protocolSection identificationModule nctId: NCT06374108, orgStudyIdInfo id: Neuro_Exercise, briefTitle: Resistance Training and Corticospinal Excitability in Multiple Sclerosis, acronym: NEXIMS, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2025-12-31, completionDateStruct date: 2026-05-31, studyFirstPostDateStruct date: 2024-04-18, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: University of Aarhus, class: OTHER, collaborators name: Aarhus University Hospital, collaborators name: University of Copenhagen, descriptionModule briefSummary: The goal of the present study is to investigate effects of progressive resistance training on central nervous system functioning (corticospinal excitability (CSE)) and walking capacity in persons with multiple sclerosis (pwMS). A total of 54 pwMS will be enrolled and randomized into 1 of 3 groups: high dose resistant training (RT), low dose RT, and waitlist control., conditionsModule conditions: Multiple Sclerosis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 54, type: ESTIMATED, armsInterventionsModule interventions name: Progressive resistance training, outcomesModule primaryOutcomes measure: MEP/Mmax ratio, secondaryOutcomes measure: Muscle strength, secondaryOutcomes measure: Voluntary activation I, secondaryOutcomes measure: Voluntary activation II, secondaryOutcomes measure: Force Steadiness, secondaryOutcomes measure: Rate of Force Developement, secondaryOutcomes measure: Ultrasound, secondaryOutcomes measure: Resting Motor Threshold (rMT), secondaryOutcomes measure: Active Motor Threshold (aMT), secondaryOutcomes measure: MEP latency (resting), secondaryOutcomes measure: MEP latency (active), secondaryOutcomes measure: MEP amplitude (resting), secondaryOutcomes measure: MEP amplitude (active), secondaryOutcomes measure: Short-interval intracortical Inhibition (SICI), secondaryOutcomes measure: Intracortical facilitation (ICF), secondaryOutcomes measure: Cortical Silent Period (CSP), secondaryOutcomes measure: Central Motor Conduction Time (CMCT), secondaryOutcomes measure: EEG-EMG coherence (0-1), secondaryOutcomes measure: Timed 25 feet walk test (T25FWT), secondaryOutcomes measure: 6-minute walk test (6MWT), secondaryOutcomes measure: Six spot step test (SSST), secondaryOutcomes measure: 5 sit-to-stand (5STS), secondaryOutcomes measure: 9-step stair ascend (9SSA), secondaryOutcomes measure: Patient determined disease steps (PDDS), secondaryOutcomes measure: Multiple Sclerosis Walking Scale (MSWS), secondaryOutcomes measure: Modified fatigue impact scale (MFIS), secondaryOutcomes measure: MS impact scale (MSIS), secondaryOutcomes measure: Falls-efficacy scale - international (FES-1), secondaryOutcomes measure: The Physical Activity Enjoyment Scale (PACES), secondaryOutcomes measure: Brief pain inventory (BPI), secondaryOutcomes measure: Baecke physical activity, secondaryOutcomes measure: Accelerometry, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False