hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06351306, orgStudyIdInfo id: AAAU5915, briefTitle: DEC-C and Thioguanine for R/R AML, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-30, primaryCompletionDateStruct date: 2027-12, completionDateStruct date: 2027-12, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: Joseph Jurcic, class: OTHER, descriptionModule briefSummary: The purpose of this study is to find out if oral decitabine-cedazuridine (Inqovi®) is effective, safe, and able to be tolerated without severe side effects when given with thioguanine (Tabloid®) in patients with acute myeloid leukemia (AML) whose disease has returned or did not respond to treatment (relapsed or refractory).This is a "phase II trial with a safety lead-in." The goal of the lead-in portion of the study is to make sure participants are getting the highest dose of medications that are safe. If too many serious side effects are seen with the dose previously studied, some additional patients may be treated with a lower dose to make sure that this dose is safe., conditionsModule conditions: Acute Myeloid Leukemia, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 48, type: ESTIMATED, armsInterventionsModule interventions name: Thioguanine (Tabloid ®), interventions name: DecitabineCedazuridine (Inqovi ®), outcomesModule primaryOutcomes measure: Composite Complete Remission (CRc) Rate, secondaryOutcomes measure: Duration of Remission, secondaryOutcomes measure: Time to Complete Remission (CR), secondaryOutcomes measure: Overall Survival (OS), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Columbia University, status: RECRUITING, city: New York, state: New York, zip: 10032, country: United States, contacts name: Research Nurse Navigator, role: CONTACT, phone: 212-342-5162, email: cancerclinicaltrials@cumc.columbia.edu, contacts name: Joseph G. Jurcic, MD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 40.71427, lon: -74.00597, hasResults: False
protocolSection identificationModule nctId: NCT06351293, orgStudyIdInfo id: GLI.04.US.SL.034, briefTitle: A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2024-02-21, primaryCompletionDateStruct date: 2025-02-28, completionDateStruct date: 2025-02-28, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-11, sponsorCollaboratorsModule leadSponsor name: Galderma R&D, class: INDUSTRY, descriptionModule briefSummary: This is a randomized, split-face, subject-blinded, comparative study. Subjects will receive initial treatment with Defyne on one of the NLFs and with RHA3 on the other based on the pre-determined randomization.4 weeks after the initial treatment, subjects will receive optional touch-up on one side or both sides at the Investigator's discretion for optimal correction.Subjects to return to the site at Month 3, 6, and 12 for follow-ups., conditionsModule conditions: Wrinkle, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: Subjects will be blinded to the treatment assignment, in which randomization and treatment side will be concealed in order to avoid bias in subjective assessment. The clinic staff will mask the product identity by covering the packaging and product name (e.g., using tape, marker, wipe-out, etc.) so that it is not visible to the subjects. The Investigator will not be blinded., whoMasked: PARTICIPANT, enrollmentInfo count: 15, type: ESTIMATED, armsInterventionsModule interventions name: Defyne Treatment in Nasolabial Fold, interventions name: RHA3 Treatment in Nasolabial Fold, outcomesModule primaryOutcomes measure: Visual Comparison of Nasolabial Fold Ultrasounds, secondaryOutcomes measure: Volume Change Imaging Analysis, eligibilityModule sex: ALL, minimumAge: 22 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The Aesthetic Clinique, city: Santa Rosa Beach, state: Florida, zip: 32459, country: United States, geoPoint lat: 30.39603, lon: -86.22883, hasResults: False
protocolSection identificationModule nctId: NCT06351280, orgStudyIdInfo id: Sana Nasir Zaidi, briefTitle: Evaluation of Performance-based Functional Outcome Measures After Open Abdominal Surgery, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04, primaryCompletionDateStruct date: 2024-06, completionDateStruct date: 2024-07, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: A laparotomy is a surgical technique, the increasing rate of this surgical interventions and the subsequent need to evaluate the post-surgical recovery and rehabilitation process comprehensively. This study aims to provide essential insights into the reliability, validity, and responsiveness of such tests, enabling healthcare professionals to make informed decisions about patient recovery progress and the optimization of rehabilitation protocols., conditionsModule conditions: Laparotomy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Standardised Physiotherapy Plan, outcomesModule primaryOutcomes measure: 6MWT (Six-Minute Walk Test), primaryOutcomes measure: 5 Times Sit to Stand, primaryOutcomes measure: 2MWT (Two-Minute Walk Test), primaryOutcomes measure: Timed Up and GO (TUG), eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Fauji Foundation Hospital, city: Rawalpindi, state: Punjab, zip: 00666, country: Pakistan, contacts name: Suman Sheraz, PhD*, role: CONTACT, phone: 03335646361, email: suman.sheraz@riphah.edu.pk, contacts name: Sana Nasir, MS-CPPT*, role: SUB_INVESTIGATOR, contacts name: Suman Sheraz, PhD*, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.6007, lon: 73.0679, hasResults: False
protocolSection identificationModule nctId: NCT06351267, orgStudyIdInfo id: REC/RCR & AHS/23/0568, briefTitle: Combined Effects of Core Stability Exercises and Back Strengthening Exercises on Pregnancy-Induced Back Pain., statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-05, primaryCompletionDateStruct date: 2024-10-01, completionDateStruct date: 2024-10-15, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: The study will be a Randomized controlled trial to check the combined effects of Core Stability Exercises with and without Back strengthening exercises in females with pregnancy-induced back pain, disability, and function so that we can examine the effect of the above techniques on pain, disability and function in pregnant females Non-probability convenience sampling technique will be used, subject following eligibility criteria from Society Hospital Nabipura Lahore will be randomly allocated in two groups. Group A participants will be given core stability exercises with back strengthening exercises, Group B participants will be given core stability exercises for 4 weeks. Assessment will be done via, Numeric Pain Rating Scale, Oswestry disability index questionnaire and Back pain Functional Scale., conditionsModule conditions: Low Back Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 34, type: ESTIMATED, armsInterventionsModule interventions name: Core Stability Exercises, interventions name: Back Strengthening exercises, outcomesModule primaryOutcomes measure: Numeric Pain Rating Scale, primaryOutcomes measure: Oswestry Disability Index Questionnaire, primaryOutcomes measure: Back Pain Functional Scale (BPFS):, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: Society Hospital Nabipura, city: Lahore, state: Punjab, zip: 54700, country: Pakistan, contacts name: Ghulam Fatima, PhD*, role: CONTACT, phone: +923034073057, email: ghulam.fatima@riphah.edu.pk, geoPoint lat: 31.558, lon: 74.35071, hasResults: False
protocolSection identificationModule nctId: NCT06351254, orgStudyIdInfo id: REC/RCR & AHS/23/01101nayab, briefTitle: Kinesthetic Exercises and Sine Sound Waves in Cervical Spondylosis, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-20, primaryCompletionDateStruct date: 2024-06-01, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: Riphah International University, class: OTHER, descriptionModule briefSummary: The goal of this Randomized control trial is to determine the Effect of kinesthetic exercises and sound waves on pain, ROM, shoulder alignment and disability in cervical spondylosis. The main question it aims to answer is:Weather sine sound and kinesthetic exercise are effective in management of pain, rom, alignment, and disability in patients that are suffering from cervical spondylosis, conditionsModule conditions: Cervical Spondylosis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 24, type: ESTIMATED, armsInterventionsModule interventions name: Sine sound waves, interventions name: Kinesthetic exercises, interventions name: Sine sound waves plus kinesthetic exercises, outcomesModule primaryOutcomes measure: NPRS, primaryOutcomes measure: Inclinometer, primaryOutcomes measure: Goniometer, primaryOutcomes measure: NDI, eligibilityModule sex: ALL, minimumAge: 45 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Riphah international university, status: RECRUITING, city: Lahore, state: Punjab, zip: 54000, country: Pakistan, contacts name: Muhammad Sanaullah, role: CONTACT, phone: 03224819253, email: muhammad.sanaullah@riphah.edu.pk, geoPoint lat: 31.558, lon: 74.35071, hasResults: False
protocolSection identificationModule nctId: NCT06351241, orgStudyIdInfo id: E.222840/280, briefTitle: Hemodynamic Effects of Steep Trendelenburg Position and Pneumoperitoneum, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-11-29, primaryCompletionDateStruct date: 2023-04-14, completionDateStruct date: 2023-04-14, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: Ege University, class: OTHER, descriptionModule briefSummary: BACKGROUND: The steep Trendelenburg position and pneumoperitoneum are used to improve surgical visibility in robot-assisted laparoscopic radical prostatectomy (RALRP). However, these procedures can lead to hemodynamic changes. This study aimed to investigate the effects of these interventions on the perfusion index (PI) and the Pleth variability index (PVI) in patients undergoing RALRP under general anesthesia.METHODS: Fifty-three patients scheduled for RALRP underwent standard monitoring; PI and PVI values were monitored using a finger probe. PI, PVI, hemodynamic and respiratory parameters, and intraabdominal pressure were recorded before and after anesthesia induction, after adopting the Trendelenburg position, after pneumoperitoneum, after pneumoperitoneum and the Trendelenburg position, at 15 min, 30 min, in the supine position, after carbon dioxide (CO2) desufflation, and after extubation., conditionsModule conditions: Perfusion Index, conditions: Pleth Variability Index, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 53, type: ACTUAL, outcomesModule primaryOutcomes measure: Hemodynamic effects of steep trendelenburg position and pneumoperitoneum in urologic robotic surgery, eligibilityModule sex: MALE, minimumAge: 25 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Nursen Karaca, city: Bornova, state: İzmir, zip: 35040, country: Turkey, geoPoint lat: 38.47921, lon: 27.2399, hasResults: False
protocolSection identificationModule nctId: NCT06351228, orgStudyIdInfo id: 5720, briefTitle: Fertility-sparing in Early-stage Cervcial Cancer: The ETERNITY Project, acronym: Eternity, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-30, primaryCompletionDateStruct date: 2024-12-31, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, class: OTHER, descriptionModule briefSummary: The ETERNITY project is a retrospective analysis of outcomes of patients undergoing fertility-sparing treatment for cervcial cancer.The primary aim is to report outcomes of those patients.Other aims included:1. Evaluation about the effectiveness of different treatment modalities;2. Evaluation of outcomes according to different stages of disease;3. Evaluation of the impactof neoadjuvant chemotherapy in patients undergoing conservative surgery, conditionsModule conditions: Cervical Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 400, type: ESTIMATED, armsInterventionsModule interventions name: Conization plus nodal evaluation, outcomesModule primaryOutcomes measure: oncological outcomes, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, city: Milano, state: Lombardia, zip: 20133, country: Italy, geoPoint lat: 45.46427, lon: 9.18951, hasResults: False
protocolSection identificationModule nctId: NCT06351215, orgStudyIdInfo id: APP-24-00554, briefTitle: PO Methadone Ortho Outpatient, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-01, primaryCompletionDateStruct date: 2024-12-01, completionDateStruct date: 2024-12-15, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: Keck School of Medicine of USC, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to learn if oral methadone given before surgery works to minimize post-operative pain and opioid usage. The main questions it aims to answer are:Does oral methadone improve post-operative pain scores as compared to standard treatment? Does oral methadone lead to reduced use of post-operative and post-discharge opioid usage as compared to the current standard treatment?Researchers will compare oral methadone to a placebo (a look-alike substance that contains no drug) to assess the questions above.Participants will:Receive either oral methadone or a look-alike placebo before surgery Receive standard intraoperative and immediate post-operative pain control at the anesthesiologist's discretion Be asked about their pain levels in the recovery area Keep a diary of pain and opioid usage over the first 2 days after surgery, conditionsModule conditions: Arthroscopic Knee Repair, conditions: Arthroscopic Hip Repair, designModule studyType: INTERVENTIONAL, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Methadone group, interventions name: Placebo, outcomesModule primaryOutcomes measure: Post-op opioid usage, secondaryOutcomes measure: Post-op Pain Score, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: USC Healthcare Consultation 3, city: Los Angeles, state: California, zip: 90033, country: United States, contacts name: Alexander Chen, M.D., role: CONTACT, phone: 323-442-7400, email: painmed@usc.edu, contacts name: Abigail Song, B.S., role: SUB_INVESTIGATOR, contacts name: Benjamin Liu, M.D., role: SUB_INVESTIGATOR, contacts name: Paul Lee, M.D., M.S., role: SUB_INVESTIGATOR, geoPoint lat: 34.05223, lon: -118.24368, hasResults: False
protocolSection identificationModule nctId: NCT06351163, orgStudyIdInfo id: 1451_03/BVNTW-VNCSKTE, briefTitle: Minimally Invasive Surgical Management for Pediatric Intussusception: A Retrospective Cohort Study, statusModule overallStatus: COMPLETED, startDateStruct date: 2016-01, primaryCompletionDateStruct date: 2020-12, completionDateStruct date: 2024-03, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: National Children's Hospital, Vietnam, class: OTHER, collaborators name: Vinmec Research Institute of Stem Cell and Gene Technology, descriptionModule briefSummary: Intussusception is the primary cause of intestinal obstruction in children aged 3 months to 5 years, leading to significant morbidity and mortality rates. Most cases involve the ileocolic region and can often be resolved through air enema, with a success rate of up to 95%. Surgical intervention becomes necessary if pneumatic reduction fails or is not recommended. Traditionally, manual reduction required a large incision on the right side of the abdomen. However, the advancement of minimally invasive techniques, such as the laparoscopic approach (LAP), has become increasingly popular for managing intussusception. LAP offers benefits such as reduced surgical trauma and shorter operative times compared to open procedures. Nevertheless, the adoption of LAP remains controversial due to challenges like limited working space in children and variability in the affected bowel segment. This study aims to investigate the safety and feasibility of LAP and mini-open reduction (MOR) techniques in treating idiopathic intussusception in pediatric patients., conditionsModule conditions: Intussusception, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: RETROSPECTIVE, enrollmentInfo count: 181, type: ACTUAL, armsInterventionsModule interventions name: Laparoscopic reduction, interventions name: Transumbilical mini-open reduction, outcomesModule primaryOutcomes measure: Operating time, primaryOutcomes measure: Intraoperative complications, primaryOutcomes measure: Immediate postoperative complications, primaryOutcomes measure: Time to feed, primaryOutcomes measure: Hospital stays, primaryOutcomes measure: Recurrence rate, primaryOutcomes measure: Long-term complication rate, eligibilityModule sex: ALL, minimumAge: 2 Months, maximumAge: 12 Years, stdAges: CHILD, contactsLocationsModule locations facility: The National Hospital of Pediatrics, city: Hanoi, country: Vietnam, geoPoint lat: 21.0245, lon: 105.84117, locations facility: Vinmec Research Institute of Stem Cell and Gene Technology, city: Hanoi, country: Vietnam, geoPoint lat: 21.0245, lon: 105.84117, hasResults: False
protocolSection identificationModule nctId: NCT06351137, orgStudyIdInfo id: INIV2023, briefTitle: Timecost of Intranasal Versus Intravenous Analgesia in Traumatic Pain, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-13, primaryCompletionDateStruct date: 2024-06-01, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), class: OTHER, descriptionModule briefSummary: Prehospital treatment of acute traumatic pain is common in military practice. Analgesics are usually administered intravenously (IV). Research from the civil prehospital environment shows that obtaining IV access can be difficult and time consuming, delaying onset of treatment. The challenges for obtaining IV access in the military prehospital setting are even bigger, for example in combat environments. However, this has not been assessed.Current guidelines also offer alternative routes of administration for analgesics, for example intranasal (IN) administration. IN administration is a fast, easy and effective route of administration. This study determines whether IN administration of analgesia is faster and leads to increased healthcare provider satisfaction compared to IV administration in patients with acute traumatic pain in a simulated military prehospital environment., conditionsModule conditions: Acute Pain Due to Trauma, conditions: Analgesia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 16, type: ESTIMATED, armsInterventionsModule interventions name: Intravenous administration, interventions name: Intranasal administration, outcomesModule primaryOutcomes measure: Time required for administration of analgesic (minutes), secondaryOutcomes measure: Total time spent on scene (minutes), secondaryOutcomes measure: Time required for obtaining IV access, secondaryOutcomes measure: Time required preparing IN administration, secondaryOutcomes measure: Satisfaction of the navy nurse regarding the used route of administration., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Amsterdam UMC, status: RECRUITING, city: Amsterdam, state: Noord-Holland, zip: 1105AZ, country: Netherlands, contacts name: Midas N de Grunt, MD, role: CONTACT, phone: +31205669111, email: m.n.degrunt@amsterdamumc.nl, contacts name: Markus W Hollmann, PhD, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 52.37403, lon: 4.88969, hasResults: False
protocolSection identificationModule nctId: NCT06351111, orgStudyIdInfo id: IRB-24-240, briefTitle: [Trial of device that is not approved or cleared by the U.S. FDA], statusModule overallStatus: WITHHELD, studyFirstPostDateStruct date: 2024-04-08, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: [Redacted], hasResults: False