protocolSection identificationModule nctId: NCT06279507, orgStudyIdInfo id: PMK-00007, briefTitle: Efficacy of Hyaluronic Acid Injection in Knee Osteoarthritis, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-10, primaryCompletionDateStruct date: 2025-01-31, completionDateStruct date: 2025-06-30, studyFirstPostDateStruct date: 2024-02-28, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Phramongkutklao College of Medicine and Hospital, class: OTHER, collaborators name: Chulalongkorn University, collaborators name: Khon Kaen University, collaborators name: Police General Hospital, descriptionModule briefSummary: The aim of this clinical trial study is to compare the efficacy of Hyaluronic injection in patients with symptomatic knee osteoarthritis. The main questions it aims to answer are:* Is Hyaluronic acid injection improve pain symptom, joint stiffness, and joint function in patients with knee osteoarthritis* Is Hyaluronic acid injection improve knee performance status and health-related quality of life in patients with knee osteoarthritisParticipants will be allocated to receive one treatments; either Hyaluronic acid or normal saline injections after receiving glucocorticoid injection.Researchers will compare the Hyaluronic acid with normal saline injection to see if the former show superior effect in terms of pain, joint stiffness, function, as well as health-related quality of life comparing with placebo., conditionsModule conditions: Knee Osteoarthritis, conditions: Pain, Joint, conditions: Stiffness of Knee, Not Elsewhere Classified, conditions: Quality of Life, designModule studyType: INTERVENTIONAL, phases: PHASE4, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: The participants would be allocated into one treatment group;* Intervention group : Hyaluronic acid injection* Placebo group : Normal saline, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, maskingDescription: Participants will not know what treatment they receive. Co-investigators will not know what the participants are injected. Outcome assessor will not know which treatment participant receive., whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 176, type: ESTIMATED, armsInterventionsModule interventions name: Sodium Hyaluronate, interventions name: Normal Saline, interventions name: Triamcinolone Acetonide 10mg/mL, outcomesModule primaryOutcomes measure: Pain outcome measurement, primaryOutcomes measure: Joint stiffness and function measurement, primaryOutcomes measure: Overall symptom assessment, secondaryOutcomes measure: Knee performance evaluation, secondaryOutcomes measure: Quality of life assessment, eligibilityModule sex: ALL, minimumAge: 50 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Phramongkutklao Hospital, status: RECRUITING, city: Bangkok, zip: 10400, country: Thailand, contacts name: Suthee Panichkul, role: CONTACT, phone: 6623547600, phoneExt: 93681, email: suthee99@yahoo.com, geoPoint lat: 13.75398, lon: 100.50144, hasResults: False