -85.75941, locations facility: Tranquil Clinical Research, city: Houston, state: Texas, zip: 77598, country: United States, contacts name: John Knecht, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 29.76328, lon: -95.36327, hasResults: False
protocolSection identificationModule nctId: NCT06352333, orgStudyIdInfo id: Parasagittal Vs Cornerpocket, briefTitle: Parasagittal Vs Cornerpocket Approaches, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-02, primaryCompletionDateStruct date: 2024-11-01, completionDateStruct date: 2025-01-01, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: Sohag University, class: OTHER, descriptionModule briefSummary: Brachial plexus blocks are widely used to provide anesthesia for upper limb surgery.Although many different approaches to the brachial plexus block have been described, there is widespread acceptance that injecting at the supraclavicular level is the most reliable method in terms of spread of local anesthetic agent.Each approach of ultrasound guided supraclavicular brachial plexus block (US -SCBPB ) has a different success rate and complications. .A supraclavicular block can provide effective surgical anesthesia of the forearm and hand.The most commonly performed US- SCBPB is the corner pocket approach which was described by Chan et al with probe resting posterior to the clavicle, with postero latero-anteromedial orientation provides a very stable location, but has the disadvantage of "looking" across the first rib, with the apex of the lung visualized close to thePlexus .A new Parasagittal approach for brachial plexus block at the supraclavicular level was studied by Adrian Searle where the arc of the first rib was used to provide a deep limit to needle transit in order to minimize the risk of pneumothorax ;the aim of our study is to further evaluate the parasagittal approach for brachial plexus block and compare it with the popular corner pocket approach, conditionsModule conditions: Supraclavicular Brachial Plexus Block, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Inclusion criteria:* 18to60 yearsold* ASA grade I to II* Elective upper limb surgery, primaryPurpose: SCREENING, maskingInfo masking: NONE, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: supraclavicular ultrasound guided brachial plexus block, outcomesModule primaryOutcomes measure: Needle visibility in both approaches, secondaryOutcomes measure: Duration of sensory and motor block, otherOutcomes measure: Success rate, otherOutcomes measure: Complications, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Sohag university Hospital, city: Sohag, country: Egypt, contacts name: Magdy M Amin, professor, role: CONTACT, geoPoint lat: 26.55695, lon: 31.69478, hasResults: False
protocolSection identificationModule nctId: NCT06352320, orgStudyIdInfo id: XJTU1AF2023LSK-533, briefTitle: Risk Stratification and New Early Prevention and Treatment Strategies for Patients With Cardiomyopathy (STRENGTH）, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-12-31, primaryCompletionDateStruct date: 2030-08-31, completionDateStruct date: 2032-08-31, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: First Affiliated Hospital Xi'an Jiaotong University, class: OTHER, descriptionModule briefSummary: This study will include patients with different types of cardiomyopathy from multiple centers were prospectively enrolled in a retrospective study to establish a natural population cohort of cardiomyopathy patients. By collecting clinical data and biological samples from surgical patients, we will construct a prognostic system for cardiomyopathy, optimize risk stratification, explore new strategies for the early prevention and treatment of cardiomyopathy, and improve the efficiency of clinical cardiomyopathy patients' diagnosis and treatment., conditionsModule conditions: Cardiomyopathies, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: OTHER, enrollmentInfo count: 500, type: ESTIMATED, armsInterventionsModule interventions name: Diagnosis of HCM, interventions name: Diagnosis of DCM, interventions name: Diagnosis of ARVC, interventions name: Diagnosis of NDLVC, interventions name: Diagnosis of RCM, interventions name: Diagnosis of LVNC, outcomesModule primaryOutcomes measure: Change in the incidence of mortality rate, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: First Affiliated Hospital of Xi'an Jiantong University, city: Xi'an, state: Shaanxi, zip: 710061, country: China, geoPoint lat: 34.25833, lon: 108.92861, hasResults: False
protocolSection identificationModule nctId: NCT06352307, orgStudyIdInfo id: XJTU1AF2023LSK-532, briefTitle: Risk Stratification, Early Prevention and Treatment Strategies for Arrhythmogenic Cardiomyopathy, acronym: STARTER, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-12-31, primaryCompletionDateStruct date: 2030-08-31, completionDateStruct date: 2032-08-31, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: First Affiliated Hospital Xi'an Jiaotong University, class: OTHER, descriptionModule briefSummary: This study will include patients diagnosed with Arrhythmogenic cardiomyopathy (ACM) in the First Affiliated Hospital of Xi 'an Jiaotong University and other centers, and collect clinical data and biological samples of patients with different ACM phenotypes. Through the establishment of disease cohort and long-term follow-up, to explore the disease characteristics, development law, clinical characteristics, natural course of disease and long-term prognosis of ACM., conditionsModule conditions: Arrhythmogenic Cardiomyopathy, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: OTHER, enrollmentInfo count: 1500, type: ESTIMATED, armsInterventionsModule interventions name: Diagnosis of ACM, outcomesModule primaryOutcomes measure: Change in the incidence of mortality rate, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: First Affiliated Hospital of Xi'an Jiantong University, city: Xi'an, state: Shaanxi, zip: 710061, country: China, contacts name: Guoliang Li, role: CONTACT, phone: 008613759982523, email: liguoliang_med@163.com, contacts name: Yang Yan, role: CONTACT, phone: +86.29.85323869, email: yangyan3@xjtu.edu.cn, geoPoint lat: 34.25833, lon: 108.92861, hasResults: False
protocolSection identificationModule nctId: NCT06352294, orgStudyIdInfo id: MSDALAKCI, briefTitle: The Effects of Myofascial Relaxation Technique Applied Together With Core Stabilization Trainings on Balance, Pain, Joint Range of Motion and Functionality in Individuals With Chronic Neck Pain, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-29, primaryCompletionDateStruct date: 2024-07, completionDateStruct date: 2024-07, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: Kirsehir Ahi Evran Universitesi, class: OTHER, descriptionModule briefSummary: Chronic neck pain is a musculoskeletal disorder that affects people frequently in life. Nov.Postural control is based on the process of correctly identifying and selectively focusing the incoming afferent input of the Central Nervous System (CNS).The main treatment options for people with neck pain include soft tissue and joint mobilizations, stabilization exercises for the neck, trunk and shoulder muscles, cervical Deckings, relaxation training, strengthening exercises and body awareness and posture training Nov.In this study, it was aimed to investigate the effects of myofascial relaxation on balance, pain, joint range of motion and functionality in individuals with chronic neck pain by dividing them into two groups in the form of core stabilization and core stabilization and myofascial relaxation.The study included 45 people between the ages of 18 and 65 Dec. In two groups, the core stabilization group will be 22 people, and the core stabilization and myofascial relaxation group will be 23 people. The study period is planned as 6 weeks and 3 sessions per week., conditionsModule conditions: Neck Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 45, type: ESTIMATED, armsInterventionsModule interventions name: Core stability training, interventions name: Core stability training and myofascial relase, outcomesModule primaryOutcomes measure: Pain severity, primaryOutcomes measure: Pressure pain threshold (PPT), secondaryOutcomes measure: Balance, secondaryOutcomes measure: Range of motion, secondaryOutcomes measure: Neck Disability İndex, secondaryOutcomes measure: DASH, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Kırşehir Ahi Evran Üniversitesi, status: RECRUITING, city: Merkez, state: Kırşehir, country: Turkey, contacts name: Muhammed Samed Dalakçı, role: CONTACT, phone: 905445325572, email: samed.dalakci@gmail.com, hasResults: False
protocolSection identificationModule nctId: NCT06352281, orgStudyIdInfo id: KM-007, briefTitle: Efficacy and Safety of CAR-T Cells Therepy for Chronic or Refractory Primary Immune Thrombocytopenia (ITP), statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-01, primaryCompletionDateStruct date: 2026-01-01, completionDateStruct date: 2027-12-31, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China, class: OTHER, descriptionModule briefSummary: It is a single-center, single-arm, open-labeled clinical trial to evaluate the efficacy and safety of CAR-T cells therapy for Chronic or Refractory Primary Immune Thrombocytopenia (ITP)., conditionsModule conditions: ITP - Immune Thrombocytopenia, designModule studyType: INTERVENTIONAL, phases: PHASE1, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: CAR-T cells, outcomesModule primaryOutcomes measure: Portion of patients with response (R), secondaryOutcomes measure: Portion of patients with complete response (CR), secondaryOutcomes measure: Portion of patients with relapse, secondaryOutcomes measure: Time (in days) from treatment start to response (R), secondaryOutcomes measure: Time (in days) from treatment to complete response (CR), secondaryOutcomes measure: Duration (in days) of response (R), secondaryOutcomes measure: Incidence of adverse events(AE) after infusion, eligibilityModule sex: ALL, minimumAge: 8 Years, maximumAge: 75 Years, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China, status: RECRUITING, city: Kunming, state: Yunnan, zip: 650000, country: China, contacts name: Wang Sanbin, Doctor, role: CONTACT, phone: 13187424131, phoneExt: +86, email: sanbin1011@163.com, geoPoint lat: 25.03889, lon: 102.71833, hasResults: False
protocolSection identificationModule nctId: NCT06352268, orgStudyIdInfo id: IEC-368/17.07.2023, briefTitle: Lesioning Procedures for Movement Disorders, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-15, primaryCompletionDateStruct date: 2027-12-31, completionDateStruct date: 2028-12-31, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: All India Institute of Medical Sciences, New Delhi, class: OTHER, descriptionModule briefSummary: Dystonia is a rare syndrome with varying etiologies. Similarly, tremor conditions refractory to medical management and disabling that they need surgical interventions are rare in our setting. So far there are no randomized controlled trials of pallidotomy for management of dystonia. There is scant literature on the long term efficacy and safety of Pallidotomy, thalamotomy and other such lesioning procedures in the management of movement disorders. The current literature is significantly plagued by publication bias as case reports with successful outcomes are likely to be selectively published in journals or conference abstracts. Lesioning procedures though seem to be effective are often considered to be risky, especially bilateral pallidotomy is not preferred by several centres. However, our center routinely performs simultaneous bilateral pallidotomy. To generate long term data on the efficacy and safety of lesioning procedures in rare diseases like dystonias especially the effect of functional neurosurgery on varying etiologies of the disease, robust registries are required which collect data on all consecutive patients who undergo the procedure., conditionsModule conditions: Dystonia, conditions: Parkinson Disease, conditions: Essential Tremor, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 250, type: ESTIMATED, armsInterventionsModule interventions name: Pallidal, subthalamic or thalamic lesioning, outcomesModule primaryOutcomes measure: Long term functional outcomes, primaryOutcomes measure: Long term functional outcomes, secondaryOutcomes measure: Predictors of outcomes, secondaryOutcomes measure: Demography, secondaryOutcomes measure: Clinical features, secondaryOutcomes measure: Laboratory findings, secondaryOutcomes measure: Imaging features, secondaryOutcomes measure: Treatment trends, secondaryOutcomes measure: Clinical features, secondaryOutcomes measure: Treatment trends, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: All India Institute of Medical Sciences, New Delhi, city: New Delhi, state: Delhi, zip: 110029, country: India, contacts name: Arunmozhimaran Elavarasi, MD DM, role: CONTACT, phone: +919013844274, email: arun_ela@yahoo.com, geoPoint lat: 28.63576, lon: 77.22445, hasResults: False
protocolSection identificationModule nctId: NCT06352255, orgStudyIdInfo id: AR1937, briefTitle: Pain and Anxiety During Local Block, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-07, primaryCompletionDateStruct date: 2024-12, completionDateStruct date: 2025-07, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: University of Seville, class: OTHER, descriptionModule briefSummary: INTRODUCTION: Currently, there is no scientific evidence about pain in the anesthetic blockage of the first finger according to the application method. However, clinical evidence has valued the use of carpule, due to the low pain it generates in the patient to the application of anesthetic. Most studies on anesthesia and pain, especially with the use of carpule and distracting methods, belong to the field of dentistry.OBJECTIVES: It is intended to determine the pain after an anesthetic block in H of Frost in the first finger with different application methods, such as syringe and carpule. As secondary objectives, it is intended to establish the difference in pain according to the sex and age of the patients.METHODOLOGY: Experimental, transverse and random clinical trial type analytical study, in which a sample of 200 individuals will be selected, 100 per group, which would require digital anesthesia of the first finger and that would fulfill the inclusion criteria.Result: after the completion of the study CONCLUSIONS: After the completion of the study, conditionsModule conditions: Anesthesia, Local, conditions: Pain, conditions: Anxiety, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: OTHER, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 200, type: ESTIMATED, armsInterventionsModule interventions name: Digital block, outcomesModule primaryOutcomes measure: Grade of Pain postinyection, secondaryOutcomes measure: Anxiety before the intervention, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False