protocolSection identificationModule nctId: NCT06372301, orgStudyIdInfo id: 1-10-72-179-23, briefTitle: Dobutamine Stress Echocardiography in LF/LG Aortic Stenosis and Wild-type Transthyretin Amyloid Cardiomyopathy, acronym: DobAttrAS, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-02, primaryCompletionDateStruct date: 2025-11-01, completionDateStruct date: 2026-04-01, studyFirstPostDateStruct date: 2024-04-18, lastUpdatePostDateStruct date: 2024-04-18, sponsorCollaboratorsModule leadSponsor name: Steen Hvitfeldt Poulsen, class: OTHER, descriptionModule briefSummary: The goal of this prospective clinical study is improve the diagnosis of Low-flow low-gradient aortic stenosis (LF/LG AS), in patients with co-existing wild-type transthyretin cardiac amyloidosis (ATTRwt). The main question it aims to answer is whether the classic dobutamine-stress echocardiography can be used to determine AS severity in patients with ATTRwt and LF/LG AS This question will be tried to answer by comparing dobutamine stress echocardiography, with the invasively measured aortic valve area (which is considered as the gold standard).In addition we aim to assess the degree of myocardial fibrosis and amyloid infiltration, assessed by light microscopy and cardiac magnetic resonance (CMRI) and evaluation of myocyte mitochondrial function by high resolution respirometry and their relation to AS severity and hemodynamic response to dobutamine., conditionsModule conditions: Transthyretin Amyloid Cardiomyopathy, conditions: Aortic Stenosis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 24, type: ESTIMATED, armsInterventionsModule interventions name: Dobutamine stress echocardiography, outcomesModule primaryOutcomes measure: The correlation between echocardiography derived projected aortic valve area (AVAproj) and invasively assessed AVAproj under dobutamine infusion., secondaryOutcomes measure: Correlation between echocardiography derived AVA and invasively assessed AVA at rest and at different dobutamine infusion levels., secondaryOutcomes measure: Increase of SVI, LV ejection fraction and LV-global longitudinal strain of 10 % during maximal dobutamine stimulation., secondaryOutcomes measure: Correlation between echo- and invasive measured SVI., secondaryOutcomes measure: Degree of myocardial fibrosis, amyloid infiltration and mitochondrial dysfunction and its relation to AS severity and hemodynamic response to dobutamine, secondaryOutcomes measure: Reduction of mean pulmonary artery wedge pressure and/or mean pulmonary artery pressure by 10 %., secondaryOutcomes measure: Complication rate and symptomatic side effects during dobutamine challenge, eligibilityModule sex: ALL, minimumAge: 65 Years, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Department of Cardiology, Aarhus University Hospital, status: RECRUITING, city: Aarhus, zip: 8200, country: Denmark, contacts name: Ali Hussein Jaber Mejren, MD, role: CONTACT, phone: 0045 91 65 18 48, email: alimej@clin.au.dk, geoPoint lat: 56.15674, lon: 10.21076, hasResults: False