protocolSection identificationModule nctId: NCT06371131, orgStudyIdInfo id: PONV of Thyroid Surgery, briefTitle: Effect of Stellate Ganglion Block on Postoperative Nausea and Vomiting, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-04-17, primaryCompletionDateStruct date: 2024-05-30, completionDateStruct date: 2024-08-30, studyFirstPostDateStruct date: 2024-04-17, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: The Second Affiliated Hospital of Chongqing Medical University, class: OTHER, descriptionModule briefSummary: Postoperative nausea and vomiting is one of the most common postoperative complications second only to postoperative pain. Studies have reported that without any antiemetic prevention treatment, the overall incidence of PONV in surgical operations is up to 20-30%, and the incidence of PONV in high-risk patients such as thyroid surgery is even up to 70-80%. PONV not only increased discomfort and prolonged hospital stay; Severe cases can lead to wound dehysis, acid-base imbalance, water and electrolyte metabolism disorders, seriously affect the prognosis of patients. Although various prevention and treatment measures have been adopted in clinical practice, it still cannot be completely eliminated. Therefore, postoperative nausea and vomiting of thyroid is still a concern in clinical anesthesia work, so it is urgent to explore more simple and effective measures to prevent thyroid PONV. SGB is the injection of local anesthetics into loose connective tissue containing stellate ganglion. It has a clear effect on postoperative analgesia of thyroid surgery, and can play a certain role in preventing thyroid PONV by reducing the application of perioperative opioids. Few studies have reported that the incidence of PONV can be significantly reduced after the application of SGB in patients with thyroid surgery, which provides a certain basis for the prevention of thyroid PONV. Therefore, this study aims to explore the effect of right stellate ganglion block on preventing postoperative nausea and vomiting of thyroid, and to explore the possible mechanism of action., conditionsModule conditions: Stellate Ganglion Block, conditions: Thyroid Surgery, conditions: Postoperative Nausea and Vomiting, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Experimental group: right stellate ganglion block 30 minutes before anesthesia induction.Control group: No treatment was given 30minutes before anesthesia induction.Data was recorded at the corresponding time points., primaryPurpose: HEALTH_SERVICES_RESEARCH, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 200, type: ESTIMATED, armsInterventionsModule interventions name: Right -stellate ganglion block, outcomesModule primaryOutcomes measure: Incidence of Postoperative nausea and vomiting, secondaryOutcomes measure: Incidence of Postoperative nausea and vomiting during preemptive analgesia, secondaryOutcomes measure: Intensity of nausea and vomiting during preemptive analgesia, secondaryOutcomes measure: Intensity of nausea and vomiting during hospitalization, secondaryOutcomes measure: Hemodynamic parameters after preemptive analgesia, secondaryOutcomes measure: Postoperative pain intensity, secondaryOutcomes measure: Recovery of gastrointestinal function, secondaryOutcomes measure: Sleep quality, secondaryOutcomes measure: Satisfaction score and postoperative analgesia satisfaction score, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The Second Affiliated Hospital of Chongqing Medical University, status: RECRUITING, city: Chongqing, state: Chongqing, zip: 400000, country: China, contacts name: ling Dan, BD, role: CONTACT, phone: 86 13983072922, email: 302069@hospital.cqmu.edu.cn, geoPoint lat: 29.56278, lon: 106.55278, hasResults: False