protocolSection identificationModule nctId: NCT06276400, orgStudyIdInfo id: 4-24-0023:1, briefTitle: LPFC Organization in Emotion-Duration Difference Estimation, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-29, primaryCompletionDateStruct date: 2028-03-31, completionDateStruct date: 2028-03-31, studyFirstPostDateStruct date: 2024-02-26, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: University of California, Santa Barbara, class: OTHER, descriptionModule briefSummary: To support optimal behavior in daily life, goals and responses following emotional events should ideally incorporate not only the valence and intensity of prior emotional episodes but also their temporal features, such as the relative duration of positive vs. negative attributes. However, how specific brain regions contribute to the integration of temporal and emotional information and promote goal-directed response remains unknown.The goal of this study is to examine how specific brain regions track both emotional and temporal information of dynamic emotional events to inform other related brain regions to guide goal-oriented and context-appropriate actions. The investigators will scan healthy human participants using functional MRI (fMRI) while they view emotional image sequences and track the associated emotional and temporal (duration) information, and act accordingly. The investigators will employ multivariate patterns analysis and pattern similarity analysis to identify brain regions that represent (can decode) emotion, time, and their combined signals, as well as brain regions that represent the associated action goal. In addition, to infer the causal contributions of these brain regions in forming task-relevant representations (emotion, time, and action goal), the same participants will be recruited to receive transcranial magnetic stimulation (TMS) in these regions., conditionsModule conditions: Healthy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: This is a basic science study in which all participants will participate in all task conditions within each experiment (repeated-measures design)., primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, maskingDescription: Participants will typically be unaware of the conditions presented, though because these involve manipulations of stimuli or task demands, they may be aware of the manipulation. This is not expected to impact the primary outcome measures (e.g., BOLD signal activation patterns)., enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Emotion valence, interventions name: Time, interventions name: TMS Stimulation, outcomesModule primaryOutcomes measure: Multivariate BOLD metrics, primaryOutcomes measure: Behavioral response, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: University of California, Santa Barbara, status: RECRUITING, city: Santa Barbara, state: California, zip: 93106, country: United States, geoPoint lat: 34.42083, lon: -119.69819, hasResults: False