protocolSection identificationModule nctId: NCT06298006, orgStudyIdInfo id: 275025, briefTitle: A Two Year Longitudinal Clinical Study of Neurocognitive and Psychiatric Symptoms in Post COVID-19 Patients, acronym: PASC24, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-02-22, primaryCompletionDateStruct date: 2026-12-31, completionDateStruct date: 2027-06-30, studyFirstPostDateStruct date: 2024-03-07, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: Region Örebro County, class: OTHER, collaborators name: Örebro University, Sweden, collaborators name: Karolinska Institutet, collaborators name: Karolinska University Hospital, collaborators name: Sahlgrenska University Hospital, Sweden, descriptionModule briefSummary: The prospective, longitudinal, open observational study monitors patients with cognitive and neuropsychological symptoms after COVID-19 infection, in a longitudinal manner to see how the disease has affected their physical, psychological and cognitive function, their ability to be active, return to work, their health-related quality of life in correlation with potential diagnostic and prognostic markers., conditionsModule conditions: COVID-19, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Follow-up, outcomesModule primaryOutcomes measure: Change in cognitive functions measured with Mindmore and change in cognitive profile in Mindmore., primaryOutcomes measure: Symptom improvement in depression, primaryOutcomes measure: Self-reported symptom improvement in depression, primaryOutcomes measure: Grade of self-reported mental fatigue, primaryOutcomes measure: Rate of self-reported symptoms suggestive of post-traumatic stress disorder (PTSD), primaryOutcomes measure: Grade of self-reported stress, primaryOutcomes measure: Grade of self-reported cognitive failures in everyday life, secondaryOutcomes measure: Occurence of activity limitations and changes in health-related quality of life (QoL), secondaryOutcomes measure: Grade of work incapacity/sick leave and time to return to work, secondaryOutcomes measure: Changes in body size, secondaryOutcomes measure: Waist size, secondaryOutcomes measure: Rate of peak expiratory flow (PEF), secondaryOutcomes measure: Grade of physical exercise capacity, secondaryOutcomes measure: Concetration of Beta-Amyloid 42 in cerebrospinal fluid (CSF) as a CSF biomarker of neurodegeneration., secondaryOutcomes measure: Beta Amyloid Ratio 42/40 in cerebrospinal fluid (CSF) as a CSF biomarker of neurodegeneration linked to Alzheimer's disease, secondaryOutcomes measure: Concentration of neurogranin in cerebrospinal fluid (CSF) as a CSF biomarker of neurodegeneration linked to Alzheimer's disease, secondaryOutcomes measure: Concentration of Tau (P-Tau) protein in cerebrospinal fluid (CSF) as a CSF biomarker of cortikal damage/neurodegeneration, secondaryOutcomes measure: Concentration of phosphorylated Tau (P-Tau) in cerebrospinal fluid (CSF) as a CSF biomarker of neurodegeneration/taupathy, secondaryOutcomes measure: Concentration of neurofilament light (NFL) in cerebrospinal fluid (CSF) as a CSF biomarker of neurodegeneration, secondaryOutcomes measure: Concentration of neurofilament light (NFL) in plasma as a blood biomarker of neurodegeneration, secondaryOutcomes measure: Occurence of APOE4 allele as biomarker of genetic predisposition to Alzheimer's disease and susceptibility to more severe course of COVID-19 infection, secondaryOutcomes measure: Brain volumes and signal abnormalities in white and gray matter, secondaryOutcomes measure: Changes in functional and structural brain connectivity, secondaryOutcomes measure: Changes in gut microbiome, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Department of Geriatrics, University Hospital Örebro, status: RECRUITING, city: Örebro, country: Sweden, contacts name: Yvonne Freund-Levi, MD, PhD, role: CONTACT, phone: +46 736841130, email: yvonne.freund@oru.se, contacts name: Zbigniew Dzialanski, MD, role: SUB_INVESTIGATOR, geoPoint lat: 59.27412, lon: 15.2066, hasResults: False