protocolSection identificationModule nctId: NCT06317896, orgStudyIdInfo id: 2024-KY-048-01, briefTitle: Value of Dynamic Monitoring of Early Recurrence of Hepatocellular Carcinoma After Radical Resection Based on CTCS, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2026-12-31, completionDateStruct date: 2026-12-31, studyFirstPostDateStruct date: 2024-03-19, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: Zhujiang Hospital, class: OTHER, descriptionModule briefSummary: On the basis of previous retrospective studies, the Task Force will further optimize the CTCs longitudinal surveillance model and initially validate the subclonal origin (CTC-DNA) of recurrent/metastatic foci derived from CTCs at the molecular level in hepatocellular carcinoma, prospective clinical trials will be conducted to further validate the predictive value of the CTCS longitudinal monitoring model in predicting postoperative recurrence of hepatocellular carcinoma, and to verify whether it is earlier than imaging to indicate recurrence, to explore the clinical feasibility of CTCs in guiding postoperative adjuvant therapy of liver cancer, and to provide new ideas for early intervention strategy of liver cancer after operation, to establish a set of standardized clinical scheme of auxiliary treatment for patients with liver cancer after operation for accurate and individualized"Early diagnosis and treatment"., conditionsModule conditions: Hepatocellular Carcinoma, conditions: Circulating Tumor Cell, conditions: Recurrence, conditions: Surgery, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 82, type: ESTIMATED, armsInterventionsModule interventions name: circulating tumor cells, outcomesModule primaryOutcomes measure: 2-year recurrence-free survival rate, secondaryOutcomes measure: Correlation between CTCs status dynamic changes and relapse, secondaryOutcomes measure: Correlation between metastasis，primary tumor and CTCs in blood through NGS and CTC-DNA, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The Sixth Affiliated Hospital of South China University of Technology, city: Foshan, state: Guangdong, country: China, contacts name: Weichao Liang, Prof., role: CONTACT, phone: 13590542927, contacts name: Weichao Liang, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 23.02677, lon: 113.13148, locations facility: Zhujiang Hospital of Southern Medical University, city: Guangzhou, state: Guangdong, zip: 510220, country: China, contacts name: Mingxin Pan, Prof., role: CONTACT, phone: +8618928918216, email: pmxwxy@sohu.com, contacts name: Zhoubin Feng, role: CONTACT, phone: 19830551997, email: Fzbin1001@163.com, contacts name: Mingxin Pan, Prof., role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 23.11667, lon: 113.25, locations facility: Affiliated Cancer Hospital and Institute of Guangzhou Medical University, city: Guangzhou, state: Guangdong, country: China, contacts name: Yinbing Wu, Prof., role: CONTACT, phone: 18620007296, contacts name: Yinbing Wu, role: PRINCIPAL_INVESTIGATOR, geoPoint lat: 23.11667, lon: 113.25, hasResults: False