hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06272071, orgStudyIdInfo id: 2023YFC2308802-01, briefTitle: A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of Severe Hepatitis (Liver Failure) Complicated With Infection, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2026-11, completionDateStruct date: 2026-11, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-03-04, sponsorCollaboratorsModule leadSponsor name: Zhejiang University, class: OTHER, collaborators name: Beijing Ditan Hospital, collaborators name: Beijing YouAn Hospital, collaborators name: Huashan Hospital, collaborators name: Qilu Hospital of Shandong University, descriptionModule briefSummary: The goal of this observational study is to expound the population and characteristics of pathogenic microorganisms with co-infection, draw the pedigree of pathogenic microorganisms, and evaluate its influence on disease outcome in patients with severe hepatitis (liver failure). The main questions it aims to answer are:* Mapping of infectious agents in patients with severe hepatitis (liver failure)* Constructing early warning predictive models to explore how to give an individualized regimen of integrated immune function., conditionsModule conditions: Liver Failure, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 2000, type: ESTIMATED, outcomesModule primaryOutcomes measure: Occurrence of secondary infections in patients with severe viral hepatitis (liver failure) at 4 weeks, including site of infection and pathogen of infection., primaryOutcomes measure: quick SEPSIS RELATED ORGAN FAILURE ASSESSMENT(qSOFA) at 4 weeks, secondaryOutcomes measure: Occurrence of secondary infections in patients with severe viral hepatitis (liver failure) at 8 weeks, including site of infection and pathogen of infection., secondaryOutcomes measure: Occurrence of secondary infections in patients with severe viral hepatitis (liver failure) at 12 weeks, including site of infection and pathogen of infection., secondaryOutcomes measure: qSOFA score at 8 weeks, secondaryOutcomes measure: qSOFA score at 12 weeks, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06272058, orgStudyIdInfo id: 1366-0034, briefTitle: A Study to Test How Avenciguat (BI 685509) is Taken up in the Body of People With and Without Liver Problems, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-20, primaryCompletionDateStruct date: 2024-10-01, completionDateStruct date: 2024-10-01, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-03-25, sponsorCollaboratorsModule leadSponsor name: Boehringer Ingelheim, class: INDUSTRY, descriptionModule briefSummary: This study is open to people with and without severe liver problems. People can join the study if they are 18 to 80 years of age and have a body mass index (BMI) between 18.5 and 42 kg/m2.Avenciguat (BI 685509) is a medicine that is being developed to treat high blood pressure in the portal vein (main vessel going to the liver). The purpose of this study is to find out whether having liver problems influences how Avenciguat (BI 685509) is taken up in the body. All participants take Avenciguat (BI 685509) once as a tablet.Participants are in the study for slightly longer than 1 month. Following the screening period of about 4 weeks, they stay at the study site for 4 nights. Afterwards, there are 2 visits to the study site. The site staff measures the amount of Avenciguat (BI 685509) in the blood. The doctors also regularly check participants' health and take note of any unwanted effects., conditionsModule conditions: Healthy, conditions: Liver Diseases, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 16, type: ESTIMATED, armsInterventionsModule interventions name: Avenciguat (BI 685509), outcomesModule primaryOutcomes measure: Area under the concentration-time curve of the analyte in plasma over the time interval from 0 to the last quantifiable data point (AUC0-tz), primaryOutcomes measure: Maximum measured concentration of the analyte in plasma (Cmax), secondaryOutcomes measure: Area under the concentration-time curve of the analyte in plasma over the time interval from 0 extrapolated to infinity (AUC0-∞), secondaryOutcomes measure: Occurrence of any treatment-emergent adverse event assessed as drug-related by the investigator, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Orlando Clinical Research Center, status: RECRUITING, city: Orlando, state: Florida, zip: 32809, country: United States, contacts name: Boehringer Ingelheim, role: CONTACT, phone: 833-602-2368, email: unitedstates@bitrialsupport.com, geoPoint lat: 28.53834, lon: -81.37924, hasResults: False
protocolSection identificationModule nctId: NCT06272019, orgStudyIdInfo id: HREC-DCU 2023-074, briefTitle: Alternative Application Methods of Pre-procedural Povidone Iodine Mouthrinse, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-09-01, primaryCompletionDateStruct date: 2024-04-20, completionDateStruct date: 2024-04-20, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Chulalongkorn University, class: OTHER, descriptionModule briefSummary: To compare the iodine remaining in saliva between gargle method and swab method, conditionsModule conditions: The Retention of Iodine in Saliva Over the Time, conditions: The Comparison of Iodine in Saliva Between Gargle and Swab, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, interventionModelDescription: the participant will use iodine gargle in 2 method, primaryPurpose: PREVENTION, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 25, type: ACTUAL, armsInterventionsModule interventions name: Iodine gargle, outcomesModule primaryOutcomes measure: The rate of retention of iodine in saliva, primaryOutcomes measure: The comparison of the retention of iodine between gargle and swab, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 30 Years, stdAges: ADULT, contactsLocationsModule locations facility: Faculty of Dentistry, Chulalongkorn University, city: Bangkok, country: Thailand, geoPoint lat: 13.75398, lon: 100.50144, hasResults: False
protocolSection identificationModule nctId: NCT06271993, orgStudyIdInfo id: 23-233, briefTitle: SPT for Sensitization of Collagen Dressing, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-08, primaryCompletionDateStruct date: 2024-02-16, completionDateStruct date: 2024-03-15, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-23, sponsorCollaboratorsModule leadSponsor name: Covalon Technologies Inc., class: INDUSTRY, collaborators name: ALS Beauty and Personal Care, descriptionModule briefSummary: The goal of this clinical trial is to determine the sensitization (contact allergy) potential of the test product ColActive Plus Collagen Matrix Dressing after a skin prick test on the skin of healthy human subjects. The main question it aims to answer is:• Does the product induce any sensitization (contact allergy) after a skin prick using a UniTest PC (pain control) device in healthy human subjects? Participants will have the test product and both positive and negative controls applied, and skin response will be evaluated by an allergist at 15 minutes, 6 hours, and 24-48 hours post-application to see if sensitization occurs., conditionsModule conditions: Allergy Skin, conditions: Allergic Skin Reaction, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: This will be a single center, with no randomization or blinding, study design in 20 healthy adult subjects, age 18-70 years. Based on prior experience approximately 30 subjects will be enrolled to ensure 20 subjects complete the study., primaryPurpose: OTHER, maskingInfo masking: NONE, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule interventions name: ColActivePlus Collagen Matrix Dressing, outcomesModule primaryOutcomes measure: Wheal measurement, primaryOutcomes measure: Wheal measurement, primaryOutcomes measure: Wheal measurement, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 70 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: ALS Beauty and Personal Care, status: RECRUITING, city: Torrance, state: California, zip: 90501, country: United States, contacts name: Ashley Glavis, BS, role: CONTACT, phone: 424-307-5900, email: ashley.glavis@alsglobal.com, contacts name: Jordan DeSantis, MHI, BS, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 33.83585, lon: -118.34063, hasResults: False
protocolSection identificationModule nctId: NCT06271980, orgStudyIdInfo id: 23228/ENCORE, briefTitle: Early-Onset Colorectal Cancer Recurrence, acronym: ENCORE, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-04-15, primaryCompletionDateStruct date: 2024-02-01, completionDateStruct date: 2024-02-01, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: City of Hope Medical Center, class: OTHER, collaborators name: IRCCS San Raffaele Hospital, Milan, Italy, collaborators name: Institute of Biomedical Research of Salamanca, Salamanca, Spain, descriptionModule briefSummary: Survivors of early-onset colorectal cancer (diagnosed before age 50) may experience colorectal cancer recurrence several years after curative-intent treatments, but clinical guidelines provide unclear guidance on endoscopic surveillance.This study aims to predict recurrence-free survival and overall survival, in survivors of early-onset colorectal cancer, using a tumor-based molecular assay based on microRNA (ribonucleic acid), conditionsModule conditions: Colorectal Cancer Recurrent, conditions: Colorectal Cancer, conditions: Colorectal Neoplasms, conditions: Colorectal Adenocarcinoma, conditions: Colorectal Cancer Stage I, conditions: Colorectal Cancer Stage II, conditions: Colorectal Cancer Stage III, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: RETROSPECTIVE, enrollmentInfo count: 177, type: ACTUAL, armsInterventionsModule interventions name: ENCORE, outcomesModule primaryOutcomes measure: Recurrence Free Survival, secondaryOutcomes measure: Overall Survival, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: City of Hope Medical Center, city: Duarte, state: California, zip: 91010, country: United States, geoPoint lat: 34.13945, lon: -117.97729, hasResults: False
protocolSection identificationModule nctId: NCT06271967, orgStudyIdInfo id: ABT-CIP-10518, briefTitle: [Trial of device that is not approved or cleared by the U.S. FDA], statusModule overallStatus: WITHHELD, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: [Redacted], hasResults: False
protocolSection identificationModule nctId: NCT06271941, orgStudyIdInfo id: HAPC-RCT, briefTitle: Prophylactic Double Thermal Ablation and Complete Closure After Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps: A Randomized Controlled Trial, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2027-10-01, completionDateStruct date: 2028-04-01, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Centre hospitalier de l'Université de Montréal (CHUM), class: OTHER, descriptionModule briefSummary: Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and/or adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. Recent studies have found that the use of hybrid argon plasma coagulation (h-APC) for the ablation of the margin and base of resection post-EMR could significantly reduce the recurrence rate, and complete closure of the post-EMR defect can prevent other adverse pre- and post-procedure outcomes such as bleeding.We hypothesize that performing hybrid argon plasma coagulation (h-APC) margin and base ablation post-EMR for large (≥20mm) colorectal LSLs will demonstrate a lower recurrence rate compared to Snare Tip Soft Coagulation (STSC) margin ablation. We also hypothesize that performing complete closure of the EMR defect will result in lower rates of adverse events compared to cases where no defect closure is performed., conditionsModule conditions: Colorectal Cancer, conditions: Polyp of Colon, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 892, type: ESTIMATED, armsInterventionsModule interventions name: Hybrid Argon Plasma Coagulation (h-APC), interventions name: Snare tip soft coagulation (STSC), outcomesModule primaryOutcomes measure: To compare the recurrence rates after EMR colorectal between the h-APC and SSTC methods, secondaryOutcomes measure: To assess the potential advantages associated with a complete defect closure, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Centre Hospitalier de l'Université de Montréal, city: Montréal, state: Quebec, country: Canada, geoPoint lat: 45.50884, lon: -73.58781, hasResults: False
protocolSection identificationModule nctId: NCT06271928, orgStudyIdInfo id: TJ-IRB20220634-yijingkeli, briefTitle: A Multicenter Clinical Study of Yijing Keli in the Treatment of Ovarian Aging, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-10-01, primaryCompletionDateStruct date: 2024-01-01, completionDateStruct date: 2025-01-01, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Tongji Hospital, class: OTHER, descriptionModule briefSummary: Ovarian aging (OA) seriously affects the physical and mental health of women. Nowadays, Chinese herbs have huge appeal and potential in treating OA. We have created a new Chinese herbal combination Yijing Keli, whereas its safety and efficacy still need to be validated. Hence, we will perform a population-based, multicenter study to confirm the safety and efficacy of Yijing Keli in therapy of OA. We aim to provide a solid evidence for TCM in therapy of OA., conditionsModule conditions: Ovarian Aging, designModule studyType: INTERVENTIONAL, phases: EARLY_PHASE1, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Yijing Keli, outcomesModule primaryOutcomes measure: the recovery rate of ovarian function, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, status: RECRUITING, city: Wuhan, country: China, contacts name: jinjin zhang, professor, role: CONTACT, phone: +8683663078, email: jinjinzhang@tjh.tjmu.edu.cn, contacts name: yan zhang, MD, role: CONTACT, phone: +8683663078, geoPoint lat: 30.58333, lon: 114.26667, hasResults: False
protocolSection identificationModule nctId: NCT06271915, orgStudyIdInfo id: cervical spine mobilization, briefTitle: Role of Cervical Spine Mobilization on Lateral Epicondylitis, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-15, primaryCompletionDateStruct date: 2024-05-15, completionDateStruct date: 2024-06-15, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-03-05, sponsorCollaboratorsModule leadSponsor name: Cairo University, class: OTHER, descriptionModule briefSummary: The study's primary goal is to examine the effectiveness of Mulligan's technique in reducing hyperalgesia in lateral epicondylitis, focusing on cervical spine, while also investigating its influence on central sensitization in relation to lateral epicondylitis., conditionsModule conditions: Lateral Epicondylitis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: SNAGs - eccentric exercise, outcomesModule primaryOutcomes measure: Leeds assessment of neuropathic symptoms and sign (LANSS) scale, primaryOutcomes measure: Pain-free hand grip test, secondaryOutcomes measure: The Numeric Rating Scale (NRS), eligibilityModule sex: ALL, minimumAge: 30 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: Outpatient physical therapy, Faculty of physical therapy, status: RECRUITING, city: Giza, zip: 2334, country: Egypt, contacts name: Ahmed ElMelhat, role: CONTACT, phone: 01112595022, email: ahmed.elmelhat@cu.edu.eg, geoPoint lat: 30.00808, lon: 31.21093, hasResults: False
protocolSection identificationModule nctId: NCT06271902, orgStudyIdInfo id: IRB-2023-531, briefTitle: Effects of the Singapore Youth Shoulder Overuse Injury Prevention Program Among Youth Volleyball Athletes in Singapore, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2024-06, completionDateStruct date: 2024-06, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Nanyang Technological University, class: OTHER, descriptionModule briefSummary: The Singapore Youth Shoulder Overuse Injury Prevention Program (YoSO-IPP) includes an exercise segment and an education segment. This study will (1) assess the effects of the exercise segment, and (2) assess the effects of the education segment among youth volleyball athletes using a randomized controlled trial over 12 weeks. Performance outcome measures of shoulder eccentric external rotation strength, shoulder internal rotation range of motion, and thoracic rotation range of motion will be used to assess the effects of the exercise segment. Knowledge scores via an online questionnaire will be used to assess the effects of the education segment.Hypothesis: The YoSO-IPP will have an effect on shoulder eccentric external rotation strength, shoulder internal rotation range of motion, and thoracic rotation range of motion and on knowledge scores., conditionsModule conditions: Sport Injury, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: This is a randomized controlled trial with an intervention group and a control group to evaluate the effects of the YoSO-IPP. The intervention group will perform the exercises and attend the online educational workshop. The control group will only perform lower body stretching exercises which is considered as a sham program., primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Singapore Youth Shoulder Overuse Injury Prevention Program, interventions name: Lower body stretching program, outcomesModule primaryOutcomes measure: Shoulder external rotation strength, primaryOutcomes measure: Internal rotation range of motion, primaryOutcomes measure: Thoracic rotation range of motion, primaryOutcomes measure: Knowledge of overuse injuries, secondaryOutcomes measure: Shoulder overuse injury prevalence, secondaryOutcomes measure: Elbow overuse injury prevalence, secondaryOutcomes measure: Shoulder overuse injury severity, secondaryOutcomes measure: Elbow overuse injury severity, eligibilityModule sex: ALL, minimumAge: 12 Years, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Nanyang Technological University, city: Singapore, country: Singapore, geoPoint lat: 1.28967, lon: 103.85007, hasResults: False
protocolSection identificationModule nctId: NCT06271889, orgStudyIdInfo id: B.10.1.TKH.4.34.H.GP.0.01/330, briefTitle: The Effect of Electro-fetal monıtorısıon Sound on Anxiety, paın and Postpartum Bonding at the First Phase of Delivery, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-11-24, primaryCompletionDateStruct date: 2024-02-24, completionDateStruct date: 2024-11-20, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Saglik Bilimleri Universitesi, class: OTHER, descriptionModule briefSummary: University of Health Sciences, Istanbul Umraniye training and Research Hospital, Clinic of Obstetrics and gynecology, birth, maternity and Child Health Hospital, Aydın to the clinic, pregnant women, pregnant women in active labor act, and received acceptance to delivery to the fetal heart sound by existing tripped; fetal heart sounds of pregnant women, anxiety, pain and the birth in order to determine the effect of connecting the end of the level will be conducted. The study will guide midwives in reducing the anxiety or pain of pregnant women., conditionsModule conditions: Delivery Fear, conditions: Labor Pain, conditions: Maternal-Fetal Relations, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized parallel controlled experimental design, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, maskingDescription: Which of the participants is the control or intervention group will be selected by randomization., whoMasked: PARTICIPANT, enrollmentInfo count: 128, type: ESTIMATED, armsInterventionsModule interventions name: Non-stress test, outcomesModule primaryOutcomes measure: VİSUAL ANALOG SCALE, primaryOutcomes measure: STATUS AND CONTINUOUS ANXIETY SCALE, otherOutcomes measure: Postpartum Attachment Scale (PASAS):, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 35 Years, stdAges: ADULT, contactsLocationsModule locations facility: Saglık Bilimleri Universitesi, status: RECRUITING, city: Istanbul, country: Turkey, contacts name: YASEMİN AYDIN KARTAL, role: CONTACT, phone: +90 5432870029, email: yasemin.aydin@sbu.edu.tr, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False