protocolSection identificationModule nctId: NCT06379230, orgStudyIdInfo id: SH9H-2023-T378-1, briefTitle: A Retrospective Study on Epidemiological Characteristics of Chinese NF1 Patients in Real World (PROMISE), statusModule overallStatus: RECRUITING, startDateStruct date: 2019-01-01, primaryCompletionDateStruct date: 2022-12-31, completionDateStruct date: 2025-02-28, studyFirstPostDateStruct date: 2024-04-23, lastUpdatePostDateStruct date: 2024-04-23, sponsorCollaboratorsModule leadSponsor name: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, class: OTHER, descriptionModule briefSummary: Background/Rationale: Neurofibromatosis type 1 (NF1) affects about 1 in every 3000 people worldwide. Globally, 30\~50% NF1 patients will develop plexiform neurofibromas (PNs), which grow rapidly in early childhood and can cause disfigurement, motor dysfunction, pain, airway dysfunction, visual impairment and bladder and bowel dysfunction. This systemic disease imposes a heavy psychosomatic and financial burden on patients and their caregivers. In NF1 patients, the lifetime risk of MPNST developed from PN is 8% to 13%. The mean age for NF1-associated death was approximately 20 years lower than that for the general population. Limited epidemiological and clinical data of Chinese NF1 patients is available to date. And the treatment pattern of Chinese NF1-PN patients is also unknown.Objectives and Hypotheses: It is a descriptive study without formal hypothesis. The primary objective of this study is determining the percentage of NF1 patients who develop PN. The secondary objectives of this study include describing the clinical characteristics, tumor progression and treatment pattern of NF1-PN. The exploratory objective is exploring the epidemiological characteristics of other NF1 manifestations.Methods:Study design: The study is a retrospective multi-center chart review study. Data Source(s): All the data will be collected by CRF from inpatient and outpatient electronic medical records in every study site from January 1, 2019 to December 31, 2022.Study Population: Patients who attended the study sites between January 1, 2019 - December 31, 2022 and were diagnosed with NF1 were included in this study. Statistical Analysis: This study is purely descriptive without any formal hypotheses.Missing data for baseline characteristics will be assessed and addressed as a categorical variable with a level for missingness. All reported measures will be summarized in the study tables. Point estimates and their 95% CIs will be presented in the final analyses., conditionsModule conditions: Neurofibromatosis 1, conditions: Plexiform Neurofibroma, designModule studyType: OBSERVATIONAL, designInfo observationalModel: OTHER, timePerspective: RETROSPECTIVE, enrollmentInfo count: 2000, type: ESTIMATED, armsInterventionsModule interventions name: This study is purely descriptive study., outcomesModule primaryOutcomes measure: Determine the percentage of NF1 patients developed PN at the baseline., secondaryOutcomes measure: Clinical characteristics of NF1-PN:, secondaryOutcomes measure: Tumor progression of NF1-PN, secondaryOutcomes measure: Treatment pattern of NF1-PN:, otherOutcomes measure: The exploratory endpoints:, eligibilityModule sex: ALL, stdAges: CHILD, stdAges: ADULT, stdAges: OLDER_ADULT, contactsLocationsModule locations facility: Xuanwu Hospital, Capital Medical University, status: RECRUITING, city: Beijing, state: Beijing, country: China, contacts name: Lei Zhang, role: CONTACT, phone: +86 13683139858, email: zhanglei@xwhosp.org, geoPoint lat: 39.9075, lon: 116.39723, locations facility: The First Affiliated Hospital of Guangxi Medical University, status: RECRUITING, city: Nanning, state: Guangxi, country: China, contacts name: Jiping Shi, role: CONTACT, phone: +86 17758670856, geoPoint lat: 22.81667, lon: 108.31667, locations facility: The First Affiliated Hospital of Zhengzhou University, status: RECRUITING, city: Zhengzhou, state: Henan, country: China, contacts name: Minjing Chen, role: CONTACT, phone: +86 13673665337, email: 1916833431@qq.com, geoPoint lat: 34.75778, lon: 113.64861, locations facility: Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, status: ACTIVE_NOT_RECRUITING, city: Shanghai, state: Shanghai, zip: 200011, country: China, geoPoint lat: 31.22222, lon: 121.45806, locations facility: West China Hospital, Sichuan University, status: RECRUITING, city: Chengdu, state: Sichuan, country: China, contacts name: Yang Xiao, role: CONTACT, phone: +86 18884266797, email: xiaoyang_angela@163.com, geoPoint lat: 30.66667, lon: 104.06667, hasResults: False