protocolSection identificationModule nctId: NCT06323278, orgStudyIdInfo id: PD&REHAB, briefTitle: Effectiveness of Cognitive Stimulation Treatment in Patients With Parkinson's Disease, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-12-21, primaryCompletionDateStruct date: 2026-12, completionDateStruct date: 2027-12, studyFirstPostDateStruct date: 2024-03-21, lastUpdatePostDateStruct date: 2024-03-21, sponsorCollaboratorsModule leadSponsor name: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, class: OTHER, descriptionModule briefSummary: The goal of this observational study is to evaluate the relationship between GBA mutation and cognitive stimulation treatment response in patients with Parkinson's disease. The main questions it aim to answer are: • assess whether the GBA mutation is associated with greater or lesser response to cognitive training treatment compared to a control group of PD patients without genetic mutations. • investigate the effect of cognitive stimulation program on behavioural aspects as secondary consequence induced by the possible improvement of cognitive abilities following treatment.Participants will be undergo to: - a neuropsychological evaluation describing their cognitive profile; - a genetic investigation and finally included in a cognitive stimulation programs according to regular clinical practice. Researchers will compare PD patients with GBA mutation and patients without genetic mutation to evaluate the effectiveness of cognitive stimulation treatment., conditionsModule conditions: Parkinson Disease, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 68, type: ESTIMATED, armsInterventionsModule interventions name: Cognitive training, outcomesModule primaryOutcomes measure: Efficacy of the cognitive training on cognitive function in PD patients with GBA mutation compared to a control group of PD patients without genetic mutations., secondaryOutcomes measure: The effect of cognitive training on behavioural aspects in PD patients., secondaryOutcomes measure: The effect of cognitive training on behavioural aspects in PD patients., secondaryOutcomes measure: The effect of cognitive training on behavioural aspects in PD patients., secondaryOutcomes measure: The effect of cognitive training on behavioural aspects in PD patients., secondaryOutcomes measure: The effect of cognitive training on behavioural aspects in PD patients., secondaryOutcomes measure: The effect of cognitive training on behavioural aspects in PD patients., secondaryOutcomes measure: The effect of cognitive training on behavioural aspects in PD patients., secondaryOutcomes measure: The effect of cognitive training on behavioural aspects in PD patients., eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, status: RECRUITING, city: Milan, country: Italy, contacts name: Fabiana Ruggiero, MSc in Psychology, role: CONTACT, phone: +390255033621, email: fabiana.ruggiero@policlinico.mi.it, geoPoint lat: 45.46427, lon: 9.18951, hasResults: False