hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06387095, orgStudyIdInfo id: 2024/01/756, briefTitle: Efficacy of Parasternal Blocks in Cardiovascular Surgery Patients Undergoing Median Sternotomy, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-01, primaryCompletionDateStruct date: 2024-04-16, completionDateStruct date: 2025-08-01, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital, class: OTHER_GOV, descriptionModule briefSummary: Acute and chronic pain after cardiac surgery is a common problem that negatively affects quality of life. Postoperative pain after cardiac surgery is most intense in the first two days and decreases in the following period. However, postoperative pain with incomplete management in the acute period may become chronic. This may negatively affect the patient's quality of life. Although central blocks such as thoracic epidural and paravertebral blocks are considered the gold standard in analgesia control, the advantages of thoracic plan blocks, which are more superficial due to peroperative heparinisation; coagulation disorders; and procedural difficulties, are undeniable. Thoracic plane blocks, which can also be used in patients receiving anticoagulant and/or antiplatelet therapy, have recently been used for acute pain. The aim of this study was to evaluate the effect of thoracic plane blocks on extubation time, pain scores, intensive care unit (ICU) and hospital stays in patients undergoing median sternotomy., conditionsModule conditions: Postoperative Pain, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, interventionModelDescription: randomized controlled, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, whoMasked: INVESTIGATOR, enrollmentInfo count: 300, type: ESTIMATED, armsInterventionsModule interventions name: 1. no block, interventions name: 2. superficial parasternal block, interventions name: 3. deep parasternal block, outcomesModule primaryOutcomes measure: postoperative chronic pain, secondaryOutcomes measure: postoperative 24 hours acute pain, secondaryOutcomes measure: extubation time, secondaryOutcomes measure: icu time, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Kosuyolu High Education and Training Hospital, status: RECRUITING, city: Istanbul, state: Kartal, country: Turkey, contacts name: münire deniz, role: CONTACT, phone: +905556461015, email: muniredeniz.md@gmail.com, contacts name: ömer savluk, role: CONTACT, phone: +905056877440, email: dromersavluk@hotmail.com, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06387069, orgStudyIdInfo id: 2023-306-00CH1, briefTitle: A Study to Evaluate HMPL-306 in Patients With IDH1- and IDH2-mutated Acute Myeloid Leukemia, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-30, primaryCompletionDateStruct date: 2027-06-03, completionDateStruct date: 2028-06-29, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Hutchmed, class: INDUSTRY, descriptionModule briefSummary: An open-label design is adopted in this study. All patients will first undergo pre-screening to determine the mutation status of IDH, and all patients will be assigned to the registry study of the corresponding cohorts of IDH1 and IDH2 based on the pre-screening results. Patients with both IDH1 and IDH2 mutations will be enrolled in the IDH2 cohort. This study is divided into two cohorts. Cohort 1 includes R/R AML patients with IDH1-R132 mutations; Cohort 2 includes R/R AML patients with IDH2-R140 and R172 mutations. The two cohorts are designed independently and will be analyzed separately for statistical hypothesis testing. Patients in both cohorts will be randomized in a 1:1 ratio according to the central Interactive Web Response System (IWRS) into the test or control group, patients in the test group will receive HMPL-306 monotherapy at a dose of 250 mg once daily (QD) (Cycle 1, C1) + 150 mg QD \[starting from Cycle 2 (C2)\]. Patients in the control group will receive salvage chemotherapy (one of four options) consisting of two intensive chemotherapy regimens (MEC regimen and FLAG ± Ida regimen) and two non-intensive chemotherapy regimens (azacitidine and LoDAC), conditionsModule conditions: Acute Myeloid Leukemia, designModule studyType: INTERVENTIONAL, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 316, type: ESTIMATED, armsInterventionsModule interventions name: HMPL-306 Regimen, interventions name: Salvage Chemotherapy Regimen, outcomesModule primaryOutcomes measure: OS, secondaryOutcomes measure: CR rate, secondaryOutcomes measure: CR + CRh rate, secondaryOutcomes measure: CR + CRi + CRh rate, secondaryOutcomes measure: Assessments for PK (pharmacokinetics), secondaryOutcomes measure: Assessments for PK (pharmacokinetics), secondaryOutcomes measure: Duration of response (DOR), secondaryOutcomes measure: Transfusion-dependence conversion ratio, secondaryOutcomes measure: HSCT(hematopoietic stem cell transplantation) ratio, secondaryOutcomes measure: Safety, secondaryOutcomes measure: Quality of life (QoL), secondaryOutcomes measure: Time to response (TTR), secondaryOutcomes measure: EFS, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06387056, orgStudyIdInfo id: XMYY-2024KY040, briefTitle: Genomic Biomarker-guided Neoadjuvant Therapy for Prostate Cancer (SEGNO), acronym: SEGNO, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2026-04-01, completionDateStruct date: 2029-04-01, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: The First Affiliated Hospital of Xiamen University, class: OTHER, descriptionModule briefSummary: To evaluated the safety and efficacy of genomic biomarker-guided neoadjuvant therapy for locally advanced and oligometastatic prostate cancer., conditionsModule conditions: Locally Advanced Prostate Cancer, conditions: Oligometastatic Prostate Cancer, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Rezvilutamide, interventions name: Goserelin Microspheres for Injection, interventions name: Docetaxel, interventions name: Pamiparib, interventions name: Cisplatin, interventions name: Tislelizumab, outcomesModule primaryOutcomes measure: Rate of clinical complete response (cCR), primaryOutcomes measure: Rate of pathological minimal residual disease (pMRD), primaryOutcomes measure: Rate of complete pathologic response (pCR), secondaryOutcomes measure: Progression-free survival, secondaryOutcomes measure: Overall survival, eligibilityModule sex: MALE, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The First Affiliated Hospital of Xiamen University, status: RECRUITING, city: Xiamen, state: Fujian, zip: 361000, country: China, contacts name: Kaiyan Zhang, M.D., role: CONTACT, phone: +865922139714, email: zkyken@163.com, contacts name: Haichao Huang, M.D., role: CONTACT, phone: +865922139493, email: hhc_pku@163.com, geoPoint lat: 24.47979, lon: 118.08187, hasResults: False
protocolSection identificationModule nctId: NCT06387043, orgStudyIdInfo id: MS and Balance, briefTitle: Effects of Balance Exercises Performed With Different Visual Stimuli, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-12-01, primaryCompletionDateStruct date: 2025-03-01, completionDateStruct date: 2026-12-01, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Halic University, class: OTHER, collaborators name: Fenerbahce University, collaborators name: Biruni University, collaborators name: Istanbul University - Cerrahpasa (IUC), descriptionModule briefSummary: The study aims to examine the effects of balance exercises applied with different visual stimuli on individuals with MS., conditionsModule conditions: Multiple Sclerosis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: Balance exercises with Virtual Reality Glasses, interventions name: Balance Exercises with Stroboscopic Glasses, interventions name: Balance Exercises with Visual-Based Metaphor Training, interventions name: Traditional Balance Exercises, outcomesModule primaryOutcomes measure: Functional Near Infrared Ray Spectroscopy (fNIRS), primaryOutcomes measure: Timed Up and Go Test, primaryOutcomes measure: Functional Reach Test, primaryOutcomes measure: Berg Balance Scale, primaryOutcomes measure: Timed 25 Step Walking Test, secondaryOutcomes measure: Lower Extremity Motor Coordination Test, secondaryOutcomes measure: Fatigue Severity Scale, secondaryOutcomes measure: Quality of Life in Multiple Sclerosis Patients, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: Haliç University, city: Istanbul, state: Eyüpsultan, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06387017, orgStudyIdInfo id: RCAPHM22_0411, briefTitle: Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway, acronym: BIOCEPTION, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-02, primaryCompletionDateStruct date: 2028-07, completionDateStruct date: 2029-07, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Assistance Publique Hopitaux De Marseille, class: OTHER, descriptionModule briefSummary: Interventional study with minimal risks and constraints, with evaluation of the incidence of lung cancers by low-dose thoracic CT scan without injection of contrast medium, of the immunological, inflammatory and metabolic blood profile and of the microbiota; systematic proposal of smoking cessation for active smokers or assistance in maintaining cessation., conditionsModule conditions: Smoking-related Pathology, conditions: Atheroma, conditions: Non-progressive Cancer > 5 Years, conditions: Lung Cancer, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 750, type: ESTIMATED, armsInterventionsModule interventions name: blood sampling, interventions name: stool collection, interventions name: low dose CT scan, outcomesModule primaryOutcomes measure: biomarker group validation, secondaryOutcomes measure: Describe changes in biomarkers over time, secondaryOutcomes measure: Describe and compare biomarkers according to clinical characteristics of participants, secondaryOutcomes measure: Describe changes in quality of life over time, secondaryOutcomes measure: Describe changes in smoking habits over time, secondaryOutcomes measure: Describe changes in anxiety over time, secondaryOutcomes measure: Describe and compare biomarkers according to medical characteristics of participants, secondaryOutcomes measure: Describe and compare biomarkers according to geographic characteristics of participants, secondaryOutcomes measure: Describe and compare biomarkers according to socioeconomic characteristics of participants, eligibilityModule sex: ALL, minimumAge: 45 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Assistance Publique Hopitaux de Marseille, status: RECRUITING, city: Marseille, country: France, contacts name: David Boulate, role: CONTACT, email: david.boulate@ap-hm.fr, geoPoint lat: 43.29551, lon: 5.38958, hasResults: False
protocolSection identificationModule nctId: NCT06386991, orgStudyIdInfo id: 2024/206, briefTitle: Effect of Different Irrigation Solutions on Postoperative Pain and Lesion Healing, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2024-08-01, completionDateStruct date: 2026-01-01, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: TC Erciyes University, class: OTHER, descriptionModule briefSummary: In this study researchers plan to conduct, three different irrigation solutions that are responsible for the release of growth factors necessary for the success of regenerative endodontic treatments will be used. These solutions; Ethylene Diamine Tetra Acetic Acid (EDTA), Etidronic Acid and Citric Acid. The aim of this study is to evaluate the effect of different irrigation solutions used in regenerative endodontic treatment of necrotic open apex molar teeth on postoperative pain. Additionally, the healing of these teeth will be monitored for 1 year., conditionsModule conditions: Endodontic Disease, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 39, type: ESTIMATED, armsInterventionsModule interventions name: Using ethylenediaminetetraacetic acid (EDTA), citric acid ((MONO/ANH) and etidronic acid (HEBP) to clean root canals during regenerative endodontic treatments, outcomesModule primaryOutcomes measure: Determining and recording pain levels on the pain scale between treatment sessions, secondaryOutcomes measure: In the follow-up sessions after the treatment, the size of the lesion in the bone (mm2) is measured by radiography., eligibilityModule sex: ALL, minimumAge: 8 Years, maximumAge: 15 Years, stdAges: CHILD, contactsLocationsModule locations facility: Erciyes Üniversitesi Diş Hekimliği Fakültesi, status: RECRUITING, city: Kayseri, zip: 38039, country: Turkey, contacts name: ERASLAN AKYÜZ, role: CONTACT, phone: 4447138, phoneExt: 0352, email: ipekemamak@hotmail.com, contacts name: ÜSTÜN, role: CONTACT, phone: 4447138, phoneExt: 0352, email: yustun@erciyes.edu.tr, geoPoint lat: 38.73222, lon: 35.48528, hasResults: False
protocolSection identificationModule nctId: NCT06386978, orgStudyIdInfo id: 2024/209, briefTitle: Analgesic Efficacy of Transvers Abdominis Plane Block and Transversalis Fascia Plane Block in Cesarean Section, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-05-30, primaryCompletionDateStruct date: 2025-05-30, completionDateStruct date: 2026-05-30, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: TC Erciyes University, class: OTHER, descriptionModule briefSummary: This study was designed as a prospective, randomized observational clinical trial.A total of 90 adult women were included in the study performed elective cesarean section.After excluding patients, the care of 90 was included and 3 of these amounts were reserved.TAP Block Group (n=30,Group 1): Spinal Anesthesia + TAP block ; TFP Block group (n=30,Group 2): Spinal Anesthesia + TFP block ; Control group (n=30,Group 3); Spinal Anesthesia + No block;, conditionsModule conditions: Obstetric, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, enrollmentInfo count: 90, type: ESTIMATED, armsInterventionsModule interventions name: Transverse Facia Plane Block (TAP Block), interventions name: Transversalis Facia Plane Block (TFP Block), interventions name: Control, outcomesModule primaryOutcomes measure: VAS score evaluation, secondaryOutcomes measure: time until the first analgesic request, otherOutcomes measure: Satisfaction/Dissatisfaction, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 49 Years, stdAges: ADULT, contactsLocationsModule locations facility: Erciyes University, status: RECRUITING, city: Kayseri, zip: 38039, country: Turkey, contacts name: Kudret Dogru, Prof, role: CONTACT, phone: +905334735112, email: kdogru@erciyes.edu.tr, contacts name: Sibel Pehlivan, Asssoc Prof., role: CONTACT, phone: +905052532919, email: sibelpehlivan@erciyes.edu.tr, geoPoint lat: 38.73222, lon: 35.48528, hasResults: False
protocolSection identificationModule nctId: NCT06386965, orgStudyIdInfo id: 010.99/15, briefTitle: Sevoflurane Versus Propofol: Effect on Stress Response, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2024-03-05, primaryCompletionDateStruct date: 2024-06-05, completionDateStruct date: 2024-06-05, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Dr. Lutfi Kirdar Kartal Training and Research Hospital, class: OTHER_GOV, descriptionModule briefSummary: Stress is defined as hormonal and metabolic changes in the biological system that follow any injury. The stress response occurs as a general systemic response to injury and includes a wide range of endocrinological, immunological and hematological effects. The level of stress in the surgical process can affect not only the patients outcome but also the overall health system.The two main agents used in maintenance for general anesthesia are inhalation and intravenous anesthetics. Both inhalation anesthesia and TIVA (Total Intravenous Anesthesia) approaches provide general anesthesia suitable for surgical operations. However, the mechanisms of action of these two methods differ and are not fully understood.The aim of investigators' for this study was to investigate the effect of different anesthetic agents on stress inflammatory response in the preoperative, peroperative and postoperative periods., conditionsModule conditions: Propofol, conditions: Sevoflurane, conditions: Inflammatory Response, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: PROSPECTIVE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: taking blood sample, outcomesModule primaryOutcomes measure: compare inflammatory markers with sevolurane and propofol : glucose, WBC, procalcitonin, CRP, erytrocyte sedimentation rate, ferritin, pre albumin, albumin,tranferrin, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of Health Science, Kartal Dr Lutfi Kırdar Training and Researh Hospital, city: İstanbul, country: Turkey, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06386952, orgStudyIdInfo id: 02/2024-2025, briefTitle: To Compare People With T2DM Who Have Double Hump Versus Who do Not Have Double Hump, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-05-31, completionDateStruct date: 2025-06-30, studyFirstPostDateStruct date: 2024-04-26, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Diabetes Foundation, India, class: OTHER, collaborators name: National Diabetes Obesity and Cholesterol Foundation, descriptionModule briefSummary: Hypothesis: Double Hump in people with T2D is associated with higher magnitude of complication than people with single hump or no humpObjectives: To correlate single and double hump with diabetes complication T2DM patient will be recruited from endocrine OPD1. Clinical History and Examination:1. General Physical Examination: Height, weight, waist circumference, hip circumference, BMI, Blood Pressure, Hand grip. Buffalo Hump.2. Complications Assessment: Patient will be analyzed for:Micro Vascular(a) Diabetic retinopathy (i) Mild NPDR (ii) Mod NPDR (iii) Macular Edema / CSME (b) Neuropathy (Mild/Mod/Severe) (c) Chronic Kidney Disease (i) Micro/Macro albumin urea (ii) Increased Creatinine (iii) Decreased eGFRMacro Vascular1. Low ABI/PAD2. CVD-MI/PTCA/CABG/Heart Failure3. CVS-Stroke/ TIA/Carotid Blockage \>50%, conditionsModule conditions: Type 2 Diabetes Mellitus With Complication, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 200, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Double Hump increases diabetes complications, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Anoop misra, status: RECRUITING, city: New Delhi, state: Delhi, zip: 110048, country: India, contacts name: Anoop Misra, MD, role: CONTACT, phone: 01149101222, email: anoopmisra@gmail.com, contacts name: Koel Dutta, M.Sc, role: CONTACT, phone: 01149101222, email: koelduttac@gmail.com, contacts name: Anoop Misra, MD, role: PRINCIPAL_INVESTIGATOR, contacts name: Koel Dutta, M.Sc, role: SUB_INVESTIGATOR, geoPoint lat: 28.63576, lon: 77.22445, hasResults: False