protocolSection identificationModule nctId: NCT06271122, orgStudyIdInfo id: COMPET-1, briefTitle: Identification of Explanatory Factors for the Lack of Muscle Strength Gain Following a Pulmonary Rehabilitation Program in COPD Patients, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-18, primaryCompletionDateStruct date: 2025-05-16, completionDateStruct date: 2025-05-16, studyFirstPostDateStruct date: 2024-02-21, lastUpdatePostDateStruct date: 2024-02-21, sponsorCollaboratorsModule leadSponsor name: Korian, class: OTHER, descriptionModule briefSummary: Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease associated with various comorbidities, including muscle weakness (MW), which is very worrying due to its negative impact on patients' quality of life and survival. To address this issue, muscle strengthening is incorporated into pulmonary rehabilitation programs. However, its effectiveness is unclear, as although there is an average improvement in muscle strength, one in two patients does not show a clinically relevant improvement. To understand this non-response, it is crucial to examine the effect of muscle strengthening programs on the two main determinants of force production: the muscle and the central command. Muscle adaptations following a muscle strengthening program are well-documented, showing improvements in muscle function (cross-sectional area, lean mass, etc.). Conversely, only one study has investigated central adaptations after a muscle strengthening program, clearly demonstrating a lack of effect.The investigators hypothesize that patients showing no improvement in muscle strength after pulmonary rehabilitation (non-responders) have a significantly lower level of voluntary activation before starting the program compared to responding patients (responders)., conditionsModule conditions: Chronic Obstructive Pulmonary Disease, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 36, type: ESTIMATED, armsInterventionsModule interventions name: Voluntary activation assessed by magnetic stimulation, outcomesModule primaryOutcomes measure: Central voluntary activation assessed by transcranial magnetic stimulation (TMS), secondaryOutcomes measure: Muscle excitability assessed by femoral magnetic stimulation (FMS), secondaryOutcomes measure: Contractile properties assessed by femoral magnetic stimulation (FMS), secondaryOutcomes measure: Corticospinal excitability assessed by transcranial magnetic stimulation (TMS), secondaryOutcomes measure: Intra-cortical inhibitions transcranial magnetic stimulation (TMS), secondaryOutcomes measure: Voluntary activation assessed by femoral magnetic stimulation (FMS), eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Clinique du Souffle La Vallonie, status: RECRUITING, city: Lodève, zip: 34700, country: France, contacts name: Nelly Heraud, PhD, role: CONTACT, phone: +33467888491, email: nelly.heraud@clariane.fr, contacts name: Nicolas Oliver, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 43.71667, lon: 3.31667, hasResults: False