protocolSection identificationModule nctId: NCT06283290, orgStudyIdInfo id: D3250R00122, briefTitle: PROPE Severe Asthma Study in Egypt, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-12, primaryCompletionDateStruct date: 2024-07-31, completionDateStruct date: 2024-07-31, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-04-19, sponsorCollaboratorsModule leadSponsor name: AstraZeneca, class: INDUSTRY, descriptionModule briefSummary: Asthma is a syndrome characterized by airway inflammation, reversible airway obstruction, and airway hyper-responsiveness. Patients present clinically with recurrent wheezing, shortness of breath, cough, and chest tightness. Asthma is a leading cause of morbidity with a global prevalence of approximately 300 million; it is estimated that the number of people with asthma may increase to 400 to 450 million people worldwide by 2025.Severe asthma is not considered a single disease; instead, it is divided into several phenotypes, owing to the variety of inflammatory, clinical, and functional characteristics that it can present with. One of the proposed and most studied phenotypes is severe eosinophilic asthma. Patients with severe asthma that is accompanied by a high concentration of eosinophils require greater healthcare resource use, greater disease management costs, and a much more impaired QoL than those who do not present with raised eosinophilia.While the number of targeted treatments for asthma management has been growing in recent years, the heterogeneity of clinical presentations, treatment responses, and inflammatory processes involved represent an added challenge for health care professionals. Thus, severe asthma management is a complex endeavor, and a thorough and up-to-date understanding of the pathophysiologic characteristics of the patient population promotes effective therapeutic decision-making.This cross-sectional, multicenter study aims to determine the prevalence of oral corticosteroid (OCS) use among severe asthma patients who attend to different sites specialized in the management of severe asthma across Egypt. In addition, the prevalence of eosinophilic phenotype of blood eosinophil count ≥ 150 cells/mm3, prevalence of atopic phenotype, and asthma control will also be studied., conditionsModule conditions: Severe Asthma, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 150, type: ESTIMATED, outcomesModule primaryOutcomes measure: To describe the prevalence (frequency) of OCS use among severe asthma patients as defined by chronic treatment and/or bursts of OCS use., secondaryOutcomes measure: To describe the demographic characteristics of severe eosinophilic asthma patients., secondaryOutcomes measure: To describe the clinical characteristics of severe eosinophilic asthma patients., secondaryOutcomes measure: To discover the average OCS dose per year used among severe asthma patients., secondaryOutcomes measure: To determine the prevalence of the eosinophilic phenotype, secondaryOutcomes measure: To determine the prevalence of the eosinophilic phenotype, secondaryOutcomes measure: To determine the prevalence of the total serum IgE, secondaryOutcomes measure: To determine the annual severe asthma exacerbation rate in the past twelve months among severe asthma patients in Egypt, secondaryOutcomes measure: To evaluate asthma control of severe asthma patients, secondaryOutcomes measure: To evaluate comorbidities related to OCS use, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Research Site, status: NOT_YET_RECRUITING, city: Mansoura, state: Dakahlia, country: Egypt, geoPoint lat: 31.03637, lon: 31.38069, locations facility: Research Site, status: RECRUITING, city: Zagazig, state: Sharkia, country: Egypt, geoPoint lat: 30.58768, lon: 31.502, locations facility: Research Site, status: RECRUITING, city: Alexandria, country: Egypt, geoPoint lat: 31.21564, lon: 29.95527, locations facility: Research Site, status: RECRUITING, city: Cairo, country: Egypt, geoPoint lat: 30.06263, lon: 31.24967, locations facility: Research Site, status: NOT_YET_RECRUITING, city: Cairo, country: Egypt, geoPoint lat: 30.06263, lon: 31.24967, hasResults: False