protocolSection identificationModule nctId: NCT06285474, orgStudyIdInfo id: 22-001323, briefTitle: Investigating LIFUP in Anhedonic Depression, acronym: ILIAD, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2022-10-27, primaryCompletionDateStruct date: 2024-04-30, completionDateStruct date: 2024-04-30, studyFirstPostDateStruct date: 2024-02-29, lastUpdatePostDateStruct date: 2024-02-29, sponsorCollaboratorsModule leadSponsor name: University of California, Los Angeles, class: OTHER, collaborators name: Wellcome Trust, descriptionModule briefSummary: This study will observe changes in brain imaging, behavior, and symptom measures following intervention with low intensity focused ultrasound pulsation (LIFUP) targeting reward circuitry in individuals who are depressed and anhedonic., conditionsModule conditions: Depression, conditions: Anhedonia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: OTHER, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 46, type: ESTIMATED, armsInterventionsModule interventions name: Low Intensity Focused Ultrasound Pulsation (LIFUP), outcomesModule primaryOutcomes measure: Change in Patient health questionnaire-14 self report measure (PHQ-14) from baseline, primaryOutcomes measure: Change in Positive valence systems scale-21 self report measure (PVSS-21) from baseline, primaryOutcomes measure: Changes in MRI images from Pre-scan to week 5, primaryOutcomes measure: Change in Ecological momentary assessment (EMA) from W0/Baseline, secondaryOutcomes measure: Changes in digital behavioral phenotype sleep measurement, secondaryOutcomes measure: Changes in digital behavioral phenotype physical activity measurement, secondaryOutcomes measure: Changes in heart rate, secondaryOutcomes measure: Changes in heart rate variability, secondaryOutcomes measure: Changes in respiratory rate, secondaryOutcomes measure: changes in World Health Organization (WHO) -5 Wellbeing index score from W0/Baseline to end of study, secondaryOutcomes measure: changes in Pittsburgh Sleep Quality Index (PSQI) score from W0/Baseline to end of study, otherOutcomes measure: changes in Quick Inventory of Depressive Symptoms (QIDS-SR15) score from W0/Baseline to end of study, otherOutcomes measure: changes in Patient Health Questionnaire (PHQ-9) score from day 2 to week 2, otherOutcomes measure: changes in Brief Irritability Test (BITe) score from W0/Baseline to end of study, otherOutcomes measure: changes in Generalized Anxiety Disorder (GAD-7) score from W0/Baseline to end of study, otherOutcomes measure: Changes in Snaith Hamilton Pleasure Scale (SHAPS) score from W0/Baseline to end of study, otherOutcomes measure: Changes in Suicidal Ideation measure from Pre-scan to end of study, otherOutcomes measure: changes in Apathy Motivation Index (AMI) score from W0/Baseline to end of study, otherOutcomes measure: changes in Eudaimonic Well-Being Questionnaire (EWBQ) score from W0/Baseline to end of study, otherOutcomes measure: Changes in Work and Social Adjustment Scale (WSAS) score from W0/Baseline to end of study, otherOutcomes measure: Changes in Ruminative Response Scale (RRS) - brooding subscale score from W0/Baseline to end of study, otherOutcomes measure: changes in Trauma History Questionnaire (THQ) score from W0/Baseline to end of study, otherOutcomes measure: changes in Routines Survey from W0/Baseline to end of study, otherOutcomes measure: changes in USDA Housing and Food Insecurity score from W0/Baseline to end of study, otherOutcomes measure: changes in Holmes-Rahe Life Stress Survey score from W0/Baseline to end of study, otherOutcomes measure: Changes in emotion recognition accuracy scores from Pre-scan to end of study, otherOutcomes measure: Changes in emotion recognition response times from Pre-scan to end of study, otherOutcomes measure: Changes in continuous concentration accuracy scores from Pre-scan to end of study, otherOutcomes measure: Changes in continuous concentration response times from Pre-scan to end of study, otherOutcomes measure: Changes in continuous concentration error scores from Pre-scan to end of study, otherOutcomes measure: Changes in Apple Gathering task behavior from Pre-scan to end of study, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: University of California Los Angeles, city: Los Angeles, state: California, zip: 90095-1563, country: United States, geoPoint lat: 34.05223, lon: -118.24368, hasResults: False