hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06272617, orgStudyIdInfo id: 2023-960, briefTitle: Acupuncture for Prevention and Treatment of Oral-related Complications Caused by Radiotherapy for Head and Neck Cancer, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-07-25, primaryCompletionDateStruct date: 2024-07-24, completionDateStruct date: 2025-07-24, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: West China Hospital, class: OTHER, collaborators name: West China Fourth Hospital, Sichuan University, descriptionModule briefSummary: A study on the efficacy and safety of acupuncture for the prevention and treatment of oral-related complications caused by radiotherapy for head and neck malignant tumors, conditionsModule conditions: Malignant Tumor of Head and/or Neck, conditions: Radiotherapy; Complications, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 138, type: ESTIMATED, armsInterventionsModule interventions name: verum acupuncture, interventions name: sham acupuncture, outcomesModule primaryOutcomes measure: Xerostomia questionnaire scores, secondaryOutcomes measure: Salivary flow rate, secondaryOutcomes measure: Taste function assessed by patients, secondaryOutcomes measure: Taste function assessed by electrogustometer test, secondaryOutcomes measure: Taste function assessed by taste strips test, secondaryOutcomes measure: Oral mucositis, secondaryOutcomes measure: Dysphagia, secondaryOutcomes measure: Quality of Life assessed by EORTC QLQ-C30, secondaryOutcomes measure: Quality of Life assessed by QLQ-H&N35, secondaryOutcomes measure: Adverse effects, secondaryOutcomes measure: Changes of oral flora, secondaryOutcomes measure: Tongue range of motion, secondaryOutcomes measure: Neck Fibrosis, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 80 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: West China Hospital, Sichuan University, status: RECRUITING, city: Chengdu, state: Sichuan, country: China, contacts name: Xingchen Peng, role: CONTACT, phone: 0086-18980606753, email: pxx2014@scu.edu.cn, geoPoint lat: 30.66667, lon: 104.06667, hasResults: False
protocolSection identificationModule nctId: NCT06272604, orgStudyIdInfo id: 2024-IRB-0015-P-01, briefTitle: Exercise Rehabilitation for Children With Asthma, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-01, primaryCompletionDateStruct date: 2027-04-01, completionDateStruct date: 2027-10-01, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: The Children's Hospital of Zhejiang University School of Medicine, class: OTHER, descriptionModule briefSummary: Asthma, a prevalent chronic condition among children and adolescents, substantially impairs their quality of life. In addressing this significant health concern, this study focuses on the potential of a customized exercise rehabilitation program tailored for this young demographic. By employing a randomized controlled trial design, the research aims to divide participants into two distinct groups: one undergoing a personalized exercise regimen and the other receiving standard medical care. The 12-week intervention for the exercise group includes a combination of aerobic activities, strength training, and targeted breathing exercises. The study's primary aim is to rigorously evaluate the impact of this specialized exercise protocol on critical health aspects such as lung function, physical endurance, frequency of asthma attacks, and overall quality of life. The anticipated findings from this research are expected to shed new light on effective asthma management strategies and offer invaluable guidance for clinical practices dedicated to improving health outcomes in young asthma patients., conditionsModule conditions: Asthma in Children, conditions: Rehabilitation, conditions: Exercise, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: SINGLE, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Personalized Exercise Rehabilitation, outcomesModule primaryOutcomes measure: Lung Function, primaryOutcomes measure: Daily Physical Activity Level, secondaryOutcomes measure: Asthma Control Status, secondaryOutcomes measure: Fractional Exhaled Nitric Oxide (FeNO), secondaryOutcomes measure: Body Composition, secondaryOutcomes measure: Sleep, secondaryOutcomes measure: Health Related Quality of Life, secondaryOutcomes measure: Anxiety and Depression, secondaryOutcomes measure: Inflammatory Mediators, eligibilityModule sex: ALL, minimumAge: 6 Years, maximumAge: 17 Years, stdAges: CHILD, hasResults: False
protocolSection identificationModule nctId: NCT06272578, orgStudyIdInfo id: 20021405, briefTitle: Screen CardRen - A Cross-sectional Observational Cohort Study, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2025-02-27, completionDateStruct date: 2025-06-30, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-23, sponsorCollaboratorsModule leadSponsor name: Charite University, Berlin, Germany, class: OTHER, collaborators name: AstraZeneca, descriptionModule briefSummary: In this single-centre, cross-sectional study, the investigators aim to assess the prevalence of asymptomatic echocardiographic structural and functional cardiac abnormalities in adult CKD patients with additional cardiovascular risk factors. Furthermore, with the use of Olink technology, analyses of the plasma proteome will be performed to identify potential protein pathways associated with early structural changes.The investigators hypothesize that protein expression will be altered in patients with prevalent echocardiographic abnormalities that indicate stage B heart failure., conditionsModule conditions: Heart Failure, conditions: Chronic Kidney Diseases, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 400, type: ESTIMATED, armsInterventionsModule interventions name: Echocardiography, outcomesModule primaryOutcomes measure: prevalence of significant asymptomatic cardiac structural abnormalities and cardiac dysfunction, primaryOutcomes measure: Proteomic analysis, secondaryOutcomes measure: Duration of echocardiographic examination, secondaryOutcomes measure: Time saved by portable echocardiography and automated image analysis, secondaryOutcomes measure: Image quality of cart-based vs. portable echo images, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06272565, orgStudyIdInfo id: 2023KYPJ292, briefTitle: Exploring the Interaction Between Metabolic Disorders and NLPR3 Inflammasome Activation in DR Inflammatory Damage, acronym: DR, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2026-12-30, completionDateStruct date: 2026-12-30, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Zhongshan Ophthalmic Center, Sun Yat-sen University, class: OTHER, descriptionModule briefSummary: Diabetic retinopathy (DR) is one of the most serious microvascular complications of diabetes. Early diagnosis and treatment of diabetes is the key to prevent visual impairment in DR patients. This study aims to use a non-targeted metabolomics detection technique combined with ultra-high performance liquid chromatography time-of-flight mass spectrometry to analyze the metabolomics profile in aqueous humor sample of DR patents, and further explore the mechanism of the relationship between differential metabolites and their metabolic pathways with NLRP3 activation in DR inflammatory damage. DR patients with macular edema will receive anti-vascular endothelial growth factor (anti-VEGF) treatment; these patients will be divided into two groups: responders group and non-responders group., conditionsModule conditions: Diabetic Retinopathy, conditions: Diabetic Macular Edema, conditions: Anti-vascular Endothelial Growth Factor, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 240, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Untargeted metabolomics for metabolic profile using UHPLC/MS, secondaryOutcomes measure: Best-corrected visual acuity, secondaryOutcomes measure: Central subfield thickness, eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Zhongshan Ophthalmic Center of Sun Yat-sen University, city: Guangzhou, state: Guangdong, zip: 510623, country: China, contacts name: Zhongshan Ophthalmic Center of Sun Yat-sen University, role: CONTACT, phone: 86+13560323773, email: chh5413@126.com, geoPoint lat: 23.11667, lon: 113.25, hasResults: False
protocolSection identificationModule nctId: NCT06272526, orgStudyIdInfo id: SOCIALANX_1, briefTitle: Internet-Based Self-Help Intervention for Social Anxiety Symptoms, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2024-10-01, completionDateStruct date: 2024-12-31, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Anadolu University, class: OTHER, descriptionModule briefSummary: This study is a randomized-controlled trial in which the assumed superiority of the module internet-based cognitive behavioral therapy intervention for social anxiety disorder is evaluated compared to a waitlist control group. Participants will be assigned to one of two groups, treatment which have web-based intervention (guided), and waitlist.The intervention program will be offered to treatment group participants (guided) through the website https://kendikendineyardim.org, the unique online self-help platform in Turkey. Participants in the web-based treatment group will receive feedback message within 24 hours after each completed module from the guides., conditionsModule conditions: Mental Health Issue, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: INVESTIGATOR, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule interventions name: Internet Based Intervention - GUIDED, outcomesModule primaryOutcomes measure: Liebowitz Social Anxiety Scale (LSAS) Turkish Form, secondaryOutcomes measure: Social Appearance Anxiety Scale (SAAS) Turkish Form, secondaryOutcomes measure: Patient Health Questionnaire-9 (PHQ-9) Turkish Form, secondaryOutcomes measure: Generalized Anxiety Disorder-7 (GAD-7) Turkish Form, otherOutcomes measure: Sociodemographic Information Form, otherOutcomes measure: System Usability Scale (SUS-10) Turkish Form, otherOutcomes measure: Attitudes Toward Internet-Based Interventions Scale (ETAM) Turkish Form, otherOutcomes measure: Adherence to Intervention, otherOutcomes measure: Guide Evaluation, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06272513, orgStudyIdInfo id: ProAct-HNC-02, briefTitle: Influencing Factors for Physical Activity in People With Head and Neck Cancer, acronym: ProAct-HNC, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03, primaryCompletionDateStruct date: 2025-03-31, completionDateStruct date: 2025-06-30, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-26, sponsorCollaboratorsModule leadSponsor name: Kantonsspital Winterthur KSW, class: OTHER, collaborators name: Eastern Switzerland University of Applied Sciences, collaborators name: University of Applied Sciences of Western Switzerland, collaborators name: UMC Utrecht, collaborators name: University of Lausanne, collaborators name: Zurich University of Applied Sciences, descriptionModule briefSummary: The goal of this qualitative study is to explore influencing factors for physical activity participation in people affected by an advanced head and neck cancer from the perspective of people affected and their significant others.Individual interviews will be conducted with people affected by head and neck cancer and focus group interviews will be held with significant others of people being affected to answer the following research questions:* What capabilities and opportunities for physical activity participation do people with advanced head and neck cancer experience?* What motivates people with advanced head and neck cancer to be physically active?* How do significant others view capabilities, opportunities, and motivation for physical activity participation in people with head and neck cancer?The interviews will be transcribed verbatim and analysed with a structuring content analysis approach., conditionsModule conditions: Advanced Head and Neck Squamous Cell Carcinoma, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: PROSPECTIVE, enrollmentInfo count: 20, type: ESTIMATED, outcomesModule primaryOutcomes measure: interview transcripts, secondaryOutcomes measure: personal information of participants, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, documentSection largeDocumentModule largeDocs typeAbbrev: Prot, hasProtocol: True, hasSap: False, hasIcf: False, label: Study Protocol, date: 2024-02-09, uploadDate: 2024-02-15T04:21, filename: Prot_000.pdf, size: 1702659, hasResults: False
protocolSection identificationModule nctId: NCT06272487, orgStudyIdInfo id: ALN-AGT01-007, briefTitle: Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3), acronym: KARDIA-3, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-29, primaryCompletionDateStruct date: 2025-03-20, completionDateStruct date: 2025-12-19, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-04-18, sponsorCollaboratorsModule leadSponsor name: Alnylam Pharmaceuticals, class: INDUSTRY, descriptionModule briefSummary: The purpose of this study is to evaluate the effect of zilebesiran as add-on therapy in patients with high cardiovascular risk and hypertension not adequately controlled by standard of care antihypertensive medications., conditionsModule conditions: High Cardiovascular Risk, conditions: Hypertension, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 390, type: ESTIMATED, armsInterventionsModule interventions name: Zilebesiran, interventions name: Placebo, outcomesModule primaryOutcomes measure: Change from Baseline at Month 3 in Mean Seated Office Systolic Blood Pressure (SBP), secondaryOutcomes measure: Change from Baseline at Month 3 in 24-Hour Mean SBP Assessed by Ambulatory Blood Pressure Monitoring (ABPM), secondaryOutcomes measure: Change from Baseline at Month 6 in Mean Seated Office SBP, secondaryOutcomes measure: Change from Baseline at Month 6 in 24-Hour Mean SBP Assessed by ABPM, secondaryOutcomes measure: Proportion of Patients with Mean Seated Office SBP <140 mmHg and/or Reduction ≥10 mmHg without Intensification of Antihypertensive Regimen at Month 6, secondaryOutcomes measure: Proportion of Patients with 24-hour Mean SBP assessed by ABPM <130 mmHg and/or Reduction ≥10 mmHg without Intensification of Antihypertensive Regimen at Month 6, secondaryOutcomes measure: Change from Baseline at Month 3 and Month 6 in Daytime and Nighttime Mean SBP and Diastolic Blood Pressure (DBP) assessed by ABPM, secondaryOutcomes measure: Change from Baseline at Month 3 and Month 6 in Mean Seated Office DBP, secondaryOutcomes measure: Change from Baseline at Month 3 and Month 6 in 24-hour Mean DBP Assessed by ABPM, secondaryOutcomes measure: Change from Baseline Over Time in Serum Angiotensinogen (AGT), eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Clinical Trial Site, status: RECRUITING, city: Flint, state: Michigan, zip: 48504, country: United States, geoPoint lat: 43.01253, lon: -83.68746, hasResults: False
protocolSection identificationModule nctId: NCT06272474, orgStudyIdInfo id: 0266-07/2021 - 18/07/2021, briefTitle: Virtual Reproduction of Mandibular Movement for Assessing Occlusal Interferences and Adjustments, statusModule overallStatus: COMPLETED, startDateStruct date: 2022-09-11, primaryCompletionDateStruct date: 2023-12-09, completionDateStruct date: 2023-12-09, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-02-22, sponsorCollaboratorsModule leadSponsor name: Hams Hamed Abdelrahman, class: OTHER, descriptionModule briefSummary: Computer-aided designs have considered dynamic occlusion with virtual articulator systems. However, the process involved is currently lengthy. The simplified transfer of casts from a mechanical to a virtual articulator has required bulky and expensive instruments. Recently, new methods based on mandibular motion tracking using optical devices have been introduced for integrating individual functional movement into occlusal morphology.The aim of this study: This study will clinically assess the reliability of the virtual reproduction of mandibular movement for detecting occlusal interferences and adjustments of designed and milled CAD-CAM zirconia crowns using a digital occlusal analyzer.Materials and methods: Intraoral optical impression will be made for thirteen selected patients with endodontically treated maxillary first premolars after abutment preparation followed by buccal and lateral interocclusal records taking. Two zirconia crowns will be fabricated for each patient following regular digital workflow with twenty six zirconia crowns, which will be allocated according to the virtual method of adjustment of occlusal interferences into two groups (Group I: Virtual occlusal interferences adjustment of CAD-CAM zirconia crowns using buccal interocclusal record (n=13) and Group II: Virtual occlusal interferences adjustment of CAD-CAM zirconia crowns using buccal and lateral interocclusal records (n=13)). Then milling and sintering of all crowns will be performed following the manufacturer's instructions. The occlusion of all crowns will be analyzed using an electronic pressure analyzer. All data will be statistically analyzed and discussed in light of the results obtained., conditionsModule conditions: Dental Occlusion, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: SINGLE_GROUP, interventionModelDescription: Single group is receiving the two interventional arms, primaryPurpose: DIAGNOSTIC, maskingInfo masking: NONE, enrollmentInfo count: 26, type: ACTUAL, armsInterventionsModule interventions name: CAD-CAM zirconia crowns using buccal interocclusal record., interventions name: CAD-CAM zirconia crowns using lateral interocclusal records., outcomesModule primaryOutcomes measure: Static occlusal interference, primaryOutcomes measure: Dynamic occlusal interference, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 35 Years, stdAges: ADULT, contactsLocationsModule locations facility: Alexandria Faculty of Dentistry, city: Alexandria, country: Egypt, geoPoint lat: 31.21564, lon: 29.95527, hasResults: False
protocolSection identificationModule nctId: NCT06272461, orgStudyIdInfo id: UTEM ELKI, briefTitle: Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-10-01, primaryCompletionDateStruct date: 2024-05-30, completionDateStruct date: 2024-06-30, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-04-16, sponsorCollaboratorsModule leadSponsor name: University Tunis El Manar, class: OTHER, descriptionModule briefSummary: Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta).For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours.For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours.Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively., conditionsModule conditions: Colorectal (Colon or Rectal) Cancer, conditions: Inflammation, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Intravenous Lidocaine vs intravenous ketamine, primaryPurpose: PREVENTION, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, enrollmentInfo count: 50, type: ESTIMATED, armsInterventionsModule interventions name: Lidocaine IV, interventions name: Ketamine Injectable Solution, outcomesModule primaryOutcomes measure: The variation of Interleukin-6 levels, secondaryOutcomes measure: Pain assessed by Numerical Rating Scale (NRS), secondaryOutcomes measure: Post-operative nausea and vomiting, secondaryOutcomes measure: Bowel function., secondaryOutcomes measure: Hospital length of stay., secondaryOutcomes measure: Post-operative complications., eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 90 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Tunisia, status: RECRUITING, city: Nabeul, zip: 8000, country: Tunisia, contacts name: BEN ALI MECHAAL, role: CONTACT, phone: 53890987, phoneExt: 00216, email: mechaal_benali@yahoo.fr, geoPoint lat: 36.45606, lon: 10.73763, hasResults: False