protocolSection identificationModule nctId: NCT06366360, orgStudyIdInfo id: Piano-Neglect, briefTitle: Immersive Virtual Reality Treatment for Unilateral Spatial Neglect, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-11, primaryCompletionDateStruct date: 2026-09, completionDateStruct date: 2027-09, studyFirstPostDateStruct date: 2024-04-15, lastUpdatePostDateStruct date: 2024-04-16, sponsorCollaboratorsModule leadSponsor name: Hopitaux de Saint-Maurice, class: OTHER, descriptionModule briefSummary: Unilateral Spatial Neglect (USN) is a relatively common neuropsychological syndrome following stroke. It is characterized by difficulties in detecting, orienting and identifying events located in the hemispace contralateral to a brain lesion, unrelated to a primary motor or sensory disorder. Numerous methods have been developed for the rehabilitation of this syndrome. However, limitations in terms of efficacy are highlighted. These limitations may be linked to the fact that these methods are restricted to certain sensory modalities, thus failing to take into account the heterogeneity of the syndrome. Moreover, some patients' adherence to rehabilitation programs can also be complicated by motivational difficulties. Immersive Virtual Reality could help overcome these limitations. Indeed, it enables the introduction of new sensory modalities, notably auditory, to support a better apprehension of space.The main objective of this study is to determine the efficacy of an immersive virtual reality rehabilitation protocol based on musical practice in patients suffering from USN. This study also aims to explore the benefits of this rehabilitation protocol on patients' daily lives, as well as to explore the influence of patients' mood and motivation on the benefits of the immersive virtual reality rehabilitation protocol.To achieve these goals, patients will benefit from immersive virtual reality rehabilitation based on music practice. This rehabilitation will be compared to conventional USN rehabilitation. To this end, patients will be divided into two groups: classical rehabilitation only or classical rehabilitation and immersive virtual reality in parallel. Each patient will be randomly assigned to one of the two groups for a period of 2 weeks. Pre- and post-rehabilitation assessments will be provided., conditionsModule conditions: Stroke, conditions: Unilateral Spatial Neglect, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, interventionModelDescription: Each patient was assigned to a group that received 2 rehabilitations for 4 weeks, 1) both Immersive virtual reality therapy and a conventional rehabilitation first, and then conventional rehabilitation alone, or 2) A conventional rehabilitation alone and then both Immersive virtual reality therapy, and conventional rehabilitation., primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 80, type: ESTIMATED, armsInterventionsModule interventions name: Immersive Virtual Reality Intervention, interventions name: Conventional rehabilitation, outcomesModule primaryOutcomes measure: Bells Test, primaryOutcomes measure: Mesulam cancellation Task, primaryOutcomes measure: Bisection Test, primaryOutcomes measure: Copying Test, primaryOutcomes measure: Scene description Task, primaryOutcomes measure: Ecological scale of daily life activities, primaryOutcomes measure: Piano bisection Task, primaryOutcomes measure: Identifying the keys at the ends of the piano, primaryOutcomes measure: Virtual reality Bells Test, primaryOutcomes measure: Auditory Stimuli Localization Task in virtual reality, primaryOutcomes measure: Ecological virtual reality bisection task, primaryOutcomes measure: Virtual reality Baking Tray test, secondaryOutcomes measure: Mood assessment, secondaryOutcomes measure: Situational motivation questionnaire, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hôpitaux de Saint-Maurice, status: RECRUITING, city: Saint-Maurice, zip: 94410, country: France, contacts name: Secretary, role: CONTACT, phone: 01 43 96 68 22, phoneExt: +33, email: secretariat.ssrneuro@ght94n.fr, geoPoint lat: 48.82182, lon: 2.42716, hasResults: False