protocolSection identificationModule nctId: NCT06272643, orgStudyIdInfo id: EPIC36-EMPERATRIZ, briefTitle: Comparison Between Optical Coherence Tomography and Intravascular Ultrasound for Intermediate Left Main Coronary Artery Lesions, acronym: EMPERATRIZ, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-04, primaryCompletionDateStruct date: 2025-01-20, completionDateStruct date: 2026-01-20, studyFirstPostDateStruct date: 2024-02-22, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Fundación EPIC, class: OTHER, descriptionModule briefSummary: Significant coronary disease of the left main coronary artery (LMCA) is found in 4%-5% of all coronary angiography procedures. Classically, it has been determined that a significant angiographic stenosis should reach at least 50% of the vessel diameter by visual estimation, which corresponds to 75% of the vessel area. However, angiography has a number of limitations inherent to the technique and location of stenosis, and other techniques are therefore available for evaluation. Intracoronary ultrasound (IVUS) deserves, together with the pressure guidewire, special consideration in determining the severity assessment (anatomical and functional) of lesions in this location. Using IVUS the most commonly used cut-off value is 6 mm2. in ambiguous lesions of the LMCA, a MLA \>6 mm2 would indicate no revascularisation, a MLA \<4.5-5 mm2 would indicate revascularisation, and MLA values between 4.5-5 and 6 mm2 would make it advisable to use FRF/iFR to decide. Optical coherence tomography (OCT) is another intracoronary imaging modality, with greater resolution and significant differences from IVUS. no MLA cut-off point with OCT has been demonstrated for the management of LMCA lesions. Due to the differences in imaging with both techniques, the thresholds established as cut-off points in IVUS cannot be extrapolated to OCT. The objective is to compare the minimal luminal area by IVUS and OCT of angiographically intermediate LCMA lesions and to assess the prognostic value of TCFA assessed by OCT., conditionsModule conditions: Coronary Disease, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_ONLY, timePerspective: PROSPECTIVE, enrollmentInfo count: 129, type: ESTIMATED, armsInterventionsModule interventions name: IVUS (Intravascular Ultrasound) and OCT (Optical Coherence Tomography), outcomesModule primaryOutcomes measure: To assess the agreement between minimum luminal area measured by IVUS and OCT in intermediate LCMA lesions, secondaryOutcomes measure: Cardiac Death, secondaryOutcomes measure: Cardiovascular Death, secondaryOutcomes measure: Acute myocardial infarction of treated/functionally assessed lesion, secondaryOutcomes measure: Acute myocardial infarction of any lesion, secondaryOutcomes measure: Need for revascularisation of lesion treated/functionally assessed, secondaryOutcomes measure: Need for revascularisation of any lesion, secondaryOutcomes measure: Secondary efficacy endpoint: Clear Image Length, secondaryOutcomes measure: Extend of detectable EEL in LM, secondaryOutcomes measure: Correlation between contrast volume used and results, as well as the average contrast volume used in the study., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Hospital Universitario Juan Ramon Jimenez, status: RECRUITING, city: Huelva, zip: 21005, country: Spain, geoPoint lat: 37.26638, lon: -6.94004, locations facility: Hospital Universitario de Leon, status: RECRUITING, city: León, zip: 24071, country: Spain, geoPoint lat: 42.60003, lon: -5.57032, hasResults: False