hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06277700, orgStudyIdInfo id: CMT001, briefTitle: Effects Of Dynamic Stabilizatıon Exercises And HVLA Manipulatıon in Low Back Paın, acronym: DNSHVLA, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-01, primaryCompletionDateStruct date: 2024-03-01, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-02-26, lastUpdatePostDateStruct date: 2024-02-26, sponsorCollaboratorsModule leadSponsor name: SEFA HAKTAN HATIK, class: OTHER, descriptionModule briefSummary: Our aim is to contribute to the literature by comparatively examining the effects of DNS exercises and chiropractic HVLA manipulation on pain, pain-related functional impairment (disability), physical competence level, dynamic fitness level of core muscles and postural deviations in patients with chronic nonspecific low back pain., conditionsModule conditions: Low Back Pain, conditions: Neuromuscular Subluxation of Joint, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: 60 people will participate in the study and the participants will be divided into four groups. The groups will be formed as chiropractic manipulation (CM) group (n=15), dynamic neuromuscular stabilization (DNS) group (n=15), CM + DNS group (n=15) and control group (CG) (n=15). Chiropractic manipulation will be performed once in the side-lying position. An individualized exercise program will be applied to the DNS group under the supervision of a physiotherapist. Kruskal Wallis test for comparisons of quantitative variables between 4 independent groups; Mann Whitney U test with Bonferonni correction will be used in double subgroup comparisons of significant variables. Friedman test was used for comparisons of quantitative variables in 3 dependent groups. Wilcoxon test with Bonferonni correction will be used for two-way subgroup comparisons for significant variables. In all statistical analyzes in the study, results with a p value below 0.05 will be considered statistically significant., primaryPurpose: BASIC_SCIENCE, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule interventions name: Chiropractic Manipulation (HVLA - high velocity low amplitude), interventions name: Dynamic Neuromuscular Stabilization, outcomesModule primaryOutcomes measure: Visual Analog Scale, primaryOutcomes measure: Physical Adequacy Level, primaryOutcomes measure: Disability Level, primaryOutcomes measure: Dynamic Stabilization and Adaptibility, primaryOutcomes measure: Posture, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 45 Years, stdAges: ADULT, contactsLocationsModule locations facility: Sefa Haktan Haktik, city: Sinop, country: Turkey, geoPoint lat: 42.02683, lon: 35.16253, hasResults: False
protocolSection identificationModule nctId: NCT06277674, orgStudyIdInfo id: ZF2023-252, briefTitle: Efficacy of Cadonilimab in Non-squamous Non-small Cell Lung Cancer Patients Resistant to EGFR-TKI, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-11-02, primaryCompletionDateStruct date: 2024-12, completionDateStruct date: 2025-06, studyFirstPostDateStruct date: 2024-02-26, lastUpdatePostDateStruct date: 2024-03-08, sponsorCollaboratorsModule leadSponsor name: Guangzhou University of Traditional Chinese Medicine, class: OTHER, collaborators name: Akeso Pharmaceuticals, Inc., descriptionModule briefSummary: This study was designed to evaluate the efficacy and safety of cadonilimab (anti PD-1 and CTLA-4 bispecific antibody) in combination with pemetrexed and anlotinib for treatment of elderly patients with T790M-negative advanced non-squamous non-small cell lung cancer following resistance to EGFR-TKI., conditionsModule conditions: Non-small Cell Lung Cancer, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 20, type: ESTIMATED, armsInterventionsModule interventions name: Cadonilimab plus Pemetrexed and Anlotinib, outcomesModule primaryOutcomes measure: ORR(Objective response rate), secondaryOutcomes measure: Progression-free survival (PFS), secondaryOutcomes measure: (Disease control rate assessed by investigators) DCR (CR+PR+SD), secondaryOutcomes measure: Overall survival (OS), eligibilityModule sex: ALL, minimumAge: 65 Years, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Guangdong Provincial Hospital of Traditional Chinese Medicine, status: RECRUITING, city: Guangzhou, state: Guangdong, zip: 510120, country: China, contacts name: Haibo Zhang, Prof, role: CONTACT, phone: 86-020-81887233, phoneExt: 34830, email: haibozh@gzucm.edu.cn, geoPoint lat: 23.11667, lon: 113.25, hasResults: False
protocolSection identificationModule nctId: NCT06277661, orgStudyIdInfo id: 2023H0305, briefTitle: The Mom and Infant Outcomes (MOMI) Study, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-05-01, primaryCompletionDateStruct date: 2027-06-30, completionDateStruct date: 2028-05-30, studyFirstPostDateStruct date: 2024-02-26, lastUpdatePostDateStruct date: 2024-04-09, sponsorCollaboratorsModule leadSponsor name: Ohio State University, class: OTHER, descriptionModule briefSummary: The investigator's long-term goal is to mitigate pregnancy-related mortality (PRM) risk by systematically delivering integrated clinical and supportive care that is effective, equitable, and scalable. The investigator's central hypothesis is that the Multi-modal Maternal Infant Perinatal Outpatient Delivery System (MOMI PODS) will mitigate postpartum (PP) risk and reduce disparities in PP risk by improving biopsychosocial profiles and facilitating access to evidence-based clinical and supportive care. To test this hypothesis, the investigators will conduct a hybrid type 1 randomized controlled trial (RCT) of MOMI PODS versus enhanced usual care (EUC, which we will term MOMI CARE) among a total sample of 384 mother-infant dyads (192/group) following pregnancy affected by a cardiometabolic and/or mental health condition. The investigators will enroll participants on PP day 1 and collect data at baseline and 6 months and 1 year PP. The investigators will collect implementation and service data across sites., conditionsModule conditions: Postpartum Depression, conditions: Postpartum Anxiety, conditions: Cardiometabolic Syndrome, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: PREVENTION, maskingInfo masking: NONE, enrollmentInfo count: 384, type: ESTIMATED, armsInterventionsModule interventions name: MOMI PODS, interventions name: Enhanced Usual Care (EUC), outcomesModule primaryOutcomes measure: Change in Life's Essential 8 (LE8) Composite Score, primaryOutcomes measure: Change in Life's Essential 8 (LE8) Composite Score, primaryOutcomes measure: Change in Life's Essential 8 (LE8) Composite Score, primaryOutcomes measure: Change in Patient Health Questionnaire-9 (PHQ-9) Score, primaryOutcomes measure: Change in Patient Health Questionnaire-9 (PHQ-9) Score, primaryOutcomes measure: Change in Patient Health Questionnaire-9 (PHQ-9) Score, primaryOutcomes measure: Change in Generalized Anxiety Disorder-7 (GAD-7) Score, primaryOutcomes measure: Change in Generalized Anxiety Disorder-7 (GAD-7) Score, primaryOutcomes measure: Change in Generalized Anxiety Disorder-7 (GAD-7) Score, eligibilityModule sex: FEMALE, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: The Ohio State University, city: Columbus, state: Ohio, zip: 43210, country: United States, contacts name: Shannon L. Gillespie, PhD, RN, role: CONTACT, phone: 614-292-4589, email: gillespie.175@osu.edu, contacts name: Sandra Solove, MA, role: CONTACT, phone: 6142478366, email: solove.3@osu.edu, geoPoint lat: 39.96118, lon: -82.99879, hasResults: False
protocolSection identificationModule nctId: NCT06277648, orgStudyIdInfo id: 18-2021, briefTitle: the Pericapsular Nerve Group (PENG) and Suprainguinal Fascia Iliaca Blocks (SIFIB) in Elderly Patients, statusModule overallStatus: RECRUITING, startDateStruct date: 2022-01-01, primaryCompletionDateStruct date: 2024-04-01, completionDateStruct date: 2024-04-15, studyFirstPostDateStruct date: 2024-02-26, lastUpdatePostDateStruct date: 2024-02-28, sponsorCollaboratorsModule leadSponsor name: Haseki Training and Research Hospital, class: OTHER, descriptionModule briefSummary: This clinical trial aims to compare the effect of the pericapsular nerve group (PENG) and suprainguinal fascia iliaca blocks (SIFIB) on pain management in elderly patients with subtrochanteric femur fractures.The participants will be patients determined to have proximal femoral nailing. According to randomisation, each participant will receive either PENG or SIFIB postoperatively after spinal anaesthesia. The investigator will measure postoperative pain scores, total amount of analgesic consumption and motor ability postoperatively., conditionsModule conditions: Collum Femoris Fracture, conditions: Pericapsular Nerve Group Block, conditions: Suprainguinal Fascia Iliaca Block, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: a double-blind, prospective, randomized, controlled study, primaryPurpose: SUPPORTIVE_CARE, maskingInfo masking: DOUBLE, maskingDescription: The orthopaedic surgeon responsible for the study was blinded to the study groups. This surgeon was the sole evaluator of postoperative pain scores and total analgesia consumption., whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 75, type: ESTIMATED, armsInterventionsModule interventions name: PENG block, interventions name: SIFIB, outcomesModule primaryOutcomes measure: pain scores, secondaryOutcomes measure: rescue analgesia, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 100 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Haseki Training and Research Hospital, status: RECRUITING, city: Istanbul, state: Sultangazi, country: Turkey, contacts name: Berna Caliskan, role: CONTACT, email: caliskan.b@gmail.com, geoPoint lat: 41.01384, lon: 28.94966, hasResults: False
protocolSection identificationModule nctId: NCT06277635, orgStudyIdInfo id: TAPAC001, briefTitle: Effect of Silymarin Against Methotrexate-induced Liver Injury in Rheumatic Diseases, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-01, primaryCompletionDateStruct date: 2025-04, completionDateStruct date: 2025-04, studyFirstPostDateStruct date: 2024-02-26, lastUpdatePostDateStruct date: 2024-02-26, sponsorCollaboratorsModule leadSponsor name: Phramongkutklao College of Medicine and Hospital, class: OTHER, descriptionModule briefSummary: To study the effect of silymarin against methotrexate-induced liver injury in rheumatic diseases including rheumatoid arthritis, psoriatric arthritis and psoriasis, conditionsModule conditions: Rheumatoid Arthritis, conditions: Psoriatic Arthritis, conditions: Psoriasis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: CARE_PROVIDER, enrollmentInfo count: 72, type: ESTIMATED, armsInterventionsModule interventions name: Silymarin, interventions name: Placebo, outcomesModule primaryOutcomes measure: AST or ALT > 1X ULN ( normal AST and ALT 0-50 U/L), secondaryOutcomes measure: AST or ALT > 2X ULN ( normal AST and ALT 0-50 U/L) AST or ALT > 2X ULN AST or ALT > 2X ULN, secondaryOutcomes measure: AST or ALT > 3X ULN ( normal AST and ALT 0-50 U/L), secondaryOutcomes measure: AST or ALT > 5X ULN or >3X ULN ( normal AST and ALT 0-50 U/L) with symptom of hepatitis such as Fatique, abdominal pain, nausea, vomiting or total bilirubin > 2X with jaundice, secondaryOutcomes measure: Discontinuation rate of methotrexate, secondaryOutcomes measure: Adverse events, secondaryOutcomes measure: Change of DAS-28 ESR or CRP Score, secondaryOutcomes measure: Change of BASDAI Score, secondaryOutcomes measure: Change of ASDAS ESR or CRP Score, secondaryOutcomes measure: Change of BSA for psoriasis, eligibilityModule sex: ALL, minimumAge: 20 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Rheumatic Disease Unit, Department of Internal Medicine, Phramongkutklao Hospital and College of Medicine, status: RECRUITING, city: Bangkok, Thailand, 10400, state: Bangkok, zip: 10400, country: Thailand, contacts name: Rattapol Pakchotanon, M.D., role: CONTACT, phone: 66+23547980, email: rattapolpmk@gmail.com, contacts name: Rattapol Pakchotanon, M.D., role: SUB_INVESTIGATOR, contacts name: Supasa Niyompanichakarn, M.D., role: SUB_INVESTIGATOR, geoPoint lat: 13.75398, lon: 100.50144, hasResults: False
protocolSection identificationModule nctId: NCT06277622, orgStudyIdInfo id: PekingUTH ZFCY PFUN, briefTitle: A Prospective Multicenter Cohort Study About Internal Fixation Using PFUN Versus PFNA for Femoral Intertrochanteric Fracture, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-01-01, primaryCompletionDateStruct date: 2025-09-30, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-02-26, lastUpdatePostDateStruct date: 2024-02-26, sponsorCollaboratorsModule leadSponsor name: Peking University Third Hospital, class: OTHER, collaborators name: Beijing Yanqing Hospital, descriptionModule briefSummary: This prospective multicenter cohort study is to compare the post-operative implant failure rate between the patients with femoral intertrochanteric fracture (AO classification 31-A) using Proximal Femoral Universal Nail (PFUN) versus Proximal Femoral Nail Antirotation (PFNA) at 21-month follow up. The patients are divided into the PFUN group and the PFNA group according to the internal fixation they choose. The internal fixation failure rate (IFFR) and differences in fracture prognosis of the two groups will be compared. Obtain clinical data of PFUN in the Chinese population, and verify the safety and efficacy of PFUN for patients with femoral intertrochanteric fracture., conditionsModule conditions: Femoral Intertrochanteric Fractures, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NON_RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: This prospective multicenter cohort study is to compare the post-operative implant failure rate between the patients with femoral intertrochanteric fracture (AO classification 31-A) using Proximal Femoral Universal Nail (PFUN) versus Proximal Femoral Nail Antirotation (PFNA) at 21-month follow up.The patients are divided into the PFUN group and the PFNA group according to the internal fixation they choose., primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 130, type: ESTIMATED, armsInterventionsModule interventions name: PFUN, interventions name: PFNA, outcomesModule primaryOutcomes measure: Internal fixation failure rate, secondaryOutcomes measure: Number of Participants with Bone nonunion, secondaryOutcomes measure: Harris hip score, secondaryOutcomes measure: operation time, secondaryOutcomes measure: The times of intraoperative fluoroscopy, secondaryOutcomes measure: Number of Participants with Postoperative adverse events, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 100 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Peking University Third Hospital, status: RECRUITING, city: Beijing, state: Beijing, zip: 100191, country: China, contacts name: Yuan Cao, MD, role: CONTACT, phone: +86-01082266699, email: cy6415@126.com, contacts name: Fang Zhou, MD, role: CONTACT, phone: +86010-82267010, email: zhouf@bjmu.edu.cn, geoPoint lat: 39.9075, lon: 116.39723, hasResults: False
protocolSection identificationModule nctId: NCT06277609, orgStudyIdInfo id: 20508A, briefTitle: A Trial Investigating Lu AF28996 in Healthy Adult Participants, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-27, primaryCompletionDateStruct date: 2024-05-18, completionDateStruct date: 2024-05-18, studyFirstPostDateStruct date: 2024-02-26, lastUpdatePostDateStruct date: 2024-03-07, sponsorCollaboratorsModule leadSponsor name: H. Lundbeck A/S, class: INDUSTRY, descriptionModule briefSummary: The purpose of this study is to investigate repeated doses of Lu AF28996 in healthy participants and co-administered with two other compounds, and in a separate cohort following co-administration with antibiotics, to see how well the doses are tolerated and what the body does to the drug after administering it., conditionsModule conditions: Healthy Participants, designModule studyType: INTERVENTIONAL, phases: PHASE1, designInfo allocation: NON_RANDOMIZED, interventionModel: SEQUENTIAL, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 24, type: ESTIMATED, armsInterventionsModule interventions name: Lu AF28996, interventions name: Acetylsalicylic Acid, interventions name: Mefenamic Acid, interventions name: Amoxicillin/clavulanic acid, outcomesModule primaryOutcomes measure: Maximum Observed Concentration (Cmax) of Lu AF28996, primaryOutcomes measure: Area Under the Plasma Concentration-Time Curve From Time 0 to Infinity (AUC0-inf) of Lu AF28996, secondaryOutcomes measure: Nominal Time Corresponding to the Occurrence of Cmax, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: Covance Dallas CRU, status: RECRUITING, city: Dallas, state: Texas, zip: 75247, country: United States, geoPoint lat: 32.78306, lon: -96.80667, hasResults: False
protocolSection identificationModule nctId: NCT06277596, orgStudyIdInfo id: ETK00-2023-0101, briefTitle: The Effects of Progressive Clinical Pilates Exercises Applied as 2 Different Ways in Fibromyalgia, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-04-10, primaryCompletionDateStruct date: 2024-07-30, completionDateStruct date: 2024-08-30, studyFirstPostDateStruct date: 2024-02-26, lastUpdatePostDateStruct date: 2024-04-16, sponsorCollaboratorsModule leadSponsor name: Eastern Mediterranean University, class: OTHER, descriptionModule briefSummary: The aim of this study is to compare the effects of progressive clinical Pilates exercises applied as group under the supervision of a physiotherapist and home exercise programs on pain level, physical condition, functional status, psychosocial status and quality of life in individuals with fibromyalgia between the ages of 20-50., conditionsModule conditions: Fibromyalgia, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 48, type: ESTIMATED, armsInterventionsModule interventions name: Exercise, outcomesModule primaryOutcomes measure: Visual Analog Scale ( VAS ), secondaryOutcomes measure: Sociodemographic information (age), secondaryOutcomes measure: Sociodemographic information (height), secondaryOutcomes measure: Sociodemographic information (weight), secondaryOutcomes measure: Trunk Muscle Endurance (McGill Endurance Test and Plank Test), secondaryOutcomes measure: Chair Sit to stand test, secondaryOutcomes measure: 6 minute walk test, secondaryOutcomes measure: Fatigue Severity Scale, secondaryOutcomes measure: Pittsburgh Sleep Quality Index, secondaryOutcomes measure: Revised Fibromyalgia Impact Questionnaire, secondaryOutcomes measure: Fear-Avoidance Beliefs Questionnaire, secondaryOutcomes measure: Pain Self-Efficacy Questionnaire, secondaryOutcomes measure: Body Awareness Questionnaire, secondaryOutcomes measure: Cognitive Exercise Therapy Approach-Biopsyhosocial Questionnaire (BETY-BQ), secondaryOutcomes measure: Short form-36 (SF-36), secondaryOutcomes measure: Treatment Satisfaction Evaluation, eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 50 Years, stdAges: ADULT, contactsLocationsModule locations facility: Eastern Mediterranean University, status: RECRUITING, city: Famagusta, zip: 99628, country: Cyprus, contacts name: Sevim Oksüz, Asst.Prof.Dr, role: CONTACT, phone: 5488351465, phoneExt: +90, email: sevim.oksuz@emu.edu.tr, geoPoint lat: 35.12054, lon: 33.93894, hasResults: False
protocolSection identificationModule nctId: NCT06277570, orgStudyIdInfo id: 2023-487, briefTitle: Investigation of the Effect of Superimposed Neuromuscular Electrical Stimulation in Patients With Knee Osteoarthritis., statusModule overallStatus: RECRUITING, startDateStruct date: 2023-10-31, primaryCompletionDateStruct date: 2025-03-31, completionDateStruct date: 2025-06-30, studyFirstPostDateStruct date: 2024-02-26, lastUpdatePostDateStruct date: 2024-02-26, sponsorCollaboratorsModule leadSponsor name: Gulhane School of Medicine, class: OTHER, descriptionModule briefSummary: The aim of the study is to investigate the effects of superimposed neuromuscular electrical stimulation with active contraction on physical function, muscle and joint structure, functionality, and quality of life in patients with knee osteoarthritis., conditionsModule conditions: Knee Osteoarthritis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: The sample of the study will consist of participants who applied to Etlik City Physical Therapy and Rehabilitation Hospital, were diagnosed with knee osteoarthritis by the physician, and will receive routine treatment in the electrotherapy unit. Patients will be randomly assigned to groups., primaryPurpose: TREATMENT, maskingInfo masking: DOUBLE, whoMasked: PARTICIPANT, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 63, type: ESTIMATED, armsInterventionsModule interventions name: conventional physiotherapy, interventions name: NMES, interventions name: Superimposed NMES, outcomesModule primaryOutcomes measure: Muscle strength, secondaryOutcomes measure: Joint position sense, secondaryOutcomes measure: Muscle structure and knee joint cartilage thickness, secondaryOutcomes measure: Joint range of motion, secondaryOutcomes measure: Short Form-36, secondaryOutcomes measure: Western Ontario and McMaster Universities Osteoarthritis Index Scale, secondaryOutcomes measure: Visual Analog Scale (VAS), secondaryOutcomes measure: Balance assessment, secondaryOutcomes measure: Functional capacity, eligibilityModule sex: ALL, minimumAge: 40 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Faculty of Physiotherapy and Rehabilitation, University of Health Sciences, status: RECRUITING, city: Ankara, state: Etlik, zip: 06018, country: Turkey, contacts name: Oğuzhan METE, role: CONTACT, email: oguzhan.mete@sbu.edu.tr, geoPoint lat: 39.91987, lon: 32.85427, hasResults: False