protocolSection identificationModule nctId: NCT06298097, orgStudyIdInfo id: 2019.11, briefTitle: Brain Connectivity Measured With High-density Electroencephalography, acronym: NEUROCONN, statusModule overallStatus: RECRUITING, startDateStruct date: 2020-06-11, primaryCompletionDateStruct date: 2025-02-02, completionDateStruct date: 2025-02-02, studyFirstPostDateStruct date: 2024-03-07, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: IRCCS San Camillo, Venezia, Italy, class: OTHER, descriptionModule briefSummary: Emerging scientific results show that disrupted functional connectivity in stroke can explain behavioral impairments and predict their recovery over time. However, no technique is yet available for widespread use in clinics to examine how neural synchronization in brain networks is altered in stroke patients. This is crucial to determine favorable prognostic factors and to define individualized rehabilitation protocols. Importantly, the investigators have successfully used high-density electroencephalography (hdEEG) in healthy individuals to measure neural synchronization in brain networks. In this project, the investigators will develop methods and tools based on hdEEG for assessing functional connectivity in stroke patients. These methods and tools will be employed to examine how neural changes occurring after brain lesions explain behavioral impairments. The project will open the way for the use of hdEEG at the patient's bedside, as a neurodiagnostic tool for stroke as well as other brain disorders., conditionsModule conditions: Stroke, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 170, type: ESTIMATED, armsInterventionsModule interventions name: Connectivity measures, outcomesModule primaryOutcomes measure: High-density electroencephalography measurements (work package 1, 2, and 3), primaryOutcomes measure: High-density electroencephalography measurements (work package 1, 2, and 3), primaryOutcomes measure: High-density electroencephalography measurements (work package 1, 2, and 3), primaryOutcomes measure: High-density electroencephalography measurements (work package 1, 2, and 3), primaryOutcomes measure: High-density electroencephalography measurements (work package 1, 2, and 3), primaryOutcomes measure: Magnetic Resonance Imaging measurement (work package 1, 2, and 3), primaryOutcomes measure: Magnetic Resonance Imaging measurement (work package 1, 2, and 3), primaryOutcomes measure: Magnetic Resonance Imaging measurement (work package 1, 2, and 3), primaryOutcomes measure: Magnetic Resonance Imaging measurement (work package 1, 2, and 3), primaryOutcomes measure: Magnetic Resonance Imaging measurement (work package 1, 2, and 3), secondaryOutcomes measure: Muscle strength measurement (work package 3), secondaryOutcomes measure: Muscle strength measurement (work package 3), secondaryOutcomes measure: Muscle strength measurement (work package 3), secondaryOutcomes measure: Muscle strength measurement (work package 3), secondaryOutcomes measure: Muscle strength measurement (work package 3), secondaryOutcomes measure: Sensorimotor impairment measurement (work package 3), secondaryOutcomes measure: Sensorimotor impairment measurement (work package 3), secondaryOutcomes measure: Sensorimotor impairment measurement (work package 3), secondaryOutcomes measure: Sensorimotor impairment measurement (work package 3), secondaryOutcomes measure: Sensorimotor impairment measurement (work package 3), secondaryOutcomes measure: Spasticity measurement (work package 3), secondaryOutcomes measure: Spasticity measurement (work package 3), secondaryOutcomes measure: Spasticity measurement (work package 3), secondaryOutcomes measure: Spasticity measurement (work package 3), secondaryOutcomes measure: Spasticity measurement (work package 3), secondaryOutcomes measure: Funtional skills measurement (work package 3)., secondaryOutcomes measure: Funtional skills measurement (work package 3)., secondaryOutcomes measure: Funtional skills measurement (work package 3)., secondaryOutcomes measure: Funtional skills measurement (work package 3)., secondaryOutcomes measure: Funtional skills measurement (work package 3)., secondaryOutcomes measure: Activities of daily living measurement (work package 3), secondaryOutcomes measure: Activities of daily living measurement (work package 3), secondaryOutcomes measure: Activities of daily living measurement (work package 3), secondaryOutcomes measure: Activities of daily living measurement (work package 3), secondaryOutcomes measure: Activities of daily living measurement (work package 3), secondaryOutcomes measure: Pain measurement (work package 3), secondaryOutcomes measure: Pain measurement (work package 3), secondaryOutcomes measure: Pain measurement (work package 3), secondaryOutcomes measure: Pain measurement (work package 3), secondaryOutcomes measure: Pain measurement (work package 3), secondaryOutcomes measure: Cognitive performance measurements (work package 3), secondaryOutcomes measure: Cognitive performance measurements (work package 3), secondaryOutcomes measure: Cognitive performance measurements (work package 3), secondaryOutcomes measure: Cognitive performance measurements (work package 3), secondaryOutcomes measure: Cognitive performance measurements (work package 3), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: IRCCS San Camillo Hospital, status: RECRUITING, city: Venice, country: Italy, contacts role: CONTACT, email: n.ricercaclinica@hsancamillo.it, geoPoint lat: 45.43713, lon: 12.33265, hasResults: False