protocolSection identificationModule nctId: NCT06328127, orgStudyIdInfo id: 23-691, briefTitle: Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors, acronym: PATH-4, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06-01, primaryCompletionDateStruct date: 2026-06-30, completionDateStruct date: 2029-04-30, studyFirstPostDateStruct date: 2024-03-25, lastUpdatePostDateStruct date: 2024-03-25, sponsorCollaboratorsModule leadSponsor name: Brigham and Women's Hospital, class: OTHER, collaborators name: Dana-Farber Cancer Institute, collaborators name: Duke University, collaborators name: H. Lee Moffitt Cancer Center and Research Institute, descriptionModule briefSummary: This randomized clinical trial is evaluating the impact of a positive psychology intervention (PATH) on anxiety symptoms, depression symptoms, and quality of life in survivors of hematopoietic stem cell transplant (HSCT) compared to usual care., conditionsModule conditions: Hematopoietic Stem Cell Transplant, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: NONE, enrollmentInfo count: 400, type: ESTIMATED, armsInterventionsModule interventions name: PATH, outcomesModule primaryOutcomes measure: Anxiety Symptoms based on the Hospital Anxiety and Depression Scale-Anxiety Subscale, secondaryOutcomes measure: Anxiety Symptoms based on the Hospital Anxiety and Depression Scale-Anxiety Subscale, secondaryOutcomes measure: Depression Symptoms based on the Hospital Anxiety and Depression Scale-Depression Subscale, secondaryOutcomes measure: Gratitude based on the Gratitude Questionnaire, secondaryOutcomes measure: Positive Affect based on the Positive and Negative Affect Schedule Positive Affect Subscale, secondaryOutcomes measure: Physical function based on the Patient-Reported Outcomes Measurement Information System-Physical Function-20, secondaryOutcomes measure: Patient-Reported Quality of Life based on the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT), otherOutcomes measure: Flourishing based on the Flourishing Scale, otherOutcomes measure: Optimism based on the Life Orientation Test-Revised (LOT-R), otherOutcomes measure: Coping based on the Brief-COPE questionnaire, otherOutcomes measure: Post-traumatic stress based on the Post-traumatic Stress Checklist-Civilian Version, otherOutcomes measure: Steps per day based on the ActiGraph accelerometer, otherOutcomes measure: Sedentary leisure time based on the ActiGraph accelerometer, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Moffitt Cancer Center, city: Tampa, state: Florida, zip: 33612, country: United States, contacts name: Heather Jim, PhD, role: CONTACT, email: heather.jim@moffitt.org, geoPoint lat: 27.94752, lon: -82.45843, locations facility: Dana Farber Cancer Institute, city: Boston, state: Massachusetts, zip: 02215, country: United States, geoPoint lat: 42.35843, lon: -71.05977, locations facility: Duke Cancer Institute, city: Durham, state: North Carolina, zip: 27710, country: United States, contacts name: Thomas LeBlanc, MD, role: CONTACT, email: thomas.leblanc@duke.edu, geoPoint lat: 35.99403, lon: -78.89862, hasResults: False