protocolSection identificationModule nctId: NCT06267001, orgStudyIdInfo id: GO45006, secondaryIdInfos id: 2023-506696-10-00, type: REGISTRY, domain: EU CT, briefTitle: A Study of Tiragolumab Plus Atezolizumab Compared With Placebo Plus Atezolizumab in Participants With Completely Resected Non-small Cell Lung Cancer Who Have Received Adjuvant Platinum-based Chemotherapy, acronym: SKYSCRAPER-15, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-03-21, primaryCompletionDateStruct date: 2034-03-31, completionDateStruct date: 2039-06-30, studyFirstPostDateStruct date: 2024-02-20, lastUpdatePostDateStruct date: 2024-04-26, sponsorCollaboratorsModule leadSponsor name: Hoffmann-La Roche, class: INDUSTRY, descriptionModule briefSummary: The purpose of this study is to evaluate the efficacy and safety of tiragolumab plus atezolizumab compared with placebo plus atezolizumab administered to participants with non-small cell lung cancer (NSCLC) following resection and adjuvant chemotherapy., conditionsModule conditions: Non-small Cell Lung Cancer (NSCLC), designModule studyType: INTERVENTIONAL, phases: PHASE3, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: QUADRUPLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 1150, type: ESTIMATED, armsInterventionsModule interventions name: Atezolizumab, interventions name: Tiragolumab, interventions name: Placebo, outcomesModule primaryOutcomes measure: Disease-free Survival (DFS), secondaryOutcomes measure: Percentage of Participants With Adverse Events (AEs), secondaryOutcomes measure: Overall Survival (OS), secondaryOutcomes measure: DFS Rate, secondaryOutcomes measure: Percentage of Participants Who Maintained or Meaningfully Improved from Baseline in Patient-reported Role, Emotional, and Physical Functioning and Global Health Status (GHS)/Quality of Life (QoL), secondaryOutcomes measure: Serum Concentration of Tiragolumab, secondaryOutcomes measure: Serum Concentration of Atezolizumab, secondaryOutcomes measure: Percentage of Participants With Anti-Drug Antibodies (ADAs) to Tiragolumab, secondaryOutcomes measure: Percentage of Participants With ADAs to Atezolizumab, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The Oncology Institute of Hope and Innovation; Cerritos, status: RECRUITING, city: Cerritos, state: California, zip: 90703, country: United States, geoPoint lat: 33.85835, lon: -118.06479, locations facility: University of California, San Francisco; Medical Center, status: RECRUITING, city: San Francisco, state: California, zip: 94158, country: United States, geoPoint lat: 37.77493, lon: -122.41942, locations facility: Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, status: RECRUITING, city: Marietta, state: Georgia, zip: 30060, country: United States, geoPoint lat: 33.9526, lon: -84.54993, locations facility: Springfield Clinic, status: RECRUITING, city: Springfield, state: Illinois, zip: 62702, country: United States, geoPoint lat: 39.80172, lon: -89.64371, locations facility: UNM Lovelace, status: RECRUITING, city: Albuquerque, state: New Mexico, zip: 87102, country: United States, geoPoint lat: 35.08449, lon: -106.65114, locations facility: University of New Mexico Cancer Center, status: RECRUITING, city: Albuquerque, state: New Mexico, zip: 87106, country: United States, geoPoint lat: 35.08449, lon: -106.65114, locations facility: Asante Rogue Regional Medical Center, status: RECRUITING, city: Medford, state: Oregon, zip: 97504-8332, country: United States, geoPoint lat: 42.32652, lon: -122.87559, locations facility: Hospital Britanico; Oncologia, status: RECRUITING, city: Buenos Aires, zip: C1280AEB, country: Argentina, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Centro Oncologico Korben; Oncology, status: RECRUITING, city: Ciudad Autonoma Buenos Aires, zip: C1426AGE, country: Argentina, geoPoint lat: -34.61315, lon: -58.37723, locations facility: CINME S.A. ? Centro de Investigaciones Metabolicas - Rx Trials LLC, status: RECRUITING, city: Ciudad Autonoma de Buenos Aires, zip: C1027AAP, country: Argentina, geoPoint lat: -34.61315, lon: -58.37723, locations facility: Sunshine Coast University Hospital; The Adem Crosby Centre, status: RECRUITING, city: Birtinya, state: Queensland, zip: 4575, country: Australia, geoPoint lat: -26.74322, lon: 153.11913, locations facility: Greenslopes Private Hospital; Gallipoli Research Centre, status: RECRUITING, city: Greenslopes, state: Queensland, zip: 4120, country: Australia, geoPoint lat: -27.50815, lon: 153.04951, locations facility: Cancer Research SA, status: RECRUITING, city: Adelaide, state: South Australia, zip: 5000, country: Australia, geoPoint lat: -34.92866, lon: 138.59863, locations facility: Monash Health, status: RECRUITING, city: Clayton, state: Victoria, zip: 3168, country: Australia, geoPoint lat: -37.91667, lon: 145.11667, locations facility: Hospital de Cancer de Barretos, status: RECRUITING, city: Barretos, state: SP, zip: 14784-400, country: Brazil, geoPoint lat: -20.55722, lon: -48.56778, locations facility: Hospital A. C. Camargo; Oncologia, status: RECRUITING, city: Sao Paulo, state: SP, zip: 01509-010, country: Brazil, geoPoint lat: -23.5475, lon: -46.63611, locations facility: Changzhou First People's Hospital; Oncology, status: RECRUITING, city: Changzhou, zip: 213003, country: China, geoPoint lat: 31.77359, lon: 119.95401, locations facility: The First Affiliated Hospital of Sun Yat-sen University, status: RECRUITING, city: Guangzhou City, zip: 510080, country: China, locations facility: Guangdong General Hospital, status: RECRUITING, city: Guangzhou, zip: 510080, country: China, geoPoint lat: 23.11667, lon: 113.25, locations facility: Shandong Cancer Hospital, status: RECRUITING, city: Jinan, zip: 250117, country: China, geoPoint lat: 36.66833, lon: 116.99722, locations facility: Yunnan Cancer Hospital, status: RECRUITING, city: Kunming, zip: 650118, country: China, geoPoint lat: 25.03889, lon: 102.71833, locations facility: The First Affiliated Hospital of Nanchang University, status: RECRUITING, city: Nanchang City, zip: 330008, country: China, locations facility: Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, status: RECRUITING, city: Nanjing City, zip: 210008, country: China, locations facility: Ningbo No.2 Hospital, status: RECRUITING, city: Ningbo, country: China, geoPoint lat: 29.87819, lon: 121.54945, locations facility: Zhongshan Hospital Fudan University, status: RECRUITING, city: Shanghai, zip: 200032, country: China, geoPoint lat: 31.22222, lon: 121.45806, locations facility: Shanghai Pulmonary Hospital, status: RECRUITING, city: Shanghai, zip: 200433, country: China, geoPoint lat: 31.22222, lon: 121.45806, locations facility: Liaoning Provincial Cancer Hospital, status: RECRUITING, city: Shengyang, zip: 110042, country: China, locations facility: Tianjin Cancer Hospital, status: RECRUITING, city: Tianjin, zip: 300060, country: China, geoPoint lat: 39.14222, lon: 117.17667, locations facility: Tongji Hospital Tongji Medical College Huazhong University of Science and Technology, status: RECRUITING, city: Wuhan City, zip: 430030, country: China, locations facility: The Affiliated Hospital of Xuzhou Medical University, status: RECRUITING, city: Xuzhou, country: China, geoPoint lat: 34.18045, lon: 117.15707, locations facility: The First Affiliated Hospital of Zhengzhou University, status: RECRUITING, city: Zhengzhou, zip: 450052, country: China, geoPoint lat: 34.75778, lon: 113.64861, locations facility: Kindai University Hospital, status: RECRUITING, city: Osaka, zip: 589-8511, country: Japan, geoPoint lat: 34.69374, lon: 135.50218, locations facility: Pusan National University Hospital, status: RECRUITING, city: Busan, zip: 602-739, country: Korea, Republic of, geoPoint lat: 35.10278, lon: 129.04028, locations facility: Chungbuk National University Hospital, status: RECRUITING, city: Cheongju si, zip: 28644, country: Korea, Republic of, geoPoint lat: 36.63722, lon: 127.48972, locations facility: Kyungpook National University Chilgok Hospital, status: RECRUITING, city: Daegu, zip: 41404, country: Korea, Republic of, geoPoint lat: 35.87028, lon: 128.59111, locations facility: St. Vincent's Hospital, status: RECRUITING, city: Gyeonggi-do, zip: 16247, country: Korea, Republic of, geoPoint lat: 37.58944, lon: 126.76917, locations facility: Pusan National University Yangsan Hospital, status: RECRUITING, city: Gyeongsangnam-do, zip: 50612, country: Korea, Republic of, locations facility: Chonnam National University Hwasun Hospital, status: RECRUITING, city: Jeollanam-do, zip: 58128, country: Korea, Republic of, locations facility: Seoul National University Bundang Hospital, status: RECRUITING, city: Seongnam-si, zip: 463-707, country: Korea, Republic of, geoPoint lat: 37.43861, lon: 127.13778, locations facility: Seoul National University Hospital, status: RECRUITING, city: Seoul, zip: 03080, country: Korea, Republic of, geoPoint lat: 37.566, lon: 126.9784, locations facility: Severance Hospital, Yonsei University Health System, status: RECRUITING, city: Seoul, zip: 03722, country: Korea, Republic of, geoPoint lat: 37.566, lon: 126.9784, locations facility: Asan Medical Center, status: RECRUITING, city: Seoul, zip: 05505, country: Korea, Republic of, geoPoint lat: 37.566, lon: 126.9784, locations facility: Samsung Medical Center, status: RECRUITING, city: Seoul, zip: 06351, country: Korea, Republic of, geoPoint lat: 37.566, lon: 126.9784, locations facility: Korea University Guro Hospital, status: RECRUITING, city: Seoul, zip: 08308, country: Korea, Republic of, geoPoint lat: 37.566, lon: 126.9784, locations facility: Ulsan University Hosiptal, status: RECRUITING, city: Ulsan, zip: 44033, country: Korea, Republic of, geoPoint lat: 35.53722, lon: 129.31667, locations facility: Kaohsiung Medical Uni Chung-Ho Memorial Hospital; Dept of Internal Medicine, status: RECRUITING, city: Kaohsiung, zip: 807, country: Taiwan, geoPoint lat: 22.61626, lon: 120.31333, locations facility: Taichung Veterans General Hospital; Dept of Internal Medicine, status: RECRUITING, city: Taichung, zip: 407, country: Taiwan, geoPoint lat: 24.1469, lon: 120.6839, locations facility: Taipei Veterans General Hospital; Chest Dept, Section of Thoracic Oncology, status: RECRUITING, city: Taipei, zip: 112, country: Taiwan, geoPoint lat: 25.04776, lon: 121.53185, locations facility: Tri-Service General Hospital; Dept. of Internal Medicine, status: RECRUITING, city: Taipei, zip: 114, country: Taiwan, geoPoint lat: 25.04776, lon: 121.53185, hasResults: False