protocolSection identificationModule nctId: NCT06311383, orgStudyIdInfo id: CLEE011ADE03, briefTitle: A Non-interventional Study for Women With HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer to Evaluate the Real-world Effectiveness of Treatment Algorithms Beginning With Ribociclib + AI/FUL, or With Endocrine Therapy or Chemotherapy as First Line Treatment, acronym: RIBANNA, statusModule overallStatus: ACTIVE_NOT_RECRUITING, startDateStruct date: 2017-10-09, primaryCompletionDateStruct date: 2025-02-16, completionDateStruct date: 2025-02-16, studyFirstPostDateStruct date: 2024-03-15, lastUpdatePostDateStruct date: 2024-04-05, sponsorCollaboratorsModule leadSponsor name: Novartis Pharmaceuticals, class: INDUSTRY, descriptionModule briefSummary: This is a non-interventional observational study conducted in Germany to evaluate the real-world effectiveness, tolerability, safety, and quality of life in patients with locally advanced/metastatic HR+/HER2- breast cancer treated with one of the following 1st line treatments: Ribociclib + AI/FUL, or endocrine monotherapy, or chemotherapy, conditionsModule conditions: Breast Cancer, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 2610, type: ACTUAL, armsInterventionsModule interventions name: First-line Ribociclib + endocrine therapy, interventions name: First-line endocrine therapy, interventions name: First-line chemtherapy, outcomesModule primaryOutcomes measure: Progression-free survival (PFS), secondaryOutcomes measure: Cox proportional hazard regression for progression free survival in 1st line therapy, secondaryOutcomes measure: Propensity Score matching for progression free survival in 1st line therapy, secondaryOutcomes measure: Sequential progression-free survival (PFS_S), secondaryOutcomes measure: Conditional progression-free survival, secondaryOutcomes measure: Time to treatment failure (TTF), secondaryOutcomes measure: Time to first chemotherapy, secondaryOutcomes measure: Time to next treatment / therapy (TTNT) after 1st line treatment, secondaryOutcomes measure: Overall survival (OS), secondaryOutcomes measure: Dose reduction, secondaryOutcomes measure: Dose interruption, secondaryOutcomes measure: Discontinuations, secondaryOutcomes measure: Adherence - MMAS-8 questionnaire, secondaryOutcomes measure: Number of participants with mutations, secondaryOutcomes measure: Quality of life for specific cohorts and treatment lines - EORTC QLQ-C30, secondaryOutcomes measure: Quality of life for specific cohorts and treatment lines - EORTC QLQ-B23, secondaryOutcomes measure: Quality of life for specific cohorts and treatment lines - HADS-D, eligibilityModule sex: FEMALE, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Novartis Investigative Site, city: Freudenstadt, state: Baden Wuerttemberg, zip: 72250, country: Germany, geoPoint lat: 48.46695, lon: 8.41371, locations facility: Novartis Investigative Site, city: Karlsruhe, state: Baden Wuerttemberg, zip: 76199, country: Germany, geoPoint lat: 49.00937, lon: 8.40444, locations facility: Novartis Investigative Site, city: Mannheim, state: Baden Wuerttemberg, zip: 68165, country: Germany, geoPoint lat: 49.4891, lon: 8.46694, locations facility: Novartis Investigative Site, city: Nuertingen, state: Baden Wuerttemberg, zip: 72622, country: Germany, locations facility: Novartis Investigative Site, city: Reutlingen, state: Baden Wuerttemberg, zip: 72764, country: Germany, geoPoint lat: 48.49144, lon: 9.20427, locations facility: Novartis Investigative Site, city: Winnenden, state: Baden Wuerttemberg, zip: 71364, country: Germany, geoPoint lat: 48.87563, lon: 9.39819, locations facility: Novartis Investigative Site, city: Ostfildern, state: Baden Württemberg, zip: 73760, country: Germany, geoPoint lat: 48.72704, lon: 9.24954, locations facility: Novartis Investigative Site, city: Baden-Baden, state: Baden-Wuerttemberg, zip: 76532, country: Germany, geoPoint lat: 48.7606, lon: 8.23975, locations facility: Novartis Investigative Site, city: Mutlangen, state: Baden-Wuerttemberg, zip: 73557, country: Germany, geoPoint lat: 48.82588, lon: 9.79714, locations facility: Novartis Investigative Site, city: Rottweil, state: Baden-Wuerttemberg, zip: 78628, country: Germany, geoPoint lat: 48.16783, lon: 8.62719, locations facility: Novartis Investigative Site, city: Schwaebisch, state: Baden-Wuerttemberg, zip: 74523, country: Germany, locations facility: Novartis Investigative Site, city: Sigmaringen, state: Baden-Wuerttemberg, zip: 72488, country: Germany, geoPoint lat: 48.08829, lon: 9.23033, locations facility: Novartis Investigative Site, city: Augsburg, state: Bavaria, zip: 86152, country: Germany, geoPoint lat: 48.37154, lon: 10.89851, locations facility: Novartis Investigative Site, city: Bamberg, state: Bavaria, zip: 96052, country: Germany, geoPoint lat: 49.89873, lon: 10.90067, locations facility: Novartis Investigative Site, city: Muenchen, state: Bavaria, zip: 80639, country: Germany, geoPoint lat: 51.60698, lon: 13.31243, locations facility: Novartis Investigative Site, city: Altoetting, state: Bayern, zip: 84503, country: Germany, locations facility: Novartis Investigative Site, city: Amberg, state: Bayern, zip: 92224, country: Germany, geoPoint lat: 49.44287, lon: 11.86267, locations facility: Novartis Investigative Site, city: Ansbach, state: Bayern, zip: 91522, country: Germany, geoPoint lat: 49.30481, lon: 10.5931, locations facility: Novartis Investigative Site, city: Aschaffenburg, state: Bayern, zip: 63739, country: Germany, geoPoint lat: 49.97704, lon: 9.15214, locations facility: Novartis Investigative Site, city: Bayreuth, state: Bayern, zip: 95445, country: Germany, geoPoint lat: 49.94782, lon: 11.57893, locations facility: Novartis Investigative Site, city: Ebersberg, state: Bayern, zip: 85560, country: Germany, geoPoint lat: 48.0771, lon: 11.97063, locations facility: Novartis Investigative Site, city: Landshut, state: Bayern, zip: 84036, country: Germany, geoPoint lat: 48.52961, lon: 12.16179, locations facility: Novartis Investigative Site, city: Muenchen, state: Bayern, zip: 81241, country: Germany, geoPoint lat: 51.60698, lon: 13.31243, locations facility: Novartis Investigative Site, city: Muenchen, state: Bayern, zip: 81925, country: Germany, geoPoint lat: 51.60698, lon: 13.31243, locations facility: Novartis Investigative Site, city: Nuernberg, state: Bayern, zip: 90409, country: Germany, geoPoint lat: 49.45421, lon: 11.07752, locations facility: Novartis Investigative Site, city: Regensburg, state: Bayern, zip: 93053, country: Germany, geoPoint lat: 49.01513, lon: 12.10161, locations facility: Novartis Investigative Site, city: Rosenheim, state: Bayern, zip: 83022, country: Germany, geoPoint lat: 47.85637, lon: 12.12247, locations facility: Novartis Investigative Site, city: Straubing, state: Bayern, zip: 94315, country: Germany, geoPoint lat: 48.88126, lon: 12.57385, locations facility: Novartis Investigative Site, city: Wuerzburg, state: Bayern, zip: 97070, country: Germany, geoPoint lat: 49.79391, lon: 9.95121, locations facility: Novartis Investigative Site, city: Mannheim, state: Beden Wuerttenberg, zip: 68167, country: Germany, geoPoint lat: 49.4891, lon: 8.46694, locations facility: Novartis Investigative Site, city: Brandenburg A D Havel, state: Brandenburg, zip: 14770, country: Germany, locations facility: Novartis Investigative Site, city: Doberlug Kirchhain, state: Brandenburg, zip: 03253, country: Germany, geoPoint lat: 51.62578, lon: 13.56232, locations facility: Novartis Investigative Site, city: Fuerstenwalde, state: Brandenburg, zip: 15517, country: Germany, locations facility: Novartis Investigative Site, city: Ludwigsfelde, state: Brandenburg, zip: 14974, country: Germany, geoPoint lat: 52.30322, lon: 13.25405, locations facility: Novartis Investigative Site, city: Neu-Brandenburg, state: Brandenburg, zip: 17036, country: Germany, locations facility: Novartis Investigative Site, city: Spremberg, state: Brandenburg, zip: 03130, country: Germany, geoPoint lat: 51.56971, lon: 14.37355, locations facility: Novartis Investigative Site, city: Bremerhaven, state: Bremen, zip: 27576, country: Germany, geoPoint lat: 53.55021, lon: 8.57673, locations facility: Novartis Investigative Site, city: Bayern, state: Donauworth, zip: 86609, country: Germany, geoPoint lat: 47.795, lon: 12.53381, locations facility: Novartis Investigative Site, city: Baden-Württemberg, state: Heidenheim a.d.B, zip: 89522, country: Germany, locations facility: Novartis Investigative Site, city: Bad Homburg, state: Hessen, zip: 61352, country: Germany, geoPoint lat: 50.22683, lon: 8.61816, locations facility: Novartis Investigative Site, city: Bad Nauheim, state: Hessen, zip: 61231, country: Germany, geoPoint lat: 50.36463, lon: 8.73859, locations facility: Novartis Investigative Site, city: Darmstadt, state: Hessen, zip: 64283, country: Germany, geoPoint lat: 49.87167, lon: 8.65027, locations facility: Novartis Investigative Site, city: Erbach, state: Hessen, zip: 64711, country: Germany, geoPoint lat: 49.66148, lon: 8.99402, locations facility: Novartis Investigative Site, city: Langen, state: Hessen, zip: 63225, country: Germany, geoPoint lat: 49.98955, lon: 8.66852, locations facility: Novartis Investigative Site, city: Lich, state: Hessen, zip: 35423, country: Germany, geoPoint lat: 50.52085, lon: 8.81567, locations facility: Novartis Investigative Site, city: Marburg, state: Hessen, zip: 35043, country: Germany, geoPoint lat: 50.80904, lon: 8.77069, locations facility: Novartis Investigative Site, city: Arnsberg Huesten, state: Hochsauerland, zip: 59759, country: Germany, locations facility: Novartis Investigative Site, city: Twistringen, state: Lower Saxony, zip: 27239, country: Germany, geoPoint lat: 52.79926, lon: 8.64163, locations facility: Novartis Investigative Site, city: Rostock, state: Mecklenburg Vorpommern, zip: 18057, country: Germany, geoPoint lat: 54.0887, lon: 12.14049, locations facility: Novartis Investigative Site, city: Schwerin, state: Mecklenburg Vorpommern, zip: 19059, country: Germany, geoPoint lat: 53.62937, lon: 11.41316, locations facility: Novartis Investigative Site, city: Stralsund, state: Mecklenburg Vorpommern, zip: 18435, country: Germany, geoPoint lat: 54.30911, lon: 13.0818, locations facility: Novartis Investigative Site, city: Braunschweig, state: Niedersachsen, zip: 38100, country: Germany, geoPoint lat: 52.26594, lon: 10.52673, locations facility: Novartis Investigative Site, city: Buchholz, state: Niedersachsen, zip: 21244, country: Germany, geoPoint lat: 53.00884, lon: 9.56287, locations facility: Novartis Investigative Site, city: Damme, state: Niedersachsen, zip: 49401, country: Germany, geoPoint lat: 52.52157, lon: 8.19793, locations facility: Novartis Investigative Site, city: Georgsmarienhuette, state: Niedersachsen, zip: 49124, country: Germany, locations facility: Novartis Investigative Site, city: Hameln, state: Niedersachsen, zip: 31785, country: Germany, geoPoint lat: 52.10397, lon: 9.35623, locations facility: Novartis Investigative Site, city: Hannover, state: Niedersachsen, zip: 30171, country: Germany, geoPoint lat: 52.37052, lon: 9.73322, locations facility: Novartis Investigative Site, city: Lingen, state: Niedersachsen, zip: 49808, country: Germany, geoPoint lat: 52.52143, lon: 7.31845, locations facility: Novartis Investigative Site, city: Osnabrueck, state: Niedersachsen, zip: 49076, country: Germany, locations facility: Novartis Investigative Site, city: Quedlinburg, state: Niedersachsen, zip: 06484, country: Germany, geoPoint lat: 51.78843, lon: 11.15006, locations facility: Novartis Investigative Site, city: Westerstede, state: Niedersachsen, zip: 26655, country: Germany, geoPoint lat: 53.25682, lon: 7.92737, locations facility: Novartis Investigative Site, city: Wolfenbuettel, state: Niedersachsen, zip: 38304, country: Germany, locations facility: Novartis Investigative Site, city: Bergisch Gladbach, state: Nordrhein Westfalen, zip: 51465, country: Germany, geoPoint lat: 50.9856, lon: 7.13298, locations facility: Novartis Investigative Site, city: Bielefeld, state: Nordrhein Westfalen, zip: 33611, country: Germany, geoPoint lat: 52.03333, lon: 8.53333, locations facility: Novartis Investigative Site, city: Bielefeld, state: Nordrhein Westfalen, zip: 33615, country: Germany, geoPoint lat: 52.03333, lon: 8.53333, locations facility: Novartis Investigative Site, city: Bonn, state: Nordrhein Westfalen, zip: 53113, country: Germany, geoPoint lat: 50.73438, lon: 7.09549, locations facility: Novartis Investigative Site, city: Bonn, state: Nordrhein Westfalen, zip: 53177, country: Germany, geoPoint lat: 50.73438, lon: 7.09549, locations facility: Novartis Investigative Site, city: Dortmund, state: Nordrhein Westfalen, zip: 44137, country: Germany, geoPoint lat: 51.51494, lon: 7.466, locations facility: Novartis Investigative Site, city: Duesseldorf, state: Nordrhein Westfalen, zip: 40325, country: Germany, geoPoint lat: 51.22172, lon: 6.77616, locations facility: Novartis Investigative Site, city: Duesseldorf, state: Nordrhein Westfalen, zip: 40625, country: Germany, geoPoint lat: 51.22172, lon: 6.77616, locations facility: Novartis Investigative Site, city: Gelsenkirchen, state: Nordrhein Westfalen, zip: 45879, country: Germany, geoPoint lat: 51.50508, lon: 7.09655, locations facility: Novartis Investigative Site, city: Herdecke, state: Nordrhein Westfalen, zip: 58313, country: Germany, geoPoint lat: 51.39999, lon: 7.43584, locations facility: Novartis Investigative Site, city: Hilden, state: Nordrhein Westfalen, zip: 40724, country: Germany, geoPoint lat: 51.16818, lon: 6.93093, locations facility: Novartis Investigative Site, city: Krefeld, state: Nordrhein Westfalen, zip: 47805, country: Germany, geoPoint lat: 51.33645, lon: 6.55382, locations facility: Novartis Investigative Site, city: Lemgo, state: Nordrhein Westfalen, zip: 32657, country: Germany, geoPoint lat: 52.02786, lon: 8.89901, locations facility: Novartis Investigative Site, city: Neuss, state: Nordrhein Westfalen, zip: 41464, country: Germany, geoPoint lat: 51.19807, lon: 6.68504, locations facility: Novartis Investigative Site, city: Olpe, state: Nordrhein Westfalen, zip: 57462, country: Germany, geoPoint lat: 51.02899, lon: 7.85139, locations facility: Novartis Investigative Site, city: Paderborn, state: Nordrhein Westfalen, zip: 33098, country: Germany, geoPoint lat: 51.71905, lon: 8.75439, locations facility: Novartis Investigative Site, city: Siegen, state: Nordrhein Westfalen, zip: 57072, country: Germany, geoPoint lat: 50.87481, lon: 8.02431, locations facility: Novartis Investigative Site, city: Wesel, state: Nordrhein Westfalen, zip: 46483, country: Germany, geoPoint lat: 51.6669, lon: 6.62037, locations facility: Novartis Investigative Site, city: Wesel, state: Nordrhein Westfalen, zip: 46485, country: Germany, geoPoint lat: 51.6669, lon: 6.62037, locations facility: Novartis Investigative Site, city: Witten, state: Nordrhein Westfalen, zip: 58455, country: Germany, geoPoint lat: 51.44362, lon: 7.35258, locations facility: Novartis Investigative Site, city: Koeln, state: Nordrhein Westphalen, zip: 50179, country: Germany, geoPoint lat: 50.93333, lon: 6.95, locations facility: Novartis Investigative Site, city: Bochum, state: Nordrhein-Westfalen, zip: 44787, country: Germany, geoPoint lat: 51.48165, lon: 7.21648, locations facility: Novartis Investigative Site, city: Dortmund, state: Nordrhein-Westfalen, zip: 44309, country: Germany, geoPoint lat: 51.51494, lon: 7.466, locations facility: Novartis Investigative Site, city: Herne, state: Nordrhein-Westfalen, zip: 44649, country: Germany, geoPoint lat: 51.5388, lon: 7.22572, locations facility: Novartis Investigative Site, city: Remscheid, state: Nordrhein-Westfalen, zip: 42853, country: Germany, geoPoint lat: 51.17983, lon: 7.1925, locations facility: Novartis Investigative Site, city: Troisdorf, state: Nordrhein-Westfalen, zip: 53840, country: Germany, geoPoint lat: 50.80901, lon: 7.14968, locations facility: Novartis Investigative Site, city: Velbert, state: North Rhine-Westphalia, zip: 42551, country: Germany, geoPoint lat: 51.33537, lon: 7.04348, locations facility: Novartis Investigative Site, city: Hagen, state: Northrhine Westfalia, zip: 58095, country: Germany, geoPoint lat: 51.36081, lon: 7.47168, locations facility: Novartis Investigative Site, city: Remscheid Innen, state: Northrhine Westfalia, zip: 42859, country: Germany, locations facility: Novartis Investigative Site, city: Eggenfelde, state: Passau, zip: 84307, country: Germany, locations facility: Novartis Investigative Site, city: Mayen, state: Rheinland Pfalz, zip: 56727, country: Germany, geoPoint lat: 50.32797, lon: 7.22277, locations facility: Novartis Investigative Site, city: Simmern, state: Rheinland Pfalz, zip: 55469, country: Germany, geoPoint lat: 49.98198, lon: 7.52351, locations facility: Novartis Investigative Site, city: Neustadt, state: Rheinland-Pfalz, zip: 67434, country: Germany, geoPoint lat: 49.35009, lon: 8.13886, locations facility: Novartis Investigative Site, city: Magdeburg, state: Sachsen Anhalt, zip: 39108, country: Germany, geoPoint lat: 52.12773, lon: 11.62916, locations facility: Novartis Investigative Site, city: Magdeburg, state: Sachsen Anhalt, zip: 39130, country: Germany, geoPoint lat: 52.12773, lon: 11.62916, locations facility: Novartis Investigative Site, city: Dresden, state: Sachsen, zip: 01127, country: Germany, geoPoint lat: 51.05089, lon: 13.73832, locations facility: Novartis Investigative Site, city: Dresden, state: Sachsen, zip: 01307, country: Germany, geoPoint lat: 51.05089, lon: 13.73832, locations facility: Novartis Investigative Site, city: Leipzig, state: Sachsen, zip: 04103, country: Germany, geoPoint lat: 51.33962, lon: 12.37129, locations facility: Novartis Investigative Site, city: Pirna, state: Sachsen, zip: 01796, country: Germany, geoPoint lat: 50.95843, lon: 13.93702, locations facility: Novartis Investigative Site, city: Rodewisch, state: Sachsen, zip: 08228, country: Germany, geoPoint lat: 50.53083, lon: 12.41329, locations facility: Novartis Investigative Site, city: Scheibenberg, state: Sachsen, zip: 09481, country: Germany, geoPoint lat: 50.54023, lon: 12.91215, locations facility: Novartis Investigative Site, city: Schkeuditz, state: Sachsen, zip: 04435, country: Germany, geoPoint lat: 51.39678, lon: 12.22141, locations facility: Novartis Investigative Site, city: Zittau, state: Sachsen, zip: 02763, country: Germany, geoPoint lat: 50.89772, lon: 14.80764, locations facility: Novartis Investigative Site, city: Zxickau, state: Sachsen, zip: 08060, country: Germany, locations facility: Novartis Investigative Site, city: Flensburg, state: Schleswig Flensburg, zip: 24939, country: Germany, geoPoint lat: 54.78431, lon: 9.43961, locations facility: Novartis Investigative Site, city: Luebeck, state: Schleswig-Holstein, zip: 23563, country: Germany, geoPoint lat: 53.86893, lon: 10.68729, locations facility: Novartis Investigative Site, city: Apolda, state: Thueringen, zip: 99510, country: Germany, geoPoint lat: 51.02624, lon: 11.51638, locations facility: Novartis Investigative Site, city: Eisenach, state: Thueringen, zip: 99817, country: Germany, geoPoint lat: 50.9807, lon: 10.31522, locations facility: Novartis Investigative Site, city: Erfurt, state: Thueringen, zip: 99084, country: Germany, geoPoint lat: 50.9787, lon: 11.03283, locations facility: Novartis Investigative Site, city: Meinigen, state: Thueringen, zip: 98617, country: Germany, locations facility: Novartis Investigative Site, city: Suhl, state: Thueringen, zip: 98527, country: Germany, geoPoint lat: 50.60911, lon: 10.69401, locations facility: Novartis Investigative Site, city: Altoetting, zip: 84503, country: Germany, locations facility: Novartis Investigative Site, city: Augsburg, zip: 86150, country: Germany, geoPoint lat: 48.37154, lon: 10.89851, locations facility: Novartis Investigative Site, city: Augsburg, zip: 86179, country: Germany, geoPoint lat: 48.37154, lon: 10.89851, locations facility: Novartis Investigative Site, city: Bad Liebenwerda, zip: 04924, country: Germany, geoPoint lat: 51.51826, lon: 13.39459, locations facility: Novartis Investigative Site, city: Bamberg, zip: 96049, country: Germany, geoPoint lat: 49.89873, lon: 10.90067, locations facility: Novartis Investigative Site, city: Bayreuth, zip: 95445, country: Germany, geoPoint lat: 49.94782, lon: 11.57893, locations facility: Novartis Investigative Site, city: Berlin, zip: 10117, country: Germany, geoPoint lat: 52.52437, lon: 13.41053, locations facility: Novartis Investigative Site, city: Berlin, zip: 10317, country: Germany, geoPoint lat: 52.52437, lon: 13.41053, locations facility: Novartis Investigative Site, city: Berlin, zip: 10715, country: Germany, geoPoint lat: 52.52437, lon: 13.41053, locations facility: Novartis Investigative Site, city: Berlin, zip: 12487, country: Germany, geoPoint lat: 52.52437, lon: 13.41053, locations facility: Novartis Investigative Site, city: Berlin, zip: 13187, country: Germany, geoPoint lat: 52.52437, lon: 13.41053, locations facility: Novartis Investigative Site, city: Berlin, zip: 13353, country: Germany, geoPoint lat: 52.52437, lon: 13.41053, locations facility: Novartis Investigative Site, city: Berlin, zip: 13581, country: Germany, geoPoint lat: 52.52437, lon: 13.41053, locations facility: Novartis Investigative Site, city: Berlin, zip: 14169, country: Germany, geoPoint lat: 52.52437, lon: 13.41053, locations facility: Novartis Investigative Site, city: Berlin, zip: 14197, country: Germany, geoPoint lat: 52.52437, lon: 13.41053, locations facility: Novartis Investigative Site, city: Bochum, zip: 44791, country: Germany, geoPoint lat: 51.48165, lon: 7.21648, locations facility: Novartis Investigative Site, city: Boeblingen, zip: 71032, country: Germany, locations facility: Novartis Investigative Site, city: Bonn, zip: 53111, country: Germany, geoPoint lat: 50.73438, lon: 7.09549, locations facility: Novartis Investigative Site, city: Bonn, zip: 53113, country: Germany, geoPoint lat: 50.73438, lon: 7.09549, locations facility: Novartis Investigative Site, city: Bottrop, zip: 46236, country: Germany, geoPoint lat: 51.52392, lon: 6.9285, locations facility: Novartis Investigative Site, city: Brandenburg, zip: 14770, country: Germany, geoPoint lat: 52.41667, lon: 12.55, locations facility: Novartis Investigative Site, city: Bremen, zip: 28205, country: Germany, geoPoint lat: 53.07516, lon: 8.80777, locations facility: Novartis Investigative Site, city: Bremen, zip: 28209, country: Germany, geoPoint lat: 53.07516, lon: 8.80777, locations facility: Novartis Investigative Site, city: Bremen, zip: 28239, country: Germany, geoPoint lat: 53.07516, lon: 8.80777, locations facility: Novartis Investigative Site, city: Bremerhaven, zip: 27574, country: Germany, geoPoint lat: 53.55021, lon: 8.57673, locations facility: Novartis Investigative Site, city: Celle, zip: 29223, country: Germany, geoPoint lat: 52.62264, lon: 10.08047, locations facility: Novartis Investigative Site, city: Chemnitz, zip: 09113, country: Germany, geoPoint lat: 50.8357, lon: 12.92922, locations facility: Novartis Investigative Site, city: Chemnitz, zip: 09117, country: Germany, geoPoint lat: 50.8357, lon: 12.92922, locations facility: Novartis Investigative Site, city: Cottbus, zip: 03048, country: Germany, geoPoint lat: 51.75769, lon: 14.32888, locations facility: Novartis Investigative Site, city: Dessau Rosslau, zip: 06847, country: Germany, locations facility: Novartis Investigative Site, city: Dresden, zip: 01307, country: Germany, geoPoint lat: 51.05089, lon: 13.73832, locations facility: Novartis Investigative Site, city: Erfurt, zip: 99084, country: Germany, geoPoint lat: 50.9787, lon: 11.03283, locations facility: Novartis Investigative Site, city: Erlangen, zip: 91054, country: Germany, geoPoint lat: 49.59099, lon: 11.00783, locations facility: Novartis Investigative Site, city: Essen, zip: 45147, country: Germany, geoPoint lat: 51.45657, lon: 7.01228, locations facility: Novartis Investigative Site, city: Esslingen, zip: 73730, country: Germany, geoPoint lat: 48.73961, lon: 9.30473, locations facility: Novartis Investigative Site, city: Eutin, zip: 23701, country: Germany, geoPoint lat: 54.14054, lon: 10.60751, locations facility: Novartis Investigative Site, city: Frankfurt, zip: 60398, country: Germany, geoPoint lat: 50.11552, lon: 8.68417, locations facility: Novartis Investigative Site, city: Frankfurt, zip: 60431, country: Germany, geoPoint lat: 50.11552, lon: 8.68417, locations facility: Novartis Investigative Site, city: Frankfurt, zip: 65929, country: Germany, geoPoint lat: 50.11552, lon: 8.68417, locations facility: Novartis Investigative Site, city: Freiburg, zip: 79106, country: Germany, geoPoint lat: 47.9959, lon: 7.85222, locations facility: Novartis Investigative Site, city: Friedberg, zip: 86316, country: Germany, geoPoint lat: 48.35693, lon: 10.98461, locations facility: Novartis Investigative Site, city: Friedrichshafen, zip: 88045, country: Germany, geoPoint lat: 47.65689, lon: 9.47554, locations facility: Novartis Investigative Site, city: Gera, zip: 07548, country: Germany, geoPoint lat: 50.88029, lon: 12.08187, locations facility: Novartis Investigative Site, city: Goch, zip: 47574, country: Germany, geoPoint lat: 51.67873, lon: 6.15895, locations facility: Novartis Investigative Site, city: Goettingen, zip: 37073, country: Germany, locations facility: Novartis Investigative Site, city: Goettingen, zip: 37075, country: Germany, locations facility: Novartis Investigative Site, city: Goslar, zip: 38642, country: Germany, geoPoint lat: 51.90425, lon: 10.42766, locations facility: Novartis Investigative Site, city: Greifswald, zip: 17475, country: Germany, geoPoint lat: 54.09311, lon: 13.38786, locations facility: Novartis Investigative Site, city: Gummersbach, zip: 51643, country: Germany, geoPoint lat: 51.02608, lon: 7.56473, locations facility: Novartis Investigative Site, city: Halberstadt, zip: 38820, country: Germany, geoPoint lat: 51.89562, lon: 11.05622, locations facility: Novartis Investigative Site, city: Halle, zip: 06110, country: Germany, geoPoint lat: 51.48159, lon: 11.97948, locations facility: Novartis Investigative Site, city: Hamburg, zip: 20259, country: Germany, geoPoint lat: 53.57532, lon: 10.01534, locations facility: Novartis Investigative Site, city: Hamburg, zip: 20357, country: Germany, geoPoint lat: 53.57532, lon: 10.01534, locations facility: Novartis Investigative Site, city: Hamburg, zip: 22081, country: Germany, geoPoint lat: 53.57532, lon: 10.01534, locations facility: Novartis Investigative Site, city: Hamburg, zip: 22087, country: Germany, geoPoint lat: 53.57532, lon: 10.01534, locations facility: Novartis Investigative Site, city: Hamburg, zip: 22291, country: Germany, geoPoint lat: 53.57532, lon: 10.01534, locations facility: Novartis Investigative Site, city: Hamburg, zip: 22457, country: Germany, geoPoint lat: 53.57532, lon: 10.01534, locations facility: Novartis Investigative Site, city: Hameln, zip: 31785, country: Germany, geoPoint lat: 52.10397, lon: 9.35623, locations facility: Novartis Investigative Site, city: Hanau, zip: 63450, country: Germany, geoPoint lat: 50.13423, lon: 8.91418, locations facility: Novartis Investigative Site, city: Hannover, zip: 30161, country: Germany, geoPoint lat: 52.37052, lon: 9.73322, locations facility: Novartis Investigative Site, city: Hannover, zip: 30177, country: Germany, geoPoint lat: 52.37052, lon: 9.73322, locations facility: Novartis Investigative Site, city: Hannover, zip: 30625, country: Germany, geoPoint lat: 52.37052, lon: 9.73322, locations facility: Novartis Investigative Site, city: Hildesheim, zip: 31134, country: Germany, geoPoint lat: 52.15077, lon: 9.95112, locations facility: Novartis Investigative Site, city: Hof, zip: 95028, country: Germany, geoPoint lat: 50.31297, lon: 11.91261, locations facility: Novartis Investigative Site, city: Homburg, zip: 66421, country: Germany, geoPoint lat: 49.32637, lon: 7.33867, locations facility: Novartis Investigative Site, city: Ilsede, zip: 31241, country: Germany, geoPoint lat: 52.2634, lon: 10.19922, locations facility: Novartis Investigative Site, city: Jena, zip: 07740, country: Germany, geoPoint lat: 50.92878, lon: 11.5899, locations facility: Novartis Investigative Site, city: Kaiserslautern, zip: 67655, country: Germany, geoPoint lat: 49.443, lon: 7.77161, locations facility: Novartis Investigative Site, city: Karlsruhe, zip: 76133, country: Germany, geoPoint lat: 49.00937, lon: 8.40444, locations facility: Novartis Investigative Site, city: Karlsruhe, zip: 76135, country: Germany, geoPoint lat: 49.00937, lon: 8.40444, locations facility: Novartis Investigative Site, city: Kassel, zip: 34119, country: Germany, geoPoint lat: 51.31667, lon: 9.5, locations facility: Novartis Investigative Site, city: Kempten, zip: 87439, country: Germany, geoPoint lat: 47.72674, lon: 10.31389, locations facility: Novartis Investigative Site, city: Kiel, zip: 24105, country: Germany, geoPoint lat: 54.32133, lon: 10.13489, locations facility: Novartis Investigative Site, city: Koblenz, zip: 56068, country: Germany, geoPoint lat: 50.35357, lon: 7.57883, locations facility: Novartis Investigative Site, city: Koeln, zip: 50671, country: Germany, geoPoint lat: 50.93333, lon: 6.95, locations facility: Novartis Investigative Site, city: Koeln, zip: 50935, country: Germany, geoPoint lat: 50.93333, lon: 6.95, locations facility: Novartis Investigative Site, city: Koeln, zip: 50937, country: Germany, geoPoint lat: 50.93333, lon: 6.95, locations facility: Novartis Investigative Site, city: Koeln, zip: 51067, country: Germany, geoPoint lat: 50.93333, lon: 6.95, locations facility: Novartis Investigative Site, city: Kronach, zip: 96317, country: Germany, geoPoint lat: 50.23963, lon: 11.33308, locations facility: Novartis Investigative Site, city: Krumbach, zip: 86381, country: Germany, geoPoint lat: 48.24182, lon: 10.3632, locations facility: Novartis Investigative Site, city: Kulmbach, zip: 95326, country: Germany, geoPoint lat: 50.10068, lon: 11.45032, locations facility: Novartis Investigative Site, city: Lebach, zip: 66822, country: Germany, geoPoint lat: 49.41122, lon: 6.90988, locations facility: Novartis Investigative Site, city: Leipzig, zip: 04129, country: Germany, geoPoint lat: 51.33962, lon: 12.37129, locations facility: Novartis Investigative Site, city: Leipzig, zip: 04277, country: Germany, geoPoint lat: 51.33962, lon: 12.37129, locations facility: Novartis Investigative Site, city: Loerrach, zip: 79539, country: Germany, geoPoint lat: 47.61497, lon: 7.66457, locations facility: Novartis Investigative Site, city: Lohsa/Weißkollm, zip: 02999, country: Germany, locations facility: Novartis Investigative Site, city: Luebeck, zip: 23538, country: Germany, geoPoint lat: 53.86893, lon: 10.68729, locations facility: Novartis Investigative Site, city: Mainz, zip: 55131, country: Germany, geoPoint lat: 49.98419, lon: 8.2791, locations facility: Novartis Investigative Site, city: Mannheim, zip: 68161, country: Germany, geoPoint lat: 49.4891, lon: 8.46694, locations facility: Novartis Investigative Site, city: Mannheim, zip: 68165, country: Germany, geoPoint lat: 49.4891, lon: 8.46694, locations facility: Novartis Investigative Site, city: Marburg, zip: 35037, country: Germany, geoPoint lat: 50.80904, lon: 8.77069, locations facility: Novartis Investigative Site, city: Marktredwitz, zip: 95615, country: Germany, geoPoint lat: 50.00443, lon: 12.08593, locations facility: Novartis Investigative Site, city: Memmingen, zip: 87700, country: Germany, geoPoint lat: 47.98372, lon: 10.18527, locations facility: Novartis Investigative Site, city: Minden, zip: 32429, country: Germany, geoPoint lat: 52.28953, lon: 8.91455, locations facility: Novartis Investigative Site, city: Moenchengladbach, zip: 41061, country: Germany, geoPoint lat: 51.18539, lon: 6.44172, locations facility: Novartis Investigative Site, city: Moers, zip: 47441, country: Germany, geoPoint lat: 51.45342, lon: 6.6326, locations facility: Novartis Investigative Site, city: Muehlhausen, zip: 99974, country: Germany, locations facility: Novartis Investigative Site, city: Muenster, zip: 48145, country: Germany, geoPoint lat: 51.96236, lon: 7.62571, locations facility: Novartis Investigative Site, city: Naunhof, zip: 04683, country: Germany, geoPoint lat: 51.2777, lon: 12.58827, locations facility: Novartis Investigative Site, city: Neuruppin, zip: 16816, country: Germany, geoPoint lat: 52.92815, lon: 12.80311, locations facility: Novartis Investigative Site, city: Neuss, zip: 41462, country: Germany, geoPoint lat: 51.19807, lon: 6.68504, locations facility: Novartis Investigative Site, city: Neustadt/Sachsen, zip: 01844, country: Germany, locations facility: Novartis Investigative Site, city: Nordhausen, zip: 99734, country: Germany, geoPoint lat: 51.5018, lon: 10.7957, locations facility: Novartis Investigative Site, city: Nuernberg, zip: 90419, country: Germany, geoPoint lat: 49.45421, lon: 11.07752, locations facility: Novartis Investigative Site, city: Nuernberg, zip: 90449, country: Germany, geoPoint lat: 49.45421, lon: 11.07752, locations facility: Novartis Investigative Site, city: Offenbach, zip: 63069, country: Germany, geoPoint lat: 50.10061, lon: 8.76647, locations facility: Novartis Investigative Site, city: Offenburg, zip: 77654, country: Germany, geoPoint lat: 48.47377, lon: 7.94495, locations facility: Novartis Investigative Site, city: Oldenburg, zip: 26121, country: Germany, geoPoint lat: 53.14118, lon: 8.21467, locations facility: Novartis Investigative Site, city: Osnabrueck, zip: 49076, country: Germany, locations facility: Novartis Investigative Site, city: Passau, zip: 94036, country: Germany, geoPoint lat: 48.5665, lon: 13.43122, locations facility: Novartis Investigative Site, city: Pforzheim, zip: 75175, country: Germany, geoPoint lat: 48.88436, lon: 8.69892, locations facility: Novartis Investigative Site, city: Plauen-Kauschwitz, zip: 08525, country: Germany, locations facility: Novartis Investigative Site, city: Potsdam, zip: 14467, country: Germany, geoPoint lat: 52.39886, lon: 13.06566, locations facility: Novartis Investigative Site, city: Ravensburg, zip: 88214, country: Germany, geoPoint lat: 47.78198, lon: 9.61062, locations facility: Novartis Investigative Site, city: Regensburg, zip: 93053, country: Germany, geoPoint lat: 49.01513, lon: 12.10161, locations facility: Novartis Investigative Site, city: Rheine, zip: 48431, country: Germany, geoPoint lat: 52.28509, lon: 7.44055, locations facility: Novartis Investigative Site, city: Rodgau, zip: 63110, country: Germany, geoPoint lat: 50.02627, lon: 8.88588, locations facility: Novartis Investigative Site, city: Rostock, zip: 18057, country: Germany, geoPoint lat: 54.0887, lon: 12.14049, locations facility: Novartis Investigative Site, city: Rostock, zip: 18059, country: Germany, geoPoint lat: 54.0887, lon: 12.14049, locations facility: Novartis Investigative Site, city: Rotenburg, zip: 27356, country: Germany, geoPoint lat: 53.11125, lon: 9.41082, locations facility: Novartis Investigative Site, city: Ruesselsheim, zip: 65428, country: Germany, locations facility: Novartis Investigative Site, city: Saarbruecken, zip: 66113, country: Germany, geoPoint lat: 49.23262, lon: 7.0098, locations facility: Novartis Investigative Site, city: Saarlouis, zip: 66740, country: Germany, geoPoint lat: 49.31366, lon: 6.75154, locations facility: Novartis Investigative Site, city: Salzgitter, zip: 38226, country: Germany, geoPoint lat: 52.15256, lon: 10.33144, locations facility: Novartis Investigative Site, city: Schorndorf, zip: 73614, country: Germany, geoPoint lat: 48.80537, lon: 9.52721, locations facility: Novartis Investigative Site, city: Schweinfurt, zip: 97422, country: Germany, geoPoint lat: 50.04937, lon: 10.22175, locations facility: Novartis Investigative Site, city: Schwerte, zip: 58239, country: Germany, geoPoint lat: 51.44387, lon: 7.5675, locations facility: Novartis Investigative Site, city: Schwäbisch-Hall, zip: 74523, country: Germany, geoPoint lat: 49.11127, lon: 9.73908, locations facility: Novartis Investigative Site, city: Soest, zip: 59494, country: Germany, geoPoint lat: 51.57558, lon: 8.10619, locations facility: Novartis Investigative Site, city: Stade, zip: 21680, country: Germany, geoPoint lat: 53.59337, lon: 9.47629, locations facility: Novartis Investigative Site, city: Stendal, zip: 39576, country: Germany, geoPoint lat: 52.6069, lon: 11.85867, locations facility: Novartis Investigative Site, city: Stolberg, zip: 52222, country: Germany, geoPoint lat: 50.77368, lon: 6.22595, locations facility: Novartis Investigative Site, city: Stuttgart, zip: 70174, country: Germany, geoPoint lat: 48.78232, lon: 9.17702, locations facility: Novartis Investigative Site, city: Stuttgart, zip: 70199, country: Germany, geoPoint lat: 48.78232, lon: 9.17702, locations facility: Novartis Investigative Site, city: Suhl, zip: 98527, country: Germany, geoPoint lat: 50.60911, lon: 10.69401, locations facility: Novartis Investigative Site, city: Torgau, zip: 04860, country: Germany, geoPoint lat: 51.56016, lon: 12.99617, locations facility: Novartis Investigative Site, city: Trier, zip: 54290, country: Germany, geoPoint lat: 49.75565, lon: 6.63935, locations facility: Novartis Investigative Site, city: Tuebingen, zip: 72076, country: Germany, geoPoint lat: 48.52266, lon: 9.05222, locations facility: Novartis Investigative Site, city: Ulm, zip: 89073, country: Germany, geoPoint lat: 48.39841, lon: 9.99155, locations facility: Novartis Investigative Site, city: Ulm, zip: 89081, country: Germany, geoPoint lat: 48.39841, lon: 9.99155, locations facility: Novartis Investigative Site, city: Vechta, zip: 49377, country: Germany, geoPoint lat: 52.72632, lon: 8.28598, locations facility: Novartis Investigative Site, city: Voelklingen, zip: 66333, country: Germany, locations facility: Novartis Investigative Site, city: Weiden, zip: 92637, country: Germany, geoPoint lat: 49.67682, lon: 12.15613, locations facility: Novartis Investigative Site, city: Weinheim, zip: 69469, country: Germany, geoPoint lat: 49.54887, lon: 8.66697, locations facility: Novartis Investigative Site, city: Wetzlar, zip: 35578, country: Germany, geoPoint lat: 50.56109, lon: 8.50495, locations facility: Novartis Investigative Site, city: Wiesbaden, zip: 65189, country: Germany, geoPoint lat: 50.08258, lon: 8.24932, locations facility: Novartis Investigative Site, city: Wiesbaden, zip: 65191, country: Germany, geoPoint lat: 50.08258, lon: 8.24932, locations facility: Novartis Investigative Site, city: Wilhelmshaven, zip: 26389, country: Germany, geoPoint lat: 53.52998, lon: 8.11253, locations facility: Novartis Investigative Site, city: Wolfsburg, zip: 38440, country: Germany, geoPoint lat: 52.42452, lon: 10.7815, locations facility: Novartis Investigative Site, city: Worms, zip: 67550, country: Germany, geoPoint lat: 49.63278, lon: 8.35916, locations facility: Novartis Investigative Site, city: Wuerselen, zip: 52146, country: Germany, locations facility: Novartis Investigative Site, city: Wuerzburg, zip: 97080, country: Germany, geoPoint lat: 49.79391, lon: 9.95121, hasResults: False