hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06306677, orgStudyIdInfo id: SH9H-2023-T369-1, briefTitle: Accuracy of an AI-clinical Knowledge-based Hybrid System for Detecting Periodontitis in OPG Images, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-12, primaryCompletionDateStruct date: 2024-08-01, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-03-13, sponsorCollaboratorsModule leadSponsor name: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, class: OTHER, collaborators name: ShanghaiTech University, collaborators name: University of Roma La Sapienza, collaborators name: The University of Hong Kong, descriptionModule briefSummary: Periodontitis is highly prevalent and rarely detected and treated in the earlier stages of the disease. Orthopantomography (OPG) is the most frequently taken dental radiograph around the world, and its systematic screening may contribute to early detection of periodontitis and access to the needed level of care. The investigators' recent study initially developed an AI-clinical knowledge-based system for automatic periodontitis diagnosis and indicated good performance for differentiating stage II-IV periodontitis. This cross-sectional diagnostic study aims to compare the diagnostic accuracy of this AI-clinical knowledge-based hybrid system (Index test) with human experts (reference test) for differentiating stage II-IV periodontitis using the OPG images obtained from different 4 centers around the world., conditionsModule conditions: Periodontitis, conditions: Periodontal Diseases, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 1200, type: ESTIMATED, armsInterventionsModule interventions name: AI-clincial-based hybrid system for radiographic image analysis, outcomesModule primaryOutcomes measure: Sensitivity measure, primaryOutcomes measure: Specificity measure, primaryOutcomes measure: The area under the receiver operating characteristic curve (AUC) measure, primaryOutcomes measure: Diagnostic accuracy, secondaryOutcomes measure: Assessment time, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Shanghai Perio-Implant Innovation Center, status: RECRUITING, city: Shanghai, state: Shanghai, zip: 201206, country: China, contacts name: Yuan Li, role: CONTACT, phone: 13916337473, email: ly9919@hotmail.com, geoPoint lat: 31.22222, lon: 121.45806, locations facility: Prince Philip Dental Hospital, status: RECRUITING, city: Hong Kong, country: Hong Kong, contacts name: George Pelekos, role: CONTACT, email: george74@hku.hk, geoPoint lat: 22.27832, lon: 114.17469, locations facility: La Sapienza Dental School, status: RECRUITING, city: Roma, country: Italy, contacts name: Lorenzo Marini, role: CONTACT, email: lorenzo.marini@uniroma1.it, geoPoint lat: 41.89193, lon: 12.51133, hasResults: False
protocolSection identificationModule nctId: NCT06306664, orgStudyIdInfo id: PT.REC/012/004881, briefTitle: Effect of Two Different Modes of Polarized Polychromatic Non-coherent Light Therapy on Jumper's Knee, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2025-11-29, completionDateStruct date: 2025-12-01, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: Cairo University, class: OTHER, descriptionModule briefSummary: The purposes of this study are:1. To examine the combined effects of Yellow CPPNLT and conventional treatment on pain intensity, pain pressure threshold, functional disability, and muscle strength in athletic jumper knee.2. To examine the combined effects of Green CPPNLT and conventional treatment on pain intensity, pain pressure threshold, functional disability, and muscle strength in athletic jumper knee.3 3- To compare between the effects of Yellow CPPNLT and Green CPPNLT on pain intensity, pain pressure threshold, functional disability, and muscle strength in athletic jumper knee., conditionsModule conditions: Jumper's Knee, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: double, whoMasked: PARTICIPANT, enrollmentInfo count: 60, type: ACTUAL, armsInterventionsModule interventions name: Bioptron, interventions name: Placebo Comparator, outcomesModule primaryOutcomes measure: Pain (Visual analogue scale)., primaryOutcomes measure: pain intensity (Pressure algometry), primaryOutcomes measure: Disability questionnaire (Victorian institute of sport assessment-patella)., primaryOutcomes measure: Muscle strength (Hand held dynamometer), otherOutcomes measure: Muscle strength and endurance ( Biodex-Isokinetic Dynamometer), eligibilityModule sex: ALL, minimumAge: 15 Years, maximumAge: 35 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule locations facility: Physical Therapy, city: Giza, state: Dokki, zip: 12612, country: Egypt, geoPoint lat: 30.00808, lon: 31.21093, hasResults: False
protocolSection identificationModule nctId: NCT06306651, orgStudyIdInfo id: FMASU MD283/2023, briefTitle: High Flow Nasal Cannula and Conventional Oxygen Therapy in the Postoperative Management of Patients With Mild to Moderate Obstructive Sleep Apnea, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-16, primaryCompletionDateStruct date: 2025-03-01, completionDateStruct date: 2025-03-01, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-03-19, sponsorCollaboratorsModule leadSponsor name: Ain Shams University, class: OTHER, descriptionModule briefSummary: This study aims to compare the effectiveness of conventional oxygen therapy oxygen and high-flow nasal cannula therapy on oxygen saturation (SpO2), measuring number of SpO2 drop \>4% of base line oxygen saturation (o2 desaturation index), length of the ICU stay, and the need of use supplemental continuous positive airway pressure (CPAP) support in any of the study groups in the postoperative ICU setting., conditionsModule conditions: High Flow Nasal Cannula, conditions: Obstructive Sleep Apnea, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: High flow nasal cannula therapy group, interventions name: Conventional oxygen therapy group, outcomesModule primaryOutcomes measure: Oxygen desaturation index, secondaryOutcomes measure: The length of Intensive care unit stay, secondaryOutcomes measure: The incidence of ventilatory support, eligibilityModule sex: ALL, minimumAge: 21 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule locations facility: Ain Shams University, status: RECRUITING, city: Cairo, zip: 11591, country: Egypt, contacts name: Omar M Mohamed, Master, role: CONTACT, phone: 00201063190923, email: omarmedhat0100565@med.asu.edu.eg, contacts name: Bahaa A Ali, MD, role: SUB_INVESTIGATOR, contacts name: Adel M Alansary, MD, role: SUB_INVESTIGATOR, contacts name: Nora M Mahmoud, MD, role: SUB_INVESTIGATOR, contacts name: Mohamed M Abdallah, MD, role: SUB_INVESTIGATOR, geoPoint lat: 30.06263, lon: 31.24967, hasResults: False
protocolSection identificationModule nctId: NCT06306612, orgStudyIdInfo id: IIT-2023-0165, briefTitle: CytoREductive prostAtectomy for Poly-metastatic Hormone sensiTIVE Prostate Cancer, acronym: CREATIVE, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-21, primaryCompletionDateStruct date: 2028-12-31, completionDateStruct date: 2028-12-31, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-04-10, sponsorCollaboratorsModule leadSponsor name: RenJi Hospital, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to compare systemic therapy combined with cytoreductive prostatectomy with standard of care (SOC) in de novo poly-metastatic hormone sensitive prostate cancer (de novo pmHSPC). The main questions it aims to answer are:1. To explore the clinical benefit and safety of systemic therapy combined with cytoreductive prostatectomy for patients with de novo pmHSPC.2. To explore the characteristics of the subgroup of patients who could benefit more from the above treatment.3. To explore the relationship between stage efficacy and clinical prognosis.4. To explore the correlation between molecular imaging such as PSMA-PET/CT and its changes with treatment efficacy.Participants will undergo systemic therapy combined with cytoreductive prostatectomy.Researchers will compare systemic therapy combined with cytoreductive prostatectomy with SOC to see the pros and cons of the two strategies., conditionsModule conditions: Prostate Cancer, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 192, type: ESTIMATED, armsInterventionsModule interventions name: Systemic Chemohormonal Therapy, interventions name: Systemic Hormonal Therapy, interventions name: Cytoreductive Prostatectomy, interventions name: Postoperative Adjuvant Radiotherapy, outcomesModule primaryOutcomes measure: Castration resistant-free survival, secondaryOutcomes measure: Overall Survival, secondaryOutcomes measure: PSA response, secondaryOutcomes measure: Symptomatic skeletal event, secondaryOutcomes measure: Pain progression, secondaryOutcomes measure: Deterioration of disease-related somatic symptoms, eligibilityModule sex: MALE, minimumAge: 18 Years, maximumAge: 85 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Renji Hospital, Shanghai Jiao Tong University School of Medicine, status: RECRUITING, city: Shanghai, state: Shanghai, zip: 200127, country: China, contacts name: Liang Dong, Dr., role: CONTACT, phone: +86-13601613536, email: drdongliang@126.com, contacts name: Yinjie Zhu, Dr., role: PRINCIPAL_INVESTIGATOR, contacts name: Liang Dong, Dr., role: PRINCIPAL_INVESTIGATOR, contacts name: Ruohua Chen, Dr., role: SUB_INVESTIGATOR, contacts name: Xinxing Du, Dr., role: SUB_INVESTIGATOR, contacts name: Yanhao Dong, Dr., role: SUB_INVESTIGATOR, contacts name: Hanjing Zhu, role: SUB_INVESTIGATOR, geoPoint lat: 31.22222, lon: 121.45806, hasResults: False
protocolSection identificationModule nctId: NCT06306599, orgStudyIdInfo id: Thyroid AI US operator exp, briefTitle: Ultrasound Operator Influence on Diagnostics With AI for Thyroid Nodules - Clinial Trial, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-09-01, primaryCompletionDateStruct date: 2023-11-04, completionDateStruct date: 2023-11-04, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: Rigshospitalet, Denmark, class: OTHER, descriptionModule briefSummary: This is a prospective clinical study aiming to test how the experience of the ultrasound operator influences the performance of AI-based (artificial intelligence-based) diagnostics when analysing thyroid nodules on ultrasound scans. The investigators set up an experiment with five stations, each with a patient with a thyroid nodule and an ultrasound machine with the deep learning based system S-Detect for Thyroid installed. 20 study participants where recruited: 8 medical students of novice ultrasound skill, 3 junior ENT (ear-nose-throat) registrars of intermediate ultrasound skill, and 9 senior ENT registrars experienced in ultrasound. The participants scanned all the patients and recorded their analyses of the nodules using the EUTIRADS (European thyroid imagining reporting and data system) system in three different ways: a analysis of their own, S-Detect's analysis, and an analysis combining the two previous.The hypothesis was that the AI system would perform equally well when between the participant groups. In addition, it was expected that the experienced participants would perform better than the students without AI help, and that the doctors would gain little from AI input, but that the students would have their performance improved by AI input., conditionsModule conditions: Thyroid Nodule, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, interventionModelDescription: 20 participants scan five patients over the course of fours hour and collect their diagnostics analyses on paper forms., primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ACTUAL, armsInterventionsModule interventions name: S-Detect for Thyroid, outcomesModule primaryOutcomes measure: Accuracy of S-Detect diagnosis, secondaryOutcomes measure: Accuracy of biopsy recommendation, secondaryOutcomes measure: Nodule classification agreement, secondaryOutcomes measure: Accuracy of EUTIRADS scores, secondaryOutcomes measure: Nodule measurement, secondaryOutcomes measure: OSAUS score, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Rigshospitalet, city: Copenhagen, zip: 2100, country: Denmark, geoPoint lat: 55.67594, lon: 12.56553, hasResults: False
protocolSection identificationModule nctId: NCT06306586, orgStudyIdInfo id: 639031, briefTitle: A Digital Treatment for Adolescents With Eating Disorders, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-05, primaryCompletionDateStruct date: 2026-01-01, completionDateStruct date: 2026-01-01, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-04-03, sponsorCollaboratorsModule leadSponsor name: Haukeland University Hospital, class: OTHER, collaborators name: Helse Fonna, descriptionModule briefSummary: The goal of this feasibility study is to evaluate the feasibility and preliminary clinical outcomes of a personalized digital treatment for adolescents with eating disorders. The main objectives are to:i) Evaluate whether a personalized digital treatment for adolescents with eating disorders are feasible in a child and adolescent psychiatric outpatient clinic.ii) Evaluate who benefits from a personalized digital treatment for adolescents with eating disorders (what works for whom?) iii) Evaluate the cost-benefit of a personalized digital treatment for adolescents with eating disorders.Participants will be enrolled in a 10-week digital treatment including weekly therapist contact. They will be asked to complete self-report questionnaires at pre-, during, post- and 3- and 6-months follow-up., conditionsModule conditions: Eating Disorders, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Digital Treatment for Adolescents With Eating Disorders, outcomesModule primaryOutcomes measure: The Credibility and Expectancy Scale (CEQ-1), primaryOutcomes measure: Adherence, primaryOutcomes measure: Module evaluations, primaryOutcomes measure: Client Satisfaction Questionnaire (CSQ-3), primaryOutcomes measure: Recruitment, primaryOutcomes measure: Eating disorder symptoms, primaryOutcomes measure: The Clinical Impairment Assessment Questionnaire (CIA), primaryOutcomes measure: The KIDSCREEN (KIDSCREEN-10), secondaryOutcomes measure: The Patient Health Questionnaire (PHQ-2), secondaryOutcomes measure: Generalized Anxiety Disorder scale (GAD-2), secondaryOutcomes measure: School attendance, secondaryOutcomes measure: Tme with friends, secondaryOutcomes measure: Difficulties with Emotion Regulation Scale (DERS-18), secondaryOutcomes measure: EuroQoL 5D-5L (EQ-5D-5L), otherOutcomes measure: The Rosenberg Self-Esteem Scale (RSES), otherOutcomes measure: The readiness to change questionnaire (RTCQ-6), otherOutcomes measure: Qualitative interviews, eligibilityModule sex: ALL, minimumAge: 16 Years, maximumAge: 18 Years, stdAges: CHILD, stdAges: ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06306573, orgStudyIdInfo id: CL1019613, briefTitle: CardioMEMS HF System Real-World Evidence Post-Approval Study, statusModule overallStatus: ENROLLING_BY_INVITATION, startDateStruct date: 2022-12-15, primaryCompletionDateStruct date: 2027-12-31, completionDateStruct date: 2028-12-31, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: Abbott Medical Devices, class: INDUSTRY, descriptionModule briefSummary: The purpose of this post-approval study (PAS) is to evaluate the long-term safety and effectiveness of the CardioMEMS™ HF System using real-world evidence (RWE) methods., conditionsModule conditions: Heart Failure NYHA Class II, conditions: Heart Failure NYHA Class III, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 2500, type: ESTIMATED, armsInterventionsModule interventions name: CardioMEMS HF System, outcomesModule primaryOutcomes measure: Two-Year Survival in the Primary Cohort (NYHA Class II subjects), secondaryOutcomes measure: Two-Year Survival in the Full Cohort (NYHA Class II and Class III subjects), otherOutcomes measure: 3-Year Survival, otherOutcomes measure: HF Hospitalization Rate, otherOutcomes measure: Pulmonary Artery (PA) Pressures Measured by the CardioMEMS PA Sensor, otherOutcomes measure: Subject Compliance Rates with Weekly Pulmonary Artery (PA) Pressure Uploads, otherOutcomes measure: Number of Subjects with Heart Failure (HF) Prescription Medication Fills, otherOutcomes measure: Proportion of Subjects with Heart Failure (HF) Prescription Medication Fills, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Abbott Medical, city: Atlanta, state: Georgia, zip: 30313, country: United States, geoPoint lat: 33.749, lon: -84.38798, hasResults: False
protocolSection identificationModule nctId: NCT06306560, orgStudyIdInfo id: MA-SCLC-II-018, briefTitle: A Study of Adebrelimab Combined With Famitinib and Chemotherapy in the Treatment of ES-SCLC., statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-15, primaryCompletionDateStruct date: 2027-03-15, completionDateStruct date: 2027-04-15, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: Harbin Medical University, class: OTHER, descriptionModule briefSummary: This is a single arm, multi-center, phase II trial to evaluate the efficacy, and safety of adebrelimab combined with famitinib and chemotherapy for the treatment of first-line extensive stage small cell lung cancer., conditionsModule conditions: Extensive-stage Small-cell Lung Cancer, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 40, type: ESTIMATED, armsInterventionsModule interventions name: adebrelimab, interventions name: famitinib, interventions name: chemotherapy, outcomesModule primaryOutcomes measure: 6-month progression-free survival, secondaryOutcomes measure: 12-month progression-free survival, secondaryOutcomes measure: Objective Response Rate, secondaryOutcomes measure: Disease control rate, secondaryOutcomes measure: Overall Survival, secondaryOutcomes measure: AEs, secondaryOutcomes measure: QoL, secondaryOutcomes measure: Progression-Free-Survival, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06306547, orgStudyIdInfo id: IIM001, briefTitle: Clinical Study Cohort of Idiopathic Inflammatory Myositis, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2034-04-01, completionDateStruct date: 2034-04-01, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: RenJi Hospital, class: OTHER, descriptionModule briefSummary: Idiopathic inflammatory myositis (IIM), also known as myositis, are a heterogeneous group of diseases characterized by chronic inflammation of striated muscles and skin, with different clinical manifestations, treatment responses, and prognosis. This project will build a clinical follow-up cohort for idiopathic inflammatory myositis (IIM) centered on Renji Hospital, Shanghai Jiao Tong University School of Medicine, to promote the clinical and pathogenesis of this group of diseases., conditionsModule conditions: Idiopathic Inflammatory Myopathies, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: OTHER, enrollmentInfo count: 1000, type: ESTIMATED, armsInterventionsModule interventions name: no interventions were involved, outcomesModule primaryOutcomes measure: High Resolution Computed Tomography of Chest, primaryOutcomes measure: Cutaneous Disease Area and Severity Index, primaryOutcomes measure: Forced vital capacity, primaryOutcomes measure: Manual Muscle Testing, primaryOutcomes measure: Forced expiratory volume in one second, secondaryOutcomes measure: Serum creatine kinase, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 75 Years, stdAges: ADULT, stdAges: OLDER_ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06306534, orgStudyIdInfo id: AIS-001, secondaryIdInfos id: CIV-22-05-039592, type: OTHER_GRANT, domain: Blackrock Neurotech, briefTitle: Auditory Intranerve Stimulation Study, acronym: AIS, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-05-15, primaryCompletionDateStruct date: 2024-10-15, completionDateStruct date: 2024-11-15, studyFirstPostDateStruct date: 2024-03-12, lastUpdatePostDateStruct date: 2024-03-12, sponsorCollaboratorsModule leadSponsor name: Hannover Medical School, class: OTHER, descriptionModule briefSummary: This feasibility clinical investigation is designed to answer the question of whether auditory brainstem responses can be safely elicited by acute electrical stimulation within the human auditory nerve., conditionsModule conditions: Auditory; Nerve, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: Auditory Nerve Acute (ANA) Electrode Array, outcomesModule primaryOutcomes measure: Elicit a typical eABR Wave V with at least 0.2 µV in amplitude and a latency of the peak around 5 ms, secondaryOutcomes measure: Collection of adverse events, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hannover Medical School, status: RECRUITING, city: Hannover, zip: 30625, country: Germany, contacts name: Karl-Heinz Dyballa, role: CONTACT, email: dyballa.karl-heinz@mh-hannover.de, geoPoint lat: 52.37052, lon: 9.73322, hasResults: False