protocolSection identificationModule nctId: NCT06389266, orgStudyIdInfo id: 221550, briefTitle: Network-Targeted Neuromodulation for Nicotine Dependence in Schizophrenia, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-06-15, primaryCompletionDateStruct date: 2029-01-10, completionDateStruct date: 2029-01-10, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: Vanderbilt University Medical Center, class: OTHER, descriptionModule briefSummary: The goal of this clinical trial is to compare two active types of transcranial magnetic stimulation in two nicotine-using populations: nicotine-using people with psychosis and nicotine-using people without a diagnosis of a psychotic disorder. The main questions it aims to answer are:1. Can rTMS change functional connectivity in brain circuits associated with nicotine use?2. Are those rTMS-induced changes in functional connectivity related to craving?Participants will complete tasks assessing their cognitive performance and craving before and after each week of TMS. Researchers will compare the effect of each TMS intervention on participants with and without psychosis to see if one type of TMS has an effect on nicotine craving., conditionsModule conditions: Schizophrenia, conditions: Nicotine Dependence, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: CROSSOVER, interventionModelDescription: All participants receive five days of DMN-targeted cTBS and five days of L DLPFC-targeted iTBS. The order in which participants receive the two types of TMS is randomized., primaryPurpose: BASIC_SCIENCE, maskingInfo masking: NONE, maskingDescription: The study is not sham-controlled, as both arms are active TMS treatments. The type of TMS is not masked from the participant or the investigator. Statistician will be blinded to intervention., enrollmentInfo count: 100, type: ESTIMATED, armsInterventionsModule interventions name: Repetitive Transcranial Magnetic Stimulation (rTMS), outcomesModule primaryOutcomes measure: Resting-state functional connectivity, primaryOutcomes measure: Cue-induced craving, primaryOutcomes measure: Tiffany Brief Questionnaire of Smoking Urges (QSU), primaryOutcomes measure: Self-reported craving, secondaryOutcomes measure: Wisconsin Smoking Withdrawal Scale (WSWS), secondaryOutcomes measure: Fagerstrom Test for Nicotine Dependence (FTND), secondaryOutcomes measure: Self-reported nicotine use, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Vanderbilt University Medical Center, status: RECRUITING, city: Nashville, state: Tennessee, zip: 37232, country: United States, contacts name: Heather B Ward, MD, role: CONTACT, phone: 615-327-7000, email: heather.b.ward@vumc.org, contacts name: Sophia H Blyth, BA, role: CONTACT, phone: 6154345891, email: sophia.h.blyth@vumc.org, contacts name: Stephan Heckers, MD, MSc, role: SUB_INVESTIGATOR, contacts name: Hilary A Tindle, MD, MPH, role: SUB_INVESTIGATOR, geoPoint lat: 36.16589, lon: -86.78444, hasResults: False