hackint0sh/temp-data huggingface dataset:
protocolSection identificationModule nctId: NCT06309914, orgStudyIdInfo id: Pro00074459, briefTitle: The Effects of Mirtoselect®, Virtiva®, and Enovita® on Cognitive Performance and Mood States, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-21, primaryCompletionDateStruct date: 2024-03-15, completionDateStruct date: 2024-05-06, studyFirstPostDateStruct date: 2024-03-13, lastUpdatePostDateStruct date: 2024-03-13, sponsorCollaboratorsModule leadSponsor name: Applied Science & Performance Institute, class: INDUSTRY, descriptionModule briefSummary: This is a randomized, double-blind, placebo-controlled, 4-week intervention clinical study assessing the efficacy of Mirtoselect®, Virtiva® Plus, and Enovita® on cognitive performance and mood states, and the occurrence of adverse events in response to daily supplementation. The desired sample size for this study is 64 subjects. To account for potential dropouts, we aim to enroll up to 20% over the desired sample size. Therefore, this study will enroll up to 76 healthy men and women (25-55 years of age). Subjects will be randomly divided into four study groups: Placebo, Virtiva® ginkgo biloba extract, Mirtoselect® bilberry extract, or Enovita® grape seed extract. Blocked randomization will be deployed in which subjects are divided into blocks of 4 subjects and each subject within a block is randomly assigned to one of the four study groups., conditionsModule conditions: Mental Processes, conditions: Cognitive Change, conditions: Mood Change, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, primaryPurpose: TREATMENT, maskingInfo masking: TRIPLE, whoMasked: PARTICIPANT, whoMasked: INVESTIGATOR, whoMasked: OUTCOMES_ASSESSOR, enrollmentInfo count: 76, type: ESTIMATED, armsInterventionsModule interventions name: Placebo, interventions name: Enovita Grape Seed Extract, interventions name: Mirtoselect Bilberry Extract, interventions name: Virtiva Plus Ginko Biloba Extract, outcomesModule primaryOutcomes measure: Change in Visual Memory, primaryOutcomes measure: Change in Verbal Memory, primaryOutcomes measure: Change in Finger Tapping Test (FTT) Results, primaryOutcomes measure: Change in Symbol Digit Coding (SDC) Test Results, primaryOutcomes measure: Change in Stroop Test Results, primaryOutcomes measure: Change in Shifting Attention Test Results, primaryOutcomes measure: Change in Continuous Performance Test Results, secondaryOutcomes measure: Change in Abbreviated Profile of Mood States (POMS) Score, eligibilityModule sex: ALL, minimumAge: 25 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: Applied Science and Performance Institute, status: RECRUITING, city: Tampa, state: Florida, zip: 33607, country: United States, contacts name: Jacob Wilson, PhD, role: CONTACT, phone: 813-673-8888, email: jwilson@theaspi.com, contacts name: Justine Davis, MS, role: CONTACT, phone: 813-673-8888, email: jdavis@theaspi.com, geoPoint lat: 27.94752, lon: -82.45843, hasResults: False
protocolSection identificationModule nctId: NCT06309901, orgStudyIdInfo id: ankaraYBU2019-199, briefTitle: Facial Distortion Model and Instrument Assisted Soft Tissue Mobilization Techniques, statusModule overallStatus: COMPLETED, startDateStruct date: 2019-06-30, primaryCompletionDateStruct date: 2021-12-01, completionDateStruct date: 2022-05-31, studyFirstPostDateStruct date: 2024-03-13, lastUpdatePostDateStruct date: 2024-03-13, sponsorCollaboratorsModule leadSponsor name: Ankara Yildirim Beyazıt University, class: OTHER, descriptionModule briefSummary: To compare the effects of facial distortion model and equipment assisted soft tissue mobilization techniques on the treatment process, which are among the applications in the rehabilitation process after meniscus repair., conditionsModule conditions: Meniscus Injury, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 33, type: ACTUAL, armsInterventionsModule interventions name: Exercise, interventions name: Fascial Distortion Model, interventions name: Instrument Assisted Soft Tissue Mobilisation, outcomesModule primaryOutcomes measure: Visual Analog Scale, primaryOutcomes measure: environmental measurement, primaryOutcomes measure: Power Track Manuel Muscle Tester, primaryOutcomes measure: sit and reach test, primaryOutcomes measure: Goniometric measurement, primaryOutcomes measure: The Western Ontario Meniscal Evaluation Tool (WOMET ), primaryOutcomes measure: Lysholm Knee Score, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 55 Years, stdAges: ADULT, contactsLocationsModule locations facility: Yıldırım Beyazıt University Yenimahalle Training and Research Hospital, city: Ankara, zip: 06010, country: Turkey, geoPoint lat: 39.91987, lon: 32.85427, hasResults: False
protocolSection identificationModule nctId: NCT06309888, orgStudyIdInfo id: 2023-18, briefTitle: Magnetic Resonance Imaging of Cognitive Deficits in the Brain of Individuals With Spinal Cord Injury, acronym: SCI_Cog, statusModule overallStatus: RECRUITING, startDateStruct date: 2024-02-01, primaryCompletionDateStruct date: 2026-12, completionDateStruct date: 2026-12, studyFirstPostDateStruct date: 2024-03-13, lastUpdatePostDateStruct date: 2024-03-13, sponsorCollaboratorsModule leadSponsor name: Swiss Paraplegic Research, Nottwil, class: NETWORK, descriptionModule briefSummary: In the case of spinal cord injury, rehabilitation is particularly focused on motor skills. Non-motor impairments such as thinking difficulties did not receive a lot of attention to date.In this research project, the investigators want to find out how thinking difficulties become noticeable in the brain with spinal cord injury.Participation procedure: Participants who take part will be asked to come to an examination once. The duration of the examination is between 2 and 2.5 hours (including around 55 minutes in the magnetic resonance imaging scanner, including preparation and follow-up)., conditionsModule conditions: Spinal Cord Injury, designModule studyType: OBSERVATIONAL, designInfo observationalModel: CASE_CONTROL, timePerspective: CROSS_SECTIONAL, enrollmentInfo count: 60, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Brain activity, secondaryOutcomes measure: Behavioral performance, secondaryOutcomes measure: Behavioral performance, secondaryOutcomes measure: Behavioral performance, secondaryOutcomes measure: Behavioral performance, secondaryOutcomes measure: Behavioral performance, secondaryOutcomes measure: Brain morphometry, secondaryOutcomes measure: Level of life satisfaction, secondaryOutcomes measure: Level of anxiety, secondaryOutcomes measure: Level of pain, secondaryOutcomes measure: Quality of sleep, secondaryOutcomes measure: Level of attention and awareness, secondaryOutcomes measure: Motor symptom severity, secondaryOutcomes measure: Demographics, eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 60 Years, stdAges: ADULT, contactsLocationsModule locations facility: Swiss Paraplegic Research, status: RECRUITING, city: Nottwil, state: Lucerne, zip: 6207, country: Switzerland, contacts name: Jothini Sritharan, MSc, role: CONTACT, phone: +41419396557, email: jothini.sritharan@paraplegie.ch, contacts name: Jothini Sritharan, MSc, role: SUB_INVESTIGATOR, geoPoint lat: 47.13472, lon: 8.13772, hasResults: False
protocolSection identificationModule nctId: NCT06309875, orgStudyIdInfo id: ENF- 25-2018, briefTitle: Effect of the PLAN CUIDARTE on the Caregiving Competence of People With Heart Failure, acronym: PLANCUIDARTE, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-25, primaryCompletionDateStruct date: 2024-06-25, completionDateStruct date: 2024-11-12, studyFirstPostDateStruct date: 2024-03-13, lastUpdatePostDateStruct date: 2024-03-13, sponsorCollaboratorsModule leadSponsor name: Universidad de la Sabana, class: OTHER, collaborators name: Universidad de Caldas, descriptionModule briefSummary: According to the World Health Organization (WHO), by 2021 cardiovascular diseases (CVD) will be a public health problem, among them heart failure (HF), since this is a chronic disease, patients should be competent in their care. Despite the above, according to research conducted in Colombia, 59.7% of people with chronic noncommunicable diseases (NCDs) have a level of care competence considered not optimal; patients report not having sufficient knowledge of the disease or experience feelings of lack of tools for the management of symptoms and the challenges of post-hospitalization.The objective of the research is to determine the effect of the PLAN CUIDARTE on the caregiving competence of people with HFMethodology: Pre-posttest randomized clinical trial, with blinding of the participants, where the intervention "PLAN CUIDARTE" is applied and the initial and subsequent caregiving competence is evaluated in the comparison group and in the intervention group for pretest - posttest and between-group comparisons., conditionsModule conditions: Heart Failure, conditions: Caregiver Burden, conditions: Discharge Plan, conditions: Care Transitions, conditions: Nursing, designModule studyType: INTERVENTIONAL, phases: PHASE2, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: A pre-post test Randomized Clinical Trial (RCT) is proposed with a comparison group, with blinding of the participants with blinding of the participants, with application of a pilot test beforehand. pilot test.The intervention group is established as the group that receives the PLAN CUIDARTE (intervention described later) and as a comparison group the one receiving the conventional discharge plan (described later), primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, whoMasked: PARTICIPANT, enrollmentInfo count: 84, type: ESTIMATED, armsInterventionsModule interventions name: PLAN CUIDARTE, interventions name: Conventional care, outcomesModule primaryOutcomes measure: Care Competence, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Universidad de Caldas, city: Manizales, state: Caldas, zip: 170004., country: Colombia, contacts name: Claudia Marcela Vallejo, Mag, role: CONTACT, phone: +573163614224, email: marcela.vallejo@ucaldas.edu.co, geoPoint lat: 5.06889, lon: -75.51738, hasResults: False
protocolSection identificationModule nctId: NCT06309862, orgStudyIdInfo id: 5993, briefTitle: Immune Checkpoint Inhibitor Therapy for Cancer and Risk of Myocarditis or Cardiomyopathy, statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-03-20, primaryCompletionDateStruct date: 2025-09-30, completionDateStruct date: 2025-12-31, studyFirstPostDateStruct date: 2024-03-13, lastUpdatePostDateStruct date: 2024-03-13, sponsorCollaboratorsModule leadSponsor name: Sunnybrook Health Sciences Centre, class: OTHER, descriptionModule briefSummary: Patients undergoing dual treatment with Immune checkpoint inhibitors (ICI) for various cancers, e.g. melanoma, are at increased risk of developing myocarditis and cardiomyopathy. Currently, only limited data on serial myocardial tissue changes during treatment and whether they predict outcomes are available. Cardiac MRI (CMR) is the reference standard for non-invasive myocardial volumes/function analysis and uniquely characterizes myocardial tissue. Therefore, it may help detect myocardial tissue changes during treatment and help early treatment and prevent adverse cardiac outcomes., conditionsModule conditions: Cardio-Oncology, conditions: Cardiomyopathy Due to Drug, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: PROSPECTIVE, enrollmentInfo count: 15, type: ESTIMATED, armsInterventionsModule, outcomesModule primaryOutcomes measure: Define changes in CMR tissue and blood biomarkers during ICI treatment., primaryOutcomes measure: Investigate associations between CMR imaging biomarkers and CMR-defined left ventricular ejection fraction., primaryOutcomes measure: Investigate associations between serum biomarkers and CMR-defined left ventricular ejection fraction., eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule, hasResults: False
protocolSection identificationModule nctId: NCT06309849, orgStudyIdInfo id: Jerash University, briefTitle: Efficacy of Physical Therapy Intervention in Cervical Angina Patients at Jerash University Office Employees, "Randomized Clinical Trail"., statusModule overallStatus: NOT_YET_RECRUITING, startDateStruct date: 2024-04-20, primaryCompletionDateStruct date: 2024-05-20, completionDateStruct date: 2024-06-01, studyFirstPostDateStruct date: 2024-03-13, lastUpdatePostDateStruct date: 2024-04-08, sponsorCollaboratorsModule leadSponsor name: South Valley University, class: OTHER, descriptionModule briefSummary: Cervicogenic angina (CA) is defined as paroxysmal angina- like pain that originates from the disorders of the cervical spine or other neck structures. Because CA mimics typical cardiac angina, symptoms in the elderly with cervical spondylosis are more frequently misdiagnosed Nakajima H, 2006. Patients with CA may have suffered symptoms for longer periods of time and seen several clinicians due to conflicting cardiac exams. Clinicians and patients are unaware that CA symptoms are stemming from cervical spine disorders. However, the mechanism of pain occurrence in patients with CA remains unclear., conditionsModule conditions: Cervical Radiculopathy, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: Randomized Control Trail (RCT) will be used in the study. Participants will be dived into experimental group and control group. Each group will includes 30 participants., primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: includes 30 participants., whoMasked: PARTICIPANT, enrollmentInfo count: 30, type: ESTIMATED, armsInterventionsModule interventions name: Manual physiotherapy intervention( cervical traction, suboccipital release, muscle energy technique), outcomesModule primaryOutcomes measure: 1-Hart Rate (HR) (bpm) using Electro Cardiac Graphic (ECG). 2- Blood pressure (mm Hg) using Sphygmomanometer., secondaryOutcomes measure: 3- Range of Motion (ROM) (in degrees) of the cervical spine using Electro-Goniometer. 4- the pain using Visual Analogue Scale (VAS) from (0-10), eligibilityModule sex: ALL, minimumAge: 20 Years, maximumAge: 60 Years, stdAges: ADULT, hasResults: False
protocolSection identificationModule nctId: NCT06309836, orgStudyIdInfo id: SID03, briefTitle: Retrospective and Prospective Observational Study in Patients With Advanced Basal Cell Carcinoma, acronym: REGISTRO-BCC, statusModule overallStatus: RECRUITING, startDateStruct date: 2021-06-23, primaryCompletionDateStruct date: 2024-06-23, completionDateStruct date: 2024-06-23, studyFirstPostDateStruct date: 2024-03-13, lastUpdatePostDateStruct date: 2024-03-13, sponsorCollaboratorsModule leadSponsor name: Societa Italiana di Dermatologia Medica, Chirurgica, Estetica e di Malattie Sessualmente Trasmesse, class: OTHER, descriptionModule briefSummary: Retrospective and Prospective Observational Study in Patients With Advanced Basal Cell Carcinoma., conditionsModule conditions: Basal Cell Carcinoma, designModule studyType: OBSERVATIONAL, designInfo observationalModel: COHORT, timePerspective: OTHER, enrollmentInfo count: 250, type: ESTIMATED, outcomesModule primaryOutcomes measure: clinical evolution, treatment and prognosis, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Irccs Fondazione Policlinico Gemelli, status: RECRUITING, city: Roma, state: ITA, zip: 00168, country: Italy, contacts name: peris MD Peris, role: CONTACT, phone: 0630154211, email: ketty.peris@unicatt.it, geoPoint lat: 41.89193, lon: 12.51133, hasResults: False
protocolSection identificationModule nctId: NCT06309823, orgStudyIdInfo id: 1000080330, briefTitle: A Single-patient Clinical Trial of MAS825 in a Patient With XIAP Deficiency, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-02-08, primaryCompletionDateStruct date: 2024-01-17, completionDateStruct date: 2024-01-17, studyFirstPostDateStruct date: 2024-03-13, lastUpdatePostDateStruct date: 2024-03-13, sponsorCollaboratorsModule leadSponsor name: The Hospital for Sick Children, class: OTHER, descriptionModule briefSummary: MAS825 is a bi-specific IgG1 monoclonal antibody that simultaneously targets IL-1 beta and IL-18, thereby neutralizing both cytokines that are thought to be integral to the pathogenesis of XLP-2. Clinical trials are currently examining its efficacy in other diseases associated with elevations of these cytokines, including NLRC4-associated disease and hidradenitis suppurativa. This study proposes to assess the effectiveness of MAS825 in a single patient with XLP-2, who has previously demonstrated response to blockade of IL-1 beta and IL-18. Given the lack of alternative pharmaceutical options for XLP-2, this represents the only known medication option that avoids the toxicity associated with high-dose corticosteroids and the morbidity associated with hematopoietic stem cell transplantation., conditionsModule conditions: X-linked Lymphoproliferative Syndrome Type 2 (XLP-2), designModule studyType: INTERVENTIONAL, phases: PHASE3, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 1, type: ACTUAL, armsInterventionsModule interventions name: MAS825, outcomesModule primaryOutcomes measure: Impact of MAS825 on Physician Global Assessment Score, primaryOutcomes measure: Impact of MAS825 on Physician Severity Assessment of Disease Signs and Symptoms, primaryOutcomes measure: Patient/Parent Global Assessment of Disease Activity, eligibilityModule sex: MALE, minimumAge: 13 Years, maximumAge: 14 Years, stdAges: CHILD, contactsLocationsModule locations facility: The Hospital for Sick Children, city: Toronto, state: Ontario, zip: M5G1X8, country: Canada, geoPoint lat: 43.70011, lon: -79.4163, hasResults: False
protocolSection identificationModule nctId: NCT06309810, orgStudyIdInfo id: 2022-35, briefTitle: Stereotactic Radiosurgery (SRS) in Malignant Spasticity and Hypertonia, statusModule overallStatus: RECRUITING, startDateStruct date: 2023-03-06, primaryCompletionDateStruct date: 2025-08, completionDateStruct date: 2025-08, studyFirstPostDateStruct date: 2024-03-13, lastUpdatePostDateStruct date: 2024-03-13, sponsorCollaboratorsModule leadSponsor name: IRCCS Sacro Cuore Don Calabria di Negrar, class: OTHER, descriptionModule briefSummary: This is a pilot, experimental, monocentric study. The main objective of the study is to evaluate whether stereotactic radiotherapy is able to reduce symptomatic spasticity from a clinical point of view, and therefore induce an improvement in posture and quality of life in patients with malignant spasticity.The study foresees the enrollment of about 10 patients, in a period of 24 months. The radiotherapy treatment will be delivered in a single session with an image-guided stereotaxic technique, and a prescription dose between 45 and 60 Gy; subsequently the patients will be followed up for one year., conditionsModule conditions: Spasticity/Paresis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: NA, interventionModel: SINGLE_GROUP, primaryPurpose: TREATMENT, maskingInfo masking: NONE, enrollmentInfo count: 10, type: ESTIMATED, armsInterventionsModule interventions name: Radiotherapy, outcomesModule primaryOutcomes measure: MAS, secondaryOutcomes measure: Acute and late toxicity (CTCAE), secondaryOutcomes measure: Quality of life (SF-12), secondaryOutcomes measure: Quality of nursing (VAS), secondaryOutcomes measure: Radiological characteristics and treatment-related changes of the spinal roots, eligibilityModule sex: ALL, minimumAge: 18 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: IRCCS Sacro Cuore Don Calabria di Negrar, status: RECRUITING, city: Negrar, state: Verona, zip: 37024, country: Italy, contacts name: Luca Nicosia, Doctor, role: CONTACT, phone: +39(0)456014800, email: luca.nicosia@sacrocuore.it, geoPoint lat: 45.52918, lon: 10.93899, hasResults: False
protocolSection identificationModule nctId: NCT06309797, orgStudyIdInfo id: OSATAGUN2, briefTitle: Effects of Interdental Brush Dipped in 0.2% Hyaluronic Acid Gel on Periodontitis, statusModule overallStatus: COMPLETED, startDateStruct date: 2023-05-02, primaryCompletionDateStruct date: 2024-01-26, completionDateStruct date: 2024-02-05, studyFirstPostDateStruct date: 2024-03-13, lastUpdatePostDateStruct date: 2024-03-13, sponsorCollaboratorsModule leadSponsor name: Özlem SARAÇ ATAGÜN, class: OTHER, descriptionModule briefSummary: This study aimed to compare the effects of using an interdental brush dipped in 0.2% HA gel with those of using a regular interdental brush on clinical periodontal parameters following SRP among patients with periodontitis., conditionsModule conditions: Periodontitis, designModule studyType: INTERVENTIONAL, phases: NA, designInfo allocation: RANDOMIZED, interventionModel: PARALLEL, interventionModelDescription: single-center, single-blinded, randomized controlled trial, primaryPurpose: TREATMENT, maskingInfo masking: SINGLE, maskingDescription: The investigator carrying out the measurements was not aware of which patients were assigned to the test group., whoMasked: INVESTIGATOR, enrollmentInfo count: 60, type: ACTUAL, armsInterventionsModule interventions name: Interdental brush+HA, interventions name: Interdental brush, outcomesModule primaryOutcomes measure: Gingival index (GI), primaryOutcomes measure: Plaque index (PI), primaryOutcomes measure: Papillary bleeding index (PBI), primaryOutcomes measure: Pocket depth (PD), primaryOutcomes measure: Clinical attachment loss (CAL), eligibilityModule sex: ALL, minimumAge: 18 Years, maximumAge: 65 Years, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Sağlık Bilimleri Üniversitesi Gülhane Diş Hekimliği Fakültesi, city: Ankara, zip: 06010, country: Turkey, geoPoint lat: 39.91987, lon: 32.85427, hasResults: False