protocolSection identificationModule nctId: NCT06387784, orgStudyIdInfo id: 2024/823, briefTitle: Acute Beetroot Juice Supplementation in Pre-eclampsia Pregnancies, acronym: BEET_PE, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-06, primaryCompletionDateStruct date: 2024-12, completionDateStruct date: 2025-06, studyFirstPostDateStruct date: 2024-04-29, lastUpdatePostDateStruct date: 2024-04-29, sponsorCollaboratorsModule leadSponsor name: University of Sao Paulo, class: OTHER, collaborators name: Hospital das Clínicas de Ribeirão Preto, collaborators name: Universidade Estadual Paulista Júlio de Mesquita Filho, descriptionModule briefSummary: Pre-eclampsia is a serious condition that typically affects pregnant women after the 20th week of pregnancy, characterized by high blood pressure and damage to organs such as the kidneys and liver. Currently, treatment options are limited, which has prompted researchers to explore alternative approaches. One such promising alternative is dietary nitrate found in vegetables like beetroot, as nitrate can be converted into nitric oxide in the body, which helps lower blood pressure. This study aims to determine the acute effects of nitrate-rich beetroot juice on blood pressure, several blood and salivary markers in pregnant women with pre-eclampsia. Furthermore, the study will assess fetal blood flow using Doppler ultrasound. The investigators want to understand the kinetics of nitrate and nitric oxide metabolites and assess the temporal dependency of the hypotensive response. Through this investigation, the investigators seek evidence of nitrate-enriched beetroot juice as an adjunct therapy in managing pre-eclampsia., conditionsModule conditions: Pre-Eclampsia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized, placebo-controlled, single-blind, parallel-group study assessing acute rich-nitrate juice on pregnant women diagnosed with early and late-onset pre-eclampsia. Participants will be divided into four distinct groups: two groups for each onset category. Within each group, participants will be further divided into a control group and a treated group. The assignment of participants to these groups will be randomized using an online program., primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 96, type: ESTIMATED, armsInterventionsModule interventions name: Beetroot juice, interventions name: Placebo juice, outcomesModule primaryOutcomes measure: Acute Effect of Beetroot Juice Supplementation on Blood Pressure, secondaryOutcomes measure: Plasma Concentrations of Nitric Oxide Metabolites, secondaryOutcomes measure: Concentration of Salivary Nitrate Reductase Enzyme, secondaryOutcomes measure: Plasma Lipid Peroxidation Levels, secondaryOutcomes measure: Concentration of Total Antioxidant Capacity in Plasma, secondaryOutcomes measure: Maternal Blood Flow Velocity, secondaryOutcomes measure: Fetal Heart Rate, secondaryOutcomes measure: Umbilical Arterial Pulsatility Index, eligibilityModule sex: FEMALE, minimumAge: 18 Years, maximumAge: 40 Years, stdAges: ADULT, contactsLocationsModule, hasResults: False